{"id":236344,"date":"2022-04-30T06:21:10","date_gmt":"2022-04-29T22:21:10","guid":{"rendered":"\/\/m.iemloyee.com\/?p=236344"},"modified":"2022-04-29T17:22:14","modified_gmt":"2022-04-29T09:22:14","slug":"%e7%9c%8b%e9%9f%a9%e5%9b%bd%e6%b7%91%e6%98%8e%e5%a5%b3%e5%ad%90%e5%a4%a7%e5%ad%a6kyung-min-choi%e6%95%99%e6%8e%88%e5%a6%82%e4%bd%95%e5%88%a9%e7%94%a8mofs%e6%8e%a7%e5%88%b6%e7%a5%9e%e7%bb%8f%e5%b9%b2","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=236344","title":{"rendered":"\u770b\u97e9\u56fd\u6dd1\u660e\u5973\u5b50\u5927\u5b66Kyung Min Choi\u6559\u6388\u5982\u4f55\u5229\u7528MOFs\u63a7\u5236\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u5206\u5316"},"content":{"rendered":"<p>\u4e00\u3001\u3010\u5bfc\u8bfb\u3011<\/p>\n<p>\u91d1\u5c5e-\u6709\u673a\u6846\u67b6\uff08MOFs\uff09\u662f\u4e00\u79cd\u7531\u91d1\u5c5e\u79bb\u5b50\u548c\u6709\u673a\u914d\u4f53\u6784\u6210\u7684\u5316\u5408\u7269\uff0c\u7531\u4e8e\u5176\u6676\u4f53\u7ed3\u6784\u7684\u663e\u8457\u5747\u5300\u6027\u548c\u5404\u79cd\u56e0\u7d20\u7684\u53ef\u53d8\u6027\uff0c\u5305\u62ec\u7ed3\u6784\u7c7b\u578b\u3001\u6709\u673a\u529f\u80fd\u6027\u3001\u51e0\u4f55\u5f62\u72b6\u3001\u542b\u91d1\u5c5e\u5355\u5143\u7684\u5927\u5c0f\u3001\u5b54\u7684\u5927\u5c0f\u548c\u7eb3\u7c73\u6676\u4f53\u7684\u5927\u5c0f\uff0c\u5df2\u6210\u4e3a\u4e00\u79cd\u5f88\u6709\u524d\u9014\u7684\u591a\u5b54\u6750\u6599\u3002MOFs\u7684\u8fd9\u4e9b\u4f18\u70b9\u5df2\u7ecf\u88ab\u5e94\u7528\u5230\u4e86\u5404\u4e2a\u9886\u57df\u4e2d\uff0c\u5305\u62ec\u9502\u79bb\u5b50\u7535\u6c60\u3001\u6c14\u4f53\u5206\u79bb\u3001\u6c14\u4f53\u50a8\u5b58\u548c\u50ac\u5316\u3002MOFs\u7684\u529f\u80fd\uff0c\u5c24\u5176\u662f\u5176\u51fa\u8272\u7684\u6355\u83b7\u548c\u91ca\u653e\u611f\u5174\u8da3\u7684\u5206\u5b50\uff0c\u5bf9\u751f\u7269\u5b66\u7814\u7a76\u6781\u4e3a\u6709\u5229\u3002\u5177\u4f53\u800c\u8a00\uff0c\u51e0\u79cd\u57fa\u672c\u7684\u751f\u7269\u5206\u5b50\uff0c\u5305\u62ec\u5927\u5757\u91d1\u5c5e\uff08\u5982\u94be\u3001\u9499\u548c\u9541\uff09\u3001\u5fae\u91cf\u91d1\u5c5e\uff08\u5982\u950c\u3001\u94c1\u548c\u9530\uff09\u3001\u6c28\u57fa\u9178\u3001\u795e\u7ecf\u9012\u8d28\uff0c\u751a\u81f3\u7ef4\u751f\u7d20\uff0c\u53ef\u4ee5\u5728MOFs\u4e2d\u957f\u671f\u50a8\u5b58\u548c\u4e0d\u65ad\u91ca\u653e\u3002\u56e0\u6b64\uff0c\u8fd9\u79cd\u5d4c\u5165\u751f\u7269\u5206\u5b50\u7684MOFs\u5bf9\u4e8e\u63a7\u5236\u5e72\u7ec6\u80de\u547d\u8fd0\u975e\u5e38\u6709\u7528\uff0c\u53ef\u4ee5\u90e8\u5206\u66ff\u4ee3\u4f53\u5185\u5468\u56f43D\u7ec6\u80de\u5fae\u73af\u5883\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u4e3a\u4e86\u5145\u5206\u53d1\u6325MOFs\u4f5c\u4e3a\u7a33\u5b9a\u5206\u5316\u56e0\u5b50\u4f9b\u5e94\u8005\u7684\u6f5c\u529b\uff0c\u5e94\u907f\u514d\u7ec6\u80de\u4e0eMOFs\u4e4b\u95f4\u7684\u7269\u7406\u63a5\u89e6\uff0c\u5305\u62ec\u5b83\u4eec\u88ab\u7ec6\u80de\u8d28\u5438\u6536\uff0c\u4ee5\u9632\u6b62MOFs\u7684\u7ed3\u6784\u53d8\u5f62\uff0c\u5e76\u907f\u514dMOFs\u5bf9\u9776\u7ec6\u80de\u7684\u6f5c\u5728\u7ec6\u80de\u6bd2\u6027\u6216\u4e0d\u5229\u5f71\u54cd\u3002<\/p>\n<p>\u4e8c\u3001\u3010\u6210\u679c\u63a0\u5f71\u3011<\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u97e9\u56fd\u4e2d\u592e\u5927\u5b66<\/strong><strong>Tae-Hyung