{"id":222341,"date":"2021-05-28T06:38:38","date_gmt":"2021-05-27T22:38:38","guid":{"rendered":"\/\/m.iemloyee.com\/?p=222341"},"modified":"2021-05-27T18:39:21","modified_gmt":"2021-05-27T10:39:21","slug":"%e4%b8%96%e7%95%8c%e6%80%a7%e7%97%85%e6%af%92%e4%bc%a0%e6%92%ad%e7%9a%84%e5%bf%ab%e9%80%9f%e6%a3%80%e6%b5%8b-%e6%9c%89%e5%8f%af%e8%83%bd%e8%a2%ab%e8%bf%99%e7%a7%8d%e6%96%b0%e6%9d%90%e6%96%99%e8%a7%a3","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=222341","title":{"rendered":"\u4e16\u754c\u6027\u75c5\u6bd2\u4f20\u64ad\u7684\u5feb\u901f\u68c0\u6d4b \u6709\u53ef\u80fd\u88ab\u8fd9\u79cd\u65b0\u6750\u6599\u89e3\u51b3\u5417\uff1f"},"content":{"rendered":"

1. \u524d\u8a00\u4ecb\u7ecd<\/b><\/strong><\/p>\n

\u75c5\u6bd2\u662f\u4e00\u79cd\u7531\u86cb\u767d\u8d28\u5916\u58f3\u4e2d\u7684\u6838\u9178\u5206\u5b50\u7ec4\u6210\u7684\u4e9a\u663e\u5fae\u611f\u67d3\u56e0\u5b50\u3002\u8fd9\u79cd\u7ed3\u6784\u4e0a\u7684\u7b80\u5355\u610f\u5473\u7740\u75c5\u6bd2\u4e0d\u80fd\u81ea\u5df1\u590d\u5236\uff0c\u5fc5\u987b\u6e17\u900f\u5e76\u9694\u79bb\u6d3b\u7ec6\u80de\u7684\u7e41\u6b96\u673a\u5236\u6765\u8fdb\u884c\u81ea\u8eab\u7684\u7e41\u6b96\u3002\u75c5\u6bd2\u9897\u7c92\u662f\u5bfc\u81f4\u8bf8\u5982\u6c34\u75d8\u3001\u6d41\u611f\u3001SARS\u3001\u57c3\u535a\u62c9\u3001\u83b7\u5f97\u6027\u514d\u75ab\u7f3a\u9677\u7efc\u5408\u5f81(\u827e\u6ecb\u75c5)\u7b49\u5927\u91cf\u75be\u75c5\u7684\u539f\u56e0\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u75c5\u6bd2\u9897\u7c92\u7684\u5c0f\u5c3a\u5bf8(\u901a\u5e38\u4ece20\u5230900 nm)\u4f7f\u5b83\u4eec\u96be\u4ee5\u5206\u79bb\u3002\u6b64\u5916\uff0c\u5b83\u4eec\u7684\u7ed3\u6784\u7b80\u5355\u6027\u8d4b\u4e88\u4e86\u5feb\u901f\u7684\u81ea\u53d1\u9002\u5e94\u548c\u8fdb\u5316\uff0c\u8fd9\u53ef\u80fd\u901a\u8fc7\u76f4\u63a5\u7684\u57fa\u56e0\u7a81\u53d8\u3001\u57fa\u56e0\u66ff\u6362\u6216\u91cd\u7ec4\u6765\u5b9e\u73b0\u3002<\/p>\n

\u75c5\u6bd2\u5f15\u8d77\u7684\u75c5\u7406\u5b66\u5b9e\u9a8c\u5ba4\u8bca\u65ad\u5728\u75ab\u60c5\u5e94\u5bf9\u5de5\u4f5c\u548c\u5efa\u7acb\u5b89\u5168\u3001\u5feb\u901f\u7684\u68c0\u6d4b\u7b56\u7565\u65b9\u9762\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u4f7f\u7528\u5546\u4e1a\u89e3\u51b3\u65b9\u6848\u68c0\u6d4b\u81f4\u75c5\u75c5\u6bd2\u9700\u8981\u7279\u5b9a\u7684\u5de5\u5177\u548c\u8d39\u529b\u7684\u5b9e\u9a8c\u5ba4\u7a0b\u5e8f\u3002\u8fd9\u4f7f\u5f97\u6bcf\u5929\u6309\u65f6\u68c0\u6d4b\u75c5\u6bd2\u611f\u67d3\u6210\u4e3a\u4efb\u4f55\u75ab\u60c5\u7684\u9650\u5236\u6b65\u9aa4\u3002\u56e0\u6b64\u4eba\u4eec\u8feb\u5207\u9700\u8981\u65b0\u7684\u8bca\u65ad\u5de5\u5177\uff0c\u8fd9\u4e9b\u5de5\u5177\u5feb\u901f\u63d0\u4f9b\u7ed9\u536b\u751f\u57fa\u7840\u8bbe\u65bd\u548c\u8bad\u7ec3\u6709\u7d20\u7684\u4eba\u5458\u7a00\u7f3a\u7684\u8d2b\u56f0\u548c\u519c\u6751\u6b20\u53d1\u8fbe\u5730\u533a\u3002\u91d1\u5c5e-\u6709\u673a\u6846\u67b6\uff08MOF\uff09\u5e7f\u4e3a\u4eba\u77e5\u7684\u5185\u5728\u7279\u6027\u6709\u53ef\u80fd\u514b\u670d\u75c5\u6bd2\u68c0\u6d4b\u56fa\u6709\u7684\u4e00\u4e9b\u6311\u6218\u3002<\/b><\/u><\/strong>MOF \u5df2\u7ecf\u662f\u529f\u80fd\u6027\u5668\u4ef6\u7684\u7ec4\u6210\u90e8\u5206\uff0c\u80fd\u591f\u5b9e\u73b0\u4e0d\u95f4\u65ad\u5730\u68c0\u6d4b\u5206\u5b50\u9776\u6807\u3002\u5728\u8fd9\u91cc\u6211\u4eec\u603b\u7ed3\u4e86\u5173\u4e8e\u7528\u4f5c\u81f4\u75c5\u75c5\u6bd2\u4f20\u611f\u5668\u7684MOFs\u7684\u7814\u7a76\u62a5\u9053\u3002<\/p>\n

