{"id":232811,"date":"2022-02-08T06:09:48","date_gmt":"2022-02-07T22:09:48","guid":{"rendered":"\/\/m.iemloyee.com\/?p=232811"},"modified":"2022-02-07T22:11:08","modified_gmt":"2022-02-07T14:11:08","slug":"%e9%9d%92%e5%b2%9b%e5%86%9c%e5%a4%a7%e7%8e%8b%e4%b8%bd%e4%b8%bd%ef%bc%86%e4%b8%ad%e7%a7%91%e9%99%a2%e5%ba%94%e5%8c%96%e6%89%80%e6%9e%97%e5%90%9bchemical-engineering-journal%ef%bc%9a%e7%ba%bf%e7%b2%92","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=232811","title":{"rendered":"\u738b\u4e3d\u4e3d\uff06\u6797\u541bChem. Eng. J.\uff1a\u7ebf\u7c92\u4f53\u9776\u5411\u7684\u9ed1\u8272\u7d20@mSiO2\u86cb\u9ec4\u58f3\u7ed3\u6784\u7528\u4e8e\u8fd1\u7ea2\u5916\u4e8c\u533a\u9a71\u52a8\u7684\u5149\u70ed-\u70ed\u52a8\u529b\/\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/b><\/strong><\/p>\n

\u57fa\u4e8e\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u7684\u5149\u70ed\u7597\u6cd5(PTT)\u7531\u4e8e\u5176\u65e0\u521b\u3001\u65e0\u6709\u5bb3\u526f\u4f5c\u7528\u3001\u9002\u7528\u6027\u5e7f\uff0c\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002\u4e0e\u4f20\u7edf\u7684NIR-\u00a0I\u5149\u5b66\u7a97\u53e3(650-950 nm)\u76f8\u6bd4\uff0c\u8fd1\u7ea2\u5916\u4e8c\u533a(NIR-\u2161)\u751f\u7269\u7a97\u53e3(1000-1700 nm)\u5141\u8bb8\u66f4\u6df1\u7684\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\uff0c\u66f4\u4f4e\u7684\u4fe1\u566a\u6bd4\uff0c\u66f4\u9ad8\u7684\u6700\u5927\u5141\u8bb8\u66dd\u5149\u3002\u5929\u7136\u9ed1\u8272\u7d20\u5728\u8fd1\u7ea2\u5916\u533a\u5177\u6709\u826f\u597d\u7684\u5438\u6536\u548c\u8f83\u9ad8\u7684\u5149\u70ed\u8f6c\u6362\u6548\u7387\uff0c\u5728\u751f\u7269\u533b\u5b66\u548c\u7eb3\u7c73\u6280\u672f\u9886\u57df\u663e\u793a\u51fa\u5f88\u5927\u7684\u524d\u666f\u3002\u7136\u800c\uff0c\u5149\u7ebf\u7a7f\u900f\u53d7\u9650\u53ef\u80fd\u5bfc\u81f4\u80bf\u7624\u6d88\u9664\u4e0d\u5b8c\u5168\uff0c\u7279\u522b\u662f\u6fc0\u5149\u7167\u5c04\u533a\u57df\u8fb9\u7f18\u6b8b\u7559\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u5bfc\u81f4\u80bf\u7624\u590d\u53d1\u5e76\u5411\u8fdc\u5904\u5668\u5b98\u8f6c\u79fb\u3002\u8fd1\u5e74\u6765\uff0c\u5305\u62ec\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u3001\u7ec6\u80de\u56e0\u5b50\u6cbb\u7597\u4ee5\u53ca\u5355\u514b\u9686\u6297\u4f53\u6cbb\u7597\u5728\u5185\u7684\u591a\u79cd\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u88ab\u7528\u4e8e\u63a2\u7d22\u6cbb\u7597\u764c\u8f6c\u79fb\u6027\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u764c\u75c7\u672c\u8eab\u5177\u6709\u514d\u75ab\u6291\u5236\u6027\uff0c\u5f88\u96be\u901a\u8fc7\u76ee\u524d\u7684\u514d\u75ab\u7597\u6cd5\u52a0\u4ee5\u63a7\u5236\u3002\u56e0\u6b64\uff0c\u7ed3\u5408\u5149\u70ed\u6cbb\u7597\u7b49\u5c40\u90e8\u7597\u6cd5\uff0c\u53ef\u4ee5\u5de7\u5999\u5730\u514b\u670d\u514d\u75ab\u7597\u6cd5\u7684\u5c40\u9650\u6027\uff0c\u6700\u5927\u9650\u5ea6\u5730\u53d1\u6325\u4e24\u79cd\u6cbb\u7597\u65b9\u5f0f\u7684\u4f18\u70b9\uff0c\u65e2\u80fd\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\uff0c\u5b9e\u73b0\u5bf9\u764c\u75c7\u7684\u957f\u671f\u514d\u75ab\uff0c\u589e\u52a0\u6574\u4f53\u6cbb\u7597\u7684\u9009\u62e9\u6027\u3002<\/p>\n

