{"id":216652,"date":"2021-01-26T06:25:55","date_gmt":"2021-01-25T22:25:55","guid":{"rendered":"\/\/m.iemloyee.com\/?p=216652"},"modified":"2021-01-25T22:26:09","modified_gmt":"2021-01-25T14:26:09","slug":"%e6%9e%97%e6%96%87%e6%96%8c%e7%ad%89%e4%ba%ba-jacs%ef%bc%9a%e9%a6%96%e6%ac%a1%e6%8a%a5%e9%81%93%ef%bc%81%e7%ba%b3%e7%b1%b3%e7%ba%a7mols%e5%90%8c%e6%97%b6%e6%b5%8b%e5%ae%9agsh%e5%92%8cph%ef%bc%8c","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=216652","title":{"rendered":"\u6797\u6587\u658c\u7b49\u4eba JACS\uff1a\u9996\u6b21\u62a5\u9053\uff01\u7eb3\u7c73\u7ea7MOLs\u540c\u65f6\u6d4b\u5b9aGSH\u548cpH\uff0c\u4ee5\u68c0\u6d4b\u7ebf\u7c92\u4f53\u5931\u8c03\u548c\u5316\u7597\u8010\u836f\u6027"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u7ebf\u7c92\u4f53\u662f\u7ec6\u80de\u7684\u80fd\u91cf\u6765\u6e90\uff0c\u5176\u5bf9\u8bb8\u591a\u6f5c\u5728\u7684\u6709\u5bb3\u5206\u5b50\u8fdb\u884c\u4e25\u683c\u7684\u4f53\u5185\u5e73\u8861\u63a7\u5236\u3002\u82e5\u7ebf\u7c92\u4f53\u5185\u7a33\u6001\u5931\u8c03\uff0c\u5219\u53ef\u4ee5\u963b\u6b62\u7ec6\u80de\u589e\u6b96\u5e76\u5f15\u8d77\u7ec6\u80de\u6b7b\u4ea1\u3002\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u662f\u4e00\u79cd\u7ef4\u6301\u7ec6\u80de\u6c27\u5316\u8fd8\u539f\u5e73\u8861\u7684\u6297\u6c27\u5316\u5242\uff0c\u5728\u80de\u6d46\u4e2d\u5408\u6210\u5e76\u5206\u5e03\u4e8e\u4e0d\u540c\u7684\u4e9a\u7ec6\u80de\u5ba4\u3002\u5176\u4e2d\uff0c\u7ebf\u7c92\u4f53\u5185GSH\u5728\u7ef4\u6301\u7ec6\u80de\u5b58\u6d3b\u7684\u9002\u5f53\u6c27\u5316\u8fd8\u539f\u73af\u5883\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u6b63\u5e38\u7ebf\u7c92\u4f53\u7684pH\u503c\u5448\u78b1\u6027\uff0c\u7ebf\u7c92\u4f53\u5931\u8c03\u5f71\u54cd\u79bb\u5b50\u5185\u6d41\uff0c\u5e76\u5728\u7ebf\u7c92\u4f53\u819c\u4e0a\u4ea7\u751f\u8d28\u5b50\u68af\u5ea6\uff0c\u964d\u4f4e\u7ebf\u7c92\u4f53\u57fa\u8d28\u7684pH\u503c\u3002\u56e0\u6b64\uff0c\u7ebf\u7c92\u4f53\u4e2dGSH\u548cpH\u4f20\u611f\u5668\u7684\u53d1\u5c55\u53ef\u4ee5\u63ed\u793a\u7ebf\u7c92\u4f53\u5931\u8c03\u7684\u91cd\u8981\u89c1\u89e3\uff0c\u5e76\u4e3a\u7406\u89e3\u5404\u79cd\u75c5\u7406\u751f\u7406\u8fc7\u7a0b\u63d0\u4f9b\u673a\u4f1a\u3002\u7eb3\u7c73\u7ea7\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\uff08nMOFs\uff09\u662f\u7531\u91d1\u5c5e-\u542b\u6c27\u56e2\u7c07\u4e8c\u7ea7\u7ed3\u6784\u5355\u5143\uff08SBUs\uff09\u548c\u6709\u673a\u6865\u8fde\u914d\u4f53\u6784\u5efa\u800c\u6210\uff0c\u5df2\u5e94\u7528\u4e8e\u5316\u5b66\u548c\u751f\u7269\u4f20\u611f\u9886\u57df\u3002\u7136\u800c\uff0c\u6865\u8fde\u914d\u4f53\u548cnMOFs\u7684\u5c0f\u5b54\u7684\u4e25\u683c\u5bf9\u79f0\u6027\u963b\u788d\u4e86\u5176\u591a\u529f\u80fd\u5316\uff0c\u5e76\u9650\u5236\u4e86\u5b83\u4eec\u5728\u5927\u5206\u5b50\u4f20\u611f\u4e2d\u7684\u5e94\u7528\u3002\u4f46\u662f\uff0c\u7eb3\u7c73\u7ea7\