{"id":210202,"date":"2020-09-28T06:30:18","date_gmt":"2020-09-27T22:30:18","guid":{"rendered":"\/\/m.iemloyee.com\/?p=210202"},"modified":"2020-09-27T21:11:23","modified_gmt":"2020-09-27T13:11:23","slug":"%e3%80%90%e6%8a%95%e7%a8%bf%e3%80%91%e8%a5%bf%e5%8d%97%e6%b0%91%e6%97%8f%e5%a4%a7%e5%ad%a6theranostics%ef%bc%9a%e5%a4%9a%e9%87%91%e5%b1%9e%e6%b0%a7%e9%85%b8%e7%9b%90polyoxometallates%e7%9a%84","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=210202","title":{"rendered":"\u897f\u5357\u6c11\u65cf\u5927\u5b66Theranostics\uff1a\u591a\u91d1\u5c5e\u6c27\u9178\u76d0(Polyoxometallates)\u7684\u751f\u7269\u819c\u5fae\u73af\u5883\u8c03\u63a7\u4e0e\u5149\u70ed\u589e\u5f3a\u9ad8\u6548\u6297\u83cc"},"content":{"rendered":"

\u76ee\u524d\uff0c\u7531\u4e8e\u6ee5\u7528\u6297\u751f\u7d20\u800c\u4ea7\u751f\u7684\u751f\u7269\u819c\u5bf9\u5168\u7403\u516c\u5171\u536b\u751f\u9020\u6210\u4e25\u91cd\u5a01\u80c1\u3002\u8fd9\u7c7b\u8584\u819c\u662f\u5bfc\u81f4\u6297\u83cc\u6cbb\u7597\u5931\u8d25\u7684\u4e3b\u8981\u56e0\u7d20\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u65b0\u578b\u6297\u83cc\u5242\u6216\u7b56\u7565\u8feb\u5728\u7709\u776b\u3002<\/p>\n

