{"id":229784,"date":"2021-11-18T06:28:06","date_gmt":"2021-11-17T22:28:06","guid":{"rendered":"\/\/m.iemloyee.com\/?p=229784"},"modified":"2021-11-17T21:28:29","modified_gmt":"2021-11-17T13:28:29","slug":"%e6%ad%a6%e6%b1%89%e5%a4%a7%e5%ad%a6%e5%bc%a0%e5%85%88%e6%ad%a3%e5%9b%a2%e9%98%9f%ef%bc%9a%e5%90%ab%e9%93%b6%e6%b0%b4%e5%87%9d%e8%83%b6%e8%b0%83%e6%8e%a7%e5%8f%a3%e8%85%94%e8%8f%8c%e7%be%a4%e5%8d%8f","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=229784","title":{"rendered":"\u6b66\u6c49\u5927\u5b66\u5f20\u5148\u6b63\u56e2\u961f\uff1a\u542b\u94f6\u6c34\u51dd\u80f6\u8c03\u63a7\u53e3\u8154\u83cc\u7fa4\u534f\u52a9\u6297\u764c\uff01"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u514d\u75ab\u6cbb\u7597\u901a\u8fc7\u5f15\u53d1\u5f3a\u70c8\u7684\u514d\u75ab\u53cd\u5e94\u6765\u5bf9\u6297\u5404\u79cd\u764c\u75c7\u3002\u800c\u5728\u4f17\u591a\u764c\u75c7\u4e2d\uff0c\u53e3\u8154\u9cde\u72b6\u7ec6\u80de\u764c(OSCC) \u76845\u5e74\u751f\u5b58\u7387\u4ecd\u7136\u4fdd\u6301\u572850%\u5de6\u53f3\u3002\u7531\u4e8eOSCC\u6297\u539f\u8f7d\u91cf\u9ad8\uff0c\u514d\u75ab\u6cbb\u7597\u6709\u671b\u76f8\u5f53\u7a0b\u5ea6\u4e0a\u5730\u63d0\u5347\u6cbb\u7597\u6548\u679c\u3002\u7136\u800c\uff0cOSCC\u5bf9\u6d3e\u59c6\u5355\u6297\u514d\u75ab\u6cbb\u7597\u7684\u5e94\u7b54\u7387\u4ec5\u4e3a14.6%\uff0c\u51f8\u663e\u51fa\u5236\u5b9a\u65b0\u578b\u7b56\u7565\u6765\u8bf1\u5bfcOSCC\u4e2d\u66f4\u6709\u6548\u514d\u75ab\u5e94\u7b54\u7684\u8feb\u5207\u9700\u8981\u3002\u6700\u8fd1\uff0c\u4e00\u4e9b\u7814\u7a76\u62a5\u9053\u4e86\u5171\u751f\u7ec6\u83cc\u7684\u8c03\u8282\u4e0e\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u7684\u54cd\u5e94\u6027\u4e4b\u95f4\u7684\u8054\u7cfb\uff0c\u8868\u660e\u8c03\u8282\u53e3\u8154\u83cc\u7fa4\u53ef\u6539\u5584\u53e3\u8154\u9cde\u764c\u7684\u514d\u75ab\u5e94\u7b54\u3002\u7136\u800c\uff0c\u5173\u4e8e\u53e3\u8154\u9cde\u764c\u3001\u53e3\u8154\u5fae\u751f\u7269\u7fa4\u4e0e\u514d\u75ab\u7cfb\u7edf\u5173\u7cfb\u7684\u7814\u7a76\u76ee\u524d\u6765\u8bf4\u8fd8\u4e0d\u591a\u89c1\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u671f\uff0c\u6b66\u6c49\u5927\u5b66\u7684\u5f20\u5148\u6b63\u6559\u6388\u548c\u5b59\u5fd7\u519b\u6559\u6388<\/strong>\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u53d1\u73b0\u5728\u53e3\u8154\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u7684\u80bf\u7624\u4e2d\uff0c\u8f83\u9ad8\u6c34\u5e73\u7684\u6d88\u5316\u94fe\u7403\u83cc\u5c5e\u7ec6\u83cc\u80fd\u591f\u5927\u6982\u7387\u5730\u8fdb\u884c\u957f\u671f\u751f\u5b58\u3002\u57fa\u4e8e\u8fd9\u4e00\u73b0\u8c61\uff0c\u4f5c\u8005\u5728\u5c0f\u9f20OSCC\u80bf\u7624\u4e2d\u6ce8\u5165OSCC\u60a3\u8005\u7684\u53e3\u8154\u5fae\u751f\u7269\u7fa4\uff0c\u8fdb\u4e00\u6b65\u57fa\u4e8e\u6d88\u5316\u94fe\u7403\u83cc\u7684\u4ee3\u8c22\u7279\u5f81\uff0c\u8bbe\u8ba1\u4e86\u542b\u94f6\u7eb3\u7c73\u7c92\u5b50\u9ecf\u819c\u7c98\u9644\u6027\u6c34\u51dd\u80f6\u5bf9\u53e3\u8154\u4e2d\u5176\u4ed6\u7ec6\u83cc\u7684\u751f\u957f\u8fdb\u884c\u6291\u5236\uff0c\u800c\u4e0d\u5f71\u54cd\u6d88\u5316\u94fe\u7403\u83cc\u7684\u589e\u6b96\u3002\u56e0\u6b64\u4f7f\u5f97\u6291\u764c\u7684\u6d88\u5316\u94fe\u7403\u83cc\u5728\u53e3\u8154\u83cc\u7fa4\u4e2d\u5360\u636e\u4e86\u4f18\u52bf\u5730\u4f4d\u3002\u8fd9\u4e00\u7814\u7a76\u8868\u660e\uff0c\u7406\u6027\u8bbe\u8ba1\u7684\u751f\u7269\u6750\u6599\u53ef\u4ee5\u7279\u5f02\u6027\u7684\u8c03\u8282\u4eba\u7c7b\u5fae\u751f\u7269\u7fa4\uff0c\u4ee5\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u672c\u6587\u7b2c\u4e00\u4f5c\u8005\u4e3a\u90d1\u8fea\u5a01\u548c\u9093\u4f1f\u4f1f<\/strong>\uff0c\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cBiomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aNature Biomedical Engineering<\/strong>\u4e0a\u3002<\/p>\n

