{"id":244663,"date":"2022-12-07T06:17:16","date_gmt":"2022-12-06T22:17:16","guid":{"rendered":"\/\/m.iemloyee.com\/?p=244663"},"modified":"2022-12-06T20:17:32","modified_gmt":"2022-12-06T12:17:32","slug":"%e5%93%88%e4%bd%9b%e5%a4%a7%e5%ad%a6nat-mater-%ef%bc%9a%e5%9f%ba%e8%b4%a8%e7%b2%98%e5%bc%b9%e6%80%a7%e6%8e%a7%e5%88%b6%e7%bb%84%e7%bb%87%e5%bd%a2%e6%80%81","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=244663","title":{"rendered":"\u54c8\u4f5b\u5927\u5b66Nat. Mater.\uff1a\u57fa\u8d28\u7c98\u5f39\u6027\u63a7\u5236\u7ec4\u7ec7\u5f62\u6001"},"content":{"rendered":"<p><strong>\u4e00\u3001\u3010\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p>\u7ec4\u7ec7\u5728\u7a7a\u95f4\u548c\u65f6\u95f4\u4e0a\u7684\u6a21\u5f0f\u5316\u4e0e\u8bb8\u591a\u751f\u7269\u8fc7\u7a0b\u6709\u5173\uff0c\u8fd9\u7531\u7ec6\u80de\u6570\u91cf\u3001\u5927\u5c0f\u3001\u5f62\u72b6\u548c\u4f4d\u7f6e\u7684\u53d8\u5316\u9a71\u52a8\uff0c\u5bfc\u81f4\u5bf9\u79f0\u6027\u7834\u574f\u7684\u4e0d\u7a33\u5b9a\u6027\uff0c\u5982\u5c48\u66f2\u3001\u6298\u53e0\u3001\u6495\u88c2\u3001\u51fa\u82bd\u3001\u7528\u6307\u72b6\u4f38\u5c55\u6216\u5206\u679d\u3002\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\uff0c\u7ec4\u7ec7\u7684\u5f62\u6001\u63a7\u5236\u662f\u7531\u5185\u5728\u7684\u57fa\u56e0\u8868\u8fbe\u548c\u5404\u79cd\u73af\u5883\u5316\u5b66\u548c\u673a\u68b0\u7ebf\u7d22\u6240\u8c03\u8282\u3002\u867d\u7136\u5316\u5b66\u5f62\u6001\u53d1\u751f\u68af\u5ea6\u5728\u53d1\u80b2\u4e2d\u7684\u91cd\u8981\u6027\u65e9\u5df2\u5f97\u5230\u91cd\u89c6\uff0c\u4f46\u8d8a\u6765\u8d8a\u6e05\u695a\u7684\u662f\uff0c\u7ec4\u7ec7\u548c\u5468\u56f43D\u7ec6\u80de\u5916\u57fa\u8d28\uff08ECM\uff09\u4e2d\u7684\u673a\u68b0\u7ebf\u7d22\u4e5f\u8c03\u8282\u7740\u7ec4\u7ec7\u7684\u7ec4\u7ec7\u548c\u5f62\u6001\u53d1\u751f\u3002\u786c\u5ea6\u5728\u7ec4\u7ec7\u7ec4\u7ec7\u4e2d\u7684\u4f5c\u7528\u5df2\u88ab\u5e7f\u6cdb\u7814\u7a76\u3002\u7136\u800c\uff0c\u5c3d\u7ba1ECM\u7684\u65f6\u95f4\u53d8\u5316\u7684\u7c98\u5f39\u6027\u80fd\u8d8a\u6765\u8d8a\u88ab\u8ba4\u4e3a\u662f\u5f62\u6001\u53d1\u751f\u4e2d\u7684\u4e00\u4e2a\u91cd\u8981\u89d2\u8272\uff0c\u4f46\u57fa\u8d28\u7684\u7c98\u6027\u4e0e\u5f39\u6027\u5728\u7ec4\u7ec7\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u8fd8\u4e0d\u6e05\u695a\u3002<\/p>\n<p><strong>\u4e8c\u3001\u3010\u6210\u679c\u63a0\u5f71\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u54c8\u4f5b\u5927\u5b66<\/strong><strong>L. Mahadevan<\/strong><strong>\u6559\u6388\u4e0e<\/strong><strong>David