{"id":224633,"date":"2021-07-20T06:07:54","date_gmt":"2021-07-19T22:07:54","guid":{"rendered":"\/\/m.iemloyee.com\/?p=224633"},"modified":"2021-07-19T21:08:57","modified_gmt":"2021-07-19T13:08:57","slug":"%e7%ba%b3%e7%b1%b3%e5%8c%bb%e8%8d%af%e9%a2%86%e5%9f%9f%e5%a4%a7%e7%89%9b%ef%bc%9achad-a-mirkin%e3%80%81%e6%96%bd%e5%89%91%e6%9e%97%e3%80%81%e5%88%98%e5%ba%84%e3%80%81%e5%88%98%e5%b0%8f%e5%88%9a","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=224633","title":{"rendered":"\u7eb3\u7c73\u533b\u836f\u9886\u57df\u5927\u725b\uff1aChad A. Mirkin\u3001\u65bd\u5251\u6797\u3001\u5218\u5e84\u3001\u5218\u5c0f\u521a\u5de5\u4f5c\u8fdb\u5c55"},"content":{"rendered":"<p><strong><b>\u4eba\u7269\u4ecb\u7ecd:<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><\/p>\n<p><strong><b>Chad A. Mirkin<\/b><\/strong>\u4e3a\u7f8e\u56fd\u79d1\u5b66\u9662\u3001\u533b\u5b66\u9662\u3001\u5de5\u7a0b\u9662\u548c\u7f8e\u56fd\u827a\u672f\u4e0e\u79d1\u5b66\u9662\u56db\u9662\u9662\u58eb\uff0c\u66fe\u4efb\u7f8e\u56fd\u603b\u7edf\u5965\u5df4\u9a6c\u7684\u79d1\u6280\u987e\u95ee\uff0c\u73b0\u4efb\u7f8e\u56fd\u897f\u5317\u5927\u5b66\u5316\u5b66\u7cfb\u3001\u533b\u5b66\u7cfb\u4ee5\u53ca\u6750\u6599\u5de5\u7a0b\u7cfb\u6559\u6388\u30022017\u5e74\u5f53\u9009\u4e3a\u4e2d\u56fd\u79d1\u5b66\u9662\u5916\u7c4d\u9662\u58eb\u3002\u4ed6\u5f00\u521b\u4e86\u5168\u65b0\u7684\u7403\u5f62\u6838\u9178\u5206\u5b50\uff0c\u6539\u53d8\u4e86\u5bf9\u6838\u9178\u5206\u5b50\u7684\u4f20\u7edf\u8ba4\u8bc6\uff0c\u5f15\u53d1\u4e86\u5168\u4e16\u754c\u4f7f\u7528\u660e\u786e\u7eb3\u7c73\u7ed3\u6784\u4f5c\u4e3a\u65b0\u578b\u6807\u8bb0\u7269\u8fdb\u884c\u751f\u7269\u68c0\u6d4b\u548c\u75be\u75c5\u8bca\u7597\u7814\u7a76\u7684\u70ed\u6f6e\u3002\u4ed6\u662f\u56fd\u9645\u7eb3\u7c73\u6280\u672f\u6743\u5a01\u671f\u520a\u4e4b\u4e00Small\u7684\u521b\u529e\u8005\uff0c\u8fd8\u62c5\u4efb\u4e86Acc. Chem. Res.\u3001Angew. Chem.\u3001Adv. Mater.\u7b4920\u4f59\u4e2a\u56fd\u9645\u6027\u6742\u5fd7\u7684\u7f16\u8f91\u987e\u95ee\uff0c\u73b0\u5df2\u53d1\u8868\u6587\u7ae0700\u591a\u7bc7\uff0c\u62e5\u6709\u4e13\u52291000\u591a\u9879\u3002Chad A. Mirkin\u8fd8\u521b\u529e\u4e865\u5bb6\u516c\u53f8\uff0c\u7528\u4ee5\u4fc3\u8fdb\u7eb3\u7c73\u6280\u672f\u5728\u751f\u547d\u79d1\u5b66\u548c\u534a\u5bfc\u4f53\u5de5\u4e1a\u9886\u57df\u7684\u5546\u4e1a\u5316\u5e94\u7528\u3002\u00a0<\/p>\n<p><strong><b>\u65bd\u5251\u6797<\/b><\/strong>\uff0c2019\u5e74\u5f53\u9009\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\uff0c\u53d1\u8868SCI\u8bba\u6587500\u4f59\u7bc7\uff0cSCI\u4ed6\u4eba\u5f15\u752839,000\u4f59\u6b21\uff0cH-index\u4e3a112\uff0c\u5e76\u88abThomson Reuters\u9009\u4e3a2015\u81f32019\u5e74\u5ea6\u5168\u7403\u9ad8\u88ab\u5f15\u79d1\u5b66\u5bb6\u3002\u7814\u7a76\u65b9\u5411\u4e3a\u4ecb\u5b54\u7eb3\u7c73\u9897\u7c92\u7684\u53ef\u63a7\u5408\u6210\u53ca\u5176\u751f\u7269\u76f8\u5bb9\u6027\u3001\u591a\u529f\u80fd\u5316\u3001\u836f\u7269\u8f93\u8fd0\u548c\u7eb3\u7c73\u8bca\u7597\u5242\u7b49\u65b9\u9762\u3002\u4ed6\u8fd8\u63d0\u51fa\u4e86\u201c\u7eb3\u7c73\u50ac\u5316\u533b\u5b66\u201d\u7684\u5168\u65b0\u7814\u7a76\u524d\u6cbf\u65b9\u5411\uff0c\u4f7f\u7528\u65e0\u6bd2\u7eb3\u7c73\u9897\u7c92\u800c\u4e0d\u4f7f\u7528\u4f20\u7edf\u7684\u6709\u6bd2\u5316\u7597\u836f\u7269\uff0c\u901a\u8fc7\u5f15\u53d1\u7624\u5185\u539f\u4f4d\u7684\u50ac\u5316\u53cd\u5e94\u8fbe\u5230\u6297\u80bf\u7624\u76ee\u7684\u3002<\/p>\n<p><strong><b>\u5218\u5c0f\u521a<\/b><\/strong>\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u6559\u6388\uff0c\u5176\u7814\u7a76\u9886\u57df\u5305\u62ec\u5149\u5b66\u7eb3\u7c73\u6750\u6599\u548c\u80fd\u91cf\u8f6c\u79fb\uff0c\u81f4\u529b\u4e8e\u63a2\u7d22\u5c06\u53d1\u5149\u7eb3\u7c73\u6676\u4f53\u7528\u4e8e\u5149\u50ac\u5316\u3001\u4f20\u611f\u548c\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u3002\u5218\u6559\u6388\u5728Science\u3001Nature\u7b49\u56fd\u9645\u9876\u7ea7\u5b66\u672f\u671f\u520a\u4e0a\u53d1\u8868\u8bba\u6587200\u591a\u7bc7\u3002\u8fde\u7eed\u591a\u5e74\u88ab\u6c64\u59c6\u68ee\u8def\u900f\u96c6\u56e2\u7edf\u8ba1\u4e3a\u56fd\u9645\u9ad8\u88ab\u5f15\u5b66\u8005\uff0c\u662f2016\u5e74\u65b0\u52a0\u5761\u79d1\u6280\u6700\u9ad8\u5956\u2014\u2014\u603b\u7edf\u79d1\u5b66\u5956\u5f97\u4e3b\uff0c2017\u5e74\u83b7\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u6770\u51fa\u7814\u7a76\u5458\u5956\u3002\u76ee\u524d\uff0c\u62c5\u4efbNanoscale\u526f\u4e3b\u7f16\uff0c\u5e76\u62c5\u4efbAdvanced