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\u5f15\u8a00<\/strong><\/p>\n

\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5229\u7528\u60a3\u8005\u7684\u514d\u75ab\u7cfb\u7edf\u6740\u4f24\u6216\u6839\u9664\u80bf\u7624\uff0c\u662f\u514b\u670d\u764c\u75c7\u8f6c\u79fb\u548c\u590d\u53d1\u7684\u91cd\u8981\u4e34\u5e8a\u624b\u6bb5\u3002\u4f5c\u4e3a\u8fd1\u5e74\u6765\u5feb\u901f\u53d1\u5c55\u7684\u4e00\u79cd\u4e3b\u52a8\u578b\u7597\u6cd5\uff0c\u6cbb\u7597\u6027\u764c\u75c7\u75ab\u82d7\u901a\u8fc7\u6574\u5408\u6297\u539f\u548c\u514d\u75ab\u4f50\u5242\uff0c\u6709\u671b\u589e\u5f3a\u6297\u539f\u514d\u75ab\u539f\u6027\uff0c\u5e76\u534f\u8c03\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u4ea7\u751f\u80bf\u7624\u7279\u5f02\u6027\u5e94\u7b54\u3002\u5229\u7528\u7eb3\u7c73\u4f53\u7cfb\u8c03\u63a7\u75ab\u82d7\u7684\u751f\u7406\u547d\u8fd0\u63d0\u9ad8\u4e86\u514d\u75ab\u5e94\u7b54\u7684\u65b9\u5411\u6027\u548c\u7cbe\u786e\u6027\uff0c\u53d1\u5c55\u66f4\u4e3a\u6709\u6548\u548c\u53ef\u63a7\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u5982\u7eb3\u7c73\u75ab\u82d7\u8bbe\u8ba1\u4e0e\u5e94\u7528\u3002\u800c\u7eb3\u7c73\u6750\u6599\u7684\u4e95\u55b7\u5f0f\u53d1\u5c55\u4fc3\u8fdb\u4e86\u76f8\u5173\u75ab\u82d7\u4f53\u7cfb\u8bbe\u8ba1\u7684\u591a\u6837\u6027\u548c\u590d\u6742\u6027\uff0c\u6709\u52a9\u4e8e\u6539\u8fdb\u75ab\u82d7\u5b89\u5168\u6027\u548c\u6548\u529b\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u4e00\u4e9b\u7eb3\u7c73\u6750\u6599\u4e0e\u4f53\u5185\u514d\u75ab\u7cfb\u7edf\u76f8\u4e92\u4f5c\u7528\u540e\u4f1a\u8bf1\u53d1\u514d\u75ab\u6fc0\u6d3b\u6548\u5e94\uff0c\u5982\u63d0\u9ad8\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u7684\u6210\u719f\u3001\u6d3b\u5316\u4ee5\u53ca\u6297\u539f\u5c55\u793a\u7b49\uff0c\u8fd9\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u4e86\u57fa\u4e8e\u7eb3\u7c73\u6750\u6599\u6240\u56fa\u6709\u7684\u514d\u75ab\u6027\u8d28\u5f00\u53d1\u4e0e\u5e94\u7528\uff0c\u5982\u7eb3\u7c73\u4f50\u5242\u3002\u5c3d\u7ba1\u4e00\u4e9b\u7814\u7a76\u62a5\u9053\u4e86\u7eb3\u7c73\u6750\u6599\u7684\u4f50\u5242\u6027\u8d28\u548c\u5e94\u7528\u524d\u666f\uff0c\u4f46\u662f\u4eba\u4eec\u4ecd\u7136\u6e34\u6c42\u4e00\u79cd\u96c6\u5f3a\u5927\u7684\u4f50\u5242\u6027\u3001\u4f18\u5f02\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3001\u751f\u7269\u964d\u89e3\u6027\u548c\u591a\u79cd\u514d\u75ab\u589e\u5f3a\u673a\u5236\u4e8e\u4e00\u4f53\u7684\u7406\u60f3\u578b\u4f50\u5242\uff0c\u5176\u6709\u671b\u8fdb\u4e00\u6b65\u6269\u5145\u5e76\u4f18\u5316\u76f8\u5173\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n

