{"id":236797,"date":"2022-05-07T09:30:38","date_gmt":"2022-05-07T01:30:38","guid":{"rendered":"\/\/m.iemloyee.com\/?p=236797"},"modified":"2022-05-07T14:20:27","modified_gmt":"2022-05-07T06:20:27","slug":"%e9%a9%ac%e6%99%ae%e6%89%80%e4%b8%80%e6%b0%a7%e5%8c%96%e4%ba%8c%e6%b0%ae%e5%82%ac%e5%8c%96%e5%90%88%e6%88%90%e9%85%9a%e7%b1%bb-%e7%99%bb%e4%b8%8anature","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=236797","title":{"rendered":"\u9a6c\u666e\u6240\u4e00\u6c27\u5316\u4e8c\u6c2e\u50ac\u5316\u5408\u6210\u915a\u7c7b \u767b\u4e0aNature"},"content":{"rendered":"<section>\n<p><strong><b>[\u5bfc\u8bfb]<\/b><\/strong><\/p>\n<p>\u5f00\u53d1\u80fd\u591f\u4f7f\u4e00\u6c27\u5316\u4e8c\u6c2e(N<sub>2<\/sub>O)\u91cd\u65b0\u589e\u503c\u7684\u50ac\u5316\u5316\u5b66\u5de5\u827a\u662f\u51cf\u8f7b\u5176\u6392\u653e\u6240\u5e26\u6765\u7684\u73af\u5883\u5a01\u80c1\u7684\u6709\u5438\u5f15\u529b\u7684\u7b56\u7565\u3002\u4f20\u7edf\u4e0a\uff0cN<sub>2<\/sub>O\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u60f0\u6027\u5206\u5b50\uff0c\u7531\u4e8e\u5176\u6d3b\u5316\u6240\u9700\u7684\u82db\u523b\u6761\u4ef6\uff08&gt;150\u2009\u00b0C\uff0c50-200\u2009bar\uff09\uff0c\u6709\u673a\u5316\u5b66\u5bb6\u96be\u4ee5\u5c06\u5176\u7528\u4f5c\u6c27\u5316\u5242\u6216\u6c27\u539f\u5b50\u8f6c\u79fb\u8bd5\u5242\u3002<\/p>\n<p><strong><b>[\u6210\u679c\u63a0\u5f71]<\/b><\/strong><\/p>\n<p><strong><b>\u5fb7\u56fd\u9a6c\u514b\u65af\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240Josep Cornella\u8bfe\u9898\u7ec4\u62a5\u544a\u4e86\u5728\u6e29\u548c\u6761\u4ef6\u4e0b\uff08\u5ba4\u6e29\uff0c1.5-2\u2009bar N<\/b><\/strong><strong><sub><b>2<\/b><\/sub><\/strong><strong><b>O\uff09\u5c06N<\/b><\/strong><strong><sub><b>2<\/b><\/sub><\/strong><strong><b>O\u63d2\u5165Ni-C\u952e\uff0c\u4ece\u800c\u63d0\u4f9b\u6709\u4ef7\u503c\u7684\u915a\u5e76\u91ca\u653e\u826f\u6027N<\/b><\/strong><strong><sub><b>2<\/b><\/sub><\/strong><strong><b>\u3002 <\/b><\/strong>\u8fd9\u79cd\u4ece\u6839\u672c\u4e0a\u4e0d\u540c\u7684\u6709\u673a\u91d1\u5c5eC-O\u952e\u5f62\u6210\u6b65\u9aa4\u4e0d\u540c\u4e8e\u5f53\u524d\u57fa\u4e8e\u8fd8\u539f\u6d88\u9664\u7684\u7b56\u7565\uff0c\u5e76\u4e3a\u5c06\u82b3\u57fa\u5364\u5316\u7269\u8f6c\u5316\u4e3a\u82ef\u915a\u63d0\u4f9b\u4e86\u53e6\u4e00\u79cd\u50ac\u5316\u65b9\u6cd5\u3002\u8be5\u8fc7\u7a0b\u901a\u8fc7Ni\u4e2d\u5fc3\u7684\u57fa\u4e8e\u8054\u5421\u5576\u7684\u914d\u4f53\u8fdb\u884c\u50ac\u5316\u3002\u8be5\u65b9\u6cd5\u7a33\u5065\u3001\u6e29\u548c\u4e14\u