{"id":227099,"date":"2021-09-15T06:30:02","date_gmt":"2021-09-14T22:30:02","guid":{"rendered":"\/\/m.iemloyee.com\/?p=227099"},"modified":"2021-09-14T18:16:24","modified_gmt":"2021-09-14T10:16:24","slug":"nature-chemistry%ef%bc%9a%e7%ba%b3%e7%b1%b3%e9%a2%97%e7%b2%92%e4%b8%8e%e5%b8%a6%e7%9b%b8%e5%8f%8d%e7%94%b5%e8%8d%b7%e7%9a%84%e5%b0%8f%e5%88%86%e5%ad%90%e7%9a%84%e9%9d%99%e7%94%b5%e5%85%b1%e7%bb%84","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=227099","title":{"rendered":"Nature Chemistry\uff1a\u7eb3\u7c73\u9897\u7c92\u4e0e\u5e26\u76f8\u53cd\u7535\u8377\u7684\u5c0f\u5206\u5b50\u7684\u9759\u7535\u5171\u7ec4\u88c5"},"content":{"rendered":"<p><strong>\u80cc\u666f\u4ecb\u7ecd<\/strong><\/p>\n<p>\u7eb3\u7c73\u5316\u5b66\uff08nanochemistry\uff09\u4e3b\u8981\u7814\u7a76\u539f\u5b50\u4ee5\u4e0a\u3001100nm\u4ee5\u4e0b\u7684\u7eb3\u7c73\u4e16\u754c\u4e2d\u7684\u5404\u79cd\u5316\u5b66\u95ee\u9898\u7684\u79d1\u5b66\u3002\u5728\u4e00\u4e2a\u88ab\u5e7f\u6cdb\u5f15\u7528\u7684\u4f8b\u5b50\u4e2d\uff0c\u914d\u4f53\u4fdd\u62a4\u7684\u91d1\u5c5e\u7eb3\u7c73\u56e2\u7c07\u8868\u73b0\u51fa\u91cf\u5316\u7684\u80fd\u7ea7\uff0c\u5e38\u88ab\u79f0\u4e3a\u201c\u8d85\u539f\u5b50\u201d\u3002\u7eb3\u7c73\u9897\u7c92\uff08NPs\uff09\u4e5f\u53ef\u4ee5\u5728\u7c7b\u4f3c\u4e8e\u5c0f\u5206\u5b50\u805a\u5408\u7684\u8fc7\u7a0b\u4e2d\u7ec4\u88c5\u6210\u4e00\u7ef4(1D)\u7ed3\u6784\uff1b\u4e8b\u5b9e\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u7ecf\u5e38\u5229\u7528\u7535\u5b50\u663e\u5fae\u955c\u89c2\u5bdf\u7eb3\u7c73\u7c92\u5b50\u7684\u81ea\u7ec4\u88c5\u80fd\u529b\u6765\u9a8c\u8bc1\u5206\u5b50\u805a\u5408\u7406\u8bba\u6a21\u578b\u3002\u5e93\u4ed1\u76f8\u4e92\u4f5c\u7528\u53ef\u4ee5\u7528\u6765\u5c06\u5e26\u7535\u7eb3\u7c73\u7c92\u5b50\u7ec4\u88c5\u6210\u66f4\u9ad8\u9636\u7684\u7ed3\u6784\uff0c\u4f46\u8fd9\u4e2a\u8fc7\u7a0b\u9700\u8981\u5c3a\u5bf8\u76f8\u8fd1\u7684\u5e26\u76f8\u53cd\u7535\u8377\u7684\u7c92\u5b50\u3002\u5206\u5b50\u5c3a\u5ea6\u548c\u7eb3\u7c73\u5c3a\u5ea6\u9897\u7c92\u4e4b\u95f4\u7684\u7c7b\u6bd4\u8fd8\u5ef6\u4f38\u5230\u5316\u5b66\u53cd\u5e94\u3002\u4e0e\u5206\u5b50\u7c7b\u4f3c\uff0cNPs\u53ef\u4ee5\u4e0e\u81ea\u8eab\u53d1\u751f\u53cd\u5e94\uff0c\u53d7\u5230\u6c27\u5316\u3001\u9633\u79bb\u5b50\u548c\u9634\u79bb\u5b50\u4ea4\u6362\u7b49\u4f5c\u7528\uff0c\u4ee5\u53ca\u5176\u4ed6\u66f4\u590d\u6742\u7684\u53cd\u5e94\uff0c\u5982\u7535\u5076\u7f6e\u6362\u7b49\u3002<\/p>\n<p>\u540c\u6837\uff0c\u7531\u591a\u4e2a\u5e26\u7535\u57fa\u56e2(\u5178\u578b\u7684\u662fCOO<sup>&#8211;<\/sup>\u548cNMe<sup>3+ <\/sup>)\u529f\u80fd\u5316\u7684\u7403\u5f62\u7eb3\u7c73\u7c92\u5b50\u5728\u8bb8\u591a\u65b9\u9762\u8868\u73b0\u5f97\u50cf\u7b80\u5355\u79bb\u5b50\u7684\u7eb3\u7c73\u7c7b\u4f3c\u7269\u3002\u8fd9\u4e9b\u2018\u8d85\u79bb\u5b50\u2019\u53ef\u4ee5\u4f5c\u4e3a\u7535\u4e2d\u6027\u56fa\u4f53\u76f8\u4e92\u5438\u5f15\uff0c\u4ece\u6eb6\u6db2\u4e2d\u6790\u51fa\uff0c\u7c7b\u4f3c\u4e8e\u7b80\u5355\u7684\u65e0\u673a\u76d0\uff0c\u5982AgI\u3002\u7136\u800c\uff0c\u5c0f\u79bb\u5b50\u4e0e\u5e26\u7535\u7eb3\u7c73\u9897\u7c92\u7684\u884c\u4e3a\u5b58\u5728\u4e00\u4e9b\u663e\u8457\u5dee\u5f02\u3002\u56e0\u6b64\uff0c\u5bfb\u627e\u5c0f\u5206\u5b50\u6765\u4ecb\u5bfc\u7eb3\u7c73\u7c92\u5b50\u7ec4\u88c5\uff0c\u5c06\u4f1a\u5bf9\u7eb3\u7c73\u6750\u6599\u7684\u5236\u5907\u4ee5\u53ca\u5176\u5728\u50ac\u5316\u3001\u4f20\u611f\u548c\u5149\u5b50\u5b66\u7b49\u9886\u57df\u7684\u5e94\u7528\u63d0\u4f9b\u4fbf\u5229\u3002<\/p>\n<p><strong><b>\u6210\u679c\u7b80\u4ecb<\/b><\/strong><\/p>\n<p>\u8fdb\u65e5\uff0c\u4ee5\u8272\u5217\u9b4f\u8328\u66fc\u79d1\u5b66\u7814\u7a76\u6240Rafal