\u6210\u679c\u7b80\u4ecb<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5728\u6e05\u534e\u5927\u5b66\u674e\u8273\u6885\u6559\u6388<\/b><\/strong>\u548c\u4e2d\u79d1\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u55bb\u5b66\u950b\u7814\u7a76\u5458<\/b><\/strong>\u5e26\u9886\u4e0b\uff0c\u7814\u7a76\u56e2\u961f\u6df1\u5165\u7814\u7a76\u4e86\u9ed1\u78f7\u7eb3\u7c73\u7247\uff08BPs\uff09\u7684\u7eb3\u7c73\u4f50\u5242\u6027\u8d28\u548c\u6cbb\u7597\u5e94\u7528\u524d\u666f\u3002\u56e2\u961f\u7b5b\u9009\u5f97\u5230\u7684\u82ef\u4e19\u6c28\u9178-\u8d56\u6c28\u9178-\u82ef\u4e19\u6c28\u9178\uff08FKF\uff09\u7247\u6bb5\u53ef\u63d0\u5347\u5176\u5171\u4ef7\u4fee\u9970\u7684\u6297\u539f\u80bd\uff08OVAp\uff09\u4e0eBP\u7684\u9ad8\u6548\u8d1f\u8f7d\u3002\u5176\u7ec4\u88c5\u590d\u5408\u7269FKF-OVAp@BP\u6784\u6210\u4e86\u4e00\u79cd\u6781\u7b80\u7684\u75ab\u82d7\u4f53\u7cfb\uff0c\u65e0\u9700\u6dfb\u52a0\u989d\u5916\u7ec4\u5206\uff0cBP\u80fd\u591f\u589e\u5f3a\u6811\u7a81\u7ec6\u80de\uff08DC\uff09\u7684\u6210\u719f\u3001\u6297\u539f\u6444\u53d6-\u91ca\u653e-\u6297\u539f\u5448\u9012\u4ee5\u53ca\u6dcb\u5df4\u8fd0\u8f93\u3002\u7cfb\u7edf\u6027\u76ae\u4e0b\u514d\u75ab\u53ef\u663e\u8457\u589e\u5f3a\u5c0f\u9f20\u813e\u810f\u4e0e\u80bf\u7624\u5185\u7684\u6297\u539f\u7279\u5f02\u6027CD8+<\/sup>\u00a0T\u7ec6\u80de\u7684\u6d3b\u5316\u4e0e\u6740\u4f24\uff0c\u8fdb\u4e00\u6b65\u6291\u5236\u80bf\u7624\u751f\u957f\u5e76\u5ef6\u957f\u5c0f\u9f20\u5b58\u6d3b\u7387\u3002\u7624\u5185\u539f\u4f4d\u514d\u75ab\u540c\u6837\u80fd\u591f\u4ea7\u751f\u7279\u5f02\u6027\u7684\u6297\u80bf\u7624\u5e94\u7b54\uff1b\u540c\u65f6\uff0cBP\u7684\u9ad8\u6548\u5149\u70ed\u8f6c\u5316\u6027\u8d28\u53ef\u5b9e\u73b0\u8fd1\u7ea2\u5916(NIR)\u4ecb\u5bfc\u7684\u539f\u4f4d\u6e29\u548c\u70ed\u751f\u6210\uff0c\u4fc3\u8fdb\u80bf\u7624\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u7684\u6539\u5584\uff0c\u5982\u63d0\u9ad8\u6d3b\u5316DC\u7684\u6bd4\u4f8b\u548c\u589e\u5f3aT\u7ec6\u80de\u6548\u5e94\u6027\u7b49\u3002\u6b64\u5916\uff0c\u5149\u70ed\u4fc3\u8fdb\u4e0b\u7684\u7624\u5185\u539f\u4f4d\u514d\u75ab\u4e5f\u5927\u5927\u63d0\u9ad8\u4e86\u813e\u810f\u4e2d\u8bb0\u5fc6\u7ec6\u80de\u5e94\u7b54\uff0c\u4fc3\u8fdb\u4e86\u957f\u6548\u7684\u514d\u75ab\u76d1\u67e5\u3002NIR\u4fc3\u8fdb\u7684BP\u7eb3\u7c73\u75ab\u82d7\u8fdb\u4e00\u6b65\u534f\u540c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\uff08anti-PD-L1\u5355\u6297\uff09\u5b9e\u73b0\u5f3a\u529b\u7684\u6cbb\u7597\u4f5c\u7528\uff0c\u5177\u6709\u91cd\u8981\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u3002\u8be5\u5de5\u4f5c\u63a2\u7a76\u4e86\u6574\u5408\u578b\u3001\u591a\u529f\u80fd\u5316\u7eb3\u7c73\u4f50\u5242\u6750\u6599\u53ef\u7528\u4e8e\u7b80\u5316\u4f46\u9ad8\u6548\u7684\u7eb3\u7c73\u514d\u75ab\u6cbb\u7597\uff0c\u4e3a\u4e4b\u540e\u7684\u7eb3\u7c73\u4f50\u5242\u62d3\u5c55\u63d0\u4f9b\u4e86\u91cd\u8981\u57fa\u7840\u548c\u5408\u7406\u65b9\u6848\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201cBlack phosphorous nanosheet: A novel immune-potentiating nanoadjuvant for near-infrared-improved immunotherapy<\/b><\/strong>\u201d\u53d1\u8868\u5728\u751f\u7269\u6750\u6599\u9886\u57df\u9876\u7ea7\u671f\u520aBiomaterials<\/b><\/strong>\u4e0a\u3002\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005\u4e3a\u6e05\u534e\u5927\u5b66\u5316\u5b66\u7cfb\u7684\u535a\u58eb\u751f\u674e\u6587\u6d69\u3002<\/p>\n

