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\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

\u5316\u5b66\u52a8\u529b\u7597\u6cd5\uff08CDT\uff09\u5229\u7528Fenton\u53cd\u5e94\u6216\u8005\u7c7bFenton\u53cd\u5e94\u4ea7\u751f\u9ad8\u5ea6\u6709\u5bb3\u7684\u6d3b\u6027\u6c27\uff08ROS\uff09\uff0c\u65e2\u4e0d\u4f9d\u8d56\u5206\u5b50\u6c27\uff08O2<\/sub>\uff09\uff0c\u4e5f\u4e0d\u4f9d\u8d56\u5916\u90e8\u5149\u6e90\uff0c\u4f7f\u5f97\u5176\u907f\u514dPDT\u7684\u4e3b\u8981\u7f3a\u70b9\uff08\u4e4f\u6c27\u548c\u5149\u6e17\u900f\u6df1\u5ea6\uff09\uff0c\u56e0\u6b64\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u6709\u524d\u9014\u7684\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u3002\u5c3d\u7ba1CDT\u6280\u672f\u5177\u6709\u5de8\u5927\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u4f46\u4ecd\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5\u3002\u76ee\u524d\uff0c\u8be5\u65b9\u6cd5\u7684\u4e00\u4e2a\u4e3b\u8981\u95ee\u9898\u662f\u4f7f\u7528\u8fc7\u91cf\u7684\u5916\u6e90\u6027Fenton\u7c7b\u91cd\u91d1\u5c5e\uff08\u5982Fe\uff0cMn\uff0cCu\u548cCo\u7b49\uff09\uff0c\u8fd9\u53ef\u80fd\u5bf9\u4eba\u4f53\u5065\u5eb7\u9020\u6210\u6f5c\u5728\u7684\u4e0d\u5229\u5f71\u54cd\uff0c\u9020\u6210\u6025\u6027\u6bd2\u6027\u6216\u6162\u6027\u6bd2\u6027\u3002\u4f5c\u4e3a\u751f\u7269\u7cfb\u7edf\u4e2d\u6700\u4e30\u5bcc\u7684\u8fc7\u6e21\u91d1\u5c5e\uff0c\u94c1\u5728\u8bb8\u591a\u7ec6\u80de\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u5982DNA\u5408\u6210\u3001\u7ec6\u80de\u5468\u671f\u8c03\u8282\u548c\u7ec6\u80de\u589e\u6b96\u3002\u7ec6\u80de\u5185\u6709\u4e00\u5c0f\u90e8\u5206\u6e38\u79bb\u6216\u677e\u6563\u7ed3\u5408\u7684\u7ec6\u80de\u5185\u94c1\uff08II\uff09\uff0c\u79f0\u4e3a\u4e0d\u7a33\u5b9a\u94c1\u6c60\uff08LIP\uff09\uff0c\u5177\u6709\u6c27\u5316\u8fd8\u539f\u6d3b\u6027\uff0c\u56e0\u6b64\u5177\u6709\u53c2\u4e0e\u7ec6\u80de\u5185Fenton\u578b\u53cd\u5e94\u4ea7\u751f\u81ea\u7531\u57fa\u7684\u80fd\u529b\u3002\u7136\u800c\uff0c\u5173\u4e8e\u5185\u6e90\u6027LIP\u5728\u57fa\u4e8eFenton\u5316\u5b66\u7684\u6297\u80bf\u7624CDT\u4e2d\u7684\u5e94\u7528\u7814\u7a76\u8f83\u5c11\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5e7f\