J. Mooney<\/strong><strong>\u9662\u58eb<\/strong>\u8054\u5408\u8bc1\u660e\uff0c\u5305\u88f9\u4e73\u817a\u4e0a\u76ae\u7ec6\u80de\u7403\u72b6\u7ec4\u7ec7\u7684\u57fa\u8d28\u7684\u88ab\u52a8\u7c98\u5f39\u6027\u80fd\u5728\u7a7a\u95f4\u548c\u65f6\u95f4\u4e0a\u5f15\u5bfc\u7ec4\u7ec7\u589e\u6b96\u3002\u57fa\u8d28\u7684\u7c98\u5f39\u6027\u4fc3\u4f7f\u7403\u72b6\u4f53\u7684\u5bf9\u79f0\u6027\u7834\u574f\uff0c\u5bfc\u81f4\u5165\u4fb5\u7684\u6307\u72b6\u7a81\u8d77\u7684\u5f62\u6210\uff0cYAP\u6838\u8f6c\u4f4d\u548c\u4e0a\u76ae\u5230\u95f4\u8d28\u7684\u8f6c\u53d8\uff0c\u5728\u4f53\u5916\u548c\u4f53\u5185\u90fd\u662f\u4ee5Arp2\/3\u590d\u5408\u7269\u4f9d\u8d56\u7684\u65b9\u5f0f\u8fdb\u884c\u3002\u901a\u8fc7\u5bf9\u8fd9\u4e9b\u89c2\u5bdf\u7ed3\u679c\u8fdb\u884c\u8ba1\u7b97\u5efa\u6a21\uff0c\u7814\u7a76\u4eba\u5458\u5efa\u7acb\u4e86\u4e00\u4e2a\u4e0e\u57fa\u8d28\u7c98\u5f39\u6027\u3001\u7ec4\u7ec7\u7c98\u5ea6\u3001\u7ec6\u80de\u8fd0\u52a8\u6027\u548c\u7ec6\u80de\u5206\u88c2\u7387\u6709\u5173\u7684\u5f62\u6001\u7a33\u5b9a\u6027\u76f8\u56fe\uff0c\u8be5\u76f8\u56fe\u901a\u8fc7\u751f\u5316\u68c0\u6d4b\u548c\u80a0\u9053\u7c7b\u5668\u5b98\u4f53\u5916\u5b9e\u9a8c\u5f97\u5230\u9a8c\u8bc1\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u9879\u5de5\u4f5c\u5f3a\u8c03\u4e86\u5e94\u529b\u677e\u5f1b\u673a\u5236\u5728\u7ec4\u7ec7\u751f\u957f\u52a8\u6001\u4e2d\u7684\u4f5c\u7528\uff0c\u8fd9\u662f\u5f62\u6001\u53d1\u751f\u548c\u80bf\u7624\u53d1\u751f\u7684\u4e00\u4e2a\u57fa\u672c\u8fc7\u7a0b\u3002\u8be5\u8bba\u6587\u4ee5\u9898\u4e3a\u201c<strong>Matrix viscoelasticity controls spatiotemporal tissue organization\u201d<\/strong>\u53d1\u8868\u5728\u77e5\u540d\u671f\u520a<strong>Nature Materials<\/strong>\u4e0a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-244664\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/0-2.png\" alt=\"\" width=\"600\" height=\"258\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/0-2.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/0-2-300x129.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u4e09\u3001\u3010\u6838\u5fc3\u521b\u65b0\u70b9\u3011<\/strong><\/p>\n<p>\u7814\u7a76\u5305\u88f9\u7740\u4e73\u817a\u4e0a\u76ae\u7ec6\u80de\u7403\u72b6\u7ec4\u7ec7\u7684\u57fa\u8d28\u7684\u7c98\u5f39\u6027\u80fd\u5728\u7a7a\u95f4\u548c\u65f6\u95f4\u4e0a\u5bf9\u7ec6\u80de\u7ec4\u7ec7\u589e\u6b96\u5f71\u54cd\uff1b\u660e\u786e\u4e86\u57fa\u8d28\u7684\u7c98\u5f39\u6027\u5728\u4e24\u4e2a\u5e38\u7528\u7684\u4f53\u5916\u53d1\u80b2\u548c\u75c5\u7406\u7ec4\u7ec7\u751f\u957f\u6a21\u578b\u4e2d\u8c03\u8282\u7ec4\u7ec7\u5f62\u6001\u7684\u4f5c\u7528\uff1b\u63d0\u51fa\u4e86\u4e00\u4e2a\u76f8\u56fe\u4e3a\u518d\u751f\u533b\u5b66\u4e2d\u7684\u7ec4\u7ec7\u5f62\u6001\u5b66\u63d0\u4f9b\u6307\u5bfc\u3002<\/p>\n<p><strong>\u56db\u3001\u3010\u6570\u636e\u6982\u89c8\u3011<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-244665\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/1-4.png\" alt=\"\" width=\"600\" height=\"558\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/1-4.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/1-4-300x279.