{"id":209575,"date":"2020-09-22T06:06:02","date_gmt":"2020-09-21T22:06:02","guid":{"rendered":"\/\/m.iemloyee.com\/?p=209575"},"modified":"2020-09-21T21:06:24","modified_gmt":"2020-09-21T13:06:24","slug":"adv-mater-%e6%8a%a5%e9%81%93%ef%bc%9a%e7%ba%b3%e7%b1%b3%e7%96%ab%e8%8b%97%ef%bc%81%e7%94%9f%e7%89%a9%e4%bd%93%e5%86%85%e5%90%88%e6%88%90%e7%9a%84%e3%80%81%e8%87%aa%e7%bb%84%e8%a3%85%e8%9b%8b","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=209575","title":{"rendered":"Adv. Mater. 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srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/2-28.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/2-28-300x228.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\uff08a\uff09\u5bf9\u7167\u7ec6\u80de\u548c\u8868\u8fbe\u7eb3\u7c73\u9897\u7c92\u7684\u7ec6\u80de\u7684TEM\u56fe\u50cf\uff0c\u514d\u75ab\u8367\u5149\u6cd5\u68c0\u6d4b\u8868\u8fbe\u86cb\u767d\uff1b<\/p>\n<p>\uff08b\uff09\u7eaf\u5316\u7684\u7eb3\u7c73\u9897\u7c92\u7684TEM\u56fe\u50cf\uff0c\u4ee5\u53ca\u7eb3\u7c73\u9897\u7c92\u5355\u4f53\u7684SDS-PAGE\u5206\u6790\uff1b<\/p>\n<p>\uff08c\uff09\u7eb3\u7c73\u9897\u7c92\u6eb6\u6db2\u7684\u4e01\u8fbe\u5c14\u6548\u5e94\u53ca\u5176\u5728\u5ba4\u6e29\u4e0b\u653e\u7f6e48 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\/>\uff08a\uff09\u8bc4\u4f30\u7eb3\u7c73\u75ab\u82d7\u9884\u9632\u6027\u80fd\u7684\u514d\u75ab\u6d41\u7a0b\u56fe\uff1b<\/p>\n<p>\uff08b\uff09\u7528PBS\u3001OPS\u3001OPS+Al\uff08\u6c22\u6c27\u5316\u94dd\uff09\u3001C-OPS\u3001NP-OPS\u514d\u75ab\u7684BALB\/c\u5c0f\u9f20\u540e\u68c0\u6d4b\u8840\u6e05\u4e2d\u6297\u798f\u6c0f\u5fd7\u8d3a\u6c0f\u83cc2a\u578b301\u682a\u7684LPS\u7684IgG\u4e9a\u578b\u6548\u4ef7\uff1b<\/p>\n<p>\uff08c\uff09\uff08b\uff09\u4e2d\u8840\u6e05\u7ecf\u4e0d\u540c\u7a00\u91ca\u5ea6\u5904\u7406\u540e\u7684\u8840\u6e05\u6740\u83cc\u6d3b\u6027\uff1b<\/p>\n<p>\uff08d\uff09\u5728\u672b\u6b21\u514d\u75ab\u4e24\u5468\u540e\uff0c\u5229\u7528301\u91ce\u751f\u682a\u5bf9\u5c0f\u9f20\u8fdb\u884c\u8179\u8154\u653b\u6bd2\uff08\u6bcf\u53ea\u5c0f\u9f20\u7ea64.35\u00d710<sup>7<\/sup> CFU\u611f\u67d3\u91cf\uff09\uff0c\u89c2\u5bdf\u5c0f\u9f20\u5b58\u6d3b\u60c5\u51b5\uff1b<\/p>\n<p>\uff08e\uff09\u901a\u8fc7\u8179\u819c\u5185\u6ce8\u5c04\u8367\u5149\u7d20\u9176\u6807\u8bb0\u7684\u798f\u6c0f\u5fd7\u8d3a\u6c0f\u83cc2a\u578b301\u682a\u89c2\u5bdf\u514d\u75ab\u5c0f\u9f20\u7684\u4f53\u5185\u6740\u83cc\u6d3b\u6027\u3002<\/p>\n<p><strong>\u56fe\u516d\u3001\u8d1f\u8f7dOVA SL8\u80bd\u7684\u7eb3\u7c73\u75ab\u82d7\u901a\u8fc7\u8bf1\u5bfc\u5f3a\u70c8\u7684\u7ec6\u80de\u514d\u75ab\u5e94\u7b54\u6765\u6291\u5236\u80bf\u7624\u751f\u957f<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-209581\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/6-9.jpg\" alt=\"\" width=\"600\" height=\"767\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/6-9.