{"id":208390,"date":"2020-09-01T15:00:37","date_gmt":"2020-09-01T07:00:37","guid":{"rendered":"\/\/m.iemloyee.com\/?p=208390"},"modified":"2020-09-01T11:17:10","modified_gmt":"2020-09-01T03:17:10","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91adv-mater-%e7%bb%bc%e8%bf%b0%ef%bc%9a%e7%94%a8%e4%ba%8e%e5%88%86%e5%ad%90%e7%9b%b8%e4%ba%92%e4%bd%9c%e7%94%a8%e7%9a%84%e5%8a%9f%e8%83%bd%e5%8c%96%e8%82%bd","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=208390","title":{"rendered":"Adv. Mater.\u7efc\u8ff0\uff1a\u7528\u4e8e\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7684\u529f\u80fd\u5316\u80bd-\u91d1\u6742\u5316\u7eb3\u7c73\u6750\u6599\u7684\u5408\u7406\u8bbe\u8ba1"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u301131<\/strong><\/p>\n

\u91d1\u7eb3\u7c73\u7c92\u5b50\uff08AuNPs\uff09\u7531\u4e8e\u5176\u4f18\u5f02\u7684\u5149\u5b66\u6027\u8d28\uff0c\u5728\u751f\u7269\u4f20\u611f\u76f8\u5173\u7684\u53d1\u5c55\u4e2d\u5f97\u5230\u4e86\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u80bd\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u529f\u80fd\u6027\u751f\u7269\u5206\u5b50\uff0c\u6709\u671b\u53d6\u4ee3\u6297\u4f53\u3001\u53d7\u4f53\u548c\u5e95\u7269\u8fdb\u884c\u7279\u5b9a\u7684\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u3002\u80bd\u548cAuNPs\u90fd\u662f\u7a33\u5b9a\u7684\uff0c\u5e76\u4e14\u5bb9\u6613\u5408\u6210\uff0c\u5236\u5907\u6210\u672c\u90fd\u76f8\u5bf9\u8f83\u4f4e\u3002\u56e0\u6b64\uff0c\u57fa\u4e8e\u80bdAuNPs\u7684\u751f\u7269\u7eb3\u7c73\u6280\u672f\u8d8a\u6765\u8d8a\u53d7\u5230\u4eba\u4eec\u7684\u5173\u6ce8\uff0c\u7279\u522b\u662f\u5728\u5206\u5b50\u9776\u5411\u3001\u7ec6\u80de\u6210\u50cf\u3001\u836f\u7269\u4f20\u9012\u548c\u6cbb\u7597\u7b49\u9886\u57df\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u5965\u5730\u5229\u56fd\u5bb6\u6280\u672f\u7814\u7a76\u9662<\/strong>Wolfgang Knoll<\/strong>\u6559\u6388\u3001\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66<\/strong>Bo Liedberg<\/strong>\u6559\u6388\u548c\u6e29\u5dde\u533b\u79d1\u5927\u5b66\u738b\u6bc5\u7814\u7a76\u5458<\/strong>\u7efc\u8ff0\u4e86\u8fd1\u5e74\u6765\u5173\u4e8e\u529f\u80fd\u5316\u80bd-\u91d1\u6742\u5316\u7eb3\u7c73\u6750\u6599\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u3002\u4ee5\u201cRational Design of Functional Peptide-Gold Hybrid Nanomaterials for Molecular Interactions<\/strong>\u201d\u53d1\u8868\u4e8eAdv. Mater.<\/strong>\u671f\u520a\u4e0a\u3002\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u4ece\u80bd\u529f\u80fd\u5316\u7684\u89d2\u5ea6\u5bf9\u80bd-\u91d1\uff08\u4e3b\u8981\u662fAuNPs\uff09\u6742\u5316\u7eb3\u7c73\u6750\u6599\u8fdb\u884c\u7814\u7a76\uff0c\u5e76\u8ba8\u8bba\u4e86\u5176\u5305\u62ec\u751f\u7269\u4f20\u611f\u3001\u7ec6\u80de\u9776\u5411\u3001\u6210\u50cf\u4ee5\u53ca\u6297\u83cc\u9632\u6c61\u6d82\u5c42\u7684\u5f00\u53d1\u7b49\u751f\u7269\u65b9\u9762\u7684\u5e94\u7528\u3002\u4f5c\u8005\u4ecb\u7ecd\u4e86\u8fc7\u53bb25\u5e74\u6765\u80bd-\u91d1\u6742\u5316\u7eb3\u7c73\u6750\u6599\u5e94\u7528\u7684\u53d1\u5c55\uff0c\u4ece\u8457\u540d\u7684DNA-AuNPs\u7ec4\u88c5\uff0c\u5230\u5206\u5b50\u8bc6\u522b\u548c\u7ec4\u88c5\u7684\u80bd-AuNPs\u88ab\u6df1\u5165\u7814\u7a76\u5e76\u5e94\u7528\u4e8e\u5404\u4e2a\u751f\u7269\u533b\u5b66\u9886\u57df\uff0c\u5982\u4f53\u5916\u9176\u5206\u6790\u3001\u7ec6\u80de\u9776\u5411\u76f8\u5173\u5206\u6790\u5982\u7ec6\u80de\u6210\u50cf\u3001\u7ec6\u80de\u7ed3\u5408\u3001\u7a7f\u900f\u548c\u6838\u9776\u5411\u3001\u8111-\u8840\u5c4f\u969c\uff08BBB\uff09\u6613\u4f4d\u548c\u764c\u75c7\u6cbb\u7597\u7b49\u3002\u4f5c\u8005\u8fd8\u4ecb\u7ecd\u4e86\u6700\u8fd1\u7684\u80bd-AuNPs\u7684\u65b0\u529f\u80fd\/\u5e94\u7528\uff0c\u5982\u50ac\u5316\u5242\u3001\u6297\u83cc\u5242\u3001\u8f85\u52a9\u591a\u5149\u5b50\u663e\u5fae\u955c\u548c\u624b\u6027AuNPs\u7ed3\u6784\u7684\u5f62\u6210\u7b49\u7b49\uff0c\u5e76\u4e3a\u8fd9\u4e00\u7814\u7a76\u8bfe\u9898\u63d0\u4f9b\u4e86\u65b0\u7684\u65b9\u5411\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

1<\/strong>\u3001\u5f15\u8a00<\/strong><\/p>\n

\u56fe\u4e00\u3001\u8fd9\u7bc7\u7efc\u8ff0\u7684\u7ed3\u6784\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"\u56fe\u4e8c\u3001\u5728\u8fc7\u53bb<\/strong>25<\/strong>\u5e74\u4e2d\uff0c\u80bd<\/strong>–<\/strong>\u91d1\u7eb3\u7c73\u7c92\u5b50\u5728\u5f00\u53d1\u5e94\u7528\u65b9\u9762\u7684\u91cd\u8981\u5386\u7a0b<\/strong><\/p>\n

\"\"2<\/strong>\u3001\u76f8\u4e92\u4f5c\u7528\u7684\u80bd\u4e0e<\/strong>AuNP<\/strong>\u7ed3\u5408\u7269<\/strong><\/p>\n

2.1<\/strong>\u3001\u529f\u80fd\u5316\u5408\u6210\u80bd<\/strong><\/p>\n

\u56fe\u4e09<\/strong><\/p>\n

\"\"\uff08A\uff09\u4ece\u566c\u83cc\u4f53\u5e93\uff08\u566c\u83cc\u4f53\u8868\u9762\u4e0d\u540c\u989c\u8272\u7684\u591a\u80bd\uff09\u5f00\u59cb\u566c\u83cc\u4f53\u5c55\u793a\u793a\u610f\u56fe\u3002\u63a5\u4e0b\u6765\u7684\u80bd\u9009\u62e9\u662f\u901a\u8fc7\u7ed3\u5408\uff08\u84dd\u8272\uff09\u3001\u6d17\u8131\uff08\u84dd\u8272\u548c\u975e\u7279\u5f02\u6027\u6a59\u8272\uff09\u548c\u6269\u589e\u7684\u5faa\u73af\u6765\u5b8c\u6210\u7684\u3002\u975e\u7279\u5f02\u6027\u80bd\uff08\u6a59\u8272\uff09\u88ab\u591a\u91cd\u9009\u62e9\u5faa\u73af\u8fb9\u7f18\u5316\uff1b<\/p>\n