\"\"<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

\u56fe\u4e00\u3001<\/strong>OSCC<\/strong>\u76f8\u5173\u7ec6\u83cc\u7684\u7b5b\u9009<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09OSCC\u60a3\u8005\u764c\u7ec4\u7ec7\u548c\u764c\u65c1\u7ec4\u7ec7\u4e2d\u68c0\u6d4b\u5230\u7684\u7ec6\u83cc\u79cd\u7c7b\u7684\u7ef4\u6069\u56fe\u548cPcoA\u5206\u6790(P = 0.148)\uff1b<\/p>\n

\uff08b\uff09OSCC\u539f\u53d1\u80bf\u7624\u548c\u764c\u65c1\u7ec4\u7ec7\u7684\u5c5e\u6c34\u5e73\u76f8\u5bf9\u5fae\u751f\u7269\u4e30\u5ea6\uff1b<\/p>\n

\uff08c\uff099\u4f8b\u60a3\u8005\u7684OSCC\u80bf\u7624\u548c\u764c\u65c1\u7ec4\u7ec7\u7684\u6d88\u5316\u94fe\u7403\u83cc\u542b\u91cf\u68c0\u6d4b\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08d\uff09\u5f2f\u66f2\u6746\u83cc\u5c5e\u548c\u535f\u5549\u5355\u80de\u83cc\u5c5e\u7684\u8ba1\u6570\uff1b<\/p>\n

\uff08e\uff09\u6d88\u5316\u94fe\u7403\u83cc\u5c5e\u5728\u80bf\u7624(n = 199)\u3001\u764c\u524d\u75c5\u53d8(n = 63)\u548c\u7c98\u819c\u7ec4\u7ec7(n = 30)\u4e2d\u7684\u6570\u91cf\u00a0 \uff1b<\/p>\n

\uff08f\uff09\u6839\u636e\u80bf\u7624\u5185\u6d88\u5316\u94fe\u7403\u83cc\u591a\u5c11\u533a\u5206\u7684OSCC\u60a3\u8005\u751f\u5b58\u66f2\u7ebf\u3002<\/p>\n

\u56fe\u4e8c\u3001<\/strong>\u6d88\u5316\u94fe\u7403\u83cc<\/strong>\u6d3b\u5316\u6297\u764c\u514d\u75ab\u53cd\u5e94\u7684\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u6811\u7a81\u7ec6\u80de\u6210\u719f\u7684\u6d41\u5f0f\u5206\u6790\uff1b<\/p>\n

