{"id":222621,"date":"2021-06-06T06:30:57","date_gmt":"2021-06-05T22:30:57","guid":{"rendered":"\/\/m.iemloyee.com\/?p=222621"},"modified":"2021-06-05T21:31:29","modified_gmt":"2021-06-05T13:31:29","slug":"%e3%80%90oa%e3%80%91%e5%9b%9b%e5%b7%9d%e5%a4%a7%e5%ad%a6%e5%86%af%e5%b0%8f%e6%98%8e%e8%af%be%e9%a2%98%e7%bb%84%e5%8a%a9%e5%8a%9b%e5%82%ac%e5%8c%96%e4%b8%8d%e5%af%b9%e7%a7%b0nakamura%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=222621","title":{"rendered":"\u56db\u5ddd\u5927\u5b66\u51af\u5c0f\u660e\u8bfe\u9898\u7ec4\u52a9\u529b\u50ac\u5316\u4e0d\u5bf9\u79f0Nakamura\u53cd\u5e94"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u5728\u672a\u6d3b\u5316\u7684\u7094\u70c3\u4e2d\u6dfb\u52a0\u6ca1\u6709\u4e8b\u5148\u5f62\u6210\u70ef\u9187\u5316\u7269\u7684\u7fb0\u57fa\u5316\u5408\u7269\u662f\u5f62\u6210\u78b3-\u78b3\u952e\u7684\u4e00\u79cd\u539f\u5b50\u7ecf\u6d4e\u7684\u65b9\u6cd5\u3002\u5728\u4e59\u70ef\u57fa\u7684\u90bb\u4f4d\u5f15\u5165\u4e59\u70ef\u57fa\u53d6\u4ee3\u57fa\uff0c\u5728\u5929\u7136\u4ea7\u7269\u548c\u836f\u7269\u7684\u6709\u673a\u5408\u6210\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002\u4ea7\u751f\u73af\u70ef\u70c3\u884d\u751f\u7269\u7684\u5206\u5b50\u5185\u7c7b\u578b\u5df2\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\u3002\u9664\u4e86\u975e\u5bf9\u6620\u9009\u62e9\u6027\u4f53\u7cfb\u5916\uff0c\u8fd8\u901a\u8fc7\u534f\u540c\u7684\u786c\/\u8f6f\u8def\u6613\u65af\u9178\u50ac\u5316\u5242\uff08\u4f8b\u5982\uff0cPd\/Yb\uff0cYb\/Zn\uff0cAg\/La\uff0cAg\/Fe\uff09\uff0c\u8def\u6613\u65af\u78b1\u5b9e\u73b0\u4e86\u50ac\u5316\u4e0d\u5bf9\u79f0Conia-ene\u53cd\u5e94\u3002\u76f8\u53cd\uff0c1,3-\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\u4e0e\u672a\u6d3b\u5316\u76841-\u7094\u70c3\u7684\u5206\u5b50\u95f4\u53cd\u5e94\u7684\u7814\u7a76\u8f83\u5c11\u3002\u7531\u4e8e\u4e0d\u5229\u7684\u70ed\u529b\u5b66\uff0c\u4e0e1,3-\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\u7684HOMO\u76f8\u6bd4\uff0c\u672a\u6d3b\u5316\u7684\u7094\u70c3\u5177\u6709\u8f83\u9ad8\u7684LUMO\uff0c\u56e0\u6b64\u8be5\u65b9\u6cd5\u662f\u4e0d\u53ef\u884c\u7684\u30022003\u5e74\uff0cNakamura\u7b49\u4eba\u62a5\u9053\u4e86\u5728\u672a\u6d3b\u5316\u76841-\u7094\u70c3\u4e2d\u94df\u50ac\u5316\u76841,3-\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\u7684\u52a0\u6210\u53cd\u5e94\uff0c\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u6548\u7684\u5408\u6210\u8def\u7ebf\uff0c\u53ef\u4ece\u5927\u91cf\u7684\u78b3\u7094\u70c3\u6765\u6e90\u5f62\u62102-\u70ef\u57fa-1,3-\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\u3002\u4e4b\u540e\uff0c\u53d1\u73b0\u4e86In\uff08III\uff09\uff0cRe\uff08I\uff09\uff0cIr\uff08I\uff09\uff0cPd\uff080\uff09\uff0cCo\uff08II\uff09\uff0cMn\uff08I\uff09\u548cRu\uff08I\uff09-\uff08III\uff09\u50ac\u5316\u4f53\u7cfb\uff0c\u6240\u6709\u8fd9\u4e9b\u5916\u6d88\u65cb\u4f53\u62a5\u544a\uff0c\u4ec5\u4e00\u4e2a\u5b9e\u4f8b\u662f\u4f7f\u7528\u5e26\u6709\u624b\u6027\u52a9\u5242\u7684\u5e95\u7269\u3002\u4ee5\u4e0a\u6240\u6709\u62a5\u9053\u4e2d\uff0c\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\u548c\u7094