Optical Materials\u3001Journal of Luminescence\u3001Journal of Physical Chemistry Letters\u7b49\u671f\u520a\u7684\u7f16\u59d4\u3002<\/p>\n<p><strong><b>\u5218\u5e84<\/b><\/strong>\uff0c\u00a0\u82cf\u5dde\u5927\u5b66\u6559\u6388\uff0c\u8fd1\u5e74\u6765\u5728\u751f\u7269\u6750\u6599\u4e0e\u80bf\u7624\u7eb3\u7c73\u6280\u672f\u9886\u57df\u4ece\u4e8b\u7814\u7a76\uff0c\u56f4\u7ed5\u80bf\u7624\u8bca\u7597\u4e2d\u7684\u82e5\u5e72\u6311\u6218\u6027\u95ee\u9898\uff0c\u53d1\u5c55\u4e86\u4e00\u7cfb\u5217\u65b0\u578b\u7eb3\u7c73\u63a2\u9488\u7528\u4e8e\u4f53\u5916\u751f\u7269\u68c0\u6d4b\u4e0e\u6d3b\u4f53\u5206\u5b50\u5f71\u50cf\uff0c\u5e76\u63a2\u7d22\u4e86\u591a\u79cd\u57fa\u4e8e\u7eb3\u7c73\u6280\u672f\u548c\u751f\u7269\u6750\u6599\u7684\u80bf\u7624\u5149\u5b66\u6cbb\u7597\u3001\u653e\u5c04\u6cbb\u7597\u3001\u4e0e\u514d\u75ab\u6cbb\u7597\u65b0\u7b56\u7565\u3002\u5171\u53d1\u8868\u5b66\u672f\u8bba\u6587320\u4f59\u7bc7\uff0c\u8bba\u6587\u603b\u5f15\u7528\u8d85\u8fc760,000\u6b21\uff0cSCI H-index \u4e3a134\u30022014\u5e74\u8d77\u8fde\u7eed\u5165\u56f4Elsevier\u51fa\u7248\u793e\u53d1\u5e03\u7684\u201c\u4e2d\u56fd\u9ad8\u88ab\u5f15\u7528\u5b66\u8005\u699c\u5355\u201d\uff08\u6750\u6599\u79d1\u5b66\u7c7b\uff09\uff1b2015\u5e74\u8d77\u8fde\u7eed\u5165\u9009\u7f8e\u56fd\u7f8e\u56fd\u79d1\u777f\u552f\u5b89\uff08\u539f\u6c64\u68ee\u8def\u900f\u96c6\u56e2\uff09\u516c\u5e03\u7684\u201c\u5168\u7403\u9ad8\u88ab\u5f15\u79d1\u5b66\u5bb6\u540d\u5355\u201d\uff08Highly Cited Researchers\uff09\u3002\u83b7\u56fd\u5bb6\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u3001\u57fa\u91d1\u59d4\u4f18\u79c0\u9752\u5e74\u57fa\u91d1\u3001\u6c5f\u82cf\u7701\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u7684\u8d44\u52a9\u3002<\/p>\n<p><strong><b>\u7814\u7a76\u8fdb\u5c55\uff1a<\/b><\/strong><\/p>\n<p><strong><b>J<\/b><\/strong><strong><b>ACS<\/b><\/strong><strong><b>\uff1a<\/b><\/strong><strong><b>\u7528\u4e8e\u6d3b\u7ec6\u80de\u5316\u5b66\u5206\u6790\u7684\u86cb\u767d\u7403\u5f62\u6838\u9178<\/b><\/strong><\/p>\n<p><strong><b>\u7f8e\u56fd\u897f\u5317\u5927\u5b66\u7684<\/b><\/strong><strong><b>Chad A. Mirkin\u7b49<\/b><\/strong><strong><b>\u4eba<\/b><\/strong>\u62a5\u9053\u4e86\u4e00\u79cd\u57fa\u4e8e\u86cb\u767d\u8d28\u7403\u5f62\u6838\u9178(ProSNAs)\u7684\u6d3b\u7ec6\u80de\u5316\u5b66\u5206\u6790\u65b0\u7b56\u7565\u7684\u8fdb\u5c55\u3002 ProSNAs\u7ed3\u6784\u53ef\u4ee5\u901a\u8fc7\u9ad8\u5ea6\u53ef\u7f16\u7a0b\u7684\u6838\u9178\u5916\u58f3\u6216\u529f\u80fd\u86cb\u767d\u6838\u5fc3\u8fdb\u884c\u5206\u6790\u68c0\u6d4b\u3002\u4f5c\u4e3a\u4e00\u4e2a\u6982\u5ff5\u8bc1\u660e\uff0c\u4f7f\u7528i-\u57fa\u5e8f\u4f5c\u4e3a\u6838\u9178\u8bc6\u522b\u5143\u4ef6\u6765\u63a2\u6d4b\u6d3b\u7ec6\u80de\u7684pH\u503c\u3002\u901a\u8fc7\u5c06i-\u57fa\u5e8f\u4e0e\u5f3a\u5236\u63d2\u5165\u8bfb\u51fa\u63a5\u53e3\uff0c\u5f15\u5165\u4e86\u4e00\u79cd\u6297\u5047\u9633\u6027\u4fe1\u53f7\u7684\u65e0\u731d\u706d\u5668\u65b9\u6cd5\uff0c\u514b\u670d\u4e86\u4f20\u7edf\u57fa\u4e8e\u8367\u5149\u56e2\/\u731d\u706d\u5668\u7684\u91d1\u7eb3\u7c73\u8000\u6591\u76f8\u5173\u7684\u5c40\u9650\u6027\u3002\u5229\u7528\u8461\u8404\u7cd6\u6c27\u5316\u9176\u4f5c\u4e3a\u529f\u80fd\u86cb\u767d\u6838\u5fc3\uff0c\u7814\u7a76\u5c55\u793a\u4e86\u57fa\u4e8e\u6d3b\u6027\u7684\u8461\u8404\u7cd6\u653e\u5927\u4f20\u611f\u3002\u8fd9\u79cd\u9176\u4fc3\u7cfb\u7edf\u7684\u8367\u5149\u5f00\u542f\u7387\u5927\u4e8e100\u500d\uff0c\u5728\u5b58\u5728\u7c7b\u4f3c\u7269\u7684\u60c5\u51b5\u4e0b\u5bf9\u8461\u8404\u7cd6\u5177\u6709\u9009\u62e9\u6027\uff0c\u5e76\u4e14\u53ef\u4ee5\u68c0\u6d4b\u5230\u9ad8\u4e8e\u7ea65\u03bcM\u9608\u503c\u6d53\u5ea6\u7684\u8461\u8404\u7cd6\u3002\u7ec6\u80de\u5185\u8461\u8404\u7cd6\u6d53\u5ea6\u76f8\u5bf9\u53d8\u5316\u7684\u7814\u7a76\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201cProtein