{"id":220312,"date":"2021-04-11T06:30:01","date_gmt":"2021-04-10T22:30:01","guid":{"rendered":"\/\/m.iemloyee.com\/?p=220312"},"modified":"2021-04-10T21:30:11","modified_gmt":"2021-04-10T13:30:11","slug":"%e6%ad%a6%e6%b1%89%e5%a4%a7%e5%ad%a6%e5%bc%a0%e5%85%88%e6%ad%a3adv-funct-mater-%e7%bb%86%e8%8f%8c%e8%af%b1%e5%af%bc%e7%9a%84%e8%82%bf%e7%98%a4%e7%89%b9%e5%bc%82%e6%80%a7%e5%87%9d%e8%a1%80%e5%90%b8","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=220312","title":{"rendered":"\u6b66\u6c49\u5927\u5b66\u5f20\u5148\u6b63Adv. Funct. Mater.: \u7ec6\u83cc\u8bf1\u5bfc\u7684\u80bf\u7624\u7279\u5f02\u6027\u51dd\u8840\u5438\u5f15\u6297\u4f53\u5de5\u7a0b\u8840\u5c0f\u677f\u7528\u4e8e\u68c0\u67e5\u70b9\u6291\u5236\u5242\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"<p>\u3010<strong><b>\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n<p>\u901a\u5e38\uff0c\u65e0\u5e8f\u7684\u80bf\u7624\u5fae\u73af\u5883\u4f34\u968f\u7740\u7f3a\u6c27\uff0c\u8fc7\u8425\u517b\u5316\u548c\u514d\u75ab\u8d66\u514d\uff0c\u8fd9\u53ef\u4ee5\u4e3a\u7ec6\u83cc\uff0c\u5c24\u5176\u662f\u517c\u6027\u538c\u6c27\u83cc\u63d0\u4f9b\u751f\u5b58\u7a7a\u95f4\u3002\u56e0\u6b64\uff0c\u7ec6\u83cc\u975e\u5e38\u9002\u5408\u7528\u4e8e\u51c6\u786e\u533a\u5206\u80bf\u7624\u7ec4\u7ec7\u548c\u6b63\u5e38\u7ec4\u7ec7\u3002\u57fa\u4e8e\u6b64\uff0c\u5404\u79cd\u7ec6\u83cc\u88ab\u521b\u9020\u6027\u5730\u7528\u4f5c\u6297\u80bf\u7624\u5e73\u53f0\uff0c\u5df2\u88ab\u57fa\u56e0\u6539\u9020\u4e3a\u86cb\u767d\u8d28\u836f\u7269\u5de5\u5382\uff0c\u6216\u88ab\u91cd\u5851\u4e3a\u7528\u4e8e\u96be\u6cbb\u6027\u80bf\u7624\u6cbb\u7597\u7684\u514d\u75ab\u7597\u6cd5\u75ab\u82d7\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u6211\u4eec\u53d1\u73b0\u4f4e\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83ccTOP10\u9664\u5177\u6709\u9776\u5411\u80bf\u7624\u7684\u80fd\u529b\u5916\uff0c\u8fd8\u53ef\u4ee5\u5728\u80bf\u7624\u533a\u57df\u800c\u975e\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u5f15\u8d77\u5feb\u901f\u800c\u5f3a\u70c8\u7684\u8840\u6db2\u51dd\u7ed3\u3002\u5728\u9759\u8109\u6ce8\u5c04\u8be5\u7ec6\u83cc\u540e\uff0c\u53ef\u89c2\u5bdf\u5230\u5728\u80bf\u7624\u5185\u5c24\u5176\u662f\u672a\u6210\u719f\u7684\u8109\u7ba1\u7cfb\u7edf\u4e2d\u53d1\u751f\u660e\u663e\u7684\u51fa\u8840\u3002\u6211\u4eec\u63a8\u6d4b\u8fd9\u79cd\u7ec6\u83cc\u8bf1\u5bfc\u7684\u51dd\u7ed3\uff08BIC\uff09\u662f\u7531\u7ec6\u83cc\u5f15\u8d77\u7684\u5c40\u90e8\u708e\u75c7\u89e6\u53d1\uff0c\u5e76\u8fdb\u4e00\u6b65\u9020\u6210\u7ea4\u7ef4\u86cb\u767d\u6c89\u79ef\u548c\u8840\u7ba1\u7834\u574f\u3002\u540c\u65f6\uff0c\u8fd9\u4e00\u80bf\u7624\u4e2d\u7531\u708e\u75c7\u4ecb\u5bfc\u7684\u5f02\u5e38\u51fa\u8840\u548c\u8840\u6db2\u51dd\u56fa\u53ef\u89e6\u53d1\u514d\u75ab\u