Klajn\u56e2\u961f\u53d1\u73b0\u5e263\u4e2a(\u6216\u66f4\u591a)\u7535\u8377\u7684\u5c0f\u5206\u5b50\u53ef\u4ee5\u4ecb\u5bfc\u5e26\u76f8\u53cd\u7535\u8377\u7684\u7eb3\u7c73\u7c92\u5b50\u4e4b\u95f4\u7684\u5438\u5f15\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u53ef\u4ee5\u5f15\u5bfc\u5e26\u7535\u7eb3\u7c73\u7c92\u5b50\u7ec4\u88c5\u6210\u4ee5\u524d\u53ea\u88ab\u8ba4\u4e3a\u662f\u7531\u5b83\u4eec\u4e0e\u76f8\u540c\u5c3a\u5bf8\u7684\u5e26\u7535\u7eb3\u7c73\u7c92\u5b50\u5171\u7ed3\u6676\u5f62\u6210\u7684\u9ad8\u8d28\u91cf\u80f6\u4f53\u6676\u4f53\u3002\u5229\u7528\u5e26\u6b63\u7535\u8377\u7684\u7eb3\u7c73\u9897\u7c92\u548c\u5e26\u8d1f\u7535\u8377\u7684\u9634\u79bb\u5b50\u7ed3\u5408\uff0c\u53ef\u4ee5\u751f\u6210\u77ac\u65f6\u7eb3\u7c73\u9897\u7c92\u7ec4\u88c5\u4f53\u3002MD\u6a21\u62df\u53d1\u73b0\uff0c\u5c06NPs\u805a\u96c6\u5728\u4e00\u8d77\u7684\u5be1\u805a\u9634\u79bb\u5b50\u8868\u73b0\u4e3a\u4e00\u79cd\u2018\u52a8\u6001\u79bb\u5b50\u80f6\u2019\uff0c\u4ece\u800c\u6709\u5229\u4e8eNP\u805a\u96c6\u4f53\u7684\u7ed3\u6784\u8f6c\u53d8\u3002\u672c\u5de5\u4f5c\u7684\u7814\u7a76\u7ed3\u679c\u4e3a\u6c34\u73af\u5883\u4e2d\u9759\u6001\u548c\u52a8\u6001\u7eb3\u7c73\u7ed3\u6784\u6750\u6599\u7684\u5236\u5907\u548c\u5e94\u7528\u63d0\u4f9b\u4e86\u65b9\u5411\u3002\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a\u201cElectrostatic co-assembly of nanoparticles with oppositely charged small molecules into static and dynamic superstructures\u201d\u53d1\u8868\u5728\u4e86Nature Chemistry\u4e0a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227109\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/11-1.png\" alt=\"\" width=\"600\" height=\"317\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/11-1.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/11-1-300x159.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u00a0\u56fe\u6587\u89e3\u6790<\/strong><\/p>\n<p><strong style=\"line-height: 1.5;\"><b>\u4e00\u3001\u5e26\u6b63\u7535\u8377\u7684\u7eb3\u7c73\u9897\u7c92\u4e0e\u5c0f\u9634\u79bb\u5b50\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/b><\/strong><\/p>\n<p>\u8003\u8651\u5e26\u76f8\u53cd\u7535\u8377\u7684\u7eb3\u7c73\u9897\u7c92\u4e0e\u5206\u5b50\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u65f6\u9700\u8981\u89e3\u51b3\u7684\u4e00\u4e2a\u57fa\u672c\u95ee\u9898\uff1a\u4e00\u4e2a\u5c0f\u5206\u5b50\u9700\u8981\u7684\u6700\u5c0f\u7535\u8377\u6570\u662f\u591a\u5c11\uff0c\u624d\u80fd\u4e0e\u76f8\u53cd\u7535\u8377\u7684NPs\u5728\u6c34\u4e2d\u4ea7\u751f\u5438\u5f15\u4f5c\u7528\uff0c\u4ece\u800c\u4ecb\u5bfc\u5b83\u4eec\u7684\u81ea\u7ec4\u88c5?\u4e3a\u6b64\uff0c\u4f5c\u8005\u5408\u6210\u4e86\u4e0d\u540c\u5c3a\u5bf8\u7684(11-\u5def\u57fa\u5341\u4e00\u70f7\u57fa)-N,N,N-\u4e09\u7532\u57fa\u94f5(TMA)\u529f\u80fd\u5316\u7684\u7403\u5f62\u91d1\u7eb3\u7c73\u7c92\u5b50\uff1b\u4f5c\u8005\u4ee5\u5e26\u6b63\u7535\u8377\u7684\u94f5\u57fa\u7ec8\u6b62\uff0c\u5e76\u7814\u7a76\u4e86\u5b83\u4eec\u4e0e\u7b80\u5355\u9634\u79bb\u5b50\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u672c\u5de5\u4f5c\u4f7f\u7528I<sup>&#8211;<\/sup>\u6ef4\u5b9aAg<sup>+<\/sup>\uff0c\u4ece\u6ef4\u5b9a\u66f2\u7ebf\u53ef\u4ee5\u770b\u51fa\uff0c\u5f53\u8fbe\u5230\u6eb6\u89e3\u4ea7\u7269Ksp=[A<sup>+<\/sup>] [B<sup>&#8211;<\/sup>]\u65f6\uff0c\u7a81\u7136\u53d1\u751f\u6c89\u6dc0\u3002\u76f8\u53cd\uff0c\u5c06\u5e26\u6b63\u7535\u8377\u7684\u7eb3\u7c73\u9897\u7c92\u4e0e\u5e26\u8d1f\u7535\u8377\u7684\u7eb3\u7c73\u9897\u7c92\u6ef4\u5b9a\uff0c\u5bfc\u81f4\u7eb3\u7c73\u9897\u7c92\u56e2\u805a\u4f53\u5c3a\u5bf8\u9010\u6e10\u589e\u5927\uff0c\u76f4\u81f3\u7535\u4e2d\u6027\u70b9\u53d1\u751f\u6c89\u6dc0(\u5373\u52a0\u5165\u7684\u7eb3\u7c73\u9897\u7c92\u4e0a\u5e26\u6b63\u7535\u8377\u7684\u914d\u4f53\u6570\u91cf\u8fbe\u5230\u88ab\u6ef4\u5b9a\u7684\u7eb3\u7c73\u9897\u7c92\u4e0a\u5e26\u8d1f\u7535\u8377\u7684\u914d\u4f53\u6570\u91cf)\u3002\u8fdb\u4e00\u6b65\u52a0\u5165\u5e26\u8d1f\u7535\u8377\u7684NPs\u4f1a\u5bfc\u81f4\u6c89\u6dc0\u7269\u6eb6\u89e3\u5e76\u5f62\u6210\u8d8a\u6765\u8d8a\u5c0f\u7684\u9897\u7c