Spherical Nucleic Acids for Live-Cell Chemical Analysis\u201d\u53d1\u8868\u5728JACS\u4e0a\u3002DOI:\u00a010.1021\/jacs.0c06866<\/p>\n<p>\u56fe1\u00a0\u63a2\u9488\u7ed3\u6784\u4ee5\u53ca\u5de5\u4f5c\u673a\u7406<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224635\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-2-17.png\" alt=\"\" width=\"600\" height=\"810\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-2-17.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-2-17-222x300.png 222w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>J<\/b><\/strong><strong><b>ACS<\/b><\/strong><strong><b>\uff1a<\/b><\/strong><strong><b>\u57fa\u4e8eDNA\u7684\u7eb3\u7c73\u7ed3\u6784\u7528\u4e8e\u6d3b\u7ec6\u80de\u5206\u6790<\/b><\/strong><\/p>\n<p>\u57fa\u4e8eDNA\u7684\u63a2\u9488\u7531\u4e8e\u5176\u8bc6\u522b\u6838\u9178\u548c\u975e\u6838\u9178\u76ee\u6807\u7684\u80fd\u529b\uff0c\u6613\u4e8e\u5408\u6210\u548c\u5316\u5b66\u4fee\u9970\uff0c\u6613\u4e0e\u4fe1\u53f7\u653e\u5927\u65b9\u6848\u63a5\u53e3\uff0c\u4ee5\u53ca\u56fa\u6709\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u6784\u6210\u4e86\u4e00\u4e2a\u591a\u529f\u80fd\u7684\u751f\u7269\u6d4b\u91cf\u5e73\u53f0\u3002<strong><b>\u7f8e\u56fd\u897f\u5317\u5927\u5b66\u7684<\/b><\/strong><strong><b>Chad A. Mirkin\u7b49<\/b><\/strong><strong><b>\u4eba<\/b><\/strong>\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5386\u53f2\u7684\u89c6\u89d2\uff0c\u9610\u8ff0\u4e86\u4ece\u7ebf\u6027DNA\u7ed3\u6784\u5230\u66f4\u590d\u6742\u7684\u7eb3\u7c73\u7ed3\u6784\u7684\u8f6c\u53d8\u662f\u5982\u4f55\u5f7b\u5e95\u6539\u53d8\u4e86\u6d3b\u7ec6\u80de\u5206\u6790\u3002\u901a\u8fc7\u5bf9\u7ed3\u6784\u7684\u8c03\u8282\uff0c\u53ef\u4ee5\u4ea7\u751f\u65e0\u9700\u8f6c\u67d3\u8bd5\u5242\u5c31\u80fd\u8fdb\u5165\u7ec6\u80de\u7684\u63a2\u9488\uff0c\u5e76\u53ef\u4ee5\u5728\u5355\u7ec6\u80de\u5668\u3001\u5355\u7ec6\u80de\u3001\u7ec4\u7ec7\u5207\u7247\u548c\u6574\u4e2a\u751f\u7269\u4f53\u6c34\u5e73\u4e0a\u68c0\u6d4b\u3001\u8ddf\u8e2a\u548c\u91cf\u5316\u6d3b\u7ec6\u80de\u4e2d\u7684\u5206\u6790\u7269\u3002\u7814\u7a76\u63cf\u8ff0\u4e86\u4e0d\u540c\u63a2\u9488\u7ed3\u6784\u7684\u4f18\u70b9\u548c\u7f3a\u70b9\uff0c\u5e76\u63cf\u8ff0\u4e86\u8fd9\u4e9b\u7ed3\u6784\u5728\u9610\u660e\u57fa\u7840\u751f\u7269\u5b66\u4ee5\u53ca\u5f00\u53d1\u6539\u8fdb\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u7cfb\u7edf\u65b9\u9762\u6240\u5e26\u6765\u7684\u8fdb\u5c55\u3002\u8fd8\u8ba8\u8bba\u4e86\u8be5\u9886\u57df\u7684\u7a81\u51fa\u6311\u6218\uff0c\u5e76\u6982\u8ff0\u4e86\u53ef\u80fd\u7684\u89e3\u51b3\u65b9\u6848\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cDNA-Based Nanostructures for Live-Cell Analysis\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728JACS\u4e0a\u3002DOI: 10.1021\/jacs.0c04978<\/p>\n<p>\u56fe2\u00a0\u7528\u4e8e\u7814\u7a76\u7ec6\u80de\u5206\u6790\u7269\u7684DNA\u63a2\u9488\u8fdb\u5316\u7684\u65f6\u95f4\u8f74<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224634\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-1-16.png\" alt=\"\" width=\"600\" height=\"316\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-1-16.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-1-16-300x158.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>Na<\/b><\/strong><strong><b>ture Commun<\/b><\/strong><strong><b>.