u91d1\u5c5e\u6709\u673a\u5c42\uff08nMOLs\uff09\u4e0d\u4ec5\u4fdd\u7559\u4e86nMOFs\u7684\u5206\u5b50\u53ef\u8c03\u6027\u3001\u7ed3\u6784\u89c4\u5219\u6027\u3001\u7ec4\u6210\u591a\u6837\u6027\uff0c\u800c\u4e14\u8fd8\u5177\u6709\u9ad8\u5bc6\u5ea6\u7684\u5f00\u653e\u4f4d\u70b9\uff0c\u53ef\u4ee5\u8fdb\u884c\u591a\u529f\u80fd\u5316\u548c\u5927\u578b\u5206\u6790\u7269\u7684\u68c0\u6d4b\uff0c\u4e3a\u751f\u7269\u7cfb\u7edf\u4e2d\u591a\u79cd\u5206\u6790\u7269\u7684\u6bd4\u7387\u4f20\u611f\u5668\u7684\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u4e00\u4e2a\u901a\u7528\u7684\u5e73\u53f0\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u829d\u52a0\u54e5\u5927\u5b66\u6797\u6587\u658c\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba<\/strong>\u62a5\u9053\u4e86\u4e00\u79cd\u57fa\u4e8e\u4e09\u91cd\u53d1\u5c04\u6001\u7684nMOL\u7684\u751f\u7269\u4f20\u611f\u5668\uff08NA@Zr-BTB\/F\/R\uff09\uff0c\u7528\u4e8e\u7ebf\u7c92\u4f53\u4e2d\u6bd4\u7387GSH\u548cpH\u4f20\u611f\u3002Zr-BTB-nMOL\u4e2d\u542b\u6709[Zr6<\/sub>O4<\/sub>(OH)4<\/sub>(HCO2<\/sub>)6<\/sub>] SBUs\u548c2, 4, 6-\u4e09\uff084-\u7fa7\u57fa\u82ef\u57fa\uff09\u82ef\u80fa\uff08BTB-NH2<\/sub>\uff09\u914d\u4f53\uff0c\u901a\u8fc7\u4ea4\u6362SBUs\u4e0a\u7684\u7532\u9178\u916f\u5c01\u7aef\u57fa\u56e2\u4e0eGSH\u9009\u62e9\u6027(2E)-1-\uff082\u2019-\u8418\u57fa\uff09-3-\uff084-\u7fa7\u57fa\u82ef\u57fa\uff09-2-\u4e19\u70ef-1-\u916e\uff08NA\uff09\u8fdb\u884c\u5408\u6210\u540e\u5b98\u80fd\u5316\uff0c\u5e76\u4e14\u5171\u4ef7\u7edc\u5408pH-\u654f\u611f\u7684\u5f02\u786b\u6c30\u9178\u8367\u5149\u7d20\uff08FITC\uff0cF\uff09\u548c\u4e0d\u4f9d\u8d56GSH\/pH\u7684\u7f57\u4e39\u660e-B\u5f02\u786b\u6c30\u9178\u76d0\uff08RITC\uff0cR\uff09\u5230BTB-NH2<\/sub>\u914d\u4f53\u4e0a\uff0c\u5f97\u5230NA@Zr-BTB\/F\/R\u3002\u901a\u8fc7\u8367\u5149\u6cd5\u548c\u5171\u805a\u7126\u6fc0\u5149\u626b\u63cf\u663e\u5fae\u955c\uff08CLSM\uff09\u7814\u7a76\u8868\u660e\uff0cNA@Zr-BTB\/F\/R\u53ef\u4f5c\u4e3a\u4e00\u79cd\u53ef\u9760\u3001\u51c6\u786e\u7684\u7ebf\u7c92\u4f53GSH\u548cpH\u6bd4\u7387\u4f20\u611f\u5668\uff0c\u7528\u4e8e\u68c0\u6d4b\u7ebf\u7c92\u4f53\u5931\u8c03\u548c\u5316\u7597\u8010\u836f\u6027\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cNanoscale Metal-Organic Layers Detect Mitochondrial Dysregulation and Chemoresistance via Ratiometric Sensing of Glutathione and pH\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520a J. Am. Chem. Soc.<\/strong>\u4e0a\u3002
\n \"\"
\n \u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001NA@Zr-BTB\/F\/R\u7684\u7ed3\u6784\u548c\u4f5c\u7528\u539f\u7406\u793a\u610f\u56fe<\/strong>
\n \"\"\uff08a\uff09NA@Zr-BTB\/F\/R\u7684\u7ed3\u6784\u793a\u610f\u56fe\uff0c\u5176\u4e2dNA\u8986\u76d6Zr6<\/sub> SBUs\u3001FITC\u548cRITC\u5171\u4ef7\u8fde\u63a5\u81f3BTB-NH2<\/sub>\u914d\u4f53\uff1b<\/p>\n