7ec6\u80de\u7684\u663e\u7740\u52df\u96c6\u548c\u6d78\u6da6\uff0c\u5305\u62ecT\u7ec6\u80de\uff0c\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7b49\u5728\u5185\u7684\u5929\u7136\u514d\u75ab\u7ec6\u80de\u662f\u62b5\u6297\u80bf\u7624\u7ec6\u80de\u751f\u957f\u7684\u6740\u624b\u3002\u7136\u800c\uff0c\u80bf\u7624\u7ec6\u80de\u4e2d\u5e7f\u6cdb\u5b58\u5728\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u5305\u62ec\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f531\uff08PD-L1\uff09\uff0c\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u6297\u539f4\uff08CTLA-4\uff09\u548cCD47\u7b49\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u963b\u788d\u4e86\u514d\u75ab\u7ec6\u80de\u5bf9\u5176\u8bc6\u522b\u4f5c\u7528\uff0c\u964d\u4f4e\u4e86\u5176\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\u3002\u5f15\u5165\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53ef\u4ee5\u5f88\u597d\u5730\u7f13\u89e3\u80bf\u7624\u4e2d\u514d\u75ab\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u3002\u4f46\u662f\u4f20\u7edf\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e0d\u662f\u80bf\u7624\u7279\u5f02\u6027\u7684\uff0c\u5e76\u4e14\u53ef\u80fd\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u8bf1\u5bfc\u5168\u8eab\u6027\u514d\u75ab\u6fc0\u6d3b\u3002\u800c\u7ec6\u83cc\u80fd\u591f\u7cbe\u51c6\u5730\u5728\u80bf\u7624\u4e2d\u5f15\u8d77\u8840\u6db2\u51dd\u7ed3\uff0c\u7a81\u51fa\u4e86\u80bf\u7624\u7684\u7279\u5f81\uff0c\u5e76\u56e0\u6b64\u800c\u5438\u5f15\u5927\u91cf\u7684\u8840\u5c0f\u677f\u8fdb\u5165\u80bf\u7624\u5fae\u73af\u5883\u3002\u57fa\u4e8e\u6b64\uff0c\u8840\u5c0f\u677f\u975e\u5e38\u9002\u5408\u88ab\u6297\u4f53\u5de5\u7a0b\u5316\uff0c\u4f5c\u4e3a\u5728\u4eba\u5de5\u8bf1\u5bfc\u7684BIC\u540e\u9012\u9001\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u5929\u7136\u8f7d\u4f53\u751f\u7269\u6750\u6599\u3002<\/p>\n<p>\u3010<strong><b>\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n<p>\u7531\u4e8e\u7ec6\u83cc\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u7684\u7279\u5f02\u6027\u9776\u5411\u80fd\u529b\uff0c\u7ec6\u83cc\u53ef\u4ee5\u4f5c\u4e3a\u6709\u5e0c\u671b\u7684\u6297\u80bf\u7624\u5e73\u53f0\u3002<strong><b>\u6b66\u6c49\u5927\u5b66\u5f20\u5148\u6b63\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/b><\/strong>\u53d1\u73b0\u9759\u8109\u5185\u65bd\u7528\u5927\u80a0\u6746\u83ccTOP10\u53ef\u5728\u80bf\u7624\u7ec4\u7ec7\u800c\u4e0d\u662f\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u5f15\u8d77\u5feb\u901f\u800c\u5f3a\u70c8\u7684\u8840\u6db2\u51dd\u7ed3\u3002\u5df2\u8bc1\u660e\u5927\u80a0\u6746\u83ccTOP10\u53ef\u4ee5\u5145\u5f53\u51dd\u8840\u7ea7\u8054\u7684\u6fc0\u6d3b\u5242\uff0c\u4ee5\u89e6\u53d1\u80bf\u7624\u5185\u7279\u5f02\u6027\u7684\u8840