\u56fe\u6587\u5bfc\u8bfb<\/strong><\/p>\n

Scheme\u00a01. \u9ed1\u78f7\u7eb3\u7c73\u7247(BPs)\u53ef\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u7eb3\u7c73\u4f50\u5242\u6750\u6599\u7528\u4e8e\u75ab\u82d7\u8bbe\u8ba1<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09\u7cfb\u7edf\u514d\u75ab\u7684BP\u7eb3\u7c73\u75ab\u82d7\u53ef\u89e6\u53d1\u4e00\u7cfb\u5217\u6297\u539f\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u5176\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u534f\u540c\u4fc3\u8fdb\u80bf\u7624\u6cbb\u7597\u3002<\/p>\n

b\uff09\u5c40\u90e8\u514d\u75ab\u7684BP\u7eb3\u7c73\u75ab\u82d7\u53ef\u5229\u7528BP\u4ecb\u5bfc\u7684NIR\u6548\u5e94\u4ea7\u751f\u6e29\u548c\u7684\u5c40\u90e8\u70ed\uff0c\u4f18\u5316\u7624\u5185\u514d\u75ab\u542f\u52a8\u5e76\u4fc3\u8fdb\u7cfb\u7edf\u6027T\u7ec6\u80de\u589e\u6b96\uff0c\u5e76\u589e\u5f3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n

Figure\u00a01. \u9ed1\u78f7\u7eb3\u7c73\u7247(BPs)\u53ef\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u6548\u7684\u6297\u539f\u8d1f\u8f7d\u5e73\u53f0<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09FKF-OVAp@BP\u7684\u5236\u5907\u6d41\u7a0b\u53caBP\u8d1f\u8f7d\u7247\u6bb5\u7b5b\u9009\u793a\u610f\u56fe<\/p>\n

b\uff09HPLC\u6d4b\u5b9a\u4e0d\u540c\u4fee\u9970\u7684\u6297\u539f\u80bd\u5728BP\u8d1f\u8f7d\u524d\u540e\u4e0a\u6e05\u7684\u542b\u91cf<\/p>\n

c\uff09FKF-OVAp@BP\u7684\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u56fe<\/p>\n

d\uff09FKF-OVAp@BP\u7684\u539f\u5b50\u529b\u663e\u5fae\u955c\u56fe<\/p>\n

e\uff09HPLC\u5b9a\u91cfFKF-OVAp\u5728BP\u4e0a\u7684\u8d1f\u8f7d\u91cf<\/p>\n

f\uff09BP\u8d1f\u8f7d\u524d\u540e\u7684\u7ea2\u5916\u53ef\u89c1\u5438\u6536\u5149\u8c31<\/p>\n