\uff08b\uff09\u5728NA\u3001FITC\u548c\u548cRITC\u901a\u9053\u4e0e10 mM GSH\u572837\u00b0C\u4e0b\u5b75\u80b215 min\u540e\uff0cNA@Zr-BTB\/F\/R\u7684\u6fc0\u53d1\u5149\u8c31\u548c\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

\uff08c\uff09\u9633\u79bb\u5b50NA@Zr-BTB\/F\/R\u6bd4\u7387\u6cd5\u68c0\u6d4b\u7ebf\u7c92\u4f53\u5931\u8c03\u3001GSH\u6d88\u8017\u548c\u57fa\u8d28\u9178\u5316\u3002<\/p>\n

\u56fe\u4e8c\u3001NA@Zr-BTB\/F\/R\u7684\u8868\u5f81<\/strong>
\n \"\"\uff08a-d\uff09NA@Zr-BTB\/F\/R\u7684TEM\u56fe\u50cf\u3001\u5e26\u6709FFT\u56fe\u6848\u7684HRTEM\u56fe\u50cf\u3001AFM\u5f62\u8c8c\u4ee5\u53caZr-BTB\u7684\u9ad8\u5ea6\u8f6e\u5ed3\uff1b<\/p>\n

\uff08e\uff09\u5bf9\u6bd4Hf6<\/sub>-BTB MOL\u7684\u6a21\u62df\u6a21\u5f0f\uff0c\u65b0\u5236\u5907\u6216\u572837\u00b0C\u4e0b\u4e0e40 mM GSH\u5b75\u80b24 h\u7684Zr-BTB\u548cNA@Zr-BTB\/F\/R\u7684PXRD\u56fe\u8c31\uff1b<\/p>\n

\uff08f\uff09\u4e0e40 mM GSH\u6216HEPES\u5b75\u80b2\u7684NA@Zr-BTB\/F\/R\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u8367\u5149\u54cd\u5e94\u3002<\/p>\n

\u56fe\u4e09\u3001NA@Zr-BTB\/F\/R\u7684\u8367\u5149\u6027\u80fd<\/strong>
\n \"\"\uff08a\uff09\u5728pH=7.4\u4e0b\uff0c\u4e0d\u540cGSH\u6d53\u5ea6\u7684NA@Zr-BTB\/F\/R\u7684NA\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

\uff08b\uff09\u5728\u4e0d\u540c\u7684GSH\u6d53\u5ea6\u4e0b\uff0cNA@Zr-BTB\/F\/R\u7684NA\u3001FITC\u548cRITC\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

\uff08c\uff09NA@Zr-BTB\/F\/R\u5728\u65e0GSH\u7684\u4e0d\u540cpH\u503c\u4e0b\u7684FITC\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

