{"id":214367,"date":"2020-12-11T06:27:23","date_gmt":"2020-12-10T22:27:23","guid":{"rendered":"\/\/m.iemloyee.com\/?p=214367"},"modified":"2020-12-10T21:15:28","modified_gmt":"2020-12-10T13:15:28","slug":"%e3%80%90%e9%80%9a%e8%ae%af%e4%bd%9c%e8%80%85%e5%b7%b2%e6%a0%a1%e7%a8%bf%e5%9b%9e%e5%a4%8d%e3%80%91%e5%8c%97%e7%90%86%e5%b7%a5acc-chem-res-%e7%bb%bc%e8%bf%b0%ef%bc%9a%e5%8a%9f%e8%83%bd%e5%8c%96","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=214367","title":{"rendered":"\u5317\u7406\u5de5Acc. Chem. Res.\u7efc\u8ff0\uff1a\u529f\u80fd\u5316\u5f02\u8148\u57fa\u805a\u5408\u7269"},"content":{"rendered":"<p><strong>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n<p>\u57fa\u4e8e\u5f02\u8148\u7684\u53cd\u5e94\u7684\u7814\u7a76\u6700\u65e9\u53ef\u4ee5\u8ffd\u6eaf\u5230\u4e0a\u4e16\u7eaa\u4e8c\u5341\u5e74\u4ee3\uff0c\u4f46\u76f4\u5230\u76ee\u524d\u7684\u57fa\u4e8e\u5f02\u8148\u53cd\u5e94\u6784\u7b51\u7684\u805a\u5408\u7269\uff08IBPs\uff09\u5374\u5341\u5206\u7a00\u7f3a\u3002\u8fd9\u5176\u4e2d\u4e3b\u8981\u7684\u539f\u56e0\u662f\u7f3a\u4e4f\u9ad8\u6548\u7684\u805a\u5408\u65b9\u6cd5\uff0c\u9650\u5236\u4e86IBPs\u7684\u5927\u89c4\u6a21\u5236\u5907\u548c\u5e94\u7528\u3002\u867d\u7136\u57fa\u4e8e\u73b0\u4ee3\u6709\u673a\u5316\u5b66\u80fd\u591f\u5f00\u53d1\u529f\u80fd\u5316IBPs\uff0c\u4f46\u5229\u7528\u5c0f\u5206\u5b50\u5f02\u8148\u53cd\u5e94\u5236\u5907IBPs\u4f9d\u7136\u9762\u4e34\u6311\u6218\u3002\u800c\u5bf9\u4e8e\u65b0\u578b\u50ac\u5316\u5242\u548c\u805a\u5408\u65b9\u6cd5\u7684\u51fa\u73b0\uff0c\u8fd1\u5e74\u6765\u8d8a\u6765\u8d8a\u591a\u7684IBPs\u88ab\u6210\u529f\u5408\u6210\u51fa\u6765\u3002\u8fd9\u5176\u4e2d\uff0c\u4e3b\u8981\u6709\u4e24\u79cd\u5f02\u8148\u5355\u4f53\u53ef\u88ab\u7528\u4e8e\u6784\u5efaIBPs\uff0c\u5206\u522b\u662f\u53ef\u5728\u7ebf\u6027\u805a\u5408\u7269\u94fe\u4e0a\u5f15\u5165\u529f\u80fd\u5316\u4fa7\u57fa\u7684\u5355\u5f02\u8148\u5355\u4f53\u548c\u53ef\u7528\u4e8e\u6784\u5efa\u6742\u73af\u3001\u87ba\u73af\u805a\u5408\u7269\u7684\u53cc\u5f02\u8148\u5355\u4f53\u3002\u901a\u8fc7\u5408\u7406\u7684\u7ed3\u6784\u8bbe\u8ba1\u5b9e\u73b0\u5177\u6709\u529f\u80fd\u7684\u805a\u5408\u7269\uff0c\u53ef\u4e3aIBPs\u7684\u53d1\u5c55\u5f00\u8f9f\u9053\u8def\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u671f\uff0c<strong>\u5317\u4eac\u7406\u5de5\u5927\u5b66\u7684\u8521\u653f\u65ed\u548c\u8463\u5b87\u5e73<\/strong>\u7b49\u4eba\u53d1\u8868\u4e86\u6709\u5173\u529f\u80fd\u5316\u5f02\u8148\u57fa\u805a