{"id":221143,"date":"2021-05-02T06:48:38","date_gmt":"2021-05-01T22:48:38","guid":{"rendered":"\/\/m.iemloyee.com\/?p=221143"},"modified":"2021-05-01T21:48:54","modified_gmt":"2021-05-01T13:48:54","slug":"angew-chem-int-ed-%ef%bc%9a%e6%b6%88%e7%81%ad%e7%99%8c%e7%bb%86%e8%83%9e%ef%bc%8c%e7%9b%b4%e6%8e%a5%e6%8d%95%e8%8e%b7%e8%83%9e%e5%86%85%e8%87%b4%e7%99%8c%e6%80%a7microrna%ef%bc%81","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=221143","title":{"rendered":"Angew. Chem. Int. Ed.\uff1a\u6d88\u706d\u764c\u7ec6\u80de\uff0c\u76f4\u63a5\u6355\u83b7\u80de\u5185\u81f4\u764c\u6027microRNA\uff01"},"content":{"rendered":"<p><strong>\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n<p>\u5728\u81ea\u7136\u754c\u4e2d\uff0c\u5404\u79cd\u975e\u7f16\u7801RNA\u901a\u8fc7\u7ed3\u5408\u548c\u6291\u5236\u5176\u4ed6\u7f16\u7801\u6216\u8c03\u63a7RNA\u5728\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u5b83\u4eec\u901a\u5e38\u4f1a\u8fdb\u5316\u51fa\u7279\u522b\u7684\u7ed3\u6784\u914d\u7f6e\uff0c\u4ee5\u786e\u4fdd\u5176\u5728\u751f\u547d\u7cfb\u7edf\u4e2d\u7684\u529f\u80fd\u3002\u4f8b\u5982\uff0cmicroRNAs\uff08miRNAs\uff09\u9700\u8981\u4e0eArgonaute\uff08Ago\uff09\u86cb\u767d\u7ed3\u5408\uff0c\u5f62\u6210\u6838\u7cd6\u6838\u86cb\u767d\uff0c\u5373\u6240\u8c13\u7684RNA\u8bf1\u5bfc\u6c89\u9ed8\u590d\u5408\u7269\uff08RISC\uff09\uff0c\u5b83\u53ef\u4ee5\u7ed3\u5408\u5e76\u6291\u5236mRNA\u3002\u800c\u73af\u5f62RNA\uff08cirRNAs\uff09\u4f5c\u4e3a\u81ea\u7136\u754c\u4e2d\u6709\u6548\u7684miRNA\u6d77\u7ef5\uff0c\u5177\u6709\u5c01\u95ed\u7684\u62d3\u6251\u7ed3\u6784\uff0c\u53ef\u4ee5\u589e\u5f3a\u5176\u62b5\u6297\u4f53\u5185\u9176\u4fc3\u964d\u89e3\u7684\u7a33\u5b9a\u6027\u3002\u5c06\u5916\u6e90\u975e\u7f16\u7801\u6838\u9178\u76f4\u63a5\u9012\u9001\u5230\u6d3b\u7ec6\u80de\u4e2d\u5df2\u7ecf\u5f15\u8d77\u4e86\u751f\u7269\u5b66\u5e94\u7528\u7684\u5f3a\u70c8\u5174\u8da3\u3002\u7136\u800c\uff0c\u7ec6\u80de\u8fdb\u5165\u6548\u7387\u548c\u9776\u6807\u6355\u83b7\u80fd\u529b\u4ecd\u6709\u5f85\u63d0\u9ad8\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u53d8\u9769\u6027\u5206\u5b50\u524d\u6cbf\u79d1\u5b66\u4e2d\u5fc3\u738b\u98de\u526f\u6559\u6388\u56e2\u961f<\/strong>\u5f00\u53d1\u4e86\u4e00\u79cd\u5206\u5272\u591a\u805a\u817a\u560c\u5464\u4e3a\u7403\u5f62\u6838\u9178\uff08polyA-SNAs\uff09\u7684\u65b9\u6cd5\uff0c\u4ee5\u6709\u6548\u6355\u83b7\u6d3b\u7ec6\u80de\u4e2d\u7684\u81f4\u764c\u6027microRNA\uff08miRNA\uff09\u3002\u7814\u7a76\u53d1\u73b0\uff0cpolyA-SNAs\u8868\u73b0\u51fa\u8f83\u9ad8\u7684\u7ec6\u80de\u6444\u53d6\u6548\u7387\uff0c\u5bf9\u6297miRNA\u5e8f\u5217\u7684\u7ed3\u6784\u4e0d\u654f\u611f\u3002\u901a\u8fc7\u7f16\u7a0bpolyA\u7684\u957f\u5ea6\uff0c\u4f5c\u8005\u53ef\u4ee5\u7cbe\u786e\u5730\u8bbe\u8ba1polyA-SNA\u4e2d\u6297miRNA\u5e8f\u5217\u7684\u7a7a\u95f4\u7ed3\u6784\u3002\u4e0e\u5bc6\u96c6\u7d27\u5b9e\u7684SNAs\u76f8\u6bd4\uff0c\u95f4\u9694\u5316\u7684polyA-SNA\u4e0emiRNAs\u7ed3\u5408\u5177\u6709\u66f4\u5f3a\u7684\u6355\u83b7\u80fd\u529b\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8bc1\u660e\uff0cpolyA-SNAs\u53ef\u4f5c\u4e3a\u9ad8\u6548\u7684miRNA\u6d77\u7ef5\uff0c\u7528\u4e8e\u6355\u83b7\u6d3b\u7ec6\u80de\u548c\u5c0f\u9f20\u4f53\u5185\u7684\u81f4\u764c\u6027miRNA\u3002\u901a\u8fc7\u5bf9miRNA\u7684\u6709\u6548\u6355\u83b7\u53ef\u663e\u8457\u6291\u5236\u4f53\u5185\u5916\u80bf\u7624\u7684\u751f\u957f\u3002\u8be5\u8bba\u6587\u4ee5\u9898\u4e3a\u201c<strong>Compartmenting poly-adenine-based spherical nucleic acids for efficient live-cell microRNA capture<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520a<strong>Angew. Chem. Int. Ed.