\u57fa\u4e8e\u4ee5\u4e0a\u7814\u7a76\u80cc\u666f\uff0c\u8fd1\u65e5\uff0c\u9752\u5c9b\u519c\u4e1a\u5927\u5b66\u738b\u4e3d\u4e3d\u6559\u6388\u548c\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u5316\u6240\u6797\u541b\u6559\u6388\u56e2\u961f\u901a\u8fc7\u5dee\u901f\u79bb\u5fc3\u6cd5\u63d0\u53d6\u5747\u5300\u7684\u58a8\u9c7c\u56ca\u9ed1\u8272\u7d20\uff0c\u5728\u6b63\u7845\u9178\u56db\u4e59\u916f(TEOS)\u548c\u5341\u516d\u70f7\u57fa\u4e09\u7532\u57fa\u6c2f\u5316\u94f5(CTAC)\u5b58\u5728\u4e0b\uff0c\u4ee5\u5747\u4e09\u7532\u82ef\u4f5c\u4e3a\u6269\u5b54\u5242\uff0c\u4ece\u800c\u5408\u6210\u4e86mSiO2<\/sub>\u5305\u8986\u9ed1\u8272\u7d20\u7684\u86cb\u9ec4\u58f3\u7eb3\u7c73\u7ed3\u6784(MS)\uff1b\u5e76\u5728SiO2<\/sub>\u58f3\u5c42\u63a5\u679d\u4e0a-NH2<\/sub>\u540e\uff0c(3-\u7fa7\u57fa\u4e19\u57fa)\u4e09\u82ef\u57fa\u6eb4\u5316\u78f7(CTPP)\u4e0e-NH2<\/sub>\u5171\u4ef7\u952e\u5408\uff0c\u5f97\u5230CTPP\u6539\u6027\u7684\u7eb3\u7c73\u9897\u7c92\uff1b\u6700\u540e\uff0c\u5c06AIPH\u52a0\u8f7d\u5230MS-CTPP\u7684\u5927\u4ecb\u5b54\u4e2d\uff0c\u6784\u5efaAIPH@MS-CTPP\u7eb3\u7c73\u7ed3\u6784 (\u56fe1)\u3002<\/p>\n

