{"id":223998,"date":"2021-06-30T12:00:40","date_gmt":"2021-06-30T04:00:40","guid":{"rendered":"\/\/m.iemloyee.com\/?p=223998"},"modified":"2021-06-30T18:23:19","modified_gmt":"2021-06-30T10:23:19","slug":"%e3%80%90oa%e3%80%91%e5%8d%97%e4%ba%ac%e5%a4%a7%e5%ad%a6%e6%9c%b1%e5%b0%91%e6%9e%97%e7%ad%89%e4%ba%banat-commun-%e9%95%8d%e5%82%ac%e5%8c%96%e7%9a%84%e7%83%af%e7%83%83%e4%b8%8e%e6%ba%b4%e7%82%94","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=223998","title":{"rendered":"\u5357\u4eac\u5927\u5b66\u6731\u5c11\u6797\u7b49\u4ebaNat. Commun.:\u954d\u50ac\u5316\u7684\u70ef\u70c3\u4e0e\u6eb4\u7094\u70c3\u7684\u8fc1\u79fb\u52a0\u6c22\u7094\u57fa\u5316\u548c\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6c22\u7094\u57fa\u5316"},"content":{"rendered":"<p>\u3010<strong><b>\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n<p>\u4f5c\u4e3a\u5173\u952e\u7684\u7ed3\u6784\u5143\u7d20\uff0c\u5177\u6709\u03b1-\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u7094\u70c3\u57fa\u5e8f\u7ecf\u5e38\u5b58\u5728\u4e8e\u8bb8\u591a\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u3001\u5316\u5b66\u63a2\u9488\u548c\u529f\u80fd\u6750\u6599\u4e2d\u3002\u6b64\u5916\uff0c\u5b83\u4eec\u4e5f\u662f\u6709\u4ef7\u503c\u7684\u5408\u6210\u5b50\uff0c\u56e0\u4e3a sp3 \u6742\u5316\u78b3\u53ef\u4ee5\u8fdb\u884c\u591a\u79cd\u8f6c\u5316\u4ee5\u63d0\u4f9b\u6709\u7528\u7684 sp2 \u6216 sp3 \u6742\u5316\u78b3\u3002\u79d1\u5b66\u5bb6\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u5728\u5bfb\u627e\u6709\u6548\u7684\u50ac\u5316\u3001\u5bf9\u6620\u9009\u62e9\u6027 C(sp3)-C(sp) \u5076\u8054\u4ee5\u4ea7\u751f\u8fd9\u79cd\u7acb\u4f53\u4e2d\u5fc3\u7684\u7b56\u7565\u3002\u4f8b\u5982\uff0cLiu\u62a5\u9053\u4e86\u4e00\u9879\u5173\u4e8e\u94dc\u50ac\u5316\u4e0d\u5bf9\u79f0 Sonogashira C(sp3)\u2013C(sp) \u8026\u5408\u7684\u51fa\u8272\u5de5\u4f5c\u3002 Shi \u548c Liu \u5df2\u7ecf\u8bc1\u660e Pd \u548c Cu \u50ac\u5316\u7684 C(sp3)-H \u7094\u57fa\u5316\u53ef\u4ee5\u4ee5\u5bf9\u6620\u9009\u62e9\u6027\u65b9\u5f0f\u5b9e\u73b0\u3002Liu \u8fd8\u4f7f\u7528\u70ef\u70c3\u53cc\u5b98\u80fd\u5316\u7b56\u7565\u5728\u94dc\u50ac\u5316\u5242\u4e0b\u751f\u4ea7\u5bf9\u6620\u4f53\u5bcc\u96c6\u7684\u7094\u57fa\u5316\u4ea7\u7269\u3002Suginome \u62a5\u544a\u4e86\u57fa\u4e8e\u5176\u5148\u524d\u52a0\u6c22\u7094\u5316\u5de5\u4f5c\u7684\u954d\u50ac\u5316 1,3-\u4e8c\u70ef\u4e0d\u5bf9\u79f0\u52a0\u6c22\u7094\u5316\u7684\u5f00\u521b\u6027\u5de5\u4f5c\u3002\u4f5c\u4e3a\u4e0d\u5bf9\u79f0 C(sp3)-C(sp) \u5076\u8054\u7684\u901a\u7528\u66ff\u4ee3\u65b9\u6848\u7684\u6301\u7eed\u53d1\u5c55\u4f9d\u7136\u83b7\u5f97\u4e86\u79d1\u7814\u754c\u7684\u5de8\u5927\u5173\u6ce8\u3002<\/p>\n<p>\u3010<strong><b>\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n<p>\u03b1-\u624b\u6027\u7094\u70c3\u662f\u8bb8\u591a\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u3001\u5316\u5b66\u63a2\u9488\u548c\u529f\u80fd\u6750\u6599\u7684\u5173\u952e\u7ed3\u6784\u5143\u7d20\u3002<strong><b>\u5357\u4eac\u5927\u5b66\u6731\u5c11\u6797\u548cWang You<\/b><\/strong>\u62a5\u544a\u4e86\u4e00\u79cd NiH \u50ac\u5316\u7684\u70ef\u70c3\u4e0e\u6eb4\u7094\u70c3\u7684\u8fd8\u539f\u8fc1\u79fb\u52a0\u6c22\u7094\u57fa\u5316\u53cd\u5e94\uff0c\u8be5\u53cd\u5e94\u4ee5\u9ad8\u4ea7\u7387\u548c\u4f18\u5f02\u7684\u533a\u57df\u9009\u62e9\u6027\u63d0\u4f9b\u76f8\u5e94\u7684\u82c4\u57fa\u7094\u57fa\u5316\u4ea7\u7269\u3002\u4f7f\u7528\u7b80\u5355\u7684\u624b\u6027 