9009\u62e9\u6027\u9ad8\uff0c\u4e5f\u80fd\u591f\u9002\u5e94\u78b1\u57fa\u654f\u611f\uff0c\u5e76\u5141\u8bb8\u4ece\u9ad8\u5ea6\u5b98\u80fd\u5316\u7684\u82b3\u57fa\u5364\u5316\u7269\u5408\u6210\u82ef\u915a\u3002\u5c3d\u7ba1\u8be5\u65b9\u6cd5\u6ca1\u6709\u63d0\u4f9b\u7f13\u89e3N<sub>2<\/sub>O\u6392\u653e\u7684\u89e3\u51b3\u65b9\u6848\uff0c\u4f46\u5b83\u4ee3\u8868\u4e86\u5c06\u4e30\u5bcc\u7684N<sub>2<\/sub>O\u4f5c\u4e3aO\u6e90\u8fdb\u884c\u6e29\u548c\u91cd\u65b0\u4f30\u503c\u7684\u53cd\u5e94\u6027\u84dd\u56fe\u3002\u76f8\u5173\u8bba\u6587\u4ee5\u9898\u4e3a\uff1a\u201c<strong><em><i>Catalytic synthesis of phenols with nitrous oxide<\/i><\/em><\/strong>\u201d\u53d1\u8868\u5728<strong><em><i>Nature<\/i><\/em><\/strong>\u4e0a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-236798\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-21.png\" alt=\"\" width=\"743\" height=\"229\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-21.png 743w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-21-300x92.png 300w\" sizes=\"(max-width: 743px) 100vw, 743px\" \/><\/p>\n<p><strong><b>[\u6838\u5fc3\u521b\u65b0\u70b9]<\/b><\/strong><\/p>\n<ul>\n<li>\u672c\u5de5\u4f5c\u5c55\u793a\u4e86\u4e00\u79cd\u72ec\u7279\u7684\u57fa\u672c\u6709\u673a\u91d1\u5c5e\u6b65\u9aa4\uff0c\u63d0\u51fa\u4e86N<sub>2<\/sub>O\u4f5c\u4e3a\u4e00\u79cd\u7528\u4e8e\u6709\u673a\u5408\u6210\u7684\u7eff\u8272\u3001\u6e29\u548c\u548c\u5316\u5b66\u9009\u62e9\u6027\u7684O\u539f\u5b50\u63d2\u5165\u8bd5\u5242\u7684\u50ac\u5316\u65b9\u6848\u3002<\/li>\n<li>\u8be5\u50ac\u5316\u4f53\u7cfb\u5177\u6709\u7528\u4e8eNi\u4e2d\u5fc3\u7684\u7535\u5b50\u4e0d\u5bf9\u79f0\u4e09\u9f7f\u8054\u5421\u5576\u914d\u4f53(L50)\uff0c\u53ef\u9009\u62e9\u6027\u5730\u5f62\u6210C-O\u952e\u3002<\/li>\n<li>\u6b64\u5916\uff0c\u672c\u5de5\u4f5c\u8bc1\u660e\u4e86\u83b7\u53d6\u4ee5N<sub>2<\/sub>O\u4e3a\u552f\u4e00\u6c27\u539f\u5b50\u6765\u6e90\u7684\u76f8\u5173\u836f\u7269\u7684\u53ef\u884c\u6027\u3002<\/li>\n<\/ul>\n<p><strong><b>\u00a0<\/b><\/strong><\/p>\n<p><strong><b>\u00a0<\/b><\/strong><\/p>\n<p><strong><b>[\u6570\u636e\u6982\u89c8]<\/b><\/strong><\/p>\n<ul>\n<li><b><\/b><strong><b>N<\/b><\/strong><strong><sub><b>2<\/b><\/sub><\/strong><strong><b>O\u4f5c\u4e3a\u7eff\u8272\u6c27\u5316\u5242\u5728\u82ef\u915a\u884d\u751f\u7269\u5408\u6210\u4e2d\u7684\u76f8\u5173\u6027<\/b><\/strong><\/li>\n<\/ul>\n<p><strong><b>\u00a0<\/b><\/strong><\/p>\n<p>\u6e29\u5ba4\u6c14\u4f53\u6392\u653e\u7684\u65e5\u76ca\u589e\u52a0\u662