2. MOFs\u5728\u75c5\u6bd2\u611f\u67d3\u68c0\u6d4b\u4e2d\u7684\u5e94\u7528<\/b><\/strong><\/p>\n

MOFs\u4f53\u73b0\u4e86\u56fa\u6709\u7279\u6027\u7684\u72ec\u7279\u7ec4\u5408\uff0c\u4f7f\u5176\u6210\u4e3a\u5206\u5b50\u8bc6\u522b\u548c\u751f\u7269\u4f20\u611f\u5e94\u7528\u7684\u4f18\u79c0\u5019\u9009\u6750\u6599:\u9ad8\u5b54\u9699\u7387\u3001\u5927\u8868\u9762\u79ef\u3001\u9ad8\u7ed3\u6676\u5ea6\u3001\u5f00\u653e\u7684\u7ed3\u6784\u3001\u6613\u4e8e\u8c03\u8282\u7684\u5316\u5b66\u7ec4\u6210\uff0c\u5e76\u4e14\u5b83\u4eec\u53ef\u4ee5\u901a\u8fc7\u5408\u6210\u540e\u529f\u80fd\u5316\u7684\u5f62\u5f0f\u4ee5\u591a\u79cd\u65b9\u5f0f\u8fdb\u884c\u6539\u6027\u3002\u6b64\u5916\uff0c\u8fd8\u53d1\u73b0\u8bb8\u591aMOFs\u5177\u6709\u8f83\u4f4e\u7684\u7ec6\u80de\u6bd2\u6027\uff0c\u662f\u751f\u7269\u5206\u5b50\u56fa\u5b9a\u548c\u4fdd\u62a4\u7684\u826f\u597d\u57fa\u8d28\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0cMOFs\u751f\u7269\u4f20\u611f\u5e73\u53f0\u5f00\u53d1\u4e86\u4e0d\u540c\u7684\u533b\u5b66\u548c\u4e34\u5e8a\u5e94\u7528\uff0c\u4f8b\u5982:a)\u764c\u75c7\u6216\u7cd6\u5c3f\u75c5\u7b49\u75be\u75c5\u7684\u5feb\u901f\u8bca\u65ad\u548c\u6cbb\u7597\uff1bb)\u75c5\u539f\u4f53\u68c0\u6d4b\uff1bc)\u836f\u7269\u53ca\u5176\u4ee3\u8c22\u7269\u7684\u6d4b\u91cf\uff1bd)\u53d1\u73b0\u65b0\u836f\uff0ce)\u8bc4\u4f30\u548c\u6d4b\u91cf\u751f\u7269\u6837\u54c1\u4e2d\u7684\u5206\u6790\u7269\uff0c\u5e76\u4f7f\u7528\u5feb\u901f\u6d4b\u8bd5\u65e9\u671f\u68c0\u6d4b\u75be\u75c5\u3002\u6b64\u5916\uff0c\u5bf9MOFs\u7684\u5149\u5438\u6536\u548c\u53d1\u5c04\u7279\u6027\u7684\u8c03\u63a7\u53ef\u4ee5\u4fc3\u8fdb\u5bf9\u7ec6\u80de\u548c\u751f\u7269\u5206\u5b50\u7684\u7279\u5f02\u6027\u5206\u5b50\u8bc6\u522b\u3002<\/p>\n

\u6700\u5e38\u62a5\u9053\u7684\u75c5\u6bd2\u68c0\u6d4b\u65b9\u6cd5\u662f\u57fa\u4e8e\u75c5\u6bd2\u6838\u9178\u5e8f\u5217\u7684\u9274\u5b9a\u3002\u591a\u6838\u82f7\u9178\u4f5c\u4e3a\u5f00\u53d1\u751f\u7269\u6742\u4ea4\u7cfb\u7edf\u7684\u5e73\u53f0\uff0c\u8be5\u7cfb\u7edf\u542b\u6709\u4e00\u6761\u53d1\u5c04\u67d3\u6599\u6807\u8bb0\u7684\u6838\u9178\u94fe\uff0c\u8be5\u6838\u9178\u94fe\u5177\u6709\u4e0e\u9776\u75c5\u6bd2\u6838\u9178\u4e92\u8865\u7684\u5e8f\u5217\u3002\u56fe1\u63cf\u8ff0\u4e86\u75c5\u6bd2\u6838\u9178\u68c0\u6d4b\u4e2d\u4f7f\u7528\u7684\u57fa\u4e8e\u591a\u6838\u82f7\u9178\u8367\u5149\u7684\u65b9\u6cd5\u6240\u6d89\u53ca\u7684\u4e00\u822c\u673a\u5236\u3002<\/p>\n