Kim<\/strong><strong>\u6559\u6388\u548c\u97e9\u56fd\u6dd1\u660e\u5973\u5b50\u5927\u5b66<\/strong><strong>Kyung Min Choi<\/strong><strong>\u7b49\u4eba<\/strong>\u5408\u4f5c\uff0c\u4ee5\u201c<strong>Single metal-organic framework\u2013embedded nanopit arrays: A new way to control neural stem cell differentiation<\/strong>\u201d\u4e3a\u9898\u5728<strong>Science Advances<\/strong>\u671f\u520a\u4e0a\u53d1\u8868\u91cd\u8981\u7814\u7a76\u6210\u679c\u3002\u4f5c\u8005\u4f7f\u7528\u5355\u4e00\u91d1\u5c5e-\u6709\u673a\u6846\u67b6(MOF)\u7eb3\u7c73\u7c92\u5b50\u2014\u2014\u5d4c\u5165\u7eb3\u7c73\u9635\u5217(SMENA)\uff0c\u53ef\u4ee5\u9ad8\u6548\u5730\u751f\u6210\u795e\u7ecf\u5e72\u7ec6\u80de\u3002\u901a\u8fc7\u4f18\u5316\u5747\u5300\u5468\u671f\u6027\u7eb3\u7c73\u5f62\u6001\u7684\u7269\u7406\u53c2\u6570\uff0c\u6bcf\u4e2a\u7eb3\u7c73\u56fe\u53ef\u4ee5\u9650\u5236\u5355\u4e00\u7684nMOFs (UiO-67)\uff0c\u8fd9\u4e9bnMOFs\u662f\u4e13\u4e3a\u7ef4\u7532\u9178(RA)\u7684\u957f\u671f\u5b58\u50a8\u548c\u91ca\u653e\u800c\u8bbe\u8ba1\u7684\u3002SMENA\u65b9\u6cd5\u6210\u529f\u5730\u6291\u5236\u4e86\u4e0e\u7ec6\u80de\u7684\u7269\u7406\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u6709\u52a9\u4e8enMOF (RA\u2282UiO-67)\u7ed3\u6784\u7684\u663e\u8457\u7a33\u5b9a\u6027\uff0c\u800c\u4e0d\u8bf1\u5bfc\u7eb3\u7c73\u9897\u7c92\u4ecb\u5bfc\u7684\u6bd2\u6027\u95ee\u9898\u3002\u7531\u4e8eRA\u7684\u6301\u7eed\u548c\u957f\u671f\u4f9b\u5e94\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u5404\u79cd\u795e\u7ecf\u53d1\u751f\u76f8\u5173\u6d3b\u52a8\u7684mRNA\u8868\u8fbe\u589e\u5f3a\u3002\u4f5c\u8005\u5f00\u53d1\u7684SMENA\u65b9\u6cd5\u4e5f\u53ef\u4ee5\u5e94\u7528\u4e8e\u5176\u4ed6\u5e72\u7ec6\u80de\u6765\u6e90\u548c\u5206\u5316\u8c31\u7cfb\uff0c\u56e0\u6b64\u53ef\u7528\u4e8e\u5404\u79cd\u57fa\u4e8e\u5e72\u7ec6\u80de\u7684\u518d\u751f\u7597\u6cd5\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-236360 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/3-6.png\" alt=\"\" width=\"1349\" height=\"449\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/3-6.png 1349w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/3-6-300x100.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/3-6-768x256.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/3-6-1024x341.png 1024w\" sizes=\"(max-width: 1349px) 100vw, 1349px\" \/><\/p>\n<p>\u4e09\u3001\u3010\u56fe\u6587\u89e3\u6790\u3011<\/p>\n<p><strong>\u56fe<\/strong><strong>1.<\/strong> <strong>SMENA<\/strong><strong>\u539f\u7406\u56fe\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-236362 size-large\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/5-4-876x1024.png\" alt=\"\" width=\"876\" height=\"1024\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/5-4-876x1024.png 876w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/5-4-257x300.png 257w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/5-4-768x898.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/5-4.png 1488w\" sizes=\"(max-width: 876px) 100vw, 876px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>2.