f\u5168\u7403\u6027\u7684\u73af\u5883\u5a01\u80c1\uff0c\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\u7684\u6218\u7565\u4e00\u76f4\u662f\u8fd1\u5e74\u6765\u5bc6\u96c6\u7814\u7a76\u7684\u91cd\u70b9\u3002N<sub>2<\/sub>O\u3001\u8fc7\u6c27\u5316\u7269\u6216\u6c27\u6c14\u5bf9O\u63d2\u5165\u5404\u79cdM-C(sp<sup>2<\/sup>)\u952e\u7684\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u6709\u673a\u91d1\u5c5eBaeyer\u2013Villiger (OMBV)\u578b\u673a\u7406\u662f\u901a\u8fc7\u9634\u79bb\u5b50\u78b3\u5411\u914d\u4f4d\u7684O\u539f\u5b50\u8fc1\u79fb\uff0c\u5f62\u6210M-O-C\u952e\u3002<strong><b>\u57fa\u4e8e\u8fd9\u79cd\u53cd\u5e94\u6027\uff0c\u672c\u5de5\u4f5c\u65e8\u5728\u91ca\u653eN<\/b><\/strong><strong><sub><b>2<\/b><\/sub><\/strong><strong><b>O\u4f5c\u4e3aO\u539f\u5b50\u6e90\u5728\u915a\u7c7b\u50ac\u5316\u5408\u6210\u4e2d\u7684\u6839\u672c\u4e0d\u540c\u7684\u6f5c\u529b\u5728\u5178\u578b\u7684\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u82b3\u57fa\u5364\u5316\u7269\u5408\u6210\u82ef\u915a\u4e2d\uff0cC(sp<\/b><\/strong><strong><sup><b>2<\/b><\/sup><\/strong><strong><b>)-O\u952e\u5f62\u6210\u6b65\u9aa4\u662f\u901a\u8fc7\u4e0e\u4eb2\u6838O\u6e90\u7684\u6210\u719f\u914d\u4f53\u4ea4\u6362\u8fdb\u884c\u7684<\/b><\/strong>\u3002\u5728\u7528\u82b3\u57fa\u8fd8\u539f\u6d88\u9664\u65f6\uff0c\u5f62\u6210\u6240\u9700\u7684C(sp<sup>2<\/sup>)-O\u952e\uff0c\u800c\u91d1\u5c5e\u4e2d\u5fc3\u88ab\u53cc\u500d\u8fd8\u539f\uff08<strong>\u56fe1b\uff0c\u5de6<\/strong>\uff09\u3002\u5728\u8fd9\u4e9b\u60c5\u51b5\u4e0b\uff0cO\u7684\u6765\u6e90\u901a\u5e38\u662fH<sub>2<\/sub>O\u6216\u8d28\u5b50O\u57fa\u4eb2\u6838\u8bd5\u5242\u4e0e\u4ea7\u751f\u76f8\u5e94\u82ef\u915a\u7684\u78b1\u7684\u7ec4\u5408\u3002\u5728\u672c\u6587\u63d0\u51fa\u7684\u66ff\u4ee3\u50ac\u5316\u5faa\u73af\u4e2d\uff0cC(sp<sup>2<\/sup>)-O\u952e\u5f62\u6210\u7684\u57fa\u672c\u6b65\u9aa4\u5229\u7528\u4e86OMBV\u578b\u673a\u5236\uff1a\u5728N<sub>2<\/sub>O\u4e0e\u91d1\u5c5e\u4e2d\u5fc3\u914d\u4f4d\u65f6\uff0c\u4eb2\u7535\u5b50O\u6700\u7ec8\u63d2\u5165M\u2012C\u952e \uff0c\u540c\u65f6\u5f62\u6210N<sub>2<\/sub>\uff08<strong>\u56fe1b\uff0c\u53f3<\/strong>\uff09\u3002\u4e0e\u4f20\u7edf\u7684\u915a\u7c7b\u5408\u6210\u76f8\u6bd4\uff0cC\u2012O\u952e\u5f62\u6210\u540e\uff0c\u91d1\u5c5e\u4e2d\u5fc3\u7684\u6c27\u5316\u6001\u4fdd\u6301\u4e0d\u53d8\uff0c\u56e0\u6b64\u9700\u8981\u5916\u90e8\u8fd8\u539f\u5242\u6765\u5173\u95ed\u5faa\u73af\u3002\u4e3a\u4e86\u534f\u8c03\u8fd9\u4e00\u8fd8\u539f\u8fc7\u7a0b\uff0