Figure\u00a02. BP\u4fc3\u8fdb\u6297\u539f\u6444\u53d6\u4ee5\u53ca\u672a\u6210\u719f\u9aa8\u9ad3\u6765\u6e90\u6811\u7a81\u7ec6\u80de\uff08BMDC\uff09\u7684\u5e7f\u6cdb\u514d\u75ab\u6fc0\u6d3b<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790BMDC\u5bf9BP\u8d1f\u8f7d\u524d\u540e\u7684\u8367\u5149\u6807\u8bb0\u6297\u539f\u80bd\uff08TMR-FKF-OVAp\uff09\u7684\u6444\u53d6<\/p>\n

b\uff09\u5171\u805a\u7126\u663e\u5fae\u56fe\u7247\u5c55\u793aTMR-FKF-OVAp\u5728BMDC\u4e2d\u7684\u5b9a\u4f4d\u53ca\u542b\u91cf<\/p>\n

c\uff09\u6297\u539f\u80bd-\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269\u5728BMDC\u4e2d\u7684\u5448\u9012\u60c5\u51b5<\/p>\n

d\uff09\u5448\u9012\u6297\u539f\u7684BMDC\u7684\u6bd4\u4f8b<\/p>\n

e\uff09BP\u5904\u7406\u524d\u540eBMDC\u8868\u9762\u7684\u6d3b\u5316\u6807\u5fd7\u7269\u53d8\u5316\u53ca\u5206\u6790<\/p>\n

f-h\uff09ELISA\u6d4b\u5b9aBP\u4e0eBMDC\u5b75\u80b224 h\u540e\u4e0a\u6e05\u7684\u7ec6\u80de\u56e0\u5b50\u542b\u91cf\uff1af\uff09TNF-\u03b1\uff0cg\uff09IL-12p70\uff0ch\uff09IL-1\u03b2<\/p>\n

Figure\u00a03. BP\u662f\u4e00\u79cd\u53cc\u6548\u5e73\u53f0\uff0c\u4e0d\u4ec5\u4f18\u5316\u6297\u539f\u9012\u9001\uff0c\u5e76\u4e14\u6fc0\u6d3b\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de(CTL)\u53cd\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

a-b\uff09\u5c0f\u9f20\u6d3b\u4f53\u8367\u5149\u6210\u50cf\uff08IVIS\uff09\u6d4b\u5b9aBP\u4f5c\u7528\u4e0b\u6297\u539f\u7684\u6dcb\u5df4\u8fd0\u8f93\u53ca\u5176\u5b9a\u91cf<\/p>\n

c-f\uff09\u5c0f\u9f20\u76ae\u4e0b\u6ce8\u5c04\u768448 h\u540e\uff0c\u6dcb\u5df4\u7ed3\u5185\u529f\u80fd\u578bDC\u542b\u91cf\u5206\u6790\uff1ac\uff09\u5448\u9012\u6297\u539f\u7684DC\uff0cd\uff09\u6d3b\u5316\u7684DC\uff0ce\uff09\u6dcb\u5df4\u8fc1\u79fb\u578bDC\uff0cf\uff09\u5448\u9012\u6297\u539f\u7684\u8fc1\u79fb\u578bDC<\/p>\n

g\uff09\u5c0f\u9f20\u7684\u514d\u75ab\u6d41\u7a0b<\/p>\n

h-i\uff09\u6297\u539f\u7279\u5f02\u6027CD8+<\/sup>\u00a0T\u7ec6\u80de\u6c34\u5e73\u53d8\u5316\u53ca\u5b9a\u91cf\u5206\u6790<\/p>\n

j-l\uff09\u813e\u810f\u5185\u514d\u75ab\u7ec6\u80de\u6c34\u5e73\u53d8\u5316\uff1aj\uff09CD8+ <\/sup>T\u7ec6\u80de\uff0ck\uff09\u6d3b\u5316\u7684DC\uff0cl\uff09DC\u7684\u542b\u91cf\u53d8\u5316<\/p>\n

m-n\uff09ELISPOT\u6d4b\u5b9a\u6297\u539f\u518d\u523a\u6fc0\u540e\u813e\u810f\u7ec6\u80de\u7684\u6297\u539f\u7279\u5f02\u6027\u54cd\u5e94\u53ca\u5b9a\u91cf\u7edf\u8ba1<\/p>\n

o\uff09\u6297\u539f\u518d\u523a\u6fc0\u540e\u813e\u7ec6\u80de\u7684\u589e\u6b96\u60c5\u51b5<\/p>\n