\uff1a\u80bf\u7624\u5185\u7eb3\u7c73\u87af\u5408\u7269\u7684\u539f\u4f4d\u5408\u6210\u548c\u80bf\u7624\u9ad8\u6548\u50ac\u5316\u6cbb\u7597<\/b><\/strong><\/p>\n<p>\u94c1\u80c6\u58a8\u6c34\u5f15\u53d1\u7684\u5316\u5b66\u8150\u8680\u662f\u897f\u65b9\u6587\u5316\u9057\u4ea7\u624b\u5199\u6587\u732e\u7684\u4e00\u5927\u5a01\u80c1\uff0c\u8fd9\u662f\u7531\u4e8e\u94c1\u79bb\u5b50\u548c\u6ca1\u98df\u5b50\u9178\uff08GA\uff09\u751f\u6210\u516d\u914d\u4f4d\u7684GA-Fe\u87af\u5408\u4fc3\u8fdb\u6d3b\u6027\u6c27\u7684\u751f\u6210\u3002\u8fd9\u4e00\u73b0\u8c61\u542f\u53d1\u5c06GA-Fe\u7684\u4fc3\u6c27\u5316\u673a\u5236\u5e94\u7528\u4e8e\u6297\u764c\u6cbb\u7597\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c<strong><b>\u4e2d\u79d1\u9662\u4e0a\u6d77\u7845\u9178\u76d0\u7814\u7a76\u6240\u65bd\u5251\u6797\u9662\u58eb\u7b49\u4eba<\/b><\/strong>\u6784\u5efa\u4e86\u94c1\u63ba\u6742\u7684\u7a7a\u5fc3\u4ecb\u5b54\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\uff08Fe-HMSNs\uff09\uff0c\u5e76\u5c06\u6ca1\u98df\u5b50\u9178\u76d0\u8d1f\u8f7d\u5728\u7a7a\u8154\u4e2d\uff0c\u6765\u5b9e\u73b0\u5bf9\u80bf\u7624\u7684\u50ac\u5316\u6cbb\u7597\u3002\u8fd9\u79cd\u590d\u5408\u7eb3\u7c73\u4f53\u7cfb\u5728\u80bf\u7624\u9178\u6027\u73af\u5883\u4e2d\u964d\u89e3\u91ca\u653e\u51faFe<sup>3+<\/sup>\u548c\u6ca1\u98df\u5b50\u9178\u76d0\uff0c\u539f\u4f4d\u5408\u6210GA-Fe\u7eb3\u7c73\u9897\u7c92\uff0c\u5177\u6709\u9ad8\u5ea6\u8fd8\u539f\u914d\u4f53\u573a\u7684\u7eb3\u7c73\u590d\u5408\u7269\u53ef\u4ee5\u4fc3\u8fdb\u6c27\u8fd8\u539f\u53cd\u5e94\u751f\u6210\u8fc7\u6c27\u5316\u6c22\u3002\u6b64\u5916\uff0c\u6240\u5408\u6210\u7684GA-Fe\u53cc\u7535\u5b50\u6c27\u5316\u5f62\u5f0f\u662f\u4e00\u79cd\u5f88\u597d\u7684\u7c7bFenton\u8bd5\u5242\uff0c\u53ef\u4ee5\u50ac\u5316\u8fc7\u6c27\u5316\u6c22\u5206\u89e3\u6210\u7f9f\u57fa\u81ea\u7531\u57fa\uff0c\u6700\u7ec8\u5bf9\u80bf\u7624\u4ea7\u751f\u4e25\u91cd\u7684\u6c27\u5316\u635f\u4f24\u3002\u8fd9\u79cd\u80bf\u7624\u5185\u5408\u6210GA-Fe\u7eb3\u7c73\u91d1\u5c5e\u87af\u5408\u7269\u7684\u6cbb\u7597\u65b9\u6cd5\u53ef\u80fd\u5bf9\u672a\u6765\u7684\u6297\u764c\u7814\u7a76\u5177\u6709\u6307\u5bfc\u610f\u4e49\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cIntratumoral synthesis of nano-metalchelate for\u00a0tumor catalytic therapy by ligand field-enhanced\u00a0coordination\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Nature\u00a0Commun.\u4e0a\u3002DOI: 10.1038\/s41467-021-23710-y<\/p>\n<p>\u56fe3\u00a0\u7eb3\u7c73\u836f\u7269FHPG\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\u7684\u5316\u5b66\u673a\u5236\u793a\u610f\u56fe<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224636\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-3-16.png\" alt=\"\" width=\"600\" height=\"683\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-3-16.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-3-16-264x300.png 264w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>A<\/b><\/strong><strong><b>M<\/b><\/strong><strong><b>\uff1a\u7eb3\u7c73\u50ac\u5316\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u7ebf\u7c92\u4f53\u6fc0\u6d3b\u514d\u75ab\u5b9e\u73b0\u80bf\u7624\u6cbb\u7597<\/b><\/strong><\/p>\n<p>\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u5728\u4fdd\u62a4\u4eba\u4f53\u514d\u53d7\u80bf\u7624\u7684\u53d1\u751f\u53ca\u589e\u6b96\u7b49\u65b9\u9762\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u4fdd\u62a4\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u88ab\u80bf\u7624\u7684\u514d\u75ab\u6291\u5236\u529f\u80fd\u6240\u62b5\u6d88\u3002\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u79cd\u514d\u75ab\u6291\u5236\u662f\u7531\u80bf\u7624\u514d\u75ab\u8010\u53d7\u7684\u5fae\u73af\u5883\u6240\u8bf1\u5bfc\u4ea7\u751f\u7684\uff0c\u5305\u62ec\u514d\u75ab\u529f\u80fd\u8017\u7aed\u7684\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de(CTLs)\u548c\u4fc3\u8fdb\u80bf\u7624\u589e\u6b96\u7684M2\u6781\u5316\u5de8\u566c\u7ec6\u80de\u3002\u00a0<strong><b>\u4e2d\u79d1\u9662\u4e0a\u6d77\u7845\u9178\u76d0\u7814\u7a76\u6240\u80e1\u840d\u3001\u65bd\u5251\u6797\u9662\u58eb\u7b49\u4eba<\/b><\/strong>\u00a0\u63d0\u51fa\u4e86\u4e00\u79cd\u5229\u7528\u7eb3\u7c73\u50ac\u5316\u5242\u7279\u5f02\u6027\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u7ebf\u7c92\u4f53DNA(mtDNA)\u53d1\u751f\u6c27\u5316\u635f\u4f24\u5e