\u591a\u91d1\u5c5e\u6c27\u9178\u76d0(Polyoxometallates, POMs)\u662f\u4e00\u7c7b\u5178\u578b\u7684\u65e0\u673a\u7eb3\u7c73\u56e2\u7c07\uff0c\u4e3b\u8981\u7531\u8fc7\u6e21\u91d1\u5c5e\u6216\u7a00\u571f\u5143\u7d20\u4e0e\u6c27\u914d\u4f53\u901a\u8fc7\u6865\u6c27\u952e\u94fe\u63a5\u800c\u6210\u3002\u7531\u4e8e\u5176\u5177\u6709\u72ec\u7279\u7684\u7535\u5b66\u7ed3\u6784\u548c\u4f18\u8d8a\u7684\u7406\u5316\u6027\u80fd\uff0c\u53ef\u4f5c\u4e3a\u7c7b\u8fc7\u6c27\u5316\u7269\u9176\u50ac\u5316\u76f8\u5e94\u5e95\u7269\u4ea7\u751f\u6d3b\u6027\u6c27(ROS)\uff0c\u800c\u4e14\u5728\u7ec6\u83cc\u751f\u7269\u819c\u5fae\u9178\u548c\u8fd8\u539f\u6027\u6761\u4ef6\u4e0b\uff0cPOMs\u53ef\u81ea\u7ec4\u88c5\u4ea7\u751f\u5927\u7684\u805a\u96c6\u4f53\uff0c\u540c\u65f6\u589e\u5f3a\u8fd1\u7ea2\u5916\u5149\u5438\u6536\uff0c\u63d0\u9ad8\u5176\u5149\u70ed\u8f6c\u6362\u6548\u5e94\uff0c\u4ece\u800c\u5728\u6297\u83cc\u9886\u57df\u5c55\u73b0\u51fa\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002\u4f46\u662f\uff0c\u5355\u4e00\u7684\u7c7b\u8fc7\u6c27\u5316\u9176\u53cd\u5e94\u6d3b\u6027\u6216\u5149\u70ed\u6cbb\u7597\u6548\u5e94\u6709\u9650\uff0c\u751f\u6210\u7684ROS\u5f80\u5f80\u96be\u4ee5\u9ad8\u6548\u4f5c\u7528\u4e8e\u7ec6\u83cc\uff0c\u4ece\u800c\u5f71\u54cd\u5176\u6297\u83cc\u6d3b\u6027\u3002\u56e0\u6b64\uff0c\u5c06\u7c7b\u9176\u50ac\u5316\u6d3b\u6027\u548c\u5149\u70ed\u589e\u5f3a\u50ac\u5316\u6548\u5e94\u7684\u6709\u673a\u7ed3\u5408\u662f\u5b9e\u73b0\u591a\u91d1\u5c5e\u6c27\u9178\u76d0\u9ad8\u6548\u6297\u83cc\u7684\u5173\u952e\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u897f\u5357\u6c11\u65cf\u5927\u5b66\u5316\u5b66\u4e0e\u73af\u5883\u5b66\u9662\u96cd\u5a9b\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u5177\u6709\u4f18\u5f02\u751f\u7269\u819c\u5fae\u73af\u5883\u8c03\u63a7\u7684\u65b0\u578b\u94a8\u57fa\u591a\u91d1\u5c5e\u6c27\u9178\u76d0\u7eb3\u7c73\u56e2\u7c07(GdW10<\/sub>O36<\/sub>\u00a0NCs)\u3002\u5728\u5916\u754c808 nm\u8fd1\u7ea2\u5916\u6fc0\u5149\u7684\u7167\u5c04\u4e0b\uff0cGdW10<\/sub>O36<\/sub>\u00a0NCs\u88ab\u8fd8\u539f\u6240\u5f62\u6210\u7684\u8fd8\u539f\u578b\u591a\u91d1\u5c5e\u6c27\u9178\u76d0\u7eb3\u7c73\u56e2\u7c07(reduced GdW10<\/sub>O36<\/sub>\u00a0NCs)\u8868\u73b0\u51fa\u5f3a\u7684\u8fd1\u7ea2\u5916\u7ebf\u5438\u6536\u548c\u9ad8\u7684\u5149\u70ed\u8f6c\u5316\u6548\u5e94\uff0c\u4e14\u8868\u73b0\u51fa\u6750\u6599\u5c3a\u5bf8\uff0c\u6d53\u5ea6\u548c\u6fc0\u5149\u529f\u7387\u5bc6\u5ea6\u591a\u91cd\u4f9d\u8d56\u6027\u3002\u5e76\u4e14\uff0c\u5728\u8054\u5408\u5916\u754c808 nm\u8fd1\u7ea2\u5916\u6fc0\u5149\u548c\u4f53\u5185\u6781\u4f4e\u6d53\u5ea6\u7684\u8fc7\u6c27\u5316\u6c22(H2<\/sub>O2<\/sub>, 100 \u03bcM)\u7684\u60c5\u51b5\u4e0b\uff0c\u4f4e\u6d53\u5ea6\u7684reduced GdW10<\/sub>O36<\/sub>\u00a0NCs (100\u03bcg\/Ml)\u5bf9\u9769\u5170\u6c0f\u9634\u6027\u83cc\uff08\u5927\u80a0\u6746\u83cc\uff09\u548c\u9769\u5170\u6c0f\u9633\u6027\u83cc\uff08\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\uff09\u7684\u6291\u83cc\u6548\u7387\u5747\u53ef\u8fbe85 %\u4ee5\u4e0a\u3002\u901a\u8fc7\u6297\u83cc\u673a\u7406\u7684\u7814\u7a76\u53d1\u73b0\uff0creduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u4e0d\u4ec5\u80fd\u591f\u901a\u8fc7\u5176\u7c7b\u8fc7\u6c27\u5316\u7269\u9176\u7684\u50ac\u5316\u6027\u8d28\uff0c\u4fc3\u8fdb\u7ec6\u83cc\u5185\u6e90\u6027\u4f4e\u6d53\u5ea6H2<\/sub>O2<\/sub>\u4ea7\u751f\u5927\u91cf\u6d3b\u6027\u6c27\u7269\u8d28(ROS)\uff0c\u6709\u6548\u7684\u4fc3\u8fdbROS\u5bf9\u7ec6\u83cc\u7684\u6740\u4f24\uff0c\u800c\u4e14\u751f\u7269\u819c\u5fae\u73af\u5883\u7684\u9178\u6027\u548c\u8fd8\u539f\u6027\u8fd8\u53ef\u4ee5\u5bfc\u81f4reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u81ea\u7ec4\u88c5\u4ea7\u751f\u5927\u7684\u805a\u96c6\u4f53\uff0c\u4fc3\u4f7f\u5176\u7d2f\u79ef\u5728\u751f\u7269\u819c\u8868\u9762\uff0c\u540c\u65f6\u589e\u5f3a\u8fd1\u7ea2\u5916\u5149\u70ed\u8f6c\u6362\u6548\u5e94\uff0c\u6781\u5927\u7684\u589e\u5f3a\u4e86\u6297\u83cc\u6548\u679c\u3002\u52a8\u7269\u5b9e\u9a8c\u8fdb\u4e00\u6b65\u8868\u660e\uff0creduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u53ef\u4ee5\u6709\u6548\u6e05\u9664\u611f\u67d3\u4f24\u53e3\u4e2d\u7684\u5927\u80a0\u6746\u83cc(E.<\/i><\/em>\u00a0<\/i><\/em>coli<\/i><\/em>)\uff0c\u5e76\u5feb\u901f\u4fc3\u8fdb\u4f24\u53e3\u7684\u6108\u5408\u3002\u8be5\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cBacteria responsive polyoxometalates nanocluster\u00a0strategy to regulate biofilm microenvironments for\u00a0enhanced synergetic antibiofilm activity and wound\u00a0healing\u201d\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aTheranostics\u4e0a\u3002\u7855\u58eb\u751f\u5f20\u6708\u901a\u548c\u76ae\u6d0b\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u901a\u8baf\u4f5c\u8005\u4e3a\u96cd\u5a9b\u526f\u7814\u7a76\u5458\u3002<\/p>\n