<\/strong>\u4e0a\uff0c\u7126\u51ef\u3001\u95eb\u5e86\u9f99\u3001\u90ed\u7433\u6d01\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u5177\u6709\u4e0d\u540c<\/strong><strong>polyA<\/strong><strong>\u957f\u5ea6\u7684<\/strong><strong>PolyA-SNAs<\/strong><strong>\u8868\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-221145\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/1-20.jpg\" alt=\"\" width=\"600\" height=\"555\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/1-20.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/1-20-300x278.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09DNA\u94fe\u5bc6\u5ea6\u5bf9polyA\u957f\u5ea6\u4f9d\u8d56\u5173\u7cfb\u7684\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08b\uff09polyA-SNAs\u7684TEM\u56fe\u50cf\u3002<\/p>\n<p>\uff08c\uff09\u4e0d\u540cpolyA\u957f\u5ea6\u7684SNAs\u4e0a\u6bcf\u4e2a\u7c92\u5b50DNA\u94fe\u6570\u91cf\u7684\u91cf\u5316\u3002<\/p>\n<p>\uff08d\uff09\u901a\u8fc7DLS\u8868\u5f81\u7684SNAs\u7684\u6c34\u5408\u76f4\u5f84\u3002<\/p>\n<p><strong>\u56fe\u4e8c\u3001\u6355\u83b7\u5177\u6709\u7a7a\u95f4\u4f4d\u963b\u7684<\/strong><strong>mir21<\/strong><strong>\u9776\u70b9\u7684\u80fd\u529b<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-221146\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/2-19.jpg\" alt=\"\" width=\"600\" height=\"490\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/2-19.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/2-19-300x245.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u5229\u7528DNA-AuNPs\u6a21\u62df\u5177\u6709\u7a7a\u95f4\u4f4d\u963b\u7684\u9776\u70b9\u7684\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08b\uff09\u53cd\u6620\u6297mir21 SNAs\u6355\u83b7\u80fd\u529b\u7684\u4ee3\u8868\u6027TEM\u56fe\u50cf\u548c\u7edf\u8ba1\u6570\u636e\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001<\/strong><strong>polyA-SNAs<\/strong><strong>\u7684\u7ec6\u80de\u6444\u53d6\u548c\u80de\u5185<\/strong><strong>miRNA<\/strong><strong>\u6355\u83b7<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-221147\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/3-19.jpg\" alt=\"\" width=\"600\" height=\"382\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/3-19.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/3-19-300x191.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u7528polyA-SNAs\u5904\u7406\u7684293T\u7ec6\u80de\u7684\u6697\u573a\u663e\u5fae\u56fe\u50cf\u3002<\/p>\n<p>\uff08b\uff09ICP-MS\u5b9a\u91cf\u6d4b\u5b9a\u6bcf\u4e2a293T\u7ec6\u80de\u4e2dAuNP\u7684\u6570\u91cf\u3002<\/p>\n<p>\uff08c\uff09\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790polyA-SNAs\u5728293T\u7ec6\u80de\u4e2d\u7684mir21\u6355\u83b7\u80fd\u529b\u3002<\/p>\n<p>\uff08d\uff09\u7ecfpolyA-SNAs\u5904\u7406\u7684293T\u7ec6\u80de\u4e2d\u672a\u7ed3\u5408mir21\u7684RT-qPCR\u5206\u6790\u3002<\/p>\n<p><strong>\u56fe\u56db\u3001\u901a\u8fc7<\/strong><strong>polyA-SNA<\/strong><strong>\u62ef\u6551\u6297\u764c\u57fa\u56e0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-221148\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/4-18.jpg\" alt=\"\" width=\"600\" height=\"418\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/4-18.