{"id":224005,"date":"2021-06-30T06:11:15","date_gmt":"2021-06-29T22:11:15","guid":{"rendered":"\/\/m.iemloyee.com\/?p=224005"},"modified":"2021-06-29T22:11:29","modified_gmt":"2021-06-29T14:11:29","slug":"%e9%a6%99%e6%b8%af%e7%a7%91%e6%8a%80%e5%a4%a7%e5%ad%a6%e5%94%90%e6%9c%ac%e5%bf%a0%e5%8d%a1%e7%bd%97%e6%9e%97%e6%96%af%e5%8d%a1%e5%ad%a6%e9%99%a2duo-yanhong%e9%80%9a%e8%bf%87%e4%bb%8b%e5%85%a5","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=224005","title":{"rendered":"\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u5510\u672c\u5fe0&\u5361\u7f57\u6797\u65af\u5361\u5b66\u9662Duo Yanhong:\u901a\u8fc7\u4ecb\u5165\u65b9\u6cd5\u5bf9\u539f\u4f4d\u7ed3\u80a0\u80bf\u7624\u8fdb\u884c\u8010\u7f3a\u6c27\u5149\u52a8\u529b\u6cbb\u7597\u7684\u4eae\u83cc"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u4e0e\u4f5c\u4e3a\u5355\u4f53\u5b58\u5728\u65f6\u76f8\u6bd4\uff0c\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\uff08AIE\uff09\u6d3b\u6027\u8367\u5149\u56e2\u5728\u805a\u96c6\u65f6\u8868\u73b0\u51fa\u663e\u7740\u589e\u5f3a\u7684\u53d1\u5c04\u7387\u3002\u7531\u4e8e\u5176\u9ad8\u751f\u7269\u76f8\u5bb9\u6027\u3001\u9ad8\u5149\u7a33\u5b9a\u6027\u4ee5\u53ca\u4e0e\u9ad8\u5bf9\u6bd4\u5ea6\u6210\u50cf\u7b56\u7565\u7684\u517c\u5bb9\u6027\uff0cAIE \u53d1\u5149\u539f (AIEgens) \u662f\u4e00\u79cd\u7406\u60f3\u7684\u751f\u7269\u6210\u50cf\u5de5\u5177\u3002 AIEgens \u8fd8\u901a\u8fc7\u5149\u52a8\u529b\u7597\u6cd5 (PDT) \u65b9\u6cd5\u7528\u4e8e\u975e\u4fb5\u5165\u6027\u764c\u75c7\u6cbb\u7597\uff0c\u56e0\u4e3a\u5b83\u4eec\u53ef\u4ee5\u4f5c\u4e3a\u54cd\u5e94\u5149\u4ea7\u751f\u6d3b\u6027\u6c27 (ROS) \u7684\u6765\u6e90\u3002\u867d\u7136\u4ee5\u5355\u4f53\u5f62\u5f0f\u53d1\u5c04\uff0c\u4f46\u7531\u4e8e\u5206\u5b50\u5185\u8fd0\u52a8\u548c\u76f8\u5173\u8f90\u5c04\u8870\u51cf\u7684\u9650\u5236\uff0c\u8fd9\u4e9b AIEgen \u5728\u805a\u96c6\u65f6\u8868\u73b0\u51fa\u5f3a\u70c8\u7684\u7167\u660e\u3002\u805a\u96c6\u540e\u5bf9\u975e\u8f90\u5c04 AIEgen \u7684\u6709\u6548\u6291\u5236\u53ef\u4ee5\u4fc3\u8fdb\u751f\u7269\u6210\u50cf\uff0c\u8fd8\u53ef\u4ee5\u63d0\u9ad8\u4e09\u91cd\u6001\u6fc0\u5b50\u7684\u7a33\u5b9a\u6027\uff0c\u4ece\u800c\u63a8\u52a8\u7a33\u5065\u7684 ROS \u751f\u6210\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5df2\u7ecf\u5f00\u53d1\u4e86\u51e0\u79cd\u4e0d\u540c\u7684\u65b9\u6cd5\u6765\u5229\u7528 AIEgens \u8fdb\u884c\u9776\u5411\u80bf\u7624 PDT\u3002\u7136\u800c\uff0c\u4f7f\u7528 AIEgens \u7684\u80bf\u7624\u6cbb\u7597\u4ecd\u7136\u53d7\u5230\u8bb8\u591a\u56e0\u7d20\u7684\u9650\u5236\u3002\u4e00\u65b9\u9762\uff0c\u6fc0\u5149\u7a7f\u900f\u6df1\u5ea6\u6709\u9650\uff0c\u65e0\u6cd5\u4f7f\u7528 