\u8be5\u5e73\u53f0\u5177\u6709\u4ee5\u4e0b\u4f18\u70b9\uff1a1)\u00a0SiO2<\/sub>\u548c\u5929\u7136\u9ed1\u8272\u7d20\u7eb3\u7c73\u9897\u7c92\u5747\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u751f\u7269\u5b89\u5168\u6027\uff1b2)\u00a0SiO2<\/sub>\u58f3\u5185\u63a5\u679d\u7684(3-\u7fa7\u57fa\u4e19\u57fa)\u4e09\u82ef\u57fa\u6eb4\u5316\u81a6(CTPP)\u8d4b\u4e88MS\u7ebf\u7c92\u4f53\u9776\u5411\u6027\uff1b3)\u00a0\u5927\u4ecb\u5b54\u53ef\u663e\u8457\u589e\u52a0AIPH\u7684\u8d1f\u8377\u91cf\uff0c\u8fdb\u800c\u4fc3\u8fdb\u70f7\u57fa\u81ea\u7531\u57fa\u7684\u751f\u6210\uff0c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff1b4)\u00a0NIR-\u2161\u4ecb\u5bfc\u7684PTT\u548cTDT\u5177\u6709\u8f83\u9ad8\u7684\u6700\u5927\u5141\u8bb8\u8f90\u7167\u548c\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\uff1b5)\u00a0\u5929\u7136\u9ed1\u8272\u7d20\u7eb3\u7c73\u9897\u7c92\u80fd\u4f7fM2 \u8868\u578b\u5de8\u566c\u7ec6\u80de\u590d\u6781\u5316\u6210\u6297\u80bf\u7624M1\u8868\u578b\uff0c\u8bf1\u5bfcPTT\u548c\u4e8c\u6c27\u5316\u7845\u53cc\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff1b6)\u57281064 nm\u8fd1\u7ea2\u5916\u4e8c\u533a\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u901a\u8fc7\u9ed1\u8272\u7d20\u7684\u5149\u70ed\u8f6c\u5316\uff0c\u5b9e\u73b0\u4e86\u5149\u70ed\u6cbb\u7597\u548c\u70ed\u52a8\u529b\u6cbb\u7597\u7684\u534f\u540c\u6cbb\u7597\uff0c\u4e5f\u5b9e\u73b0\u4e86\u5149\u70ed\u6cbb\u7597\u548c\u4e8c\u6c27\u5316\u7845\u4ecb\u5bfc\u7684\u514d\u75ab\u589e\u5f3a\u4f5c\u7528\u3002<\/p>\n

\u8be5\u6210\u679c\u4ee5\u201cMitochondrial Targeted Melanin@mSiO2<\/sub>\u00a0Yolk-shell Nanostructures for NIR-\u2161-driven Photo-Thermal-Dynamic\/Immunotherapy\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u4e8e\u56fd\u9645\u9876\u7ea7\u671f\u520a\u300aChemical Engineering Journal\u300b(\u6587\u7ae0DOI\uff1a10.1016\/j.cej.2022.134869)\u3002\u9752\u5c9b\u519c\u4e1a\u5927\u5b66\u4e3a\u8be5\u8bba\u6587\u7b2c\u4e00\u5b8c\u6210\u5355\u4f4d\uff0c\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u5316\u6240\u3001\u5c71\u4e1c\u5927\u5b66\u548c\u5c71\u4e1c\u7b2c\u4e00\u533b\u79d1\u5927\u5b66\u9752\u5c9b\u9644\u5c5e\u533b\u9662\u4e3a\u5408\u4f5c\u5355\u4f4d\u3002\u5f20\u5b87\u540c\u5b66\u548c\u738b\u7426\u540c\u5b66\u4e3a\u8be5\u8bba\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u738b\u4e3d\u4e3d\u6559\u6388\u3001\u6797\u541b\u6559\u6388\u3001\u4e01\u5f6c\u5f6c\u7279\u522b\u7814\u7a76\u52a9\u7406\u4e3a\u5171\u540c\u901a\u8baf\uff0c\u7eaa\u5955\u987a\u4e3b\u6cbb\u533b\u5e08\u548c\u8303\u4e3d\u5a9b\u535a\u58eb\u4e3a\u8bba\u6587\u7684\u5408\u4f5c\u8005\u3002\u8be5\u9879\u7814\u7a76\u5de5\u4f5c\u83b7\u5f97\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u4e2d\u6fb3\u653f\u5e9c\u79d1\u6280\u5408\u4f5c\u9879\u76ee\u3001\u535a\u58eb\u540e\u521b\u65b0\u4eba\u624d\u652f\u6301\u8ba1\u5212\u4ee5\u53ca\u9752\u5c9b\u519c\u4e1a\u5927\u5b66\u9ad8\u5c42\u6b21\u4eba\u624d\u57fa\u91d1\u7b49\u9879\u76ee\u7684\u8d44\u52a9\u3002<\/p>\n