\u5408\u7269\u7684\u7efc\u8ff0\u6587\u7ae0\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u9996\u5148\u4ecb\u7ecd\u4e86\u5728\u5f02\u8148\u5355\u4f53\u8bbe\u8ba1\u53ca\u5176\u76f8\u5173\u9886\u57df\u7684\u7814\u7a76\u8fdb\u5c55\u548c\u672c\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u6210\u679c\u3002\u968f\u540e\uff0c\u901a\u8fc7\u9009\u53d6\u5178\u578b\u6848\u4f8b\uff0c\u63a2\u8ba8\u4e86\u529f\u80fd\u5316\u805a\u5408\u7269\u7684\u7279\u5f81\u6027\u80fd\u548c\u6f5c\u5728\u5e94\u7528\u3002\u7279\u522b\u662f\u5728\u5149\u5b66\u9886\u57df\uff0c\u53d1\u73b0\u7d2b\u5916\u5149\u654f\u611f\u7684IBPs\u5728\u5149\u523b\u6280\u672f\u65b9\u9762\u5177\u6709\u5e94\u7528\u524d\u666f\u3002\u800c\u4e00\u9505\u6cd5\u9ad8\u6548\u5b9e\u73b0\u53cc\u5f02\u8148\u548c\u4e8c\u6c27\u5316\u78b3\u7684\u805a\u5408\u5219\u4e3a\u4e8c\u6c27\u5316\u78b3\u7684\u518d\u5229\u7528\uff0c\u4e3a\u7f13\u89e3\u6e29\u5ba4\u6548\u5e94\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u7ed3\u6784\u6539\u6027\uff0c\u542b\u6709\u4e8c\u7532\u82ef\u7684IBPs\u80fd\u591f\u8868\u73b0\u51fa\u9ed1\u8272\u6750\u6599\u7684\u7279\u70b9\uff0c\u53ef\u7528\u4e8e\u5236\u9020\u70ed\u7535\u4f20\u611f\u5668\u3001\u70ed\u63a2\u6d4b\u5668\u7b49\u3002\u5728\u6700\u8fd1\u7684\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u6240\u5728\u7684\u8bfe\u9898\u7ec4\u8fd8\u5408\u6210\u4e86\u5177\u6709\u7c07\u53d1\u5149\u6027\u80fd\u7684\u87ba\u6742\u73afIBP\uff0c\u53ef\u7279\u5f02\u6027\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u8bc6\u522b\u548c\u6740\u4f24\u3002\u901a\u8fc7\u603b\u7ed3\u8fd9\u4e9b\u6700\u65b0\u7814\u7a76\u6210\u679c\uff0c\u4e3a\u57fa\u4e8e\u5f02\u8148\u5316\u5b66\u7684\u805a\u5408\u65b9\u6cd5\u80fd\u591f\u4e3a\u5b9e\u73b0\u591a\u6837\u529f\u80fd\u5316\u5927\u5206\u5b50\u53ca\u5176\u6750\u6599\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201cFunctional Isocyanide-Based Polymers\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u7efc\u8ff0\u671f\u520a<strong>Acc. Chem. Res.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u5f02\u8148\u5316\u5b66<\/strong><\/p>\n<p>\u4f5c\u8005\u9996\u5148\u4ecb\u7ecd\u4e86\u5f02\u8148\u5355\u4f53\u5728\u5408\u6210\u5316\u5b66\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u7531\u4e8e\u5f02\u6c30\u57fa\u56e2\u7684\u9ad8\u53cd\u5e94\u6027\u8d4b\u4e88\u4e86\u5f02\u6c30\u5316\u7269\u6709\u80fd\u529b\u53c2\u4e0e\u591a\u79cd\u7c7b\u578b\u7684\u5206\u5b50\u53cd\u5e94\uff0c\u5305\u62ec