PDT \u6cbb\u7597\u6df1\u90e8\u80bf\u7624\u5e76\u5f71\u54cd\u809d\u810f\u6216\u7ed3\u80a0\u7b49\u7ec4\u7ec7\u3002\u6b64\u5916\uff0c\u80bf\u7624\u5fae\u73af\u5883\u5185\u7684\u7f3a\u6c27\u4f1a\u9650\u5236PDT\u7684\u7597\u6548\uff0c\u5f88\u5c11\u6709\u7814\u7a76\u8bc1\u660ePDT\u6cbb\u7597\u7f3a\u6c27\u80bf\u7624\u7ec4\u7ec7\u662f\u6210\u529f\u7684\u3002\u56e0\u6b64\uff0c\u663e\u7136\u9700\u8981\u5f00\u53d1\u66f4\u591a\u7684\u57fa\u4e8e\u00a0AIEgens \u7684\u80bf\u7624\u6cbb\u7597\u5e73\u53f0\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u867d\u7136\u5f88\u6709\u524d\u666f\uff0c\u4f46\u57fa\u4e8e\u805a\u96c6\u8bf1\u5bfc\u53d1\u5c04 (AIE) \u7684\u5149\u52a8\u529b\u7597\u6cd5 (PDT) \u7684\u529f\u6548\u53d7\u5230\u591a\u79cd\u56e0\u7d20\u7684\u9650\u5236\uff0c\u5305\u62ec\u6fc0\u5149\u7a7f\u900f\u6df1\u5ea6\u6709\u9650\u548c\u7624\u5185\u7f3a\u6c27\u3002\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u5510\u672c\u5fe0&\u5361\u7f57\u6797\u65af\u5361\u5b66\u9662Duo Yanhong<\/b><\/strong>\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u7684\u57fa\u4e8e\u7ec6\u83cc\u7684 AIEgen (TBP-2) \u6df7\u5408\u7cfb\u7edf (AE)\uff0c\u80fd\u591f\u901a\u8fc7\u4ecb\u5165\u65b9\u6cd5\u4fc3\u8fdb\u539f\u4f4d\u7ed3\u80a0\u80bf\u7624\u7684\u8010\u7f3a\u6c27 PDT \u6cbb\u7597\u3002\u5bf9\u4e8e\u8fd9\u79cd\u65b9\u6cd5\uff0c\u6700\u521d\u8bbe\u8ba1\u4e86\u4e00\u79cd\u4ecb\u5165\u88c5\u7f6e\uff0c\u7531\u5149\u7ea4\u548c\u5185\u7aa5\u955c\u7ec4\u6210\uff0c\u53ef\u4ee5\u6e05\u6670\u5730\u663e\u793a\u8179\u8154\u5185\u539f\u4f4d\u80bf\u7624\u7684\u4f4d\u7f6e\u3002\u7136\u540e\u6709\u53ef\u80fd\u901a\u8fc7\u6fc0\u5149\u7167\u5c04\u5bf9\u8fd9\u79cd\u7f3a\u6c27\u80bf\u7624\u8fdb\u884c\u6210\u529f\u7684 PDT \u6cbb\u7597\uff0c\u56e0\u4e3a TBP-2 \u80fd\u591f\u901a\u8fc7\u8fd9\u79cd\u7f3a\u6c27\u5fae\u73af\u5883\u4e2d\u7684 I \u578b\u673a\u5236\u4ea7\u751f\u7f9f\u57fa\u81ea\u7531\u57fa (\u2022OH)\u3002\u6b64\u5916\uff0c\u8fd9\u79cd\u4ecb\u5165\u65b9\u6cd5\u88ab\u8bc1\u660e\u53ef\u4ee5\u663e\u7740\u635f\u5bb3\u539f\u4f4d\u7ed3\u80a0\u764c\u7684\u751f\u957f\u5e76\u514b\u670d PDT \u7f3a\u9677\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201c<\/b><\/strong>Bright Bacterium for Hypoxia-Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method<\/b><\/strong>\u201d<\/b><\/strong>\u53d1\u8868\u5728Adv<\/b><\/strong>. <\/b><\/strong>Sci.<\/b><\/strong>\u4e0a<\/b><\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe<\/b><\/strong>1.<\/b><\/strong>\u7ec6\u83cc\u7684\u6210\u50cf\u4e0e\u6cbb\u7597<\/b><\/strong><\/p>\n