\u56fe1. \u57fa\u4e8eMOFs\u4fc3\u8fdb\u7684\u63a2\u9488\u53d1\u5c04\u6062\u590d\u7684\u4e0d\u540c\u76ee\u6807\u68c0\u6d4b\u8fc7\u7a0b\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\"\"<\/p>\n

2.1 \u57c3\u535a\u62c9\u75c5\u6bd2<\/b><\/strong><\/p>\n

\u57c3\u535a\u62c9\u75c5\u6bd2\uff08EV\uff09\u5c5e\u5305\u62ec\u516d\u4e2a\u5df2\u77e5\u7269\u79cd\uff0c\u4ee5\u5b83\u4eec\u9996\u6b21\u88ab\u53d1\u73b0\u7684\u5730\u533a\u547d\u540d:\u624e\u4f0a\u5c14\u57c3\u535a\u62c9\u75c5\u6bd2(ZEV)\u3001\u82cf\u4e39\u57c3\u535a\u62c9\u75c5\u6bd2(SEV)\u3001\u5854\u6797\u57c3\u535a\u62c9\u75c5\u6bd2(TFEV)\u3001\u672c\u8fea\u5e03\u7126\u57c3\u535a\u62c9\u75c5\u6bd2(BBEV)\u3001\u83b1\u65af\u987f\u57c3\u535a\u62c9\u75c5\u6bd2(REV)\u548c\u90a6\u5df4\u5229\u57c3\u535a\u62c9\u75c5\u6bd2(BEV)\u3002\u8fd9\u4e9b\u6bd2\u682a\u4e2d\u6709\u56db\u79cd(SEV\u3001BBEV\u3001TFEV\u548cZEV)\u53ef\u4ee5\u611f\u67d3\u4eba\u7c7b\uff0c\u6709\u4e9b\u5728\u8fc7\u53bb\u66fe\u5f15\u8d77\u4e25\u91cd\u7684\u51fa\u8840\u70ed\u66b4\u53d1\u3002\u6700\u8fd1\u7684\u4e00\u4e2a\u4f8b\u5b50\u662fZEV\uff0c\u5b83\u9020\u6210\u4e862014\u5e74\u897f\u975e\u7684\u4e00\u6b21\u6bc1\u706d\u6027\u6253\u51fb\u3002\u8be5\u75be\u75c5\u7684\u4e25\u91cd\u6027\u3001\u5176\u9ad8\u4f20\u67d3\u6027\u4f20\u64ad\u6f5c\u529b\u4ee5\u53ca\u5728\u6709\u6548\u75ab\u82d7\u5f00\u53d1\u65b9\u9762\u7f3a\u4e4f\u91cd\u5927\u8fdb\u5c55\uff0c\u4f7f\u5f97\u4eba\u4eec\u5bf9\u65e9\u671f\u68c0\u6d4b\uff0c\u7279\u522b\u662f\u5728\u6700\u5e38\u89c1\u7684\u53d7\u5f71\u54cd\u5730\u533a\u7684\u65e9\u671f\u68c0\u6d4b\u9ad8\u5ea6\u91cd\u89c6\u3002\u56e0\u6b64\uff0c\u76ee\u524d\u9700\u8981\u540c\u65f6\u5177\u6709\u9ad8\u7075\u654f\u5ea6\u548c\u5feb\u901f\u54cd\u5e94\u7684\u751f\u7269\u4f20\u611f\u5668\u3002<\/p>\n

Anal. Chem.<\/b><\/strong>\uff1a3D Cu\u57fa\u4e24\u6027\u79bb\u5b50MOFs\u75c5\u6bd2\u9009\u62e9\u6027\u8367\u5149\u751f\u7269\u4f20\u611f\u5668<\/b><\/strong><\/p>\n