Figure\u00a04. BP\u7eb3\u7c73\u75ab\u82d7\u53ef\u8bf1\u53d1\u7cfb\u7edf\u6027\u7684\u6297\u80bf\u7624\u514d\u75ab<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09B16-OVA\u8377\u7624\u5c0f\u9f20\u7684\u514d\u75ab\u6d41\u7a0b<\/p>\n

b\uff09\u4e0d\u540c\u5b9e\u9a8c\u7ec4\u7684\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u66f2\u7ebf<\/p>\n

c\uff09\u4e0d\u540c\u5b9e\u9a8c\u7ec4\u7684\u5c0f\u9f20\u751f\u5b58\u66f2\u7ebf<\/p>\n

d\uff09\u5c0f\u9f20\u813e\u810f\u5185CD8+<\/sup>\u00a0T\u7ec6\u80de\u4e2d\u7684CD69+<\/sup>\u00a0CD8+<\/sup>\u00a0T\u7ec6\u80de\u7684\u6bd4\u4f8b<\/p>\n

e-f\uff09\u6297\u539f\u518d\u523a\u6fc0\u540e\u5c0f\u9f20\u813e\u810f\u4e2dIFN-\u03b3+<\/sup>\u00a0CD8+<\/sup>\u00a0T\u7ec6\u80de\u53d8\u5316\u53ca\u5b9a\u91cf\u5206\u6790<\/p>\n

g-h\uff09\u6297\u539f\u518d\u523a\u6fc0\u540e\u5c0f\u9f20\u80bf\u7624\u4e2dIFN-\u03b3+<\/sup>\u00a0CD8+<\/sup>\u00a0T\u7ec6\u80de\u53d8\u5316\u53ca\u5b9a\u91cf\u5206\u6790<\/p>\n

i-k\uff09ELISA\u6d4b\u5b9a\u8377\u7624\u5c0f\u9f20\u8840\u6e05\u4e2d\u7ec6\u80de\u56e0\u5b50\u542b\u91cf\uff1ai\uff09IL-2\uff0cj\uff09TNF-\u03b1\uff0ck\uff09TGF-\u03b2<\/p>\n

Figure\u00a05. NIR\u4ecb\u5bfc\u7684\u6e29\u548c\u5149\u70ed\u4fc3\u8fdbBP\u7eb3\u7c73\u75ab\u82d7\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09\u7ea2\u5916\u6210\u50cf\u4eea\u6d4b\u5b9a\u4f53\u5916PBS\u6eb6\u6db2\u4e2dFKF-OVAp@BP\u7684\u5149\u70ed\u53d8\u5316<\/p>\n

b\uff09B16-OVA\u8377\u7624\u5c0f\u9f20\u7684\u5149\u70ed\u53ca\u8054\u5408\u7597\u6cd5\u6d41\u7a0b\u793a\u610f<\/p>\n

c\uff09\u4e0d\u540c\u5b9e\u9a8c\u7ec4\u7684\u6d3b\u4f53\u7ea2\u5916\u6210\u50cf<\/p>\n

d\uff09\u4e0d\u540c\u5b9e\u9a8c\u7ec4\u7684\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u66f2\u7ebf<\/p>\n

e\uff09\u4e0d\u540c\u5b9e\u9a8c\u7ec4\u7684\u5c0f\u9f20\u751f\u5b58\u66f2\u7ebf<\/p>\n

f\uff09\u514d\u75ab\u540e\u5c0f\u9f20\u80bf\u7624\u7ec4\u7ec7\u5207\u7247\u7684H&E\u67d3\u8272\u56fe<\/p>\n