\uff08d\uff09\u5728\u4e0d\u540cpH\u503c\u4e0b\uff0cNA@Zr-BTB\/F\/R\u7684NA\u3001FITC\u548cRITC\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

\uff08e-f\uff09NA@Zr-BTB\/F\/R\u7684NA\u8367\u5149\u4e0eRITC\u8367\u5149\u7684\u6bd4\u7387\u56fe\u548cFITC\u8367\u5149\u4e0eRITC\u8367\u5149\u7684\u6bd4\u7387\u56fe\u3002<\/p>\n

\u56fe\u56db\u3001NA@Zr-BTB\/F\/R\u7684\u9776\u5411\u6027\u80fd<\/strong>
\n \"\"\uff08a-c\uff09\u5728\u5b75\u80b24 h\u540e\uff0cZr-BTB\/R\uff08\u7ea2\u8272\uff09\u5728A2780\u7ec6\u80de\u4e2d\u7684\u4e9a\u7ec6\u80de\u5b9a\u4f4d\uff1b<\/p>\n

\uff08d\uff09\u901a\u8fc7Zr ICP-MS\u6d4b\u91cf\u5728\u7ebf\u7c92\u4f53\u4e2dZr-BTB\/R\u548cNA@Zr-BTB\/F\/R\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u5bcc\u96c6\u3002<\/p>\n

\u56fe\u4e94\u3001NA@Zr-BTB\/F\/R\u7684\u7ec6\u80de\u6210\u50cf<\/strong>
\n \"\"\uff08a\uff09\u5177\u6709NA@Zr-BTB\/F\/R\u7684\u987a\u94c2\u6216HEPES\u5904\u7406\u7684A2780\u548cA2780cis\u7ec6\u80de\u7684\u9ad8\u5206\u8fa8\u7387\u6bd4\u4f8b\u8367\u5149\u6210\u50cf\u4ee3\u8868\u56fe\uff1b<\/p>\n

\uff08b-c\uff09\u5728A2780\u548cA2780cis\u7ec6\u80de\u6709\u65e0\u987a\u94c2\u5b75\u80b2\u540e\uff0cNA@Zr-BTB\/F\/R\u68c0\u6d4b\u5230\u7684\u5177\u6709GSH\u6d88\u8017\u548c\u57fa\u8d28\u9178\u5316\u7684\u7ebf\u7c92\u4f53\u5931\u8c03\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u6784\u5efa\u4e86\u7b2c\u4e00\u4e2a\u7528\u4e8e\u540c\u65f6\u68c0\u6d4bGSH\u548cpH\u7684nMOL\u3002\u7528NA\u53d6\u4ee3Zr6<\/sub> SBUs\u4e0a\u7684FA\u57fa\u56e2\uff0c\u5e76\u4e14\u4f7fFITC\u548cRITC\u4e0eBTB-NH2<\/sub>\u914d\u4f53\u5171\u4ef7\u7edc\u5408NA@Zr-BTB\/F\/R\u4f5c\u4e3a\u7ebf\u7c92\u4f53\u9776\u5411\u7684\u6bd4\u7387\u7eb3\u7c73\u4f20\u611f\u5668\uff0c\u53ef\u4ee5\u72ec\u7acb\u76d1\u6d4b\u6d3b\u7ec6\u80de\u4e2d\u7684GSH\u548cpH\u3002\u901a\u8fc7\u7ec6\u80de\u6210\u50cf\uff0c\u5229\u7528CLSM\u63ed\u793a\u4e86\u7ebf\u7c92\u4f53\u5931\u8c03\u4e0eGSH\u7f3a\u5931\u548c\u57fa\u8d28\u9178\u5316\u7684\u5b9a\u91cf\u8bc1\u636e\u3002\u603b\u4e4b\uff0c\u8be5\u9879\u5de5\u4f5c\u4fc3\u8fdb\u4e86\u57fa\u4e8enMOL\u7684\u6bd4\u7387\u751f\u7269\u4f20\u611f\u5668\u7684\u53d1\u5c55\uff0c\u5c06\u7528\u4e8e\u5176\u4ed6\u751f\u7269\u5206\u6790\u7269\uff0c\u5e76\u4e3a\u7ec6\u80de\u6c34\u5e73\u7684\u75c5\u7406\u751f\u7406\u6761\u4ef6\u63d0\u4f9b\u65b0\u7684\u89c1\u89e3\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aNanoscale Metal-Organic Layers Detect Mitochondrial Dysregulation and Chemoresistance via Ratiometric Sensing of Glutathione and pH<\/a><\/strong>\uff08J. Am. Chem. Soc.<\/em>, 2021<\/strong>, DOI: 10.1021\/jacs.0c11764\uff09<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

