{"id":237431,"date":"2022-05-20T08:46:22","date_gmt":"2022-05-20T00:46:22","guid":{"rendered":"\/\/m.iemloyee.com\/?p=237431"},"modified":"2022-05-20T08:46:22","modified_gmt":"2022-05-20T00:46:22","slug":"%e7%94%9f%e7%89%a9%e5%82%ac%e5%8c%96%e6%9c%80%e6%96%b0science%ef%bc%8c%e9%9d%9e%e7%94%9f%e7%89%a9%e6%80%a7c-h%e5%8f%a0%e6%b0%ae%e5%8c%96%ef%bc%81","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=237431","title":{"rendered":"\u751f\u7269\u50ac\u5316\u6700\u65b0Science\uff0c\u975e\u751f\u7269\u6027C-H\u53e0\u6c2e\u5316\uff01"},"content":{"rendered":"<p><strong>\u4e00\u3001\u3010\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p>\u5c06\u975e\u751f\u7269\u5316\u5b66\u8f6c\u5316\u5f15\u5165\u5929\u7136\u86cb\u767d\u8d28\u4ee3\u8868\u4e86\u4e00\u79cd\u5f3a\u6709\u529b\u7684\u65b9\u6cd5\uff0c\u53ef\u4ee5\u5c06\u9176\u50ac\u5316\u63a8\u8fdb\u5230\u81ea\u7136\u8fdb\u5316\u672a\u63a2\u7d22\u7684\u53cd\u5e94\u9886\u57df\u3002\u8fd9\u79cd\u7b56\u7565\u4f7f\u9176\u91cd\u65b0\u7f16\u7a0b\u80fd\u591f\u5b9e\u73b0\u5177\u6709\u6311\u6218\u6027\u7684\u533a\u57df\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u5408\u6210\u53cd\u5e94\uff0c\u540c\u65f6\u4fdd\u6301\u9057\u4f20\u53ef\u8c03\u6027\u3002\u4f8b\u5982\u9a6f\u5316\u8840\u7ea2\u7d20\u548c\u975e\u8840\u7ea2\u7d20\u91d1\u5c5e\u9176\u4ee5\u8c03\u89e3\u5361\u5bbe\u548c\u785d\u57fa\u82ef\u8f6c\u79fb\u53cd\u5e94\uff0c\u91cd\u65b0\u7f16\u7a0b\u9ec4\u7d20\u9176\u4ee5\u8fdb\u884c\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\uff0c\u4ee5\u53ca\u91cd\u7ec4\u78b3\u9178\u9150\u9176\u8fdb\u884c\u91d1\u5c5e\u6c22\u5316\u7269\u5316\u5b66\u53cd\u5e94\u3002\u5c3d\u7ba1\u53d6\u5f97\u4e86\u8fd9\u4e00\u8fdb\u5c55\uff0c\u4f46\u6709\u673a\u5408\u6210\u4e2d\u7684\u5927\u591a\u6570\u53cd\u5e94\u90fd\u6ca1\u6709\u5df2\u77e5\u7684\u751f\u7269\u5bf9\u5e94\u7269\uff0c\u800c\u8d4b\u4e88\u8fd9\u4e9b\u8f6c\u5316\u80fd\u529b\u7684\u673a\u5236\u5e76\u4e0d\u662f\u5728\u81ea\u7136\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u81ea\u7136\u5f62\u6210\u7684\u3002\u4e3a\u4e86\u5145\u5206\u53d1\u6325\u9176\u5728\u73b0\u4ee3\u5316\u5b66\u5408\u6210\u4e2d\u7684\u6f5c\u529b\uff0c\u5c06\u5408\u6210\u5316\u5b66\u4e2d\u7684\u57fa\u672c\u53cd\u5e94\u6a21\u5f0f\u5f15\u5165\u751f\u7269\u5b66\u7684\u50ac\u5316\u4f53\u7cfb\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<p><strong>\u4e8c\u3001\u3010\u6210\u679c\u63a0\u5f71\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u5361\u5185\u57fa\u6885\u9686\u5927\u5b66<\/strong><strong>Guo Yisong<\/strong><strong>\u3001\u897f\u73ed\u7259\u8d6b\u7f57\u7eb3\u5927\u5b66<\/strong><strong>Marc Garcia-Borr\u00e0s*<\/strong><strong>\u3001\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66<\/strong><strong>Huang