\u03b1-\u52a0\u6210\uff0c\u914d\u4f4d\u548c\u81ea\u7531\u57fa\u53cd\u5e94\u7b49\uff0c\u6210\u529f\u6784\u5efa\u4e86\u4e00\u7cfb\u5217\u5c0f\u5206\u5b50\u529f\u80fd\u6027\u5316\u5408\u7269\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214370\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/s1.jpg\" alt=\"\" width=\"560\" height=\"537\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/s1.jpg 560w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/s1-300x288.jpg 300w\" sizes=\"(max-width: 560px) 100vw, 560px\" \/><\/p>\n<p>\u56fe1. \u5f02\u8148\u53c2\u4e0e\u7684\u5316\u5b66\u53cd\u5e94<\/p>\n<p><strong>\u57fa\u4e8e\u5355\u5f02\u6c30\u5316\u7269\u5355\u4f53\u7684\u805a\u5408<\/strong><\/p>\n<p>\u57fa\u4e8e\u5c0f\u5206\u5b50\u5f02\u8148\u7684\u9ad8\u53cd\u5e94\u6027\uff0c\u5c06\u5f02\u8148\u5355\u4f53\u5f15\u5165\u5230\u805a\u5408\u53cd\u5e94\u4e2d\u3002\u901a\u8fc7\u5bf9\u50ac\u5316\u5242\u7684\u4e0d\u65ad\u4f18\u5316\uff0c\u5b9e\u73b0\u4ece\u91d1\u5c5e\u50ac\u5316\u5230\u65e0\u91d1\u5c5e\u50ac\u5316\uff0c\u901a\u8fc7\u81ea\u805a\u6784\u5efa\u529f\u80fd\u6027\u87ba\u65cb\u72b6\u805a\u5408\u7269\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214369\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/s2.jpeg\" alt=\"\" width=\"600\" height=\"451\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/s2.jpeg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/s2-300x226.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe2. \u805a\u5408\u7269<strong>P1-P6<\/strong>\uff0c\u5171\u805a\u7269<strong>PX<\/strong>\u7684\u5408\u6210\u7b56\u7565\u548c\u5206\u5b50\u7ed3\u6784<\/p>\n<p><strong>\u57fa\u4e8e\u53cc\u5f02\u8148\u5355\u4f53\u7684\u591a\u7ec4\u5206\u805a\u5408<\/strong><\/p>\n<p>\u901a\u8fc7\u65e0\u91d1\u5c5e\u50ac\u5316\u4e00\u9505\u6cd5\u5b9e\u73b0\u591a\u7ec4\u5206\u805a\u5408\uff0c\u5c06\u53cc\u5f02\u8148\u4e0e\u5185\u7094\u916f\u5f62\u6210\u7684\u6d3b\u6027\u79bb\u5b50\u4e2d\u95f4\u4f53\u4e0e\u4e0d\u540c\u7684\u7b2c\u4e09\u7ec4\u5206\u53cd\u5e94\uff0c\u6210\u529f\u6784\u5efa\u4e86\u6742\u73af\u548c\u87ba\u73af\u805a\u5408\u7269\u3002\u8fd9\u79cd\u901a\u8fc7\u975e\u73af\u5316\u5408\u7269\u6784\u5efa\u73af\u5316\u805a\u5408\u7269\u5177\u6709\u9ad8\u539f\u5b50\u5229\u7528\u7387\uff0c\u5176\u4e2d\u591a\u7ec4\u5206\u87ba\u5316\u805a\u5408\u662f\u8be5\u56e2\u961f\u9996\u6b21\u63d0\u51fa\u5e76\u7ee7\u7eed\u53d1\u5c55\u7684\u65b0\u8bfe\u9898\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214368\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/s3.jpeg\" alt=\"\" width=\"600\" height=\"472\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/s3.jpeg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/s3-300x236.