{"id":218990,"date":"2021-03-13T06:11:59","date_gmt":"2021-03-12T22:11:59","guid":{"rendered":"\/\/m.iemloyee.com\/?p=218990"},"modified":"2021-03-12T22:12:13","modified_gmt":"2021-03-12T14:12:13","slug":"%e6%96%b0%e5%8a%a0%e5%9d%a1%e5%9b%bd%e7%ab%8b%e5%a4%a7%e5%ad%a6%e5%88%98%e6%96%8cadv-funct-mater-%e5%85%b7%e6%9c%89%e8%82%bf%e7%98%a4%e6%bf%80%e6%b4%bb%e7%9a%84%e5%85%89%e6%95%8f%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=218990","title":{"rendered":"\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5218\u658cAdv. Funct. Mater.:\u5177\u6709\u80bf\u7624\u6fc0\u6d3b\u7684\u5149\u654f\u4f5c\u7528\u548c\u5c3a\u5bf8\u8f6c\u53d8\u7279\u6027\u7684\u7eb3\u7c73\u836f\u7269"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u5149\u52a8\u529b\uff08PDT\uff09\u4e0e\u5316\u7597\u8054\u5408\u6cbb\u7597\u8fd1\u671f\u88ab\u8bc1\u660e\u662f\u4e00\u79cd\u975e\u5e38\u6709\u524d\u666f\u7684\u764c\u75c7\u7597\u6cd5\uff0c\u56e0\u5176\u80fd\u63d0\u9ad8\u5355\u4e00PDT\u7684\u6cbb\u7597\u6548\u679c\uff0c\u8bf1\u5bfc\u4ea7\u751f\u6297\u80bf\u7624\u514d\u75ab\u529b\u5e76\u9006\u8f6c\u80bf\u7624\u591a\u836f\u8010\u836f\u6027\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u53d1\u5c55\u6210\u50cf\u5f15\u5bfc\u7684\u5149\u52a8\u529b-\u5316\u7597\u8054\u5408\u6cbb\u7597\uff0c\u7814\u7a76\u4eba\u5458\u8fd1\u671f\u5f00\u53d1\u4e86\u4e00\u7cfb\u5217\u5177\u6709\u660e\u4eae\u8fdc\u7ea2\uff08FR\uff09\/\u8fd1\u7ea2\u5916\uff08NIR\uff09\u53d1\u5c04\u7684\u9ad8\u6548\u5149\u654f\u5242\uff08PSs\uff09\u3002\u4f46\u662f\uff0c\u5305\u62ec\u81f4\u5bc6\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u548c\u9ad8\u7ec6\u80de\u5806\u79ef\u5bc6\u5ea6\u5728\u5185\u7684\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e0d\u5229\u4e8ePSs\u548c\u5316\u7597\u836f\u7269\u5728\u7624\u5185\u7684\u9012\u9001\u3002\u8fd9\u4e9b\u5c4f\u969c\u5bf9\u6297\u764c\u836f\u7269\u5728\u7624\u5185\u5bcc\u96c6\u548c\u7a7f\u900f\u5747\u4ea7\u751f\u8d1f\u9762\u5f71\u54cd\uff0c\u65e0\u6cd5\u5145\u5206\u5229\u7528\u836f\u7269\u6f5c\u5728\u7684\u7ec6\u80de\u6740\u4f24\u6548\u529b\u3002\u53e6\u5916\uff0c\u6b63\u5e38\u7ec4\u7ec7\u7684\u975e\u7279\u5f02\u6027\u6444\u53d6\u4e5f\u9650\u5236\u4e86\u5b83\u4eec\u5728\u5149\u52a8\u529b-\u5316\u7597\u8054\u5408\u6cbb\u7597\u4e2d\u7684\u7597\u6548\u3002\u4e0e\u5c3a\u5bf8\u8f83\u5927\u7684\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\uff08NP\uff09\u548c\u6ca1\u6709\u805a\u5408\u7269\u5305\u5c01\u7684\u5206\u5b50\u805a\u96c6\u4f53\u76f8\u6bd4\uff0c\u5c3a\u5bf8\u8f83\u5c0f\u7684\u805a\u5408\u7269NP\uff08<50 