Xiongyi<\/strong><strong>\u7b49\u4eba<\/strong>\u8054\u5408\u62a5\u9053\u4e86\u4f7f\u7528\u91cd\u7f16\u7a0b\u975e\u8840\u7ea2\u7d20\u94c1\u9176\uff0c\u901a\u8fc7\u94c1\u50ac\u5316\u7684\u81ea\u7531\u57fa\u4f20\u9012\u6765\u50ac\u5316\u975e\u751f\u7269C\uff08sp<sup>3<\/sup>\uff09\u2012H\u53e0\u6c2e\u53cd\u5e94\u3002\u8fd9\u79cd\u751f\u7269\u50ac\u5316\u8f6c\u5316\u4f7f\u7528\u9170\u80fa\u57fa\u4f5c\u4e3a\u6c22\u539f\u5b50\u63d0\u53d6\u5242\uff0c\u4f7f\u7528Fe\uff08III\uff09-N<sub>3<\/sub>\u4e2d\u95f4\u4f53\u4f5c\u4e3a\u81ea\u7531\u57fa\u6355\u83b7\u5242\u3002\u4f5c\u8005\u5efa\u7acb\u4e86\u4e00\u4e2a\u57fa\u4e8e\u70b9\u51fb\u5316\u5b66\u7684\u9ad8\u901a\u91cf\u7b5b\u9009\u5e73\u53f0\uff0c\u7528\u4e8e\u5feb\u901f\u8fdb\u5316\u9274\u5b9a\u9176\u7684\u50ac\u5316\u6027\u80fd\u3002\u6700\u7ec8\u4f18\u5316\u7684\u53d8\u79cd\u53ef\u4ee5\u50ac\u5316\u4ea7\u751f\u4e00\u7cfb\u5217\u53e0\u6c2e\u5316\u4ea7\u7269\uff0c\u603b\u8f6c\u5316\u6570\u9ad8\u8fbe10600\uff0cee\u503c\u4e3a93%\u3002\u9274\u4e8e\u6709\u673a\u5408\u6210\u4e2d\u81ea\u7531\u57fa\u4f20\u9012\u53cd\u5e94\u7684\u666e\u904d\u6027\u548c\u975e\u8840\u7ea2\u7d20\u94c1\u9176\u7684\u591a\u6837\u6027\uff0c\u7814\u7a76\u4eba\u5458\u8bbe\u60f3\u8fd9\u4e00\u53d1\u73b0\u5c06\u6fc0\u53d1\u91d1\u5c5e\u9176\u50ac\u5316\u5242\u7684\u672a\u6765\u53d1\u5c55\uff0c\u4ee5\u5b9e\u73b0\u81ea\u7136\u8fdb\u5316\u672a\u63a2\u7d22\u7684\u5408\u6210\u6709\u7528\u8f6c\u5316\u3002\u8be5\u8bba\u6587\u4ee5\u9898\u4e3a\u201c<strong>Directed evolution of nonheme iron enzymes to access abiological radical-relay C(sp<sup>3<\/sup>)\u2212H azidation\u201d<\/strong>\u53d1\u8868\u5728\u77e5\u540d\u671f\u520a<strong>Science<\/strong>\u4e0a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-237432\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/0-3.jpg\" alt=\"\" width=\"600\" height=\"265\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/0-3.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/0-3-300x133.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u4e09\u3001\u3010\u6570\u636e\u6982\u89c8\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u91d1\u5c5e\u50ac\u5316\u81ea\u7531\u57fa\u4f20\u9012\u50ac\u5316\u7684\u9176\u4fc3<\/strong><strong>C-H<\/strong><strong>\u529f\u80fd\u5316\u7684\u6982\u5ff5<\/strong><\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-237433\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/1-12.jpg\" alt=\"\" width=\"600\" height=\"496\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/1-12.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/1-12-300x248.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p><strong>\u56fe\u4e8c\u3001\u975e\u8840\u7ea2\u7d20\u94c1\u9176\u7684\u5b9a\u5411\u6f14\u5316\uff0c\u7528\u4e8e\u81ea\u7531\u57fa\u4f20\u9012\u7684<\/strong><strong>C-H<\/strong><strong>\u53e0\u6c2e\u5316\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-237434\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/2-13.jpg\" alt=\"\" width=\"600\" height=\"312\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/2-13.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/2-13-300x156.