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u4e00\u3001\u57fa\u8d28\u7c98\u5f39\u6027\u8c03\u8282\u4e0a\u76ae\u7ec4\u7ec7\u7684\u7ed3\u6784<\/strong><strong> \u00a9 2022 Springer Nature<\/strong><\/p>\n<p>\uff08a\uff09\u540c\u65f6\u6539\u53d8\u805a\u5408\u7269\u7684\u5206\u5b50\u91cf\u548c\u4ea4\u8054\u7a0b\u5ea6\u6539\u53d8\u7c98\u5f39\u6027\u80fd\u7684\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08b\uff09\u6240\u5f97\u85fb\u9178\u76d0\u6c34\u51dd\u80f6\u50a8\u80fd\u6a21\u91cf\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08c\uff09\u521d\u59cb\u65bd\u52a0\u7684\u5e94\u529b\u677e\u5f1b\u5230\u5176\u539f\u59cb\u503c\u7684\u4e00\u534a\u65f6\u7684\u65f6\u95f4\u5c3a\u5ea6\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08d\uff09MCF10A\u7403\u4f53\u5728\u5f39\u6027\u4e0e\u7c98\u5f39\u6027\u6c34\u51dd\u80f6\u4e2d\u751f\u957f5\u5929\u7684\u5b9e\u4f8b\u3002<\/p>\n<p>\uff08e-f\uff09\u7403\u4f53\u9762\u79ef\u548c\u5706\u5f62\u5ea6\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08g\uff09\u5728\u5f39\u6027\u548c\u7c98\u5f39\u6027\u51dd\u80f6\u4e2d\u751f\u957f\u7684MCF10A\u7ec6\u80de\u7403\u4f53\u4e2d\u78f7\u9178\u5316FAK\u5c40\u90e8\u7c98\u8fde\u7684\u5b9e\u4f8b\u3002<\/p>\n<p>\uff08h\uff09\u5728\u5f39\u6027\u51dd\u80f6\u548c\u7c98\u5f39\u6027\u51dd\u80f6\u4e2d\uff0c\u8774\u8776\u5170\u7d20\uff08\u9752\u8272\uff09\u3001Hoechst\uff08\u54c1\u7ea2\u8272\uff09\uff08\u4e0a\u6392\uff09\u548cYAP\uff08\u4e0b\u6392\uff09\u67d3\u8272\u7403\u4f53\u7684\u4ee3\u8868\u6027\u5b9e\u4f8b\u3002<\/p>\n<p>\uff08i\uff09\u6839\u636e\u6240\u793a\u533a\u57df\u7684\u6bcf\u5e45\u56fe\u50cf\u7684\u7ec6\u80de\u6838YAP\u7ec6\u80de\u767e\u5206\u6bd4\u7684\u67d3\u8272\u8fdb\u884c\u5b9a\u91cf\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-244666\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/2-4.png\" alt=\"\" width=\"600\" height=\"555\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/2-4.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/2-4-300x278.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u4e8c\u3001\u57fa\u8d28\u7c98\u5f39\u6027\u4fc3\u8fdb<\/strong><strong>EMT<\/strong><strong>\u548c\u80bf\u7624\u751f\u957f<\/strong><strong> \u00a9 2022 Springer Nature<\/strong><\/p>\n<p>\uff08a\uff09\u5728\u7c98\u5f39\u6027\u548c\u5f39\u6027\u6c34\u51dd\u80f6\u4e2d\u751f\u957f\u7684\u7403\u4f53\uff0c\u6ce2\u5f62\u86cb\u767d\uff08\u9752\u8272\uff09\u548cphalloidin\uff08\u54c1\u7ea2\u8272\uff09\u67d3\u8272\u7684\u5b9e\u4f8b\u3002<\/p>\n<p>\uff08b\uff09\u5f39\u6027\u6c34\u51dd\u80f6\u4e2d\u7403\u4f53\u5916\u73af\u548c\u7c98\u5f39\u6027\u6c34\u51dd\u80f6\u4e2d\u7684\u7403\u4f53\u6307\u72b6\u7269\u4e2d\u5e73\u5747\u6ce2\u5f62\u86cb\u767d\u5f3a\u5ea6\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08c\uff09\u5728\u7c98\u5f39\u6027\u548c\u5f39\u6027\u6c34\u51dd\u80f6\u4e2d\uff0c\u8774\u8776\u5170\u7