\u6db2\u51dd\u56fa\u548c\u708e\u75c7\uff0c\u5e76\u5728\u80bf\u7624\u4e2d\u52df\u96c6\u5927\u91cf\u5de8\u566c\u7ec6\u80de\u3002\u53e6\u5916\uff0c\u52df\u96c6\u7684\u5de8\u566c\u7ec6\u80de\u88ab\u8bc1\u5b9e\u80fd\u591f\u88ab\u7ec6\u83cc\u58c1\u4e2d\u7684\u8102\u591a\u7cd6\u7531\u4fc3\u80bf\u7624\u7684M2\u8868\u578b\u6781\u5316\u6210\u5177\u6709\u6297\u80bf\u7624\u529f\u80fd\u7684M1\u8868\u578b\u3002\u57fa\u4e8e\u4e0a\u8ff0\u53d1\u73b0\uff0c\u8fdb\u4e00\u6b65\u5236\u5907\u4e86\u7531CD47\u6297\u4f53\u4fee\u9970\u7684\u51dd\u8840\u8d8b\u5411\u6027\u8840\u5c0f\u677f\uff0c\u5176\u5177\u6709\u7ec6\u83cc\u6cbb\u7597\u7684\u80bf\u7624\u7684\u8d8b\u5411\u6027\u4ece\u800c\u8fd0\u9001CD47\u6297\u4f53\u7cbe\u51c6\u5230\u8fbe\u80bf\u7624\u533a\u57df\u3002\u5b9e\u9a8c\u7ed3\u679c\u8bc1\u660e\uff0c\u901a\u8fc7\u5de5\u7a0b\u5316\u8840\u5c0f\u677fCD47\u6297\u4f53\u7684\u51c6\u786e\u9012\u9001\uff0c\u963b\u6b62\u4e86\u80bf\u7624\u7ec6\u80de\u53d1\u51fa\u7684\u201c\u4e0d\u8981\u5403\u6211\u201d\u4fe1\u53f7\uff0c\u4ece\u800c\u4fc3\u8fdb\u4e86\u80bf\u7624\u7ec6\u80de\u6781\u5316M1\u578b\u8868\u578b\u5de8\u566c\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\u3002\u80bf\u7624\u4e2d\u8fd9\u79cd\u7531\u7ec6\u83cc\u5f15\u53d1\u7684\u5c40\u90e8\u51dd\u8840\u4e0e\u5de5\u7a0b\u5316\u8840\u5c0f\u677f\u8054\u7528\uff0c\u53ef\u80fd\u4e3a\u51c6\u786e\u9012\u9001\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u548c\u4fc3\u8fdb\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u627e\u5230\u66f4\u591a\u53ef\u80fd\u7684\u53d1\u5c55\u65b9\u5411\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201c<\/strong><strong>Antibody Engineered Platelets Attracted by Bacteria-Induced Tumor-Specific Blood Coagulation for Checkpoint Inhibitor Immunotherapy<\/strong><strong>\u201d<\/strong>\u53d1\u8868\u5728<strong><b>Adv. Funct. Mater.<\/b><\/strong><strong>\u4e0a<\/strong>\u3002<\/p>\n<p><strong><b>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n<p><strong><b>Scheme 1.\u672c\u7814\u7a76\u4e2d\u7684\u6cbb\u7597\u8fc7\u7a0b\u793a\u610f\u56fe<\/b><\/strong><\/p>\n<p><strong><b><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-220313\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rs1.jpg\" alt=\"\" width=\"600\" height=\"383\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rs1.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rs1-300x192.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\u00a0<\/b><\/strong><\/p>\n<p><strong><b>Figure 1.\u5927\u80a0\u6746\u83ccTOP10\u80fd\u591f\u7279\u5f02\u6027\u5f15\u53d1\u80bf\u7624\u533a\u57df\u7684\u5c40\u90e8\u51dd\u8840<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-220314\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf1.jpg\" alt=\"\" width=\"600\" height=\"598\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf1.