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e09\u533b\u9662\u9648\u667a\u6bc5\u6559\u6388\u8054\u5408\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u9648\u5c0f\u5143\u6559\u6388<\/strong>\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u7684CDT\u7b56\u7565\uff1a\u5229\u7528\u7ec6\u80de\u5185\u4e0d\u7a33\u5b9a\u94c1\u6c60\uff08LIP\uff09\u4f5c\u4e3aFenton\u6d3b\u6027\u91d1\u5c5e\u7684\u6765\u8bf1\u5bfc\u81ea\u7531\u57fa\u7684\u4ea7\u751f\u3002\u901a\u8fc7\u6a21\u62df\u8fc7\u6c27\u5316\u7269\u5316\u5408\u7269\u5728\u7ec6\u80de\u5185\u7684\u4ee3\u8c22\u9014\u5f84\uff0c\u53d1\u73b0R`OOH\u5728\u4e0d\u7a33\u5b9a\u7684Fe2+<\/sup>\u5b58\u5728\u4e0b\u5177\u6709\u826f\u597d\u7684\u81ea\u7531\u57fa\u751f\u6210\u80fd\u529b\uff0c\u5e76\u4e14\u53ea\u53d7\u5230GSH\/GPx\u7684\u9002\u5ea6\u6e05\u9664\uff0c\u8fd9\u662f\u5176\u4f18\u8d8a\u7684\u5316\u5b66\u52a8\u529b\u5b66\u6548\u5e94\u7684\u539f\u56e0\u3002LIP\u542f\u52a8\u4e86R`OOH\u4ece\u65e0\u6bd2\u5230\u9ad8\u6bd2\u7684\u8f6c\u53d8\uff0c\u518d\u52a0\u4e0a\u80bf\u7624\u7ec6\u80de\u4e2dLIP\u6c34\u5e73\u7684\u589e\u52a0\uff0c\u4f7f\u80bf\u7624\u7ec6\u80de\u7684\u7279\u5f02\u6027\u53ca\u9ad8\u6548\u7684CDT\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u5236\u5907\u4e86pH\/\u4e0d\u7a33\u5b9aFe2+<\/sup>\u7ea7\u8054\u53cd\u5e94\u7eb3\u7c73\u836f\u7269\uff0c\u8be5\u7eb3\u7c73\u836f\u7269\u7531\u5305\u88f9\u5728pH\u654f\u611f\u805a\u5408\u7269\u9897\u7c92\u4e2d\u7684\u4e9a\u6cb9\u9178\u7532\u916f\u548cLIP\u589e\u654f\u5242\u7ec4\u6210\uff0c\u4ee5\u5b9e\u73b0\u589e\u5f3aCDT\u3002\u8fd9\u9879\u5de5\u4f5c\u4e0d\u4ec5\u4e3a\u5229\u7528\u5185\u6e90\u6027Fenton\u578b\u91d1\u5c5e\u6cbb\u7597\u80bf\u7624\u94fa\u5e73\u4e86\u9053\u8def\uff0c\u800c\u4e14\u4e3a\u63a2\u7d22\u7ec6\u80de\u5185LIP\u6fc0\u6d3b\u7684\u9ad8\u6548\u5316\u5b66\u52a8\u529b\u5b66\u836f\u7269\u63d0\u4f9b\u4e86\u4e00\u4e2a\u8303\u4f8b\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cEndogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aJ. Am. Chem. Soc.<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u57fa\u4e8e<\/strong>LIP<\/strong>\u7684<\/strong>CDT<\/strong>\u9884\u6d4b\u53ca\u5b9e\u9a8c\u63a2\u7d22<\/strong><\/p>\n

