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\u901a\u8fc7Web of Science\uff08SCI\uff09\u68c0\u7d22\u6c34\u51dd\u80f6\u7814\u7a76\u65b9\u5411\u7684\u53d1\u6587\u60c5\u51b5\u3002\u5982\u56fe1\u6240\u793a\uff0c\u5176\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u662f\u5316\u5b66\u548c\u6750\u6599\u79d1\u5b66\u9886\u57df\uff0c\u5176\u4e2d\u5316\u5b66\u9886\u57df\u5df2\u8d85\u8fc726000\u7bc7\u3002\u540c\u65f6\uff0c\u8fd8\u68c0\u7d22\u4e86\u6c34\u51dd\u80f6\u7684\u51fa\u7248\u5e74\u60c5\u51b5\u3002\u5982\u56fe2\u6240\u793a\uff0c\u57282017\u5e74\u662f8293\u7bc7\uff0c\u57282018-2020\u5e74\u90fd\u662f\u63a5\u8fd1\u6216\u5df2\u8d85\u8fc7\u6bcf\u5e7410000\u7bc7\u3002\u800c\u57282021\u5e74\u4e5f\u5df2\u663e\u793a\u53d1\u8868\u4e863000\u591a\u7bc7\uff0c\u4ee5\u6b64\u901f\u5ea6\uff0c2021\u5e74\u8d85\u8fc710000\u7bc7\u4e5f\u4e0d\u662f\u96be\u4e8b\uff01\u56e0\u6b64\uff0c\u672c\u6b21\u9009\u62e9\u4e86\u5927\u725b\u56e2\u961f\u8fd1\u671f\u5728\u4f18\u8d28\u671f\u520a\u4e0a\u53d1\u8868\u7684\u6709\u5173\u4e8e\u6c34\u51dd\u80f6\u7684\u6587\u7ae0\uff0c\u4f9b\u5927\u5bb6\u4e86\u89e3\u53ca\u5b66\u4e60!<\/p>\n
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1\u3001Nat. Nanotechnol.\uff1a<\/b><\/strong>\u7531\u56db\u9762\u4f53\u7c7b\u5355\u4f53\u7ec4\u6210\u7684\u9ad8\u5ea6\u5747\u8d28\u7684\u805a\u5408\u7269\uff0c\u7528\u4e8e\u9ad8\u5404\u5411\u540c\u6027\u81a8\u80c0\u663e\u5fae\u955c<\/b><\/strong><\/p>\n \u81a8\u80c0\u663e\u5fae\u955c\uff08ExM\uff09\u5728\u7269\u7406\u4e0a\u653e\u5927\u4e86\u751f\u7269\u6807\u672c\uff0c\u4ece\u800c\u53ef\u4ee5\u4f7f\u7528\u5e38\u89c4\u663e\u5fae\u955c\u8fdb\u884c\u7eb3\u7c73\u7ea7\u5206\u8fa8\u7387\u7684\u6210\u50cf\u3002\u76ee\u524d\u7684ExM\u65b9\u6cd5\u662f\u901a\u8fc7\u81ea\u7531\u57fa\u94fe\u751f\u957f\u805a\u5408\u805a\u4e19\u70ef\u9178\u916f\u6c34\u51dd\u80f6\u6e17\u900f\u6837\u54c1\uff0c\u5176\u7f51\u7edc\u7ed3\u6784\u9650\u5236\u4e86\u5c40\u90e8\u81a8\u80c0\u7684\u5411\u540c\u6027\u4ee5\u53ca\u5728\u7eb3\u7c73\u5c3a\u5ea6\u4e0a\u4fdd\u6301\u5f62\u6001\u548c\u5f62\u72b6\u3002\u57fa\u4e8e\u6b64\uff0c\u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff08MIT\uff09<\/b><\/strong>Edward