{"id":219382,"date":"2021-03-28T06:30:29","date_gmt":"2021-03-27T22:30:29","guid":{"rendered":"\/\/m.iemloyee.com\/?p=219382"},"modified":"2021-03-27T21:56:05","modified_gmt":"2021-03-27T13:56:05","slug":"%e3%80%90%e5%9b%bd%e5%a4%96%e3%80%91robert-langer%e7%9a%84%e6%96%b0%e5%86%a0%e4%bc%a0%e6%9f%93%e5%a4%a7%e6%8f%ad%e7%a7%98%e5%91%bc%e5%87%ba%e6%b0%94%e6%ba%b6%e8%83%b6%e4%b8%8ecovid-19%e6%84%9f","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=219382","title":{"rendered":"Robert Langer\u7684\u65b0\u51a0\u4f20\u67d3\u5927\u63ed\u79d8:\u547c\u51fa\u6c14\u6eb6\u80f6\u4e0eCOVID-19\u611f\u67d3\u4e0e\u4eba\u4f53\u751f\u7406\u53d8\u5316"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u4e25\u91cd\u7684\u6025\u6027\u547c\u5438\u7cfb\u7edf\u7efc\u5408\u75c7\u51a0\u72b6\u75c5\u6bd22\uff08SARS-CoV-2\uff09\u901a\u8fc7\u4eba\u4eec\u54b3\u55fd\u6216\u6253\u55b7\u568f\u65f6\u547c\u51fa\u7684\u5927\u6db2\u6ef4\u548c\u4eba\u4eec\u81ea\u7136\u547c\u5438\u65f6\u5728\u5176\u547c\u5438\u9053\u4e2d\u4ea7\u751f\u7684\u5f88\u5c0f\u7684\u6db2\u6ef4\u7684\u7ec4\u5408\u5728\u7a7a\u6c14\u4e2d\u4f20\u64ad\u3002\u4eba\u4eec\u5bf9\u547c\u51fa\u7684\u547c\u5438\u9053\u98de\u6cab\u5982\u4f55\u5728\u4e2a\u4f53\u4e4b\u95f4\u53d1\u751f\u53d8\u5316\uff0c\u5728\u4e2a\u4f53\u5185\u968f\u65f6\u95f4\u53d8\u5316\u4ee5\u53ca\u968f\u7740COVID-19\u611f\u67d3\u7684\u53d1\u4f5c\u548c\u8fdb\u5c55\u800c\u53d1\u751f\u53d8\u5316\u7684\u4e86\u89e3\u5f88\u5c11\uff0c\u4f46\u5bf9\u4e8e\u5f04\u6e05COVID-19\u4f20\u64ad\u7684\u6027\u8d28\u4ee5\u53ca\u5176\u4ed6\u9ad8\u5ea6\u4f20\u67d3\u6027\u7684\u7a7a\u6c14\u4f20\u64ad\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u81f3\u5173\u91cd\u8981\uff0c\u4f8b\u5982\u6d41\u611f\u548c\u7ed3\u6838\u75c5\uff08TB\uff09\u3002\u5f53\u6211\u4eec\u547c\u5438\uff0c\u8bf4\u8bdd\uff0c\u54b3\u55fd\u548c\u6253\u55b7\u568f\u65f6\uff0c\u4e0a\u547c\u5438\u9053\u4e2d\u5feb\u901f\u6c14\u6d41\u7684\u4f5c\u7528\u4f1a\u5bfc\u81f4\u547c\u51fa\u6c14\u4e2d\u547c\u5438\u9053\u98de\u6cab\u7684\u4ea7\u751f\u3002\u5728\u6b63\u5e38\u547c\u5438\u8fc7\u7a0b\u4e2d\uff0c\u5728\u5438\u6c14\u6d41\u91cf\u8fbe\u5230\u5cf0\u503c\u65f6\uff0c\u6c14\u7ba1\u548c\u4e3b\u652f\u6c14\u7ba1\u4e2d\u7684\u7a7a\u6c14\u901f\u5ea6\u53ef\u8fbe\u5230\u6e4d\u6d41\u901f\u5ea6\u3002\u6c14\u9053\u886c\u91cc\u7684\u7a00\u8584\u7c98\u6db2\u5c42\uff085\u03bcm\u81f310\u03bcm\uff09\u4e0a\u7684\u6025\u6d41\u4f1a\u5c06\u7c98\u6db2\u8868\u9762\u7834\u788e\u6210\u5c0f\u6ef4\uff0c\u5c31\u50cf\u5f3a\u98ce\u5728\u6d77\u9762\u4ea7\u751f\u5206\u88c2\u5e76\u55b7\u5411\u6d77\u6d0b\u8868\u9762