92NP\u805a\u96c6\u4f53\uff0c\u5bf9\u4e8e\u5c0f\u7684\u3001\u975e\u7edc\u5408\u7684\u9634\u79bb\u5b50\u6ca1\u6709\u89c2\u5bdf\u5230\u3002<strong><b>\u672c\u5de5\u4f5c\u53d1\u73b0\uff0c\u5e263\u4e2a(\u6216\u66f4\u591a)\u7535\u8377\u7684\u5c0f\u5206\u5b50\u53ef\u4ee5\u4ecb\u5bfc\u5e26\u76f8\u53cd\u7535\u8377\u7684\u7eb3\u7c73\u7c92\u5b50\u4e4b\u95f4\u7684\u5438\u5f15\u76f8\u4e92\u4f5c\u7528\uff0c\u800c\u5e261\u4e2a\u62162\u4e2a\u7535\u8377\u7684\u5c0f\u5206\u5b50\u5219\u4e0d\u80fd\u3002<\/b><\/strong>\u4f5c\u8005\u53d1\u73b0\uff0c\u5728\u6574\u4e2a\u6a21\u62df\u8fc7\u7a0b\u4e2d\uff0c\u9634\u79bb\u5b50\u591a\u6b21\u4eceNP\u8868\u9762\u7ed3\u5408\u548c\u89e3\u79bb\uff0c\u8fd9\u4f7f\u5f97\u5b83\u4eec\u4e0eNP\u76f8\u4e92\u4f5c\u7528\u7684\u81ea\u7531\u80fd\u5256\u9762\u5bb9\u6613\u88ab\u53d1\u73b0\u3002d\u22485\u00c5\u5904\u7684\u6781\u5c0f\u503c\u8868\u660e\u6240\u6709\u4e09\u79cd\u9634\u79bb\u5b50\u90fd\u4e0eNP\u7ed3\u5408\u7684\u914d\u4f53\u53d1\u751f\u4e86\u76f8\u4e92\u5438\u5f15\uff0c\u5176\u6781\u5c0f\u503c\u7684\u6df1\u5ea6\u4e0e\u76f8\u4e92\u4f5c\u7528\u81ea\u7531\u80fd\u6210\u6b63\u6bd4\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227100\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72471-4.png\" alt=\"\" width=\"526\" height=\"786\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72471-4.png 526w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72471-4-201x300.png 201w\" sizes=\"(max-width: 526px) 100vw, 526px\" \/><\/p>\n<p>\u56fe1. \u5e26\u6b63\u7535\u8377\u7684NPs\u548c\u5e26\u8d1f\u7535\u8377\u7684\u5c0f\u5206\u5b50\u7684\u9759\u7535\u5171\u7ec4\u88c5<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227101\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72472-3.png\" alt=\"\" width=\"520\" height=\"730\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72472-3.png 520w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72472-3-214x300.png 214w\" sizes=\"(max-width: 520px) 100vw, 520px\" \/><\/p>\n<p>\u56fe2. \u5e26\u6b63\u7535\u8377\u7684NPs\u4e0e\u5c0f\u9634\u79bb\u5b50\u4e4b\u95f4\u7684\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u7684MD\u6a21\u62df<\/p>\n<p><strong style=\"line-height: 1.5;\"><b>\u4e8c\u3001\u7eb3\u7c73\u9897\u7c92-\u5206\u5b50\u79bb\u5b50\u96c6\u5408\u4f53\u5185\u90e8\u5c0f\u79bb\u5b50\u7684\u52a8\u529b\u5b66\u53ca\u5176\u7ed3\u6784\u8f6c\u53d8\u4e3a\u7ed3\u6676\u96c6\u5408\u4f53\u3002<\/b><\/strong><\/p>\n<p>\u4e0a\u8ff0CG-MD\u6a21\u62df\u8868\u660e\uff0c\u67e0\u6aac\u9178\u6839\u79bb\u5b50\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u4ecb\u5bfc\u4e24\u79cd\u5e26\u6b63\u7535\u8377\u7684TMA\u5305\u8986\u7eb3\u7c73\u9897\u7c92\u4e4b\u95f4\u7684\u5438\u5f15\u76f8\u4e92\u4f5c\u7528\u3002\u63a5\u4e0b\u6765\uff0c\u672c\u5de5\u4f5c\u8003\u5bdf\u4e86\u4e24\u79cd\u7ed3\u5408\u7684Au\u00b7TMA NPs\u7684\u56e2\u7c07\u5185\u67e0\u6aac\u9178\u76d0\u7684\u8fc1\u79fb\u7387\u3002\u4e3a\u6b64\uff0c\u4f5c\u8005\u5bf9CG-MD\u6a21\u62df\u8fdb\u884c\u4e86\u6269\u5c55\uff0c\u5206\u6790\u4e86\u5468\u671f\u4e3a0.9 \u03bcs\u52308.4 \u03bcs\u7684\u8f68\u8ff9\u3002\u901a\u8fc7\u8ddf\u8e2aCG-MD\u6a21\u62df\u8fc7\u7a0b\u4e2d\u7684\u5355\u4e2a\u67e0\u6aac\u9178\u76d0\uff0c\u53ef\u4ee5\u76d1\u6d4b\u5b83\u4eec\u5728\u4e09\u79cd\u72b6\u6001\u4e4b\u95f4\u7684\u8f6c\u79fb\u6982\u7387\u3002\u8fd9\u4e9b\u8f6c\u79fb\u6982\u7387\u662f\u4ece\u4e00\u4e2a\u7b80\u5316\u7684CG\u6a21\u578b\u4e2d\u63d0\u53d6\u51fa\u6765\u7684\uff0c\u56e0\u6b64\u5177\u6709\u5b9a\u6027\u7684\u4ef7\u503c\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8ba1\u7b97\u4e86\u4e0d\u540c\u56e2\u7c07\u4e2d\u67e0\u6aac\u9178\u76d0\u7684\u5747\u65b9\u4f4d\u79fb\uff0c\u53d1\u73b0\u2018\u7070\u8272\u2019\u67e0\u6aac\u9178\u76d0\u5728NP\u8868\u9762\u7684\u6269\u6563\u901f\u5ea6\u6bd4\u8f83\u7a33\u5b9a\u7684\u2018\u7ea2\u8272\u2019\