{"id":246059,"date":"2023-01-25T06:00:56","date_gmt":"2023-01-24T22:00:56","guid":{"rendered":"\/\/m.iemloyee.com\/?p=246059"},"modified":"2023-01-25T23:12:31","modified_gmt":"2023-01-25T15:12:31","slug":"%e3%80%90%e5%b7%b2%e5%ae%a1%e3%80%91%e5%8d%a1%e5%86%85%e5%9f%ba%e6%a2%85%e9%9a%86%e5%a4%a7%e5%ad%a6nat-biotechnol%ef%bc%9a%e4%b8%80%e7%a7%8d%e7%94%a8%e4%ba%8e%e6%89%a9%e5%bc%a0%e6%98%be%e5%be%ae","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=246059","title":{"rendered":"\u5361\u5185\u57fa\u6885\u9686\u5927\u5b66Nat Biotechnol\uff1a\u4e00\u79cd\u7528\u4e8e\u6269\u5f20\u663e\u5fae\u672f\u7684\u901a\u7528\u5206\u5b50\u951a\u5b9a\u7b56\u7565"},"content":{"rendered":"<p style=\"text-align: center;\">\u4e00\u3001\u3010\u5bfc\u8bfb\u3011<\/p>\n<p>\u5bf9\u751f\u7269\u7cfb\u7edf\u7684\u5168\u9762\u7406\u89e3\u9700\u8981\u7cbe\u786e\u5730\u4e86\u89e3\u4ece\u7ec4\u7ec7\u6c34\u5e73\u5230\u5355\u4e2a\u751f\u7269\u5206\u5b50\u957f\u5ea6\u5c3a\u5ea6\u4e0a\u7ec4\u5206\u7684\u7a7a\u95f4\u6392\u5217\u3002\u800c\u6269\u5f20\u663e\u5fae\u672f(ExM)\u662f\u4e00\u79cd\u4ec5\u4f7f\u7528\u884d\u5c04\u6781\u9650\u8367\u5149\u663e\u5fae\u955c\u5c31\u80fd\u5b9e\u73b0\u7684\u7eb3\u7c73\u7ea7\u6210\u50cf\u7684\u6280\u672f\u3002ExM\u4ee5\u7269\u7406\u548c\u5404\u5411\u540c\u6027\u7684\u65b9\u5f0f\u653e\u5927\u7ec6\u80de\u548c\u7ec4\u7ec7:\u751f\u7269\u5206\u5b50\u5171\u4ef7\u8fde\u63a5\u5230\u81f4\u5bc6\u548c\u53ef\u6eb6\u80c0\u7684\u805a\u7535\u89e3\u8d28\u6c34\u51dd\u80f6\u4e0a\uff0c\u5e76\u5728\u5316\u5b66\u5904\u7406\u540e\u5728\u6c34\u4e2d\u5f7c\u6b64\u8fdc\u79bb\u3002\u6269\u5f20\u663e\u5fae\u955c\u901a\u8fc7\u7269\u7406\u548c\u5404\u5411\u540c\u6027\u653e\u5927\u5d4c\u5165\u9047\u6c34\u81a8\u80c0\u7684\u6c34\u51dd\u80f6\u4e2d\u7684\u4fdd\u5b58\u7684\u751f\u7269\u6807\u672c\uff0c\u4f7f\u4f20\u7edf\u663e\u5fae\u955c\u7684\u7eb3\u7c73\u6210\u50cf\u6210\u4e3a\u53ef\u80fd\u3002\u76ee\u524d\u7684\u81a8\u80c0\u663e\u5fae\u955c\u65b9\u6848\u9700\u8981\u9884\u5148\u7528\u53cd\u5e94\u6027\u951a\u5b9a\u5316\u5b66\u7269\u8d28\u8fdb\u884c\u5904\u7406\uff0c\u4ee5\u5c06\u7279\u5b9a\u7684\u6807\u8bb0\u548c\u751f\u7269\u5206\u5b50\u7c7b\u522b\u8fde\u63a5\u5230\u51dd\u80f6\u4e0a\u3002\u7b80\u5316\u8fd9\u4e00\u6b65\u9aa4\uff0c\u5c06\u4f7f\u5f97\u6269\u5f20\u663e\u5fae\u955c\u7684\u5e94\u7528\u66f4\u52a0\u5e7f\u6cdb\u3002<\/p>\n<p style=\"text-align: center;\">\u4e8c\u3001\u3010\u6210\u679c\u63a0\u5f71\u3011<\/p>\n<p>\u5361\u5185\u57fa\u6885\u9686\u5927\u5b66Yongxin