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe3.\u57fa\u4e8e\u53cc\u5f02\u8148\u5355\u4f53\u591a\u7ec4\u5206\u805a\u5408<\/p>\n<p>\u57fa\u4e8e\u53cc\u5f02\u8148\u4e0e\u5185\u7094\u916f\uff0c\u53cc\u919b\u7684\u53cd\u5e94(a)\u3002\u901a\u8fc7\u5bf9\u4e09\u4e2a\u5355\u4f53\u7684\u5e95\u7269\u62d3\u5c55\uff0c\u6784\u5efa\u4e86\u591a\u79cd\u544b\u5583\u805a\u5408\u7269\u3002\u57fa\u4e8e\u53cc\u919b\u7684\u7ed3\u6784\uff0c\u4f5c\u8005\u53c8\u5c06\u6d3b\u5316\u53cc\u916e\u4f5c\u4e3a\u7b2c\u4e09\u7ec4\u5206\uff0c\u6210\u529f\u5f97\u5230\u5f02\u544b\u5583\u805a\u5408\u7269\u3002\u901a\u8fc7\u5bf9\u5e95\u7269\u7684\u62d3\u5c55\uff0c\u6784\u5efa\u4e86\u591a\u79cd\u53d6\u4ee3\u57fa\u5f02\u544b\u5583\u805a\u5408\u7269\u3002\u63d0\u51fa\u4e86\u4e00\u7c7b\u65b0\u578b\u7684\u591a\u7ec4\u5206\u805a\u5408\u53cd\u5e94-\u591a\u7ec4\u5206\u87ba\u5316\u805a\u5408 (multicomponent spiropolymerization\uff0cMCS)\u3002\u5c06\u591a\u7ec4\u5206\u7684\u975e\u87ba\u73af\u5355\u4f53\u901a\u8fc7\u4e00\u6b65\u53cd\u5e94\uff0c\u5f97\u5230\u542b\u87ba\u73af\u7ed3\u6784\u805a\u5408\u7269\u7684\u53cd\u5e94\u5b9a\u4e49\u4e3a\u591a\u7ec4\u5206\u87ba\u5316\u805a\u5408\u3002\u4f5c\u8005\u5c06CO<sub>2<\/sub>\u4f5c\u4e3a\u7b2c\u4e09\u7ec4\u5206\u5f15\u5165\u805a\u5408\u5b9e\u73b0\u87ba\u73af\u805a\u5408\u7269\u7684\u6784\u5efa\u3002\u57fa\u4e8e\u4e0a\u8ff0\u87ba\u73af\u805a\u5408\u7269\u7684\u5de5\u4f5c\uff0c\u8fdb\u4e00\u6b65\u5c06\u82ef\u7532\u9170\u57fa\u5f02\u786b\u6c30\u9178\u916f\u4f5c\u4e3a\u7b2c\u4e09\u7ec4\u5206\u5f15\u5165\u87ba\u73af\u805a\u5408\u4e2d<\/p>\n<p><strong>\u6298\u5c04\u7387<\/strong><\/p>\n<p>\u6298\u5c04\u7387\u4f5c\u4e3a\u805a\u5408\u7269\u6750\u6599\u7684\u4e00\u4e2a\u91cd\u8981\u7269\u7406\u6027\u8d28\u3002\u800c\u5bf9\u805a\u544b\u5583\u80fa(P7m)\uff0c\u5728632.8 nm\u5904\u7684RI\u503c\u4e3an = 1.680\uff0c\u8fdc\u9ad8\u4e8e\u5546\u7528\u5149\u5b66\u805a\u5408\u7269\u6750\u6599\uff0c\u4e3a\u540e\u7eed\u8fd9\u7c7b\u805a\u5408\u7269\u5149\u5b66\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u4e2a\u66f4\u597d\u7684\u53d1\u5c55\u3002<\/p>\n<p><strong>\u9ed1\u6750\u6599\u6027\u8d28<\/strong><\/p>\n<p>\u9ed1\u6750\u6599\u56e0\u5176\u5177\u6709\u9ad8\u7684\u5438\u6536\u5149\u7684\