u67e0\u6aac\u9178\u76d0\u5feb\u4e00\u4e2a\u6570\u91cf\u7ea7\u5de6\u53f3\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8bc1\u660e\u4e86\u7cfb\u7edf\u7684\u5185\u90e8\u52a8\u529b\u5b66\uff0c\u65e2\u5176\u4e2d<strong><b>\u4e24\u4e2a\u7ed3\u5408NP\u4e4b\u95f4\u754c\u9762\u7684\u67e0\u6aac\u9178\u6bd4\u5355\u4e2aNP\u8868\u9762\u7684\u67e0\u6aac\u9178\u66f4\u52a8\u6001<\/b><\/strong>\u3002MD\u6a21\u62df\u663e\u793a\uff0c\u6b63\u7535\u8377\u7eb3\u7c73\u9897\u7c92\u4e4b\u95f4\u7684\u4f4e\u805a\u9634\u79bb\u5b50\u5bb9\u6613\u6269\u6563\uff0c\u53ef\u80fd\u6709\u5229\u4e8e\u521d\u59cb\u805a\u96c6\u4f53\u8f6c\u53d8\u4e3a\u89c4\u5219\u7684\u7ed3\u6676\u805a\u96c6\u4f53\u3002\u5728\u6e29\u5ea6\u5347\u9ad8(50\u2103)\u65f6\uff0c\u201c\u9000\u706b\u201d\u8fc7\u7a0b\u57281\u5c0f\u65f6\u5185\u5b8c\u6210\uff0c\u5f62\u6210200-300nm\u5bbd\u7684\u80f6\u4f53\u6676\u4f53\uff0c\u6ca1\u6709\u8fdb\u4e00\u6b65\u957f\u5927(\u56fe3d)\u3002\u603b\u7684\u6765\u8bf4\uff0c\u89c2\u5bdf\u5230\u7684Au\u00b7TMA\/\u67e0\u6aac\u9178\u805a\u96c6\u7269\u4e2dNP\u987a\u5e8f\u7684\u589e\u52a0\u652f\u6301\u4e86\u4f4e\u805a\u9634\u79bb\u5b50\u4f5c\u4e3a\u4e00\u79cd\u52a8\u6001\u7684\u89c2\u70b9\uff0c\u800c\u4e0d\u662f\u201c\u51b7\u51bb\u7684\u201d\u79bb\u5b50\u80f6\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227102\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72473-3.png\" alt=\"\" width=\"512\" height=\"796\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72473-3.png 512w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72473-3-193x300.png 193w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><\/p>\n<p>\u56fe3. \u5c0f\u9634\u79bb\u5b50\u7684\u52a8\u529b\u5b66\u548cTMA\u529f\u80fd\u5316Au NPs\u7684\u9000\u706b<\/p>\n<p><strong style=\"line-height: 1.5;\"><b>\u4e09\u3001\u5e26\u76f8\u53cd\u7535\u8377\u7684\u7eb3\u7c73\u7c92\u5b50\u548c\u5c0f\u79bb\u5b50\u7684\u7ed3\u6676\u805a\u96c6\u4f53\u3002<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><\/p>\n<p>\u672c\u5de5\u4f5c\u5047\u8bbe\uff0c\u5e26\u6b63\u7535\u8377\u7684NPs\u4e0e\u5be1\u805a\u9634\u79bb\u5b50\u4e4b\u95f4\u5177\u6709\u5438\u5f15\u529b\u7684\u9759\u7535\u4f5c\u7528\uff0c\u53ef\u4ee5\u7528\u6765\u6784\u5efa\u5927\u7684\u80f6\u4f53\u6676\u4f53(\u2018\u8d85\u6676\u4f53\u2019)\uff0c\u6700\u7ec8\u5f97\u5230\u7eb3\u7c73\u7ed3\u6784\u6750\u6599\u3002\u7531\u4e8e\u56fe3c,d\u6240\u793a\u7684\u9000\u706b\u5b9e\u9a8c\u6ca1\u6709\u63d0\u4f9b\u5927\u4e8e~300nm\u7684\u6676\u7574\uff0c\u4f5c\u8005\u5bfb\u6c42\u53e6\u4e00\u79cd\u65b9\u6cd5\u6765\u5236\u5907NPs\u7684\u6676\u4f53\u7ec4\u88c5\u4f53\u3002\u672c\u5de5\u4f5c\u505a\u4e86\u5927\u91cf\u7814\u7a76\u540e\u53d1\u73b0\uff0c\u78b3\u9178\u94f5\u7684\u52a0\u5165\u8bf1\u5bfc\u4e86\u79bb\u5b50\/\u4e0a\u79bb\u5b50\u6c89\u6dc0\u7684\u91cd\u65b0\u6eb6\u89e3\uff0c(NH<sub>4<\/sub>)<sub>2<\/sub>CO<sub>3<\/sub>\u7684\u81ea\u53d1\u5206\u89e3\u5bfc\u81f4\u4e86\u80f6\u4f53\u6676\u4f53\u7684\u5f62\u6210(\u5927\u7ea624\u5c0f\u65f6)\u3002\u6709\u8da3\u7684\u662f\uff0c\u7ec4\u88c5\u4f53\u7684\u7ed3\u6676\u5ea6\u5e76\u6ca1\u6709\u56e0\u4e3a\u9634\u79bb\u5b50\u4e0a\u5b58\u5728\u8f83\u5927\u7684\u672a\u5e26\u7535\u57fa\u56e2\u800c\u53d7\u5230\u635f\u5bb3\u3002\u4e0d\u8bba\u9634\u79bb\u5b50\u548cNP\u7684\u5927\u5c0f\u662f\u591a\u5c11\uff0c\u5982\u679c\u8c03\u8282NP\u5728\u7ed3\u6676\u8fc7\u7a0b\u4e2d\u7684\u6d53\u5ea6\u57280.16-10\u00a0mg\u00a0ml<sup>-1<\/sup>\u4e4b\u95f4\uff0c\u7ec4\u88c5\u6210\u7684\u7d27\u5bc6\u5806\u79ef\u7684\u80f6\u4f53\u6676\u4f53\u7684\u5e73\u5747\u7c92\u5f84\u4f1a\u4fdd\u6301\u57281-50\u03bcm\u4e4b\u95f4\u3002\u5c31\u91cd\u590d\u5355\u5143\u7ec6\u80de\u6570(&gt; 