\u6797\u6587\u658c\u6559\u6388<\/strong>\u4e8e 1994 \u5e74\u5728\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u5384\u5df4\u7eb3-\u9999\u69df\u5206\u6821\u5316\u5b66\u7cfb\u83b7\u535a\u58eb\u5b66\u4f4d\u30021994 \u81f3 1997 \u5e74\u5728\u7f8e\u56fd\u897f\u5317\u5927\u5b66\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\u30021997 \u5e74\u81f3 2001 \u5e74\u5728\u7f8e\u56fd\u5e03\u5170\u8fea\u65af\u5927\u5b66\u5316\u5b66\u7cfb\u4efb\u52a9\u7406\u6559\u6388\u30022001 \u5e74\u5230 2013 \u5e74\u4efb\u804c\u4e8e\u7f8e\u56fd\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821\uff0c\u5e76\u4e8e 2011 \u5e74\u88ab\u8058\u4e3a Kenan \u6770\u51fa\u6559\u6388\u30022013 \u5e74\u8d77\u62c5\u4efb\u7f8e\u56fd\u829d\u52a0\u54e5\u5927\u5b66\u5316\u5b66\u7cfb James Frank \u6559\u6388\u5e2d\u4f4d\u3002\u7cfb\u4e2d\u56fd\u79d1\u5b66\u9662\u6d77\u5916\u987e\u95ee\u7ec4\u6210\u5458\uff0c\u9999\u6e2f\u7814\u7a76\u8d44\u52a9\u59d4\u5458\u4f1a\u81ea\u7136\u79d1\u5b66\u90e8\u59d4\u5458(2012-2013 \u5e74\u5ea6\u517c\u4efb\u4e3b\u5e2d)\uff0c \u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662 NANO Study Section \u5e38\u52a1\u4f1a\u5458\u30022011 \u5e74\u5165\u9009\u7f8e\u56fd\u79d1\u5b66\u4fc3\u8fdb\u4f1a\u4f1a\u58eb(AAAS fellow)\u3002<\/p>\n