u6027\u8d28\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u5728\u70ed\u91ca\u7535\u4f20\u611f\u5668\uff0c\u70ed\u63a2\u6d4b\u5668\uff0c\u5149\u5b66\u4eea\u5668\u7b49\u3002\u4e0e\u5c0f\u5206\u5b50\u9ed1\u8272\u6750\u6599\u76f8\u6bd4\uff0c\u805a\u5408\u7269\u9ed1\u8272\u6750\u6599\u5177\u6709\u66f4\u597d\u7684\u52a0\u5de5\u6027\u80fd\u3002\u805a\u5408\u7269P7e, P7f\u663e\u793a\u51fa\u9ed1\u8272\u5916\u89c2\u3002\u5bf9\u4e8e\u6240\u6709\u8584\u819c\uff0c\u8be5\u805a\u5408\u7269\u7684\u900f\u5c04\u7387\u4ece700 nm\u5230200 nm\u9010\u6e10\u964d\u4f4e\uff0c\u8868\u660e\u805a\u5408\u7269\u5728\u53ef\u89c1\u5149\u533a\u57df(200-700nm)\u5177\u6709\u8f83\u4f4e\u7684\u900f\u5c04\u7387\uff0c\u5177\u6709\u9ed1\u6750\u6599\u7684\u6027\u8d28\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214373\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/f3.jpg\" alt=\"\" width=\"600\" height=\"256\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/f3.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/f3-300x128.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe4. (a) <strong>P7f<\/strong>\u7684\u900f\u5c04\u5149\u8c31\uff1b(b) <strong>P7a <\/strong>(CCDC-1854434) \u7ed3\u6784\u5355\u5143\u7684\u6676\u4f53\u7ed3\u6784<\/p>\n<p><strong>\u65cb\u5149\u6027<\/strong><\/p>\n<p>\u901a\u8fc7\u5355\u5f02\u8148\u4e0e\u624b\u6027\u57fa\u56e2\u805a\u5408\u6784\u5efa\u4e86\u87ba\u65cb\u6784\u8c61\u805a\u5408\u7269\uff0c\u8868\u73b0\u51fa\u826f\u597d\u7684\u5149\u5b66\u6027\u8d28\u3002a\u663e\u793a\u4e86\u5206\u522b\u542b\u6709M4\u548cM5\u5355\u5143\u7684\u4e00\u5bf9\u805a\u5408\u7269\u7684\u5706\u4e8c\u8272\u6027(CD)\u5149\u8c31\u3002\u5728364 nm\u5904\u89c2\u5bdf\u5230\u4e00\u81f4\u7684\u6b63\u8d1f\u6548\u5e94\uff0c\u663e\u793aP5c\u548cP4c\u76f8\u53cd\u7684\u5355\u624b\u87ba\u65cb\u3002\u4f5c\u8005\u540c\u6837\u8fd8\u663e\u793a\u4e86\u975e\u624b\u6027M3\u4e0e\u624b\u6027M4\u6216M5\u5728\u4e0d\u540cM4\/M5\/M3\u6469\u5c14\u6bd4\u4e0b\u7684\u87ba\u65cb\u9009\u62e9\u6027\u65e0\u89c4\u5171\u805a\uff0c\u4ea7\u751f\u4e86\u4e00\u7cfb\u5217\u4e0d\u540c\u7a0b\u5ea6\u7684\u5355\u624b\u87ba\u65cb\u6784\u8c61\u7684P5Xc\u548cP6Xc\u805a\u5408\u7269\u3002\u968f\u7740\u624b\u6027\u5355\u4f53\u6bd4\u4f8b\u7684\u589e\u52a0\uff0cCD\u5149\u8c31\u4e2d\u89c2\u5bdf\u5230\u7684\u5355\u624b\u6027\u87ba\u65cb\u6784\u8c61\u7684\u7a0b\u5ea6\u4e5f\u76f8\u5e94\u589e\u52a0\uff0c\u8bf4\u660e\u5171\u805a\u7269\u4e2d\u7684M4\/M5\u5e8f\u5217\u53ef\u4ee