S. Boyden<\/b><\/strong>\u7b49\u4eba<\/b><\/strong>\u62a5\u9053\u4e86\u4e00\u79cdExM\uff0c\u5176\u4f7f\u7528\u7684\u6c34\u51dd\u80f6\u5177\u6709\u66f4\u5747\u5300\u7684\u7f51\u7edc\u7ed3\u6784\uff0c\u901a\u8fc7\u56db\u9762\u4f53\u5355\u4f53\u7684\u975e\u81ea\u7531\u57fa\u672b\u7aef\u8fde\u63a5\u7ec4\u88c5\u800c\u6210\u3002\u4e0d\u540c\u4e8e\u65e9\u671f\u5f62\u5f0f\u7684ExM\uff0c\u8fd9\u79cd\u56db\u51dd\u80f6\u5d4c\u5165\u5f0f\u6807\u672c\u53ef\u4ee5\u53cd\u590d\u81a8\u80c0\u4ee5\u83b7\u5f97\u66f4\u5927\u7684\u7269\u7406\u653e\u5927\u500d\u6570\u3002\u5728\u7ebf\u6027\u5c3a\u5bf8\u4e0a\uff0c\u53cd\u590d\u56db\u51dd\u80f6\u6cd5\u5c06\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd21\u578b\uff08HSV-1\uff09\u75c5\u6bd2\u7c92\u5b50\u6269\u589e\u7ea610\u500d\uff0c\u5bfc\u81f4\u75c5\u6bd2\u5305\u819c\u5c42\u5b9a\u4f4d\u7684\u4e2d\u4f4d\u7a7a\u95f4\u8bef\u5dee\u4e3a9.2 nm\uff0c\u800c\u4e0d\u662f\u65e9\u671fExM\u768414.3 nm\u3002\u6b64\u5916\uff0c\u4ee5\u56db\u51dd\u80f6\u4e3a\u57fa\u7840\u7684\u81a8\u80c0\u66f4\u597d\u5730\u4fdd\u6301\u75c5\u6bd2\u7c92\u5b50\u7684\u7403\u5f62\u5f62\u72b6\u3002\u56e0\u6b64\uff0c\u56db\u51dd\u80f6\u53ef\u4ee5\u5728\u51cf\u5c11\u7a7a\u95f4\u8bef\u5dee\u548c\u6539\u5584\u5c40\u90e8\u5404\u5411\u540c\u6027\u7684\u60c5\u51b5\u4e0b\u652f\u6301ExM\uff0c\u4e3a\u5355\u4e00\u751f\u7269\u5206\u5b50\u7cbe\u786e\u5ea6\u7684ExM\u6307\u660e\u4e86\u65b9\u5411\u3002<\/p>\n \u6587\u7ae0\u4fe1\u606f\uff1a<\/p>\n A highly homogeneous polymer composed of\u00a0tetrahedron-like monomers for high-isotropy\u00a0expansion microscopy. Nat. Nanotechnol.,<\/i><\/em>\u00a02021<\/b><\/strong>, DOI: 10.1038\/s41565-021-00875-7.<\/p>\n https:\/\/doi.org\/10.1038\/s41565-021-00875-7<\/p>\n 2\u3001Nat. Biomed. Eng.\uff1a<\/b><\/strong>\u5229\u7528\u53cc\u7f51\u7edc\u6c34\u51dd\u80f6\u5feb\u901f\u91cd\u7f16\u7a0b\u80bf\u7624\u7ec6\u80de\u6210\u4e3a\u764c\u75c7\u5e72\u7ec6\u80de<\/b><\/strong><\/p>\n \u764c\u75c7\u590d\u53d1\u53ef\u80fd\u662f\u7531\u4e8e\u7f55\u89c1\u7684\u5faa\u73af\u764c\u5e72\u7ec6\u80de\uff08CSCs\uff09\u5bf9\u5316\u7597\u548c\u653e\u5c04\u6cbb\u7597\u4ea7\u751f\u8010\u836f\u6027\u3002\u57fa\u4e8e\u6b64\uff0c\u65e5\u672c\u5317\u6d77\u9053\u5927\u5b66<\/b><\/strong>Shinya