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/6-9-235x300.jpg 235w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\uff08a\uff09\u8bc4\u4f30\u7eb3\u7c73\u75ab\u82d7\u80bf\u7624\u6cbb\u7597\u6548\u679c\u7684\u6d41\u7a0b\u56fe\uff1b<\/p>\n<p>\uff08b\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4\u4e2d\u5c0f\u9f20\u7684\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n<p>\uff08c\uff09\uff08b\uff09\u4e2d\u5404\u7ec4\u5c0f\u9f20\u7684\u5b58\u6d3b\u65f6\u95f4\uff1b<\/p>\n<p>\uff08d\uff09\u80bf\u7624\u7ec4\u7ec7\u7684\u51cb\u4ea1\u548c\u589e\u6b96\u7684\u514d\u75ab\u8367\u5149\u5207\u7247\uff1b<\/p>\n<p>\uff08e\uff0923\u5929\u65f6\u5404\u7ec4\u5c0f\u9f20\u7684\u80bf\u7624\u91cd\u91cf\uff1b<\/p>\n<p>\uff08f\uff09\u80bf\u7624\u7ec4\u7ec7\u4e2d\u6d78\u6da6\u7684CD8<sup>+<\/sup>T\u7ec6\u80de\u7684\u514d\u75ab\u8367\u5149\u5207\u7247\uff1b<\/p>\n<p>\uff08g\uff09\u80bf\u7624\u4e2dCD8<sup>+<\/sup>T\u7ec6\u80de\u7684\u6bd4\u4f8b\uff1b<\/p>\n<p>\uff08h\uff09\u80bf\u7624\u7ec4\u7ec7\u4e2d\u6d78\u6da6\u7684CD8<sup>+<\/sup>T\u7ec6\u80de\u4e2d\u5206\u6ccc\u9897\u7c92\u9176B\u548cIFN-\u03b3\u7684\u7ec6\u80de\u767e\u5206\u6bd4\u3002<\/p>\n<p><strong>\u56fe\u4e03\u3001\u5728\u98df\u87f9\u7334\u4e2d\u8bc4\u4f30\u7eb3\u7c73\u75ab\u82d7\u7684\u6027\u80fd<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-209582\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/7-6.jpg\" alt=\"\" width=\"600\" height=\"651\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/7-6.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/09\/7-6-276x300.jpg 276w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\uff08a\uff09\u5728\u98df\u87f9\u7334\u4e2d\u8bc4\u4f30\u6cbb\u7597\u65b9\u6848\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b\uff09\u7eb3\u7c73\u75ab\u82d7\u9012\u9001\u81f3\u5f15\u6d41\u6dcb\u5df4\u7ed3\uff08dLNs\uff09\uff1b<\/p>\n<p>\uff08c\uff09\u5728\u4e0d\u540c\u75ab\u82d7\u514d\u75ab\u540e\uff0cdLNs\u7684\u5927\u5c0f\u53d8\u5316\uff1b<\/p>\n<p>\uff08d\uff09\u9488\u5bf9\u7532\u578b\u526f\u4f24\u5bd2\u6c99\u95e8\u6c0f\u83ccCMCC 50973\u682a\u7684LPS\u7684IgG\u6548\u4ef7\u8bc4\u4ef7\uff1b<\/p>\n<p>\uff08e\uff09\u6297\u4f53\u8bf1\u5bfc\u7684\u9488\u5bf9\u7532\u578b\u526f\u4f24\u5bd2\u6c99\u95e8\u6c0f\u83cc\u7684\u8840\u6e05\u6740\u83cc\u4f5c\u7528\uff1b<\/p>\n<p>\uff08f\uff09\u8840\u6db2\u4e2dCD8<sup>+<\/sup>T\u7ec6\u80de\u4e2d\u9897\u7c92\u9176B\u7684\u8868\u8fbe\uff1b<\/p>\n<p>\uff08g\uff09\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u5bf9\u611f\u67d3\u7ec6\u80de\u7684\u88c2\u89e3\u80fd\u529b\uff1b<\/p>\n<p>\uff