5\u8bf1\u5bfc\u975e\u624b\u6027M3\u7684\u87ba\u65cb\u6784\u8c61\u751f\u6210\u5149\u5b66\u6d3b\u6027\u5171\u805a\u7269\u3002<\/p>\n<p><strong>\u751f\u7269\u5b66\u63a2\u9488<\/strong><\/p>\n<p>\u87ba\u73af\u7ed3\u6784\u548c\u6742\u539f\u5b50\u7ec4\u6210\u7684\u87ba\u73af\u4f53\u805a\u5408\u7269\u5177\u6709\u8f83\u9ad8\u7684\u751f\u7269\u6d3b\u6027\u4ee5\u53ca\u70ed\u7a33\u5b9a\u6027\u548c\u5316\u5b66\u7a33\u5b9a\u6027\uff0c\u53ef\u4f5c\u4e3a\u836f\u7269\u8f7d\u4f53\u548c\u86cb\u767d\u8d28\u6291\u5236\u5242\u7684\u529f\u80fd\u6750\u6599\u3002\u53d1\u73b0\u5177\u6709CTE\u6027\u8d28\u7684P11\u805a\u5408\u7269\u53ef\u4ee5\u7528\u4f5cp53-MDM2\u6291\u5236\u5242\u4ee5\u53ca\u7528\u4e8e\u764c\u7ec6\u80de\u9776\u6210\u50cf\u3002\u4f53\u5916\u5b9e\u9a8c\u548c\u5206\u5b50\u5bf9\u63a5\u5747\u8868\u660eMDM2\u4e0eP11\u5b58\u5728\u7a33\u5b9a\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u5bfc\u81f4P11\u7684\u8367\u5149\u589e\u5f3a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214372\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/f6.jpg\" alt=\"\" width=\"600\" height=\"240\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/f6.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/f6-300x120.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe5. (a) \u7528\u4e0d\u540c\u6d53\u5ea6\u7684MDM2\u5904\u7406\u7684<strong>P11<\/strong>\u7684\u76f8\u5bf9\u8367\u5149\u5f3a\u5ea6\uff1b(b) <strong>P11<\/strong>(\u4e09\u805a\u7269)\u548cMDM2\u86cb\u767d\u7684\u5bf9\u63a5\u7814\u7a76<\/p>\n<p>\u7531\u4e8eMDM2\u5728\u764c\u7ec6\u80de\u4e2d\u8fc7\u8868\u8fbe\uff0cP11\u4e0eMDM2\u7684\u76f8\u4e92\u4f5c\u7528\u53ef\u4f5c\u4e3a\u764c\u7ec6\u80de\u793a\u8e2a\u5242\u6765\u533a\u5206\u764c\u7ec6\u80de\u4e0e\u6b63\u5e38\u7ec6\u80de\u3002\u6240\u6709\u7528P11\u5b75\u80b2\u7684\u764c\u7ec6\u80de\u90fd\u8868\u73b0\u51fa\u660e\u4eae\u7684\u8367\u5149\uff0c\u800c\u975e\u764c\u7ec6\u80de\u53ea\u8868\u73b0\u51fa\u5fae\u5f31\u7684\u8367\u5149\u3002\u8fd8\u53d1\u73b0\u8be5\u805a\u5408\u7269P11\u4e0eMDM2\u76f8\u4e92\u4f5c\u7528\u53ef\u4f7fp53\u91cd\u65b0\u6fc0\u6d3b\uff0c\u5728\u764c\u7ec6\u80de\u4e2d\u4ea7\u751fROS\uff0c\u6700\u7ec8\u5bfc\u81f4\u764c\u7ec6\u80de\u51cb\u4ea1\uff0c\u4f46\u5bf9\u975e\u764c\u7ec6\u80de\u6ca1\u6709\u660e\u663e\u7684\u7ec6\u80de\u6bd2\u6027\u3002\u56e0\u6b64\uff0c\u87ba\u73af\u805a\u5408\u7269\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u764c\u75c7\u836f\u7269\u652f\u67b6\u5177\u6709\u5de8\u5927\u7684\u6f5c\u529b\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-214371\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/f7.jpg\" alt=\"\" width=\"600\" height=\"235\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/f7.