76\u9003\u9038\uff0c\u4ece\u800c\u6fc0\u6d3b\u56fa\u6709\u514d\u75ab\u4ee5\u5b9e\u73b0\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u7b56\u7565\u3002\u5177\u4f53\u800c\u8a00\uff0c\u6211\u4eec\u6784\u5efa\u4e86\u4e00\u79cd\u7eb3\u7c73\u50ac\u5316\u836f\u7269\uff0c\u540d\u4e3aMSN-Ru<sup>2+<\/sup>\/Fe<sup>2+<\/sup>\u7684\u8d1f\u8f7d\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u7c92\u5b50(MRF)\uff0c\u4ee5\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80demtDNA\u7684\u6c27\u5316\u635f\u4f24\u3002\u8fd9\u79cd\u6c27\u5316\u7684mtDNA\u80fd\u591f\u4ece\u80bf\u7624\u7ec6\u80de\u4e2d\u9003\u9038\uff0c\u5e76\u4f5c\u4e3a\u4e00\u79cd\u514d\u75ab\u539f\u6027\u635f\u4f24\u76f8\u5173\u7684\u5206\u5b50\u6a21\u5f0f(DAMPs)\u4f7f\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de(TAMs)\u53d1\u751fM1\u6781\u5316\uff0c\u5bfc\u81f4\u5de8\u566c\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u54cd\u5e94\u88ab\u91cd\u65b0\u6fc0\u6d3b\uff0c\u6700\u7ec8\u91ca\u653e\u5404\u79cd\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u6740\u6b7b\u5e76\u6e05\u9664\u80bf\u7624\u7ec6\u80de\u3002\u00a0\u6700\u91cd\u8981\u7684\u662f\uff0c\u57fa\u4e8e\u8c03\u8282TAMs\u5148\u5929\u514d\u75ab\u53cd\u5e94\u7684\u6cbb\u7597\u7b56\u7565\u4e0d\u4ec5\u963b\u6b62\u4e86\u539f\u53d1\u80bf\u7624\u7684\u8fdb\u5c55\uff0c\u800c\u4e14\u5728\u6cbb\u7597\u671f\u95f4\u51e0\u4e4e\u5b8c\u5168\u6291\u5236\u4e86\u8fdc\u5904\u80bf\u7624\u7684\u751f\u957f\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cNanocatalytic Innate Immunity Activation by Mitochondrial\u00a0DNA Oxidative Damage for Tumor-Specific Therapy\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728AM\u4e0a \u3002DOI: 10.1002\/adma.202008065<\/p>\n<p>\u56fe4\u00a0MRF\u7eb3\u7c73\u9897\u7c92\u7684\u5408\u6210\u548c\u5148\u5929\u514d\u75ab\u6cbb\u7597\u7b56\u7565<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224637\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-4-14.png\" alt=\"\" width=\"600\" height=\"623\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-4-14.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-4-14-289x300.png 289w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>J<\/b><\/strong><strong><b>ACS<\/b><\/strong><strong><b>\uff1a\u6e29\u548c\u78c1\u70ed\u6fc0\u6d3b\u56fa\u6709\u514d\u75ab\u7528\u4e8e\u809d\u764c\u6cbb\u7597<\/b><\/strong><\/p>\n<p>\u78c1\u6027\u70ed\u7597(MHT)\u662f\u4e00\u79cd\u65e0\u521b\u7684\u3001\u5bf9\u6df1\u90e8\u80bf\u7624\u5177\u6709\u826f\u597d\u7ec4\u7ec7\u7a7f\u900f\u6027\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4f46\u4e0d\u5e78\u7684\u662f\uff0c\u7531\u4e8e\u78c1\u70ed\u6548\u7387\u6709\u9650\uff0c\u5e38\u89c4\u9759\u8109\u6ce8\u5c04\u78c1\u6027\u7eb3\u7c73\u9897\u7c92\u5728\u80bf\u7624\u5185\u79ef\u7d2f\u4e0d\u8db3\uff0c\u5176\u6cbb\u7597\u6548\u679c\u8f83\u4f4e\u3002\u5b83\u4eec\u5b9e\u9645\u4e0a\u5927\u591a\u88ab\u5355\u6838\u541e\u566c\u7ec6\u80de\u7cfb\u7edf\u9694\u79bb\uff0c\u5c24\u5176\u662f\u809d\u810f\u3002<strong><b>\u4e2d\u79d1\u9662\u4e0a\u6d77\u7845\u9178\u76d0\u7814\u7a76\u6240\u80e1\u840d\u3001\u65bd\u5251\u6797\u9662\u58eb\u7b49\u4eba<\/b><\/strong>\u00a0\u9996\u6b21\u5229\u7528\u8fd9\u79cd\u809d\u810f\u4f18\u5148\u6444\u53d6\u7684\u4e0d\u5229\u7279\u70b9\uff0c\u5229\u7528\u7279\u6b8a\u8bbe\u8ba1\u7684\u590d\u5408\u78c1\u6027\u7eb3\u7c73\u9897\u7c92\uff0c\u5229\u7528\u8f7b\u5ea6MHT\u6cbb\u7597\u539f\u4f4d\u809d\u764c\u3002\u4e00\u79cd\u6838\u58f3\u7ed3\u6784\u7684\u3001Zn<sup>2+<\/sup>\u63ba\u6742\u7684<a href=\"mailto:Zn-CoFe2O4@Zn-MnFe2O4\">Zn-CoFe<sub>2<\/sub>O<sub>4<\/sub>@Zn-MnFe<sub>2<\/sub>O<sub>4<\/sub><\/a>\u8d85\u987a\u78c1\u6027\u7eb3\u7c73\u9897\u7c92\uff08ZCMF\uff09\uff0c\u7531\u4e8e\u8f6f\u786c\u78c1\u4e4b\u95f4\u7684\u4ea4\u6362\u8026\u5408\u4f5c\u7528\u3001Zn<sup>2+<\/sup>\u7684\u63ba\u6742\u548c\u5c3a\u5bf8\u7684\u589e\u5927\uff0c\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u3001\u9ad8\u5ea6\u53ef\u63a7\u7684\u78c1\u70ed\u6027\u80fd\u3002\u57fa\u4e8eZCMF\u768443 ~ 44\u2103\u53ef\u63a7\u7684\u8f7b\u5ea6MHT\u51e0\u4e4e\u5b8c\u5168\u6291\u5236\u809d\u764c\u7ec6\u80de\u589e\u6b96\u548c\u80bf\u7624\u751f\u957f\uff0c\u8fd9\u4e0e\u6291\u5236\u70ed\u4f11\u514b\u86cb\u767d70 (HSP70)\u7684\u8868\u8fbe\u6709\u5173\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u6e29\u548cMHT\u6cbb\u7597\u540e\u7684\u809d\u764c\u7ec6\u80de\u80fd\u591f\u901a\u8fc7\u663e\u8457\u4e0a\u8c03\u591a\u79cdUL16\u7ed3\u5408\u86cb\u767d\uff08ULBPs\uff09\u7684\u8868\u8fbe\u6765\u6fc0\u6d3bNK\u7ec6\u80de\uff0c\u56e0\u4e3aULBPs\u662fNK\u7ec6\u80de\u7684\u81ea\u7136\u6740\u4f24\u7ec6\u80de2\u65cf\u6210\u5458D\u53d7\u4f53\uff08NKG2D\uff09\u7684\u914d\u4f53\u3002\u56e0\u6b64\uff0c\u5728\u4f53\u5185\u901a\u8fc7\u8bf1\u5bfcNK\u7ec6\u80de\u76f8\u5173\u7684\u6297\u80bf\u7624\u514d\u75ab\uff0c\u8f7b\u5ea6MHT\u51e0\u4e4e\u5b8c\u5168\u6291\u5236\u4e86\u79fb\u690d\u7624\u548c\u539f\u4f4d\u809d\u80bf\u7624\u7684\u751f\u957f\u3002\u672c\u7814\u7a76\u4e0d\u4ec5\u8bc1\u660e\u4e86\u8f7b\u5ea6MHT\u6cbb\u7597\u809d\u764c\u7684\u5de8\u5927\u6f5c\u529b\uff0c\u800c\u4e14\u63ed\u793a\u4e86\u8f7b\u5ea6MHT\u6cbb\u7597\u809d\u764c\u7684\u6f5c\u5728\u514d\u75ab\u6fc0\u6d3b\u673a\u5236\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cMild Magnetic Hyperthermia-Activated Innate Immunity for Liver\u00a0Cancer Therapy\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728JACS\u4e0a\u3002DOI: 10.1021\/jacs.1c02537<\/p>\n<p>\u56fe5\u809d\u764c\u6cbb\u7597\u7684\u78c1\u6027\u589e\u5f3a\u3001\u8f7b\u5ea6\u78c1\u6027\u70ed\u7597\u548c\u6297\u80bf\u7624\u514d\u75ab\u8bf1\u5bfc\u539f\u7406\u56fe<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224638\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-5-13.png\" alt=\"\" width=\"600\" height=\"638\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-5-13.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-5-13-282x300.png 282w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>A<\/b><\/strong><strong><b>M<\/b><\/strong><strong><b>\uff1a\u6301\u4e45\u6027\u7a81\u89e6\u53ef\u5851\u6027\u7684\u591a\u6a21\u6001\u8c03\u8c10\u53d1\u5149\u8bb0\u5fc6\u4f53<\/b><\/strong><\/p>\n<p>\u6a21\u62df\u8bb0\u5fc6\u8fc7\u7a0b\uff0c\u5305\u62ec\u7f16\u7801\u3001\u5b58\u50a8\u548c\u68c0\u7d22\u4fe1\u606f\uff0c\u5bf9\u795e\u7ecf\u5f62\u6001\u8ba1\u7b97\u548c\u4eba\u5de5\u667a\u80fd\u81f3\u5173\u91cd\u8981\u3002\u901a\u8fc7\u57fa\u4e8e\u91d1\u5c5e\u6c27\u5316\u7269\u3001\u4e8c\u7ef4\u6750\u6599\u3001\u5206\u5b50\u590d\u5408\u7269\u548c\u76f8\u53d8\u6750\u6599\u7684\u7535\u5b50\u3001\u78c1\u6027\u6216\u5149\u5b50\u5668\u4ef6\u8fdb\u884c\u7a81\u89e6\u884c\u4e3a\u6a21\u62df\uff0c\u662f\u6267\u884c\u5177\u6709\u63d0\u9ad8\u529f\u7387\u6548\u7387\u7684\u8ba1\u7b97\u4efb\u52a1\u7684\u91cd\u8981\u7b56\u7565\u3002<strong><b>\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5218\u5c0f\u521a\u6559\u6388\u7b49\u4eba<\/b><\/strong>\u62a5\u9053\u4e86\u4e00\u79cd\u57fa\u4e8e\u6301\u4e45\u6027\u53d1\u5149\u8bb0\u5fc6\u4f53\u7684\u8bb0\u5fc6\u6750\u6599(\u79f0\u4e3a\u201c\u8bb0\u5fc6\u201d\u548c\u201c\u53d1\u5c04\u4f53\u201d\u7684\u7ec4\u5408)\uff0c\u5176\u5149\u5b66\u7279\u6027\u4e0e\u751f\u7269\u7a81\u89e6\u975e\u5e38\u76f8\u4f3c\u3002\u5728\u7cbe\u786e\u63a7\u5236\u6fc0\u53d1\u9891\u7387\u3001\u6ce2\u957f\u3001\u8109\u51b2\u6570\u548c\u529f\u7387\u5bc6\u5ea6\u7684\u6761\u4ef6\u4e0b\uff0c\u8bb0\u5fc6\u8fc7\u7a0b\u548c\u7a81\u89e6\u53ef\u5851\u6027\u53ef\u4ee5\u88ab\u6210\u529f\u5730\u6a21\u62df\u3002\u5b9e\u9a8c\u548c\u7406\u8bba\u6570\u636e\u8868\u660e\uff0c\u7535\u8026\u5408\u9677\u9631\u7684\u6210\u6838\u548c\u901a\u8fc7\u805a\u7c7b\u5728\u6301\u4e45\u6027\u53d1\u5149\u5206\u5b50\u4e2d\u4f20\u64ad\u53ef\u4ee5\u89e3\u91ca\u7ecf\u9a8c\u4f9d\u8d56\u7684\u53ef\u5851\u6027\u3002\u4f7f\u7528\u6301\u4e45\u6027\u53d1\u5149\u8bb0\u5fc6\u4f53\u591a\u901a\u9053\u56fe\u50cf\u8bb0\u5fc6\uff0c\u5141\u8bb8\u76f4\u63a5\u53ef\u89c6\u5316\u53d1\u5149\u5f3a\u5ea6\u7684\u5fae\u5999\u53d8\u5316\u548c\u5b9e\u73b0\u77ed\u671f\u548c\u957f\u671f\u8bb0\u5fc6\u4e5f\u88ab\u8bc1\u660e\u3002\u8fd9\u4e9b\u53d1\u73b0\u53ef\u80fd\u4fc3\u8fdb\u4eba\u5de5\u7a81\u89e6\u7b49\u65b0\u7684\u529f\u80fd\u6750\u6599\u7684\u53d1\u73b0\uff0c\u5e76\u52a0\u6df1\u5bf9\u8bb0\u5fc6\u673a\u5236\u7684\u7406\u89e3\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cMultimodal