{"id":223086,"date":"2021-06-14T06:28:10","date_gmt":"2021-06-13T22:28:10","guid":{"rendered":"\/\/m.iemloyee.com\/?p=223086"},"modified":"2021-06-13T20:28:23","modified_gmt":"2021-06-13T12:28:23","slug":"%e5%b7%b4%e6%96%af%e5%a4%a7%e5%ad%a6tony-james%e5%8d%97%e6%b4%8b%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6%e6%b5%a6%e4%be%83%e8%a3%94nat-rev-chem-%e7%94%a8%e4%ba%8e%e4%bc%a0%e6%84%9f%e5%92%8c%e6%b2%bb","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=223086","title":{"rendered":"\u5df4\u65af\u5927\u5b66Tony James&\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u6d66\u4f83\u88d4Nat. Rev. Chem.:\u7528\u4e8e\u4f20\u611f\u548c\u6cbb\u7597\u7684\u53cc\u9501\u5149\u5b66\u63a2\u9488"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u5149\u5b66\u6210\u50cf\u80fd\u591f\u4ee5\u9ad8\u65f6\u7a7a\u5206\u8fa8\u7387\u548c\u9ad8\u7075\u654f\u5ea6\u5b9e\u65f6\u3001\u975e\u4fb5\u5165\u6027\u5730\u68c0\u6d4b\u7ec6\u80de\u3001\u7ec4\u7ec7\u751a\u81f3\u6574\u4e2a\u751f\u7269\u4f53\u4e2d\u751f\u7269\u5206\u5b50\u7684\u5b9a\u4f4d\u3001\u8fd0\u8f93\u548c\u6d3b\u52a8\u3002\u4e3a\u4e86\u5c06\u4fe1\u53f7\u4e0e\u751f\u547d\u7cfb\u7edf\u4e2d\u7684\u5206\u5b50\u72b6\u6001\u6216\u751f\u7269\u4e8b\u4ef6\u76f8\u5173\u8054\uff0c\u5df2\u7ecf\u5f00\u53d1\u4e86\u8bb8\u591a\u5177\u6709\u9488\u5bf9\u751f\u7269\u6807\u5fd7\u7269\u7684\u9776\u5411\u6216\u7ed3\u5408\u80fd\u529b\u7684\u201c\u59cb\u7ec8\u5728\u7ebf\u201d\u63a2\u9488\u3002\u7136\u800c\uff0c\u7531\u4e8e\u975e\u7279\u5f02\u6027\u76f8\u4e92\u4f5c\u7528\uff0c\u5b83\u4eec\u5177\u6709\u8f83\u5dee\u7684\u4fe1\u53f7\u7279\u5f02\u6027\u548c\u4f4e\u4fe1\u566a\u6bd4\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u53ea\u6709\u5728\u4e0e\u611f\u5174\u8da3\u7684\u751f\u7269\u6807\u5fd7\u7269\u76f8\u4e92\u4f5c\u7528\u540e\u624d\u88ab\u6fc0\u6d3b\u4ee5\u53d1\u51fa\u8367\u5149\u6216\u5316\u5b66\u53d1\u5149\u7684\u63a2\u9488\u4f1a\u4ea7\u751f\u66f4\u9ad8\u7684\u4fe1\u53f7\u80cc\u666f\u6bd4\u548c\u66f4\u4f4e\u7684\u68c0\u6d4b\u9650\uff0c\u4ece\u800c\u63d0\u9ad8\u4f53\u5916\u548c\u4f53\u5185\u5149\u5b66\u6210\u50cf\u7684\u6027\u80fd\u3002\u56e0\u6b64\uff0c\u53ef\u6fc0\u6d3b\u63a2\u9488\u7684\u5f00\u53d1\u6709\u52a9\u4e8e\u66f4\u597d\u5730\u4e86\u89e3\u548c\u8bca\u65ad\u764c\u75c7\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u6025\u6027\u5668\u5b98\u8870\u7aed\u548c\u7ec6\u83cc\u611f\u67d3\u7b49\u75be\u75c5\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u5df4\u65af\u5927\u5b66Tony James&\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u6d66\u4f83\u88d4<\/b><\/strong>\u603b\u7ed3\u4e86\u5f00\u53d1\u7528\u4e8e\u751f\u547d\u7cfb\u7edf\u751f\u7269\u6210\u50cf\u7684\u53cc\u91cd\u63a2\u9488\u7684\u8fdb\u5c55\u3002\u6587\u7ae0\u7279\u522b\u5173\u6ce8\u7528\u4e8e\u751f\u6210\u5177\u6709\u5b9a\u5236\u5149\u5b66\u7279\u6027\u7684\u53cc\u91cd\u63a2\u9488\u7684\u4e0d\u540c\u5316\u5b66\u7ed3\u6784\uff0c\u5e76\u4fc3\u8fdb\u5b83\u4eec\u5bf9\u4e0d\u540c\u751f\u7269\u6807\u5fd7\u7269\u7684\u7279\u5b9a\u6fc0\u6d3b\u3002\u4f5c\u8005\u7684\u76ee\u7684\u662f\u6982\u8ff0\u76ee\u524d\u53ef\u7528\u4e8e\u4f7f\u7528\u8fd9\u79cd\u53cc\u9501\u65b9\u6cd5\u68c0\u6d4b\u751f\u7269\u73af\u5883\u4e2d\u7684\u4e24\u79cd\u751f\u7269\u6807\u5fd7\u7269\u6216\u4e00\u79cd\u751f\u7269\u6807\u5fd7\u7269\u4e0e\u53e6\u4e00\u79cd\u523a\u6fc0\uff08\u4f8b\u5982\u5149\u7167\u5c04\uff09\u76f8\u7ed3\u5408\u7684\u5de5\u5177\u548c\u7b56\u7565\u3002 \u9664\u4e86\u8fd9\u4e2a\u76ee\u6807\uff0c\u4f5c\u8005\u9996\u5148\u63cf\u8ff0\u4e86\u53cc\u9501\u63a2\u9488\u6784\u5efa\u4e2d\u4f7f\u7528\u7684\u4e0d\u540c\u8bbe\u8ba1\u7b56\u7565\uff0c\u5e76\u91cd\u70b9\u4ecb\u7ecd\u4e86\u7528\u4e8e\u68c0\u6d4b\u5177\u6709\u751f\u7269\u5b66\u610f\u4e49\u7684\u751f\u7269\u5206\u5b50\u7684\u4ee3\u8868\u6027\u793a\u4f8b\u3002\u4f5c\u8005\u6700\u540e\u8ba8\u8bba\u4e86\u8be5\u9886\u57df\u5f53\u524d\u548c\u672a\u6765\u7684\u6311\u6218\uff0c\u7279\u522b\u5f3a\u8c03\u4e86\u5bf9\u529f\u80fd\u6027\u53cc\u9501\u5b9a\u63a2\u9488\u7684\u672a\u6ee1\u8db3\u9700\u6c42\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201c<\/strong>Dual-locked spectroscopic probes for sensing and therapy<\/strong>\u201d<\/strong>\u53d1\u8868\u5728Nat. Rev. Chem<\/b><\/strong>\u4e0a<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe<\/b><\/strong>1<\/strong>.<\/strong>\u5305\u542b\u4e24\u4e2a\u53cd\u5e94\u4f4d\u70b9\u7684\u53cc\u9501\u63a2\u9488\uff0c\u53ef\u8fdb\u884c\u4e24\u6b21\u8fde\u7eed\u53cd\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6982\u5ff5\u793a\u610f\u56fe (b) \u4ee3\u8868\u6027\u63a2\u9488 DCm-gal-CF \u548c Qm-B-CF \u7684\u5316\u5b66\u7ed3\u6784 (c) \u4ee3\u8868\u6027\u63a2\u9488 (PeG-Ae-5-DFUr) \u7684\u5316\u5b66\u7ed3\u6784\u53ca\u5176\u54cd\u5e94 H2O2 \u548c 1O2 \u7684\u6d3b\u5316\u5f62\u5f0f (d) APtN\u6d3b\u5316\u524d\u540e\u7684\u53d1\u5149\u5149\u8c31 \uff08e\uff09APtN \u5728\u6a21\u62df\u80bf\u7624\u5fae\u73af\u5883\u7684\u9178\u6027\u6761\u4ef6\uff08pH = 6.0\uff09\u548c PBS\uff08pH = 7.4\uff09\u4e2d\u5728\u4e0d\u5b58\u5728\u6216\u5b58\u5728 H2O2 \u7684\u60c5\u51b5\u4e0b\u7684 5DFUR \u91ca\u653e\u66f2\u7ebf (f) \u7531\u751f\u7269\u6807\u5fd7\u7269\u548c\u5149\u8f90\u5c04\u5f15\u53d1\u7684\u4e24\u4e2a\u72ec\u7acb\u53cd\u5e94\u6fc0\u6d3b\u7684\u53cc\u9501\u5b9a\u63a2\u9488<\/p>\n