\u5357\u65b9\u533b\u79d1\u5927\u5b66\u7684\u9648\u91d1\u9999\u548c\u9648\u6587\u534e<\/b><\/strong>\u4e24\u4f4d\u6559\u6388\u5236\u5907\u4e86\u4e00\u79cd\u6c34\u76f8\u7a33\u5b9a\u7684\u4e09\u7ef4\u94dc\u57fa\u91d1\u5c5e\u6709\u673a\u6846\u67b6(MOF)\u3002\u8be5MOF\u5177\u6709\u72ec\u7279\u7684\u5b54\u9699\u5f62\u72b6\uff0c\u5e26\u6709\u82b3\u9999\u73af\u3001\u5e26\u6b63\u7535\u8377\u7684\u5421\u5576\u548c\u4e0d\u9971\u548c\u7684Cu(II)\u9633\u79bb\u5b50\u4e2d\u5fc3\u3001\u6e38\u79bb\u7fa7\u9178\u3001\u9576\u5d4c\u7684H2<\/sub>O\u548c\u914d\u4f4d\u7684SO4<\/sub>2\u2212<\/sup>\u5728\u5b54\u9699\u8868\u9762\u3002\u8be5MOF\u53ef\u4ee5\u901a\u8fc7\u9759\u7535\u3001\u03c0-stacking\u548c\/\u6216\u6c22\u952e\u4e0e\u4e24\u4e2a\u7fa7\u57fa\u8367\u5149\u7d20(FAM)\u6807\u8bb0\u7684\u5355\u94feDNA\u5e8f\u5217\u76f8\u4e92\u4f5c\u7528\u5f62\u6210\u4e24\u4e2aP-DNA@MOF\u4f53\u7cfb\uff0c\u4ece\u800c\u901a\u8fc7\u5149\u8bf1\u5bfc\u7535\u5b50\u8f6c\u79fb\u8fc7\u7a0b\u731d\u706dFAM\u7684\u8367\u5149\u3002\u8fd9\u4e9bP-DNA@MOF\u7cfb\u7edf\u53ef\u4f5c\u4e3a\u6709\u6548\u7684\u8367\u5149\u4f20\u611f\u5668\u7528\u4e8e\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd21\u53cc\u94feDNA\u548c\u82cf\u4e39\u75c5\u6bd2RNA\u5e8f\u5217\uff0c\u68c0\u6d4b\u9650\u5206\u522b\u4e3a196 pM\u548c73 pM\uff0c\u8fd9\u8868\u660e\u654f\u611f\u6027\u9ad8\uff0c\u8fdc\u4f4e\u4e8e\u60a3\u8005\u901a\u5e38\u7684\u75c5\u6bd2\u8f7d\u91cf\uff0c\u5728\u75be\u75c5\u8fdb\u5c55\u7684\u7b2c\u4e8c\u5929\uff0c\u75c5\u6bd2\u8f7d\u91cf\u53ef\u9ad8\u8fbe107<\/sup>\u00a0RNA copies\/mL\u3002 \u00a0<\/p>\n

\"\"<\/p>\n

Platforms Formed from a Three-Dimensional Cu-Based Zwitterionic Metal\u2013Organic Framework and Probe ss-DNA: Selective Fluorescent Biosensors for Human Immunodeficiency Virus 1 ds-DNA and Sudan Virus RNA Sequences<\/u>. <\/u>Anal. Chem. 2015, 87, 24, 12206\u201312214<\/u><\/a><\/p>\n

\u8fd9\u9879\u7814\u7a76\u4e3a\u5728\u57fa\u4e8eMOFs\u751f\u7269\u4f20\u611f\u5668\u68c0\u6d4b\u75c5\u6bd2\u7684\u5f00\u53d1\u4e2d\u66f4\u5e7f\u6cdb\u5730\u4f7f\u7528\u8fd9\u4e9b\u7b56\u7565\u6216\u5176\u6539\u6027\u94fa\u5e73\u4e86\u9053\u8def\u3002\u4f8b\u5982\uff0c\u5b83\u663e\u7136\u5f15\u53d1\u4e86\u8fd9\u6837\u4e00\u4e2a\u95ee\u9898:\u7531\u4e8e\u4f7f\u7528\u66f4\u957f\u7684\u63a2\u9488DNA\u5e8f\u5217\uff0c\u4f7f\u7528\u66f4\u5927\u5b54\u5f84\u7684MOFs\u5982\u4f55\u5f71\u54cd\u75c5\u6bd2\u68c0\u6d4b\u3002 \u00a0<\/p>\n

Chem. Comm.:<\/b><\/strong>\u00a0<\/b><\/strong>\u542b\u955d\u7684\u4e24\u6027\u7fa7\u9178\u76d0\u7684\u6c34\u7a33\u5b9aMOFs:\u57c3\u535a\u62c9\u75c5\u6bd2RNA\u5e8f\u5217\u7684\u4f20\u611f\u5e73\u53f0<\/b><\/strong><\/p>\n

2016\u5e74\u5357\u65b9\u533b\u79d1\u5927\u5b66\u7684\u9648\u91d1\u9999\u548c\u9648\u6587\u534e<\/b><\/strong>\u4e24\u4f4d\u6559\u6388\u62a5\u544a\u4e86\u4e00\u79cd\u6c34\u7a33\u5b9a\u76843D\u955d\u57fa\u91d1\u5c5e\u6709\u673a\u6846\u67b6(MOF)\uff0c\u53ef\u4ee5\u4e0e\u63a2\u9488ss-DNA\u975e\u5171\u4ef7\u76f8\u4e92\u4f5c\u7528\u3002\u8be5\u4f53\u7cfb\u53ef\u4f5c\u4e3a\u68c0\u6d4b\u57c3\u535a\u62c9\u75c5\u6bd2\u4e92\u8865RNA\u5e8f\u5217\u7684\u6709\u6548\u8367\u5149\u4f20\u611f\u5e73\u53f0\uff0c\u68c0\u6d4b\u9650\u4e3a160 pM\u3002<\/p>\n

\"\"<\/p>\n

A water-stable metal\u2013organic framework of a zwitterionic carboxylate with dysprosium: a sensing platform for Ebolavirus RNA sequences<\/u>. <\/u>Chem. Commun., 2016,52, 132-135<\/u><\/a><\/p>\n