Zhao\u6559\u6388\u63cf\u8ff0\u4e86\u4e00\u79cd\u540d\u4e3aMagnify\u7684\u7b56\u7565\uff0c\u8be5\u7b56\u7565\u4f7f\u7528\u673a\u68b0\u575a\u56fa\u7684\u51dd\u80f6\u6765\u4fdd\u7559\u6838\u9178\u3001\u86cb\u767d\u8d28\u548c\u8102\u8d28\uff0c\u800c\u4e0d\u9700\u8981\u5355\u72ec\u7684\u951a\u5b9a\u6b65\u9aa4\u3002Magnify\u53ef\u5c06\u751f\u7269\u6807\u672c\u653e\u592711\u500d\uff0c\u5e76\u80fd\u591f\u4f7f\u5e38\u89c4\u5149\u5b66\u663e\u5fae\u955c\u4e0a\u4ee5\u7ea6280 nm\u884d\u5c04\u6781\u9650\u7684\u7269\u955c\u548c\u6709\u6548\u5206\u8fa8\u7387\u7ea6\u4e3a25 nm\u7684\u6761\u4ef6\u4e0b\u5bf9\u7ec6\u80de\u548c\u7ec4\u7ec7\u8fdb\u884c\u6210\u50cf\uff0c\u5982\u679c\u7ed3\u5408\u8d85\u5206\u8fa8\u7387\u5149\u5b66\u6ce2\u52a8\u6210\u50cf\uff0c\u5219\u6709\u6548\u5206\u8fa8\u7387\u7ea6\u4e3a15 nm\u3002\u5e76\u4e14\u5728\u5e7f\u6cdb\u7684\u751f\u7269\u6807\u672c\u4e0a\u6f14\u793a\u4e86Magnify\uff0c\u63d0\u4f9b\u4e86\u5bf9\u7eb3\u7c73\u7ea7\u4e9a\u7ec6\u80de\u7ed3\u6784\u7684\u6df1\u5165\u4e86\u89e3\uff0c\u6bd4\u5982\u6765\u81ea\u5c0f\u9f20\u5927\u8111\u7684\u7a81\u89e6\u86cb\u767d\uff0c\u798f\u5c14\u9a6c\u6797\u56fa\u5b9a\u77f3\u8721\u5305\u57cb\u7684\u4eba\u7c7b\u80be\u810f\u4e2d\u7684\u8db3\u7ec6\u80de\u8db3\u7a81\uff0c\u4ee5\u53ca\u836f\u7269\u5904\u7406\u7684\u4eba\u7c7b\u80ba\u7c7b\u5668\u5b98\u4e2d\u7684\u7ea4\u6bdb\u548c\u57fa\u5e95\u4f53\u7f3a\u9677\u3002\u76f8\u5173\u6210\u679c\u4ee5\u201c<strong>Magnify is a universal molecular anchoring strategy for expansion microscopy<\/strong>\u201d\u53d1\u8868\u5728<strong><em>Nature biotechnology<\/em><\/strong>\u4e0a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-246060\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72471-21.png\" alt=\"\" width=\"554\" height=\"187\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72471-21.png 554w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72471-21-300x101.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u4e09\u3001\u3010<\/strong>\u6838\u5fc3\u521b\u65b0\u70b9<strong>\u3011<\/strong><\/p>\n<p>\u91c7\u7528\u4e00\u79cd\u540d\u4e3aMagnify\u7684\u7b56\u7565\uff0cMagnify\u4f7f\u7528\u6c34\u51dd\u80f6\u914d\u65b9\uff0c\u4fdd\u7559\u4e86\u751f\u7269\u5206\u5b50\u7684\u5149\u8c31\uff0c\u4ece\u800c\u6d88\u9664\u4e86\u5355\u72ec\u7684\u5206\u5b50\u7279\u5f02\u6027\u951a\u5b9a\u6b65\u9aa4\u7684\u9700\u8981\u3002<\/p>\n<p style=\"text-align: center;\">\u56db\u3001\u3010\u6570\u636e\u6982\u89c8\u3011<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-246061\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72472-19.png\" alt=\"\" width=\"1269\" height=\"1724\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72472-19.png 1269w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72472-19-221x300.png 221w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72472-19-768x1043.