\u56fe<\/b><\/strong>2.\u53cc\u9501\u63a2\u9488\u5305\u542b\u4e00\u4e2a\u53cd\u5e94\u4f4d\u70b9\uff0c\u53ef\u8fdb\u884c\u4e24\u6b21\u8fde\u7eed\u53cd\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6982\u5ff5\u793a\u610f\u56fe (b) \u4ee3\u8868\u6027\u63a2\u9488 (NmL) \u7684\u5316\u5b66\u7ed3\u6784\u53ca\u5176\u54cd\u5e94\u4eae\u6c28\u9178\u6c28\u80bd\u9176 (LAP) \u548c\u5355\u80fa\u6c27\u5316\u9176 (MAO) \u7684\u5f62\u5f0f (c-d) \u5728 LAP \u548c\/\u6216 MAO \u5b58\u5728\u4e0b NmL \u7684\u5f52\u4e00\u5316\u5438\u6536\u5149\u8c31\u548c\u8367\u5149\u54cd\u5e94 (e-f) \u4f7f\u7528\u4e24\u4e2a\u8fde\u7eed\u53cd\u5e94\u64cd\u4f5c\u7684\u53cc\u9501\u5b9a\u63a2\u9488\u7684\u4e24\u4e2a\u4f8b\u5b50<\/p>\n