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/12\/f7-300x118.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe6. \u4e0d\u540c\u7ec6\u80de\u7cfb\u7684\u5171\u805a\u7126\u6fc0\u5149\u626b\u63cf\u663e\u5fae\u56fe\u50cf (a-g) \u80bf\u7624\u7ec6\u80de\uff1b(h-j)\u6b63\u5e38\u7ec6\u80de<\/p>\n<p><strong>\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n<p>\u5177\u6709\u660e\u786e\u7ed3\u6784\u3001\u72ec\u7279\u6027\u80fd\u7684\u65b0\u578bIBPs\u7684\u8bbe\u8ba1\u548c\u5408\u6210\u662f\u4e00\u9879\u9700\u8981\u5bf9\u5408\u6210\u65b9\u6cd5\u548c\u529f\u80fd\u57fa\u56e2\u5f15\u5165\u8fdb\u884c\u534f\u540c\u601d\u8003\u7684\u6311\u6218\u3002\u76ee\u524d\uff0c\u4e3a\u4e86\u53d1\u5c55IBPs\uff0c\u7814\u7a76\u4eba\u5458\u4ecd\u7136\u9700\u8981\u63a2\u7d22\u65b0\u578b\u50ac\u5316\u5242\u548c\u5408\u6210\u65b9\u6cd5\u3002\u4f8b\u5982\uff0c\u5bf9\u4e8e\u5355\u5f02\u8148\u57fa\u805a\u5408\u6765\u8bf4\uff0c\u5355\u4f53\u7684\u83b7\u5f97\u66f4\u52a0\u5bb9\u6613\uff0c\u7136\u800c\u6bd2\u6027\u5927\u3001\u4e0d\u7a33\u5b9a\u7684\u5355\u5f02\u8148\u5374\u4e5f\u963b\u788d\u7740\u805a\u5408\u7269\u7684\u89c4\u6a21\u5316\u5de5\u4e1a\u5236\u5907\u3002\u6b64\u5916\uff0c\u5efa\u7acb\u660e\u786e\u7684\u7ed3\u6784-\u529f\u80fd\u5173\u7cfb\u5e76\u8fdb\u4e00\u6b65\u62d3\u5c55\u5e94\u7528\u8303\u56f4\uff0c\u4e5f\u662fIBPs\u5982\u4eca\u9762\u4e34\u7684\u91cd\u8981\u95ee\u9898\u3002\u4f5c\u8005\u6240\u5728\u7684\u8bfe\u9898\u7ec4\u4e5f\u4f1a\u5728\u672a\u6765\u7684\u7814\u7a76\u4e2d\u7ee7\u7eed\u81f4\u529b\u4e8e\u5408\u6210\u529f\u80fd\u5316IBPs\uff0c\u5e76\u4e14\u57fa\u4e8e\u6b64\u7c7b\u805a\u5408\u7269\u5f00\u53d1\u62d3\u5c55\u66f4\u591a\u7279\u5b9a\u5e94\u7528\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.accounts.0c00514\" target=\"_blank\" rel=\"noopener\">Functional Isocyanide-Based Polymers<\/a>. <em>Acc. Chem. Res.<\/em>, <strong>2020<\/strong>, DOI: 