\u70c3\u9700\u8981\u540c\u65f6\u88ab\u6d3b\u5316\u3002\u9664\u6b64\u4e4b\u5916\uff0cShi\u5c0f\u7ec4\u62a5\u9053\u4e86\u5728Nakamura\u53cd\u5e94\u4e2d\u7684\u534f\u540cAu\uff08I\uff09\/Ga\uff08III\uff09\u50ac\u5316\u4f5c\u7528\uff0c\u5176\u4e2dAu\uff08I\uff09\u6d3b\u5316\u4e86\u7094\u70c3\uff0c\u800cGa\uff08III\uff09\u589e\u5f3a\u4e861,3-\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\u7684\u9178\u5ea6\uff0c\u5916\u6d88\u65cb\u76842-\u70ef\u57fa-1,3-\u4e8c\u7fb0\u57fa\u4ea7\u7269\u3002\u901a\u5e38\uff0c\u6240\u6709\u7684Nakamura\u53cd\u5e94\u4ecd\u4ec5\u9650\u4e8e\u5916\u6d88\u65cb\u7684\u4f8b\u5b50\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u00a0<\/b><\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0<\/b><\/strong>\u00a0<\/b><\/strong>\u00a0\u5206\u5b50\u95f4\u5c06\u70ef\u9187\u548c\u70ef\u9187\u5316\u7269\u52a0\u6210\u81f3\u672a\u6d3b\u5316\u7684\u7094\u70c3\u662f\u4e00\u79cd\u7b80\u5355\u800c\u6709\u6548\u7684\u78b3-\u78b3\u952e\u5f62\u6210\u65b9\u6cd5\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5c1a\u672a\u5b9e\u73b0\u7094\u4e0e1,3-\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\u7684\u50ac\u5316\u4e0d\u5bf9\u79f0\u5f62\u5f0f\u3002\u56db\u5ddd\u5927\u5b66\u51af\u5c0f\u660e&\u6797\u4e3d\u4e3d<\/b><\/strong>\u5b9e\u73b0\u4e86\u5c061,3-\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\u50ac\u5316\u4e0d\u5bf9\u79f0\u5206\u5b50\u95f4\u52a0\u6210\u81f3\u672a\u6d3b\u5316\u76841-\u7094\u70c3\uff0c\u8fd9\u5f52\u56e0\u4e8e\u624b\u6027N,N’-\u4e8c\u6c27\u5316\u7269-\u94df\uff08III\uff09\u6216\u954d\uff08II\uff09\u8def\u6613\u65af\u9178\u548c\u975e\u624b\u6027\u91d1(I)\u03c0-\u9178\u7684\u534f\u540c\u6d3b\u5316\u3002\u4e00\u7cfb\u5217\u03b2-\u916e\u9170\u80fa\uff0c\u03b2-\u916e\u9178\u916f\u548c1,3-\u4e8c\u916e\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u826f\u597d\u7684\u8f6c\u5316\u7387\u8f6c\u5316\u4e3a\u5177\u6709\u56db\u53d6\u4ee3\u624b\u6027\u4e2d\u5fc3\u7684\u76f8\u5e94\u4ea7\u7269\u3002\u6b64\u5916\uff0c\u5728\u5b9e\u9a8c\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0c\u63d0\u51fa\u4e86\u53ef\u80fd\u7684\u50ac\u5316\u5faa\u73af\u548c\u8fc7\u6e21\u6001\u6a21\u578b\uff0c\u4ee5\u8bf4\u660e\u53cd\u5e94\u8fc7\u7a0b\u548c\u624b\u6027\u8bf1\u5bfc\u7684\u8d77\u6e90\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201c<\/strong>Catalytic asymmetric Nakamura reaction by gold(I)\/chiral N,N<\/strong>\u2019<\/strong>-dioxide-indium(III) or nickel(II) synergistic catalysis<\/strong>\u201d<\/strong>\u53d1\u8868\u5728Nat. Commun.<\/b><\/strong>\u4e0a<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe1<\/strong>.<\/strong>1,3-\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\u5411\u7094\u70c3\u7684\u50ac\u5316\u4e0d\u5bf9\u79f0\u52a0\u6210<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u50ac\u5316\u4e0d\u5bf9\u79f0\u90bb\u82ef\u4e8c\u70ef\u53cd\u5e94 \uff08b\uff09Nakamura\u53cd\u5e94\u7684\u53d1\u5c55 \uff08c\uff09\u50ac\u5316Nakamura\u4e0d\u5bf9\u79f0\u53cd\u5e94\u7684\u7b56\u7565<\/p>\n