4000\u4e2a)\u800c\u8a00\uff0c\u5b83\u4eec\u4ee3\u8868\u4e86\u8fc4\u4eca\u4e3a\u6b62\u4ece\u5c0fNPs\u4e2d\u83b7\u5f97\u7684\u4e00\u4e9b\u8d28\u91cf\u6700\u9ad8\u7684\u80f6\u4f53\u6676\u4f53\u3002\u4f5c\u8005\u8ba4\u4e3a\uff0c\u8fd9\u79cd\u957f\u7a0b\u6709\u5e8f\u662f\u7531TMA\u5305\u8986\u7684\u7eb3\u7c73\u9897\u7c92\u4e4b\u95f4\u4e2d\u4ecb\u5be1\u6838\u82f7\u9178\u7684\u6d41\u52a8\u6027\u6240\u4fc3\u6210\u7684\u3002<strong><b>\u8fd9\u79cd\u8fc1\u79fb\u7387(\u7279\u522b\u662f\u5728\u805a\u96c6\u521d\u671f\uff0c\u5f53\u79bb\u5b50\u5f3a\u5ea6\u4ecd\u7136\u6bd4\u8f83\u9ad8\u65f6)\u53ef\u4ee5\u4f7f\u7eb3\u7c73\u7c92\u5b50\u8c03\u6574\u4f4d\u7f6e\uff0c\u4f18\u5316\u805a\u96c6\u5185\u7684\u5806\u79ef\uff0c\u6700\u7ec8\u5f62\u6210\u957f\u7a0b\u6709\u5e8f\u7684\u7ed3\u6676\u3002<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227103\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72474-3.png\" alt=\"\" width=\"600\" height=\"488\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72474-3.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72474-3-300x244.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe4. TMA\u529f\u80fd\u5316\u7684Au NPs\u4e0e\u5c0f\u9634\u79bb\u5b50\u5171\u6676\u4f53\u7684\u81ea\u7ec4\u88c5<\/p>\n<p><strong style=\"line-height: 1.5;\"><b>\u56db\u3001\u8d1f\u7535\u8377\u7eb3\u7c73\u7c92\u5b50\u4e0e\u5c0f\u9633\u79bb\u5b50\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/b><\/strong><\/p>\n<p>\u672c\u5de5\u4f5c\u63a5\u4e0b\u6765\u786e\u5b9a\u4e86\u89c2\u5bdf\u5230\u7684\u81ea\u7ec4\u88c5\u884c\u4e3a\u662f\u5426\u53ef\u4ee5\u6269\u5c55\u5230\u5e26\u8d1f\u7535\u8377\u7684NPs\u548c\u5be1\u805a\u7684\u2018\u53cd\u5411\u2019\u7cfb\u7edf\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0c\u4f5c\u8005\u5408\u6210\u4e86\u542b\u6709\u78fa\u9178\u57fa\u56e2(11 -\u5def\u57fa\u5341\u4e00\u70f7\u78fa\u9178\u76d0(MUS))\u7684\u5def\u57fa\u76844.7nm Au NPs\uff1b\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4f5c\u8005\u4f7f\u7528\u78fa\u9178\u76d0\u800c\u4e0d\u662f\u7fa7\u9178\u76d0\u7aef\u57fa\uff0c\u76ee\u7684\u662f\u4fdd\u8bc1\u6700\u5927\u7a0b\u5ea6\u7684\u53bb\u8d28\u5b50\u5316\u3002\u4f5c\u8005\u5728\u6c34\u4e2d\u6ef4\u52a0OMA<sup>3+<\/sup>\u6c34\u6eb6\u6db2\u81f3MUS\u5305\u8986\u7684Au NPs (\u5373Au\u00b7MUS)\u4e0a\uff0c\u89c2\u5bdf\u5230S\u5f62\u6ef4\u5b9a\u66f2\u7ebf\uff0c\u7c7b\u4f3c\u4e8eAu\u00b7TMA\u4e0e\u5be1\u805a\u9634\u79bb\u5b50\u7684\u6ef4\u5b9a\u66f2\u7ebf\u3002\u540c\u6837\uff0c\u7528Au\u00b7MUS\u6ef4\u5b9aOMA<sup>3+<\/sup>\u6eb6\u6db2\u4e5f\u53ef\u4ee5\u5f97\u5230NP\u56e2\u805a\u4f53\uff0c\u4e14\u56e2\u805a\u4f53\u968f\u7740Au\u00b7MUS\u52a0\u5165\u91cf\u7684\u589e\u52a0\u9010\u6e10\u5206\u89e3(\u56fe5d )\u3002\u672c\u5de5\u4f5c\u5728\u5229\u7528(NH<sub>4<\/sub>)<sub>2<\/sub>CO<sub>3<\/sub>\u63d0\u9ad8\u79bb\u5b50\u5f3a\u5ea6\u7684\u57fa\u7840\u4e0a\uff0c\u7b5b\u9009\u51fa\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u6eb6\u89e3\u7684Au\u00b7MUS\/OMA<sup>3+<\/sup>\u805a\u96c6\u4f53\uff1b\u800c\u4e14\uff0c\u968f\u4e4b\u800c\u6765\u7684\u662f(NH<sub>4<\/sub>)<sub>2<\/sub>CO<sub>3<\/sub>\u7f13\u6162\u5206\u89e3\uff0c\u5f62\u6210\u4e86\u89c4\u6574\u7684\u80f6\u4f53\u6676\u4f53\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227104\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72475-3.png\" alt=\"\" width=\"511\" height=\"813\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72475-3.png 511w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72475-3-189x300.png 189w\" sizes=\"(max-width: 511px) 100vw, 511px\" \/><\/p>\n<p>\u56fe5. \u9759\u7535\u5171\u7ec4\u88c5\u5e26\u8d1f\u7535\u8377\u7684NPs\u548c\u5e26\u6b63\u7535\u8377\u7684\u5c0f\u5206\u5b50<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227105\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72476-2.png\" alt=\"\" width=\"600\" height=\"277\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72476-2.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72476-2-300x139.