10.1021\/acs.accounts.0c00514<\/p>\n<p><strong>\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb\uff1a<\/strong><\/p>\n<p>\u8521\u653f\u65ed\uff0c2005\u5e74\u81f32009\u5e74\u5c31\u8bfb\u4e8e\u6b66\u6c49\u5927\u5b66\u5316\u5b66\u4e13\u4e1a\u30022014\u5e74\u5728\u4e2d\u79d1\u9662\u5316\u5b66\u7814\u7a76\u6240\u83b7\u5f97\u6709\u673a\u5316\u5b66\u535a\u58eb\u5b66\u4f4d\u3002\u4e4b\u540e\uff0c\u4ed6\u5728\u829d\u52a0\u54e5\u5927\u5b66\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\u3002\u4ed6\u73b0\u5728\u662f\u5317\u4eac\u7406\u5de5\u5927\u5b66\u7684\u526f\u6559\u6388\u3002\u76ee\u524d\u4e3b\u8981\u4ece\u4e8b\u7eaf\u6709\u673a\u5ba4\u6e29\u78f7\u5149\u6750\u6599\u5f00\u53d1\u53ca\u529f\u80fd\u805a\u5408\u7269\u7684\u5408\u6210\u548c\u5e94\u7528\u3002<\/p>\n<p>\u8463\u5b87\u5e73\uff0c1986\u5e74\u5728\u5409\u6797\u5927\u5b66\u83b7\u5f97\u5316\u5b66\u5b66\u58eb\u5b66\u4f4d\uff0c1992\u5e74\u5728\u6d59\u6c5f\u5927\u5b66\u83b7\u5f97\u9ad8\u5206\u5b50\u79d1\u5b66\u535a\u58eb\u5b66\u4f4d\u30021992\u5e74\u81f31994\u5e74\u5728\u5317\u4eac\u5927\u5b66\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\u3002\u4ed6\u4ece1994\u5e74\u8d77\u62c5\u4efb\u5317\u4eac\u7406\u5de5\u5927\u5b66\u526f\u6559\u6388\uff0c\u4ece2001\u5e74\u8d77\u62c5\u4efb\u6559\u6388\u3002\u76ee\u524d\u4e3b\u8981\u4ece\u4e8b\u4e09\u952e\u805a\u5408\u7269\u7684\u5408\u6210\u53ca\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\u6750\u6599\u5f00\u53d1\u548c\u5e94\u7528\u30022017\u5e74\u83b7\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u4e00\u7b49\u5956\u3002<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u57fa\u4e8e\u5f02\u8148\u7684\u53cd\u5e94\u7684\u7814\u7a76\u6700\u65e9\u53ef\u4ee5\u8ffd\u6eaf\u5230\u4e0a\u4e16\u7eaa\u4e8c\u5341\u5e74\u4ee3\uff0c\u4f46\u76f4\u5230\u76ee\u524d\u7684\u57fa\u4e8e\u5f02\u8148\u53cd\u5e94\u6784\u7b51\u7684\u805a\u5408\u7269\uff08IBPs\uff09\u5374\u5341\u5206\u7a00\u7f3a\u3002\u8fd9\u5176\u4e2d\u4e3b\u8981\u7684\u539f\u56e0\u662f\u7f3a\u4e4f\u9ad8\u6548\u7684\u805a\u5408\u65b9\u6cd5&#8230;<\/p>\n","protected":false},"author":1076,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-214367","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/214367"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1076"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=214367"}],"version-history":[{"count":3,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/214367\/revisions"}],"predecessor-version":[{"id":214379,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/214367\/revisions\/214379"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=214367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=214367"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=214367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}