\u4e00\u6837\u3002\u8fd9\u79cd\u6db2\u6ef4\u7834\u88c2\u7684\u6027\u8d28\u548c\u7a0b\u5ea6\u53d6\u51b3\u4e8e\u7c98\u6db2\u672c\u8eab\u7684\u8868\u9762\u6027\u8d28\u3002\u5728\u6700\u5f71\u54cd\u6db2\u6ef4\u4ea7\u751f\u548c\u6db2\u6ef4\u5c3a\u5bf8\u7684\u7279\u6027\u4e2d\uff0c\u8868\u9762\u7c98\u5f39\u6027\u548c\u8868\u9762\u5f20\u529b\u662f\u6700\u91cd\u8981\u7684\u3002\u5728\u6c14\u9053\u886c\u91cc\u7c98\u6db2\u4e2d\uff0c\u8fd9\u4e24\u79cd\u6027\u8d28\u90fd\u968f\u80ba\u8868\u9762\u6d3b\u6027\u5242\u7684\u7c7b\u578b\u548c\u6d53\u5ea6\u4ee5\u53ca\u7d27\u9760\u7a7a\u6c14\u8868\u9762\u7684\u7c98\u6db2\u7684\u7ec4\u6210\u548c\u7ed3\u6784\u800c\u53d8\u5316\u3002\u56e0\u6b64\uff0c\u8868\u9762\u6d3b\u6027\u5242\u548c\u7c98\u86cb\u767d\u7684\u7ec4\u6210\u548c\u7ed3\u6784\u53d8\u5316\uff0c\u90e8\u5206\u662f\u53d7\u4eba\u7c7b\u72b6\u51b5\u7684\u751f\u7406\u53d8\u5316\uff08\u5305\u62ec\u996e\u98df\uff0c\u8870\u8001\u548cCOVID-19\u611f\u67d3\u672c\u8eab\uff09\u7684\u9a71\u52a8\uff0c\u56e0\u6b64\u53ef\u4ee5\u9884\u671f\u5728\u547c\u5438\u8fc7\u7a0b\u4e2d\u4f1a\u6539\u53d8\u6db2\u6ef4\u7684\u4ea7\u751f\u548c\u6db2\u6ef4\u7684\u5927\u5c0f\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u00a0<\/b><\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0<\/b><\/strong>\u00a0COVID-19\u901a\u8fc7\u547c\u5438\u8fc7\u7a0b\u4e2d\u4ece\u547c\u5438\u9053\u7c98\u6db2\u8868\u9762\u4ea7\u751f\u7684\u5c0f\u6ef4\u4f20\u64ad\uff0c\u8be5\u8fc7\u7a0b\u5728\u53d7\u4e25\u91cd\u6025\u6027\u547c\u5438\u7cfb\u7edf\u7efc\u5408\u75c7\u51a0\u72b6\u75c5\u6bd22\uff08SARS-CoV-2\uff09\u75c5\u6bd2\u611f\u67d3\u7684\u5bbf\u4e3b\u5185\u8fdb\u884c\u3002Robert Langer&David Edwards&Chad Roy<\/b><\/strong>\u7814\u7a76\u4e86\u6709\u548c\u6ca1\u6709COVID-19\u611f\u67d3\u7684\u4eba\u7c7b\u548c\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\u7684\u547c\u5438\u9053\u6db2\u6ef4\u7684\u4ea7\u751f\u548c\u547c\u51fa\uff0c\u4ee5\u63a2\u8ba8SARS-CoV-2\u611f\u67d3\u4ee5\u53ca\u751f\u7406\u72b6\u6001\u7684\u5176\u4ed6\u53d8\u5316\u662f\u5426\u8f6c\u5316\u4e3a\u53ef\u89c2\u5bdf\u5230\u7684\u547c\u51fa\u547c\u5438\u9053\u6db2\u6ef4\u7684\u6570\u91cf\u548c\u5927\u5c0f\u7684\u6f14\u53d8\u3002\u5728\u89c2\u5bdf\u6027\u961f\u5217\u7814\u7a76\u4e2d\uff0c\u5bf9194\u540d\u5065\u5eb7\u4eba\u7684\u547c\u51fa\u6c14\u9897\u7c92\u8fdb\u884c\u4e86\u89c2\u5bdf\uff0c\u5e76\u5728\u5b9e\u9a8c\u4e2d\u7814\u7a76\u4e868\u4f8b\u88abSARS-CoV-2\u6c14\u6eb6\u80f6\u611f\u67d3\u7684\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\uff1a\u5728\u53d7\u8bd5\u8005\u4e4b\u95f4\u547c\u51fa\u7684\u