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u6269\u5c55\u56fe4. \u7531\u5e26\u8d1f\u7535\u8377\u7684\u7eb3\u7c73\u9897\u7c92\u548c\u6709\u673a\u4e09\u805a\u9633\u79bb\u5b50\u5171\u540c\u7ec4\u88c5\u7684\u80f6\u4f53\u6676\u4f53\u7684SEM\u56fe<\/p>\n<p><b><\/b><strong><b>\u4e94\u3001\u5e26\u76f8\u53cd\u7535\u8377\u7684\u7eb3\u7c73\u7c92\u5b50\u548c\u76f8\u53cd\u7535\u8377\u7684\u5c0f\u79bb\u5b50\u7684\u5e73\u8861\u5916\u805a\u96c6\u4f53\u3002<\/b><\/strong><\/p>\n<p><strong><b>\u00a0<\/b><\/strong><\/p>\n<p>\u4e0a\u8ff0\u7ed3\u679c\u8868\u660e\uff0c\u643a\u5e26\u4e09\u4e2a\uff08\u6216\u66f4\u591a\uff09\u8d1f\u7535\u8377\u7684\u5c0f\u9634\u79bb\u5b50\u53ef\u4ee5\u4ecb\u5bfc\u5e26\u6b63\u7535\u8377\u7684NPs\u4e4b\u95f4\u7684\u5438\u5f15\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u4e9b\u9634\u79bb\u5b50\u5728\u5355\u9634\u79bb\u5b50\u6216\u4e8c\u9634\u79bb\u5b50\u5b58\u5728\u4e0b\u4ecd\u7136\u4e0d\u7ec4\u88c5\u3002\u8fd9\u4e9b\u53d1\u73b0\u7684\u57fa\u7840\u4e0a\uff0c\u4f5c\u8005\u5047\u8bbe\uff0cAu\u00b7TMA\u56e2\u805a\u4f53\u4e2d\u201c\u9634\u79bb\u5b50\u80f6\u201d\u7535\u8377\u7684\u81ea\u53d1\u51cf\u5c11\u5e94\u5bfc\u81f4\u8fd9\u4e9b\u56e2\u805a\u4f53\u7684\u89e3\u4f53\u3002\u8fd9\u79cd\u7535\u8377\u51cf\u5c11\u53ef\u80fd\u662f\u591a\u7535\u8377\u9634\u79bb\u5b50\u6c34\u89e3\u7684\u7ed3\u679c\u3002\u8fd9\u6837\u4e00\u4e2a\u8fc7\u7a0b\u7684\u4e00\u4e2a\u4e3b\u8981\u4f8b\u5b50\u662fATP\u6c34\u89e3\u2014\u2014\u7531\u78f7\u9178\u9176\u9176\u50ac\u5316\u7684\u9ad8\u5ea6\u5916\u80fd\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u63a8\u65ad\uff0c\u5728\u78f7\u9178\u9176\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0cATP\u4f1a\u4f5c\u4e3a\u77ed\u6682\u751f\u6210NP\u805a\u96c6\u4f53\u7684\u523a\u6fc0\u7269\u3002\u672c\u5de5\u4f5c\u53d1\u73b0\uff0c\u4f53\u7cfb\u7684\u5e73\u8861\u6001\u5bf9\u5e94ATP\u6c34\u89e3\u6210AMP\u548cHPO<sub>4<\/sub><sup>2-<\/sup>\uff0c\u4e24\u8005\u5747\u4e0d\u8bf1\u5bfcAu\u00b7TMA\u7684\u81ea\u7ec4\u88c5\u3002\u4f46\u662f\uff0c\u7531\u4e8eATP\u6c34\u89e3\u6bd4ATP\u8bf1\u5bfc\u7684NPs\u81ea\u7ec4\u88c5\u6162\uff0c\u53ea\u8981ATP\u6d53\u5ea6\u8db3\u591f\u9ad8\uff0cNP\u56e2\u805a\u4f53\u5c31\u4f1a\u6682\u65f6\u5b58\u5728\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u9a8c\u8bc1NP\u805a\u7269\u7684\u5206\u89e3\u662f\u7531\u5421\u5576\u9176\u7684\u9176\u6d3b\u6027\u89e6\u53d1\u7684\uff0c\u4f5c\u8005\u4f7f\u7528\u4e86\u4e00\u79cd\u4e0d\u53ef\u6c34\u89e3\u7684ATP\u7c7b\u4f3c\u7269\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u672c\u5de5\u4f5c\u53d1\u73b0\uff0c\u867d\u7136\u8fd9\u79cd\u5be1\u805a\u4f53\u8bf1\u5bfc\u4e86\u7c7b\u4f3c\u4e8eATP\u7684NP\u805a\u96c6\uff0c\u4f46\u5728\u9176\u7684\u5b58\u5728\u4e0b\uff0c\u8fd9\u79cd\u805a\u96c6\u5e76\u672a\u51fa\u73b0\u89e3\u4f53\u7684\u8ff9\u8c61\u3002\u6b64\u5916\uff0c\u53cd\u590d\u5faa\u73af\u5bfc\u81f4\u6eb6\u6db2\u7684\u79bb\u5b50\u5f3a\u5ea6\u9010\u6e10\u589e\u52a0\uff0c\u6700\u7ec8\u7531\u4e8eAu\u00b7TMA\u4e0e\u5be1\u9634\u79bb\u5b50\u4e4b\u95f4\u7684\u9759\u7535\u4f5c\u7528\u88ab\u5c4f\u853d\u963b\u6b62NP\u7684\u805a\u96c6\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728ALPase\u5b58\u5728\u4e0b\uff0c\u4f5c\u8005\u89c2\u5bdf\u5230Au\u00b7TMA\u805a\u96c6\u4f53\u7684\u62c6\u5206\u8f6e\u5ed3\u622a\u7136\u4e0d\u540c\uff0c\u8fd9\u53d6\u51b3\u4e8e\u6240\u7528\u7684\u9634\u79bb\u5b50\u3002ATP\u548c\u65e0\u673a\u4e09\u78f7\u9178\u7684\u52a0\u5165\u5747\u4f7f\u7eb3\u7c73\u7c92\u5b50\u8fc5\u901f\u805a\u96c6\u3002\u7136\u800c\uff0c\u867d\u7136Au\u00b7TMA\/ATP\u805a\u96c6\u4f53\u5728\u4e00\u5b9a\u7684\u65f6\u95f4\u5185\u6301\u7eed\u5b58\u5728\uff0c\u4e4b\u540e\u8fc5\u901f\u5206\u89e3\uff0c\u4f46\u4eceP<sub>3<\/sub>O<sub>10<\/sub><sup>5-<\/sup>\u5f97\u5230\u7684\u805a\u96c6\u4f53\u5728\u5f62\u6210\u540e\u4e0d\u4e45\u5c31\u4ee5\u7a33\u5b9a\u7684\u901