nm\uff09\u5df2\u88ab\u8bc1\u660e\u5bf9\u80bf\u7624\u8840\u7ba1\u5916\u6e17\u4f4d\u70b9\u548c\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u7c98\u9644\u529b\u6700\u5c0f\uff0c\u6700\u6709\u5229\u4e8e\u7624\u5185\u7a7f\u900f\u3002\u4f46\u662f\uff0c\u5927\u5c0f\u4e3a100-200 nm\u7684\u805a\u5408\u7269NP\u901a\u8fc7\u5b9e\u4f53\u7624\u7684\u9ad8\u901a\u900f\u6027\u548c\u6ede\u7559\u6548\u5e94\u800c\u5177\u6709\u8f83\u9ad8\u7684\u80bf\u7624\u5bcc\u96c6\u3002 \u5173\u4e8eNP\u5927\u5c0f\u7684\u8fd9\u79cd\u77db\u76fe\u4ee4\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u51fa\u4e86\u65b0\u578b\u57fa\u4e8e\u805a\u5408\u7269\u5927\u5c0f\u53ef\u53d8\u7684\u7eb3\u7c73\u836f\u7269\uff0c\u8be5\u7c7b\u836f\u7269\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u5728\u7624\u5185\u7531\u5927\u53d8\u5c0f\uff0c\u4ece\u800c\u63d0\u9ad8\u4e86\u5176\u5728\u7624\u5185\u7684\u5bcc\u96c6\u548c\u7a7f\u900f\u3002\u7136\u800c\uff0c\u5927\u5c0f\u53ef\u53d8\u7684\u805a\u5408\u7269NP\u4ecd\u7136\u9762\u4e34TME\u4e2d\u7684\u8bf8\u591a\u751f\u7269\u5c4f\u969c\u3002\u56e0\u6b64\uff0c\u5c06\u5c3a\u5bf8\u53ef\u53d8\u4e0e\u80bf\u7624\u8868\u9762\u6709\u6548\u7684\u7ec6\u80de\u6740\u4f24\u80fd\u529b\u6574\u5408\u5728\u4e00\u8d77\u5bf9\u805a\u5408\u7269NP\u6253\u7834\u836f\u7269\u9012\u9001\u7684\u751f\u7269\u5c4f\u969c\u975e\u5e38\u91cd\u8981\uff0c\u80fd\u591f\u589e\u5f3a\u805a\u5408\u7269NP\u5728\u7624\u5185\u7684\u5bcc\u96c6\u548c\u7a7f\u900f\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u6574\u5408\u5f88\u5177\u6709\u6311\u6218\u6027\uff0c\u8fc4\u4eca\u4e3a\u6b62\u9c9c\u6709\u62a5\u9053\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u00a0<\/b><\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0<\/b><\/strong>\u00a0\u5177\u6709\u826f\u597d\u80bf\u7624\u7a7f\u900f\u7684\u6297\u764c\u836f\u7269\u5728\u7624\u5185\u7684\u6709\u6548\u5206\u5e03\u5bf9\u4e8e\u5149\u52a8\u529b\uff08PDT\uff09\u4e0e\u5316\u7597\u8054\u5408\u6cbb\u7597\u5177\u6709\u91cd\u8981\u7684\u73b0\u5b9e\u610f\u4e49\u3002\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5218\u658c<\/b><\/strong>\u62a5\u9053\u4e86\u91d1\u5c5e\u6709\u673a\u6846\u67b6\uff08MOF\uff09\u8f85\u52a9\u7b56\u7565\uff0c\u5bf9\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\u5149\u654f\u5242\uff08AIE PS\uff09\u548c\u5316\u7597\u836f\u7269\u7684\u8fdb\u884c\u4e86\u667a\u80fd\u9012\u9001\uff0c\u8fdb\u800c\u5b9e\u73b0\u4e86\u80bf\u7624\u6df1\u7a7f\u900f\u548c\u9ad8\u6548\u7684\u6210\u50cf\u5f15\u5bfc\u5149\u52a8\u529b-\u5316\u7597\u8054\u5408\u6cbb\u7597\u3002\u5176\u4e2d\uff0c\u65b0\u578bAIE