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\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u7531\u8010\u836f\u6027\u7ec6\u83cc\u611f\u67d3\u5bfc\u81f4\u7684\u6b7b\u4ea1\u65e5\u76ca\u589e\u591a\uff0c\u8fd9\u610f\u5473\u7740\u65b0\u578b\u6297\u751f\u7d20\u7c7b\u836f\u7269\u7684\u6cbb\u7597\u5e76\u6ca1\u6709\u53d6\u5f97\u9884\u671f\u7684\u6548\u679c\u3002\u5c3d\u7ba1\u5e7f\u8c31\u7684\u75ab\u82d7\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u80fd\u591f\u5e94\u5bf9\u8fd9\u7c7b\u8010\u836f\u7ec6\u83cc\u611f\u67d3\u7684\u6311\u6218\uff0c\u4f46\u5728\u7ec6\u83cc\u80de\u58c1\u4e0a\u7684\u4e3b\u8981\u6297\u539f\u662f\u5f31\u514d\u75ab\u539f\u6027\u7684\u8840\u6e05\u7279\u5f02\u6027\u591a\u7cd6\uff0c\u65e0\u6cd5\u8f7b\u6613\u652f\u6301\u75ab\u82d7\u7684\u751f\u4ea7\u3002\u8fd8\u6709\u4e00\u7c7b\u7531\u51cf\u6d3b\u7ec6\u83cc\u53d1\u5c55\u51fa\u7684\u7ec6\u83cc\u75ab\u82d7\uff0c\u5176\u5728\u514d\u75ab\u6291\u5236\u578b\u75c5\u4eba\u4e2d\u4f1a\u4ea7\u751f\u989d\u5916\u7684\u526f\u4f5c\u7528\u6548\u679c\u3002\u6b64\u5916\uff0c\u8fd8\u6709\u4e00\u7c7b\u706d\u6d3b\u7684\u7684\u7ec6\u83cc\u6216\u8005\u6bd2\u7d20\u53ef\u4f5c\u4e3a\u75ab\u82d7\uff0c\u4f46\u9274\u4e8e\u7eaf\u5316\u7684\u78b3\u6c34\u5316\u5408\u7269\u75ab\u82d7\u7684\u4f4e\u514d\u75ab\u539f\u6027\u7b49\u7f3a\u9677\uff0c\u8fd9\u7c7b\u6297\u539f\u901a\u5e38\u9700\u8981\u5316\u5b66\u5171\u4ef7\u8fde\u63a5\u5230\u86cb\u767d\u8d28\u4e0a\u4ee5\u589e\u5f3a\u5176\u6548\u7387\u3002\u7136\u800c\uff0c\u4e0a\u8ff0\u7684\u65b9\u6cd5\u90fd\u53ea\u9650\u5b9a\u4e8e\u4e00\u90e8\u5206\u83cc\u682a\uff0c\u540c\u65f6\u8fd8\u9700\u8981\u5bf9\u6297\u539f\u8fdb\u884c\u9002\u5f53\u6539\u6027\u6216\u8005\u5bf9\u75c5\u539f\u4f53\u8fdb\u884c\u9694\u79bb\uff0c\u65e0\u8bba\u4ece\u54ea\u65b9\u9762\u6765\u8bb2\u90fd\u9650\u5236\u4e86\u75ab\u82d7\u7684\u8fdb\u4e00\u6b65\u53d1\u5c55\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u7684<\/strong>David J. Mooney<\/strong>\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u56e2\u961f\u62a5\u9053\u4e86\u4e00\u79cd\u53ef\u6ce8\u5c04\u751f\u7269\u6750\u6599\u75ab\u82d7\uff08ciVAX PAMP\uff09\uff0c\u901a\u8fc7\u62db\u52df\u3001\u91cd\u7f16\u548c\u91ca\u653e\u6811\u7a81\u7ec6\u80de\u53ef\u5bf9\u7ec6\u83cc\u6297\u539f\u4ea7\u751f\u5f3a\u6548\u7684\u4f53\u6db2\u548cT\u7ec6\u80de\u53cd\u5e94\u3002\u8fd9\u4e00\u75ab\u82d7\u7531\u5438\u9644\u4e86\u7c92\u7ec6\u80de-\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08GM-CSF\uff09\u548c\u5bcc\u542bCpG\u7684\u5be1\u6838\u82f7\u9178\u7684\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\uff08MPS\uff09\u652f\u67b6\u6784\u6210\uff0c\u8be5\u652f\u67b6\u8fd8\u96c6\u6210\u4e86\u8868\u9762\u6d82\u8986\u6709\u5e7f\u8c31\u51dd\u96c6\u7d20\uff08FcMBL\uff09\u7684\u8d85\u987a\u78c1\u6027\u5fae\u73e0\uff0c\u53ef\u7528\u4e8e\u78c1\u6027\u6355\u6349\u7531\u706d\u6d3b\u7ec6\u83cc\u80de\u58c1\u884d\u751f\u7684\u6eb6\u83cc\u4ea7\u7269\u7684\u75c5\u539f\u4f53\u76f8\u5173\u7684\u5206\u5b50\u6a21\u5f0f\uff08PAMP\uff09\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9\u4e00\u75ab\u82d7\u53ef\u4ee5\u4fdd\u62a4\u5c0f\u9f20\u62b5\u6297\u8010\u7532\u6c27\u897f\u6797\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u7684\u76ae\u80a4\u611f\u67d3\u3001\u81f4\u547d\u5927\u80a0\u6746\u83cc\u5f15\u53d1\u7684\u611f\u67d3\u6027\u4f11\u514b\u3002\u4f5c\u8005\u8ba4\u4e3a\uff0c\u5f3a\u5927\u7684\u514d\u75ab\u539f\u6027\u3001\u8f83\u4f4e\u7684\u526f\u4f5c\u7528\u53d1\u751f\u7387\u3001\u6a21\u5757\u5316\u7684\u5236\u5907\u8fc7\u7a0b\u7b49\u90fd\u4f7f\u5f97\u8fd9\u4e00\u65b0\u578b\u75ab\u82d7\u6280\u672f\u975e\u5e38\u9002\u7528\u4e8e\u9632\u6b62\u7ec6\u83cc\u6027\u611f\u67d3\u75c5\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cBiomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aNature Biomedical Eneering<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001<\/strong>ciVAX<\/strong>\u75ab\u82d7\u7684\u751f\u4ea7\u548c\u5e94\u7528<\/strong><\/p>\n