d20\u3001Hoechst\uff08\u5de6\uff09\u548c\u7ec6\u80de\u89d2\u86cb\u767d14\uff08\u53f3\uff09\u67d3\u8272\u5448\u7403\u72b6\u3002<\/p>\n<p>\uff08d\uff09\u7403\u4f53\u5916\u73af\u5e73\u5747\u7ec6\u80de\u89d2\u86cb\u767d14\u5f3a\u5ea6\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08e-g\uff09\u5f39\u6027\u548c\u7c98\u5f39\u6027\u57fa\u8d28\u4e2d\u7403\u4f53\u4e2dSnail\u3001Slug\u6216Zeb1\u9633\u6027\u7ec6\u80de\u767e\u5206\u6bd4\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08h\uff09\u6ce8\u5c04\u542b\u6709MDA-MB-231\u4e73\u817a\u4e0a\u76ae\u7ec6\u80de\u7684\u7c98\u5f39\u6027\u548c\u5f39\u6027\u6c34\u51dd\u80f6\u7684\u5c0f\u9f20\u80bf\u7624\u4f53\u79ef\u7684\u53d8\u5316\u3002<\/p>\n<p>\uff08i\uff09MDA-MB-231\u5728\u5f39\u6027\u548c\u7c98\u5f39\u6027\u6c34\u51dd\u80f6\u4e2d\u7684phalloidin\u548cHoechst\u67d3\u8272\u7684\u4ee3\u8868\u6027\u5b9e\u4f8b\u3002<\/p>\n<p>\uff08j\uff09\u690d\u51657\u5929\u540e\uff0c\u88f8\u9f20\u4f53\u5185\u7684\u7c98\u5f39\u6027\u548c\u5f39\u6027\u6c34\u51dd\u80f6\u4e2dMCF10A\u7403\u4f53\u7684\u8774\u8776\u5170\u7d20\u548cHoechst\uff08\u5de6\uff09\u3001\u7ebf\u7c92\u4f53\uff08\u4e2d\uff09\u548c\u6ce2\u5f62\u86cb\u767d\uff08\u53f3\uff09\u67d3\u8272\u7684\u4ee3\u8868\u6027\u5b9e\u4f8b\u3002<\/p>\n<p>\uff08k\uff09\u690d\u51657\u5929\u540e\uff0c\u5f39\u6027\u548c\u7c98\u5f39\u6027\u57fa\u8d28\u7403\u4f53\u4e2dSlug\u9633\u6027\u7ec6\u80de\u767e\u5206\u6bd4\u7684\u91cf\u5316\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-244667\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/3-5.png\" alt=\"\" width=\"600\" height=\"846\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/3-5.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/3-5-213x300.png 213w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u4e09\u3001\u7403\u4f53<\/strong><strong>&#8211;<\/strong><strong>\u6750\u6599\u7684\u7269\u7406\u76f8\u4e92\u4f5c\u7528\u7684\u7406\u8bba\u6a21\u578b\u9884\u6d4b<\/strong><strong> \u00a9 2022 Springer Nature<\/strong><\/p>\n<p>\uff08a\uff09\u7ec4\u7ec7\u5728\u88ab\u52a8\u7c98\u5f39\u6027\u57fa\u8d28\u4e2d\u751f\u957f\u7684\u7406\u8bba\u7269\u7406\u6a21\u578b\u3002<\/p>\n<p>\uff08b\uff09\u5f39\u6027\u57fa\u8d28\u4e0e\u7c98\u5f39\u6027\u57fa\u8d28\u4e2d\u6a21\u62df\u7ec4\u7ec7\u751f\u957f\u7684\u793a\u4f8b\u3002<\/p>\n<p>\uff08c-d\uff09\u5bf9\u6807\u51c6\u5316\u65f6\u95f4\u5185\u7403\u4f53\u6295\u5f71\u9762\u79ef\u548c\u5706\u5f62\u5ea6\u7684\u6a21\u62df\u8fdb\u884c\u91cf\u5316\u3002<\/p>\n<p>\uff08e\uff09\u6291\u5236\u7ec6\u80de\u8fd0\u52a8\u7684\u6a21\u578b\u9884\u6d4b\u3002<\/p>\n<p>\uff08f\uff09\u4ee3\u8868\u6027\u7684\u5b9e\u4f8b\u548c5\u5929\u540e\u5728\u6709\/\u65e0\u7ec6\u80de\u7c98\u9644\u914d\u4f53RGD\u7684\u6c34\u51dd\u80f6\u4e2d\u7403\u4f53\u9762\u79ef\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08g\uff09\u7528