\u56fe3.\u53cc\u9501\u63a2\u9488\u5305\u542b\u4e24\u4e2a\u53cd\u5e94\u4f4d\u70b9\uff0c\u53ef\u5b9e\u73b0\u4fe1\u53f7\u6fc0\u6d3b\u548c\u9776\u5411<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6982\u5ff5\u793a\u610f\u56fe (b) \u4ee3\u8868\u6027\u63a2\u9488 (CaGF) \u7684\u5316\u5b66\u7ed3\u6784 (c) \u63a2\u9488 CDG-tre \u88ab \u03b2-\u5185\u9170\u80fa\u9176 (BlaC) \u6fc0\u6d3b\uff0c\u5f97\u5230 6-TG-Tre\uff0cAg85 \u9176\u5c06\u5176\u52a0\u5de5\u6210 6-TG-Tre \u5355\u83cc\u9178 (6-TG-Tre-MM)\uff0c\u901a\u8fc7\u5206\u679d\u6746\u83cc\u94fe\u8f6c\u79fb\u4ece \u53e6\u4e00\u5206\u5b50\u6d77\u85fb\u7cd6\u5355\u9709\u83cc\u9178\u916f (TMM) (d) \u53cc\u9776\u5411\u8367\u5149\u63a2\u9488 (CDG-DNBs) \u7684\u7ed3\u6784\u4ee5\u53ca\u4e0e BlaC \u548c decaprenylphosphoryl-\u03b2-d-\u6838\u7cd6 2′-\u5dee\u5411\u5f02\u6784\u9176 (DprE1) \u7684\u53cd\u5e94 (e) \u53cc\u9501\u5b9a\u63a2\u9488 mCCL2-mAF \u7684\u7ed3\u6784<\/p>\n

\u56fe<\/b><\/strong>4<\/strong>.<\/b><\/strong>\u53cc\u9501\u63a2\u9488\u5305\u542b\u4e00\u4e2a\u53ef\u4ee5\u8fdb\u884c\u4e24\u4e2a\u72ec\u7acb\u53cd\u5e94\u7684\u8367\u5149\u56e2<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6982\u5ff5\u793a\u610f\u56fe (b) \u4ee3\u8868\u6027\u63a2\u9488 (FhZ) \u7684\u5316\u5b66\u7ed3\u6784\u53ca\u5176\u5206\u522b\u54cd\u5e94\u2022OH \u548c HClO \u7684\u6d3b\u5316\u5f62\u5f0f (c) \u5728\u4e0d\u5b58\u5728\u6216\u5b58\u5728\u4e0d\u540c\u5f53\u91cf HClO \u7684\u60c5\u51b5\u4e0b FhZ \u7684\u8367\u5149\u54cd\u5e94 (d) FhZ \u5728\u4e0d\u540c\u5f53\u91cf\u7684\u2022OH \u5b58\u5728\u6216\u4e0d\u5b58\u5728\u4e0b\u7684\u8367\u5149\u54cd\u5e94 (e) \u57fa\u4e8e\u4e00\u4e2a\u8367\u5149\u56e2\u7684\u53cc\u9501\u5b9a\u63a2\u9488<\/p>\n