\uff08B\uff09\u4e0a\u90e8\uff1a\u80bd\u8bbe\u8ba1\uff0c\u7ed3\u5408\u4f4d\u70b9\u6709\u4e00\u4e2a\u8fde\u7eed\u5e8f\u5217\uff08\u7c89\u7ea2\u8272\uff09\u4f5c\u4e3a\u8868\u4f4d\u3002\u4e0b\uff1a\u80bd\u8bbe\u8ba1\uff0c\u4e09\u4e2a\u80bd\u6bb5\uff08\u9ec4\u8272\u3001\u7eff\u8272\u548c\u7ea2\u8272\uff09\u4f4d\u4e8e\u7ed3\u5408\u888b\u4e2d\uff0c\u7531\u5206\u5b50\u652f\u67b6\u8fde\u63a5\uff0c\u4ee5\u6a21\u62df\u5929\u7136\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\uff1b<\/p>\n

\uff08C\uff09\u5355\u58c1\u78b3\u7eb3\u7c73\u7ba1\uff08SWNT\uff09\u7ed3\u5408\u80bd\u7ed3\u6784\u9884\u6d4b\u7684\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u3002<\/p>\n

2.2<\/strong>\u3001\u591a\u80bd\u5bf9<\/strong>AuNPs<\/strong>\u7684\u7a33\u5b9a\u4f5c\u7528<\/strong><\/p>\n

\u56fe\u56db<\/strong><\/p>\n

\"\"\uff08A\uff09\u4e0e\u5176\u4ed6\u4e24\u79cd\u80bd\u76f8\u6bd4\uff0c\u56fa\u5b9a\u5316\u540e\u5177\u6709\u7279\u6b8a\u7a33\u5b9a\u6027\u7684\u4fdd\u62a4\u6027\u4e94\u80bd\uff08CALNN\uff09\u7684\u9009\u62e9\u6027\uff1b<\/p>\n

\uff08B\uff09\u4e92\u8865\u80bd\u6298\u53e0\u8bf1\u5bfc\u7684AuNP\u805a\u96c6\uff1a\u5f02\u6e90\u4e8c\u805a\uff1b<\/p>\n

\uff08C\uff09AuNP\u805a\u96c6\u8bf1\u5bfc\u7684\u80bd\u6298\u53e0\uff1a\u540c\u6e90\u4e8c\u805a\uff1b<\/p>\n

\uff08D\uff09\u529f\u80fd\u5316AuNP\u4f5c\u4e3a\u6a21\u677f\u5c06\u5408\u6210\u80bd\u6298\u53e0\u6210\u03b1\u87ba\u65cb\u7ed3\u6784\u3002<\/p>\n

2.3<\/strong>\u3001\u80bd<\/strong>-AuNP<\/strong>\u7ed3\u5408\u7269\u7684\u53d7\u63a7\u76f8\u4e92\u4f5c\u7528<\/strong><\/p>\n

3<\/strong>\u3001\u57fa\u4e8e\u80bd<\/strong>–<\/strong>\u91d1\u6742\u5316\u7eb3\u7c73\u6750\u6599\u7684\u9776\u5411\u5206\u5b50<\/strong><\/p>\n

3.1<\/strong>\u3001\u80bd<\/strong>–<\/strong>\u91d1\u5e95\u7269\u7528\u4e8e\u9176\u5206\u6790<\/strong><\/p>\n

3.1.1<\/strong>\u3001\u6c34\u89e3\u53cd\u5e94<\/strong><\/p>\n

\u56fe\u4e94<\/strong><\/p>\n

\"\"\uff08A\uff09\u5229\u7528\u8bbe\u8ba1\u7684\u80bd\u548cAuNPs\u6bd4\u8272\u86cb\u767d\u9176\u4f20\u611f\u8fc7\u7a0b\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09\u7528\u8bbe\u8ba1\u7684His6<\/sub>\u672b\u7aef\u80bd\u548c\u91d1\u5c5e\u79bb\u5b50\u8fdb\u884c\u86cb\u767d\u9176\u7fa7\u4fdd\u62a4AuNP\u6bd4\u8272\u5206\u6790\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08C\uff09\u57f9\u517b60\u5206\u949f\u540e\uff0c\u5728\u5b58\u5728\u6216\u4e0d\u5b58\u5728\u954d\u79bb\u5b50\u7684\u60c5\u51b5\u4e0b\uff0c\u542b\u6709\u4e0d\u540c\u80bd\u7684\u6eb6\u6db2\u4e2d\u7684\u7fa7\u57faAuNP\u7167\u7247\uff081:AuNP\uff0c2:AuNP\/His6<\/sub>-pep\uff0c3:AuNP\/His6<\/sub>-pep\/Ni2+<\/sup>\uff0c4:AuNP\/His6<\/sub>-pep-His6<\/sub>\uff0c5:AuNP\/His6<\/sub>-pep-His6<\/sub>\/Ni2+<\/sup>\uff09\uff1b<\/p>\n

\uff08D\uff09\u901a\u8fc7\u86cb\u767d\u6c34\u89e3\u53bb\u9664\u672b\u7aef\u758f\u6c34\u57fa\u56e2\uff0c\u86cb\u767d\u9176\u53ef\u88c2\u89e3\u7684Fmoc\u5269\u4f59\u80bd\u4fee\u9970\u805a\u5408\u7684AuNPs\uff0c\u5176\u518d\u5206\u6563\u7684\u793a\u610f\u56fe\u548c\u76f8\u5e94\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08E\uff09\u8bbe\u8ba1\u7684\u80bd\u7ed3\u6784:1\u3001\u5b8c\u6574\u7684\u70ed\u6eb6\u9176\u80bd\u5e95\u7269\uff0c2\u3001\u88c2\u89e3\u540e\uff1b<\/p>\n

\uff08F\uff09\u6dfb\u52a0\u9176\u524d\uff08\u5b9e\u7ebf\uff09\u548c\u9176\u5b75\u80b26\u5c0f\u65f6\u540e1-AuNPs\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\uff08\u865a\u7ebf\uff09\uff1b<\/p>\n

\uff08G\uff09250\u548c45 ng\u00b7mL\u22121<\/sup>\u70ed\u6eb6\u9176\u80bd\u57285\u5206\u949f\u95f4\u9694\u5185\u7684\u9884\u805a\u96c61-AUNP\uff08\u7528\u0394\u6bd4\u7387A\/D\u8868\u793a\uff09\u7684\u518d\u5206\u6563\u6c34\u5e73\u3002<\/p>\n

\u56fe\u516d<\/strong><\/p>\n

\"\"\uff08A\uff09MMP-7\u5728AuNPs\u4e0a\u88c2\u89e3\u5e95\u7269\u80bd\u8bf1\u5bfc\u7684\u805a\u96c6\u8fc7\u7a0b\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09\u7528MMP-7\u86cb\u767d\u9176\u6d88\u5316\u524d\uff08+\uff0c\u9ed1\u8272\uff09\u548c\u6d88\u5316\u540e\uff08+\uff0c\u7ea2\u8272\uff09\uff0c\u91d1\u8868\u9762\u56fe\u6848\u80bd\u5e95\u7269\u7684\u692d\u5706\u504f\u632f\u5bf9\u6bd4\u56fe\u50cf\uff0c\u5177\u6709\u76f8\u5e94\u7684\u9ad8\u5ea6\u5206\u5e03\uff1b<\/p>\n

\uff08C\uff09\u4f7f\u7528\u4e24\u79cd\u80bd\u8bbe\u8ba1\uff081\u548c2\uff09\u548c\u751f\u7269\u529f\u80fd\u5316AuNPs\u8fdb\u884cBoLcA\u68c0\u6d4b\u7684\u6df7\u5408\u548c\u6865\u63a5\u5206\u6790\uff1b<\/p>\n

\uff08D\uff0cE\uff09\u7528100 nM\u7684BoLcA D\uff09\u548c\u9884\u5b75\u80b2\uff08\u4f5c\u4e3a\u5bf9\u7167\uff09E\uff09\u540e\u7684navi-AuNPs\u548c1-AuNPs\u6df7\u5408\u7269\u6eb6\u6db2\u7684\u5f52\u4e00\u5316\u6d88\u5149\u5149\u8c31\u3002\u63d2\u56fe\u662f\u663e\u793a\u989c\u8272\u53d8\u5316\u7684\u76f8\u5e94AuNP\u6eb6\u6db2\u7684\u7167\u7247\u3002<\/p>\n

\u56fe\u4e03<\/strong><\/p>\n

\"\"\uff08A\uff09\u8367\u5149\u67d3\u6599\u6807\u8bb0\u80bd\u5e95\u7269\u548c\u8868\u9762\u53cd\u5e94\u6027AuNPs\u7ec4\u6210\u4e86\u8367\u5149\u67d3\u6599\u8367\u5149\u63a2\u9488\u7684\u603b\u4f53\u65b9\u6848\uff1b<\/p>\n

