{"id":227954,"date":"2021-10-03T06:04:28","date_gmt":"2021-10-02T22:04:28","guid":{"rendered":"\/\/m.iemloyee.com\/?p=227954"},"modified":"2021-10-02T20:04:42","modified_gmt":"2021-10-02T12:04:42","slug":"nat-nano-%ef%bc%9a%e7%99%8c%e7%97%87%e5%a4%96%e7%a7%91%e6%89%8b%e6%9c%af%e8%bf%8e%e6%9d%a5%e5%a5%bd%e5%b8%ae%e6%89%8b","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=227954","title":{"rendered":"Nat. Nano.\uff1a\u764c\u75c7\u5916\u79d1\u624b\u672f\u8fce\u6765\u597d\u5e2e\u624b"},"content":{"rendered":"<p><strong>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n<p>\u4e0e\u5b9e\u4f53\u7403\u5f62\u80bf\u7624\u4e0d\u540c\uff0c\u6709\u4e9b\u764c\u75c7\u8bf8\u5982\u95f4\u76ae\u7624\u3001\u64ad\u6563\u6027\u5375\u5de2\u764c\u7b49\u4f1a\u5728\u590d\u6742\u7684\u7ec4\u7ec7\u8868\u9762\u8fdb\u884c\u6269\u6563\uff0c\u50cf\u7247\u5c42\u4e00\u6837\u8986\u76d6\u8fd9\u4e9b\u7ec4\u7ec7\uff0c\u8fd9\u5bf9\u4e34\u5e8a\u4f1a\u8bca\u6765\u8bf4\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\uff0c\u76ee\u524d\u4e5f\u6ca1\u6709\u975e\u5e38\u6709\u6548\u7684\u63aa\u65bd\u6765\u8fdb\u884c\u6cbb\u7597\u3002\u4e0e\u7403\u5f62\u5b9e\u4f53\u7624\u4e0d\u540c\uff0c\u4e0a\u8ff0\u764c\u75c7\u5177\u6709\u72ec\u7279\u7684\u89e3\u5256\u5b66\u610f\u4e49\uff0c\u56e0\u6b64\u901a\u8fc7\u624b\u672f\u5b9e\u73b0\u8fd9\u7c7b\u764c\u75c7\u5728\u7ec4\u7ec7\u4e2d\u7684\u65e0\u7624\u8fb9\u754c\u51e0\u4e4e\u662f\u4e0d\u53ef\u80fd\u7684\uff0c\u6700\u7ec8\u8fd8\u6781\u5bb9\u6613\u9020\u6210\u5c40\u90e8\u590d\u53d1\u60c5\u51b5\u3002\u56e0\u6b64\uff0c\u5982\u679c\u80fd\u5728\u5916\u79d1\u624b\u672f\u671f\u95f4\u8fdb\u884c\u5c40\u90e8\u6cbb\u7597\u5bf9\u4e8e\u6e05\u9664\u6b8b\u4f59\u80bf\u7624\u6765\u8bf4\u6216\u8bb8\u5177\u6709\u91cd\u5927\u7684\u4e34\u5e8a\u4ef7\u503c\u3002\u4e3a\u4e86\u8fbe\u5230\u8fd9\u4e00\u76ee\u7684\uff0c\u6cbb\u7597\u624b\u6bb5\u9700\u8981\u5230\u8fbe\u9690\u85cf\u5728\u590d\u6742\u7ec4\u7ec7\u8868\u9762\u7684\u5fae\u5c0f\u80bf\u7624\u75c5\u7076\uff0c\u4ee5\u6b64\u83b7\u5f97\u66f4\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u9488\u5bf9\u8fd9\u4e00\u6311\u6218\uff0c<strong>\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684<\/strong><strong>Joel P. Schneider\u4e0eChuong D. Hoang<\/strong>\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u5408\u4f5c\u6784\u5efa\u4e86\u4e00\u79cd\u591a\u80bd\u57fa\u7684\u8868\u9762\u586b\u5145\u6c34\u51dd\u80f6\uff08SFH\uff09\uff0c\u5728\u624b\u672f\u671f\u95f4\uff0c\u53ef\u901a\u8fc7\u6ce8\u5c04\u6216\u8005\u55b7\u96fe\u7684\u65b9\u5f0f\u9012\u9001\u5230\u8868\u9762\u764c\u75c7\u533a\u57df\u8fdb\u884c\u6cbb\u7597\u3002\u4e00\u65e6\u8fdb\u884c\u65bd\u836f\uff0cSFH\u53ef\u4ee5\u6839\u636e\u7ec4\u7ec7\u8fdb\u884c\u5f62\u53d8\u5e76\u91ca\u653emicroRNA\u7eb3\u7c73\u9897\u7c92\u548c\u65e0\u5e8f\u80bd\u8fdb\u5165\u764c\u75c7\u7ec6\u80de\u5e76\u51cf\u5f31\u5176\u81f4\u764c\u7279\u5f81\u3002\u51ed\u501f\u8fd9\u4e00\u5355\u4e00\u6cbb\u7597\u6cd5\uff0cSFH\u5728\u95f4\u76ae\u7624\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u53d6\u5f97\u4e86\u4e00\u5b9a\u7684\u6548\u679c\uff0c\u4ece\u800c\u6709\u671b\u6539\u53d8\u8868\u9762\u764c\u75c7\u7684\u6cbb\u7597\u65b9\u5f0f\u3002<strong>\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u4e3a<\/strong><strong>Poulami