\u56fe<\/b><\/strong>5<\/b><\/strong>.\u57fa\u4e8e\u7528\u4e8e\u53cc\u5de5\u6210\u50cf\u7684\u4e24\u4e2a\u53d1\u5149\u56e2\u7684\u53cc\u9501\u5b9a\u63a2\u9488<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6982\u5ff5\u793a\u610f\u56fe (b) \u4ee3\u8868\u6027\u63a2\u9488 (ADr) \u7684\u5316\u5b66\u7ed3\u6784\u53ca\u5176\u54cd\u5e94 O2\u2022- \u548c NAG \u7684\u6d3b\u5316\u5f62\u5f0f (c-d) \u5728 PBS \u4e2d\u4e0d\u5b58\u5728\u6216\u5b58\u5728 KO2 \u6216 NAG \u7684\u60c5\u51b5\u4e0b ADr \u7684\u8367\u5149\u548c\u5316\u5b66\u53d1\u5149\u5149\u8c31 (e) \u53cc\u6fc0\u6d3b\u63a2\u9488\u5747\u57fa\u4e8e\u7528\u4e8e\u53cc\u5de5\u6210\u50cf\u7684\u4e24\u4e2a\u53d1\u5149\u56e2\u8fdb\u884c\u64cd\u4f5c (f) tFP \u5bf9\u6dfb\u52a0\u4e0d\u540c\u6d53\u5ea6 H2O2\uff080\u30010.4\u30011\u30012\u30014\u30016\u30018\u300110\u300112 \u548c 15 \u03bcM\uff09\u7684\u53cc\u5149\u5b50\u8367\u5149\u54cd\u5e94 (g) tFP \u5bf9\u6dfb\u52a0\u4e0d\u540c\u6d53\u5ea6\uff080\u30010.5\u30011\u30013\u30016\u30019\u300112\u300115\u300118 \u548c 21 mM\uff09ATP \u7684\u53cc\u5149\u5b50\u8367\u5149\u54cd\u5e94<\/p>\n

\u56fe<\/b><\/strong>6.<\/b><\/strong>\u57fa\u4e8e AND \u903b\u8f91\u7684\u5355\u5206\u5b50\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6982\u5ff5\u793a\u610f\u56fe (b-c) \u7528\u4e8e\u68c0\u6d4b AP \u548c ME \u7684\u63a2\u9488 C1 (d) \u4f7f\u7528\u4e0d\u540c\u8367\u5149\u56e2\u7684\u5176\u4ed6\u57fa\u4e8e AND \u903b\u8f91\u7684\u63a2\u9488<\/p>\n

\u56fe<\/b><\/strong>7<\/b><\/strong>.\u4f7f\u7528\u4e24\u4e2a\u524d\u4f53\u63a2\u9488\u7684\u57fa\u4e8e AND \u903b\u8f91\u7684\u7cfb\u7edf<\/b><\/strong>\"\"<\/b><\/strong><\/p>\n

(a) \u6982\u5ff5\u793a\u610f\u56fe (b) \u901a\u8fc7\u91ca\u653e 6-\u7f9f\u57fa-2-\u6c30\u57fa\u82ef\u5e76\u567b\u5511\u548c d-\u534a\u80f1\u6c28\u9178\u4ee5\u53ca\u539f\u4f4d\u5f62\u6210\u8367\u5149\u7d20\u540c\u65f6\u68c0\u6d4b H2O2 \u548c caspase 8 \u6d3b\u6027\u7684\u8bbe\u8ba1\u7b56\u7565<\/p>\n

