{"id":210016,"date":"2020-09-30T06:30:44","date_gmt":"2020-09-29T22:30:44","guid":{"rendered":"\/\/m.iemloyee.com\/?p=210016"},"modified":"2020-09-29T18:40:48","modified_gmt":"2020-09-29T10:40:48","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91%e7%91%9e%e5%a3%ab%e6%b4%9b%e6%a1%91%e8%81%94%e9%82%a6%e7%90%86%e5%b7%a5%e5%ad%a6%e9%99%a2nature-materials%ef%bc%9a%e4%b8%89%e7%bb%b4%e7%94%9f%e7%89%a9","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=210016","title":{"rendered":"\u745e\u58eb\u6d1b\u6851\u8054\u90a6\u7406\u5de5\u5b66\u9662Nature Materials\uff1a\u4e09\u7ef4\u751f\u7269\u6253\u5370\u9ad8\u6548\u5b9e\u73b0\u5b8f\u89c2\u5c3a\u5ea6\u4e0a\u7ec6\u80de\u81ea\u7ec4\u7ec7"},"content":{"rendered":"<p><strong><b>\u3010\u5f15\u8a00\u3011<\/b><\/strong>\u00a0<\/p>\n<p>\u751f\u7269\u6253\u5370\u7531\u4e8e\u5177\u6709\u5176\u63a7\u5236\u7ec6\u80de\u5927\u89c4\u6a21\u6c89\u79ef\u548c\u751f\u7269\u76f8\u5bb9\u6027\u7684\u5f3a\u5927\u80fd\u529b\uff0c\u5728\u7ec4\u7ec7\u5de5\u7a0b\u548c\u518d\u751f\u533b\u5b66\u4e2d\u5f97\u5230\u4e86\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u867d\u7136\u6700\u8fd1\u5df2\u7ecf\u5f00\u53d1\u4e86\u5148\u8fdb\u7684\u751f\u7269\u6253\u5370\u65b9\u5f0f\uff0c\u5982\u591a\u6750\u6599\u3001\u539f\u4f4d\u3001\u81ea\u7531\u5f62\u5f0f\u548c\u667a\u80fd\u6750\u6599\u751f\u7269\u6253\u5370\uff0c\u4f46\u8fd9\u4e9b\u65b9\u6cd5\u5f80\u5f80\u4e3a\u4e86\u63d0\u9ad8\u6253\u5370\u6027\u548c\u5206\u8fa8\u7387\u800c\u727a\u7272\u4e86\u5176\u7ec6\u80de\u73af\u5883\u9002\u7528\u6027\u3002\u8fd9\u79cd\u6743\u8861\u5df2\u7ecf\u65e0\u6cd5\u4e3a\u91cd\u65b0\u521b\u9020\u590d\u6742\u7684\u5929\u7136\u7ec4\u7ec7\u7ed3\u6784\u548c\u529f\u80fd\u63d0\u4f9b\u6240\u5fc5\u9700\u7684\u9ad8\u7ec6\u80de\u5bc6\u5ea6\u548c\u5141\u8bb8\u6027\u3002\u5728\u4f53\u5185\uff0c\u7ec4\u7ec7\u7684\u5f62\u6210\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4f9d\u8d56\u4e8e\u4e25\u683c\u8c03\u63a7\u7684\u5f62\u6001\u53d1\u751f\u7a0b\u5e8f\uff0c\u8be5\u7a0b\u5e8f\u5141\u8bb8\u7ec6\u80de\u7fa4\u8fdb\u884c\u5c40\u90e8\u76f8\u4e92\u4f5c\u7528\u548c\u81ea\u6211\u7ec4\u7ec7\u3002\u8fd9\u4e9b\u5c40\u90e8\u53d1\u80b2\u7684\u7ec4\u7ec7\u5355\u4f4d\u4e4b\u95f4\u7684\u8fed\u4ee3\u76f8\u4e92\u4f5c\u7528\u6307\u5bfc\u4e86\u7ec6\u80de\u5206\u5316\u548c\u6a21\u5f0f\u5f62\u6210\u7684\u8fde\u7eed\u5faa\u73af\uff0c\u4ece\u800c\u5efa\u7acb\u4e86\u5927\u89c4\u6a21\u7684\u751f\u7269\u590d\u6742\u6027\u3002\u7531\u4e8e\u5176\u72ec\u7279\u7684\u81ea\u7ec4\u7ec7\u6f5c\u529b\uff0c\u5e72\u7ec6\u80de\u6e90\u6027\u5668\u5