\u56fe<\/b><\/strong>2.\u03b2-\u916e\u9170\u80fa\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>3.\u03b2-\u916e\u9178\u916f\u548c1,3-\u4e8c\u916e\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/b><\/strong>4.<\/strong>\u03b1<\/strong>–<\/strong>\u53d6\u4ee3\u7684\u65e0\u73af\u03b2-\u916e\u9170\u80fa\u7684\u5e95\u7269\u8303\u56f4\u9650\u5236<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>5<\/strong>.\u03b1-\u6c1f\u53d6\u4ee3\u7684\u65e0\u73af\u03b2-\u916e\u9170\u80fa\u7684\u5e95\u7269\u8303\u56f4<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/b><\/strong>6.\u673a\u7406\u7814\u7a76<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/b><\/strong>7.<\/strong>\u62df\u8bae\u7684\u50ac\u5316\u5faa\u73af\u548c\u8fc7\u6e21\u6001\u6a21\u578b<\/strong>\"\"<\/b><\/strong><\/p>\n

\u3010<\/b><\/strong>\u5c0f\u7ed3<\/b><\/strong>\u3011<\/b><\/strong><\/p>\n

\u5728\u8fd9\u9879\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u91d1(I)\/\u624b\u6027N,N’-\u4e8c\u6c27\u5316\u94df-\u94df(III)\u6216\u954d(II)\u534f\u540c\u50ac\u5316\u5242\u4f53\u7cfb\u3002\u5b83\u5b9e\u73b0\u4e86\u672a\u6d3b\u5316\u76841-\u7094\u70c3\u4e0e\u03b2-\u916e\u9170\u80fa\uff0c\u03b2-\u916e\u9178\u916f\u548c1,3-\u4e8c\u916e\u7684\u50ac\u5316\u4e0d\u5bf9\u79f0Nakamura\u53cd\u5e94\uff0c\u5177\u6709\u826f\u597d\u7684\u53cd\u5e94\u6027\u548c\u5bf9\u6620\u9009\u62e9\u6027\u3002\u673a\u7406\u7814\u7a76\u9610\u660e\u4e86\u53cd\u5e94\u8fc7\u7a0b\u548c\u624b\u6027\u8bf1\u5bfc\u7684\u8d77\u6e90\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/b><\/strong>\uff1aCatalytic asymmetric Nakamura reaction by gold(I)\/chiral N,N\u2019-dioxide-indium(III) or nickel(II) synergistic catalysis. Nat. Commun.<\/b><\/strong>, <\/em>202<\/strong>1<\/strong>, DOI:10.1038\/s41467-021-23105-z<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4tt\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u5728\u672a\u6d3b\u5316\u7684\u7094\u70c3\u4e2d\u6dfb\u52a0\u6ca1\u6709\u4e8b\u5148\u5f62\u6210\u70ef\u9187\u5316\u7269\u7684\u7fb0\u57fa\u5316\u5408\u7269\u662f\u5f62\u6210\u78b3-\u78b3\u952e\u7684\u4e00\u79cd\u539f\u5b50\u7ecf\u6d4e\u7684\u65b9\u6cd5\u3002\u5728\u4e59\u70ef\u57fa\u7684\u90bb\u4f4d\u5f15\u5165\u4e59\u70ef\u57fa\u53d6\u4ee3\u57fa\uff0c\u5728\u5929\u7136\u4ea7\u7269\u548c\u836f\u7269\u7684\u6709\u673a\u5408\u6210\u4e2d\u5177…<\/p>\n","protected":false},"author":7336,"featured_media":222622,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[4634],"class_list":["post-222621","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-4634"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/222621"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=222621"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/222621\/revisions"}],"predecessor-version":[{"id":222916,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/222621\/revisions\/222916"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/222622"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=222621"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=222621"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=222621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}