\"\"<\/p>\n

A-B)\u5927\u80a0\u6746\u83cc\u548c AE \u7684 TEM \u56fe\u50cf<\/p>\n

C)AE \u7684\u8367\u5149\u56fe\u50cf\uff0c\u8868\u660e TBP-2 \u6210\u529f\u52a0\u8f7d\u5230\u8fd9\u4e9b\u7ec6\u83cc\u4e2d<\/p>\n

D)\u5927\u80a0\u6746\u83cc\u3001AE \u548c TBP-2 \u7684\u5438\u6536\u5149\u8c31<\/p>\n

E)\u4e0d\u540c\u5927\u80a0\u6746\u83cc\u7fa4\u4f53\u4e2d\u7684 TBP-2 \u6c34\u5e73<\/p>\n

F)TBP-2 \u4ecb\u5bfc\u7684 \u2022OH \u751f\u6210\uff0c\u901a\u8fc7 ESR \u4f7f\u7528\/\u4e0d\u4f7f\u7528\u767d\u8272\u6fc0\u5149\u6fc0\u53d1<\/p>\n

G)\u5728 WL \u6fc0\u53d1\u4e0b\u4e0e\u6307\u5b9a\u914d\u65b9\u76f8\u5173\u7684 1O2 \u751f\u6210\u5f15\u8d77\u7684 ABDA \u5206\u89e3\u901f\u7387<\/p>\n

H)\u5728 WL \u6fc0\u53d1\u4e0b\u7531\u4e0e\u6307\u5b9a\u914d\u65b9\u76f8\u5173\u7684 \u2022OH \u751f\u6210\u5f15\u8d77\u7684 TA \u5206\u89e3\u901f\u7387<\/p>\n

I)\u4e0d\u540c\u5149\u7167\u6761\u4ef6\u4e0bTBP-2\u5bf9\u5927\u80a0\u6746\u83cc\u7684\u6291\u83cc\u6548\u679c\u8bc4\u4ef7<\/p>\n

\u56fe<\/b><\/strong>2.<\/b><\/strong>\u7ec6\u80de\u7684\u6cbb\u7597<\/b><\/strong><\/p>\n

\"\"<\/p>\n

A)\u6307\u5b9a\u6cbb\u7597\u540e\u7684 CT26 \u7ec6\u80de\u8367\u5149\u56fe\u50cf<\/p>\n

B)\u5728\u5e38\u6c27\u6216\u7f3a\u6c27\u6761\u4ef6\u4e0b\u8fdb\u884c\u6307\u5b9a\u5904\u7406\u540e\u89c2\u5bdf\u80bf\u7624\u7ec6\u80de DCFH-DA \u8367\u5149\u56fe\u50cf<\/p>\n

C-D)\u5728\u5e38\u6c27\u6216\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0c\u7528\u4e0d\u540c TBP-2 \u6d53\u5ea6\u7684 PBS\u3001L\u3001AE \u6216 AE+L \u5904\u7406\u7684 CT26 \u80bf\u7624\u7ec6\u80de\u7684\u6d3b\u529b<\/p>\n

\u56fe3.<\/b><\/strong>\u4f53\u5185\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

A-B)\u5728 AE \u6216 AP \u6ce8\u5c04\u540e 24 \u5c0f\u65f6\uff0c\u643a\u5e26\u539f\u4f4d CT26 \u80bf\u7624\u7684\u5c0f\u9f20\u4f53\u5185\u6536\u96c6\u7684\u80bf\u7624\u7ec4\u7ec7\u548c\u5668\u5b98\u7684\u79bb\u4f53\u56fe\u50cf\u548c\u8f90\u5c04\u6548\u7387<\/p>\n

C)AE \u4e0e\u7f3a\u6c27\u533a\u57df\u5171\u5b9a\u4f4d\u7684\u8367\u5149\u53ef\u89c6\u5316<\/p>\n

D)\u56fe 3C \u4e2d\u6807\u8bb0\u7684\u7f3a\u6c27\u533a\u57df\u5185\u6cbf\u7ea2\u7ebf\u7684 PIMO \u548c TBP-2 \u8367\u5149\u5206\u5e03\u66f2\u7ebf<\/p>\n

\u56fe<\/b><\/strong>4<\/b><\/strong>.<\/b><\/strong>\u5c0f\u9f20\u7684\u4f53\u5185\u6cbb\u7597<\/b><\/strong><\/p>\n

\"\"<\/p>\n

A)\u5f00\u53d1\u7531\u5185\u7aa5\u955c\u548c\u5149\u7ea4\u7ec4\u6210\u7684\u4ecb\u5165\u88c5\u7f6e<\/p>\n

B)\u643a\u5e26\u539f\u4f4d CT26 \u80bf\u7624\u7684\u5c0f\u9f20\u8fdb\u884c\u4ecb\u5165\u6027 PDT \u7684\u56fe\u50cf<\/p>\n