b98\u662f\u4e00\u79cd\u5f88\u6709\u524d\u9014\u7684\u7ec4\u7ec7\u6a21\u4eff\uff0c\u5728\u590d\u5236\u7ec4\u7ec7\u7ed3\u6784\u548c\u7ec6\u80de\u7c7b\u578b\u7ec4\u6210\u7684\u5c40\u90e8\u7279\u5f81\u65b9\u9762\uff0c\u8fd9\u662f\u5de5\u7a0b\u65b9\u6cd5\u6240\u65e0\u6cd5\u6bd4\u62df\u7684\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5668\u5b98\u4e0d\u80fd\u751f\u957f\u8d85\u8fc7\u6beb\u7c73\u7ea7\uff0c\u5b83\u4eec\u7f3a\u4e4f\u539f\u751f\u5668\u5b98\u7684\u7ed3\u6784\u7279\u5f81\uff0c\u800c\u8fd9\u4e9b\u56fa\u6709\u7279\u5f81\u5c06\u5141\u8bb8\u51fa\u73b0\u66f4\u9ad8\u7ea7\u522b\u7684\u529f\u80fd\u7279\u5f81\u3002\u518d\u751f\u533b\u5b66\u4f53\u5916\u7ec4\u7ec7\u5668\u5b98\u53d1\u80b2\u7684\u4e00\u4e2a\u91cd\u8981\u6b65\u9aa4\u662f\uff0c\u5728\u5b8f\u89c2\u5c3a\u5ea6\u4e0a\u63a7\u5236\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u7684\u81ea\u7ec4\u7ec7\u6f5c\u80fd\uff0c\u4f46\u8fd9\u5bf9\u73b0\u6709\u6280\u672f\u4ecd\u7136\u5177\u6709\u6311\u6218\u6027\u3002\u5bf9\u7ec4\u7ec7\u5927\u5c0f\u548c\u7ed3\u6784\u7684\u66f4\u597d\u63a7\u5236\u6700\u7ec8\u53ef\u4ee5\u63d0\u4f9b\u7528\u4e8e\u836f\u7269\u7b5b\u9009\u6216\u6700\u7ec8\u5668\u5b98\u66ff\u4ee3\u7684\u4eba\u9020\u5668\u5b98\uff0c\u4ece\u800c\u51cf\u8f7b\u52a8\u7269\u6d4b\u8bd5\u7684\u8d1f\u62c5\u5e76\u6d88\u9664\u79fb\u690d\u7684\u6f2b\u957f\u7b49\u5f85\u65f6\u95f4\u3002<\/p>\n<p>\u8fd1\u65e5\uff0c<strong><b>\u745e\u58eb\u6d1b\u6851\u8054\u90a6\u7406\u5de5\u5b66\u9662Matthias P. Lutolf<\/b><\/strong><strong><b>\u6559\u6388<\/b><\/strong><strong><b>\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/b><\/strong>\u5f15\u5165\u4e86\u4e00\u79cd\u4e09\u7ef4\uff083D\uff09\u751f\u7269\u6253\u5370\u6982\u5ff5\uff0c\u7528\u4e8e\u6307\u5bfc\u5728\u751f\u7406\u76f8\u5173\u7684\u5c3a\u5ea6\u4e0a\u5e76\u76f4\u63a5\u5728\u9ad8\u5ea6\u8bb8\u53ef\u7684\u7ec6\u80de\u5916\u57fa\u8d28\uff08ECM\uff09\u4e2d\u5f15\u5bfc\u7ec4\u7ec7\u5f62\u6001\u53d1\u751f\uff0c\u4ece\u800c\u4fc3\u8fdb\u6709\u6548\u7684\u591a\u7ec6\u80de\u81ea\u7ec4\u7ec7\u3002\u672c\u6587\u7684\u65b9\u6cd5\u88ab\u79f0\u4e3a\u751f\u7269\u6253\u5370\u8f85\u52a9\u7ec4\u7ec7\u51fa\u73b0\uff08BATE\uff09\uff0c\u5b83\u4f7f\u7528\u5e72\u7ec6\u80de\u548c\u7c7b\u5668\u5b98\u4f5c\u4e3a\u81ea\u53d1\u81ea\u7ec4\u7ec7\u7684\u6784\u5efa\u57fa\u5757\uff0c\u8fd9\u4e9b\u6784\u5efa\u57fa\u5757\u53ef\u4ee5\u5728\u7a7a\u95f4\u4e0a\u6392\u5217\u4ee5\u5f62\u6210\u76f8\u4e92\u8fde\u63a5\u548c\u8fdb\u5316\u7684\u7ec6\u80de\u7ed3\u6784\u3002\u56e0\u6b64\uff0c\u901a\u5e38\u4f1a\u53d1\u5c55\u6210\u76f8\u5bf9\u968