\u4e8e\u5f71\u54cd\u7ec6\u80de\u8fd0\u52a8\u7684\u6291\u5236\u5242\u7684\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08h\uff09\u5728\u6291\u5236\u5242\u5b58\u5728\u7684\u6761\u4ef6\u4e0b\uff0c5\u5929\u540e\u7403\u4f53\u9762\u79ef\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08i\uff09\u7ec4\u7ec7\u751f\u957f\u6291\u5236\u6a21\u578b\u9884\u6d4b\u3002<\/p>\n<p>\uff08j\uff09\u4e0d\u4f7f\u7528\u6216\u4f7f\u7528\u80f8\u82f7\u6765\u6291\u5236\u7ec6\u80de\u589e\u6b96\uff0c\u4ee3\u8868\u6027\u7684\u5b9e\u4f8b\u548c\u7403\u4f53\u9762\u79ef\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08k\uff09\u5f39\u6027\u51dd\u80f6\u548c\u7c98\u5f39\u6027\u51dd\u80f6\u4e2d\u7403\u4f53\u4e2d\u589e\u6b96\u7ec6\u80de\u6570\u91cf\u548c\u5206\u5e03\u7684\u6a21\u578b\u9884\u6d4b\u548c\u5b9e\u9a8c\u7ed3\u679c\u3002<\/p>\n<p>\uff08l\uff09\u751f\u957f\u4e2d\u7684\u7ec4\u7ec7\u6253\u7834\u5bf9\u79f0\u6027\u5e76\u5728\u7c98\u5f39\u6027\u57fa\u8d28\u4e2d\u8868\u73b0\u51fa\u6307\u72b6\u7ed3\u6784\u7684\u80fd\u529b\u53d6\u51b3\u4e8e\u6574\u5408\u7d20\u7c98\u9644\u3001FAK\u78f7\u9178\u5316\u3001Rac1\u6d3b\u6027\u548cArp2\/3\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-244668\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/4-3.png\" alt=\"\" width=\"600\" height=\"743\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/4-3.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/4-3-242x300.png 242w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u56db\u3001\u751f\u957f\u548c\u5206\u652f\u7684\u8c03\u8282<\/strong><strong> \u00a9 2022 Springer Nature<\/strong><\/p>\n<p>\uff08a\uff09\u7ec4\u7ec7\u7684\u4e3b\u52a8\u8fd0\u52a8\u6027\u4e0e\u57fa\u8d28\u786c\u5ea6\u7684\u5173\u7cfb\u3002<\/p>\n<p>\uff08b-d\uff09\u5728\u8d8a\u6765\u8d8a\u786c\u7684\u5f39\u6027\u548c\u7c98\u5f39\u6027\u51dd\u80f6\u4e2d\uff0c\u7403\u4f53\u76843D\u6700\u7ec8\u65f6\u95f4\u70b9\u6a21\u62df\u56fe\u50cf\u3001\u6295\u5f71\u9762\u79ef\u548c\u5706\u5f62\u5ea6\u968f\u5f52\u4e00\u5316\u65f6\u95f4\u7684\u6f14\u53d8\u3002<\/p>\n<p>\uff08e\uff09\u901a\u8fc7\u8fdb\u4e00\u6b65\u6539\u53d8\u5f39\u6027\u548c\u7c98\u5f39\u6027\u51dd\u80f6\u7684\u4ea4\u8054\u7a0b\u5ea6\u6765\u6539\u53d8\u5b9e\u9a8c\u57fa\u8d28\u7684\u786c\u5ea6\u3002<\/p>\n<p>\uff08f\uff09\u4ee3\u8868\u6027\u7684\u5b9e\u4f8b\u548c5\u5929\u540e\u7403\u4f53\u9762\u79ef\u7684\u91cf\u5316\uff0c\u5728\u5f39\u6027\u548c\u7c98\u5f39\u6027\u57fa\u8d28\u4e2d\u7684\u786c\u5ea6\u589e\u52a0\u3002<\/p>\n<p>\uff08g\uff09\u5f39\u6027\u548c\u7c98\u5f39\u6027\u57fa\u8d28\u7684\u786c\u5ea6\u589e\u52a0\uff0c5\u5929\u540e\u7403\u4f53\u5706\u5f62\u5ea6\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08h\uff09\u4e0e\u8f6f\u7c98\u5f39\u6027\u57fa\u8d28\u76f8\u6bd4\uff0c\u5728\u521a\u6027\u7c98\u5f39\u6027\u57fa\u8d28\u4e2d\u6d88\u9664\u7ec6\u80de\u8fd0\u52