PyrOx \u914d\u4f53\u4e5f\u5b9e\u73b0\u4e86\u82ef\u4e59\u70ef\u7684\u50ac\u5316\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6c22\u7094\u5316\u3002\u83b7\u5f97\u7684\u5bf9\u6620\u4f53\u5bcc\u96c6\u7684\u82c4\u57fa\u7094\u70c3\u662f\u901a\u7528\u7684\u5408\u6210\u4e2d\u95f4\u4f53\uff0c\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u8f6c\u5316\u4e3a\u5408\u6210\u6709\u7528\u7684\u624b\u6027\u5408\u6210\u5b50\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a<strong><b>\u201c<\/b><\/strong><strong><b>Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes<\/b><\/strong><strong><b>\u201d<\/b><\/strong>\u53d1\u8868\u5728<strong><b>Nat. <\/b><\/strong><strong><b>Commun.<\/b><\/strong><strong><b>\u4e0a<\/b><\/strong>\u3002<\/p>\n<p><strong><b>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n<p><strong><b>\u56fe<\/b><\/strong><strong><b>1.Ni(I)H \u50ac\u5316\u7684\u8fc1\u79fb\u52a0\u6c22\u7094\u57fa\u5316\u548c\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6c22\u7094\u57fa\u5316<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-223999\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r1-7.jpg\" alt=\"\" width=\"600\" height=\"1194\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r1-7.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r1-7-151x300.jpg 151w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r1-7-515x1024.jpg 515w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>(a) \u5e26\u6709\u624b\u6027\u7094\u70c3\u57fa\u5e8f\u7684\u4ee3\u8868\u6027\u751f\u7269\u6d3b\u6027\u5206\u5b50<\/p>\n<p>(b) C(sp3)\u2013C(sp) \u8026\u5408\u7684\u5e38\u7528\u7b56\u7565<\/p>\n<p>(c) \u5316\u5b66\u548c\u7acb\u4f53\u9009\u62e9\u6027 NiH \u50ac\u5316\uff08\u8fc1\u79fb\uff09\u70ef\u70c3\u7684\u52a0\u6c22\u7094\u5316<\/p>\n<p><strong><b>\u56fe<\/b><\/strong><strong><b>2.<\/b><\/strong><strong><b>\u53cd\u5e94\u53c2\u6570\u7684\u53d8\u5316<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224000\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r2-9.jpg\" alt=\"\" width=\"600\" height=\"554\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r2-9.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r2-9-300x277.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>\u56fe3.NiH \u50ac\u5316\u70ef\u70c3\u4e0e\u6eb4\u7094\u7684\u8fc1\u79fb\u52a0\u6c22\u7094\u5316<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224001\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r3-7.jpg\" alt=\"\" width=\"600\" height=\"539\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r3-7.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r3-7-300x270.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>\u56fe<\/b><\/strong><strong><b>4<\/b><\/strong><strong><b>.NiH \u50ac\u5316\u82ef\u4e59\u70ef\u4e0e\u6eb4\u7094\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6c22\u7094\u5316<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224002\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r4-7.jpg\" alt=\"\" width=\"600\" height=\"550\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r4-7.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r4-7-300x275.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>\u56fe<\/b><\/strong><strong><b>5<\/b><\/strong><strong><b>.