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf1-150x150.jpg 150w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf1-300x300.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a\uff09\u5927\u80a0\u6746\u83ccTOP10\u5728\u80bf\u7624\u533a\u57df\u5f15\u53d1\u7279\u5f02\u6027\u51dd\u8840\u793a\u610f\u56fe\u00a0b\uff09\u7ec6\u83cc\u3001\u706d\u6d3b\u7ec6\u83cc\u548c\u9634\u6027\u5bf9\u7167\u7ec4\u5904\u7406\u540e\u7684\u80bf\u7624\u7ec4\u7ec7\u7684H\uff06E\u67d3\u8272\uff0c\u9769\u5170\u6c0f\u67d3\u8272\u548cMasson\u67d3\u8272\u5207\u7247\u00a0c\uff09\u80bf\u7624\u533a\u57df\u8840\u7ba1\u7684\u5149\u58f0\u6210\u50cf\u00a0d\uff09\u7ec6\u83cc\u548c\u706d\u6d3b\u7ec6\u83cc\u5904\u7406\u540e\u7684CT26\u80bf\u7624\u4e2d\u538c\u6c27\u8840\u7ea2\u86cb\u767d\u548c\u597d\u6c27\u8840\u7ea2\u86cb\u767d\u7684\u4ee3\u8868\u6027\u4e8c\u7ef4\u5149\u58f0\u6210\u50cf\u00a0e\uff09\u7ec6\u83cc\u548c\u706d\u6d3b\u7ec6\u83cc\u5904\u7406\u540e\u7684CT26\u80bf\u7624\u4e2d\u7684\u6c27\u5408\u8840\u7ea2\u86cb\u767d\u9971\u548c\u5ea6\u5b9a\u91cf f\uff09\u7ec6\u83cc\u3001\u706d\u6d3b\u7ec6\u83cc\u548c\u9634\u6027\u5bf9\u7167\u7ec4\u4e2dCT26\u80bf\u7624\u7684\u51dd\u8840\u56e0\u5b50VII\u6d53\u5ea6 g\uff09KEGG\u5bcc\u96c6\u5206\u6790\u9274\u5b9a\u51fa\u7684\u53c2\u4e0e\u8840\u6db2\u51dd\u56fa\u548c\u708e\u75c7\u529f\u80fd\u7684\u5dee\u5f02\u4ee3\u8c22\u9014\u5f84 h\uff09\u4e0e\u8840\u6db2\u51dd\u56fa\u548c\u708e\u75c7\u529f\u80fd\u6709\u5173\u7684\u4e0d\u540c\u4ee3\u8c22\u7269\u7684\u70ed\u56fe i\uff09\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7ec6\u83cc\u5904\u7406\u540e\u7684CT26\u80bf\u7624\u4e2dTNF-\u03b1\u7684\u6d53\u5ea6 j\uff09\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7ec6\u83cc\u5904\u7406\u540e\u7684CT26\u80bf\u7624\u4e2dIFN-\u03b3\u7684\u6d53\u5ea6 k\uff09\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7ec6\u83cc\u5904\u7406\u540e\u7684CT26\u80bf\u7624\u4e2dIL-1\u03b2\u7684\u6d53\u5ea6 l\uff09\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7ec6\u83cc\u5904\u7406\u540e\u7684CT26\u80bf\u7624\u4e2dIL-6\u7684\u6d53\u5ea6 m\uff09\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7ec6\u83cc\u5904\u7406\u540e\u7684CT26\u80bf\u7624\u4e2dIL-12P40\u7684\u6d53\u5ea6<\/p>\n<p><strong><b>Figure 2.\u5927\u80a0\u6746\u83ccTOP10\u5728\u80bf\u7624\u5185\u5b9e\u73b0\u5de8\u566c\u7ec6\u80de\u7684\u52df\u96c6\u548c\u6781\u5316<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-220315\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf2.jpg\" alt=\"\" width=\"600\" height=\"461\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf2.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf2-300x231.