6c14\u6eb6\u80f6\u9897\u7c92\u4e4b\u95f4\u5b58\u5728\u4e09\u4e2a\u6570\u91cf\u7ea7\u7684\u5dee\u5f02\u7684\u6570\u91cf\u7ea7\uff0c\u547c\u51fa\u7684\u547c\u5438\u98de\u6cab\u6570\u91cf\u968fCOVID-19\u611f\u67d3\u7a0b\u5ea6\u548cBMI\u5e74\u6570\u7684\u5347\u9ad8\u800c\u589e\u52a0\u3002\u5b9e\u9a8c\u89c2\u5bdf\u523018\uff05\u7684\u4eba\u7c7b\u53d7\u8bd5\u8005\uff0835\uff09\u5360\u4e86\u8be5\u7ec4\u547c\u51fa\u7684\u751f\u7269\u6c14\u96fe\u5242\uff08194\uff09\u768480\uff05\uff0c\u8fd9\u53cd\u6620\u4e86\u751f\u7269\u6c14\u96fe\u5242\u7684\u8d85\u7ea7\u6269\u6563\u5668\u5206\u5e03\uff0c\u7c7b\u4f3c\u4e8e\u7ecf\u5178\u768420:80\u611f\u67d3\u5206\u5e03\u7684\u8d85\u7ea7\u6269\u6563\u5668\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u5728\u7f3a\u4e4f\u6709\u6548\u4e14\u5e7f\u6cdb\u4f20\u64ad\u7684\u75ab\u82d7\u7684\u60c5\u51b5\u4e0b\uff0c\u5bf9\u547c\u51fa\u6c14\u6eb6\u80f6\u7684\u5b9a\u91cf\u8bc4\u4f30\u548c\u63a7\u5236\u5bf9\u4e8e\u51cf\u6162COVID-19\u5728\u7a7a\u6c14\u4e2d\u7684\u4f20\u64ad\u53ef\u80fd\u81f3\u5173\u91cd\u8981\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201c<\/b><\/strong>Exhaled aerosol increases with COVID-19 infection,<\/b><\/strong><\/p>\n

age, and obesity<\/b><\/strong>\u201d<\/b><\/strong>\u53d1\u8868\u5728PNAS<\/b><\/strong>\u4e0a<\/b><\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

Fi<\/b><\/strong>gure <\/b><\/strong>1.No Evil Foods\u768474\u540d\u57fa\u672c\u5de5\u4eba\u548c\u5927\u6025\u6d41\u57ce\u793e\u533a\u5b66\u9662\u7684120\u540d\u5fd7\u613f\u8005\u7684\u547c\u6c14\u9897\u7c92\u7269<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u6240\u6709\u53c2\u52a0\u8005\u00a0\uff08B\uff09\u201c\u8d85\u7ea7\u4f20\u64ad\u8005\u201d\u53c2\u4e0e\u8005\uff08C\uff09\u201c\u8d85\u7ea7\u6563\u5e03\u8005\u201d\u53c2\u4e0e\u8005\uff1b\uff08\u56db\uff09\u201c\u4f4e\u4f20\u64ad\u201d\u53c2\u4e0e\u8005<\/p>\n

Figure 2.\u547c\u6c14\u5fae\u7c92\u4e0eBMI\u3001\u5e74\u9f84\u7684\u51fd\u6570\u5173\u7cfb<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure 3.\u5728\u5b9e\u9a8c\u611f\u67d3\u7684\u7315\u7334\uff08RM\uff09\u548c\u975e\u6d32\u7eff\u7334\uff08AGM\uff09\u4e2d\u547c\u51fa\u7684\u547c\u5438\u9897\u7c92\u548c\u76f8\u5e94\u7684\u57fa\u56e0\u7ec4SARS-CoV-2\u75c5\u6bd2RNA<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure 4.\u5b9e\u9a8c\u611f\u67d3\u7684\u6052\u6cb3\u7334\uff08RM\uff09\u548c\u975e\u6d32\u7eff\u7334\uff08AGM\uff09\u7684\u547c\u51fa\u6c14\u9897\u7c92\u548c\u76f8\u5e94\u7684\u7c92\u5f84\u5206\u5e03<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure 5.\u611f\u67d3\u4e86Mtb\u7684\u7315\u7334\uff08n = 4\uff09\u7684\u547c\u51fa\u6c14\u9897\u7c92\u548c\u76f8\u5e94\u7684\u7c92\u5f84\u5206\u5e03<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u3010<\/b><\/strong>\u5c0f\u7ed3<\/b><\/strong>\u3011<\/b><\/strong><\/p>\n