\u3010\u56fe\u6587\u8be6\u60c5\u3011<\/b><\/strong><\/p>\n

\u793a\u610f\u56fe1\uff1a<\/b><\/strong>AIPH@MS-CTPP\u53ca\u5176\u534f\u540cPTT\u3001TDT\u548c\u514d\u75ab\u7597\u6cd5\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u56fe1<\/b><\/strong>\u00a0AIPH@MS-CTPP<\/b><\/strong>\u7eb3\u7c73\u9897\u7c92\u7684\u8868\u5f81<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a-d) \u9ed1\u8272\u7d20\u3001MS\u3001MS-CTPP\u548cAIPH@MS-CTPP\u7684TEM\u56fe\u50cf<\/p>\n

e-h) \u9ed1\u8272\u7d20\u3001MS\u3001MS-CTPP\u548cAIPH@MS-CTPP\u7684SEM\u56fe\u50cf<\/p>\n

i-l) AIPH@MS-CTPP\u4e2dC\u3001N\u3001Si\u3001O\u3001Cl\u548cP\u7684\u5143\u7d20\u6620\u5c04\u56fe\u3001HADDF-STEM\u56fe\u3001\u7ebf\u626b\u63cf\u8f6e\u5ed3\u548cXPS\u5149\u8c31<\/p>\n

m) \u9ed1\u8272\u7d20\u548cMS\u7684\u6c2e\u6c14\u5438\u9644-\u89e3\u5438\u7b49\u6e29\u7ebf<\/p>\n

n) \u9ed1\u8272\u7d20\u3001MS\u548cAIPH@MS-CTPP\u7684DLS\u5206\u5e03\u56fe<\/p>\n

o) \u9ed1\u8272\u7d20\u3001MS\u3001MS-NH2<\/sub>\u548cAIPH@MS-CTPP\u7eb3\u7c73\u9897\u7c92\u7684Zeta\u7535\u4f4d<\/p>\n

\u56fe2<\/b><\/strong>\u00a0AIPH@MS<\/b><\/strong>–<\/b><\/strong>CTPP<\/b><\/strong>\u7684X<\/b><\/strong>PS<\/b><\/strong>\u548c\u5149\u70ed\u8f6c\u6362\u6027\u80fd\u8868\u5f81<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a-f)\u00a0AIPH@MS-CTPP\u4e2dSi 2p, O 1s, C 1s, N 1s, Cl 2p, P 2p\u7684XPS\u8c31<\/p>\n

g) MS\u6c34\u6eb6\u6db2(1 mg\u00b7ml-1<\/sup>)\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31<\/p>\n

h) \u9ed1\u8272\u7d20\u548cMS (1 mg\u00b7ml-1<\/sup>)\u7684\u6e29\u5ea6\u66f2\u7ebf<\/p>\n

i)\u4e0d\u540c\u6d53\u5ea6\u7684MS\u57281064 nm\u6fc0\u5149\u7167\u5c04\u4e0b\u7684\u6e29\u5ea6\u66f2\u7ebf<\/p>\n

j,\u00a0k) MS\u968f\u8f90\u7167\u6e29\u5ea6\u53d8\u53168min\uff0c\u7136\u540e\u5173\u95ed\u6fc0\u5149\u7684\u6e29\u5ea6\u53d8\u5316\u66f2\u7ebf\u4ee5\u53ca\u51b7\u5374\u65f6\u95f4\u4e0e\u8d1f\u81ea\u7136\u5bf9\u6570\u7684\u5173\u7cfb\u56fe<\/p>\n

l) MS\u7eb3\u7c73\u9897\u7c92\u7684\u5faa\u73af\u52a0\u70ed\u66f2\u7ebf<\/p>\n

\u4ee5\u4e0a\u6240\u7528\u6fc0\u5149\u8f90\u7167\u529f\u7387\u5747\u4e3a1.0 W\u00b7cm-2<\/sup><\/p>\n