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72472-19-754x1024.png 754w\" sizes=\"(max-width: 1269px) 100vw, 1269px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>1 <\/strong>\u00a0Magnify\u534f\u8bae\u7684\u8bbe\u8ba1\u548c\u9a8c\u8bc1\u3002\u00a92023 The author(s)<\/p>\n<p>a\uff0cMagnify\u65b9\u6848\u3002b\uff0cMagnify\u51dd\u80f6\u5316\u5b66\u3002c, Magnify\u5c55\u5f00\u7684\u5c0f\u9f20\u8111\u5207\u7247\u3002d\uff0c\u86cb\u767d\u8d28\u6c34\u89e3\u6d88\u5316\u540e\u8367\u5149\u4fe1\u53f7\u88ab\u4fdd\u7559\u3002e\uff0c\u5728\u4e0d\u540c\u951a\u5b9a\u548c\u5747\u8d28\u5316\u7b56\u7565\u4e0b\uff0cFFPE\u4eba\u7c7b\u80be\u810f\u5207\u7247(\u84dd\u8272)\u548cPFA\u56fa\u5b9a\u5c0f\u9f20\u5927\u8111\u5207\u7247(\u7eff\u8272)\u4e2d\u86cb\u767d\u8d28\u4fdd\u7559\u7684\u6bd4\u8f83\u3002f\uff0c\u5728Magnify\u6846\u67b6\u4e0b\uff0c\u4e0d\u540c\u7ec4\u7ec7\u7c7b\u578b\u7684\u86cb\u767d\u8d28\u4fdd\u7559\u6bd4\u8f83\u3002g\uff0cMagnify\u540e\u514d\u75ab\u67d3\u8272\u3002h, Magnify\u53ef\u4ee5\u5b9e\u73b0\u7eb3\u7c73\u7ea7\u7a81\u89e6\u7ed3\u6784\u7684\u53ef\u89c6\u5316\u3002i\uff0c\u7528Magnify\u6d4b\u91cf\u5c0f\u9f20\u5927\u8111\u4e2dhomer-bassoon\u7a81\u89e6\u5bf9\u7684\u8ddd\u79bb\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-246062\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72473-21.png\" alt=\"\" width=\"1269\" height=\"1632\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72473-21.png 1269w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72473-21-233x300.png 233w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72473-21-768x988.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72473-21-796x1024.png 796w\" sizes=\"(max-width: 1269px) 100vw, 1269px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>2<\/strong> Magnify\u5728\u51e0\u79cd\u7ec4\u7ec7\u7c7b\u578b\u4e2d\u7684\u9a8c\u8bc1\u3002\u00a92023 The author(s)<\/p>\n<p>a,b\uff0c\u5728\u00d760\u6210\u50cf\u5e76\u4f7f\u7528SOFI\u5904\u7406\u7684\u4eba\u7c7b\u80be\u810f\u6269\u5f20\u524d\u56fe\u50cf\u793a\u4f8b(a)\u4e0e\u5728\u00d740\u4f7f\u7528Magnify\u62cd\u6444\u7684\u76f8\u540cFOV\u6269\u5f20\u540e\u56fe\u50cf(b)\u8fdb\u884c\u6bd4\u8f83\u3002c -e, RMS\u957f\u5ea6\u6d4b\u91cf\u8bef\u5dee\u4f5c\u4e3aDAPI (c)\uff0c ACTN4 (d)\u548cVimentin (e)\u5c55\u5f00\u524d\u4e0e\u5c55\u5f00\u540e\u56fe\u50cf\u6d4b\u91cf\u957f\u5ea6\u7684\u51fd\u6570\u3002f,g\uff0c\u5982a\u548cb\u6240\u793a\u7684\u4eba\u7c7b\u524d\u5217\u817a\u56fe\u50cf\u793a\u4f8b\u3002h,i, RMS\u957f\u5ea6\u6d4b\u91cf\u8bef\u5dee\u4f5c\u4e3aDAPI (h)\u548cATPIF (i)\u5c55\u5f00\u524d\u548c\u5c55\u5f00\u540e\u56fe\u50cf\u6d4b\u91cf\u957f\u5ea6\u7684\u51fd\u6570\u3002j-o\uff0c\u5728\u51e0\u79cd\u4eba\u4f53\u7ec4\u7ec7\u7c7b\u578b\u4e2d\u9a8c\u8bc1Magnify\u3002p-r\uff0c\u4eba\u4f53\u7ec4\u7ec7\u76843D\u56fe\u50cf\u793a\u4f8b.