\"\"<\/p>\n

\u56fe\u4e00\u3001GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684\u5236\u5907\u548c\u6297\u83cc\u4f5c\u7528\u793a\u610f\u56fe<\/p>\n

\"\"<\/p>\n

(a)\u00a0\u901a\u8fc7\u91cd\u7ed3\u6676\u65b9\u6cd5\u5408\u6210GdW10<\/sub>O36<\/sub>\u00a0NCs\u53careduced GdW10<\/sub>O36<\/sub>\u00a0NCs\uff1b<\/p>\n

(b)\u00a0reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u5728\u8c03\u63a7\u751f\u7269\u819c\u5fae\u73af\u5883\u5e76\u50ac\u5316\u4ea7\u751fROS\u6740\u6b7b\u7ec6\u83cc\u3002<\/p>\n

\u56fe\u4e8c\u3001GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684\u5236\u5907\u3001\u7ed3\u6784\u4e0e\u6027\u8d28\u8868\u5f81<\/p>\n

\"\"<\/p>\n

GdW10<\/sub>O36<\/sub>\u00a0NCs\u53careduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684(A)\u5236\u5907\u8fc7\u7a0b\uff0c(B-D) TEM\u56fe\u50cf\uff0c(E) TEM\u56fe\u50cf\u76f8\u5e94\u7684\u7c92\u5f84\u5206\u5e03\uff0c(F-G) reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684UV-vis-NIR\u5438\u6536\u5149\u8c31\uff0c(H) reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684XPS\u5168\u8c31\u56fe\uff0c(I-J) GdW10<\/sub>O36<\/sub>\u00a0NCs\u8fd8\u539f\u524d\u540eW\u5143\u7d20\u7684XPS\u8c31\u56fe\u3002<\/p>\n

\u56fe\u4e09\u3001reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684\u5149\u70ed\u6297\u83cc\u6548\u5e94<\/p>\n

\"\"<\/p>\n

reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u5149\u70ed\u6548\u5e94\u7684\u6fc0\u5149\u529f\u7387\u5bc6\u5ea6(A)\u3001\u6d53\u5ea6(B)\u53capH(C)\u4f9d\u8d56\u6027\uff0c\u4e0d\u540cpH\u6761\u4ef6\u4e0breduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u4ea7\u751f\u7684\u5149\u70ed\u6548\u5e94\u7ea2\u5916\u56fe(D)\u3002<\/p>\n

\u56fe\u56db\u3001reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684\u7c7b\u8fc7\u6c27\u5316\u7269\u9176\u6d3b\u6027\u53ca\u50ac\u5316\u673a\u5236<\/p>\n

\"\"<\/p>\n

\u91c7\u7528\u57fa\u5e95TMB (A)\u3001OPD (B)\u548c\u6d3b\u6027\u6c27\u7269\u8d28\u63a2\u9488TA(C)\u63a2\u7d22reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684\u7c7b\u8fc7\u6c27\u5316\u7269\u9176\u6d3b\u6027\uff0c(D-E) reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684\u50ac\u5316\u673a\u5236\u3002<\/p>\n

\u56fe\u4e94\u3001reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684\u6297\u83cc\u6d3b\u6027<\/p>\n

\"\"<\/p>\n

reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u5904\u7406\u540e\u5927\u80a0\u6746\u83cc(A-B)\u548c\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc(C-D)\u7684\u5931\u6d3b\u6548\u7387\u3002<\/p>\n

\u56fe\u516d\u3001reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684\u6297\u751f\u7269\u819c\u6d3b\u6027<\/p>\n

\"\"<\/p>\n

reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u5904\u7406\u540e\u5927\u80a0\u6746\u83cc\u751f\u7269\u819c(A-B)\u548c\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u751f\u7269\u819c(C-D)\u7684\u6291\u5236\u6548\u7387\u3002reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u5904\u7406\u540e\u5927\u80a0\u6746\u83cc\u751f\u7269\u819c\u548c\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u751f\u7269\u819c\u7684\u8367\u5149\u56fe(E)\u3002<\/p>\n