\uff08B\uff09\u80bd\u529f\u80fd\u5316AuNP\u548c\u94fe\u9709\u4eb2\u548c\u7d20\u4e4b\u95f4\u80fd\u91cf\u8f6c\u79fb\u7684\u793a\u610f\u56fe-alex488\uff08SA488\uff09\u5728BoLcA\u50ac\u5316\u88c2\u89e3\u4e4b\u524d\uff08\u731d\u706d\uff09\u548c\u4e4b\u540e\uff08\u6062\u590d\uff09\uff1b<\/p>\n

\uff08C\uff09\u7528\u4e0d\u540c\u6d53\u5ea6\u7684BoLcA\uff081 pM\uff0c10 pM\uff0c100 pM\uff0c1 nM\uff0c3 nM\uff0c10 nM\uff09\u548c\u80f0\u86cb\u767d\u9176\uff0810 pM\u548c1 nM\uff09\u9884\u5904\u7406\u76841.4 nM AuNP-pep\u4e0a\uff0cSA488\u7684\u8367\u5149\u5f3a\u5ea6\u968f\u65f6\u95f4\u800c\u53d8\u5316\uff1b<\/p>\n

\uff08D\uff09(C)\u4e2d2\u5c0f\u65f6\u53cd\u5e94\u65f6\u95f4\u5bf9\u5e94\u7684BoLcA\u68c0\u6d4b\u6821\u51c6\u66f2\u7ebf\uff1b<\/p>\n

\uff08E\uff09\u7528AuNP\u80bdQD\u7ed3\u5408\u7269\u68c0\u6d4b\u86cb\u767d\u9176\u539f\u7406\u53ca\u6291\u5236\u5242\u7b5b\u9009\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08F\uff09\u7528\u86cb\u767d\u9176\u7279\u5f02\u6027\u80bd\u5e95\u7269\u4e0eAuNPs\u7ed3\u5408\u7684\u5404\u79cd\u91cf\u5b50\u70b9\uff0c\u5728\u73bb\u7483\u4e0a\u663e\u793a\u5176\u76f8\u5e94\u7684\u989c\u8272\uff08\u7eff\u8272\uff1aMMP-7\uff0c\u7ea2\u8272\uff1acaspase-3\uff0c\u6a59\u8272\uff1a\u51dd\u8840\u9176\uff09\u7684\u590d\u5408\u86cb\u767d\u9176\u5206\u6790\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe\u516b<\/strong><\/p>\n

\"\"\uff08A\uff09\u4ee5\u4e2d\u6027\u4eb2\u548c\u7d20\u5305\u88ab\u7684AuNP\u4e3a\u6838\u5fc3\uff0c\u751f\u7269\u7d20\u5316\u80bdAuNP\u4f5c\u4e3a\u536b\u661f\u7ec4\u6210\u7684\u51a0\u7eb3\u7c73\u9897\u7c92\u63a2\u9488\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09caspase-3\u4ecb\u5bfc\u7684\u51a0\u7eb3\u7c73\u9897\u7c92\u63a2\u9488\u88c2\u89e3\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08C\uff0cD\uff09Caspase-3\u88c2\u89e3\u5bfc\u81f4\u51a0\u7eb3\u7c73\u9897\u7c92\u63a2\u9488\u7684\u5206\u89e3\u8fc7\u7a0b\uff0c\u5982C\uff09\u6563\u5c04\u56fe\u50cf\uff1a\u7ea2\u8272\u5230\u9ec4\u8272\u5230\u6697\u7eff\u8272\u6591\u70b9\uff0c\u4ee5\u53caD\uff09\u5149\u8c31\uff1a\u6700\u521d\u4ece654 nm\uff08\u7ea2\u8272\uff09\u84dd\u79fb\uff1b<\/p>\n

\uff08E\uff09\u9010\u7ea7\u5f3a\u5ea6\u4e0b\u964d\u8868\u660e\u5355\u536b\u661f\u7eb3\u7c73\u9897\u7c92\u5206\u88c2\uff1b<\/p>\n

\uff08F\uff09\u5728\u663e\u5fae\u955c\u56fe\u50cf\u4e2d\uff0c\u660e\u4eae\u7684\u548c\u7ea2\u8272\u7684\u6591\u70b9\u663e\u793a\u7ec6\u80de\u5c06\u51a0\u72b6\u7eb3\u7c73\u9897\u7c92\u63a2\u9488\u901a\u8fc7\u7ec6\u80de\u7a7f\u900f\u80bd(Thr-Ala-Thr)\u9012\u9001\u5230HeLa\u548cSW620\uff1b<\/p>\n

\uff08G\uff09\u5728\u52a0\u5165\u51cb\u4ea1\u8bf1\u5bfc\u5242\uff08TNF-\u03b1\u548cCHX\uff09\u540e\uff0c\u7ec6\u80de\u5185\u7684Caspase-3\u6d3b\u6027\u9010\u6e10\u53d8\u4e3a\u6697\u7ea2\u8272\/\u7eff\u8272\uff0c\u800c\u5728\u6ca1\u6709\u51cb\u4ea1\u8bf1\u5bfc\u5242\u6216\u6dfb\u52a0Caspase-3\u6291\u5236\u5242\uff08z-DEVD-fmk\uff09\u7684\u7ec6\u80de\u4e2d\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u4fe1\u53f7\u53d8\u5316\u3002<\/p>\n

\u56fe\u4e5d<\/strong><\/p>\n

\"\"\uff08A\uff09\u57fa\u4e8e\u8bbe\u8ba1\u7684\u80bd\u5e95\u7269\u548cAuNPs\u7684\u6bd4\u8272\u6cd5ALP\u5206\u6790\u793a\u610f\u56fe\uff0c\u5176\u4e2d\u80bd\u4e2d\u78f7\u9178\u916a\u6c28\u9178\u7684\u8d1f\u7535\u8377\u963b\u6b62AuNP\u805a\u96c6\uff0c\u76f4\u5230ALP\u53bb\u9664\u80bd\u4e0a\u7684\u78f7\u9178\u57fa\u56e2\uff0c\u5bfc\u81f4\u80bd\u6865\u63a5AuNP\u805a\u96c6\uff0c\u7136\u540e\u53d8\u8272\uff1b<\/p>\n

\uff08B\uff09\u78b1\u6027\u78f7\u9178\u9176\u7684\u6bd4\u8272\u5206\u6790\u663e\u793a\uff0c\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u989c\u8272\u4ee5\u5242\u91cf\u4f9d\u8d56\u7684\u901f\u7387\u9010\u6e10\u53d8\u5316\uff1b<\/p>\n

\uff08C\uff09\u901a\u8fc7\u6bd4\u8f83650 nm\u5904\u7684\u5438\u6536\u5f3a\u5ea6\u4e0e\u78b1\u6027\u78f7\u9178\u9176\u6291\u5236\u5242\uff08p-BO\uff09\u6d53\u5ea6\uff0c\u5f97\u5230\u4e86\u57fa\u4e8e\u76f8\u540c\u6bd4\u8272\u7cfb\u7edf\u7684\u78b1\u6027\u78f7\u9178\u9176\u6291\u5236\u8bd5\u9a8c\u7684\u52a8\u529b\u5b66\u66f2\u7ebf\uff1b<\/p>\n

\uff08D\uff09\u57fa\u4e8e\u78f7\u9178\u5316\u4e8c\u80bd\u5b58\u5728\u4e0b\u5408\u6210AuNPs\u7684\u6bd4\u8272ALP\u5206\u6790\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08E\uff09\u7167\u7247\u663e\u793a\u4e86\u5728ALP\u9884\u5904\u7406\u5b58\u5728(+)\u548c\u4e0d\u5b58\u5728(\u2212)\u60c5\u51b5\u4e0b\uff0c\u4e0e\u4e00\u7cfb\u5217\u80bd\u6d53\u5ea6\u5408\u6210\u7684AuNPs\u7684\u989c\u8272\u5dee\u5f02\uff1b<\/p>\n

\uff08F\uff09\u57fa\u4e8e\u8bbe\u8ba1\u7684\u751f\u7269\u7d20\u5316\u4e8c\u7532\u57fa\u5316\u80bd\u5e95\u7269\u548c\u6297\u4e8c\u7532\u57fa\u6297\u4f53\u7684\u4eb2\u548c\u7d20\u5305\u88abAuNPs\u7684\u6bd4\u8272LSD1\u5206\u6790\u793a\u610f\u56fe\u3002<\/p>\n