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a\uff09\u7ec6\u83cc\u6cbb\u7597\u7ec4\u548c\u9634\u6027\u5bf9\u7167\u7ec4\u4e2d\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de\uff0cDC\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7684\u4ee3\u8868\u6027\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\u548c\u76f8\u5bf9\u5b9a\u91cf b\uff09\u7ec6\u83cc\u3001\u706d\u6d3b\u7ec6\u83cc\u548c\u5bf9\u7167\u7ec4\u7684CT26\u80bf\u7624\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272 c\uff09\u7528\u7ec6\u83cc\u3001\u706d\u6d3b\u7ec6\u83cc\u548c\u751f\u7406\u76d0\u6c34\u5206\u522b\u5904\u7406\u7684CT26\u80bf\u7624\u4e2dM1\u5de8\u566c\u7ec6\u80de\u548cM2\u5de8\u566c\u7ec6\u80de\u7684\u4ee3\u8868\u6027\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790 d\uff09\u4e0d\u540c\u5904\u7406\u5bf9\u5de8\u566c\u7ec6\u80de\u6781\u5316\u7684\u4ee3\u8868\u6027\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790<\/p>\n<p><strong><b>Figure 3. CD47\u6297\u4f53\u4fee\u9970\u7684\u5de5\u7a0b\u5316\u8840\u5c0f\u677f\u7684\u5236\u5907<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-220316\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf3.jpg\" alt=\"\" width=\"600\" height=\"504\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf3.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf3-300x252.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a\uff09\u901a\u8fc7\u8367\u5149\u539f\u4f4d\u6742\u4ea4\u6280\u672f\u6807\u8bb0\u7684\u5927\u80a0\u6746\u83ccTOP10\u5728\u809d\uff0c\u80be\u548cCT26\u80bf\u7624\u4e2d\u7684\u8367\u5149\u5206\u5e03\u3002b\uff09\u7ec6\u83cc\u5904\u7406\u7ec4\u548c\u9634\u6027\u5bf9\u7167\u7ec4\u5c0f\u9f20\u7684\u809d\uff0c\u80be\u548cCT26\u80bf\u7624\u7684\u9769\u5170\u6c0f\u67d3\u8272 c\uff09\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u6ce8\u5c04DIR\u6807\u8bb0\u7684\u7ec6\u83cc\u540e\u5bf9\u643a\u5e26CT26\u80bf\u7624\u7684\u5c0f\u9f20\u7684\u4f53\u5185\u8367\u5149\u6210\u50cf d\uff09\u6ce8\u5c04DIR\u6807\u8bb0\u7684\u7ec6\u83cc\u00a048 h\u540e\u4e3b\u8981\u5668\u5b98\u548c\u80bf\u7624\u7684\u79bb\u4f53\u8367\u5149\u6210\u50cf e\uff09\u6ce8\u5c04\u7ec6\u83cc\u00a048\u5c0f\u65f6\u540e\uff0c\u4e0d\u540c\u5668\u5b98\u4e2d\u7ec6\u83cc\u83cc\u843d\u7684\u5e73\u677f\u6d82\u5e03\u8ba1\u6570\u00a0f\uff09\u7ec6\u83cc\u5728\u80bf\u7624\u4e2d\u5f15\u8d77\u51dd\u8840\u7684\u53ef\u80fd\u673a\u5236 g\uff09P@aCD47\u7684\u5408\u6210\u65b9\u6cd5\u548c\u793a\u610f\u56fe h\uff09\u672a\u6d3b\u5316\uff08+\u524d\u5217\u817a\u7d20E1\uff09\u548c\u6d3b\u5316\uff08-\u524d\u5217\u817a\u7d20E1\uff09\u8840\u5c0f\u677f\u7684\u751f\u7269\u626b\u63cf\u7535\u5b50\u663e\u5fae\u955c\u56fe\u50cf i\uff09\u88c5\u8f7d\u6709CD47\u6297\u4f53\u7684\u8840\u5c0f\u677f\u8868\u9762\u5171\u805a\u7126\u663e\u5fae\u955c\u56fe\u50cf