Majumder\u548cAnand Singh<\/strong>\uff0c\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201cSurface-fill hydrogel attenuates the oncogenic signature of complex anatomical surface cancer in a single application\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<strong>Nature Nanotechnology<\/strong>\u4e0a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227961\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u9898\u56fe-1.jpg\" alt=\"\" width=\"600\" height=\"263\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u9898\u56fe-1.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u9898\u56fe-1-300x132.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001<\/strong><strong>SFH<\/strong><strong>\u5728\u590d\u6742\u8868\u9762\u764c\u75c7\u4e0a\u7684\u5e94\u7528<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227955\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/1-20.jpg\" alt=\"\" width=\"481\" height=\"816\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/1-20.jpg 481w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/1-20-177x300.jpg 177w\" sizes=\"(max-width: 481px) 100vw, 481px\" \/><\/p>\n<p>\uff08a\uff09SFH\u53ef\u4ee5\u901a\u8fc7\u55b7\u96fe\u6216\u8005\u6ce8\u5c04\u7684\u65b9\u5f0f\u8fdb\u5165\u80f8\u819c\u8154\u8fdb\u884c\u57fa\u7840\u6cbb\u7597\uff0c\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u95f4\u76ae\u7624\u5916\u79d1\u624b\u672f\u51cf\u7624\u540e\u7684\u8f85\u52a9\u6cbb\u7597\u624b\u6bb5\uff1b<\/p>\n<p>\uff08b\uff09SFH\u5236\u5907\u7684\u4e24\u4e2a\u9636\u6bb5\uff1a\u9636\u6bb5\u4e00\uff0c\u590d\u5408\u5316\u5b66\u6539\u6027\u53cc\u94femiRNA\u5f62\u6210\u65e0\u5e8f\u80bd\u4ece\u800c\u6700\u7ec8\u5236\u5907\u7eb3\u7c73\u9897\u7c92\uff1b\u9636\u6bb5\u4e8c\uff0c\u9897\u7c92\u968f\u540e\u88ab\u88c5\u8f7d\u8fdb\u7ea4\u7ef4\u72b6\u6c34\u51dd\u80f6\u4e2d\u3002<\/p>\n<p><strong>\u56fe\u4e8c\u3001<\/strong><strong>miRNA<\/strong><strong>\u7eb3\u7c73\u9897\u7c92\u7684\u6784\u5efa\u3001\u7269\u7406\u8868\u5f81\u53ca\u8f6c\u67d3\u6548\u7387<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227956\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/2-20.jpg\" alt=\"\" width=\"600\" height=\"402\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/2-20.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/2-20-300x201.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u7528\u4e8emiRNA\u9897\u7c92\u5236\u5907\u7684\u5019\u9009\u591a\u80bd\u7684\u5e8f\u5217\u4ee5\u53ca\u5404\u79cd\u591a\u80bd\u7684\u952e\u5408\u7b49\u6e29\u7ebf\uff1b<\/p>\n<p>\uff08b\uff0925\u6444\u6c0f\u5ea6\u65f6\uff0c\u5728\u6c34\u4e2d\u4ee5\u4e0d\u540c\u6469\u5c14\u6bd4\uff08\u53ca\u5176\u54cd\u5e94\u7684\u7535\u8377\u6bd4\u4f8b\uff0c\u53caN\uff08\u6c28\u57fa\uff09:P\uff08\u78f7\u9178\u76d0\uff09\uff09\u5236\u5907\u7684miRNA\u7684zeta\u7535\u4f4d\uff1b<\/p>\n<p>\uff08c,d\uff09H2052\u95f4\u76ae\u7624\u7ec6\u80de\u5229\u7528\u7eb3\u7c73\u9897\u7c92\u8fdb\u884c\u5904\u74060.5\u5c0f\u65f6\uff08c\uff09\u6216\u80054\u5c0f\u65f6\uff08d\uff09\u65f6\u7684\u5171\u805a\u7126\u56fe\u50cf\uff0c\u8fd9\u4e9b\u7eb3\u7c73\u9897\u7c92\u542b\u6709\u4e0e\u591a\u80bd1\u590d\u5408\u7684FAM-miRNA\uff08N:P=10:1\uff09\uff1b<\/p>\n<p>\uff08e,f\uff09\u9897\u7c92N:P=1:1\u65f6\uff0c\u7ec6\u80de\u5904\u74060.5\u5c0f\u65f6\uff08e\uff09\u6216\u80054\u5c0f\u65f6\uff08f\uff09\u65f6\u7684\u5171\u805a\u7126\u56fe\u50cf\uff1b<\/p>\n<p>\uff08g\uff09 \u591a\u80bd\u53ca\u5176\u4e0emiRNA\u5728\u4e0d\u540c\u7535\u8377\u6bd4\u4e0b\u590d\u5408\u7684\u5706\u4e8c\u8272\u8c31;<\/p>\n<p>\uff08h\uff09 \u591a\u80bd1\u7ed3\u5408\u5230miRNA\u4e0a\u7684\u6784\u8c61\u6001\u6a21\u578b;<\/p>\n<p>\uff08i\uff0910:1 (N:P) \u591a\u80bd1\uff1amiRNA\u7684\u51b7\u51bb\u7535\u5b50\u5fae\u56fe\u50cf;<\/p>\n<p>\uff08j\uff09 1:1 (N:P) \u591a\u80bd1\uff1amiRNA\u7684\u51b7\u51bb\u7535\u5b50\u5fae\u56fe\u50cf;<\/p>\n<p>\uff08k\uff09\u4e0e\u5546\u7528\u4ea7\u54c1\u6bd4\u8f83\uff0c10:1 (N:P)\u9897\u7c92\u8fdb\u5165H2052\u7ec6\u80de\u7684\u8f6c\u67d3\u6548\u7387;<\/p>\n<p>\uff08l\uff0910:1 (N:P)\u9897\u7c92\u8fdb\u5165H2052\u7ec6\u80de\u7684\u8f6c\u67d3\u884c\u4e3a\u4e0e\u5185\u541e\u6291\u5236\u5242\u7684\u5173\u7cfb\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001<\/strong><strong>Peptide 1\u2013miRNA-215<\/strong><strong>\u548c<\/strong><strong>peptide 1\u2013miRNA-206<\/strong><strong>\u7eb3\u7c73\u9897\u7c92\u5728\u4f53\u5916\u51cf\u5f31\u95f4\u76ae\u7624\u7684\u81f4\u764c\u7279\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227957\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/3-19.jpg\" alt=\"\" width=\"559\" height=\"727\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/3-19.jpg 559w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/3-19-231x300.jpg 231w\" sizes=\"(max-width: 559px) 100vw, 559px\" \/><\/p>\n<p>\uff08a\uff09miRNA-215\u6c89\u9ed8\u5173\u952e\u57fa\u56e0\u5bf9\u4e8e\u95f4\u76ae\u7624\u7624\u5f62\u6210\u6765\u8bf4\u5341\u5206\u91cd\u8981\uff1b<\/p>\n<p>\uff08b\uff09miRNA-215\u7eb3\u7c73\u9897\u7c92\u5728H2052\u7ec6\u80de\u4e2d\u4e0b\u964d\u76ee\u6807\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\uff1b<\/p>\n<p>\uff08c\uff09miRNA-206\u9776\u5411\u57fa\u56e0\uff1b<\/p>\n<p>\uff08d\uff09miRNA-206\u7eb3\u7c73\u9897\u7c92\u5728H2052\u7ec6\u80de\u4e2d\u4e0b\u964d\u76ee\u6807\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\uff1b<\/p>\n<p>\uff08e\uff09\u5229\u7528\u9012\u9001miRNA-215\u548cmiRNA-206\u7684\u7eb3\u7c73\u9897\u7c92\u5904\u74063\u5929\u548c5\u5929\u540e\u7684H2052\u7ec6\u80de\u7684\u7ec6\u80de\u751f\u5b58\u7387;<\/p>\n<p>\uff08f\uff09\u5229\u7528\u9012\u9001miRNA-215\u548cmiRNA-206\u7684\u7eb3\u7c73\u9897\u7c92\u5904\u74062\u5468\u540e\u7684H2052\u7ec6\u80de\u7684\u96c6\u843d\u5f62\u6210\u60c5\u51b5;<\/p>\n<p>\uff08g\uff09\u5229\u7528\u9012\u9001miRNA-215\u548cmiRNA-206\u7684\u7eb3\u7c73\u9897\u7c92\u5904\u74066\u5468\u540e\u7684anchorage\u76f8\u5173\u7684\u7ec6\u80de\u4e09\u7ef4\u751f\u957f;<\/p>\n<p>\uff08h\uff09\u4e09\u7ef4\u96c6\u843d\u5f62\u6210\u7684\u5b9a\u91cf\u3002<\/p>\n<p><strong>\u56fe\u56db\u3001<\/strong><strong>SFH<\/strong><strong>\u7684\u5f62\u6210\u548c\u7269\u7406\u8868\u5f81<\/strong><\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227958\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/4-19.jpg\" alt=\"\" width=\"600\" height=\"294\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/4-19.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/4-19-300x147.