3.1.2<\/strong>\u3001\u78f7\u9178\u5316\u53cd\u5e94<\/strong><\/p>\n

\u56fe\u5341<\/strong><\/p>\n

\"\"\uff08A\uff09\u751f\u7269\u7d20\u5316\u4e0e\u7ecf\u6fc0\u9176\u4fee\u9970\u7684\u5e95\u7269\u80bd\u78f7\u9178\u5316\u914d\u5bf9\u7684\u793a\u610f\u56fe\uff0c\u5728\u6dfb\u52a0\u4eb2\u548c\u7d20\u5305\u88ab\u7684AuNPs\u540e\u5bfc\u81f4\u968f\u540e\u7684\u805a\u96c6\uff08\u989c\u8272\u53d8\u5316\uff09\uff0c\u800c\u5728\u5b58\u5728\u6fc0\u9176\u6291\u5236\u5242\u7684\u60c5\u51b5\u4e0b\uff0c\u672a\u89c2\u5bdf\u5230\u805a\u96c6\uff08\u7ea2\u8272\u6b8b\u7559\uff09\uff1b<\/p>\n

\uff08B\uff09\u57fa\u4e8eAuNP\u805a\u96c6\u7684\u6bd4\u8272\u6fc0\u9176\u6d3b\u6027\u6d4b\u5b9a\uff1a\u5e26\u6b63\u7535\u7684\u80bd\u5e95\u7269\u5728\u6ca1\u6709\u6fc0\u9176\u7684\u60c5\u51b5\u4e0b\u8bf1\u5bfcAuNP\u805a\u96c6\uff08\u989c\u8272\u53d8\u5316\uff09\uff0c\u800cPKA\u6fc0\u9176\u53cd\u5e94\u540e\uff0c\u7531\u4e8e\u6b63\u7535\u8377\u4e22\u5931\uff0c\u80bd\u4e0d\u518d\u8bf1\u5bfcAuNP\u805a\u96c6\uff1b<\/p>\n

\uff08C\uff09\u6291\u5236\u5242H-89\u5bf9PKA\u6d3b\u6027\u7684\u6291\u5236\u4f5c\u7528\uff1b<\/p>\n

\uff08D\uff09\u57fa\u4e8e\u8bbe\u8ba1\u7684\u80bd\u529f\u80fd\u5316AuNPs\u548c\u6297\u78f7\u9178\u76d0\u6297\u4f53AuNPs\u7684\u6bd4\u8272\u6fc0\u9176\u5206\u6790\u793a\u610f\u56fe\uff1a\u7531\u6fc0\u9176\u5bfc\u81f4AuNP\u6df7\u5408\u7269\u805a\u96c6\u7684\u80bd\u78f7\u9178\u5316\uff1b<\/p>\n

\uff08E\uff09\u5728\u4e0d\u5b58\u5728\u6fc0\u9176\uff08\u6298\u7ebf\uff09\u548cv-Src-\u6fc0\u9176\uff08\u5b9e\u7ebf\uff09\u7684\u60c5\u51b5\u4e0b\u6df7\u5408AuNPs\u6eb6\u6db2\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\u3002\u63d2\u56fe\uff1a\u663e\u793a\u76f8\u5e94AuNPs\u6eb6\u6db2\u7684TEM\u56fe\u50cf\u3002<\/p>\n

\u56fe\u5341\u4e00<\/strong><\/p>\n

\"\"\uff08A\uff09\u57fa\u4e8eRLS\u7684PKA\u53ca\u5176\u6291\u5236\u5206\u6790\u793a\u610f\u56fe\uff1a\u5728PKA\u5b58\u5728\u4e0b\uff0c\u8bbe\u8ba1\u80bd\u5e95\u7269\u7684\u751f\u7269\u7d20\u5316\u548c\u78f7\u9178\u5316\u5bfc\u81f4\u4eb2\u548c\u7d20\u6d82\u5c42\u7684AuNPs\u9644\u7740\uff0c\u7136\u540e\u94f6\u6c89\u79ef\u4ee5\u589e\u5f3aRLS\u4fe1\u53f7\uff1b<\/p>\n

\uff08B\uff09\u57fa\u4e8e\u8bbe\u8ba1\u7684\u80bd\u6a21\u677f\u91d1\u7eb3\u7c73\u56e2\u7c07\u7684\u8367\u5149PTM\u9176\u5206\u6790\u793a\u610f\u56fe\u3002PTM\u4fee\u9970\u7684\u80bd\u5e95\u7269\u4f7f\u8367\u5149\u5171\u8f6d\u7eb3\u7c73\u6750\u6599\u731d\u706d\uff1b<\/p>\n

\uff08C\uff09\u968f\u7740HDAC-1\u6d53\u5ea6\u7684\u589e\u52a0\uff0c\u8367\u5149\u53d1\u5c04\u5149\u8c31\u9010\u6e10\u4e0b\u964d\uff1b<\/p>\n

\uff08D\uff09\u5229\u7528\u8bbe\u8ba1\u7684\u80bd\u529f\u80fd\u5316AuNPs\u8fdb\u884c\u57fa\u4e8e\u8868\u9762\u7535\u8377\u68c0\u6d4b\u7684\u6fc0\u9176\u6d3b\u6027\u6d4b\u5b9a\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08E\uff09AuNPs\u548cAbI1\u6fc0\u9176\u6d53\u5ea6\u7684\u8868\u9762zeta\u7535\u4f4d\u6821\u51c6\u66f2\u7ebf\uff1b<\/p>\n

\uff08F\uff09\u98de\u884c\u65f6\u95f4\u4e8c\u6b21\u79bb\u5b50\u8d28\u8c31\u663e\u793a\uff0c\u6fc0\u9176\u53cd\u5e94\u540e\u80bd\u5e95\u7269\u5206\u5b50\u91cf\u76f4\u63a5\u589e\u52a0\uff0c\u76f8\u5f53\u4e8eHPO3<\/sub>\u5206\u5b50\u91cf\uff0c\u4f34\u968f\u7740\u539f\u59cb\u4fe1\u53f7\u5f3a\u5ea6\u7684\u964d\u4f4e\u3002<\/p>\n

3.2<\/strong>\u3001\u80bd\u7ed3\u5408\u7269\u7528\u4e8e\u751f\u7269\u4f20\u611f\u548c\u7ec6\u80de\u9776\u5411<\/strong><\/p>\n

3.2.1<\/strong>\u3001\u7528\u4e8e\u751f\u7269\u4f20\u611f<\/strong><\/p>\n

\u56fe\u5341\u4e8c<\/strong><\/p>\n

\"\"\uff08A\uff09\u57fa\u4e8e\u6240\u8bbe\u8ba1\u7684\u80bd\u7ed3\u5408\u7269\u529f\u80fd\u5316AuNPs\u7684\u86cb\u767d\u8d28\u5206\u6790\u7269\u68c0\u6d4b\u539f\u7406\u793a\u610f\u56fe\u3002Zn2+\u79bb\u5b50\u8bf1\u5bfc\u7684\u80bd\u6298\u53e0\u5bfc\u81f4\u4e86AuNPs\u7684\u805a\u96c6\uff0c\u800cHCAII\u7b49\u86cb\u767d\u8d28\u5206\u6790\u7269\u7684\u7ed3\u5408\u963b\u6b62\u4e86\u80bd\u7684\u6298\u53e0\u548c\u968f\u540e\u7684\u805a\u96c6\uff1b<\/p>\n

\uff08B\uff0cC\uff09\u5728\u4e0d\u5b58\u5728B\uff09\u548c\u5b58\u5728C\uff09HCAII\u86cb\u767d\u8d28\u7684\u60c5\u51b5\u4e0b\uff0c\u6dfb\u52a010 mM Zn2+<\/sup>\u79bb\u5b50\u540e\uff0c\u4ee52\u5206\u949f\u95f4\u9694\u8bb0\u5f5520\u5206\u949f\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\uff1b<\/p>\n

\uff08D\uff09\u57fa\u4e8e\u80bd\u7c98\u5408\u5242\u548cAuNPs\u7684Ag+<\/sup>\u6bd4\u8272\u68c0\u6d4b\u793a\u610f\u56fe\u3002\u6dfb\u52a0Ag+<\/sup>\u540e\u80bd\u952e\u7684\u6298\u53e0\u8bf1\u5bfcAuNPs\u7684\u805a\u96c6\uff1b<\/p>\n

\uff08E\uff09\u57fa\u4e8e\u80bd\u5b98\u80fd\u5316AuNPs\u7edc\u5408\u6bd4\u8272\u6cd5\u68c0\u6d4b\u91d1\u5c5e\u79bb\u5b50\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08F\uff09\u4e0d\u540c\u529f\u80fd\u6027\u80bd\u5bf9\u91d1\u5c5e\u79bb\u5b50\u7684\u6bd4\u8272\u54cd\u5e94\u3002<\/p>\n