\"\"<\/p>\n

 <\/p>\n

\u56fe\u4e8c\u3001\u5728\u751f\u7269\u6750\u6599\u652f\u67b6\u4e2d\uff0c\u652f\u67b6\u62db\u52df\u6811\u7a81\u7ec6\u80de\u5230\u6ce8\u5c04\u4f4d\u70b9\u5e76\u4e14\u4ea7\u751f\u5f3a\u5927\u7684\u4f53\u6db2\u548c\u7ec6\u80de\u514d\u75ab\uff1b\u540c\u65f6\u652f\u67b6\u4e2d\u7684<\/strong>ciVAX<\/strong>\u5219\u53ef\u4ee5\u63d0\u5448\u4e00\u7cfb\u5217\u7ec6\u83cc\u80de\u58c1<\/strong>PAMPs<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5168\u7ec6\u80de\u6eb6\u89e3\u4ea7\u7269\u6ce8\u5c04\u4f4d\u70b9\u7684\u75c5\u7406\u5b66\u548c\u7ec4\u7ec7\u5b66\uff1b<\/p>\n

\uff08b\uff09PAMP\u6ce8\u5c04\u4f4d\u70b9\u7684\u75c5\u7406\u5b66\u548c\u7ec4\u7ec7\u5b66\uff1b<\/p>\n

\uff08c\uff09PAMPs\u3001\u5185\u6bd2\u7d20\u4ee5\u53ca\u5206\u5b50\u91cf\u6807\u8bb0\u7269\u7684\u86cb\u767d\u8d28\u6d53\u5ea6\u6d4b\u91cf\uff1b<\/p>\n

\uff08d\uff09RS218\u5185\u6bd2\u7d20PAMPs\u7684\u4f53\u5916\u7814\u7a76\uff1b<\/p>\n

\uff08e\uff09ciVAX\u4f53\u5916\u91ca\u653eCpG\u3001GM-CSF\u548c\u5185\u6bd2\u7d20\u7684\u52a8\u529b\u5b66\u7814\u7a76\uff0828\u5929\uff09\uff1b<\/p>\n

\uff08f\uff09\u6811\u7a81\u7ec6\u80de\u6570\u76ee\u6d4b\u5b9a\uff1b<\/p>\n

\uff08g\uff09\u6ce8\u5c04\u75ab\u82d7\u540e\u6dcb\u5df4\u7ed3\u4e2d\u7684B\u7ec6\u80de\u548cT\u7ec6\u80de\u6570\u76ee\u3002<\/p>\n