<\/strong> <strong>RA<\/strong><strong>\u2282<\/strong><strong>nUiO-67<\/strong><strong>\u7684\u5408\u6210\u4e0e\u8868\u5f81\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-236363 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/6-4.png\" alt=\"\" width=\"1964\" height=\"2197\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/6-4.png 1964w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/6-4-268x300.png 268w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/6-4-768x859.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/6-4-915x1024.png 915w\" sizes=\"(max-width: 1964px) 100vw, 1964px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>3.<\/strong> <strong>SMENA<\/strong><strong>\u7684\u8868\u5f81\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-236364 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/7-4.png\" alt=\"\" width=\"1504\" height=\"1860\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/7-4.png 1504w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/7-4-243x300.png 243w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/7-4-768x950.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/7-4-828x1024.png 828w\" sizes=\"(max-width: 1504px) 100vw, 1504px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>4.<\/strong> <strong>\u5728\u591a\u6b21\u4f20\u4ee3\u8fc7\u7a0b\u4e2d\u76d1\u6d4b\u5404\u7ec4\u57f9\u517b\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u591a\u80fd\u6027\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-236365 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/8-1.png\" alt=\"\" width=\"2160\" height=\"1956\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/8-1.png 2160w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/8-1-300x272.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/8-1-768x695.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/8-1-1024x927.png 1024w\" sizes=\"(max-width: 2160px) 100vw, 2160px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>5.<\/strong> <strong>\u4e0e\u795e\u7ecf\u53d1\u751f\u6709\u5173\u7684\u57fa\u56e0\u548c\u86cb\u767d\u8d28\u5206\u6790\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-236366 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/9-2.png\" alt=\"\" width=\"2160\" height=\"1774\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/9-2.png 2160w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/9-2-300x246.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/9-2-768x631.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/9-2-1024x841.png 1024w\" sizes=\"(max-width: 2160px) 100vw, 2160px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>6.<\/strong> <strong>NSCs<\/strong><strong>\u5206\u5316\u7ec6\u80de<\/strong><strong>mRNA<\/strong><strong>\u603b\u8868\u8fbe\u91cf\u5206\u6790\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-236367 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/10.png\" alt=\"\" width=\"2164\" height=\"945\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/10.png 2164w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/10-300x131.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/10-768x335.