\u56fe\u5341\u4e09<\/strong><\/p>\n

\"\"\uff08A\uff09\u7528\u4e0d\u540c\u5927\u5c0f\u548c\u6d53\u5ea6\u7684\u80bd\u7c98\u5408\u5242\u529f\u80fd\u5316AuNPs\u68c0\u6d4bcTnI\u7684\u793a\u610f\u56fe\u3002\u7b80\u5355\u52a0\u5165\u9776cTnI\u540e\uff0c\u4ee5\u6d53\u5ea6\u4f9d\u8d56\u7684\u65b9\u5f0f\u8bf1\u5bfc\u5feb\u901f\u805a\u96c6\uff1b<\/p>\n

\uff08B\uff09\u9488\u5bf9100 ng mL\u22121<\/sup> cTnI\uff0c\u7ed8\u5236\u4e86\u4e0eAUNP\u4e0d\u540c\u76f8\u5bf9\u8868\u9762\u79ef\uff08\u6bcf\u79cd\u5c3a\u5bf8\u7684\u56db\u79cd\u7a00\u91ca\u56e0\u5b50\uff1a16 nm\uff0c\u9ed1\u8272\u6b63\u65b9\u5f62\uff1b25 nm\uff0c\u7ea2\u8272\u5706\u5708\uff1b36 nm\uff0c\u84dd\u8272\u4e09\u89d2\u5f62\uff09\u7684\u5cf0\u503c\uff08\u8d28\u5fc3\uff09\u504f\u79fb\uff1b<\/p>\n

\uff08C\uff09\u57fa\u4e8e\u80bd\u529f\u80fd\u5316AuNPs\u7684CB[8]\u5206\u5b50\u5b58\u5728\u4e0b\u6bd4\u8272\u68c0\u6d4bFlt-1\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08D\uff09\u542b\u6709\u9776\u75c5\u6bd2\u8868\u4f4d\u3001\u8fde\u63a5\u5b50\uff08GGG\uff09\u548c\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\u7684\u80bd\u7684\u7ebf\u6027\u7ed3\u6784\uff1b<\/p>\n

\uff08E\uff09\u5728\u76f8\u5e94\u7684\u80bd\u57fa\u8868\u4f4d\u5305\u88ab\u7684AuNPs\u6eb6\u6db2\u4e2d\u6dfb\u52a0200 nM\u5355\u514b\u9686\u6297\u4f53\u540e\uff0c\u6bcf\u969410\u5206\u949f\u8bb0\u5f55\u4e00\u6b21\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\uff0c\u8868\u660e\u5b58\u5728\u5927\u91cf\u805a\u96c6\u3002<\/p>\n

\u56fe\u5341\u56db<\/strong><\/p>\n

\"\"\uff08A\uff09\u56fa\u5b9aPEG\u5c42\uff08\u9ed1\u8272\uff09\u548c\u6297\u4f53\uff08\u7eff\u8272\uff09\u540e\uff0c\u88f8\u91d1\uff08\u6a59\u8272\uff09\u7684\u4ee3\u8868\u6027LSPR\u5149\u8c31\uff0c\u4ee5\u53ca\u5916\u663e\u4f53\uff08\u7ea2\u8272\uff09\u7684\u6700\u7ec8\u68c0\u6d4b\uff0c\u5e76\u9644\u6709\u7b80\u5355\u7684\u793a\u610f\u56fe\u3002\u626b\u63cf\u7535\u5b50\u663e\u5fae\u955c\uff08SEM\uff09\u663e\u793a\u4e86\u5916\u663e\u4f53\u4e0e\u91d1\u7eb3\u7c73\u5b54\u7684\u7ed3\u5408\uff1b<\/p>\n

\uff08B\uff09nPLEX\u6cd5\u4e0eELISA\u6cd5\u7684\u654f\u611f\u6027\u6bd4\u8f83\uff0cnPLEX\u6cd5\u6d4b\u5b9a\u4e0d\u540c\u6d53\u5ea6\u5916\u663e\u4f53\u7684\u7ed3\u679c\u4f18\u4e8eELISA\u6cd5\uff1b<\/p>\n

\uff08C\uff09\u57fa\u4e8e\u6297\u83cc\u80bdmagainin I\u53ca\u5176\u7ed3\u6784\uff08\u5f69\u8272\u03b1-\u87ba\u65cb\uff09\u7684\u7ec6\u83cc\u7535\u68c0\u6d4b\u793a\u610f\u56fe\uff0c\u5305\u62ec\u5728\u91d1\u5fae\u7535\u6781\u9635\u5217\u4e0a\u7684\u56fa\u5b9a\u548c\u9776\u83cc\u7684\u7ed3\u5408\uff1b<\/p>\n

\uff08D\uff09\u572810\u8d6b\u5179\u4e0b\u5bf9\u4e0d\u540c\u6d53\u5ea6\u5927\u80a0\u6746\u83cc\u8fdb\u884c\u963b\u6297\u6d4b\u91cf\uff0c\u4f30\u8ba1LOD\u4e3a103 cfu mL\u22121<\/sup>\uff08\u22481\u4e2a\u7ec6\u83cc\/\u03bcL\uff09\uff1b<\/p>\n

\uff08E\uff09\u80bd\u7ed3\u5408\u7269\u7535\u5316\u5b66\u68c0\u6d4b\u8bfa\u5982\u75c5\u6bd2\u7684\u5de5\u4f5c\u6d41\u7a0b\u793a\u610f\u56fe\uff0c\u5305\u62ec\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u7684\u80bd\u9009\u62e9\uff081\uff09\u3001\u80bd\u7ed3\u5408\u7269\uff081-2\uff09\u7684\u8bbe\u8ba1\u548c\u5408\u6210\u3001\u56fa\u5b9a\u5316\uff082-3\uff09\u548c\u8bd5\u9a8c\uff083-4\uff09\u3002<\/p>\n

3.2.2<\/strong>\u3001\u7528\u4e8e\u7ec6\u80de\u9776\u5411\u548c\u540e\u7eed\u5e94\u7528<\/strong><\/p>\n

\u56fe\u5341\u4e94<\/strong><\/p>\n

\"\"\uff08A\uff09\u67f1\u72b6\u56fe\u663e\u793a\u80bd5\uff08ConG\u5e8f\u5217\uff1aGEXXLQXNQXLIRXKSNC\uff0cX:\u03b3-\u7fa7\u8c37\u6c28\u9178\u76d0\uff0c\u672b\u7aefC\u56fa\u5b9a\u5316\uff09\u529f\u80fd\u5316AuNPs\uff08AuNP-5\uff09\u4e0eHEK 293\u7ec6\u80de\u8868\u9762NMDA\u53d7\u4f53\u7684\u9009\u62e9\u6027\u7ed3\u5408\uff1b<\/p>\n

\uff08B\uff09\u4e0e\u7ecfAuNP-6\u5904\u7406\u7684\u7ec6\u80de\uff08\u53f3\uff0c\u51e0\u4e4e\u627e\u4e0d\u5230\uff09\u76f8\u6bd4\uff0cAuNP-5\u4e0e\u8f6c\u67d3\u7ec6\u80de\u9009\u62e9\u6027\u7ed3\u5408\u7684\u626b\u63cf\u7535\u955c\u56fe\u50cf\uff08\u5de6\uff0c\u8bb8\u591a\u4eae\u70b9\uff09\uff1b<\/p>\n

\uff08C\uff09AuNP-5\u4e0e\u8f6c\u67d3\u7ec6\u80de\u7684\u7ed3\u5408\u66f2\u7ebf\u8868\u660e\uff0c\u7531\u4e8e\u591a\u4ef7\u6027\uff0c\u7ed3\u5408\u4eb2\u548c\u529b\u6bd4\u6e38\u79bbConG\u63d0\u9ad8\u4e86\u4e00\u5343\u500d\uff1b<\/p>\n

\uff08D\uff09\u80bd\u529f\u80fd\u5316AuNPs\u9009\u62e9\u6027\u9776\u5411\u7ec6\u80de\u6574\u5408\u7d20GPIIb\/iia\u7528\u4e8e\u6210\u50cf\uff08i\uff09\u548c\u5b9a\u91cf\u6bd4\u8272\u4f20\u611f\uff08ii\uff09\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08E\uff09\u57f9\u517b\u7ec6\u80de\u66b4\u9732\u4e8e120 n M\u80bd-AuNPs\uff08\u7b2c\u4e00\u884c\uff09\u548c\u4f5c\u4e3a\u9634\u6027\u5bf9\u7167\u7684\u5206\u6563\u4ecb\u8d28\uff08\u7b2c\u4e8c\u884c\uff09\u7684\u660e\u573a\uff08\u7b2c\u4e00\u5217\uff09\u548c\u53cc\u5149\u5b50\u8367\u5149\uff08\u7b2c\u4e8c\u5217\uff09\u56fe\u50cf\uff0c\u8868\u660e\u4e86\u8fd9\u79cd\u7eb3\u7c73\u63a2\u9488\u7684\u7279\u5f02\u6027\uff1b<\/p>\n