\"\"<\/p>\n

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\u56fe\u4e8c\u3001\u4f53\u5916<\/strong>ROOR<\/strong>\u8bf1\u5bfc\u7684\u4e0d\u7a33\u5b9a\u94c1\u6c60\u5f15\u53d1\u7684<\/strong>CDT<\/strong><\/p>\n

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\uff08b\uff09\u5728\u6709\u65e0\u94c1\u87af\u5408\u5242DFO\u7684\u4f53\u5916CDT\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n

\uff08c\uff09\u7528\u4e0d\u540c\u7684R`OOH\uff08\u5305\u62ect-BH\u3001CH\u548cMLH\uff09\u6cbb\u759724\u5c0f\u65f6\u540e\u80bf\u7624\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n

\uff08d\uff09\u4e0d\u540c\u6d53\u5ea6MLH\u4f5c\u7528\u4e0bU87MG\u7ec6\u80de\u7684\u6b7b\/\u6d3b\u67d3\u8272\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e09\u3001<\/strong>MLH<\/strong>\u6cbb\u7597\u6076\u6027\u80bf\u7624<\/strong>CDT<\/strong>\u7684\u673a\u5236\u63a2\u8ba8<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5728\u6709\u65e0DFO\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff08200 \u03bcM\uff09\uff0c\u7528\u4e0d\u540c\u6d53\u5ea6\u7684MLH\u5904\u7406\u7684U87MG\u7ec6\u80de\u7684DCF\u8367\u5149\u3002<\/p>\n

\uff08b\uff09C11-BODIPY581\/591<\/sup>\u67d3\u8272\u7684\u80bf\u7624\u7ec6\u80de\u5728\u6709\u65e0DFO\u66b4\u97324\u5c0f\u65f6\u540e\u7684\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\u56fe\u56db\u3001<\/strong>ROS<\/strong>\u7684\u79ef\u7d2f\u5f15\u8d77\u7ec6\u80de\u51cb\u4ea1<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08b\uff09\u7528\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\u4e0d\u540c\u6d53\u5ea6MLH\u5904\u740612h\u540e\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n

\u56fe\u4e94\u3001\u8f7d<\/strong>MLH<\/strong>\u7684<\/strong>CDT<\/strong>\u7eb3\u7c73\u6750\u6599\u7684\u5236\u5907\u4e0e\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08b\uff09MLH\/Era\u8d1f\u8f7dPEG-PDPA NPs\u4f5c\u4e3a\u5f3a\u5316CDT\u7eb3\u7c73\u5236\u5242\u7684\u5408\u6210\u793a\u610f\u56fe\u3002<\/p>\n

\uff08c\uff09PEG-PDPA NPs\u5728pH\u503c\u4e3a7.4\uff08\u5de6\uff09\u62165.5\uff08\u53f3\uff09\u7684\u7f13\u51b2\u6eb6\u6db2\u4e2d\u5206\u656330\u5206\u949f\u540e\u7684TEM\u56fe\u50cf\u3002<\/p>\n

\uff08d\uff09\u7528\u6e38\u79bbPEG-PDPA NPs\u3001MLH\u8d1f\u8f7dPEG-PDPA NPs\u6216MLH\/Era\u8d1f\u8f7dPEG-PDPA NPs\u5904\u740624\u5c0f\u65f6\u540e\uff0cU87MG\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n

\uff08e\uff09AO\u67d3\u8272\u6cd5\u663e\u793a\u66b4\u9732\u4e8e\u5177\u6709\u9178\u5f15\u53d1\u5206\u89e3\u7279\u6027\u7684CDT\u7eb3\u7c73\u5236\u5242\u4e2d\u7684U87MG\u7ec6\u80de\u6eb6\u9176\u4f53\u7834\u88c2\u3002<\/p>\n

\u56fe\u516d\u3001<\/strong>CDT<\/strong>\u7eb3\u7c73\u5236\u5242\u5728\u4f53\u5185\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u5e94\u7528<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08b\uff09\u7528PET\u56fe\u50cf\u6d4b\u91cf89<\/sup>Zr\u6807\u8bb0CDT\u7eb3\u7c73\u5236\u5242\u7684\u80bf\u7624\u6444\u53d6\u3002<\/p>\n

\uff08c\uff0989<\/sup>Zr\u6807\u8bb0CDT\u7eb3\u7c73\u5236\u5242\u5728\u6ce8\u5c04\u540e72\u5c0f\u65f6\u7684\u751f\u7269\u5206\u5e03\u3002<\/p>\n

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\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aEndogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy<\/a> (J. Am. Chem. Soc.<\/em>, 2020<\/strong>, DOI: 10.1021\/jacs.0c05604)<\/p>\n

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