\u56fe3<\/b><\/strong>\u00a0<\/b><\/strong>\u4f53\u5916\u8054\u5408\u6cbb\u7597\u6548\u679c<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a) PTT\/TDT\u6d41\u7a0b\u793a\u610f\u56fe(AIPH@MS-CTPP)<\/p>\n

b, c) AIPH@MS-CTPP\u6eb6\u6db2\u4e2dPOBN\u7684ESR\u5149\u8c31\u4ee5\u53caESR\u5cf0\u503c\u968f\u8f90\u7167\u65f6\u95f4\u7684\u53d8\u5316\u66f2\u7ebf<\/p>\n

d) CLSM\u56fe\u50cf\u663e\u793aAIPH@MS\/Ce6\u548cAIPH@MS-CTPP\/Ce6\u5b75\u80b24 h\u540e\u7684\u4e9a\u7ec6\u80de\u5b9a\u4f4d<\/p>\n

e)\u4e0d\u540c\u6d53\u5ea6\u7684\u9ed1\u8272\u7d20\u3001MS\u3001MS-CTPP\u548cAIPH@MS-CTPP\u5728\u9ed1\u6697\u6761\u4ef6\u4e0b\u5904\u74064T1\u7ec6\u80de\u7684\u76f8\u5bf9\u5b58\u6d3b\u7387<\/p>\n

f)\u4e0d\u540c\u6d53\u5ea6\u7684\u9ed1\u8272\u7d20\u3001MS\u3001MS- CTPP\u6216AIPH@MS-CTPP\u5904\u740612 h\u540e\uff0c1064 nm\u6fc0\u5149\u7167\u5c044T1\u7ec6\u80de\u7684\u76f8\u5bf9\u5b58\u6d3b\u7387<\/p>\n

g)\u4e0d\u540c\u5206\u7ec44T1\u7ec6\u80de\u81ea\u7531\u57fa\u68c0\u6d4b(\u6807\u5c3a\u4e3a250 \u03bcm)<\/p>\n

h)\u4e0d\u540c\u7ec4calcein AM(\u7eff\u8272)\u548cPI(\u7ea2\u8272)\u67d3\u8272\u76844T1\u7ec6\u80de\u7684CLSM\u6210\u50cf<\/p>\n

i)\u4e0d\u540c\u5904\u7406\u76844T1\u7ec6\u80de\u51cb\u4ea1\u68c0\u6d4b<\/p>\n

\u4ee5\u4e0a\u4f7f\u7528\u7167\u5c04\u6fc0\u5149:1064 nm, 1.0 W\u00b7cm– 2<\/sup>, 5 min<\/p>\n

\u56fe4<\/b><\/strong>\u00a0<\/b><\/strong>\u4e0d\u540c\u7eb3\u7c73\u9897\u7c92\u7684\u4f53\u5185\u6cbb\u7597\u8bc4\u4ef7<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a) \u4f53\u5185\u5b9e\u9a8c\u7684\u5904\u7406\u8fc7\u7a0b<\/p>\n

b)1064 nm\u6fc0\u5149\u7167\u5c04\u8377\u7624\u5c0f\u9f20\u7684\u8fd1\u7ea2\u5916\u70ed\u50cf\u56fe<\/p>\n

c)\u6cbb\u7597\u8fc7\u7a0b\u4e2d4T1\u8377\u7624\u5c0f\u9f20\u7684\u7167\u7247<\/p>\n

d, e)\u7b2c9\u5929\u4e0d\u540c\u6cbb\u7597\u540e\u7684\u539f\u53d1\u548c\u8fdc\u7aef\u80bf\u7624\u7684\u7535\u5b50\u7167\u7247<\/p>\n

f, g) \u6cbb\u7597\u540e\u5c0f\u9f20\u539f\u53d1\u548c\u8fdc\u7aef\u80bf\u7624\u91cd\u91cf<\/p>\n

h, i)\u5404\u7ec4\u5c0f\u9f20\u7b2c9\u5929\u7684\u539f\u53d1\u80bf\u7624\u548c\u8fdc\u7aef\u80bf\u7624\u76f8\u5bf9\u4f53\u79ef\u66f2\u7ebf<\/p>\n

j, k) Western blot\u548cCaspase-3\u5728\u539f\u53d1\u548c\u8fdc\u7aef\u80bf\u7624\u4e2d\u4e0d\u540c\u5904\u7406\u7684\u76f8\u5bf9\u86cb\u767d\u8868\u8fbe<\/p>\n

l, m)\u539f\u53d1\u548c\u8fdc\u7aef\u80bf\u7624\u5207\u7247H&E\u548cTUNEL\u67d3\u8272\u56fe\u50cf\uff1b\u6bd4\u4f8b\u5c3a= 50 \u03bcm<\/p>\n