f\u5ea6\u8fdb\u884c\u5f00\u59cb\u5d29\u89e3\uff0c\u76f4\u5230\u51e0\u5c0f\u65f6\u540e\u518d\u751f\u51fa\u6e38\u79bb\u7eb3\u7c73\u9897\u7c92\u7684\u6eb6\u6db2\u3002\u6700\u540e\uff0c\u4f5c\u8005\u5047\u8bbe\u975e\u5e73\u8861NP\u805a\u96c6\u4f53\u7684\u5bff\u547d\u53ef\u4ee5\u901a\u8fc7\u5916\u52a0\u523a\u6fc0\u91cf\u6765\u63a7\u5236(\u56fe6d\u4e2d\u7684\u7eff\u8272)\u3002\u56fe6k\u663e\u793a\u4e86\u968f\u7740ATP\u6dfb\u52a0\u91cf\u7684\u589e\u52a0\uff0c<em><i>\u03bb<\/i><\/em><sub>SPR<\/sub>\u503c\u5bf9Au\u00b7TMA\u7684\u4f9d\u8d56\u6027\u3002NP\u805a\u96c6\u4f53\u5728\u52a0\u516513.5 nmol ATP\u540e\u7ea620 min\u5f00\u59cb\u5feb\u901f\u62c6\u89e3\uff0c\u800c\u5728\u52a0\u5165\u523a\u6fc0\u7269\u540e\u7ea6180 min\u5f00\u59cb\u62c6\u89e3(40.5 nmol)\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u5728\u67d0\u4e9b\u7ec4\u88c5\u4f53\u5185\u90e8\uff0cATP\u88ab\u8fc5\u901f\u6c34\u89e3\uff0c\u9700\u8981\u4e0d\u65ad\u5730\u8865\u5145ATP\uff0c\u624d\u80fd\u4fdd\u6301\u7ec4\u88c5\u7684\u975e\u5e73\u8861\u72b6\u6001\u3002<strong><b>\u6b64\u5916\uff0c\u672c\u5de5\u4f5c\u7684\u7cfb\u7edf\u5141\u8bb8\u4e00\u4e2a\u72ec\u7acb\u7684\u65b9\u5f0f\u6765\u63a7\u5236\u52a8\u6001NP\u805a\u96c6\u4f53\u7684\u5bff\u547d\uff0c\u8fd9\u662f\u57fa\u4e8e\u6539\u53d8\u9176\u7684\u6d53\u5ea6(\u6d3b\u6027)\u3002<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-227106\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72477-2.png\" alt=\"\" width=\"600\" height=\"536\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72477-2.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/09\/\u56fe\u72477-2-300x268.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe6. \u7531ATP\u9a71\u52a8\u7684Au NPs\u7684DSA<\/p>\n<p><strong><b>\u7ed3\u8bba\u4e0e\u5c55\u671b<\/b><\/strong><\/p>\n<p>\u603b\u7684\u6765\u8bf4\uff0c<strong><b>\u672c\u5de5\u4f5c\u7814\u7a76\u4e86\u5206\u5b50\u548c\u7eb3\u7c73\u5c3a\u5ea6\u4e0a\u7684\u9759\u7535\u4f5c\u7528\uff0c\u91cd\u70b9\u7814\u7a76\u4e86\u5e26\u8d1f\u7535\u8377\u7684\u5c0f\u5206\u5b50\u548c\u5e26\u6b63\u7535\u8377\u7684\u7eb3\u7c73\u7c92\u5b50\u7684\u6a21\u578b\u4f53\u7cfb\u3002<\/b><\/strong>\u672c\u5de5\u4f5c\u53d1\u73b0\uff0c\u5e263\u4e2a(\u6216\u66f4\u591a)\u7535\u8377\u7684\u5c0f\u5206\u5b50\u53ef\u4ee5\u4ecb\u5bfc\u5e26\u76f8\u53cd\u7535\u8377\u7684\u7eb3\u7c73\u7c92\u5b50\u4e4b\u95f4\u7684\u5438\u5f15\u76f8\u4e92\u4f5c\u7528\uff0c\u800c\u5e261\u4e2a\u62162\u4e2a\u7535\u8377\u7684\u5c0f\u5206\u5b50\u5219\u4e0d\u80fd\u3002\u8fd9\u4e9b\u7ed3\u679c\u53ef\u4ee5\u901a\u8fc7\u8212\u5c14\u8328-\u54c8\u4ee3\u89c4\u5219\u5e94\u7528\u4e8e\u5c0f\u7eb3\u7c73\u7c92\u5b50\u4f53\u7cfb\u6765\u52a0\u4ee5\u5408\u7406\u5316\u3002\u7528\u5e26\u76f8\u53cd\u7535\u8377\u7684\u5c0f\u5206\u5b50\u79bb\u5b50\u6ef4\u5b9a\u5e26\u7535\u7eb3\u7c73\u7c92\u5b50\uff0c\u53cd\u4e4b\u4ea6\u53ef\u4ee5\u6ef4\u5b9a\uff0c\u8868\u660e\u4f5c\u8005\u7684\u4f53\u7cfb\u7ed3\u5408\u4e86\u5206\u5b50\u5c3a\u5ea6\u548c\u7eb3\u7c73\u7ea7\u4f53\u7cfb\u7684\u7279\u5f81\u3002MD\u6a21\u62df\u53d1\u73b0\uff0c\u5c06NPs\u805a\u96c6\u5728\u4e00\u8d77\u7684\u5be1\u805a\u9634\u79bb\u5b50\u8868\u73b0\u4e3a\u4e00\u79cd\u2018\u52a8\u6001\u79bb\u5b50\u80f6\u2019\uff0c\u4ece\u800c\u6709\u5229\u4e8eNP\u805a\u96c6\u4f53\u7684\u7ed3\u6784\u8f6c\u53d8\u3002\u4f5c\u8005\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5e26\u76f8\u53cd\u7535\u8377\u7684\u5c0f\u5206\u5b50\u4e0e\u5e26\u6b63\u7535\u8377\u7684\u7eb3\u7c73\u7c92\u5b50\u5171\u7ed3\u6676\uff0c\u5176\u5c3a\u5bf8\u5c0f\u4e8e\u4e00\u4e2a\u6570\u91cf\u7ea7\uff0c\u53ef\u4ee5\u5f62\u6210\u4ee5\u524d\u53ea\u8ba4\u4e3a\u662f\u7531\u76f8\u540c\u5c3a\u5bf8\u7684\u5e26\u76f8\u53cd\u7535\u8377\u7684\u5c0f\u5206\u5b50\u4e0e\u5e26\u6b63\u7535\u8377\u7684\u7eb3\u7c73\u7c92\u5b50\u5171\u7ec4\u88c5\u5f62\u6210\u7684\u9ad8\u8d28\u91cf\u7684\u80f6