g\uff09\u80bf\u7624\u6d78\u6da6APC\u4e2d\u6d3b\u5316\u5de8\u566c\u7ec6\u80de\uff08M\u03a6\uff09\u548c\u6d3b\u5316DC\u7684\u6bd4\u4f8b<\/p>\n

h\uff09\u80bf\u7624\u5185\u6548\u5e94\u6027CD8+<\/sup>\u00a0T\u7ec6\u80de\uff08Teff<\/sub>\uff09\u4e0e\u8c03\u8282\u6027CD4+<\/sup>\u00a0T\u7ec6\u80de\uff08Treg<\/sub>\uff09\u7684\u6bd4\u4f8b\u53d8\u5316<\/p>\n

i\uff09\u813e\u810f\u5185CD8+<\/sup>\u00a0T\u4e2d\u6548\u5e94\u8bb0\u5fc6\u578bT\u7ec6\u80de\uff08Tem<\/sub>\uff09\u548c\u4e2d\u592e\u8bb0\u5fc6\u578bT\u7ec6\u80de\uff08Tcm<\/sub>\uff09\u7684\u542b\u91cf<\/p>\n

j-k\uff09ELISPOT\u6d4b\u5b9a\u5149\u70ed\u53ca\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u540e\u5c0f\u9f20\u813e\u810f\u5185\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u53d8\u5316\u53ca\u5b9a\u91cf<\/p>\n

\u5c0f\u7ed3<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u7814\u7a76\u56e2\u961f\u5bf9BP\u7684\u591a\u79cd\u514d\u75ab\u589e\u6548\u6027\u8d28\u8fdb\u884c\u63a2\u7a76\uff1a1\uff09\u5229\u7528BP\u7684\u8868\u9762\u5316\u5b66\u7269\u7406\u6027\u8d28\u5b9e\u73b0\u6297\u539f\u7ec4\u5408\uff0c2\uff09\u63a2\u7a76BP\u672c\u8eab\u4f50\u5242\u6027\u8d28\uff0c\u5b9e\u73b0\u6781\u7b80\u75ab\u82d7\u8bbe\u8ba1\u4e0e\u6297\u80bf\u7624\u7597\u6cd5\u5e94\u7528\uff0c3\uff09\u6316\u6398\u5e76\u5229\u7528BP\u56fa\u6709\u7684\u5316\u5b66\u7269\u7406\u6027\u8d28\uff08\u5982\u5149\u70ed\u6027\u8d28\uff09\uff0c\u63a2\u7a76\u5176\u5bf9\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u7684\u6539\u5584\u548c\u6cbb\u7597\u8f85\u52a9\u3002\u7814\u7a76\u5de5\u4f5c\u5b9e\u73b0\u4e86\u4e00\u4f53\u5316\u3001\u591a\u529f\u80fd\u7684\u4f50\u5242\uff0c\u4e0d\u4ec5\u4fc3\u8fdb\u4e86\u4eba\u4eec\u5bf9BP\u7684\u4f50\u5242\u529f\u80fd\u7406\u89e3\uff0c\u540c\u65f6\u4e3a\u540e\u7eed\u5f00\u53d1\u6574\u5408\u578b\u3001\u591a\u529f\u80fd\u5316\u7684\u65b0\u578b\u7eb3\u7c73\u4f50\u5242\u6750\u6599\u63d0\u4f9b\u4e86\u91cd\u8981\u57fa\u7840\u548c\u5408\u7406\u65b9\u6848\u3002<\/p>\n

\u539f\u6587\u4fe1\u606f<\/b><\/strong>\uff1a<\/b><\/strong>Wen-Hao Li, Jun-Jun Wu, Lie Wu, Bo-Dou Zhang, Hong-Guo Hu, Lang Zhao, Zhi-Bin Li, Xue-Feng Yu*, Yan-Mei Li*. Black phosphorous nanosheet: A novel immune-potentiating nanoadjuvant for near-infrared-improved immunotherapy. Biomaterials<\/i><\/b><\/em><\/strong>\u00a02021, DOI:\u00a010.1016\/j.biomaterials.2021.120788<\/p>\n

\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1016\/j.biomaterials.2021.120788<\/p>\n

\u672c\u6587\u7531\u4f5c\u8005\u6295\u7a3f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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