c\u672c\u5de5\u4f5c\u5c06\u6ce8\u610f\u529b\u96c6\u4e2d\u5728Ni\u53ca\u5176\u901a\u8fc7\u5355\u7535\u5b50\u8f6c\u79fb\u5728\u4e0d\u540c\u6c27\u5316\u6001\u4e4b\u95f4\u8fdb\u884c\u673a\u52a8\u7684\u80fd\u529b\u4e0a\u3002\u5728\u8fd9\u91cc\uff0c<strong><b>\u672c\u5de5\u4f5c\u8bc1\u660e\u4e86\u4e00\u79cd\u7528\u6709\u673a\u91d1\u5c5e\u914d\u5408\u7269\u6d3b\u5316N<\/b><\/strong><strong><sub><b>2<\/b><\/sub><\/strong><strong><b>O\u7684\u673a\u68b0\u5f15\u5bfc\u65b9\u6cd5\u5bfc\u81f4\u4f7f\u7528N<\/b><\/strong><strong><sub><b>2<\/b><\/sub><\/strong><strong><b>O\u4f5c\u4e3a\u4eb2\u7535O\u6e90\u4ece\u82b3\u57fa\u5364\u5316\u7269\u4e2d\u6e29\u548c\u4e14\u9009\u62e9\u6027\u5730\u50ac\u5316\u5408\u6210\u9ad8\u4ef7\u503c\u915a\u7c7b\u7684\u53d1\u5c55<\/b><\/strong>\u3002\u6e29\u548c\u7684\u6761\u4ef6\uff0825\u00b0C \u548c1.5-2\u2009atm\uff09\u5141\u8bb8\u5bb9\u7eb3\u5404\u79cd\u5b98\u80fd\u56e2\uff0c\u5305\u62ec\u78b1\u57fa\u654f\u611f\u90e8\u5206\uff0c\u4ece\u800c\u4e3a\u5f53\u524d\u6280\u672f\u63d0\u4f9b\u6b63\u4ea4\u7b56\u7565\uff08<strong>\u56fe 1c<\/strong>\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-236799\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-22.png\" alt=\"\" width=\"696\" height=\"582\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-22.png 696w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-22-300x251.png 300w\" sizes=\"(max-width: 696px) 100vw, 696px\" \/><\/p>\n<p><strong>\u56fe1<\/strong>. N<sub>2<\/sub>O\u4f5c\u4e3a\u7eff\u8272\u6c27\u5316\u5242\u5728\u82ef\u915a\u884d\u751f\u7269\u5408\u6210\u4e2d\u7684\u76f8\u5173\u6027\u00a9 2022 Springer Nature Limited<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><b><\/b><strong><b>\u521d\u6b65\u53d1\u73b0\u3001\u914d\u4f53\u4f18\u5316\u548c\u6f5c\u5728\u4e2d\u95f4\u4f53<\/b><\/strong><\/li>\n<\/ul>\n<p><strong><b>\u00a0<\/b><\/strong><\/p>\n<p>\u4e3a\u4e86\u7814\u7a76M-C(sp<sup>2<\/sup>)\u6c27\u5316\u7684\u53ef\u884c\u6027\uff0c\u672c\u5de5\u4f5c\u4ece\u4e4b\u524d\u7684\u5de5\u4f5c\u4e2d\u6c72\u53d6\u7075\u611f\uff0c\u5176\u4e2dN<sub>2<\/sub>O\u88ab\u8bc1\u660e\u53ef\u4ee5\u4e0e\u67d0\u4e9b\u81a6-Ni(II) \u914d\u5408\u7269\u53cd\u5e94\u3002\u4e3a\u6b64\uff0c\u672c\u5de5\u4f5c\u5408\u6210\u4e86\u6c27\u5316\u52a0\u6210\u4ea7\u7269<strong><b>4<\/b><\/strong>\uff0c\u5e76\u7814\u7a76\u4e86\u5176\u4e0eN<sub>2<\/sub>O\u7684\u53cd\u5e94\u6027\uff08<strong>\u56fe2a<\/strong>\uff09\u3002\u6b63\u5982\u9884\u671f\u7684\u90a3\u6837\uff0c\u5f53\u5728\u6c29\u6c14\