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff091wt%SFH\u7684\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u56fe\u50cf\u5c55\u793a\u4e86\u5d4c\u5165\u5230\u7ea4\u7ef4\u72b6\u51dd\u80f6\u7f51\u7edc\u4e2d\u7684miRNA\u7eb3\u7c73\u9897\u7c92\uff1b<\/p>\n<p>\uff08b\uff090.5wt%\u548c1wt%SFH\u968f\u7740\u65f6\u95f4\u91ca\u653emiRNA\u9897\u7c92\uff1b<\/p>\n<p>\uff08c\uff09SFH\u7684\u65f6\u95f4\u626b\u63cf\u526a\u5207\u53d8\u7a00\/\u590d\u539f\u632f\u8361\u6d41\u53d8\u5b66\uff1b<\/p>\n<p>\uff08d\uff09SFH\u88ab\u55b7\u6d82\u5230\u732a\u80ba\u4e0a\uff1b<\/p>\n<p>\uff08e\uff09\u88ab\u55b7\u6d82\u5230\u73bb\u7483\u8868\u9762\u7684SFH\u7684\u5171\u805a\u7126\u56fe\u50cf\uff1b<\/p>\n<p>\uff08f\uff09\uff08e\uff09\u4e2dSFH\u539a\u5ea6\u7684\u5b9a\u91cf\uff1b<\/p>\n<p>\uff08g\uff09SFH\u88ab\u6ce8\u5c04\u5230\u732a\u80ba\u8868\u9762\uff1b<\/p>\n<p>\uff08h\uff09SFH\u6ce8\u5c04\u5230\u6cc4\u6c14\u80ba\u4ee5\u53ca\u73bb\u7483\u5ba4\u8868\u9762\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe\u4e94\u3001<\/strong><strong>SFH<\/strong><strong>\u7684\u4f53\u5185\u9012\u9001\u53ca\u5176\u6297\u764c\u4f5c\u7528<\/strong><\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227959\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/5-14.jpg\" alt=\"\" width=\"600\" height=\"566\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/5-14.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/5-14-300x283.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff090.5wt%\u548c1wt%SFH\u5c40\u90e8\u9012\u9001Cy3\u6807\u8bb0\u7684miRNA\u7eb3\u7c73\u9897\u7c92\uff1b<\/p>\n<p>\uff08b\uff09\u5229\u7528\u8d85\u58f0\u76d1\u6d4b1wt%SFH\u7684\u751f\u7269\u964d\u89e3\u8fc7\u7a0b\uff1b<\/p>\n<p>\uff08c\uff09\u7624\u5468\u6ce8\u5c04SFH\u9012\u9001miRNA\u9897\u7c92\u8fdb\u5165\u7ec6\u80de\uff1b<\/p>\n<p>\uff08d\uff09\u76ae\u4e0b\u79fb\u690dH2373\u80bf\u7624\u4f53\u79ef\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n<p>\uff08e\uff09SFH\u6ce8\u5c04\u56db\u5468\u540e\u5207\u9664\u7684\u80bf\u7624\u56fe\u50cf\uff1b<\/p>\n<p>\uff08f,g\uff09\u80bf\u7624\u7ec4\u7ec7\u7684\u514d\u75ab\u5316\u5b66\u8bc4\u4ef7\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe\u516d\u3001\u95f4\u76ae\u7624\u79fb\u690d\u6a21\u578b\u9610\u91ca<\/strong><strong>SFH<\/strong><strong>\u7684\u6cbb\u7597\u6f5c\u529b<\/strong><\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227960\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/6-7.jpg\" alt=\"\" width=\"600\" height=\"621\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/6-7.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/6-7-290x300.jpg 290w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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href=\"https:\/\/www.nature.com\/articles\/s41565-021-00961-w?utm_source=xmol&amp;utm_medium=affiliate&amp;utm_content=meta&amp;utm_campaign=DDCN_1_GL01_metadata\" target=\"_blank\" rel=\"noopener\">Surface-fill hydrogel attenuates the oncogenic signature of complex anatomical surface cancer in a single application<\/a>, <em>Nature Nanotechnology<\/em>, <strong>2021<\/strong>, DOI: 10.1038\/s41565-021-00961-w.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 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