\u56fe<\/strong>8<\/b><\/strong>.<\/b><\/strong>\u53cc\u9501\u8367\u5149\u63a2\u9488\u6784\u5efa\u4e2d\u7684\u798f\u65af\u7279\u5171\u632f\u80fd\u91cf\u8f6c\u79fb<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4f7f\u7528\u4e24\u4e2a\u8367\u5149\u56e2\u548c\u4e24\u4e2a\u54cd\u5e94\u4f4d\u70b9\u7684\u57fa\u4e8e F\u00f6rster \u5171\u632f\u80fd\u91cf\u8f6c\u79fb (FRET) \u7684\u7cfb\u7edf\u7684\u8bbe\u8ba1\u6982\u5ff5 (b) \u57fa\u4e8ea\u4e2d\u6240\u793a\u7684 FRET \u7c7b\u578b\u64cd\u4f5c\u7684\u53cc\u9501\u5b9a\u63a2\u9488 (c) \u5305\u542b\u4e00\u4e2a\u54cd\u5e94\u5355\u5143\u7684\u57fa\u4e8e FRET \u7684\u53cc\u9501\u5b9a\u63a2\u9488\u7684\u8bbe\u8ba1\u6982\u5ff5 (d) Ly-Nt-sP \u7684\u5206\u5b50\u8bbe\u8ba1\u548c\u5bf9 SO2 \u63d0\u51fa\u7684\u4f20\u611f\u673a\u5236<\/p>\n

\u56fe<\/b><\/strong>9.<\/b><\/strong>\u5728\u53cc\u9501\u7cfb\u7edf\u4e2d\u8fde\u7eed\u6dfb\u52a0\u4e24\u79cd\u5206\u6790\u7269\u4ee5\u8bf1\u5bfc\u4e24\u79cd\u4e0d\u540c\u7684\u8367\u5149\u901a\u9053<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6982\u5ff5\u793a\u610f\u56fe (b) \u63a2\u9488 3-hF-Ome \u4e0e\u6dc0\u7c89\u6837\u86cb\u767d-\u03b2 (A\u03b2) \u805a\u96c6\u4f53\u7684\u62df\u8bae\u76f8\u4e92\u4f5c\u7528\u53ca\u5176\u4f5c\u4e3a\u65b0\u7684\u4e3b\u5ba2\u4f53\u7cfb\u7edf\u7528\u4e8e\u8fc7\u6c27\u4e9a\u785d\u9178\u76d0 (ONOO-) \u7684\u6bd4\u4f8b\u4f20\u611f\u7684\u793a\u610f\u56fe (c) \u7528\u4e8e O2\u2022\u2212 \u548c H2Sn \u68c0\u6d4b\u7684\u63a2\u9488 hCy-FN \u7684\u62df\u8bae\u53cd\u5e94\u673a\u5236 (d) \u5e8f\u5217\u6fc0\u6d3b\u53cc\u901a\u9053\u8fd1\u7ea2\u5916\u6cbb\u7597\u8bca\u65ad\u7eb3\u7c73\u524d\u836f\u7684\u8bbe\u8ba1<\/p>\n

\u56fe<\/b><\/strong>10<\/b><\/strong>.\u5176\u4ed6\u7c7b\u578b\u7684\u53cc\u9501\u8367\u5149\u63a2\u9488<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5177\u6709\u4e00\u4e2a\u53cd\u5e94\u4f4d\u70b9\u7684\u975e\u8367\u5149\u53cc\u9501\u63a2\u9488\u7684\u793a\u610f\u56fe\uff0c\u53ef\u4ea7\u751f\u4e24\u79cd\u4e0d\u540c\u7684\u8367\u5149\u4fe1\u53f7 (b) \u5206\u522b\u5728\u534a\u80f1\u6c28\u9178 (Cys) \u548c\u8c37\u80f1\u7518\u80bd (GSH) \u5b58\u5728\u4e0b\u4e0e NO \u7684\u53cd\u5e94\u673a\u5236 (c) \u53cc\u9501\u63a2\u9488 13 \u5bf9\u7f3a\u6c27\u548c NO \u4e0e\u82ef\u4e01\u9178\u6c2e\u82a5\u91ca\u653e\u7684\u5de5\u4f5c\u534f\u8bae (d) \u5e26\u6709\u4e00\u4e2a\u53cd\u5e94\u4f4d\u70b9\u7684\u8367\u5149\u53cc\u9501\u63a2\u9488\u7684\u793a\u610f\u56fe\uff0c\u8be5\u63a2\u9488\u53ef\u4ee5\u4ea7\u751f\u8367\u5149\u4e2d\u95f4\u4f53\uff0c\u7136\u540e\u5728\u5149\u7167\u5c04\u4e0b\u4ea7\u751f\u4e00\u79cd\u975e\u8367\u5149\u4ea7\u7269\u5e76\u91ca\u653e\u6cbb\u7597\u5242 (e) FB\u7684\u5316\u5b66\u7ed3\u6784\u548c\u76f8\u5e94\u7684CO\u5149\u91ca\u653e\u673a\u5236<\/p>\n