08h-i\uff09\u7eb3\u7c73\u75ab\u82d7\u7684\u5b89\u5168\u6027\u8bc4\u4ef7\u3002<\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u8be5\u5de5\u4f5c\u8868\u660e\u6b64\u7eb3\u7c73\u75ab\u82d7\u5728\u7075\u957f\u7c7b\u52a8\u7269\u548c\u5c0f\u9f20\u4e2d\u5747\u5177\u6709\u5f88\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u5e76\u4e14\u5728\u9ad8\u6548\u6fc0\u53d1\u673a\u4f53\u514d\u75ab\u5e94\u7b54\u65b9\u9762\u4f18\u4e8e\u5e38\u89c4\u75ab\u82d7\u3002\u4f5c\u4e3a\u4e00\u9879\u521b\u65b0\u6280\u672f\uff0c\u7eb3\u7c73\u75ab\u82d7\u4e2d\u7684\u591a\u7cd6\u6297\u539f\u662f\u7531\u7ec6\u83cc\u81ea\u8eab\u5408\u6210\uff0c\u53ef\u786e\u4fdd\u5176\u5929\u7136\u6784\u8c61\u5e76\u4fdd\u6301\u6297\u539f\u7684\u4fdd\u771f\u5ea6\uff0c\u6709\u5229\u4e8e\u6fc0\u53d1\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u3002\u5c06\u6765\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u8fdb\u4e00\u6b65\u6d4b\u8bd5\u8be5\u7eb3\u7c73\u75ab\u82d7\u5bf9\u96be\u4ee5\u7528\u6297\u751f\u7d20\u6cbb\u7597\u7684\u591a\u91cd\u8010\u836f\u7ec6\u83cc\u548c\u80de\u5185\u7ec6\u83cc\u7684\u9884\u9632\u80fd\u529b\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8bc1\u5b9e\u4e86\u5927\u5206\u5b50\u91cf\u591a\u7cd6\u94fe\uff08\u8d85\u8fc730 kDa\uff09\u4e0e\u7eb3\u7c73\u9897\u7c92\u7684\u6210\u529f\u8fde\u63a5\uff0c\u4e3a\u66f4\u957f\u7684\u80bd\u6bb5\u751a\u81f3\u86cb\u767d\u8d28\u7ed3\u6784\u57df\u5728\u7eb3\u7c73\u5e73\u53f0\u8868\u9762\u7684\u5c55\u793a\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\u3002\u9488\u5bf9SARS-CoV-2\u5bf9\u516c\u5171\u5065\u5eb7\u7684\u5a01\u80c1\uff0c\u4f5c\u8005\u8ba4\u4e3a\u8be5Nano-B5\u5e95\u76d8\u4e5f\u53ef\u4ee5\u901a\u8fc7\u5c55\u793aS\u86cb\u767d\u7684\u53d7\u4f53\u7ed3\u5408\u7ed3\u6784\u57df\uff0c\u7528\u4f5c\u5feb\u901f\u5f00\u53d1\u6709\u6548\u7684\u6297\u75c5\u6bd2\u7eb3\u7c73\u75ab\u82d7\u7684\u5de5\u5177\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u57fa\u4e8eNano-B5\u7684\u6a21\u5757\u5316\u8bbe\u8ba1\uff0c\u6709\u52a9\u4e8e\u6dcb\u5df4\u7ed3\u9776\u5411\u7684\u591a\u6297\u539f\u7eb3\u7c73\u75ab\u82d7\u7684\u7814\u5236\u3002\u6b64\u5916\uff0c\u8003\u8651\u5230\u8fd9\u4e9b\u6a21\u5757\u8bbe\u8ba1\u6700\u7ec8\u88ab\u7f16\u7801\u4e3a\u7a33\u5b9a\u7684DNA\uff0c\u56e0\u800c\u53ef\u9002\u7528\u4e8e\u6f5c\u5728\u7684\u591a\u79cd\u4e0d\u540c\u7ec6\u80de\u5bbf\u4e3b\uff0c\u5e76\u8fdb\u884c\u5206\u6790\u3001\u6d4b\u8bd5\u548c\u5e94\u7528\uff0c\uff0c\u800c\u8fd9\u4e9b\u5e95\u76d8\u672c\u8eab\u4e5f\u53ef\u4ee5\u901a\u8fc7\u5de5\u7a0b\u8bbe\u8ba1\u4ee5\u652f\u6301\u591a\u79cd\u529f\u80fd\u5316\u4fee\u9970\uff0c\u4ece\u800c\u63d0\u9ad8\u7279\u5f02\u6027\u548c\u6539\u5584\u75ab\u82d7\u6027\u80fd\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/adma.202002940\" target=\"_blank\" rel=\"noopener\">Biosynthesis of Self-Assembled Proteinaceous Nanoparticles for Vaccination<\/a><\/strong>.