PS\u88ab\u5c01\u88c5\u5728\u94c1\u57fa\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\uff08MIL-100\uff09\u4e2d\uff0c\u4ee5\u751f\u4ea7PS@MIL-100\uff0c\u540e\u7ecf\u963f\u9709\u7d20\uff08Dox\uff09\u5171\u8f6d\u76f8\u8fde\u7684\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u5305\u8986\u4e3a\u76f4\u5f84\u4e3a120 nm\u7684Dox-PEG-PS@MIL\u7eb3\u7c73\u9897\u7c92\uff08NPs\uff09\u3002\u5728Dox-PEG-PS@MIL NPs\u5230\u8fbe\u80bf\u7624\u90e8\u4f4d\u540e\uff0c\u80bf\u7624\u5185H2O2\u5f15\u8d77\u8d1f\u8f7d\u7684PS\u4e8e\u80bf\u7624\u8868\u9762\u91ca\u653e\uff0c\u5b9e\u73b0\u53ef\u6fc0\u6d3b\u7684\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\uff1b\u540c\u65f6\u89e6\u53d1Dox-PEG\u7247\u6bb5\u81ea\u7ec4\u88c5\u4e3a\u8d85\u5c0f\u578bDox NPs\u3002\u5149\u7167\u4e0b\uff0cPDT\u5728\u80bf\u7624\u8868\u9762\u88ab\u6fc0\u6d3b\uff0c\u534f\u540c\u589e\u5f3a\u8d85\u5c0f\u578bDox NPs\u7684\u7624\u5185\u7a7f\u900f\u3002 Dox NPs\u88ab\u764c\u7ec6\u80de\u6444\u53d6\u540e\uff0cDox\u4e8e\u4f4epH\u73af\u5883\u4e2d\u4eceDox NPs\u91ca\u653e\u8fdb\u5165\u7ec6\u80de\u6838\uff0c\u4ece\u800c\u8fdb\u884c\u9ad8\u6548\u7684\u5316\u7597\u3002\u540c\u65f6\uff0cPS\u53d1\u51fa\u8fdc\u7ea2\u5916\/\u8fd1\u7ea2\u5916\u5149\uff0c\u5b9e\u73b0\u4e86\u6210\u50cf\u5f15\u5bfc\u7684\u589e\u5f3a\u578b\u5149\u52a8\u529b-\u5316\u7597\u8054\u5408\u6cbb\u7597\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201c<\/b><\/strong>Tumor-Activated Photosensitization and Size Transformation of Nanodrugs<\/b><\/strong>\u201d<\/b><\/strong>\u53d1\u8868\u5728Adv. Funct. Mater.<\/b><\/strong>\u4e0a<\/b><\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

Scheme <\/b><\/strong>1<\/b><\/strong>.\u7eb3\u7c73\u7c92\u5b50\u7684\u80bf\u7624\u6cbb\u7597\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

A\uff09Dox-PEG-PS@MIL-100 NPs\u7684MIL-100\u7ed3\u6784\u574d\u584c (I)\uff0cPS\u91ca\u653e\uff08II\uff09\u548cDox-PEG\u81ea\u7ec4\u88c5\uff08III\uff09\u4ee5\u53ca\u7eb3\u7c73\u9897\u7c92\u5c3a\u5bf8\u51cf\u5c0f\u548cPDT\u8f85\u52a9\u7684\u80bf\u7624\u6df1\u7a7f\u900f\uff1bB\uff09I\uff0cII\u548cIII\u8fc7\u7a0b\u540e\uff0cDox-PEG-PS@MIL-100 NPs\u7684\u654f\u5316\u548c\u5c3a\u5bf8\u51cf\u5c0f\u7684\u53cc\u91cd\u6fc0\u6d3b\uff0c\u4ee5\u5b9e\u73b0\u7624\u5185\u6df1\u7a7f\u900f\uff0c\u4ece\u800c\u8fdb\u884c\u9ad8\u6548\u7684\u6210\u50cf\u5f15\u5bfc\u7684\u5149\u52a8\u529b-\u5316\u7597\u8054\u5408\u6cbb\u7597<\/p>\n