\u56fe\u4e03\u3001reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u7684\u6cbb\u7597\u5c0f\u9f20\u4f24\u53e3\u611f\u67d3<\/p>\n

\"\"<\/p>\n

(A)\u4e0d\u540c\u5904\u7406\u6761\u4ef6\u4e0b\u5c0f\u9f20\u4f24\u53e3\u7684\u6108\u5408\u7a0b\u5ea6\uff1b(B)\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5c0f\u9f20\u4f53\u91cd\u7684\u53d8\u5316\uff1b(C)\u6cbb\u7597\u7ed3\u675f\u540e\u4e0d\u540c\u6761\u4ef6\u4e0b\u5c0f\u9f20\u4f24\u53e3\u7684\u7167\u7247\uff1b(D)\u6cbb\u7597\u7ed3\u675f\u540e\u5c0f\u9f20\u7684\u4f24\u53e3\u7ec4\u7ec7\u5207\u7247\u7684H\uff06E\u3001Masson\u548cGiemsa\u67d3\u8272\u56fe\u3002<\/p>\n

\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u62a5\u9053\u4e86\u4e00\u79cd\u5177\u6709\u7c7b\u8fc7\u6c27\u5316\u7269\u62df\u9176\u50ac\u5316\u6d3b\u6027\u548c\u5149\u70ed\u589e\u5f3a\u50ac\u5316\u6297\u83cc\u80fd\u529b\u7684\u65b0\u578b\u6297\u83cc\u5242(GdW10<\/sub>O36<\/sub>\u00a0NCs)\u3002\u5176\u8fd8\u539f\u578b(reduced GdW10<\/sub>O36<\/sub>\u00a0NCs)\u5177\u6709\u9ad8\u6548\u7684\u5e7f\u8c31\u6297\u83cc\u6d3b\u6027\u548c\u4f18\u5f02\u7684\u7ec6\u83cc\u751f\u7269\u819c\u8c03\u63a7\u6027\u80fd\u3002\u6297\u83cc\u673a\u7406\u7684\u7814\u7a76\u8868\u660e\uff0creduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u5177\u6709\u8fc7\u6c27\u5316\u7269\u7684\u7c7b\u9176\u6d3b\u6027\uff0c\u80fd\u591f\u50ac\u5316\u4f53\u5185\u6781\u4f4e\u6d53\u5ea6H2<\/sub>O2<\/sub>\u4ea7\u751fROS\uff1b\u5e76\u4e14\u5728\u751f\u7269\u819c\u5fae\u73af\u5883\u7684\u9178\u6027\u548c\u8fd8\u539f\u6027\u6761\u4ef6\u4e0b\uff0c reduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u80fd\u591f\u81ea\u7ec4\u88c5\u4ea7\u751f\u5927\u7684\u805a\u96c6\u4f53\uff0c\u4fc3\u4f7f\u5176\u7d2f\u79ef\u5728\u751f\u7269\u819c\u8868\u9762\uff0c\u540c\u65f6\u589e\u5f3a\u8fd1\u7ea2\u5916\u5149\u70ed\u8f6c\u6362\u6548\u5e94\uff0c\u4ece\u800c\u6781\u5927\u5730\u63d0\u9ad8\u5176\u6297\u83cc\u6548\u7387\u548c\u6297\u751f\u7269\u819c\u6d3b\u6027\u3002\u540c\u65f6\uff0c\u4f53\u5916\u548c\u6d3b\u4f53\u7684\u5b9e\u9a8c\u4e5f\u540c\u6837\u8868\u660e\uff0creduced GdW10<\/sub>O36<\/sub>\u00a0NCs\u5177\u6709\u4f18\u5f02\u7684\u6297\u83cc\u6d3b\u6027\u548c\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3002\u603b\u4e4b\uff0c\u8be5\u5de5\u4f5c\u5c55\u793a\u4e86\u4e00\u79cd\u57fa\u4e8eGdW10<\/sub>O36<\/sub>\u00a0NCs\u7684\u65b0\u578b\u6297\u83cc\u5242\uff0c\u4e3a\u63d0\u9ad8\u7ec6\u83cc\u611f\u67d3\u5f15\u8d77\u7684\u75be\u75c5\u6cbb\u6108\u7387\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aBacteria responsive polyoxometalates nanocluster strategy to regulate biofilm microenvironments for enhanced synergetic antibiofilm activity and wound healing\uff08Theranostics,\u00a02020; 10(22): 10031-10045. doi: 10.7150\/thno.49008\uff09<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/b><\/strong><\/p>\n

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