 <\/p>\n

\u56fe\u4e09\u3001<\/strong>ciVAX<\/strong>\u4fdd\u62a4\u5c0f\u9f20\u4e0d\u53d7\u5927\u80a0\u6746\u83cc\u8d25\u8840\u75c7\u611f\u67d3\u4ee5\u53ca\u4fdd\u62a4\u732a\u4e0d\u53d7\u8d25\u8840\u6027\u4f11\u514b\u5371\u5bb3<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a-f\uff09\u542b\u6709GM-CSF\u548cCpG\u7684\u51b7\u5e72MPS\u652f\u67b6\u4e0e\u88abFcMBL\u78c1\u73e0\u6355\u6349\u7684\u5927\u80a0\u6746\u83ccRS218\u6df7\u5408\u5f62\u6210ciVAX\u75ab\u82d7\uff0c\u5176\u4e2d\u96cc\/\u96c4\u5c0f\u9f20\u5206\u522b\u7ecf\u8fc7ciVAX\u75ab\u82d7\u5355\u5242\u63a5\u79cd\u6216\u8005\u4e0d\u542bFcMBL-RS218\u7684\u75ab\u82d7\u63a5\u79cd\u6216\u8005\u4e0d\u63a5\u79cd\u75ab\u82d7\uff0ca-c\u5728\u75ab\u82d7\u63a5\u79cd\u540e35\u5929\u6ce8\u5c04\u5927\u80a0\u6746\u83cc\uff0cd-f\u5728\u75ab\u82d7\u63a5\u79cd\u540e90\u5929\u6ce8\u5c04\u5927\u80a0\u6746\u83cc\uff1b<\/p>\n

\uff08b\uff0ce\uff09\u5668\u5b98\u4e0a\u7ec6\u83cc\u8d1f\u8f7d\u91cf\uff1b<\/p>\n

\uff08c\uff0cf\uff09\u5c0f\u9f20\u8840\u6e05\u4e2d\u63a5\u79cd\u524d\u540eRS218\u7279\u5f02\u6027\u6297\u4f53\u6c34\u5e73\uff1b<\/p>\n

\uff08g-i\uff09ciVAX\u75ab\u82d7\u5bf9\u732a\u6a21\u578b\u8fdb\u884c\u63a5\u79cd\u6cbb\u7597\uff08\u5927\u80a0\u6746\u83cc\u7c7b\u578b\u4e3a\u591a\u836f\u8010\u836f\u768441949\uff09\uff0c\uff08g\uff09\u5b58\u6d3b\u7387\u68c0\u6d4b\uff0c\uff08h\uff09\u808c\u9150\u6c34\u5e73\uff0c\uff08i\uff09\u732a\u7279\u5f02\u6027SOFA\u3002<\/p>\n

 <\/p>\n

\u56fe\u56db\u3001<\/strong>PLG ciVAX<\/strong>\u75ab\u82d7\u53ef\u4ea7\u751f\u6301\u7eed\u7684\u4fdd\u62a4\u6027\u514d\u75ab\u53cd\u5e94\u4ee5\u53ca\u5bf9\u5176\u4ed6\u80a0\u6746\u83cc\u79d1\u611f\u67d3\u8d77\u5230\u4e86\u4ea4\u53c9\u4fdd\u62a4\u4f5c\u7528<\/strong><\/p>\n

\u00a0\"\"<\/strong><\/p>\n

\uff08a-d\uff09PLG ciVAX\u901a\u8fc7\u5c06\u542b\u6709GM-CSF\u548cCpG\u7684PLG\u9178\u652f\u67b6\u4e0e\u88abFcMBL\u78c1\u73e0\u6355\u6349\u7684\u5927\u80a0\u6746\u83ccRS218\u6df7\u5408\u51b7\u5e72\u5f62\u6210\uff1b<\/p>\n

\uff08a\uff09\u96cc\/\u96c4\u5c0f\u9f20\u5206\u522b\u7ecf\u8fc7ciVAX\u75ab\u82d7\u5355\u5242\u63a5\u79cd\u6216\u8005\u4e0d\u542bFcMBL-PAMPs\u7684ciVAX\u75ab\u82d7\u63a5\u79cd\u6216\u8005\u4e0d\u542bGM-CSF\u2013CpGDE \u7684ciVAX\u75ab\u82d7\u63a5\u79cd\u6216\u8005\u5355\u7eafPLG\uff0c\u5728\u75ab\u82d7\u63a5\u79cd\u540e35\u5929\u6ce8\u5c04\u5927\u80a0\u6746\u83cc\uff0c\u5e76\u68c0\u6d4b\u6b7b\u4ea1\u7387\u7b49\uff1b<\/p>\n