\u8fd9\u4e24\u7bc7\u6587\u7ae0\u5728\u672c\u8d28\u4e0a\u662f\u975e\u5e38\u4e92\u8865\u7684\uff0c\u56e0\u4e3a\u5b83\u4eec\u6e05\u695a\u5730\u8868\u660e\uff0cMOFs\u7684\u6027\u8d28\u5bf9\u603b\u4f53\u53cd\u5e94\u6709\u5f88\u5927\u7684\u5f71\u54cd\u3002\u7136\u800c\uff0c\u8fd9\u4e24\u7bc7\u6587\u7ae0\u90fd\u6ca1\u6709\u7814\u7a76\u91cd\u8981\u7684\u7ec6\u8282\uff0c\u4f8b\u5982\uff0c\u6bcf\u79cd\u591a\u91d1\u5c5e\u6c27\u5316\u7269\u7684\u6676\u4f53\u5f62\u6001(\u9897\u7c92\u5927\u5c0f\u548c\u8868\u9762\u79ef)\u5bf9\u4e0e\u6807\u8bb0\u7684DNA\u63a2\u9488\u7684\u76f8\u4e92\u4f5c\u7528\u4ee5\u53ca\u5bf9\u4f20\u611f\u673a\u5236\u7684\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u8fd9\u4e24\u4efd\u62a5\u544a\u4e2d\u6ca1\u6709\u5b54\u9699\u5ea6\u6d4b\u91cf\u503c\u3002<\/p>\n

\u524d\u4eba\u5df2\u8ff0MOFs\u662f\u591a\u529f\u80fd\u5e73\u53f0\uff0c\u9002\u7528\u4e8e\u591a\u79cd\u5206\u6790\u7269\u7684\u68c0\u6d4b\u3002\u8fd9\u79cd\u591a\u91cd\u4f5c\u7528\u5df2\u7ecf\u88ab\u5b9e\u9645\u5e94\u7528\u4e8e\u5728\u975e\u5e38\u65e9\u671f\u9636\u6bb5\u68c0\u6d4bEV\u611f\u67d3\u3002\u4f17\u6240\u5468\u77e5\uff0c\u57c3\u535a\u62c9\u75c5\u6bd2\u548c\u5176\u4ed6\u5355\u94feRNA\u75c5\u6bd2\u5bb6\u65cf\u7684\u75c5\u6bd2\u4f1a\u4ea7\u751f\u5c0f\u7684\u975e\u7f16\u7801RNA\u5e8f\u5217\uff0c\u79f0\u4e3a\u5faeRNA (miRNA)\uff0c\u5728\u975e\u5e38\u65e9\u671f\u7684\u60a3\u8005\u8840\u6db2\u4e2d\u51fa\u73b0\u3002\u56e0\u6b64\uff0cmiRNA\u548cSEV RNA\u5e8f\u5217\u7684\u53cc\u91cd\u68c0\u6d4b\u53ef\u4ee5\u5b9e\u73b0\u75be\u75c5\u7684\u51c6\u786e\u548c\u65e9\u671f\u68c0\u6d4b\uff0c\u63d0\u4f9b\u66f4\u7b80\u5355\u3001\u66f4\u5feb\u548c\u66f4\u4fbf\u5b9c\u7684\u8bca\u65ad\u5de5\u5177\u3002[Talanta 180 (2018) 396\u2013402.]\u00a0\u7136\u800c\uff0c\u5fc5\u987b\u6ce8\u610f\u7684\u662f\uff0cMOFs\u751f\u7269\u4f20\u611f\u5e73\u53f0\u4ecd\u5904\u4e8e\u65e9\u671f\u5f00\u53d1\u9636\u6bb5\uff0c\u4ec5\u4f5c\u4e3a\u8fd9\u4e00\u6982\u5ff5\u9002\u7528\u6027\u7684\u8bc1\u660e\u3002\u4e0b\u4e00\u6b65\u5b9e\u65bd\u57fa\u4e8eMOFs\u7684\u68c0\u6d4b\uff0c\u5fc5\u7136\u610f\u5473\u7740\u5c06\u5b83\u4eec\u6574\u5408\u5230\u4e00\u4e2a\u53ef\u5de5\u4f5c\u7684\u4fbf\u643a\u5f0f\u8bbe\u5907\u4e2d\uff0c\u5e76\u5728\u9009\u5b9a\u7684\u7ec4\u4ef6\u4e2d\u91cd\u65b0\u8bc4\u4f30\u5b83\u4eec\u7684\u529f\u80fd\u3002<\/p>\n

2.2 \u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2<\/b><\/strong><\/p>\n