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-246063\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72474-20.png\" alt=\"\" width=\"1269\" height=\"1496\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72474-20.png 1269w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72474-20-254x300.png 254w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72474-20-768x905.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72474-20-869x1024.png 869w\" sizes=\"(max-width: 1269px) 100vw, 1269px\" \/><\/p>\n<p><strong>\u56fe3<\/strong> \u7528Magnify\u6210\u50cf\u751f\u7269\u6807\u672c\u4e2d\u7684\u86cb\u767d\u8d28\u3001\u6838\u9178\u548c\u8102\u8d28\u3002\u00a92023 The author(s)<\/p>\n<p>a\uff0c\u865a\u7ebf\u67f1\u72b6\u56fe\u663e\u793a\u70ed\u53d8\u6027\u7f13\u51b2\u6db2\u4e2d\u8102\u8d28\u4fdd\u7559\u7387\u968f\u5747\u5300\u5316\u65f6\u95f4\u7684\u53d8\u5316\u3002b\uff0c\u8102\u8d28\u5728\u5b8c\u5168\u5c55\u5f00\u7684Magnify\u5904\u7406\u5c0f\u9f20\u5927\u8111\u7684\u53ef\u89c6\u5316\u3002c\uff0c\u7528\u4eb2\u8102\u6027\u67d3\u6599DiD\u5728Magnify\u5904\u7406\u7684\u5c0f\u9f20\u5927\u8111\u4e2d\u663e\u793a\u7ebf\u7c92\u4f53\u3002d, Magnify\u6269\u589eHEK-293FT\u7ec6\u80de\u9ad8\u5c14\u57fa\u819c\u7684\u4eb2\u8102\u6027\u67d3\u8272\u3002e, HEK-293FT\u7ec6\u80de\u7684Magnify\u56fe\u50cf\u4e0ed\u76f8\u4f3c\uff0c\u4f46\u663e\u793aDiD\u6838\u819c\u6807\u8bb0\u3002f, Magnify\u6269\u5f20\u5c0f\u9f20\u8111\u8840\u7ba1\u7684\u4eb2\u8102\u6027\u67d3\u8272\u3002g\uff0c\u4eba\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u80ba\u7c7b\u5668\u5b98\u4e2d\u7ec6\u80de\u5916\u56ca\u6ce1\u7684\u7535\u5b50\u663e\u5fae\u7167\u7247\u3002h\uff0c\u5b8c\u5168\u6269\u5f20\u7684\u4eba\u80ba\u7c7b\u5668\u5b98\u80de\u5916\u56ca\u6ce1\u7684\u53cc\u8272Magnify\u56fe\u50cf\u3002j\uff0c\u653e\u5927g\u4e2d\u88ab\u6846\u4f4f\u7684\u533a\u57df\u3002k, h\u5185\u6240\u9009\u7ec6\u80de\u5916\u56ca\u6ce1\u7684\u4e09\u7ef4\u91cd\u5efa\uff0c\u5982\u84dd\u8272\u865a\u7ebf\u6846\u6240\u793a\u3002l, k\u4e2d\u7ec6\u80de\u5916\u56ca\u6ce1\u7684\u6b63\u4ea4\u56fe\u3002m\uff0c\u4eba\u7c7b\u6dcb\u5df4\u7ed3\u7ec4\u7ec7\u5171\u805a\u7126\u56fe\u50cf\u76843D\u91cd\u5efa\u3002n\uff0c\u6269\u5c55HEK-293FT\u7ec6\u80de\u5171\u805a\u7126\u56fe\u50cf\u7684\u4e09\u7ef4\u91cd\u5efa\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-246064\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72475-19.png\" alt=\"\" width=\"1269\" height=\"1375\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72475-19.png 1269w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72475-19-277x300.png 277w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72475-19-768x832.