u4e0b\u6eb6\u89e3\u5728DMA\u4e2d\u65f6\uff0c4\u4e3b\u8981\u5411\u540c\u6e90\u5076\u8054(<strong><b>5<\/b><\/strong>)\u5feb\u901f\u5206\u89e3\uff0c\u4ec5\u68c0\u6d4b\u5230\u75d5\u91cf\u7684\u539f\u578b\u8131\u91d1\u5c5e(<strong><b>6<\/b><\/strong>)\uff08\u8def\u5f84a\uff09\u3002\u8fd9\u79cd\u53cd\u5e94\u6027\u4f1a\u56e0Zn\u7b49\u8fd8\u539f\u5242\u7684\u5b58\u5728\u800c\u52a0\u5267\uff08\u8def\u5f84b\uff09\u3002<strong><b>\u7136\u800c\uff0c\u5f53\u6c29\u6c14\u6c1b\u88abN<\/b><\/strong><strong><sub><b>2<\/b><\/sub><\/strong><strong><b>O\u53d6\u4ee3\u65f6\uff0c4\u6eb6\u6db2\u7684\u9c9c\u7ea2\u8272\u4ecd\u7136\u5b58\u5728\uff0c\u56e0\u6b64\u8868\u660e\u5206\u89e3\u901f\u5ea6\u8f83\u6162<\/b><\/strong>\u3002\u5728\u9178\u6027\u540e\u5904\u7406\u540e\uff0c\u89c2\u5bdf\u5230\u82ef\u915a<strong><b>7<\/b><\/strong>\u7684\u4ea7\u7387\u4e3a15%\u3002\u7136\u800c\uff0c\u5f53\u5728\u8fd8\u539f\u5242\u5b58\u5728\u4e0b\u8fdb\u884c\u76f8\u540c\u7684\u53cd\u5e94\u65f6\uff0c\u89c2\u5bdf\u5230<strong><b>7<\/b><\/strong>\u7684\u4ea7\u7387\u663e\u7740\u66f4\u9ad8\uff0c\u5f53\u4f7f\u7528Zn\u548cNaI\u7684\u7ec4\u5408\u65f6\uff0c\u4ea7\u7387\u4e3a73%\uff08\u8def\u5f84d\uff09\u3002<strong><b>\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u4f7f\u7528\u82b3\u57fa\u5364\u5316\u7269\u524d\u4f53\u5f00\u53d1\u57fa\u4e8e\u954d\u50ac\u5316\u7684\u8fd8\u539f\u50ac\u5316\u65b9\u6848\u7684\u53ef\u884c\u6027<\/b><\/strong>\u3002\u4ece\u672c\u5de5\u4f5c\u5e7f\u6cdb\u7684\u914d\u4f53\u8c03\u67e5\u4e2d\uff0c\u5f88\u660e\u663e\uff0c\u5177\u67092-\u53d6\u4ee3\u8054\u5421\u5576\u4e00\u822c\u6a21\u5f0f\u7684\u4e09\u9f7f\u6c2e\u5316\u914d\u4f53\u5bf9\u4e8e\u83b7\u5f97\u50ac\u5316\u6d3b\u6027\u81f3\u5173\u91cd\u8981\uff0c\u4e09\u8054\u5421\u5576(L18)\u548c6-\u5421\u5511\u57fa-2,2&#8242;-\u8054\u5421\u5576\uff08L50\uff09\u63d0\u4f9b\u6700\u9ad8\u4ea7\u91cf<strong><b>9<\/b><\/strong>\uff08<strong>\u56fe2b<\/strong>\uff09\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u672c\u5de5\u4f5c\u5efa\u8bae\u5728OMBV\u53cd\u5e94\u63d0\u4f9b\u7684\u4e24\u79cd\u6781\u7aef\u53ef\u80fd\u6027\u4e4b\u95f4\u7684\u8fde\u7eed\u4f53\u4e2d\uff0c\u5728Ar\u8fc1\u79fb\u4e4b\u524d\uff0cN<sub>2<\/sub>O\u5728d9\u914d\u5408\u7269\u4e2d\u7684\u6c27\u63d2\u5165\u503e\u5411\u4e8e\u5f62\u6210M-O\u952e\u548cN<sub>2<\/sub>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-236800\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-23.png\" alt=\"\" width=\"625\" height=\"506\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-23.png 625w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-23-300x243.png 300w\" sizes=\"(max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><strong>\u56fe2.