C)\u8179\u8154\u5185\u539f\u4f4d\u80bf\u7624\u4f4d\u7f6e\uff0c\u5982\u901a\u8fc7\u5185\u7aa5\u955c\u89c2\u5bdf<\/p>\n

D)\u6307\u5b9a\u6cbb\u7597\u7ec4\u4e2d\u5207\u9664\u7684\u539f\u4f4d CT26 \u80bf\u7624\u7684\u56fe\u50cf<\/p>\n

E-F)\u5728\u643a\u5e26\u539f\u4f4d CT26 \u80bf\u7624\u7684\u5c0f\u9f20\u4e2d\u8fdb\u884c\u6307\u5b9a\u6cbb\u7597\u540e\u7684\u80bf\u7624\u4f53\u79ef\u548c\u4f53\u91cd\u66f2\u7ebf<\/p>\n

G)\u6765\u81ea\u6307\u5b9a\u6cbb\u7597\u7ec4\u5c0f\u9f20\u7684\u4ee3\u8868\u6027 TUNEL \u548c Ki-67 \u67d3\u8272\u80bf\u7624\u5207\u7247<\/p>\n

\u3010<\/b><\/strong>\u5c0f\u7ed3<\/b><\/strong>\u3011<\/b><\/strong><\/p>\n

\u8fd9\u4e2a\u5de5\u4f5c\u8bbe\u8ba1\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u57fa\u4e8e\u7ec6\u83cc\u7684\u6df7\u5408 AIEgen \u7cfb\u7edf\uff0c\u8be5\u7cfb\u7edf\u80fd\u591f\u901a\u8fc7\u4ecb\u5165\u65b9\u6cd5\u4fc3\u8fdb\u539f\u4f4d\u7ed3\u80a0\u80bf\u7624\u7684\u8010\u7f3a\u6c27 PDT \u6cbb\u7597\u3002\u8fd9\u79cd\u9488\u5bf9\u7f3a\u6c27\u7684 AE \u7528\u4e8e\u5c06 TBP-2 \u7279\u5f02\u6027\u9012\u9001\u5230\u80bf\u7624\u5185\u7684\u7f3a\u6c27\u533a\u57df\uff0c\u7136\u540e\u4f7f\u7528\u65b0\u578b\u4ecb\u5165\u6cbb\u7597\u7cfb\u7edf\u8fdb\u884c\u6fc0\u5149\u7167\u5c04\u4ecb\u5bfc\u7684 PDT\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u80bf\u7624\u5185\u7684 TBP-2 \u80fd\u591f\u4f5c\u4e3a PS \u5e76\u56e0\u6b64\u5728\u54cd\u5e94\u6fc0\u5149\u7167\u5c04\u7684\u7f3a\u6c27\u6761\u4ef6\u4e0b\u901a\u8fc7 I \u578b\u673a\u5236\u4ea7\u751f \u2022OH\u3002\u8fd9\u79cd\u65b9\u6cd5\u8db3\u4ee5\u6291\u5236\u539f\u4f4d\u7ed3\u80a0\u80bf\u7624\u7684\u751f\u957f\u5e76\u514b\u670d\u4e0e PDT \u76f8\u5173\u7684\u8bb8\u591a\u9650\u5236\u3002\u8fd9\u4e5f\u662f\u7b2c\u4e00\u9879\u91c7\u7528\u4ecb\u5165\u5f0f PDT \u6cbb\u7597\u6df1\u90e8\u80bf\u7624\u7684\u7814\u7a76\uff0c\u8fd9\u4e2a\u65b9\u6cd5\u53ef\u4ee5\u4f5c\u4e3a\u5176\u4ed6\u6cbb\u7597\u65b9\u5f0f\u7684\u8865\u5145\u63d0\u4f9b\u4ef7\u503c\uff0c\u4e3a\u5f00\u53d1\u989d\u5916\u7684\u6df7\u5408 AIEgen \u7cfb\u7edf\u63d0\u4f9b\u65b0\u7684\u9014\u5f84\u3002\u672a\u6765\uff0c\u4f5c\u8005\u5c06\u7ee7\u7eed\u8bbe\u8ba1\u66f4\u5148\u8fdb\u7684\u57fa\u4e8e AIEgen \u7684\u7cfb\u7edf\uff0c\u4ee5\u66f4\u597d\u5730\u63d0\u9ad8\u8fd9\u4e9b AIEgen \u7684\u4e34\u5e8a\u5b9e\u7528\u6027\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/b><\/strong>\uff1aBright Bacterium for Hypoxia-Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method. Adv<\/b><\/strong>. <\/b><\/strong>Sci<\/b><\/strong>.<\/b><\/strong>, <\/i><\/em>202<\/b><\/strong>1<\/b><\/strong>, DOI:10.1002\/advs.202004769<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4tt\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

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