j\uff09\u8840\u5c0f\u677f\u8868\u9762\u6297\u4f53\u88c5\u8f7d\u60c5\u51b5\u7684\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790 k\uff09\u5728\u6ce8\u5c04\u7ec6\u83cc\u540e\u4e0d\u540c\u65f6\u95f4\u95f4\u9694\uff0c\u7ee7\u7eed\u6ce8\u5c04Cy5.5\u6807\u8bb0\u7684\u5de5\u7a0b\u5316\u8840\u5c0f\u677f\uff0c\u5728CT26\u8377\u7624\u5c0f\u9f20\u4e2d\u5bf9\u8840\u5c0f\u677f\u8fdb\u884c\u4f53\u5185\u8367\u5149\u6210\u50cf\uff0c\u8bc4\u4f30\u5176\u9776\u5411\u51dd\u8840\u90e8\u4f4d\u60c5\u51b5\u3002<\/p>\n<p><strong><b>Figure 4.\u5728\u5f02\u79cd\u79fb\u690dCT26\u8377\u7624\u5c0f\u9f20\u4e2d\u7684\u6297\u80bf\u7624\u4f5c\u7528<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-220317\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf4.jpg\" alt=\"\" width=\"600\" height=\"551\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf4.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf4-300x276.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a\uff09\u6cbb\u7597CT26\u5f02\u79cd\u79fb\u690d\u8377\u7624\u5c0f\u9f20\u7684\u7b80\u8981\u65f6\u95f4\u8868 b\uff09\u4e0d\u540c\u6cbb\u7597\u540e\u7684\u80bf\u7624\u4f53\u79ef c\uff09\u4e0d\u540c\u6cbb\u7597\u540e\u6bcf\u53ea\u5c0f\u9f20\u7684\u4e2a\u4f53\u80bf\u7624\u751f\u957f\u52a8\u529b\u5b66 d\uff09\u4e0d\u540c\u6cbb\u7597\u540e\u6240\u6536\u83b7\u80bf\u7624\u7684\u4ee3\u8868\u6027\u7167\u7247 e\uff09\u4e0d\u540c\u5904\u7406\u540e\u7684\u5c0f\u9f20\u80bf\u7624\u7684\u4f53\u5185\u751f\u7269\u53d1\u5149\u6210\u50cf f\uff09\u4e0d\u540c\u5904\u7406\u540e\u5c0f\u9f20\u7684\u8840\u751f\u5316\u4e0e\u8840\u5e38\u89c4\u68c0\u67e5\u6307\u6807 g\uff09\u4e0d\u540c\u5904\u7406\u540e\u7684\u5c0f\u9f20\u8840\u6d46CRP\u6d53\u5ea6 h\uff09\u4e0d\u540c\u5904\u7406\u540e\u7684\u5c0f\u9f20\u7684\u8840\u6d46PCT\u7684\u6d53\u5ea6 i\uff09\u4e0d\u540c\u6cbb\u7597\u80bf\u7624\u4e2dIFN-\u03b3\u7684\u6d53\u5ea6 j\uff09\u4e0d\u540c\u6cbb\u7597\u80bf\u7624\u4e2dIL-6\u7684\u6d53\u5ea6 k\uff09\u4e0d\u540c\u6cbb\u7597\u80bf\u7624\u4e2dIL-12P40\u7684\u6d53\u5ea6 l\uff09\u4ee3\u8868\u6027\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u548c\u4e0d\u540c\u6cbb\u7597\u65b9\u6cd5\u7684M1\u5de8\u566c\u7ec6\u80de\u548cM2\u5de8\u566c\u7ec6\u80de\u7684\u5b9a\u91cf\u7ed3\u679c m\uff09\u4e0d\u540c\u6cbb\u7597\u540e\u80bf\u7624\u7ec4\u7ec7\u7684\u514d\u75ab\u8367\u5149\u67d3\u8272\uff08CD206\uff09<\/p>\n<p><strong><b>Figure 5.\u5728\u8868\u8fbe\u8367\u5149\u7d20\u9176\u7684\u539f\u4f4dCT26\u80bf\u7624\u5c0f\u9f20\u4e2d\u7684\u6297\u80bf\u7624\u4f5c\u7528<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-220318\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf5.jpg\" alt=\"\" width=\"600\" height=\"602\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf5.