<\/strong>\u00a0\u521d\u6b65\u53d1\u73b0\u3001\u914d\u4f53\u4f18\u5316\u548c\u6f5c\u5728\u4e2d\u95f4\u4f53\u00a9 2022 Springer Nature Limited<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><b><\/b><strong><b>\u91cd\u65b0\u8bc4\u4f30<\/b><\/strong><strong><b>\u915a\u7c7b\u50ac\u5316\u5408\u6210<\/b><\/strong><strong><b>\u91c7\u7528<\/b><\/strong><strong><b>N<\/b><\/strong><strong><sub><b>2<\/b><\/sub><\/strong><strong><b>O\u4f5c\u4e3a<\/b><\/strong><strong><b>\u6c27<\/b><\/strong><strong><b>\u6e90<\/b><\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong><b>\u672c\u5de5\u4f5c\u63a5\u4e0b\u6765\u501f\u52a9\u4f18\u5316\u7684\u50ac\u5316\u4f53\u7cfb\uff0c\u521d\u6b65\u7814\u7a76\u4e86\u82b3\u57fa\u5364\u5316\u7269\u5bf9\u5e94\u7269\u7684\u8303\u56f4<\/b><\/strong>\u3002\u5982<strong>\u56fe3<\/strong>\u6240\u793a\uff0c\u5728\u5bf9\u4f4d\uff08<strong><b>9<\/b><\/strong>, <strong><b>15<\/b><\/strong>\u548c<strong><b>16<\/b><\/strong>\uff09\u548c\u95f4\u4f4d\uff08<strong><b>17-19<\/b><\/strong>\uff09\u4f4d\u7f6e\u5747\u5e26\u6709\u5176\u4ed6\u5364\u7d20\u7684\u82b3\u57fa\u7898\u5316\u7269\u4ee5\u4f18\u5f02\u7684\u4ea7\u7387\u987a\u5229\u63d0\u4f9b\u76f8\u5e94\u7684\u82ef\u915a\u3002CF<sub>3<\/sub>(<strong><b>7<\/b><\/strong>)\u3001\u916e(<strong><b>20<\/b><\/strong>)\u3001\u916f(<strong><b>21<\/b><\/strong>\u548c<strong><b>24<\/b><\/strong>) \u6216\u8148(<strong><b>22-23<\/b><\/strong>)\u7b49\u5438\u7535\u5b50\u57fa\u56e2\u7684\u5b58\u5728\u5bf9C-O\u952e\u7684\u5f62\u6210\u6ca1\u6709\u4efb\u4f55\u56f0\u96be\u3002\u4f9b\u7535\u5b50\u53d6\u4ee3\u57fa\uff0c\u4f8b\u5982\u70f7\u57fa(<strong><b>25<\/b><\/strong>)\u3001\u82b3\u57fa(<strong><b>26<\/b><\/strong>)\uff0c\u751a\u81f3\u7532\u6c27\u57fa\u548c\u786b\u7532\u57fa(<strong><b>27<\/b><\/strong>\u548c<strong><b>28<\/b><\/strong>)\uff0c\u4ee5\u826f\u597d\u7684\u6536\u7387\u63d0\u4f9b\u82ef\u915a\u3002\u6b64\u5916\uff0c\u5177\u6709\u82c4\u57faC-H\u952e\u7684\u82b4\u884d\u751f\u7269(<strong><b>29<\/b><\/strong>)\u4e5f\u9002\u7528\u4e8e\u82ef\u915a\u5408\u6210\uff0c\u5c3d\u7ba1\u4ea7\u7387\u4e3a38%\u3002\u8fd8\u539f\u8026\u5408\u7684\u4e00\u4e2a\u7ecf\u5178\u7279\u5f81\u662f\u90bb\u4f4d\u7684\u7a7a\u95f4\u4f4d\u963b\u4f1a\u963b\u788d\u53cd\u5e94\u6027\u3002\u4e8b\u5b9e\u4e0a\uff0c\u7531\u831a\u6ee1\u916e(<strong><b>31<\/b><\/strong>)\u548c1-\u6c2f-2-\u7898\u82ef(30)\u884d\u751f\u7269\u5f62\u6210\u7684C-O\u952e\u5bfc\u81f4\u4ea7\u7387\u7565\u6709\u4e0b\u964d\u3002<strong><b>\u4e0e30\u76f8\u6bd4\uff0c32\u7684\u4ea7\u7387\u4e3a 