Figure 1<\/b><\/strong>.<\/b><\/strong>PS\u548c\u7eb3\u7c73\u7c92\u5b50\u7684\u7406\u5316\u6027\u8d28<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure 2<\/b><\/strong>.<\/b><\/strong>\u7eb3\u7c73\u7c92\u5b50\u7684\u5c3a\u5bf8\u53d8\u5316<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure 3.\u7ec6\u80de\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure 4.\u7ec6\u80de\u6c34\u5e73\u4e0a\u7eb3\u7c73\u7c92\u5b50\u7684\u7597\u6548<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure 5.\u5c0f\u9f20\u6d3b\u4f53\u6cbb\u7597<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u3010<\/b><\/strong>\u5c0f\u7ed3<\/b><\/strong>\u3011<\/b><\/strong><\/p>\n

\u4f5c\u8005\u5f00\u53d1\u4e86Dox-PEG-PS@MIL-100 NPs\u7528\u4e8e\u53ef\u6fc0\u6d3b\u7684\u5149\u654f\u5316\u548c\u7eb3\u7c73\u7c92\u5b50\u5c3a\u5bf8\u51cf\u5c0f\u8fc7\u7a0b\uff0c\u8fdb\u800c\u5728\u6df1\u5c42\u80bf\u7624\u5904\u5b9e\u73b0\u9ad8\u6548\u7684\u5149\u52a8\u529b-\u5316\u7597\u8054\u5408\u6cbb\u7597\u3002\u4f53\u5916\u548c\u4f53\u5185\u8bc4\u4f30\u8868\u660eDox-PEG-PS@MIL-100 NPs\u88ab\u80bf\u7624\u6444\u53d6\u540e\uff0c\u80fd\u591f\u9009\u62e9\u6027\u88ab\u7624\u5185H2O2\u89e3\u79bb\uff0c\u5728\u80bf\u7624\u8868\u9762\u91ca\u653e\u8d1f\u8f7d\u7684AIE PS\uff0c\u4ece\u800c\u6fc0\u6d3bPDT\u3002\u540c\u65f6\uff0cDox-PEG-PS@MIL-100 NPs\u4e2dDox-PEG\u53ef\u81ea\u7ec4\u88c5\u5f62\u6210\u8d85\u5c0f\u578bDox NPs\uff0c\u4ee5\u5b9e\u73b0\u6df1\u5c42\u80bf\u7624\u7a7f\u900f\u3002\u5149\u7167\u4e0b\uff0cAIE PS\u5728\u80bf\u7624\u8868\u9762\u80fd\u591f\u8fdb\u884c\u6709\u6548\u7684\u764c\u7ec6\u80de\u6740\u4f24\uff0c\u534f\u540c\u589e\u5f3a\u4e86Dox NPs\u5728\u80bf\u7624\u4e2d\u7684\u5bcc\u96c6\u548c\u7a7f\u900f\u3002Dox NPs\u5728\u88ab\u764c\u7ec6\u80de\u6444\u53d6\u540e\uff0c\u4e8e\u4f4epH\u73af\u5883\u4e0b\u91ca\u653eDox\uff0c\u4ee5\u4f7f\u5176\u8fdb\u5165\u7ec6\u80de\u6838\u8fdb\u884c\u9ad8\u6548\u7684\u5316\u7597\u3002\u8fde\u540cAIE PS\u660e\u4eae\u7684FR\/NIR\u53d1\u5c04\uff0c\u6210\u50cf\u5f15\u5bfc\u7684\u5149\u52a8\u529b-\u5316\u7597\u8054\u5408\u6cbb\u7597\u56e0\u6b64\u901a\u8fc7PS\u548c\u8d85\u5c0f\u578b\u836f\u7269NP\u7684\u53cc\u91cd\u6fc0\u6d3b\u800c\u5f97\u4ee5\u5b9e\u73b0\u3002MOF\u8f85\u52a9\u7b56\u7565\u5c06\u4e3aPDT\u548c\u5c3a\u5bf8\u51cf\u5c0f\u8f85\u52a9\u7684\u5316\u7597\u836f\u7269\u9012\u9001\u94fa\u5e73\u9053\u8def\uff0c\u4ee5\u5b9e\u73b0\u5148\u8fdb\u7684\u5149\u52a8\u529b-\u5316\u7597\u8054\u5408\u6cbb\u7597\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/b><\/strong>\uff1aTumor-Activated Photosensitization and Size Transformation of Nanodrugs, Adv. Funct. Mater.<\/b><\/strong>,\u00a0<\/i><\/em>2021, DOI:10.1002\/adfm.202010241<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4tt\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

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