\uff08b\uff09\u60a3\u8005\u7624\u5185CD8\u6c34\u5e73\u4e0e\u6d88\u5316\u94fe\u7403\u83cc\u6c34\u5e73\u7684\u7ebf\u6027\u56de\u5f52\u5206\u6790\uff1b<\/p>\n

\uff08c\uff09\u80bf\u7624\u6d78\u6da6\u6027\u514d\u75ab\u7ec6\u80de\u4ee5\u53ca\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u6c34\u5e73\u7684\u6d41\u5f0f\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

\uff08d\uff09\u5dee\u5f02\u57fa\u56e0\u7684KEGG\u5bcc\u96c6\u5206\u6790\uff1b<\/p>\n

\uff08e-f\uff09Toll\u6837\u53d7\u4f53\u4fe1\u53f7\u4f20\u9012\uff08e\uff09\u548cNOD\u6837\u53d7\u4f53\u4fe1\u53f7\u4f20\u9012\uff08f\uff09\u7684\u5dee\u5f02\u57fa\u56e0\u76f4\u65b9\u56fe\uff1b<\/p>\n

\uff08g\uff09HEK293\u7684\u751f\u7269\u53d1\u5149\u5f3a\u5ea6;<\/p>\n

\uff08h\uff09NOD\u6837\u53d7\u4f53\u3001TLR4\u4ee5\u53caTLR7\/9\u53d7\u4f53\u7684\u6291\u5236\u5242\u5728P. anaerobius-<\/em>\u4ecb\u5bfc\u7684\u6811\u7a81\u7ec6\u80de\u6d3b\u5316\u4e0a\u7684\u4f5c\u7528\u3002<\/p>\n

\u56fe\u4e09\u3001<\/strong>\u542b\u94f6\u6c34\u51dd\u80f6\uff08<\/strong>Agel<\/strong>\uff09\u4e3a\u6d88\u5316\u94fe\u7403\u83cc\u63d0\u4f9b\u9009\u62e9\u6027\u751f\u957f\u4f18\u52bf\u7684\u80fd\u529b<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u94f6\u7eb3\u7c73\u9897\u7c92\u3001\u91d1\u7eb3\u7c73\u9897\u7c92\u3001\u56db\u6c27\u5316\u4e09\u94c1\u7eb3\u7c73\u9897\u7c92\u3001\u6c2e\u5316\u78b3\u7eb3\u7c73\u7247\u3001\u7ea4\u7ef4\u7d20\u7eb3\u7c73\u6676\u3001\u77f3\u58a8\u70ef\u7eb3\u7c73\u7247\u3001\u6c27\u5316\u950c\u7eb3\u7c73\u9897\u7c92\u3001\u58f3\u805a\u7cd6\u7eb3\u7c73\u9897\u7c92\u3001\u4e8c\u6c27\u5316\u949b\u7eb3\u7c73\u9897\u7c92\u3001\u6c27\u5316\u94c8\u7eb3\u7c73\u9897\u7c92\u3001\u6c27\u5316\u9521\u7eb3\u7c73\u9897\u7c92\u4ee5\u53ca\u6c27\u5316\u94dc\u7eb3\u7c73\u9897\u7c92\u5bf9\u7ec6\u83cc\u751f\u957f\u4f5c\u7528\u7684\u7b5b\u9009\uff1b<\/p>\n

\uff08b\uff09\u94f6\u7eb3\u7c73\u7c92\u5b50\u5bf9\u8c03\u8282\u53e3\u8154\u83cc\u7fa4\u548c\u4fc3\u8fdb\u6d88\u5316\u94fe\u7403\u83cc\u751f\u957f\u7684\u4f5c\u7528\uff1b<\/p>\n

\uff08c\uff09\u591a\u79cd\u7ec6\u83cc\u7684\u80de\u5185\u94f6\u542b\u91cf\uff1b<\/p>\n

\uff08d\uff09\u6d88\u5316\u94fe\u7403\u83cc\u62b5\u6297\u94f6\u7eb3\u7c73\u9897\u7c92\u7684\u53ef\u80fd\u673a\u5236\uff1b<\/p>\n