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72475-19-945x1024.png 945w\" sizes=\"(max-width: 1269px) 100vw, 1269px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>4 <\/strong>\u4f7f\u7528Magnify\u663e\u793a\u5185\u6e90\u6027\u8367\u5149\u56e2\u3002\u00a92023 The author(s)<\/p>\n<p>a\uff0c\u7528Magnify-ProK\u6269\u5c55\u7684\u5c0f\u9f20\u5927\u8111\u77e2\u72b6\u5207\u7247\u7684\u6700\u5927\u5f3a\u5ea6\u6295\u5f71\u3002b\uff0c\u5728a\u4e2d\u653e\u5927\u663e\u793a\u6210\u50cf\u573a\u4e2d\u7684\u6846\u5185\u533a\u57df\u3002c\uff0c\u653e\u5927b\u4e2d\u88ab\u6846\u4f4f\u7684\u533a\u57df\u3002d, c\u5408\u5e76\u56fe\u5c42\u7684\u4e09\u7ef4\u91cd\u5efa\u3002e\uff0c\u5728\u5b8c\u5168\u6269\u5f20\u7684\u5c0f\u9f20\u76ae\u5c42\u4e2d\u4e09\u7ef4\u91cd\u5efaSST\u7ec6\u80de\uff0c\u7528Magnify\u8fdb\u884c\u6269\u5f20\uff0c\u7528\u70ed\u8868\u9762\u6d3b\u6027\u5242\u6eb6\u6db2\u5747\u8d28\u3002f\uff0c\u653e\u5927e\u4e2d\u6846\u72b6\u533a\u57df\uff0c\u663e\u793a\u6811\u7a81\u68d8\u4e0a\u7684\u7a81\u89e6\u3002g\uff0c\u4e0ee\u76f8\u540c\u6837\u672c\u7684\u5c0f\u9f20\u76ae\u5c42\u5b8c\u5168\u6269\u5f20\u7684SST\u795e\u7ecf\u5143\u7684\u5355z\u5e73\u9762\u3002h\uff0c\u653e\u5927e\u4e2d\u6846\u72b6\u533a\u57df\uff0c\u663e\u793a\u7a81\u89e6\u4f4d\u4e8eSST\u6811\u7a81\u4e0a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-246065\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72476-11.png\" alt=\"\" width=\"1269\" height=\"1077\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72476-11.png 1269w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72476-11-300x255.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72476-11-768x652.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72476-11-1024x869.png 1024w\" sizes=\"(max-width: 1269px) 100vw, 1269px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>5<\/strong> Magnify-SOFI\u663e\u793a\u4e86\u7ec6\u80de\u6210\u5206\u7684\u8d85\u5fae\u7ed3\u6784\u3002\u00a92023 The author(s)<\/p>\n<p>a, Magnify\u548cMagnify &#8211; SOFI\u7684\u6bd4\u8f83\u3002b\uff0c\u4eba\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u80ba\u7c7b\u5668\u5b98\u7ea4\u6bdb\u7684\u7535\u955c\u56fe\u3002c\uff0c\u4e0eb\u76f8\u540c\u7c7b\u578b\u7ec4\u7ec7\u7684\u7ea4\u6bdb\u5171\u805a\u7126\u56fe\u50cf\u3002d, c\u7ea4\u6bdb\u4e09\u7ef4\u91cd\u5efa\u3002e\uff0c\u4e0eb\u4e2d\u76f8\u540c\u7c7b\u5668\u5b98\u4e2d\u7ebf\u7c92\u4f53\u7684\u7535\u5b50\u663e\u5fae\u7167\u7247\u3002f\uff0c\u4e0ee\u4e2d\u76f8\u540c\u7684\u81a8\u5927\u7c7b\u5668\u5b98\u7684\u7ebf\u7c92\u4f53\u5171\u805a\u7126\u56fe\u50cf\u3002g, e\u4e2d\u7ea2\u6846\u6240\u793a\u7ebf\u7c92\u4f53\u7684\u6b63\u4ea4\u56fe\u3002h\uff0c\u6210\u5e74\u5c0f\u9f20\u8111\u5ba4\u7ba1\u819c\u7ec6\u80de\u886c\u91cc\u5ba4\u7ba1\u819c\u7ea4\u6bdb\u548c\u57fa\u5e95\u7684Magnify -SOFI\u56fe\u50cf\u5806\u6808\u7684\u6700\u5927\u5f3a\u5ea6\u6295\u5f71\u3002i, h\u7684\u4e09\u7ef4\u91cd\u5efa\u3002j,k\uff0c\u5c06i\u4e2d\u7ea2\u8272\u865a\u7ebf\u6846\u6240\u793a\u7684\u5355\u4e2a\u5ba4\u7ba1\u819c\u7ea4\u6bdb3D\u56fe\u50cf\u653e\u5927\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-246066\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72477-5.png\" alt=\"\" width=\"1269\" height=\"1314\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72477-5.png 1269w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72477-5-290x300.png 290w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72477-5-768x795.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/01\/\u56fe\u72477-5-989x1024.png 989w\" sizes=\"(max-width: 1269px) 100vw, 1269px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>6 <\/strong>Magnify -SOFI\u663e\u793a\u4e86\u7ec6\u5fae\u7684\u7eb3\u7c73\u7ea7\u836f\u7269\u8bf1\u5bfc\u53d8\u5316\u3002\u00a92023 The author(s)<\/p>\n<p>a\uff0c\u6b63\u5e38\u4eba\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u80ba\u7c7b\u5668\u5b98\u4e2d\u7ea4\u6bdb\u7684\u7535\u5b50\u663e\u5fae\u56fe\u3002b\uff0c\u4e0ea\u76f8\u4f3c\uff0c\u53ea\u662f\u80ba\u7c7b\u5668\u5b98\u7528\u7d2b\u6749\u9187\u6cbb\u7597\u3002c, Magnify -SOFI\u7ea4\u6bdb\u56fe\u50cf\uff0c\u4e0ea\u76f8\u540c\u7c7b\u578b\u7684\u7ec4\u7ec7\u3002d\uff0c\u4e0ec\u76f8\u4f3c\uff0c\u53ea\u662f\u80ba\u7c7b\u5668\u5b98\u7528\u7d2b\u6749\u9187\u6cbb\u7597\u3002e\uff0c\u5e26\u6709\u7a81\u51fa\u7ec6\u6839\u7684\u57fa\u90e8\u7684\u7535\u5b50\u663e\u5fae\u7167\u7247\u3002f\uff0c\u4e0ee\u540c\u7c7b\u578b\u7ec4\u7ec7\u5bf9\u5e94\u7684\u57fa\u5e95\u4f53\u5171\u7126\u56fe\u50cf\u3002g\uff0c\u643a\u5e26CCDC39\u7a81\u53d8\u7684\u4eba\u652f\u6c14\u7ba1\u57fa\u5e95\u5e72\u7ec6\u80de\u6765\u6e90\u80ba\u7c7b\u5668\u5b98\u7684\u4eba\u5e72\u7ec6\u80de\u6765\u6e90\u80ba\u7c7b\u5668\u5b98\u4e2d\u7ea4\u6bdb\u7684\u7535\u5b50\u663e\u5fae\u7167\u7247\u3002h\uff0c\u4e0eg\u76f8\u4f3c\u7ec4\u7ec7\u4e2d\u7ea4\u6bdb\u7684Magnify -SOFI\u56fe\u50cf\u3002i, Magnify -SOFI\u56fe\u50cf(\u4e0a)\u548c\u7535\u5b50\u663e\u5fae\u7167\u7247(\u4e0b)\u6709\u548c\u6ca1\u6709\u7f3a\u9677\u7ea4\u6bdb\u7684\u5e76\u6392\u6bd4\u8f83\u3002j\uff0c\u5728\u6b63\u5e38\u7684\u3001\u7d2b\u6749\u9187\u5904\u7406\u7684(PAX\u6837\u672c)\u548cCCDC39\u7a81\u53d8\u7684\u4eba\u652f\u6c14\u7ba1\u57fa\u5e95\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u80ba\u7c7b\u5668\u5b98(PCD\u6837\u672c)\u4e2d\u6b63\u5e38\u548c\u5f02\u5e38\u7ea4\u6bdb\u6bd4\u4f8b\u7684\u5806\u53e0\u67f1\u72b6\u56fe\u3002<\/p>\n<p