Tuning of Synaptic Plasticity Using Persistent\u00a0Luminescent Memitters\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728AM\u4e0a\u3002DOI: 10.1002\/adma.202101895<\/p>\n<p>\u56fe6\u6301\u4e45\u6027\u53d1\u5149\u8bb0\u5fc6\u4f53\u5b9e\u73b0\u751f\u7269\u6fc0\u53d1\u7684\u5168\u5149\u5b50\u7a81\u89e6<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224639\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-6-9.png\" alt=\"\" width=\"600\" height=\"376\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-6-9.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-6-9-300x188.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>C<\/b><\/strong><strong><b>hem\uff1a<\/b><\/strong><strong><b>\u8fc7\u6c27\u5316\u9499\u7eb3\u7c73\u9897\u7c92\u4ecb\u5bfc\u7684\u9499\u8d85\u8f7d\u80bf\u7624\u6cbb\u7597<\/b><\/strong><\/p>\n<p>\u9499\u8d85\u8f7d\uff0c\u4ee5\u6e38\u79bb\u9499\u79bb\u5b50(Ca<sup>2+<\/sup>)\u7684\u5f02\u5e38\u80de\u6d46\u79ef\u805a\u4e3a\u7279\u5f81\uff0c\u662f\u8bb8\u591a\u7ec6\u80de\u7c7b\u578b\u635f\u4f24\u751a\u81f3\u7ec6\u80de\u6b7b\u4ea1\u7684\u666e\u904d\u539f\u56e0\u3002\u8fd9\u79cd\u4e0d\u53d7\u6b22\u8fce\u7684\u7834\u574f\u6027\u8fc7\u7a0b\u53ef\u4ee5\u6210\u4e3a\u4e00\u79cd\u65b0\u7684\u5de5\u5177\uff0c\u9002\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u3002\u5728\u6b64\uff0c\u57fa\u4e8eCa<sup>2+<\/sup>\u72ec\u7279\u7684\u751f\u7269\u5b66\u6548\u5e94\uff0c<strong><b>\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5218\u5c0f\u521a\u6559\u6388\u7b49\u4eba<\/b><\/strong>\u5c55\u793a\u4e86\u4e00\u79cd\u5229\u7528pH\u654f\u611f\u7684\u900f\u660e\u8d28\u9178\u94a0\u4fee\u9970\u8fc7\u6c27\u5316\u9499\u7eb3\u7c73\u9897\u7c92(SH-CaO<sub>2<\/sub>\u00a0NPs)\u6cbb\u7597\u80bf\u7624\u7684\u9ad8\u6548\u7b56\u7565\u3002\u8fd9\u4e9bNPs\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u4ea7\u751f\u4e00\u79cd\u4eba\u5de5\u9499\u8d85\u8f7d\u538b\u529b\uff0c\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cNPs\u7684\u6740\u4f24\u4f5c\u7528\u5e76\u4e0d\u5c40\u9650\u4e8e\u80bf\u7624\u7c7b\u578b\u6216\u7f3a\u6c27\u7ec6\u80de\uff0c\u6b63\u5e38\u7ec6\u80de\u6bd4\u80bf\u7624\u7ec6\u80de\u66f4\u80fd\u8010\u53d7NPs\u7684\u4e0d\u826f\u5f71\u54cd\u3002Ca<sup>2+<\/sup>\u5bcc\u96c6\u4e5f\u589e\u52a0\u4e86\u80bf\u7624\u9499\u5316\u7684\u53ef\u80fd\u6027\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u4f53\u5185\u80bf\u7624\u6291\u5236\uff0c\u5e76\u4fc3\u8fdb\u533b\u5b66\u6210\u50cf\u76d1\u6d4b\u6cbb\u7597\u6548\u679c\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cCalcium-Overload-Mediated Tumor Therapy\u00a0by Calcium Peroxide Nanoparticles\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Chem\u4e0a\u3002DOI: 10.1016\/j.chempr.2019.06.003<\/p>\n<p>\u56fe7\u00a0SH-CaO<sub>2<\/sub>\u00a0NPs\u529f\u80fd\u6a21\u5f0f\u793a\u610f\u56fe<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224640\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-7-7.png\" alt=\"\" width=\"600\" height=\"543\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-7-7.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-7-7-300x272.