a8\u65f6\u7684\u4ee3\u8868\u6027\u6a21\u578b\u6a21\u62df\u7ed3\u679c\u3002<\/p>\n<p>\uff08i\uff09\u4ee3\u8868\u6027\u7684\u5b9e\u4f8b\u548c\u5728\u8f6f\/\u786c\u7c98\u5f39\u6027\u57fa\u8d28\u4e2d\u4f7f\u7528Rac1\u548cArp2\/3\u6291\u5236\u52425\u5929\u540e\u7403\u4f53\u9762\u79ef\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08j\uff09\u5f39\u6027\u51dd\u80f6\u548c\u7c98\u5f39\u6027\u51dd\u80f6\u5728\u786c\u5ea6\u589e\u52a0\u7684\u7403\u4f53\u4e2d\u7ec6\u80de\u589e\u6b96\u7684\u6a21\u578b\u9884\u6d4b\u3002<\/p>\n<p>\uff08k\uff09\u4ee3\u8868\u6027\u7684\u5b9e\u4f8b\u548c\u5728\u5f39\u6027\u548c\u7c98\u5f39\u6027\u51dd\u80f6\u4e2d\u786c\u5ea6\u589e\u52a0\u76845\u5929\u540e\u7403\u72b6\u4f53\u4e2dEdU\u9633\u6027\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u7684\u91cf\u5316\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-244669\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/5-1.png\" alt=\"\" width=\"600\" height=\"582\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/5-1.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/5-1-300x291.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u4e94\u3001\u76f8\u4f4d\u56fe<\/strong><strong> \u00a9 2022 Springer Nature<\/strong><\/p>\n<p>\u6a21\u62df\u9884\u6d4b\u548c\u5b9e\u9a8c\u8bc1\u5b9e\uff0c\u7ec4\u7ec7\u751f\u957f\u7684\u7a33\u5b9a\u6027\u548c\u4e0d\u7a33\u5b9a\u6027\u533a\u57df\u53ef\u4ee5\u57fa\u4e8e\u4e09\u4e2a\u65e0\u91cf\u7eb2\u53d8\u91cf\u7684\u503c\u6765\u9884\u6d4b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-244670\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/6-2.png\" alt=\"\" width=\"600\" height=\"789\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/6-2.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/12\/6-2-228x300.png 228w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u516d\u3001<\/strong><strong>ECM<\/strong><strong>\u7684\u7c98\u5f39\u6027\u9a71\u52a8\u80a0\u9053\u7c7b\u5668\u5b98\u7684\u5f62\u6001\u53d8\u5316<\/strong><strong> \u00a9 2022 Springer Nature<\/strong><\/p>\n<p>\uff08a\uff09\u85fb\u9178\u76d0\u548c\u57fa\u8d28\u80f6IPNs\u5728\u7c7b\u5668\u5b98\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08b\uff09\u5f39\u6027\u548c\u7c98\u5f39\u6027\u85fb\u9178\u76d0-\u57fa\u8d28\u51dd\u80f6IPNs\u7684\u50a8\u5b58\u6a21\u91cf\u3002<\/p>\n<p>\uff08c\uff09\u5f39\u6027\u548c\u7c98\u6027\u6c34\u51dd\u80f6\u4e2d\u7684\u80a0\u9053\u5668\u5b98\u5728\u57f9\u517b7\u5929\u540e\u7684phalloidin\u548cHoechst\u67d3\u8272\u7684\u4ee3\u8868\u5b9e\u4f8b\u3002<\/p>\n<p>\uff08d-e\uff09\u5f39\u6027\u548c\u7c98\u5f39\u6027\u57fa\u8d28\u4e2d7\u5929\u5185\u7c7b\u5668\u5b98\u9762\u79ef\u548c\u5706\u5f62\u5ea6\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08f\uff097\u5929\u540e\u80a0\u9053\u5668\u5b98\u5728\u786c\u7684\u7c98\u5f39\u6027\u51dd\u80f6\u4e2