style=\"text-align: center;\">\u4e94\u3001\u3010\u6210\u679c\u542f\u793a\u3011<\/p>\n<p>\u603b\u4e4b\uff0c\u7531\u4e8eMagnify\u662f\u4e00\u79cd\u4e0d\u4f9d\u8d56\u4e8e\u590d\u6742\u5149\u5b66\u7684\u5316\u5b66\u7b56\u7565\uff0c\u5b83\u63d0\u4f9b\u4e86\u4e00\u4e2a\u7075\u6d3b\u7684\u6846\u67b6\uff0c\u53ef\u4ee5\u9002\u5e94\u4e00\u7cfb\u5217\u6210\u50cf\u6a21\u5f0f\uff0c\u51dd\u80f6\u5316\u5b66\u548c\u5176\u4ed6ExM\u7b56\u7565\u3002Magnify\u8fd8\u53ef\u4ee5\u901a\u8fc7\u5176\u4ed6\u6a21\u5f0f\u5b9e\u73b0\u7eb3\u7c73\u7ea7\u6210\u50cf\uff0c\u4f8b\u5982\u53d7\u6fc0\u62c9\u66fc\u6563\u5c04\u548c\u5404\u79cd\u57fa\u4e8e\u8d28\u8c31\u7684\u6210\u50cf\u6280\u672f\u3002\u6700\u540e\uff0cMagnify\u53ef\u4ee5\u5728\u9ad8\u542b\u91cf\u6210\u50cf\u7cfb\u7edf\u4e2d\u5b9e\u73b0\uff0c\u5176\u4e2d\u53ef\u4ee5\u751f\u6210\u5927\u578b\u6570\u636e\u96c6\uff0c\u4ee5\u63a2\u7d22\u836f\u7269\u6cbb\u7597\u548c\u75be\u75c5\u76f8\u5173\u53d8\u5316\u5bf9\u57f9\u517b\u7ec6\u80de\u548c\u7ec4\u7ec7\u6a21\u578b\u4e2d\u751f\u7269\u5206\u5b50\u7eb3\u7c73\u7ea7\u914d\u7f6e\u7684\u5f71\u54cd\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u539f\u6587\u8be6\u60c5\uff1aKlimas, A., Gallagher, B.R., Wijesekara, P. et al. Magnify is a universal molecular anchoring strategy for expansion microscopy. <strong><em>Nat Biotechnol <\/em><\/strong>(2023).<\/p>\n<p>https:\/\/doi.org\/10.1038\/s41587-022-01546-1<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001\u3010\u5bfc\u8bfb\u3011 \u5bf9\u751f\u7269\u7cfb\u7edf\u7684\u5168\u9762\u7406\u89e3\u9700\u8981\u7cbe\u786e\u5730\u4e86\u89e3\u4ece\u7ec4\u7ec7\u6c34\u5e73\u5230\u5355\u4e2a\u751f\u7269\u5206\u5b50\u957f\u5ea6\u5c3a\u5ea6\u4e0a\u7ec4\u5206\u7684\u7a7a\u95f4\u6392\u5217\u3002\u800c\u6269\u5f20\u663e\u5fae\u672f(ExM)\u662f\u4e00\u79cd\u4ec5\u4f7f\u7528\u884d\u5c04\u6781\u9650\u8367\u5149\u663e\u5fae\u955c\u5c31\u80fd\u5b9e\u73b0\u7684&#8230;<\/p>\n","protected":false},"author":34544,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-246059","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/246059"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/34544"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=246059"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/246059\/revisions"}],"predecessor-version":[{"id":246298,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/246059\/revisions\/246298"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=246059"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=246059"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=246059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}