\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2(\u827e\u6ecb\u75c5\u6bd2)\u662f\u83b7\u5f97\u6027\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u7efc\u5408\u5f81(\u827e\u6ecb\u75c5)\u7684\u75c5\u539f\u4f53\u3002\u827e\u6ecb\u75c5\u6bd2\u662f\u4e00\u79cd\u9006\u8f6c\u5f55\u75c5\u6bd2\uff0c\u5176\u9057\u4f20\u4fe1\u606f\u7531\u4e00\u6761RNA\u5355\u94fe\u7f16\u7801\u3002\u4e3a\u4e86\u590d\u5236\uff0c\u75c5\u6bd2RNA\u9700\u8981\u8f6c\u5316\u4e3a\u53cc\u94feDNA (dsDNA)\uff0c\u5e76\u901a\u8fc7\u79f0\u4e3a\u9006\u8f6c\u5f55\u7684\u8fc7\u7a0b\u6574\u5408\u5230\u611f\u67d3\u7ec6\u80de\u7684\u57fa\u56e0\u7ec4\u4e2d\u3002\u5bbf\u4e3b\u7ec6\u80de\u6574\u5408\u7684\u827e\u6ecb\u75c5\u6bd2DNA\u88ab\u79f0\u4e3a\u524d\u75c5\u6bd2DNA\uff0c\u5b83\u53ef\u4ee5\u4fdd\u6301\u6f5c\u4f0f\u6216\u88ab\u8f6c\u5f55\u4ee5\u4ea7\u751f\u65b0\u7684\u75c5\u6bd2\u9897\u7c92\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5728\u5df2\u7ecf\u63a5\u53d7\u827e\u6ecb\u75c5\u6bd2\u836f\u7269\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u5b58\u5728\u524d\u75c5\u6bd2\u8131\u6c27\u6838\u7cd6\u6838\u9178\u662f\u75c5\u6bd2\u5bf9\u6cbb\u7597\u4ea7\u751f\u8010\u836f\u6027\u7684\u826f\u597d\u6307\u6807\u3002<\/p>\n

Analyst: MOF MIL-101\u4f5c\u4e3a\u4f4e\u80cc\u666f\u4fe1\u53f7\u5e73\u53f0\u7528\u4e8e\u65e0\u6807\u8bb0DNA\u68c0\u6d4b\u7684<\/b><\/strong><\/p>\n

\u897f\u5357\u5927\u5b66\u7684\u674e\u539f\u82b3\u6559\u6388\u548c\u8d75\u5e0c\u5a1f\u526f\u6559\u6388<\/b><\/strong>\u5f15\u5165MIL-101(Cr3<\/sub>F(H2<\/sub>O)2<\/sub>O[(O2<\/sub>C)\u2013C6<\/sub>H4<\/sub>\u2014(CO2<\/sub>)]3<\/sub>\u00b7nH2<\/sub>O)\u4f5c\u4e3a\u6dec\u706d\u5e73\u53f0\uff0c\u4ee5\u964d\u4f4eSYBR Green I(SG)\/\u63a2\u9488DNA\u590d\u5408\u7269\u7684\u9ad8\u80cc\u666f\u8367\u5149\u3002\u673a\u7406\u7814\u7a76\u8868\u660e\uff0cMIL-101\u53ef\u4ee5\u901a\u8fc7\u03c0-\u03c0\u5806\u79ef\u548c\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u5f3a\u70c8\u5438\u9644SG\/\u63a2\u9488DNA\u590d\u5408\u7269\uff0c\u7ed3\u679cSG\u67d3\u6599\u7684\u8367\u5149\u88ab\u5927\u5927\u731d\u706d\u3002\u800c\u5728\u6709\u9776DNA\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0cDNA\u7684\u521d\u751f\u521a\u6027\u53cc\u94fe(ds)\u7ed3\u6784\u4f1a\u8fdc\u79bbMIL-101\u7684\u8868\u9762\uff1b\u540c\u65f6\uff0cSG\u67d3\u6599\u53ef\u4ee5\u4ee5\u5d4c\u5165\u548c\u5c0f\u51f9\u69fd\u7ed3\u5408\u7684\u65b9\u5f0f\u4e0edsDNA\u7ed3\u5408\uff0c\u5bfc\u81f4SG\u67d3\u6599\u8367\u5149\u589e\u5f3a\u3002<\/p>\n

\"\"<\/p>\n

Metal-organic framework MIL-101 as a low background signal platform for label-free DNA detection<\/u>. Analyst, 2014, 139, 801-806<\/u><\/a><\/p>\n

\u5229\u7528\u5438\u9644SYBR Green I\u7684ssDNA\u63a2\u9488\uff0c\u5c06\u5176\u4e0eMIL-101(Cr)\u7ed3\u5408\uff0c\u53ef\u6709\u6548\u68c0\u6d4bssHIV-1\u75c5\u6bd2DNA\u3002\u76ee\u6807\u5355\u94fe\u4e0e\u63a2\u9488\u5feb\u901f\u6742\u4ea4\u5f62\u6210dsDNA\u3002\u57280.1-14 nM\u8303\u56f4\u5185\uff0c\u589e\u52a0\u7684\u4fe1\u53f7\u80cc\u666f\u6bd4\u4e0e\u76ee\u6807DNA\u6d53\u5ea6\u5448\u7ebf\u6027\u5173\u7cfb\uff0cLOD\u4e3a73 pM\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5355\u78b1\u57fa\u9519\u914d\u7684\u9776DNA\u662f\u53ef\u4ee5\u7528\u975e\u5e38\u6709\u6548\u7684\u65b9\u6cd5\u9274\u522b\u7684\u3002\u4f5c\u8005\u4f7f\u7528MIL-101(Cr)\u5c06\u4fe1\u53f7\u80cc\u666f\u6bd4\u63d0\u9ad8\u4e86\u8fd18\u500d\uff0c\u8868\u660eMOF\u786e\u5b9e\u662f\u4e00\u4e2a\u6709\u6548\u7684\u4f4e\u80cc\u666f\u4fe1\u53f7\u566a\u58f0\u5e73\u53f0\uff0c\u8fdc\u4f4e\u4e8e\u57fa\u4e8e\u78b3\u7eb3\u7c73\u7ba1\u548c\u6c27\u5316\u77f3\u58a8\u70ef\u5e73\u53f0\u7684\u68c0\u6d4b\u9650\u3002<\/p>\n