\u6797\u6587\u658c\u6559\u6388\u6240\u9886\u5bfc\u7684\u7814\u7a76\u56e2\u961f\u662f\u56fd\u9645\u4e0a\u6700\u65e9\u8fdb\u884c\u7406\u6027\u8bbe\u8ba1\u5408\u6210\u91d1\u5c5e\uff0d\u6709\u673a\u6846\u67b6\u6750\u6599\u7684\u56e2\u961f\u4e4b\u4e00\uff0c\u4e3b\u8981\u7814\u7a76\u9886\u57df\u4e3a\u529f\u80fd\u6750\u6599\u3001\u624b\u6027\u50ac\u5316\u3001\u5149\u50ac\u5316\u3001\u7eb3\u7c73\u533b\u5b66\u53ca\u5316\u5b66\u836f\u7269\u8bbe\u8ba1\u7b49<\/strong>\u3002\u6797\u6587\u658c\u6559\u6388\u7814\u7a76\u7ec4\u5728 2005 \u5e74\u9996\u6b21\u6210\u529f\u5f00\u53d1\u51fa\u6709\u9ad8\u624b\u6027\u9009\u62e9\u6027\u7684\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u5316\u5408\u7269\u4e0d\u5bf9\u79f0\u50ac\u5316\u5242\uff0c\u540c\u65f6\u5728\u5229\u7528\u91d1\u5c5e\u6709\u673a\u6846\u5316\u5408\u7269\u53d1\u5c55\u975e\u7ebf\u6027\u5149\u5b66\u6750\u6599\u53ca\u4eba\u5de5\u5149\u5408\u4f5c\u7528\u65b9\u9762\u7684\u7814\u7a76\u8d70\u5728\u56fd\u9645\u524d\u5217\uff0c\u6240\u53d1\u5c55\u7684\u5177\u6709\u4e8c\u9636\u975e\u7ebf\u6027\u5149\u5b66\u6027\u8d28\u7684\u91d1\u5c5e\u6709\u673a\u6750\u6599\u662f\u662f\u6700\u65e9\u8fdb\u884c\u6676\u4f53\u5de5\u7a0b\u65b9\u6cd5\u63a7\u5236\u91d1\u5c5e\u6709\u673a\u5316\u5408\u7269\u7684\u5c1d\u8bd5\u4e4b\u4e00\u3002\u8fd1\u5e74\u6765\uff0c\u6797\u6587\u658c\u6559\u6388\u56e2\u961f\u521b\u9020\u6027\u5730\u5f00\u53d1\u4e86\u591a\u79cd\u57fa\u4e8e\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u7eb3\u7c73\u7c92\u5b50\u7684\u751f\u7269\u53ef\u964d\u89e3\u6027\u3001\u9ad8\u836f\u7269\u8f7d\u91cf\u4ee5\u53ca\u5206\u5b50\u53ef\u8c03\u63a7\u6027\u7684\u65b0\u578b\u7eb3\u7c73\u6297\u764c\u836f\u7269\u5e76\u7387\u5148\u62a5\u5bfc\u4e86\u5c40\u90e8\u7eb3\u7c73\u836f\u7269\u9012\u9001\u7528\u4e8e\u5c40\u90e8\u514d\u75ab\u6fc0\u6d3b\u4e0e\u7cfb\u7edf\u6027\u514d\u75ab\u6cbb\u7597\u76f8\u7ed3\u5408\u7684\u764c\u75c7\u6cbb\u7597\u65b0\u601d\u8def\u3002\u4e3a\u4e86\u63a8\u52a8\u76f8\u5173\u4ea7\u54c1\u7684\u4e34\u5e8a\u8f6c\u5316\uff0c\u6797\u6587\u658c\u6559\u6388\u521b\u7acb\u4e86\u540d\u4e3a Coordination Pharmaceuticals \u7684\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u76ee\u524d\u5df2\u6709\u4e09\u79cd\u836f\u7269\u5f00\u59cb\u4e34\u5e8a I \u671f\u7814\u7a76\u3002<\/p>\n

\u6797\u6587\u658c\u6559\u6388\u76ee\u524d\u5df2\u5728\u5305\u62ec Nat. Chem., Nat. Biomed. Eng., Nat. Catal., J. Am. Chem. Soc., Nat. Commun., Chem, Angew. Chem. Int. Ed \u7b49\u4e16\u754c\u9876\u7ea7\u6742\u5fd7\u4e0a\u53d1\u8868\u8fd1 400 \u7bc7\u6587\u7ae0\uff0c\u6587\u7ae0\u88ab\u5f15\u7528\u8d85\u8fc7 56000 \u6b21 (h-index \u2265113)<\/strong> \uff0c\u540c\u65f6\u4ed6\u8fd8\u62c5\u4efb\u591a\u672c\u8457\u540d\u6742\u5fd7\u7684\u987e\u95ee\uff0c\u6bd4\u5982 Chem. Sci., Chem. Mater., ACS Catal, Inorganic Chemistry Frontiers \u548cAsian J. Org. Chem.\u7b49\uff0c\u6797\u6587\u658c\u6559\u6388\u5728\u79d1\u7814\u5de5\u4f5c\u4e2d\u53d6\u5f97\u7684\u5353\u8d8a\u6210\u5c31\uff0c\u4f7f\u5176\u4e8e2009\u5e74\u5165\u9009\u7531\u53d1\u8868\u6587\u7ae0\u5f71\u54cd\u56e0\u5b50\u786e\u5b9a\u76841999-2009\u5e74\u5ea6\u5168\u7403\u201c\u5341\u5927\u5316\u5b66\u5bb6\u201d(\u201cTop ten chemists\u201d\uff0cby Thomson Reuters)\u3002<\/p>\n

\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n

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