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/4-18-300x209.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09polyA-SNA\u62ef\u6551EGFP\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08b\uff09\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790polyA-SNAs\u5bf9293T\u7ec6\u80deEGFP-R\u8868\u8fbe\u7684\u5f71\u54cd\u3002<\/p>\n<p>\uff08c\uff09\u7528polyA-SNAs\u5904\u7406MCF7\u7ec6\u80de\u540emir21\u8868\u8fbe\u7684RT-qPCR\u5206\u6790\u3002<\/p>\n<p>\uff08d\uff09\u4e0epolyA-SNAs\u6216\u6307\u5b9a\u5bf9\u7167\u5b75\u80b2\u540eMCF-7\u7ec6\u80de\u4e2dTPM1\u7684\u86cb\u767d\u8868\u8fbe\u3002<\/p>\n<p>\uff08e\uff09\u76f8\u540c\u6d53\u5ea6\u7684polyA-SNAs\u4f38\u51fa\u6297mir21\u5e8f\u5217\u6216\u968f\u673a\u5e8f\u5217\u8bf1\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n<p><strong>\u56fe\u4e94\u3001<\/strong><strong>polyA-SNAs<\/strong><strong>\u5f15\u8d77\u7684\u80bf\u7624\u751f\u957f\u6291\u5236<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-221149\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/5-13.jpg\" alt=\"\" width=\"600\" height=\"474\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/5-13.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/5-13-300x237.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u5c0f\u9f20\u5b9e\u9a8c\u6d41\u7a0b\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08b\uff09\u7624\u5185\u6ce8\u5c04Cy5.5\u6807\u8bb0\u7684polyA-SNAs\u548c\u6e38\u79bb\u7684\u6297mir21\u5e8f\u5217\u540e\u5c0f\u9f20MCF-7\u80bf\u7624\u7684\u8367\u5149\u56fe\u50cf\u548c\u8367\u5149\u7edf\u8ba1\u3002<\/p>\n<p>\uff08c\uff09\u6ce8\u5c04\u540e26\u5929\u7684\u80bf\u7624\u4f53\u79ef\u53d8\u5316\u52a8\u6001\u3002<\/p>\n<p>\uff08d\uff09\u6240\u793a\u5404\u7ec4\u5c0f\u9f20\u80bf\u7624\u7684\u4ee3\u8868\u6027\u56fe\u7247\u548c\u5e73\u5747\u91cd\u91cf\u3002<\/p>\n<p>\uff08e\uff09polyA-SNAs\u6cbb\u7597\u524d\u540e\u8377\u7624\u5c0f\u9f20\u4f53\u91cd\u7684\u53d8\u5316\u3002<\/p>\n<p><strong>\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u62a5\u9053\u4e86\u4e00\u79cd\u65b0\u7684\u57fa\u4e8epolyA\u7a0b\u5e8f\u5316SNAs\u7684miRNA\u6291\u5236\u7b56\u7565\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u4e0e\u5176\u4ed6\u7ed3\u6784\u76f8\u6bd4\uff0c\u5728\u9002\u5f53\u7684polyA\u957f\u5ea6\u4e0b\uff0cSNAs\u53ef\u4ee5\u83b7\u5f97\u66f4\u9ad8\u7684miRNA\u6355\u83b7\u6548\u7387\u3002\u4f5c\u8005\u8bc1\u660e\u8be5\u7cfb\u7edf\u53ef\u4ee5\u5e94\u7528\u4e8e\u4f53\u5185\uff0c\u6709\u6548\u6291\u5236\u81f4\u764c\u6027miRNA