\uff08F\uff09\u7ebf\u6027\u62df\u5408\u66f2\u7ebf\u5c06\u7ec6\u80de\u6570\u4e0eAuNPs\u6d53\u5ea6\uff08\u7ea2\u8272\uff09\u548c\u8272\u5ea6\u4fe1\u53f7\uff08\u84dd\u8272\uff09\u76f8\u5173\u8054\uff0c\u4ece\u800c\u80fd\u591f\u8ba1\u7b97\u51fa\u6bcf\u4e2a\u7ec6\u80de\u8868\u9762\u4e0a\u6574\u5408\u7d20GPIIb\/iia\u7684\u6570\u91cf\u3002<\/p>\n

\u56fe\u5341\u516d<\/strong><\/p>\n

\"\"\uff08A\uff09\u9776\u5411p32\u8868\u8fbeMDA-MB-435\u7ec6\u80de\u7684\u5929\u7136LyP-1\u80bd\u7684\u5316\u5b66\u7ed3\u6784\uff1b<\/p>\n

\uff08B\uff09LyP-1\u80bd\uff08\u7d2b\u5708\uff09\u901a\u8fc7\u70b9\u51fb\u5316\u5b66\u548c\u9776\u5411\u8868\u8fbe\u53d7\u4f53\uff08\u7ea2\u8272\uff09\u7684azido-PEG\u5305\u88abAuNPs\u4e0a\u7684\u529f\u80fd\u5316\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08C\uff09\u9776\u5411\u764c\u7ec6\u80de\u7684LyP-1-AuNPs\u8367\u5149\u56fe\u50cf\uff08\u53f3\uff09\u663e\u793a\u8fd1\u7ea2\u5916\u8367\u5149\u589e\u5f3a\uff08\u7ea2\u8272\uff09\uff0c\u800c\u53e0\u6c2e-PEG-AuNPs\u4f5c\u4e3a\u5bf9\u7167\uff08\u5de6\uff09\u5219\u6ca1\u6709\u89c2\u5bdf\u5230\u53ef\u68c0\u6d4b\u7684\u4fe1\u53f7\uff1b<\/p>\n

\uff08D\uff09\u542bBSA\u86cb\u767d\u7684\u7279\u5f02\u6027\u6838\u9776\u5411\u80bdAuNPs\u529f\u80fd\u5316\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08F\uff09pHLIP-EuL-AuNPs\u6613\u4f4d\u5230\u7ec6\u80de\u7684\u793a\u610f\u56fe\u3002\u8be5\u673a\u5236\u4e3b\u8981\u662f\u7531\u4e8epHLIP-EuL-AuNPs\u5904\u7406\u7684\u4eba\u8840\u5c0f\u677f\u5728\u8f83\u4f4e\u7684pH\u5bfc\u81f4\u5176pHLIP\u7684\u6784\u8c61\u7531\u65e0\u89c4\u5377\u66f2\u53d8\u4e3a\u87ba\u65cb\uff1b<\/p>\n

\uff08G\uff0cH\uff09\u672a\u5904\u7406G)\u548c\u7ecfpHLIP-EuL-AuNPs\u5904\u7406H)\u7684\u4eba\u8840\u5c0f\u677f\u7684TEM\u56fe\u50cf\u3002\u540e\u8005\u663e\u793a\u7eb3\u7c73\u9897\u7c92\u80fd\u7a7f\u900f\u5404\u79cd\u8840\u5c0f\u677f\u7ed3\u6784\uff0c\u5982\u5c0f\u6ce1\uff08v\uff09\u3001\u5f00\u653e\u5c0f\u7ba1\u7cfb\u7edf\uff08ocs\uff09\u548c\u7ec6\u80de\u8d28\uff08c\uff09\u3002<\/p>\n

\u56fe\u5341\u4e03<\/strong><\/p>\n

\"\"\uff08A\uff09\u80bd\u7684\u8bbe\u8ba1\u548c\u901a\u8fc7\u5185\u541e\u5c0f\u6ce1\u4ece\u8840\u6db2\u5230\u5927\u8111\u7684\u80bd\u8f6c\u79fb\u793a\u610f\u56fe\u3002\u8be5\u80bd\u5305\u542b\u8bc6\u522b\u8f6c\u94c1\u86cb\u767d\u53d7\u4f53\u7684THR\u5e8f\u5217\u548c\u9488\u5bf9\u8111\u5185A\u03b2<\/em>\u805a\u96c6\u7269\u7684LPFFD\u5e8f\u5217\uff1b<\/p>\n

\uff08B\uff09\u5927\u9f20\u8111\u4e2d\u4e0d\u540c\u7684\u91d1\u542b\u91cf\u8868\u660e\uff0c\u4e0e\u5176\u4ed6\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u901a\u8fc7\u8840\u8111\u5c4f\u969c\u4f20\u9012\u7684THR-CLPFFD-AuNPs\u91cf\u6700\u9ad8\uff1b<\/p>\n

\uff08C\uff09\u7528\u4e8e\u6cbb\u7597\u548c\u8bca\u65ad\u76ee\u7684\u7684TAT-AuNPs\u6ce8\u5165\u8111\u80bf\u7624\u7684\u793a\u610f\u56fe\u3002\u6cbb\u7597\u836f\u7269\uff08Dox\uff09\u901a\u8fc7pH\u654f\u611f\u8fde\u63a5\u7269\uff08\u5de6\u4e0a\uff09\u4e0eTAT-AuNPs\u8fde\u63a5\uff1bMRI\u9020\u5f71\u5242\uff08Gd3+\uff09\u87af\u5408\u5728TAT-AuNPs\u4e0a\uff0c\u6700\u7ec8\u5728\u80bf\u7624\u7ec6\u80de\uff08\u53f3\u4e0a\uff09\u4e2d\u79ef\u805a\uff1b<\/p>\n

\uff08D\uff09\u6ce8\u5c04Dox-TAT-AuNPs\u540e\uff0c\u7528H&E\uff08\u7ec4\u7ec7\u7ed3\u6784\uff09\u548c\u94f6\u589e\u5f3a\uff08AuNPs\uff09\u67d3\u8272\u7684\u5c0f\u9f20\u8111\u7ec4\u7ec7\u7684\u663e\u5fae\u56fe\u50cf\uff0c\u663e\u793a\u7eb3\u7c73\u9897\u7c92\u5728\u80bf\u7624\u4e0a\u7684\u5b9a\u4f4d\uff1b<\/p>\n

\uff08E\uff09\u9885\u5185\u80bf\u7624\u8377\u7624\u5c0f\u9f20\u9759\u8109\u6ce8\u5c04Dox-TAT-AuNPs\uff08red\uff09\u540e\u7684Kaplan-Meier\u751f\u5b58\u66f2\u7ebf\u4e0e\u76f8\u540c\u5242\u91cfDox\u7684\u5176\u4ed6\u5bf9\u7167\u7ec4\u6bd4\u8f83\uff1b<\/p>\n

\uff08F\uff09Gd3+<\/sup>-TAT-AuNPs\u6ce8\u5c0424\u5c0f\u65f6\u540e\u8377\u7624\u5c0f\u9f20\u7684T2\u52a0\u6743MRI\u6c34\u5e73\u5207\u7247\uff08\u7ea2\u8272\u865a\u7ebf\u5706\u5708\uff1a\u80bf\u7624\u7ec4\u7ec7\uff09\uff1b<\/p>\n

\uff08G\u3001H\uff09\u76f8\u540c\u6cbb\u7597\u65b9\u6cd5\u7684\u8377\u7624\u5c0f\u9f20\u7684\u7ec4\u7ec7\u5b66\u7814\u7a76\u3002\u8111\u7ec4\u7ec7\u7ecfH&E\u548c\u94f6\u589e\u5f3a\u67d3\u8272\uff08\u9ed1\u70b9\uff1a\u589e\u5f3aAuNPs\uff09\uff1b<\/p>\n

\uff08J\uff09BBB\u6e17\u900f\u6027Angioppe2\u80bd\u529f\u80fd\u5316\u5bf9\u9178\u654f\u611f\u7684AuNPs\u793a\u610f\u56fe\u3002\u751f\u7406\u9178\u6027\u6761\u4ef6\u4e0b\u89e6\u53d1PEG\u5c42\u8131\u819c\u540e\uff0c\u4e24\u79cd\u7eb3\u7c73\u7c92\uff08\u53e0\u6c2e-\u548c\u7094\u57fa-\uff09\u901a\u8fc7\u70b9\u51fb\u5316\u5b66\u805a\u96c6\uff0c\u6700\u7ec8\u5728\u8111\u80bf\u7624\u7ec4\u7ec7\u4e2d\u79ef\u805a\uff1b<\/p>\n