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2022\/04\/10-1024x447.png 1024w\" sizes=\"(max-width: 2164px) 100vw, 2164px\" \/><\/p>\n<p>\u56db\u3001\u3010\u6210\u679c\u542f\u793a\u3011<\/p>\n<p style=\"text-align: left;\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u5728\u4f53\u5916\u5f00\u53d1\u4e86\u7528\u4e8e\u63a7\u5236\u795e\u7ecf\u53d1\u751f\u7684SMENA\u3002nUiO-67\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u5728\u8f83\u77ed\u7684\u5b75\u80b2\u65f6\u95f4\uff08&lt;48\u5c0f\u65f6\uff09\u5185\u88c5\u8f7dRA\uff0c\u5e76\u4e14\u80fd\u591f\u5728\u8f83\u957f\u65f6\u95f4\uff08&gt;14\u5929\uff09\u5185\u91ca\u653eRA\u3002\u5c3d\u7ba1RA\u2282nUiO-67\u5728\u4f20\u7edf\u57f9\u517b\u6761\u4ef6\u4e0b\u4e0d\u7a33\u5b9a\uff0c\u4f46\u5728\u4fdd\u62a4RA\u514d\u53d7\u964d\u89e3\u548c\u5f02\u6784\u5316\u65b9\u9762\u4e5f\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u6027\u80fd\u3002\u90a3\u5747\u5300\u7684\u7eb3\u7c73\u7c92\u5b50\u9635\u5217\u5728\u6355\u83b7\u5355\u4e2aRA\u2282nUiO-67\u7c92\u5b50\u65b9\u9762\u6781\u4e3a\u6709\u6548\u3002\u7eb3\u7c73\u9897\u7c92\u4e2d\u7684RA\u2282nUiO-67\u7531\u4e8e\u9632\u6b62\u7ec6\u80de\u6444\u53d6\u800c\u5728\u957f\u65f6\u95f4\u57f9\u517b\u671f\u95f4\u4fdd\u6301\u7a33\u5b9a\uff0c\u53ef\u4ee5\u5728\u4e0d\u635f\u5bb3\u5176\u591a\u80fd\u6027\u7684\u60c5\u51b5\u4e0b\u63a7\u5236\u5c0f\u9f20NSCs\u7684\u795e\u7ecf\u53d1\u751f\u3002\u6210\u719f\u795e\u7ecf\u5143\u7684\u4ee3\u8868\u6807\u5fd7\u7269NeuroD1\u548cMAP2\u5728RA-SMENA\u4e0a\u7684\u8868\u8fbe\u6c34\u5e73\u5206\u522b\u6bd4\u5728\u5e38\u89c4\u5206\u5316\u57f9\u517b\u57fa\u7684\u7ec4\u7ec7\u57f9\u517b\u76bf\u4e0a\u5206\u5316\u7684\u7ec6\u80de\u9ad843.67\u548c41.3\u500d\u3002\u6b64\u5916\uff0c\u5927\u7ea61153\u4e2a\u4e0e\u795e\u7ecf\u53d1\u751f\u76f8\u5173\u7684\u57fa\u56e0\u5728RA-SMENA\u4e2d\u9009\u62e9\u6027\u4e0a\u8c03\uff0c\u6839\u636eKEGG\u901a\u8def\u5206\u6790\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u4e0eRA\u4ecb\u5bfc\u7684\u795e\u7ecf\u5143\u5206\u5316\u6709\u5173\u3002<\/p>\n<p>\u7531\u4e8eRA\u2282nUiO-67\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u901a\u8fc7\u63a7\u5236nMOF\u7684\u5b54\u9699\u5927\u5c0f\u3001\u5b54\u9699\u4f53\u79ef\u548c\u9897\u7c92\u5927\u5c0f\u6765\u91cd\u7ec4\u4ee5\u88c5\u8f7d\u4e0d\u540c\u7c7b\u578b\u7684\u751f\u7269\u5206\u5b50(\u4f8b\u5982\uff0c\u5496\u5561\u9178\u3001\u7c73\u8bfa\u5730\u5c14\u548c\u6297\u574f\u8840\u9178)\uff0c\u5f00\u53d1\u7684\u65b9\u6cd5\u6f5c\u529b\u975e\u5e38\u9ad8\u3002\u5177\u4f53\u5730\u8bf4\uff0c\u591a\u80fd\u5e72\u7ec6\u80de\u53ef\u4ee5\u4f7f\u7528\u591a\u5206\u5316\u56e0\u5b50\u8d1f\u8f7d\u7684SMENA\u65b9\u6cd5\u4ee5\u66f4\u9ad8\u6548\u3001\u66f4\u65b9\u4fbf\u7684\u65b9\u5f0f\u8f6c\u5316\u4e3a\u6240\u9700\u7684\u7ec6\u80de\u7c7b\u578b\u3002\u6b64\u5916\uff0c\u4f7f\u7528\u5148\u8fdb\u7684SMENA\u65b9\u6cd5\u53ef\u4ee5\u5b9e\u73b0\u6765\u81ea\u76f8\u540c\u5e72\u7ec6\u80de\u6e90\u81ea\u53d1\u7684\u591a\u7cfb\u5206\u5316\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u53ef\u4ee5\u5f97\u51fa\u7ed3\u8bba\uff0c\u5df2\u5f00\u53d1\u7684SMENA\u65b9\u6cd5\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u56e0\u6b64\u5728\u57fa\u4e8e\u5e72\u7ec6\u80de\u7684\u518d\u751f\u7597\u6cd5\u4e2d\u975e\u5e38\u6709\u524d\u666f\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5<\/strong>\uff1aSingle metal-organic framework\u2013embedded nanopit arrays: A new way to control neural stem cell differentiation. Science Advances, 2022, 8(16), eabj7736. 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