d\uff0cLgr5+\u3001phalloidin\u548cHoechst\u67d3\u8272\u7684\u5b9e\u4f8b\u3002<\/p>\n<p>\uff08g\uff097\u5929\u540e\u5728\u786c\u7c98\u5f39\u6027\u51dd\u80f6\u4e2d\u5bf9\u80a0\u9053\u7c7b\u5668\u5b98\u8fdb\u884c\u6eb6\u83cc\u9176\u3001phalloidin\u548cHoechst\u67d3\u8272\u7684\u5b9e\u4f8b\u3002<\/p>\n<p>\uff08h\uff09\u76f8\u4f4d\u5bf9\u6bd4\u548cLgr5+GFP\u56fe\u50cf\u7684\u4ee3\u8868\u5b9e\u4f8b\uff0c\u4ee5\u53ca\u8f6f\/\u786c\u7c98\u5f39\u6027\u548c\u5f39\u6027\u57fa\u8d28\u4e2dGFP\u9633\u6027\u7684Lgr5+\u80a0\u9053\u5668\u5b98\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08i\uff09\u5bf9\u6bcf\u4e2a\u6761\u4ef6\u4e0b\u7684\u83cc\u843d\u5f62\u6210\u7684\u767e\u5206\u6bd4\u8fdb\u884c\u91cf\u5316\u3002<\/p>\n<p>\uff08j\uff097\u5929\u540e\u8f6f\/\u786c\u5f39\u6027\u548c\u7c98\u6027\u57fa\u8d28\u4e2d\u7684\u80a0\u9053\u7ec4\u7ec7\u7ec6\u80de\u7684phalloidin\u548cHoechst\u67d3\u8272\u5b9e\u4f8b\u3002<\/p>\n<p>\uff08k\uff09\u8f6f\/\u786c\u5f39\u6027\u548c\u7c98\u5f39\u6027\u57fa\u8d28\u4e2d\u7c7b\u5668\u5b98\u9762\u79ef\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08l\uff09EdU\u548cHoechst\u67d3\u8272\u7684\u5b9e\u4f8b\u4ee5\u53ca\u8f6f\u3001\u786c\u5f39\u6027\u548c\u7c98\u5f39\u6027\u57fa\u8d28\u4e2d\u7684\u80a0\u9053\u5668\u5b98\u7684EdU\u9633\u6027\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u3002<\/p>\n<p><strong>\u4e94\u3001\u3010\u6210\u679c\u542f\u793a\u3011<\/strong><\/p>\n<p>\u5b9e\u9a8c\u548c\u6a21\u62df\u8868\u660e\uff0c\u7c98\u5f39\u6027\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u88ab\u52a8\u7279\u6027\u53ef\u4ee5\u8c03\u8282\u7ec4\u7ec7\u5f62\u6001\u3002\u7531\u6b64\u4ea7\u751f\u7684\u5f62\u6001\u8ba9\u4eba\u8054\u60f3\u5230\u88ab\u52a8\u9a71\u52a8\u7684\u7269\u7406\u7cfb\u7edf\u4e2d\u7684\u754c\u9762\u4e0d\u7a33\u5b9a\u6027\u3002\u4f46\u5728\u751f\u547d\u7cfb\u7edf\u4e2d\u7ec6\u80de\u8fd0\u52a8\u548c\u589e\u6b96\u7684\u6d3b\u8dc3\u8fc7\u7a0b\u4ece\u6839\u672c\u4e0a\u6539\u53d8\u4e86\u754c\u9762\u7684\u4e0d\u7a33\u5b9a\u6027\uff0c\u8fd9\u4f1a\u7834\u574f\u754c\u9762\u7684\u7a33\u5b9a\uff0c\u5e76\u4e0e\u8bb8\u591a\u8fc7\u7a0b\u76f8\u5173\uff0c\u5305\u62ec\u80da\u80ce\u53d1\u751f\u3001\u80bf\u7624\u53d1\u751f\u3001\u5206\u652f\u5f62\u6001\u53d1\u751f\u548c\u8840\u7ba1\u751f\u6210\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u95f4\u8d28\u7684ECM\u6d41\u52a8\u6027\u589e\u52a0\u9a71\u52a8\u6b63\u5e38\u7684\u80da\u80ce\u6c14\u9053\u5206\u652f\uff0c\u800c\u7ec4\u7ec7\u6d41\u52a8\u6027\u589e\u52a0\u9a71\u52a8\u4f24\u53e3\u6108\u5408\u3001\u7ec4\u7ec7\u4f38\u957f\u6216\u795e\u7ecf\u5d74\u53d1\u80b2\u3002\u7814\u7a76\u7ed3\u679c\u8fd8\u8868\u660e\uff0c\u5f53\u80bf\u7624\u8fc1\u79fb\u3001\u751f\u957f\u5e76\u63a8\u52a8\u57fa\u8d28\u65f6\uff0c\u8fd9\u53ef\u80fd\u4f1a\u5bfc\u81f4\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