\uff08<em>Adv. Mater.<\/em>, <strong>2020<\/strong>, DOI:10.1002\/adma.202002940\uff09<\/p>\n<p style=\"text-align: center;\"><strong>\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n<p><strong>\u4e2d\u79d1\u9662\u8fc7\u7a0b\u5de5\u7a0b\u7814\u7a76\u6240\u9a6c\u5149\u8f89\u7814\u7a76\u5458\u548c\u9b4f\u709c\u7814\u7a76\u5458\u56e2\u961f<\/strong>\u81ea2006\u5e74\u8d77\u5bf9\u5148\u8fdb\u75ab\u82d7\u9012\u9001\u7cfb\u7edf\u8fdb\u884c\u4e86\u7387\u5148\u63a2\u7d22\u548c\u6df1\u5165\u7814\u7a76\uff0c\u53d1\u73b0\u548c\u521b\u5236\u4e86\u4e00\u7cfb\u5217\u75ab\u82d7\u65b0\u5242\u578b\uff0c\u89e3\u51b3\u4e86\u6297\u539f\u514d\u75ab\u539f\u6027\u5dee\u3001\u751f\u7269\u5229\u7528\u5ea6\u4f4e\u7b49\u96be\u9898\uff0c\u5728\u80bf\u7624\u3001\u4e59\u809d\u3001\u6d41\u611f\u7b49\u91cd\u5927\u75be\u75c5\u548c\u4f20\u67d3\u75c5\u7684\u9884\u9632\u548c\u6cbb\u7597\u4e0a\u53d6\u5f97\u663e\u8457\u7597\u6548\uff0c\u90e8\u5206\u5242\u578b\u5df2\u901a\u8fc7\u4f26\u7406\u6279\u51c6\u8fdb\u5165\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\uff0c\u76f8\u5173\u5de5\u4f5c\u76f8\u7ee7\u53d1\u8868\u4e8e<em>Nat. Mater.<\/em>, <strong>2018<\/strong>, <em>17<\/em>, 187\u3001<em>Nat. Commun.<\/em>, <strong>2017<\/strong>, <em>8<\/em>, 14537\u3001<em>Sci. Adv.<\/em>, <strong>2020<\/strong>, <em>6<\/em>, eaay7735\u3001<em>Adv. Mater.<\/em>, <strong>2018<\/strong>, <em>31<\/em>, 1801067\u3001<em>Adv. Sci.<\/em>, <strong>2017<\/strong>, <em>4<\/em>, 1700083\u3001<em>ACS Cent. Sci.<\/em>, <strong>2019<\/strong>, <em>5<\/em>, 796\u3001<em>Small<\/em>, <strong>2018<\/strong>, <em>14<\/em>, 1704272\u3001<em>Biomaterials<\/em>, <strong>2015<\/strong>, <em>41<\/em>, 1\u7b49\u671f\u520a\u4e0a\u3002<\/p>\n<p><strong>\u5317\u4eac\u751f\u7269\u6280\u672f\u7814\u7a76\u6240\u738b\u6052\u6a11\u7814\u7a76\u5458\u548c\u6731\u529b\u526f\u7814\u7a76\u5458\u56e2\u961f<\/strong>\u957f\u671f\u81f4\u529b\u4e8e\u7ec6\u83cc\u591a\u7cd6\u7ed3\u5408\u75ab\u82d7\u7684\u751f\u7269\u5408\u6210\u7814\u7a76\uff0c\u91c7\u7528\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u7ec6\u83cc\u86cb\u767dO-\u7cd6\u57fa\u5316\u7cfb\u7edf\u6210\u529f\u5408\u6210\u4e86\u9488\u5bf9\u5fd7\u8d3a\u6c0f\u83cc\u3001\u7532\u578b\u526f\u4f24\u5bd2\u6c99\u95e8\u6c0f\u83cc\u3001\u5e03\u6c0f\u6746\u83cc\u7b49\u65b0\u578b\u75ab\u82d7\uff0c\u9769\u65b0\u4e86\u4f20\u7edf\u7684\u7ec6\u83cc\u591a\u7cd6\u7ed3\u5408\u75ab\u82d7\u5236\u5907\u65b9\u6cd5\uff0c\u76f8\u5173\u5de5\u4f5c\u76f8\u7ee7\u53d1\u8868\u4e8e<em>ACS Appl. Mater. 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