79%\uff0c\u8bf4\u660e\u90bb\u4f4dOMe\u548cNi\u4e2d\u5fc3\u53ef\u80fd\u4ea7\u751f\u6709\u76ca\u7684\u87af\u5408\u4f5c\u7528<\/b><\/strong>\u3002<strong><b>28<\/b><\/strong>\u53cd\u5e94\u4e2d\u4e9a\u781c\u6536\u73877%\u7684\u89c2\u5bdf\u548c\u82b4\u9187<strong><b>29<\/b><\/strong>\u7684\u4f4e\u4ea7\u7387\u8868\u660e\uff0c\u82b4\u9187<strong><b>29<\/b><\/strong>\u7684\u6c27\u63d2\u5165\u6b65\u9aa4\u662f\u5411OMBV\u578b\u53cd\u5e94\u5047\u5b9a\u7684\u8fde\u7eed\u4f53\u4e2d\u7684\u6c27\/\u6c27\u8def\u5f84\u65b9\u5411\u8fdb\u884c\u3002\u5728\u53cd\u5e94\u5b8c\u6210<strong><b>7<\/b><\/strong>\u3001<strong><b>9<\/b><\/strong>\u3001<strong><b>18<\/b><\/strong>\u3001<strong><b>25<\/b><\/strong>\u00a0\u548c<strong><b>34<\/b><\/strong>\u540e\uff0c\u5728\u9876\u90e8\u7a7a\u95f4\u4f7f\u7528\u6c14\u76f8\u8272\u8c31-\u70ed\u5bfc\u68c0\u6d4b\u5668\u68c0\u6d4bN<sub>2<\/sub>\uff08<strong>\u56fe3<\/strong>\uff09\u3002\u5f53\u6eb6\u5242\u4e0a\u7684\u6c27\u6807\u8bb0\u4e3a\uff08[<sup>18<\/sup>O]DMF\uff0c25% <sup>18<\/sup>O\uff09\u65f6\uff0c9\u4e2d\u6ca1\u6709\u63ba\u5165<sup>18<\/sup>O\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5f53\u4f7f\u7528 N<sup>15<\/sup>N<sup>18<\/sup>O\uff0845% <sup>18<\/sup>O\uff09\u65f6\uff0c9\u4e2d\u7684O\u670922%\u00b11\u88ab\u6807\u8bb0\u3002 <strong><b>\u603b\u4e4b\uff0c\u8fd9\u4e9b\u6570\u636e\u8868\u660eN<\/b><\/strong><strong><sub><b>2<\/b><\/sub><\/strong><strong><b>O\u662fO\u7684\u6765\u6e90<\/b><\/strong>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-236801\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-25.png\" alt=\"\" width=\"702\" height=\"568\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-25.png 702w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/05\/\u56fe\u7247-25-300x243.png 300w\" sizes=\"(max-width: 702px) 100vw, 702px\" \/><\/p>\n<p><strong>\u56fe3. <\/strong>N<sub>2<\/sub>O\u4f5c\u4e3aO\u6e90\u5728\u915a\u7c7b\u50ac\u5316\u5408\u6210\u4e2d\u7684\u91cd\u4f30\u00a9 2022 Springer Nature