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>AM<\/b><\/strong><strong><b>\uff1a<\/b><\/strong><strong><b>ATP\u54cd\u5e94\u667a\u80fd\u6c34\u51dd\u80f6\u91ca\u653e\u514d\u75ab\u4f50\u5242\uff0c\u4e0e\u91cd\u590d\u7684\u5316\u5b66\u7597\u6cd5\u6216\u653e\u7597\u540c\u6b65\uff0c\u4ee5\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u529b<\/b><\/strong><\/p>\n<p>\u67d0\u4e9b\u5316\u7597\u836f\u7269\u548c\u5f62\u5f0f\u7684\u7535\u79bb\u8f90\u5c04\u53ef\u8bf1\u53d1\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1(ICD)\u3002\u5982\u679c\u80bf\u7624\u4e2d\u540c\u65f6\u5b58\u5728\u514d\u75ab\u4f50\u5242\uff0c\u8fd9\u79cd\u6297\u80bf\u7624\u514d\u75ab\u5c06\u88ab\u8fdb\u4e00\u6b65\u653e\u5927\u3002\u7136\u800c\uff0c\u4e34\u5e8a\u5316\u7597\/\u653e\u7597\u901a\u5e38\u4ee5\u4f4e\u5242\u91cf\u91cd\u590d\u7ed9\u4e88\uff0c\u6bcf\u6b21\u5316\u7597\/\u653e\u7597\u65f6\u7ed9\u836f\u514d\u75ab\u4f50\u5242\u662f\u4e0d\u73b0\u5b9e\u7684\u3002\u00a0<strong><b>\u82cf\u5dde\u5927\u5b66\u5218\u5e84\u6559\u6388<\/b><\/strong><strong><b>\u7b49\u4eba<\/b><\/strong>\u5f00\u53d1\u4e86\u4e00\u79cd\u667a\u80fd\u6c34\u51dd\u80f6\uff0c\u53ef\u54cd\u5e94\u53cd\u590d\u5e94\u7528\u7684\u5316\u5b66\/\u653e\u5c04\u7597\u6cd5\u91ca\u653e\u514d\u75ab\u4f50\u5242\u3002\u6d77\u85fb\u9178\u4e0e\u4e09\u78f7\u9178\u817a\u82f7(ATP)\u7279\u5f02\u6027\u9002\u914d\u4f53\u7ed3\u5408\uff0c\u8be5\u9002\u914d\u4f53\u4e0e\u514d\u75ab\u4f50\u5242CpG\u5be1\u6838\u82f7\u9178\u6742\u4ea4\u3002\u7624\u5185\u6ce8\u5c04\u540e\uff0c\u5728\u539f\u4f4d\u5f62\u6210\u6d77\u85fb\u9178\u76d0\u57fa\u6c34\u51dd\u80f6\u3002\u6709\u8da3\u7684\u662f\uff0c\u4f4e\u5242\u91cf\u7684\u5965\u6c99\u5229\u94c2\u6216x\u5c04\u7ebf\u5728\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80deICD\u65f6\uff0c\u53ef\u89e6\u53d1ATP\u7684\u91ca\u653e\uff0cATP\u4e0eATP\u7279\u5f02\u6027\u9002\u914d\u4f53\u7ade\u4e89\u6027\u7ed3\u5408\uff0c\u89e6\u53d1CpG\u7684\u91ca\u653e\u3002\u56e0\u6b64\uff0c\u667a\u80fd\u6c34\u51dd\u80f6\u53ef\u5728\u4f4e\u5242\u91cf\u91cd\u590d\u5316\u7597\/\u653e\u7597\u7684\u540c\u65f6\u91ca\u653e\u514d\u75ab\u4f50\u5242\uff0c\u5728\u6d88\u9664\u5df2\u5efa\u7acb\u7684\u80bf\u7624\u65b9\u9762\u53d6\u5f97\u663e\u8457\u7684\u534f\u540c\u53cd\u5e94\uff0c\u5e76\u5177\u6709\u514d\u75ab\u8bb0\u5fc6\u6392\u65a5\u518d\u6b21\u653b\u51fb\u7684\u80bf\u7624\u3002\u6b64\u5916\uff0c\u667a\u80fd\u6c34\u51dd\u80f6\u8f85\u52a9\u91cd\u590d\u653e\u7597\u53ef\u6291\u5236\u8fdc\u5904\u80bf\u7624\u8f6c\u79fb\uff0c\u7279\u522b\u662f\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u5c01\u9501\u3002\u8be5\u7814\u7a76\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u7684\u6982\u5ff5\u7b56\u7565\uff0c\u4ee5\u4fc3\u8fdb\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e00\u81f4\u7684\u91cd\u590d\u4f4e\u5242\u91cf\u5316\u7597\/\u653e\u7597\u4e34\u5e8a\u76f8\u5173\u7684\u65b9\u5f0f\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cATP-Responsive Smart Hydrogel Releasing Immune\u00a0Adjuvant Synchronized with Repeated Chemotherapy or\u00a0Radiotherapy to Boost Antitumor Immunity\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728AM\u4e0a\u3002DOI: 10.1002\/adma.202007910<\/p>\n<p>\u56fe8\u00a0\u6784\u5efa\u667a\u80fd\u6c34\u51dd\u80f6\uff0cATP\u91ca\u653eCpG<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224641\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-8-6.png\" alt=\"\" width=\"600\" height=\"487\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-8-6.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-8-6-300x244.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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Logic Computing Reaction on Living Cells to Enable\u00a0Non-Antibody Immune Checkpoint Blockade Therapy\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728JACS\u4e0a\u3002DOI: 10.1021\/jacs.1c02016<\/p>\n<p>\u56fe9\u00a0\u5229\u7528D-sgc8\u9002\u914d\u4f53\u6784\u5efa\u6d3b\u7ec6\u80de\u8868\u9762\u903b\u8f91\u7535\u8def<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224642\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-9-4.png\" alt=\"\" width=\"600\" height=\"582\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-9-4.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/07\/\u56fe\u7247-9-4-300x291.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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