\u3010<\/b><\/strong>\u5c0f\u7ed3<\/b><\/strong>\u3011<\/b><\/strong><\/p>\n

\u5149\u5b66\u6210\u50cf\u63a2\u9488\u80fd\u591f\u4ee5\u975e\u4fb5\u5165\u6027\u7684\u7eb5\u5411\u65b9\u5f0f\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u68c0\u6d4b\u548c\u63ed\u793a\u76ee\u6807\u5206\u6790\u7269\u7684\u751f\u7406\u548c\u75c5\u7406\u529f\u80fd\u3002\u5149\u5b66\u6210\u50cf\u63a2\u9488\u5177\u6709\u7b80\u5355\u3001\u6210\u672c\u4f4e\u3001\u7075\u654f\u5ea6\u9ad8\u3001\u9002\u5e94\u81ea\u52a8\u5316\u5206\u6790\u3001\u7a7a\u95f4\u5206\u8fa8\u6210\u50cf\u80fd\u529b\u5f3a\u3001\u4fe1\u53f7\u8f93\u51fa\u6a21\u5f0f\u591a\u6837\u7b49\u4f18\u70b9\uff0c\u5df2\u5e7f\u6cdb\u5e94\u7528\u4e8e\u751f\u7269\u5b66\u3001\u751f\u7406\u5b66\u3001\u836f\u7406\u5b66\u548c\u533b\u5b66\u7b49\u9886\u57df\u3002\u4e3a\u4e86\u6784\u5efa\u53ef\u9760\u4e14\u4e0e\u5b9e\u9645\/\u4e34\u5e8a\u76f8\u5173\u7684\u63a2\u9488\uff0c\u8bbe\u8ba1\u8fc7\u7a0b\u901a\u5e38\u5305\u542b\u591a\u5b66\u79d1\u4e3b\u9898\uff0c\u5305\u62ec\u5316\u5b66\u3001\u751f\u7269\u5b66\u548c\u533b\u5b66\u3002\u5728\u63a2\u9488\u5e93\u4e2d\uff0c\u53cc\u9501\u5b9a\u7cfb\u7edf\u7279\u522b\u6709\u8da3\uff0c\u56e0\u4e3a\u5b83\u4eec\u80fd\u591f\u63d0\u4f9b\u589e\u5f3a\u7684\u7279\u5f02\u6027\u548c\u591a\u91cd\u68c0\u6d4b\u3002\u6b64\u5916\uff0c\u5316\u5b66\u53d1\u5149\u662f\u4e00\u79cd\u4f4e\u80cc\u666f\u3001\u65e0\u6fc0\u53d1\u7684\u5149\u5b66\u6a21\u5f0f\uff0c\u56e0\u6b64\u53ef\u4ee5\u96c6\u6210\u5230\u53cc\u9501\u5b9a\u7cfb\u7edf\u4e2d\uff0c\u5141\u8bb8\u5bf9\u4e24\u79cd\u4e0d\u540c\u7684\u751f\u7269\u6807\u5fd7\u7269\u8fdb\u884c\u65e0\u4e32\u6270\u7684\u8367\u5149\u548c\u5316\u5b66\u53d1\u5149\u68c0\u6d4b\u3002\u5bf9\u4e8e\u8bb8\u591a\u7814\u7a76\u4eba\u5458\u6765\u8bf4\uff0c\u8fd9\u4e9b\u53cc\u9501\u7cfb\u7edf\u4ecd\u7136\u662f\u4e00\u4e2a\u201c\u9ed1\u5323\u5b50\u201d\u3002\u56e0\u6b64\uff0c\u672c\u7efc\u8ff0\u65e8\u5728\u4e3a\u6b64\u7c7b\u53cc\u9501\u7cfb\u7edf\u63d0\u4f9b\u201c\u521d\u5b66\u8005\u6307\u5357\u201d\uff0c\u7b80\u5355\u89e3\u91ca\u5b83\u4eec\u7684\u5de5\u4f5c\u539f\u7406\u3001\u529f\u80fd\u548c\u5e94\u7528\u573a\u5408\uff0c\u4ee5\u5e2e\u52a9\u8bfb\u8005\u66f4\u6df1\u5165\u5730\u4e86\u89e3\u8fd9\u79cd\u7814\u7a76\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/b><\/strong>\uff1aDual-locked spectroscopic probes for sensing and therapy. Nat. Rev. Chem., <\/em>202<\/strong>1<\/strong>, DOI:10.1038\/s41570-021-00277-2<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4tt\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

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