\uff08b\uff09\u5668\u5b98\u75c5\u539f\u4f53\u8d1f\u8f7d\u60c5\u51b5\uff1b<\/p>\n

\uff08c\uff09\u96cc\/\u96c4\u5c0f\u9f20\u5206\u522b\u7ecf\u8fc7ciVAX\u75ab\u82d7\u5355\u5242\u63a5\u79cd\u6216\u8005\u4e0d\u542bFcMBL-PAMPs\u7684ciVAX\u75ab\u82d7\u63a5\u79cd\u6216\u8005\u4e0d\u63a5\u79cd\uff0c\u5728\u75ab\u82d7\u63a5\u79cd\u540e90\u5929\u6ce8\u5c04\u5927\u80a0\u6746\u83cc\uff0c\u5e76\u68c0\u6d4b\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08d\uff09\u96cc\/\u96c4\u5c0f\u9f20\u5206\u522b\u7ecf\u8fc7ciVAX\u75ab\u82d7\u53ca\u5404\u7c7b\u5927\u80a0\u6746\u83cc\u5355\u5242\u63a5\u79cd\u540e35\u5929\u518d\u6ce8\u5c04\u5927\u80a0\u6746\u83ccRS218\uff0c\u5e76\u68c0\u6d4b\u5b58\u6d3b\u7387\u3002<\/p>\n

 <\/p>\n

\u56fe\u4e94\u3001<\/strong>ciVAX<\/strong>\u63d0\u4f9b\u529f\u80fd\u5316\u7684\u514d\u75ab\u4fdd\u62a4\u62b5\u6297\u9769\u5170\u6c0f\u9633\u6027\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc<\/strong><\/p>\n

\u00a0\"\"<\/strong><\/p>\n

\uff08a\uff09\u5c0f\u9f20\u63a5\u79cd\u75ab\u82d7\u540e\u8840\u6e05\u4e2dMRSA\u7279\u5f02\u6027\u6297\u4f53\u6c34\u5e73\uff1b<\/p>\n

\uff08b\uff09\u5c0f\u9f20\u5728\u63a5\u79cd\u75ab\u82d7\u540e35\u5929\u6ce8\u5c04MRSA\u5e76\u68c0\u6d4b\u8113\u80bf\u5f62\u6210\u60c5\u51b5\u3002<\/p>\n

 <\/p>\n

\u56fe\u516d\u3001\u4ece\u5927\u80a0\u6746\u83cc\u611f\u67d3\u52a8\u7269\u4e2d\u5236\u5907\u7684<\/strong>ciVAX<\/strong>\u75ab\u82d7\u80fd\u591f\u62b5\u6297\u5176\u4ed6\u5927\u80a0\u6746\u83cc\u8840\u6e05\u578b\u7684\u611f\u67d3<\/strong><\/p>\n

\u00a0\"\"<\/strong><\/p>\n

\uff08a\uff09\u5c0f\u9f20\u63a5\u79cd\u75ab\u82d7\u5e76\u6ce8\u5c04\u81f4\u6b7b\u5242\u91cf\u7684RS218\uff0c\u5e76\u76d1\u6d4b\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08b\uff09\u5668\u5b98\u4e2d\u75c5\u539f\u4f53\u7684\u5b9a\u91cf\u5316\u5206\u6790\u3002<\/p>\n

 <\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0cciVAX PAMP\u75ab\u82d7\u6280\u672f\u80fd\u591f\u63d0\u9ad8\u5bf9\u9769\u5170\u6c0f\u9633\/\u9634\u6027\u7ec6\u83cc\u7684\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u4e00\u75ab\u82d7\u7cfb\u7edf\u53ef\u5728\u8d25\u8840\u75c7\u52a8\u7269\u6a21\u578b\uff08\u7531\u5927\u80a0\u6746\u83cc\u611f\u67d3\u5f15\u8d77\uff09\u4e0a\u5c55\u73b0\u51fa\u6709\u6548\u6551\u547d\u4f5c\u7528\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u8fd9\u4e00\u75ab\u82d7\u4e5f\u5c55\u73b0\u51fa\u4e86\u5bf9\u591a\u836f\u8010\u836f\u7ec6\u83cc\u7684\u5e7f\u8c31\u4f5c\u7528\uff0c\u8868\u660e\u8fd9\u4e00\u6280\u672f\u53ef\u6709\u671b\u66ff\u4ee3\u6297\u751f\u7d20\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n

 <\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock,<\/strong> Nature Biomedical Engineering<\/em><\/a>, 2021<\/strong>, DOI: 10.1038\/s41551-021-00756-3.<\/p>\n","protected":false},"excerpt":{"rendered":"

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