\uff08e\uff09\u9ad8\u6d53\u5ea6\u7684\u6c27\u5316\u8461\u805a\u7cd6\u548c\u58f3\u805a\u7cd6\u6df7\u5408\u7269\u5f62\u6210\u6c34\u51dd\u80f6\uff1b<\/p>\n

\uff08f\uff09\u4e0a\uff1a\u5316\u5408\u5408\u6210\u94f6\u7eb3\u7c73\u9897\u7c92\uff08AgNP\uff09\u548c\u7ec6\u83cc\u8fd8\u539fAgNP\u7684TEM\uff1b\u4e0b\uff1a\u6c34\u51dd\u80f6SEM\uff1b<\/p>\n

\uff08g-h\uff09\u80bf\u7624\u6d78\u6da6\u6027CD8+T\u7ec6\u80de\u6c34\u5e73\u7684\u6d41\u5f0f\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n

\u56fe\u56db\u3001<\/strong>aPD-1<\/strong>\u548c<\/strong>Agel<\/strong>\u5728<\/strong>OSCC<\/strong>\u76ae\u4e0b\u8377\u7624\u5c0f\u9f20\u4e2d\u7684\u6cbb\u7597\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff094T1\u7ec6\u80de\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08b\uff09\u5728808nm\u6fc0\u5149\u8f90\u7167\u4e0b4T1\u7ec6\u80de\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08c-e\uff09\u4f4e\uff08c\uff09\u3001\u4e2d\u7b49\uff08d\uff09\u3001\u9ad8\uff08e\uff09\u6c34\u5e73\u6d88\u5316\u94fe\u7403\u83cc\u7684\u6cbb\u7597\u6548\u679c\uff1b<\/p>\n

\uff08f\uff09\u8377\u7624\u5c0f\u9f20\u7684\u751f\u7269\u53d1\u5149\u6210\u50cf\uff1b<\/p>\n

\uff08g\uff09\u8377\u7624\u5c0f\u9f20\u7684\u751f\u5b58\u66f2\u7ebf\u3002<\/p>\n

\u56fe\u4e94\u3001<\/strong>aPD-1<\/strong>\u548c<\/strong>Agel<\/strong>\u5728<\/strong>OSCC<\/strong>\u81ea\u53d1\u8377\u7624\u5c0f\u9f20\u4e2d\u7684\u6cbb\u7597\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u6cbb\u7597\u65f6\u95f4\u7ebf\uff1b<\/p>\n

\uff08b\uff09\u6cbb\u7597\u7ed3\u675f\u540e\u5c0f\u9f20\u7684\u820c\u90e8\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09\u6cbb\u7597\u7ed3\u675f\u540e\u5c0f\u9f20\u7684\u75c5\u7406\u6027\u6539\u53d8\uff1b<\/p>\n

\uff08d\uff09\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2dCD8+T\u7ec6\u80de\u548c\u6811\u7a81\u7ec6\u80de\u7684\u6d41\u5f0f\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

\uff08e\uff09\u81ea\u53d1\u6027OSCC\u4e2d\u7684\u6d88\u5316\u94fe\u7403\u83cc\u6c34\u5e73\uff1b<\/p>\n

\uff08f-g\uff09\u53e3\u8154\u83cc\u7fa4\u79cd\u5c5e\u7684PcoA\u56fe\uff08f\uff09\u548c\u73af\u72b6\u56fe\uff08g\uff09\uff1b<\/p>\n

\uff08h\uff09\u538c\u6c27\u6d88\u5316\u94fe\u7403\u83cc\u3001aPD-1\u548cAgel\u6291\u52364MOSC1\u80bf\u7624\u751f\u957f\u548c\u63d0\u9ad8\u7624\u5185CD8+T\u7ec6\u80de\u6d78\u6da6\u60c5\u51b5\uff1b<\/p>\n

\uff08i\uff09\u538c\u6c27\u6d88\u5316\u94fe\u7403\u83cc\u3001aPD-1\u548cAgel\u6291\u52364MOSC2\u80bf\u7624\u751f\u957f\u548c\u63d0\u9ad8\u7624\u5185CD8+T\u7ec6\u80de\u6d78\u6da6\u60c5\u51b5\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma<\/a>, Nature Biomedical Engineering<\/em>, 2021<\/strong>, DOI: 10.1038\/s41551-021-00807-9.<\/p>\n","protected":false},"excerpt":{"rendered":"

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