f\u673a\u5f62\u72b6\u7684\u5c0f\u7c7b\u5668\u5b98\u7684\u6bcf\u4e2a\u7ec6\u80de\u6216\u7ec6\u80de\u805a\u96c6\u4f53\uff0c\u90fd\u53ef\u4ee5\u6309\u71673D\u6253\u5370\u65bd\u52a0\u7684\u51e0\u4f55\u5f62\u72b6\u548c\u7ea6\u675f\uff0c\u5f3a\u5236\u878d\u5408\u5e76\u91cd\u65b0\u7ec4\u7ec7\u3002\u4f7f\u7528\u8fd9\u79cd\u901a\u7528\u7b56\u7565\uff0c\u53ef\u4ee5\u6253\u5370\u51fa\u5177\u6709\u5173\u952e\u7ec6\u80de\u7c7b\u578b\u7684\u5927\u578b\u7ec6\u80de\u7ed3\u6784\uff0c\u4f8b\u5982\u8584\u58c1\u7ec4\u7ec7\u53ca\u5176\u76f8\u5e94\u7684\u57fa\u8d28\u6216\u80c3\u80a0\u9053\u4e2d\u7684\u4e0d\u540c\u4e0a\u76ae\u7ec6\u80de\uff0c\u4ee5\u91cd\u73b0\u5728\u5929\u7136\u5668\u5b98\u4e2d\u770b\u5230\u7684\u7ec4\u7ec7\u4e0e\u7ec4\u7ec7\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u6216\u4f53\u5185\u5e73\u8861\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u4ee5\u201c<strong><b>Recapitulating macro-scale tissue self-organization through organoid bioprinting<\/b><\/strong>\u201d\u4e3a\u9898\u53d1\u8868\u5728<strong><em><b><i>Nature Materials<\/i><\/b><\/em><\/strong>\u4e0a\u3002<\/p>\n<p><strong><b>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n<p><strong><b>\u56fe\u4e00<\/b><\/strong><strong><b>\u3001BATE<\/b><\/strong><strong><b><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-210017\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/\u56fe1-12.jpg\" alt=\"\" width=\"600\" height=\"772\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/\u56fe1-12.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/\u56fe1-12-233x300.jpg 233w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/\u56fe2-12.jpg\" alt=\"\" width=\"600\" height=\"859\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/\u56fe2-12.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/\u56fe2-12-210x300.jpg 210w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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href=\"https:\/\/www.nature.com\/articles\/s41563-020-00803-5\"><strong><u><b>Recapitulating macro-scale tissue self-organization through organoid bioprinting<\/b><\/u><\/strong><\/a><strong><b>\u201d(<\/b><\/strong><strong><b>Nature Materials<\/b><\/strong><strong><b>\uff0c<\/b><\/strong><strong><b>2020\uff0c<\/b><\/strong><strong><b>10.1038\/s41563-020-00803-5<\/b><\/strong><strong><b>)<\/b><\/strong><\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4ebaCYM\u7f16\u8bd1\u4f9b\u7a3f\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011\u00a0 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