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u4e09\u3001\u9176\u4fc3<\/strong><strong>C-H<\/strong><strong>\u53e0\u6c2e\u5316\u7684\u5e95\u7269\u62d3\u5c55\u548c\u5408\u6210\u5e94\u7528<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-237435\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/3-13.jpg\" alt=\"\" width=\"600\" height=\"628\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/3-13.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/3-13-287x300.jpg 287w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u56db\u3001\u9176\u4fc3<\/strong><strong>C-H<\/strong><strong>\u53e0\u6c2e\u5316\u53cd\u5e94\u7684\u5149\u8c31\u5b66\u548c\u8ba1\u7b97\u7814\u7a76<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-237436\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/4-14.jpg\" alt=\"\" width=\"600\" height=\"674\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/4-14.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/4-14-267x300.jpg 267w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56db\u3001\u3010\u6210\u679c\u542f\u793a\u3011<\/strong><\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u7814\u7a76\u4eba\u5458\u62a5\u9053\u7684\u751f\u7269\u50ac\u5316\u7cfb\u7edf\u901a\u8fc7\u91d1\u5c5e\u50ac\u5316\u7684\u81ea\u7531\u57fa\u4e2d\u7ee7\u673a\u5236\u8fdb\u884cC(sp<sup>3<\/sup>)-H\u529f\u80fd\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u6269\u5927\u4e86\u975e\u8840\u7ea2\u7d20\u94c1\u9176\u50ac\u5316\u7684\u8303\u56f4\u3002\u6587\u4e2d\u5c55\u793a\u7684\u4f7f\u7528\u5b9a\u5411\u6f14\u5316\u975e\u8840\u7ea2\u7d20\u94c1\u9176\u4f7f\u7528\u82b3\u57faN-\u6c1f\u9170\u80fa\u4f5c\u4e3a\u5e95\u7269\u548c\u81ea\u7531\u57fa\u5f15\u53d1\u5242\u8fdb\u884c\u5bf9\u6620\u9009\u62e9\u6027\u53e0\u6c2e\u5316\u7269\u8f6c\u79fb\uff0c\u751f\u6210\u7684\u53e0\u6c2e\u57fa\u56e2\u5b89\u88c5\u5728\u90bb\u4f4d\u70f7\u57fa\u4e0a\uff0c\u53ef\u80fd\u662f\u5408\u6210\u7684\u7528\u4e8e\u751f\u7269\u6b63\u4ea4\u5076\u8054\u5316\u5408\u7269\u7684\u5f00\u7aef\u3002\u4f5c\u8005\u8ba4\u4e3a\uff0c\u5408\u6210\u5316\u5b66\u4e2d\u5404\u79cd\u81ea\u7531\u57fa\u751f\u6210\u8fc7\u7a0b\u7684\u7ed3\u5408\u4ee5\u53ca\u91d1\u5c5e\u9176\u81ea\u7531\u57fa\u6355\u83b7\u7684\u80fd\u529b\u5c06\u4e3a\u63a8\u8fdb\u81ea\u7531\u57fa\u751f\u7269\u50ac\u5316\u7684\u524d\u6cbf\u63d0\u4f9b\u5f3a\u5927\u800c\u901a\u7528\u7684\u7b56\u7565\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abj2830\" target=\"_blank\" rel=\"noopener\">Directed evolution of nonheme iron enzymes to access abiological radical-relay C(sp<sup>3<\/sup>)\u2212H azidation<\/a> (<em>Science <\/em><strong>2022<\/strong>, <em>376<\/em>, 869-874)<\/p>\n<p>\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1a<a href=\"mailto:tougao@cailiaoren.com\">tougao@cailiaoren.com<\/a><\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001\u3010\u5bfc\u8bfb\u3011 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