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf5-150x150.jpg 150w, \/\/m.iemloyee.com\/wp-content\/uploads\/2021\/04\/rf5-300x300.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a\uff09\u643a\u5e26\u5c0f\u9f20\u7684\u539f\u4f4dCT26\u80bf\u7624\u7684\u4f53\u5185\u8367\u5149\u6210\u50cf\uff080-24\u5c0f\u65f6\uff09\u548c\u751f\u7269\u53d1\u5149\u6210\u50cf\uff0836\u5c0f\u65f6\uff09 b\uff09DIR\u6807\u8bb0\u7684\u7ec6\u83cc\u7684\u4f53\u5185\u8367\u5149\u6210\u50cf\uff080-24\u5c0f\u65f6\uff09\u548c\u539f\u4f4dCT26\u8377\u7624\u5c0f\u9f20\u4e0d\u540c\u5668\u5b98\u7684\u751f\u7269\u53d1\u5149\u6210\u50cf\uff0836\u5c0f\u65f6\uff09 c\uff09\u7ecf\u8fc7\u4e0d\u540c\u6cbb\u7597\u7684\u5c0f\u9f20\u539f\u4f4dCT26\u80bf\u7624\u7684\u4f53\u5185\u751f\u7269\u53d1\u5149\u6210\u50cf d\uff09\u4e0d\u540c\u6cbb\u7597\u65b9\u5f0f\u7684\u7ed3\u80a0\u5185\u539f\u4f4dCT26\u80bf\u7624\u7684H\uff06E\u67d3\u8272\u56fe\u50cf\u548c\u7167\u7247 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Engineered Platelets Attracted by Bacteria-Induced Tumor-Specific Blood Coagulation for Checkpoint Inhibitor Immunotherapy, <strong><b>Adv. 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Mater.<\/b><\/strong>,<em>\u00a0<\/em>2021, DOI:10.1002\/adfm.202009744<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4tt\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u901a\u5e38\uff0c\u65e0\u5e8f\u7684\u80bf\u7624\u5fae\u73af\u5883\u4f34\u968f\u7740\u7f3a\u6c27\uff0c\u8fc7\u8425\u517b\u5316\u548c\u514d\u75ab\u8d66\u514d\uff0c\u8fd9\u53ef\u4ee5\u4e3a\u7ec6\u83cc\uff0c\u5c24\u5176\u662f\u517c\u6027\u538c\u6c27\u83cc\u63d0\u4f9b\u751f\u5b58\u7a7a\u95f4\u3002\u56e0\u6b64\uff0c\u7ec6\u83cc\u975e\u5e38\u9002\u5408\u7528\u4e8e\u51c6\u786e\u533a\u5206\u80bf\u7624\u7ec4\u7ec7\u548c\u6b63\u5e38\u7ec4\u7ec7\u3002\u57fa&#8230;<\/p>\n","protected":false},"author":7336,"featured_media":220313,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[75],"class_list":["post-220312","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-biomaterial"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/220312"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=220312"}],"version-history":[{"count":2,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/220312\/revisions"}],"predecessor-version":[{"id":220487,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/220312\/revisions\/220487"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/220313"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=220312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=220312"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=220312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}