2.3 \u65e5\u672c\u8111\u708e<\/b><\/strong><\/p>\n

\u65e5\u672c\u8111\u708e\u75c5\u6bd2(JEV)\u662f\u4e00\u79cd\u5355\u94fe\u6838\u7cd6\u6838\u9178\u75c5\u6bd2\uff0c\u53ef\u5bfc\u81f4\u6f5c\u5728\u7684\u81f4\u547d\u611f\u67d3\uff0c\u6b7b\u4ea1\u7387\u4e3a25-30%\u3002\u6700\u8fd1\u521a\u521a\u62a5\u9053\u4e86\u4f7f\u7528\u8868\u9762\u6539\u6027\u7684\u591a\u78fa\u9178\u7c98\u591a\u7cd6\u5bf9\u5176\u8fdb\u884c\u68c0\u6d4b\u3002\u8fd9\u4e00\u8fc7\u7a0b\u6781\u5177\u521b\u65b0\u6027\uff0c\u4e0d\u4ec5\u56e0\u4e3a\u4f7f\u7528\u4e86\u8868\u9762\u4fee\u9970\u5de5\u5177\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5b83\u53ef\u4ee5\u68c0\u6d4b\u6574\u4e2a\u75c5\u6bd2\u9897\u7c92\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u75c5\u6bd2\u7684\u9057\u4f20\u7269\u8d28\u3002\u6240\u7528\u7684MOF\u662fMIL-101(Cr)\uff0c\u5b83\u9996\u5148\u6d82\u4e0a\u4e00\u5c42\u4e8c\u6c27\u5316\u7845\uff0c\u7136\u540e\u7528\u4e00\u79cd\u53eb\u505a\u5206\u5b50\u5370\u8ff9\u7684\u6280\u672f\u7528\u4e19\u70ef\u9178\u950c\u5904\u7406\u3002\uff08\u56fe\uff09\u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u4e19\u70ef\u9178\u916f\u805a\u5408\u7269\u5728\u591a\u5b54\u8d28\u819c\u8868\u9762\u7684\u6c89\u79ef\u662f\u5728\u4f5c\u4e3a\u805a\u5408\u6a21\u677f\u7684JEV\u5168\u75c5\u6bd2\u9897\u7c92\u5b58\u5728\u4e0b\u8fdb\u884c\u7684\u3002\u53bb\u9664\u6a21\u677f\u9897\u7c92\u540e\uff0c\u52a0\u5165\u805a\u4e59\u4e8c\u9187\u4f5c\u4e3a\u5c01\u95ed\u5242\uff0c\u5c01\u95ed\u8868\u9762\u5b54\u9699\u3002\u8fd9\u4e00\u6b65\u65e8\u5728\u589e\u5f3a\u4f20\u611f\u5668\u7684\u80fd\u529b\uff0c\u7279\u522b\u662f\u8bc6\u522bJEV\u7684\u80fd\u529b\u3002\u5728JEV\u5b58\u5728\u4e0b\uff0c\u5206\u5b50\u805a\u5408\u7269\u7684\u8367\u5149\u5f3a\u5ea6\u589e\u52a0\u3002\u8fd9\u79cd\u589e\u52a0\u5728\u7edf\u8ba1\u5b66\u4e0a\u662f\u663e\u8457\u7684\uff0c\u8868\u660e\u53ef\u4ee5\u4ee5\u9ad8\u7075\u654f\u5ea6\u68c0\u6d4b\u76ee\u6807\u3002JEV\u6d53\u5ea6\u8303\u56f4\u4e3a50\u81f31400 pM\u65f6\uff0c\u8367\u5149\u589e\u5f3a\u54cd\u5e94\u5448\u7ebf\u6027\uff0c\u6700\u4f4e\u68c0\u51fa\u9650\u4ec5\u4e3a13 pM\u3002JEV\u5e73\u53f0\u7684\u7279\u5f02\u6027\u53d7\u5230\u5176\u4ed6\u75c5\u6bd2\u7684\u6311\u6218\uff0c\u5373\u7532\u578b\u809d\u708e\u75c5\u6bd2(HAV)\u3001\u9ebb\u98ce\u75c5\u75c5\u6bd2\u548c\u72c2\u72ac\u75c5\u75c5\u6bd2\uff0c\u5b83\u4eec\u7684\u8367\u5149\u5f3a\u5ea6\u8f83\u4f4e\u3002\uff08\u5982\u4e0b\u56fe\uff0c\u57fa\u4e8eMIL-101\u7684\u75c5\u6bd2\u5206\u5b50\u5370\u8ff9\u805a\u5408\u7269\u7684\u5236\u5907\u539f\u7406\u53ca\u65e5\u672c\u8111\u708e\u75c5\u6bd2(JEV)\u7684\u68c0\u6d4b\uff09<\/p>\n