\uff08K\uff09\u5728\u6ce8\u5c04\u6df7\u5408\u529f\u80fd\u6027AuNPs\u4e4b\u524d\u30011\u5c0f\u65f6\u548c24\u5c0f\u65f6\u540e\uff0c\u79fb\u690d\u7624\u5c0f\u9f20\u7684\u8111T1\u52a0\u6743MRI\uff0c\u663e\u793a\u7531\u4e8e\u7eb3\u7c73\u9897\u7c92\u5728\u80f6\u8d28\u7624\u8fb9\u7f18\u79ef\u805a\uff0c\u4fe1\u53f7\u589e\u5f3a\uff08\u9ec4\u8272\u7bad\u5934\uff09\uff1b<\/p>\n

\uff08M\uff09\u6ce8\u5c04\u6df7\u5408\u529f\u80fdAuNPs\u540e24\u5c0f\u65f6\u80f6\u8d28\u7624\u8111\u7ec4\u7ec7\u7684\u7ec4\u7ec7\u5b66\u548c\u62c9\u66fc\u5149\u8c31\u56fe\u50cf\uff1a\u865a\u7ebf\u4ee5\u4e0a\u533a\u57df\u3002<\/p>\n

4<\/strong>\u3001\u80bd<\/strong>–<\/strong>\u91d1\u6742\u5316\u7eb3\u7c73\u6750\u6599\u7684\u5176\u4ed6\u5e94\u7528<\/strong><\/p>\n

4.1<\/strong>\u3001<\/strong>\u6297\u83cc\u6d3b\u6027<\/strong><\/p>\n

\u56fe\u5341\u516b<\/strong><\/p>\n

\"\"\uff08A\uff09\u4e07\u53e4\u9709\u7d20\u7ed3\u5408AuNP\u4e0eVRE\u83cc\u682a\u4e4b\u95f4\u591a\u4ef7\u76f8\u4e92\u4f5c\u7528\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09\u4e07\u53e4\u9709\u7d20\u5b9a\u5411\u5408\u6210AuNPs\u7684\u53cd\u5e94\u673a\u7406\uff1b<\/p>\n

\uff08C\uff09\u5728\u4e0d\u540c\u5b9e\u9a8c\u6761\u4ef6\u4e0b\uff0c\u5728CM-SH\u548cCM\u80bd\u5b58\u5728\u4e0b\u5408\u6210AuNPs\uff1b<\/p>\n

\uff08D\uff09\u901a\u8fc7\u78b3\u4e8c\u4e9a\u80fa\u5316\u5b66\u5c061018K6\u80bd\u4e0e\u805a\u5408\u7269AuNPs\u5076\u8054\uff1b<\/p>\n

\uff08E\uff09\u6297\u83cc\u80bd\u5076\u8054\u9633\u79bb\u5b50AuNPs\u7684\u5236\u5907\u53ca\u5176\u4e0epDNAs\u548c\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u7684\u793a\u610f\u56fe\u3002<\/p>\n

4.2<\/strong>\u3001\u9632\u6c61\u6027\u80fd<\/strong><\/p>\n

\u56fe\u5341\u4e5d<\/strong><\/p>\n

\"\"\uff08A\uff09\u5305\u542b\u5206\u5b50\u8bc6\u522b\u90e8\u5206\uff08RGD\uff0c\u7d2b\u8272\uff09\u3001\u8d85\u4f4e\u6c61\u67d3\u90e8\u5206\uff08EK repeats\uff0c\u84dd\u8272\uff09\u548c\u8868\u9762\u951a\u5b9a\u90e8\u5206\uff08PPPPC\uff0c\u7eff\u8272\uff09\u7684\u81ea\u7ec4\u88c5\u5355\u5206\u5b50\u819c\u7684\u80bd\u5e8f\u5217\uff1b<\/p>\n

\uff08B\uff09\u7528\u8868\u9762\u7b49\u79bb\u5b50\u4f53\u5171\u632f\u6cd5\uff08SPR\uff09\u6d4b\u8bd5\u4e86\u5728\u9632\u6c61\u80bd\uff08\u542b\u6709EK\u91cd\u590d\u5e8f\u5217\u548cPPPPC\u4f5c\u4e3a\u8fde\u63a5\u5242\u7684\u80bd\uff09\u8868\u9762\u6d3b\u6027\u5242\uff08SAM\uff09\u4e0a\u7684\u86cb\u767d\u8d28\u5438\u9644\uff0c\u7ea4\u7ef4\u86cb\u767d\u539f\uff08\u9ed1\u8272\uff09\u548c\u6eb6\u83cc\u9176\uff08\u767d\u8272\uff09\u7684\u8868\u9762\u6d3b\u6027\u5242\uff08SAM\uff09\u4e0e\u5176\u4ed6\u4e24\u79cd\u76f8\u6bd4\u51e0\u4e4e\u6ca1\u6709\u9644\u7740;<\/p>\n

\uff08C\uff09\u7ec6\u80de\u7c98\u9644\u56fe\u50cf\u663e\u793a\uff0c\u968f\u7740RGD\u80bd\u767e\u5206\u6bd4\u7684\u589e\u52a0\uff08\u4ece0%\u589e\u52a0\u5230100%\uff09\uff0c\u5728\u80bd\u5355\u5c42\u4e0a\u57f9\u517b\u7684\u7ec6\u80de\u5bc6\u5ea6\u589e\u52a0\uff1b<\/p>\n

\uff08D\uff09\u5def\u57fa\u5316\u4e24\u6027\u79bb\u5b50\u80bd\u5728\u91d1\u8868\u9762\u81ea\u7ec4\u88c5\u8fc7\u7a0b\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08E\uff0cF\uff09\u975e\u7279\u5f02\u6027\u86cb\u767d\u8d28\u7ed3\u5408\u5728\u4e24\u6027\u80bd\u548c\u4e24\u4eb2\/\u975e\u79bb\u5b50\u80bd\u4e0a\uff0c\u5206\u522b\u4e0e\u7b80\u5355\u6eb6\u6db2\uff08E\uff09\u548c\u5929\u7136\u590d\u5408\u6eb6\u6db2\uff08F\uff09\u7ed3\u5408\u3002\u4e24\u6027\u80bd\uff08\u767d\u8272\uff09\u6bd4\u4e24\u4eb2\u6027\/\u975e\u79bb\u5b50\u80bd\uff08\u9ed1\u8272\uff09\u5177\u6709\u66f4\u597d\u7684\u9632\u6c61\u6027\u80fd\uff1b<\/p>\n

\uff08G\uff09\u7528His\uff08No:1-3\uff09\u81ea\u7ec4\u88c5\u5230\u5e26\u6b63\u7535\u8377\u7684AuNPs\u4e0a\u7684\u8bbe\u8ba1\u80bd\u7684\u793a\u610f\u56fe\uff0c\u8fd9\u4f7f\u5f97\u5229\u7528\u5e95\u7269Cbz-Phe-ONP\u50ac\u5316\u916f\u4ea4\u6362\u53cd\u5e94\uff1b<\/p>\n

\uff08H\uff09\u7531Zn2+<\/sup>\u79bb\u5b50\u89e6\u53d1\u7684\u5206\u6563\u548c\u805a\u96c6JR2EC AuNPs\u7684\u793a\u610f\u56fe\uff08\u4e0a\uff09\u53ca\u5176\u5728\u591a\u5149\u5b50\u6fc0\u5149\u626b\u63cf\u663e\u5fae\u955c\u4e2d\u7684\u53ef\u89c6\u5316\uff08\u4e0b\uff09\u3002<\/p>\n

4.3<\/strong>\u3001\u5176\u4ed6\u7c7b\u578b\u7684\u529f\u80fd\u80bd<\/strong><\/p>\n