Tanaka<\/b><\/strong>\u548c\u9f9a\u5251\u840d\u6559\u6388\u7b49\u4eba<\/b><\/strong>\u62a5\u9053\u4e86\u4e00\u79cd\u53cc\u7f51\u7edc\u6c34\u51dd\u80f6\u53ef\u4ee5\u5feb\u901f\u5730\u5c06\u5206\u5316\u7684\u764c\u7ec6\u80de\u91cd\u7f16\u7a0b\u4e3aCSCs\u3002\u8868\u8fbe\u9ad8\u6c34\u5e73\u5e72\u7ec6\u80de\u57fa\u56e0Sox2\u3001Oct3\/4\u548cNanog\u7684\u7403\u4f53\u5728\u63a5\u79cd6\u79cd\u4eba\u7c7b\u80bf\u7624\u7ec6\u80de\u7cfb\u7684\u7ec6\u80de\u6216\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u5207\u9664\u7684\u8111\u764c\u7ec6\u80de\u540e24 h\u5185\u5f62\u6210\u3002\u5728\u53cc\u7f51\u7edc\u6c34\u51dd\u80f6\u4e0a\u57f9\u517b\u7684\u4eba\u8111\u764c\u7ec6\u80de\u548c\u5728\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u4e2d\u7684\u9885\u5185\u6ce8\u5c04\u5bfc\u81f4\u6bd4\u5728\u5355\u7f51\u7edc\u51dd\u80f6\u4e0a\u57f9\u517b\u7684\u8111\u764c\u7ec6\u80de\u5177\u6709\u66f4\u9ad8\u7684\u81f4\u7624\u6027\u3002\u4f5c\u8005\u8fd8\u53d1\u73b0\u53cc\u7f51\u51dd\u80f6\u8bf1\u5bfc\u916a\u6c28\u9178\u6fc0\u9176\u7684\u78f7\u9178\u5316\uff0c\u51dd\u80f6\u8bf1\u5bfc\u7684\u539f\u53d1\u6027\u8111\u764c\u7ec6\u80de\u4e2d\u7684CSCs\u88ab\u8840\u5c0f\u677f\u6e90\u6027\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u7684\u6291\u5236\u5242\u6e05\u9664\uff0c\u9499\u901a\u9053\u53d7\u4f53\u548c\u9aa8\u6865\u86cb\u767d\u5728\u51dd\u80f6\u4ecb\u5bfc\u7684\u80bf\u7624\u8bf1\u5bfc\u4e2d\u8d77\u7740\u91cd\u8981\u7684\u8c03\u8282\u4f5c\u7528\u8111\u764c\u7ec6\u80de\u7684\u5e72\u7ec6\u80de\u3002<\/p>\n \u6587\u7ae0\u4fe1\u606f\uff1a<\/p>\n Rapid reprogramming of tumour cells into cancer\u00a0stem cells on double-network hydrogels. Nat. Biomed. Eng.,<\/i><\/em>\u00a02021<\/b><\/strong>, DOI: 10.1038\/s41551-021-00692-2.<\/p>\n https:\/\/doi.org\/10.1038\/s41551-021-00692-2.<\/p>\n 3\u3001Nat. Chem. Bio.\uff1a<\/b><\/strong>\u6d77\u85fb\u9178\/\u805a\u4e19\u70ef\u9170\u80fa\u57fa\u6838-\u58f3\u6c34\u51dd\u80f6\u7528\u4e8e\u7ec6\u83cc\u5fae\u751f\u7269\u7684\u5f3a\u529b\u5c01\u88c5<\/b><\/strong><\/p>\n \u8fd1\u5e74\u6765\uff0c\u8f6c\u57fa\u56e0\u5fae\u751f\u7269\uff08GMMs\uff09\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u73af\u5883\u4f20\u611f\u548c\u54cd\u5e94\u6027\u5de5\u7a0b\u751f\u7269\u6750\u6599\u7b49\u9886\u57df\u3002\u7136\u800c\uff0c\u63a7\u5236GMMs\u4ee5\u9632\u6b62\u73af\u5883\u9003\u9038\u5e76\u6ee1\u8db3\u76d1\u7ba1\u8981\u6c42\u662f\u5b9e\u9645\u5e94\u7528\u4e2d\u7684\u4e00\u4e2a\u74f6\u9888\u3002\u867d\u7136\u5f53\u524d\u7684\u751f\u5316\u7b56\u7565\u9650\u5236\u4e86GMMs\u5728\u73af\u5883\u4e2d\u4e0d\u5fc5\u8981\u7684\u589e\u957f\uff0c\u4f46\u662f\u9700\u8981\u90e8\u7f72\u7269\u7406\u904f\u5236\u6280\u672f\u6765\u5b9e\u73b0\u5197\u4f59\u3001\u591a\u5c42\u548c\u7a33\u5b9a\u7684\u904f\u5236\u3002\u57fa\u4e8e\u6b64\uff0c\u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff08MIT\uff09\u8d75\u9009\u8d3a\u6559\u6388\u548c\u5362\u51a0\u8fbe\u6559\u6388\u7b49\u4eba<\/b><\/strong>\u62a5\u9053\u4e86\u4e00\u79cd\u57fa\u4e8e\u6c34\u51dd\u80f6\u7684\u5c01\u88c5\u7cfb\u7edf\u3002\u5176\u5305\u542b\u4e86\u4e00\u4e2a\u751f\u7269\u76f8\u5bb9\u6027\u7684\u591a\u5c42\u786c\u58f3\u548c\u4e00\u4e2a\u57fa\u4e8e\u6d77\u85fb\u9178\u94a0\u7684\u6838\uff0c\u7ed3\u5408\u4e86\u5f39\u6027\u805a\u5408\u7269\u7f51\u7edc\uff08\u805a\u4e19\u70ef\u9170\u80fa\uff09\u548c\u80fd\u91cf\u8017\u6563\u7f51\u7edc\uff08\u85fb\u9178\u76d0\uff0c\u901a\u8fc7\u805a\u5408\u7269\u4e4b\u95f4\u79bb\u5b50\u4ea4\u8054\u7684\u89e3\u94fe\uff09\uff0c\u800c\u8fd9\u79cd\u5916\u58f3\u6750\u6599\u975e\u5e38\u575a\u97e7\uff0c\u4e0d\u6613\u65ad\u88c2\uff0c\u80fd\u4fdd\u6301\u5bf9\u5c0f\u5206\u5b50\u7684\u6e17\u900f\u6027\u3002\u8fd9\u79cd\u53ef\u90e8\u7f72\u7684\u7269\u7406\u904f\u5236\u7b56\u7565\uff08DEPCOS\uff09\u4f7fGMM\u65e0\u6cd5\u9003\u9038\uff0c\u7ec6\u83cc\u53ef\u4ee5\u53d7\u5230\u4fdd\u62a4\uff0c\u514d\u53d7\u73af\u5883\u6c61\u67d3\uff0c\u5305\u62ec\u6297\u751f\u7d20\u548c\u4f4epH\u503c\uff0c\u53ef\u63a7\u7684\u5bff\u547d\u548c\u6613\u4e8e\u68c0\u7d22\u7684\u57fa\u56e0\u7ec4\u7f16\u7801\u7ec6\u83cc\u3002\u4e3a\u4e86\u7a81\u51faDEPCOS\u7684\u591a\u529f\u80fd\u6027\uff0c\u4f5c\u8005\u8bc1\u660e\u4e86\u7262\u56fa\u5305\u88f9\u7684\u7ec6\u80de\u53ef\u4ee5\u6267\u884c\u6709\u7528\u7684\u529f\u80fd\uff0c\u5305\u62ec\u4e0e\u5176\u4ed6\u5305\u88f9\u7684\u7ec6\u83cc\u8fdb\u884c\u7ec6\u80de-\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u548c\u68c0\u6d4b\u67e5\u5c14\u65af\u6cb3\u6c34\u6837\u4e2d\u7684\u91cd\u91d1\u5c5e\u3002<\/p>\n \u6587\u7ae0\u4fe1\u606f\uff1a<\/p>\n<\/p>\n
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