mir21\uff0c\u62ef\u6551\u6291\u764c\u57fa\u56e0TPM1\uff0c\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u8fd9\u79cdpolyA-SNA\u7cfb\u7edf\u6709\u51e0\u4e2a\u4f18\u70b9\u30021\uff09SNA\u8868\u9762\u6297miRNA\u94fe\u7684\u6784\u8c61\u548c\u4fa7\u5411\u95f4\u8ddd\u53ef\u4ee5\u901a\u8fc7polyA\u957f\u5ea6\u6765\u8c03\u8282\uff0c\u4ece\u800c\u4f18\u5316\u5176\u4e0emiRNA-Ago\u590d\u5408\u7269\u7684\u6355\u83b7\u80fd\u529b\uff1b2\uff09polyA-SNAs\u4e0e\u5176\u4ed6\u5bc6\u96c6\u578bSNAs\u76f8\u6bd4\u5177\u6709\u8f83\u9ad8\u7684\u7ec6\u80de\u8fdb\u5165\u6548\u7387\u3002\u56e0\u6b64\uff0c\u7ec6\u80de\u8fdb\u5165\u548c\u9776\u5411\u6355\u83b7\u6548\u7387\u4e4b\u95f4\u7684\u51b2\u7a81\u53ef\u4ee5\u5f97\u5230\u5f88\u5927\u7a0b\u5ea6\u7684\u89e3\u51b3\uff0c\u4ece\u800c\u80fd\u591f\u5728\u7ec6\u80de\/\u4f53\u5185\u6709\u6548\u5730\u4f20\u9012\u548c\u53d1\u6325\u4f5c\u7528\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u4e00\u4e9b\u5229\u7528\u7eafDNA\u7ed3\u6784\u4f5c\u4e3a\u8f7d\u4f53\u7684\u7b56\u7565\u4ecd\u7136\u5b58\u5728\u7ec6\u80de\u8fdb\u5165\u6548\u7387\u4f4e\u4e0b\u7684\u95ee\u9898\uff0c\u9700\u8981\u8f6c\u67d3\u8bd5\u5242\uff1b3\uff09SNAs\u7684\u76f4\u63a5\u9012\u9001\u907f\u514d\u4e86\u9633\u79bb\u5b50\u8f7d\u4f53\u6216\u75c5\u6bd2\u8f7d\u4f53\u7684\u4f7f\u7528\uff0c\u4ece\u800c\u51cf\u8f7b\u4e86\u5bf9\u6bd2\u6027\u3001\u6301\u7eed\u8868\u8fbe\u6216\u5bbf\u4e3b\u57fa\u56e0\u7ec4\u7a81\u53d8\u7684\u62c5\u5fe7\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u671f\u671b\u6b64\u7b56\u7565\u53ef\u5bb9\u6613\u5730\u9002\u7528\u4e8e\u9012\u9001\u5176\u5b83\u5916\u6e90\u5408\u6210\u7684\u529f\u80fd\u6838\u9178\uff08\u4f8b\u5982\uff0cRNA\u63a2\u9488\u3001\u5c0f\u5e72\u6270RNA\uff09\u4ee5\u7528\u4e8e\u5305\u62ec\u5206\u5b50\u8bc6\u522b\u548c\u8868\u89c2\u9057\u4f20\u5b66\u6cbb\u7597\u7684\u5e94\u7528\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.202017039\" target=\"_blank\" rel=\"noopener\">Compartmenting poly\u2010adenine\u2010based spherical nucleic acids for efficient live\u2010cell microRNA capture<\/a> (<em>Angew. Chem. Int. Ed. <\/em><strong>2021<\/strong>, DOI: 10.1002\/anie.202017039)<\/p>\n<p>\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1a<a href=\"mailto:tougao@cailiaoren.com\">tougao@cailiaoren.com<\/a><\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u7814\u7a76\u80cc\u666f\u3011 \u5728\u81ea\u7136\u754c\u4e2d\uff0c\u5404\u79cd\u975e\u7f16\u7801RNA\u901a\u8fc7\u7ed3\u5408\u548c\u6291\u5236\u5176\u4ed6\u7f16\u7801\u6216\u8c03\u63a7RNA\u5728\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u5b83\u4eec\u901a\u5e38\u4f1a\u8fdb\u5316\u51fa\u7279\u522b\u7684\u7ed3\u6784\u914d\u7f6e\uff0c\u4ee5\u786e\u4fdd\u5176\u5728\u751f\u547d\u7cfb\u7edf\u4e2d\u7684&#8230;<\/p>\n","protected":false},"author":1004,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-221143","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/221143"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1004"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=221143"}],"version-history":[{"count":5,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/221143\/revisions"}],"predecessor-version":[{"id":221461,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/221143\/revisions\/221461"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=221143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=221143"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=221143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}