\u4ee5\u4e0a\u5206\u7ec4\u4e3a \u2160: PBS + \u03b1-PD-1 +\u6fc0\u5149\u3001\u2161:\u9ed1\u8272\u7d20+\u6fc0\u5149\u3001\u2162:MS +\u6fc0\u5149\u3001\u2163:AIPH@MS +\u6fc0\u5149\u3001\u2164:AIPH@MS-CTPP +\u6fc0\u5149\u3001\u2165:AIPH@MS-CTPP + \u03b1-PD-1 +\u6fc0\u5149\u3002(1064 nm\u6fc0\u5149\uff0c1.0 W\u00b7cm-2<\/sup>)\u00a0<\/p>\n

\u56fe5 \u5c0f\u9f20\u4f53\u5185\u514d\u75ab\u6cbb\u7597<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a-c) ELISA\u68c0\u6d4bTNF-\u03b1\uff0cb) IFN-\u03b3\uff0cc) IL-12\u86cb\u767d\u7684\u542b\u91cf<\/p>\n

d) \u4e0d\u540c\u6cbb\u7597\u540e\u8fdc\u7aef\u80bf\u7624\u4e2dCD4+<\/sup>\u3001CD8+<\/sup>T\u7ec6\u80de\u6d78\u6da6\u53caFoxp-3 Treg\u7ec6\u80de\u3001CD86\u3001CD206\u7684\u4ee3\u8868\u6027\u514d\u75ab\u8367\u5149\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a:50 \u03bcm<\/p>\n

\u4ee5\u4e0a\u5206\u7ec4\u4e3a\uff1a\u2160: PBS + \u03b1-PD-1 +\u6fc0\u5149\u3001\u2161: \u9ed1\u8272\u7d20+\u6fc0\u5149\u3001\u2162: MS +\u6fc0\u5149\u3001\u2163: AIPH@MS +\u6fc0\u5149\u3001\u2164: AIPH@MS-CTPP +\u6fc0\u5149\u3001\u2165: AIPH@MS-CTPP + \u03b1-PD-1 +\u6fc0\u5149\u3002(1064 nm\u6fc0\u5149\uff0c1.0 W\u00b7cm-2<\/sup>)<\/p>\n

\u56fe6 \u5c0f\u9f20\u6b63\u5e38\u5668\u5b98\u7684H\uff06E\u67d3\u8272<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u8377\u76244T1\u5c0f\u9f20\u4e0d\u540c\u5904\u7406\u540e\u810f\u5668\u7ec4\u7ec7(\u5fc3\u3001\u809d\u3001\u813e\u3001\u80ba\u3001\u80be)\u7684H&E\u67d3\u8272(\u6807\u5c3a:50 \u03bcm)\u3002<\/p>\n

\u4ee5\u4e0a\u5206\u7ec4\u4e3a \u2160: PBS + \u03b1-PD-1 +\u6fc0\u5149\u3001\u2161: \u9ed1\u8272\u7d20+\u6fc0\u5149\u3001\u2162: MS +\u6fc0\u5149\u3001\u2163: AIPH@MS +\u6fc0\u5149\u3001\u2164: AIPH@MS-CTPP +\u6fc0\u5149\u3001\u2165: AIPH@MS-CTPP + \u03b1-PD-1 +\u6fc0\u5149\u00a0(1064 nm\u6fc0\u5149\uff0c1.0 W\u00b7cm-2<\/sup>)<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/b><\/strong><\/p>\n