NHP\u4e2dCOVID-19\u611f\u67d3\u9ad8\u5cf0\u671f\u5c0f\u547c\u5438\u9053\u5c0f\u6db2\u6ef4\u7684\u6bd4\u4f8b\u589e\u52a0\uff0c\u8fd9\u8bc1\u5b9e\u4e86\u5148\u524d\u53d1\u8868\u7684\u5355\u4e2aCOVID-19\u9633\u6027\u4eba\u7c7b\u53d7\u8bd5\u8005\u547c\u51fa\u6c14\u6eb6\u80f6\u66f2\u7ebf\u7684\u89c2\u5bdf\u7ed3\u679c\uff0c\u5e76\u8868\u660e\u5728\u9ad8\u5cf0\u671f\u611f\u67d3\u53ef\u80fd\u7531\u4e8e\u901a\u8fc7\u4f20\u7edf\u53e3\u7f69\u548c\u975e\u5e38\u8fdc\u8d85\u8fc72 m\u7684\u5e38\u89c4\u793e\u4ea4\u8ddd\u79bb\u7684\u4f20\u64ad\u8ddd\u79bb\u7684\u975e\u5e38\u5c0f\u7684\u6db2\u6ef4\uff0cSARS-CoV-2\u5728\u7a7a\u4e2d\u4f20\u64ad\u7684\u98ce\u9669\u8f83\u9ad8\u3002\u5bf9COVID-19\u5927\u6d41\u884c\u7684\u79d1\u5b66\u53cd\u5e94\u4e3b\u8981\u96c6\u4e2d\u5728\u5f00\u53d1\u6cbb\u7597\u6027\u836f\u7269\u548c\u9884\u9632\u6027\u75ab\u82d7\u4e0a\u3002\u5728\u7b49\u5f85\u6cbb\u6108\u6216\u5e7f\u6cdb\u91c7\u7528\u7684\u6709\u6548\u75ab\u82d7\u4e4b\u524d\uff0c\u79d1\u5b66\u754c\u53ef\u80fd\u5efa\u8bae\u901a\u8fc7\u6062\u590d\u6c14\u9053\u5185\u886c\u7c98\u6db2\u5c4f\u969c\u529f\u80fd\uff0c\u7279\u522b\u662f\u964d\u4f4e\u5176\u503e\u5411\u6027\uff0c\u96c6\u4e2d\u7cbe\u529b\u7ba1\u7406COVID-19\u3002\u6c14\u9053\u5185\u886c\u7c98\u6db2\u5728\u81ea\u7136\u547c\u5438\u7684\u4f5c\u7528\u4e0b\u4f1a\u5206\u89e3\uff0c\u5426\u5219\u4e0d\u5e0c\u671b\u5728\u672a\u611f\u67d3\u548c\u672a\u611f\u67d3\u7684\u5e74\u8f7b\u4eba\u7684\u6c14\u9053\u4e2d\u53d1\u751f\u3002\u547c\u51fa\u7684\u6c14\u6eb6\u80f6\u6570\u91cf\u4f3c\u4e4e\u4e0d\u4ec5\u662f\u75be\u75c5\u8fdb\u5c55\u7684\u6307\u6807\uff0c\u800c\u4e14\u8fd8\u662f\u672a\u611f\u67d3\u4e2a\u4f53\u4e2d\u75be\u75c5\u98ce\u9669\u7684\u6807\u5fd7\u3002\u76d1\u6d4b\uff08\u4f5c\u4e3a\u8bca\u65ad\u624b\u6bb5\uff09\u4e5f\u53ef\u80fd\u662f\u63a7\u5236COVID-19\u548c\u5176\u4ed6\u547c\u5438\u9053\u4f20\u67d3\u75c5\uff08\u5305\u62ec\u7ed3\u6838\u75c5\u548c\u6d41\u611f\uff09\u7684\u4f20\u64ad\u548c\u611f\u67d3\u65f6\u8981\u8003\u8651\u7684\u91cd\u8981\u7b56\u7565\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/b><\/strong>\uff1aExhaled aerosol increases with COVID-19 infection,<\/p>\n

age, and obesity, PN<\/b><\/strong>AS<\/b><\/strong>,\u00a0<\/i><\/em>2021, DOI:10.1073\/pnas.2021830118<\/p>\n

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