Limited<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><b><\/b><strong><b>\u50ac\u5316<\/b><\/strong><strong><b>\u5b9e\u9a8c\u65b9\u6848\u7684<\/b><\/strong><strong><b>\u8303\u56f4\u548c\u5e94\u7528<\/b><\/strong><\/li>\n<\/ul>\n<p><strong><b>\u00a0<\/b><\/strong><\/p>\n<p><strong><b>\u82b3\u57fa\u7898\u5316\u7269\u7684\u76f8\u540c\u4f18\u5316\u53cd\u5e94\u6761\u4ef6\u5141\u8bb8\u5f62\u6210\u66f4\u5bb9\u6613\u83b7\u5f97\u548c\u5e02\u552e\u7684\u82b3\u57fa\u6eb4\u5316\u7269\u7684C-O\u952e\u3002\u7136\u800c\uff0c\u9700\u8981\u5438\u7535\u5b50\u53d6\u4ee3\u57fa\u624d\u80fd\u4f7fC(sp<\/b><\/strong><strong><sup><b>2<\/b><\/sup><\/strong><strong><b>)-Br\u88c2\u89e3\u53d1\u751f\u3002<\/b><\/strong>\u4ece\u8fd9\u4e2a\u610f\u4e49\u4e0a\u8bf4\uff0c\u53ef\u4ee5\u4ee5\u9ad8\u4ea7\u7387\u83b7\u5f97\u5bf9\u4f4d\u542b\u6709CF<sub>3<\/sub>(<strong><b>7<\/b><\/strong>)\u3001Ac(<strong><b>20<\/b><\/strong>)\u548cCN(<strong><b>22<\/b><\/strong>)\u7684\u915a\u7c7b\u4ee5\u53ca\u5bf9\u7f9f\u57fa\u82ef\u7532\u9178\u916f(21)\uff08<strong>\u56fe4a<\/strong>\uff09\u3002\u4e0e\u836f\u7528\u76f8\u5173\u7684\u82ef\u915e\u4e5f\u987a\u5229\u8f6c\u5316\u4e3a\u82ef\u915a(42)\uff0c\u56e0\u6b64\u63d0\u4f9b\u4e86\u4e00\u79cd\u5408\u6210\u8fd9\u79cd\u7ed3\u6784\u5355\u5143\u7684\u65b9\u6cd5\uff0c\u8fd9\u6bd4\u65e9\u671f\u6587\u732e\u62a5\u9053\u7684\u6b65\u9aa4\u51cf\u5c11\u4e86\u4e09\u4e2a\u3002\u901a\u8fc7\u6d4b\u8bd5\u5e26\u6709\u654f\u611f\u90e8\u5206\u5b98\u80fd\u5316\u7684\u590d\u6742\u82b3\u57fa\u5364\u5316\u7269\u3002\u4f8b\u5982\uff0c\u4e00\u79cd\u542b\u6709\u5927\u91cf\u6613\u4e8e\u4ea7\u751fHAT\u7684\u5f31C-H\u952e\u7684\u6069\u683c\u5217\u51c0\uff08empagliflozin\uff09\u884d\u751f\u7269\uff0c\u4ee5\u8f83\u9ad8\u7684\u4ea7\u7387\u987a\u5229\u8f6c\u5316\u4e3a\u76f8\u5e94\u7684\u82ef\u915a(<strong><b>46<\/b><\/strong>)\uff08<strong>\u56fe4b<\/strong>\uff09\u3002\u5929\u7136\u4ea7\u7269\u4e01\u9999\u915a\u7684\u916f\u884d\u751f\u7269\u4ee584%\u7684\u6536\u7387\u63d0\u4f9b\u6240\u9700\u7684\u82ef\u915a(<strong><b>47<\/b><\/strong>)\uff0c\u7a81\u51fa\u4e86\u8be5\u8fc7\u7a0b\u76f8\u5bf9\u4e8e\u901a\u8fc7\u91d1\u5c5e-\u6c27\u4ee3\u9014\u5f84\u7684\u66ff\u4ee3\u6c27\u5316\u7684\u9ad8\u5316\u5b66\u9009\u62e9\u6027\u3002<strong><b>\u4e00\u4e2a\u66f4\u5f15\u4eba\u6ce8\u76ee\u7684\u4f8b\u5b50\u662f\u5df4\u591a\u6614\u82ac(68)\u7684\u5408\u6210\uff0c\u5b83\u662f\u4e00\u79cd\u6297\u4e73\u817a\u764c\u548c\u80f0\u817a\u764c\u7684\u5019\u9009\u836f\u7269<\/b><\/strong>\u3002\u4e09\u79cd\u915a\u7c7b\u7ed3\u6784\u5355\u5143\u53ef\u4ee5\u4ece\u6bcd\u4f53\u5364\u5316\u7269\u4e2d\u4ee5\u826f\u597d\u7684\u6536\u7387\u5feb\u901f\u83b7\u5f97(<strong><b>64-66<\/b><\/strong>)\u3002 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