\u672c\u6587\u901a\u8fc7\u63d0\u53d6\u76f4\u5f84\u4e3a100 nm\u5de6\u53f3\u7684\u5929\u7136\u58a8\u9c7c\u56ca\u9ed1\u8272\u7d20\uff0c\u540e\u7528\u5927\u4ecb\u5b54SiO2<\/sub>\u5305\u88ab\uff0cCTPP\u4fee\u9970\u540e\u8d1f\u8f7dAIPH\uff0c\u5f62\u6210\u4e86AIPH@MS-CTPP\u7eb3\u7c73\u9897\u7c92\u3002\u57281064 nm\u7684\u6fc0\u5149\u7167\u5c04\u4e0b\uff0cAIPH@MS-CTPP\u7eb3\u7c73\u9897\u7c92\u8868\u73b0\u51fa\u51fa\u8272\u7684\u5149\u70ed\u6027\u8d28\uff0c\u4ea7\u751f\u70ed\u91cf\u4f7fAIPH\u70ed\u5206\u89e3\u4ea7\u751f\u70f7\u57fa\u81ea\u7531\u57fa\uff0c\u7528\u4e8e\u539f\u4f4d\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u3002\u5c06PTT\u3001TDT\u4e0e\u03b1-PD-1\u6cbb\u7597\u7b49\u591a\u79cd\u6cbb\u7597\u624b\u6bb5\u8054\u5408\uff0c\u901a\u8fc7\u4f53\u5916\u6fc0\u5149\u7167\u5c04\uff0c\u4f53\u5185\u6ce8\u5c04\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u7684\u65b9\u5f0f\uff0c\u6765\u8fbe\u5230\u6740\u706d\u539f\u4f4d\u80bf\u7624\uff0c\u6291\u5236\u8fdc\u7aef\u80bf\u7624\u7684\u76ee\u7684\u3002\u6b64\u5916\uff0c\u57fa\u4e8e\u5929\u7136\u9ed1\u8272\u7d20\u548c\u4ecb\u5b54SiO2<\/sub>\u90fd\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u5b89\u5168\u6027\uff0c\u56e0\u6b64\u6211\u4eec\u5f97\u5230\u7684AIPH-MS@CTPP\u7eb3\u7c73\u9897\u7c92\u5177\u6709\u5f88\u597d\u7684\u4e34\u5e8a\u6cbb\u7597\u524d\u666f\u3002<\/p>\n

\u5176\u4ed6\u76f8\u5173\u5de5\u4f5c<\/p>\n

(1) NIR-Driven Water Splitting H2<\/sub>\u00a0Production Nanoplatform for H2<\/sub>-Mediated Cascade-Amplifying Synergetic Cancer Therapy \u00a0(ACS Appl. Mater. Interfaces 2020, 12, 23677-23688, DOI: 10.1021\/acsami.0c03852)<\/p>\n

(2) A Three-in-one ZIFs-Derived CuCo(O)\/GOx@PCNs Hybrid Cascade\u00a0Nanozyme for Immunotherapy\/Enhanced Starvation\/Photothermal\u00a0Therapy (ACS Appl. Mater. Interfaces, 2021, 10.1021\/acsami.1c01006)<\/p>\n

(3) A multimodal strategy of Fe3<\/sub>O4<\/sub>@ZIF-8\/GOx@MnO2<\/sub>\u00a0hybrid nanozyme via TME modulation for tumor\u00a0therapy (Nanoscale, 2021, DOI: 10.1039\/d1nr04196g)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u57fa\u4e8e\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u7684\u5149\u70ed\u7597\u6cd5(PTT)\u7531\u4e8e\u5176\u65e0\u521b\u3001\u65e0\u6709\u5bb3\u526f\u4f5c\u7528\u3001\u9002\u7528\u6027\u5e7f\uff0c\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002\u4e0e\u4f20\u7edf\u7684NIR-\u00a0I\u5149\u5b66\u7a97\u53e3(650-950…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-232811","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/232811"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=232811"}],"version-history":[{"count":6,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/232811\/revisions"}],"predecessor-version":[{"id":232846,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/232811\/revisions\/232846"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=232811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=232811"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=232811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}