u57fa\u8d28\u6307\u72b6\u7269\u7684\u88ab\u52a8\u751f\u6210\uff0c\u56e0\u4e3a\u57fa\u8d28\u6bd4\u5065\u5eb7\u7ec4\u7ec7\u5177\u6709\u66f4\u591a\u7684\u6db2\u4f53\u7279\u6027\u3002\u6b64\u5916\uff0c\u672c\u7814\u7a76\u5f3a\u8c03\u4e86\u7c98\u5f39\u6027\u548c\u786c\u5ea6\u5728\u7ec4\u7ec7\u751f\u957f\u8fc7\u7a0b\u4e2d\u7684\u534f\u540c\u4f5c\u7528\uff0c\u4f46\u53c8\u6709\u6240\u4e0d\u540c\u3002\u5728\u8fd9\u4e9b\u7814\u7a76\u4e2d\u4f7f\u7528\u7684\u6240\u6709\u7c98\u5f39\u6027\u51dd\u80f6\u4e2d\u90fd\u89c2\u5bdf\u5230\u4e86\u7ec4\u7ec7\u7684\u751f\u957f\u548c\u4e0d\u7a33\u5b9a\uff0c\u8fd9\u4e9b\u51dd\u80f6\u7684\u786c\u5ea6\u5f71\u54cd\u4e86\u8fd9\u4e9b\u884c\u4e3a\u7684\u7a0b\u5ea6\u3002\u7136\u800c\uff0c\u5728\u7eaf\u5f39\u6027\u51dd\u80f6\u4e2d\uff0c\u6539\u53d8\u786c\u5ea6\u7684\u5f71\u54cd\u5f88\u5c0f\uff0c\u56e0\u4e3a\u7ec4\u7ec7\u7684\u751f\u957f\u4ecd\u7136\u7f13\u6162\u548c\u7a33\u5b9a\u3002\u6700\u540e\uff0c\u9664\u4e86\u63d0\u4f9b\u4e00\u4e2a\u6846\u67b6\u6765\u7406\u89e3\u6b63\u5e38\u548c\u75c5\u7406\u72b6\u6001\u4e0b\u7684\u7ec4\u7ec7\u5f62\u6001\u548c\u7ec4\u7ec7\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u63d0\u51fa\u4e86\u4e00\u4e2a\u76f8\u56fe\u4e3a\u518d\u751f\u533b\u5b66\u4e2d\u7684\u7ec4\u7ec7\u5f62\u6001\u5b66\u63d0\u4f9b\u6307\u5bfc\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41563-022-01400-4\" target=\"_blank\" rel=\"noopener\">Matrix viscoelasticity controls spatiotemporal tissue organization<\/a> (<em>Nat. Mater. <\/em><strong>2022<\/strong>, DOI: 10.1038\/s41563-022-01400-4)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001\u3010\u5bfc\u8bfb\u3011 \u7ec4\u7ec7\u5728\u7a7a\u95f4\u548c\u65f6\u95f4\u4e0a\u7684\u6a21\u5f0f\u5316\u4e0e\u8bb8\u591a\u751f\u7269\u8fc7\u7a0b\u6709\u5173\uff0c\u8fd9\u7531\u7ec6\u80de\u6570\u91cf\u3001\u5927\u5c0f\u3001\u5f62\u72b6\u548c\u4f4d\u7f6e\u7684\u53d8\u5316\u9a71\u52a8\uff0c\u5bfc\u81f4\u5bf9\u79f0\u6027\u7834\u574f\u7684\u4e0d\u7a33\u5b9a\u6027\uff0c\u5982\u5c48\u66f2\u3001\u6298\u53e0\u3001\u6495\u88c2\u3001\u51fa\u82bd\u3001\u7528\u6307\u72b6&#8230;<\/p>\n","protected":false},"author":36791,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-244663","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/244663"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/36791"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=244663"}],"version-history":[{"count":1,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/244663\/revisions"}],"predecessor-version":[{"id":244671,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/244663\/revisions\/244671"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=244663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=244663"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=244663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}