\"\"<\/p>\n

2.4 \u7532\u578b\u809d\u708e<\/b><\/strong><\/p>\n

MIL-101 MOF\u88ab\u8fdb\u4e00\u6b65\u8bc1\u660e\u662f\u63a2\u6d4bHAV\u5168\u7c92\u5b50\u7684\u826f\u597d\u5e73\u53f0\u3002\u5728\u8fd9\u4efd2020\u5e741\u6708\u7684\u6700\u65b0\u62a5\u544a\u4e2d\uff0cMIL-101\u6d82\u6709\u4e00\u5c42\u5bf9pH\u503c\u654f\u611f\u7684\u805a\u5408\u7269\u2014\u2014\u7532\u57fa\u4e19\u70ef\u9178\u4e8c\u7532\u6c28\u57fa\u4e59\u916f\uff0c\u8be5\u805a\u5408\u7269\u540c\u6837\u662f\u901a\u8fc7\u5206\u5b50\u5370\u8ff9\u6280\u672f\u5236\u5907\u7684\u3002\u8fd9\u79cd\u805a\u5408\u7269\u6709HAV\u5f62\u72b6\u7684\u7a7a\u8154\uff0c\u4e13\u95e8\u7528\u4e8e\u76ee\u6807HAV\u7c92\u5b50\u3002\u68c0\u6d4b\u91c7\u7528\u4e86\u7b80\u5355\u7684\u5171\u632f\u5149\u6563\u5c04\u6280\u672f\u3002\u5f53HVA\u7c92\u5b50\u88ab\u5438\u9644\u5230\u7eb3\u7c73\u7c92\u5b50\u7684\u5206\u5b50\u5370\u8ff9\u8868\u9762\u65f6\uff0c\u5b83\u4eec\u5bfc\u81f4\u7c92\u5b50\u5c3a\u5bf8\u589e\u52a0\uff0c\u968f\u540e\u6fc0\u5149\u5171\u632f\u5149\u6563\u5c04\u5f3a\u5ea6\u589e\u52a0\u3002\u968f\u7740\u76ee\u6807HVA\u6d53\u5ea6\u7684\u589e\u52a0\uff0c\u66f4\u591a\u7684\u75c5\u6bd2\u9897\u7c92\u88ab\u5438\u9644\uff0c\u5bfc\u81f4\u4e0e\u5171\u632f\u5149\u6563\u5c04\u5f3a\u5ea6\u7684\u76f8\u5173\u6027\u3002\u5728470 nm\u7684\u5de5\u4f5c\u6ce2\u957f\u4e0b\uff0c\u89c2\u5bdf\u5230\u6d53\u5ea6\u57280.02\u81f32.0 nM\u4e4b\u95f4\u7684\u7ebf\u6027\u5242\u91cf-\u53cd\u5e94\u76f8\u5173\u6027\u3002\u5e73\u53f0\u7684LOD\u6781\u4f4e\uff0c\u4e3a0.1 pM\uff0c\u54cd\u5e94\u65f6\u95f4\u4e3a20\u5206\u949f\u3002[Microchim. Acta.2020,\u00a0187,140]\uff08\u5982\u4e0b\u56fe\uff0c\u7528\u4e8e\u68c0\u6d4b\u7532\u578b\u809d\u708e\u75c5\u6bd2\u7684\u5206\u5b50\u5370\u8ff9\u7eb3\u7c73\u63a2\u9488\u7684\u5236\u5907\u793a\u610f\u56fe(HVA)\uff09<\/p>\n

\"\"<\/p>\n

3. \u603b\u7ed3<\/b><\/strong><\/p>\n

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\u63a8\u8350\u6587\u732e\uff1a<\/p>\n

[1] J.Y. Yang et al., A novel fluorescence molecularly imprinted sensor for Japanese encephalitis virus detection based on metal organic frameworks and passivation-enhanced selectivity. Talanta 212 (2020) 120744.<\/p>\n

[2] L.H. Luo et al., Molecular imprinting resonance light scattering nanoprobes based on pH-responsive metal-organic framework for determination of hepatitis A virus. Microchim. Acta 187 (2020) 140<\/p>\n

[3] H. Huang et al., COVID-19: A Call for Physical Scientists and Engineers. ACS Nano 14 (2020) 3747\u20133754.<\/p>\n

[4] J. Yang, Y.-W. Yang, Metal\u2013Organic Frameworks for Biomedical Applications. Small 16 (2020) 1906846.<\/p>\n

[5] L. Jiao et al., Metal\u2013organic frameworks: Structures and functional applications. Mater. Today 27 (2019) 43\u201368.<\/p>\n

[6] ] Q. Qiu et al., Recent advances in the rational synthesis and sensing applications of metal-organic framework biocomposites. Coord. Chem. Rev. 387 (2019) 60\u201378.<\/p>\n

[7]\u00a0D.I. Osman et al., Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis. Biosens. Bioelectron. 141 (2019) 111451.<\/p>\n

\u672c\u6587\u7531\u7eb3\u7c73\u5c0f\u767d\u4f9b\u7a3f\u3002<\/p>\n

\u672c\u5185\u5bb9\u4e3a\u4f5c\u8005\u72ec\u7acb\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u6750\u6599\u4eba\u7f51\u7acb\u573a\u3002<\/p>\n

\u672a\u7ecf\u5141\u8bb8\u4e0d\u5f97\u8f6c\u8f7d\uff0c\u6388\u6743\u4e8b\u5b9c\u8bf7\u8054\u7cfbkefu@cailiaoren.com\u3002<\/p>\n

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