\u4f53\u6676\u4f53\u3002\u57fa\u4e8e\u4ee5\u4e0a\u53d1\u73b0\uff0c<strong><b>\u4f5c\u8005\u8bbe\u60f3\u4e86\u4e00\u4e2aDSA\u4f53\u7cfb\uff0c\u5373\u7eb3\u7c73\u7c92\u5b50\u53ea\u5728\u591a\u7535\u8377\u9634\u79bb\u5b50\u7684\u6301\u7eed\u4f9b\u5e94\u4e0b\u624d\u4ee5\u805a\u96c6\u6001\u5b58\u5728\uff0c\u8fd9\u4e9b\u9634\u79bb\u5b50\u4e0d\u65ad\u6c34\u89e3\u6210\u8f83\u5c0f\u7684\u9634\u79bb\u5b50\u3002<\/b><\/strong>\u8fd9\u4e9b\u7ed3\u679c\u4e3a\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u5f00\u8f9f\u4e86\u51e0\u4e2a\u9014\u5f84\u3002<strong><b>\uff081\uff09<\/b><\/strong>\u4f5c\u8005\u9884\u671f\uff0c\u57fa\u4e8e\u6325\u53d1\u6027\u76d0\u81ea\u53d1\u5206\u89e3\u7684\u7eb3\u7c73\u9897\u7c92\u6676\u5316\u65b9\u6cd5\u5c06\u5bf9\u6f5c\u5728\u7684\u6676\u5316\u673a\u5236\u63d0\u4f9b\u91cd\u8981\u7684\u89c1\u89e3\u3002<strong><b>\uff082\uff09<\/b><\/strong>NP\/\u79bb\u5b50\u805a\u96c6\u4f53\u5185\u90e8\u7684\u5206\u5b50\u79bb\u5b50\u8868\u73b0\u51fa\u8fc1\u79fb\u6027\u7684\u53d1\u73b0\u8868\u660e\u8fd9\u4e9b\u805a\u96c6\u4f53\u53ef\u80fd\u8868\u73b0\u4e3a\u79bb\u5b50\u5bfc\u4f53\u3002<strong><b>\uff083\uff09<\/b><\/strong>\u5728NP\/\u4e09\u9634\u79bb\u5b50\u805a\u96c6\u4f53\u4f53\u7cfb\u4e2d\u6574\u5408\u4e9a\u7a33\u6001\u5149\u9178\u5c06\u4f1a\u5f88\u6709\u8da3\uff1b\u5149\u8bf1\u5bfc\u7684\u8d28\u5b50\u91ca\u653e\u53ef\u4ee5\u7528\u6765\u8d28\u5b50\u5316\u4e09\u9634\u79bb\u5b50\uff0c\u4ece\u800c\u53ef\u9006\u5730\u5728\u4e09\u9634\u79bb\u5b50\u4e4b\u95f4\u5207\u6362(\u5728\u9ed1\u6697\u6761\u4ef6\u4e0b)\uff1b\u8bf1\u5bfcNP\u805a\u96c6\u548c\u5206\u89e3\uff0c\u4ece\u800c\u62c6\u5378\u548c\u91cd\u7ec4\u591a\u4e2a\u5faa\u73af\u7684NP\u805a\u96c6\u4f53\u3002<strong><b>\uff084\uff09<\/b><\/strong>ATP\u4ecb\u5bfc\u7684DSA\u7cfb\u7edf\u4ee3\u8868\u4e86\u4e00\u4e2a\u7531\u751f\u7269\u76f8\u5bb9\u6027\u7ec4\u5206\u548c\u5728\u6c34\u4e2d\u8fd0\u884c\u7684\u7cfb\u7edf\u7684\u72ec\u7279\u4f8b\u5b50\uff0c\u4ece\u800c\u4f7f\u7814\u7a76\u8005\u66f4\u63a5\u8fd1\u4e8e\u52a8\u6001\u81ea\u7ec4\u88c5NPs\u4e0e\u751f\u7269\u73af\u5883\u7684\u63a5\u53e3\u3002<\/p>\n<p>\u7b2c\u4e00\u4f5c\u8005\uff1aTong Bian<\/p>\n<p>\u901a\u8baf\u4f5c\u8005\uff1aRafal Klajn<\/p>\n<p>\u901a\u8baf\u5355\u4f4d\uff1a\u4ee5\u8272\u5217\u9b4f\u8328\u66fc\u79d1\u5b66\u7814\u7a76\u6240<\/p>\n<p>\u8bba\u6587doi\uff1a<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41557-021-00752-9\"><u>https:\/\/doi.org\/10.1038\/s41557-021-00752-9<\/u><\/a><\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1a<\/p>\n<p>https:\/\/www.nature.com\/articles\/s41557-021-00752-9<\/p>\n<p>\u672c\u6587\u7531\u6e29\u534e\u4f9b\u7a3f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\u4ecb\u7ecd \u7eb3\u7c73\u5316\u5b66\uff08nanochemistry\uff09\u4e3b\u8981\u7814\u7a76\u539f\u5b50\u4ee5\u4e0a\u3001100nm\u4ee5\u4e0b\u7684\u7eb3\u7c73\u4e16\u754c\u4e2d\u7684\u5404\u79cd\u5316\u5b66\u95ee\u9898\u7684\u79d1\u5b66\u3002\u5728\u4e00\u4e2a\u88ab\u5e7f\u6cdb\u5f15\u7528\u7684\u4f8b\u5b50\u4e2d\uff0c\u914d\u4f53\u4fdd\u62a4\u7684\u91d1\u5c5e\u7eb3\u7c73\u56e2&#8230;<\/p>\n","protected":false},"author":11454,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-227099","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/227099"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/11454"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=227099"}],"version-history":[{"count":2,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/227099\/revisions"}],"predecessor-version":[{"id":227111,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/227099\/revisions\/227111"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=227099"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=227099"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=227099"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}