\u5bf9\u6620\u9009\u62e9\u6027\u8fc1\u79fb\u6c22\u7094\u5316\u3001\u514b\u7ea7\u3001\u884d\u751f\u5316\u548c\u540c\u4f4d\u7d20\u6807\u8bb0\u5b9e\u9a8c<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-224003\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r5-3.jpg\" alt=\"\" width=\"600\" height=\"334\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r5-3.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/06\/r5-3-300x167.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>(a) \u5bf9\u6620\u9009\u62e9\u6027\u8fc1\u79fb\u6c22\u7094\u5316\u7684\u521d\u6b65\u7ed3\u679c<\/p>\n<p>(b) \u514b\u7ea7\u5b9e\u9a8c<\/p>\n<p>(c) \u5bf9\u6620\u4f53\u5bcc\u96c6\u7684\u82c4\u57fa\u7094\u70c3\u7684\u8f6c\u5316<\/p>\n<p>(d) \u540c\u4f4d\u7d20\u6807\u8bb0\u5b9e\u9a8c<\/p>\n<p>(e) \u4ea4\u53c9\u5b9e\u9a8c<\/p>\n<p><strong><b>\u3010<\/b><\/strong><strong><b>\u5c0f\u7ed3<\/b><\/strong><strong><b>\u3011<\/b><\/strong><\/p>\n<p>\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u62a5\u9053\u4e86\u4e00\u79cd NiH \u50ac\u5316\u7684\u7b56\u7565\uff0c\u4ee5\u5f62\u6210\u529f\u80fd\u5316\u7684\u82c4\u57fa\u7094\u57fa\u5316\u4ea7\u7269\uff0c\u8fd9\u662f\u4e00\u79cd\u901a\u7528\u7684\u5408\u6210\u4e2d\u95f4\u4f53\u3002\u53ef\u4ee5\u5b9e\u73b0\u8fc1\u79fb\u52a0\u6c22\u7094\u5316\u548c\u4e0d\u5bf9\u79f0\u52a0\u6c22\u7094\u5316\u3002\u8fd9\u4e24\u79cd\u6e29\u548c\u3001\u9ad8\u6548\u4e14\u76f4\u63a5\u7684\u8fc7\u7a0b\u53ef\u4ee5\u5728\u70ef\u70c3\u548c\u6eb4\u7094\u7ec4\u5206\u4e0a\u8010\u53d7\u5e7f\u6cdb\u7684\u5b98\u80fd\u56e2\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u5bf9\u8be5\u8f6c\u53d8\u7684\u8fc1\u79fb\u5bf9\u6620\u9009\u62e9\u6027\u7248\u672c\u7684\u673a\u5236\u7814\u7a76\u3002<\/p>\n<p><strong><b>\u6587\u732e\u94fe\u63a5<\/b><\/strong>\uff1aNickel-catalysed migratory hydroalkynylation and\u00a0enantioselective hydroalkynylation of olefins with bromoalkynes. <strong><b>Nat. <\/b><\/strong><strong><b>Commun<\/b><\/strong><strong><b>.<\/b><\/strong><em><i>, <\/i><\/em><strong><b>202<\/b><\/strong><strong><b>1<\/b><\/strong>, DOI:10.1038\/s41467-021-24094-9<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4tt\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u4f5c\u4e3a\u5173\u952e\u7684\u7ed3\u6784\u5143\u7d20\uff0c\u5177\u6709\u03b1-\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u7094\u70c3\u57fa\u5e8f\u7ecf\u5e38\u5b58\u5728\u4e8e\u8bb8\u591a\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u3001\u5316\u5b66\u63a2\u9488\u548c\u529f\u80fd\u6750\u6599\u4e2d\u3002\u6b64\u5916\uff0c\u5b83\u4eec\u4e5f\u662f\u6709\u4ef7\u503c\u7684\u5408\u6210\u5b50\uff0c\u56e0\u4e3a sp3 \u6742\u5316&#8230;<\/p>\n","protected":false},"author":7336,"featured_media":223999,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[2490],"class_list":["post-223998","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-2490"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/223998"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=223998"}],"version-history":[{"count":3,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/223998\/revisions"}],"predecessor-version":[{"id":224113,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/223998\/revisions\/224113"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/223999"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=223998"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=223998"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=223998"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}