5<\/strong>\u3001\u672a\u6765\u7684\u6311\u6218\u4e0e\u673a\u9047<\/strong><\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u603b\u7ed3\u4e86\u8fd1\u4e9b\u5e74\u7528\u4e8e\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7684\u529f\u80fd\u5316\u80bd-\u91d1\u6742\u5316\u7eb3\u7c73\u6750\u6599\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u3002\u4f5c\u8005\u8ba4\u4e3a\uff0c\u5229\u7528\u80bd-\u91d1\u7eb3\u7c73\u5171\u8f6d\u7269\u5bf9\u6297\u65b0\u578b\u9776\u6807\u6765\u5b9e\u73b0\u65b0\u7684\u4f20\u611f\/\u9776\u5411\u7b56\u7565\u662f\u975e\u5e38\u5177\u6709\u6311\u6218\u6027\u7684\u3002\u5c3d\u7ba1\u76ee\u524d\u5df2\u7ecf\u5f00\u53d1\u4e86\u8bb8\u591a\u57fa\u4e8e\u80bd-AuNP\u7684\u5206\u6790\u65b9\u6cd5\uff0c\u4f46\u5927\u591a\u6570\u65b9\u6cd5\u53ea\u4e0e\u4e00\u5c0f\u90e8\u5206\u9776\u70b9\u53d1\u751f\u5197\u4f59\u4f5c\u7528\u3002\u6bd4\u5982\u5927\u591a\u6570\u9176\u53cd\u5e94\u5076\u8054\u7269\u53ea\u9488\u5bf9\u4e00\u4e9b\u50ac\u5316\u53cd\u5e94\uff1a\u86cb\u767d\u8d28\u6c34\u89e3\u548c\uff08de\uff09\u78f7\u9178\u5316\u3002\u4f46\u968f\u7740\u8bb8\u591a\u5728\u7279\u5b9a\u75c5\u7406\u8fc7\u7a0b\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u7684\u5176\u4ed6\u9176\u7684\u68c0\u6d4b\u5df2\u7ecf\u5229\u7528\u80bd-AuNPs\u53d1\u5c55\u8d77\u6765\u3002\u4f5c\u8005\u8ba4\u4e3a\u5229\u7528\u7279\u5b9a\u8bbe\u8ba1\u7684\u80bd\u6216\u80bd\u8f85\u52a9\u7ec4\u88c5\u624b\u6027\u7ed3\u6784\u7684AuNPs\uff08\u624b\u6027\u7b49\u79bb\u5b50\u4f53\u5149\u5b50\u5b66\uff09\u68c0\u6d4b\/\u7b5b\u9009\u624b\u6027\u5206\u5b50\/\u836f\u7269\u7684\u673a\u4f1a\u4ecd\u7136\u5b58\u5728\u3002\u4f5c\u8005\u6307\u660e\uff0c\u5177\u6709\u8bbe\u8ba1\u6784\u8c61\u7684\u80bd\u53ef\u80fd\u4e3a\u624b\u6027\u5206\u5b50\u7684\u5bf9\u6620\u9009\u62e9\u6027\u68c0\u6d4b\u6216\u5206\u79bb\u63d0\u4f9b\u9ad8\u4eb2\u548c\u529b\u4ee5\u8bbe\u8ba1\u529f\u80fd\u80bd\u3002\u6b64\u5916\uff0c\u53ef\u4ee5\u4ece\u8fd9\u4e9b\u6e29\u548c\u80bd\u4e2d\u8bbe\u8ba1\u51fa\u5408\u9002\u7684\u80bd\u9635\u5217\uff0c\u5e76\u5c06\u5176\u4f5c\u4e3a\u4e00\u4e2a\u529f\u80fd\u5355\u5143\u6765\u5229\u7528\uff0c\u4ece\u800c\u6a21\u62df\u4f20\u611f\u3002\u800c\u5728\u53e6\u4e00\u65b9\u9762\uff0c\u63d0\u9ad8\u80bd-AuNPs\u57fa\u4f20\u611f\u5668\u7684\u654f\u611f\u5ea6\u4e5f\u662f\u4e00\u4e2a\u6781\u4e3a\u91cd\u8981\u7684\u53d1\u5c55\u65b9\u5411\u3002\u8fd9\u53ef\u4ee5\u901a\u8fc7\u6539\u53d8AuNPs\u7684\u5f62\u72b6\u6216\u6784\u5efa\u65b0\u7684\u7eb3\u7c73\u7ec4\u88c5\u4f53\u4ee5\u76d1\u6d4b\u5468\u56f4\u73af\u5883\u5c40\u90e8\u6298\u5c04\u7387\u7684\u5fae\u5c0f\u53d8\u5316\uff0c\u4ee5\u53ca\u4f7f\u7528\u80bd-AuNPs\u7684FRET\u7b56\u7565\u3001\u4e0e\u7535\u5316\u5b66\u6216\u8005\u62c9\u66fc\u5149\u8c31\u7b49\u7ec4\u5408\u65b9\u6cd5\u7528\u4e8e\u63d0\u9ad8\u5404\u79cd\u68c0\u6d4b\u7684\u7075\u654f\u5ea6\u3002\u6700\u540e\uff0c\u4f5c\u8005\u8ba4\u4e3a\u5c06\u529f\u80fd\u6027\u80bd-AuNP\u7ed3\u5408\u7269\u5e94\u7528\u4e8e\u73b0\u573a\u8bd5\u9a8c\u6216\u4e34\u5e8a\u8bca\u65ad\/\u6210\u50cf\u548c\u6cbb\u7597\u662f\u53e6\u4e00\u4e2a\u6781\u5177\u6311\u6218\u6027\u7684\u7814\u7a76\u65b9\u5411\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u751f\u7269\u4f20\u611f\u5de5\u4f5c\u4ecd\u7136\u5c40\u9650\u4e8e\u76f8\u5bf9\u6e05\u6d01\u7684\u6c34\u73af\u5883\u4e2d\u3002\u8fd9\u5bf9\u9776\u5206\u5b50\u5177\u6709\u6e29\u548c\u4eb2\u548c\u529b\u7684\u80bd\u53d7\u4f53\u53ef\u80fd\u9002\u7528\u4e8e\u9700\u8981\u81ea\u53d1\u53ef\u9006\u7ed3\u5408\u7684\u5b9e\u65f6\u4e34\u5e8a\u76d1\u6d4b\uff0c\u540c\u65f6\u8fd8\u8981\u6709\u4f53\u5185\u6bd2\u7406\u6027\u65b9\u9762\u5f71\u54cd\u7684\u8003\u8651\u3002\u6b64\u5916\uff0c\u80bd-AuNPs\u7684\u5b9e\u9645\u5e94\u7528\u8fd8\u9700\u8003\u8651\u5230\u7b80\u5355\u6027\u3001\u6210\u672c\u548c\u751f\u6001\u6548\u7387\u7b49\u65b9\u9762\u56e0\u7d20\u3002\u603b\u4e4b\uff0c\u529f\u80fd\u6027\u80bd\u91d1\u7eb3\u7c73\u6750\u6599\u5df2\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u9776\u5411\u6027\u5e94\u7528\uff0c\u4f5c\u8005\u9884\u8ba1\u65b0\u7684\u80bd\u8bbe\u8ba1\u548c\u7eb3\u7c73\u6280\u672f\u5c06\u4e3a\u672a\u6765\u5728\u751f\u7269\u533b\u5b66\u9886\u57df\u548c\u5176\u4ed6\u9886\u57df\u7684\u5e94\u7528\u94fa\u5e73\u9053\u8def\u3002\u4f5c\u8005\u8ba4\u4e3a\uff0c\u9762\u5bf9\u9ad8\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u89e3\u51b3\u771f\u5b9e\/\u4e34\u5e8a\u6837\u672c\u68c0\u6d4b\u7684\u6311\u6218\uff0c\u7ec6\u80de\u9776\u5411\/\u6210\u50cf\u548c\u533b\u5b66\u6cbb\u7597\u5c06\u662f\u533b\u5b66\u3001\u751f\u7269\u5de5\u7a0b\u3001\u8868\u9762\u548c\u6750\u6599\u79d1\u5b66\u754c\u957f\u671f\u9700\u8981\u89e3\u51b3\u7684\u95ee\u9898\uff0c\u800c\u80bd-AuNPs\u5219\u6709\u671b\u4e3a\u5176\u53d1\u5c55\u63d0\u4f9b\u4e00\u4e2a\u7406\u60f3\u7684\u6280\u672f\u5e73\u53f0\u3002<\/p>\n

 <\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aRational Design of Functional Peptide\u2010Gold Hybrid Nanomaterials for Molecular Interactions<\/a>\uff08Adv. Mater.<\/em> 2020<\/strong>, 2000866.\uff09<\/p>\n

 <\/p>\n

\u3010\u738b\u6bc5\u6559\u6388\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u6e29\u5dde\u533b\u79d1\u5927\u5b66<\/strong>\u773c\u89c6\u5149\u5b66\u9662\u3001\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u9662\u6559\u6388\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5927\u5b66\u6e29\u5dde\u7814\u7a76\u9662<\/strong>\u7814\u7a76\u5458\uff0c\u6d59\u6c5f\u7701\u6d77\u5916\u9ad8\u5c42\u6b21\u4eba\u624d\u8ba1\u5212\u7279\u8058\u4e13\u5bb6\u30022010\u5e74\u83b7\u5fb7\u56fd\u7f8e\u56e0\u8328\u5927\u5b66\u3001\u5fb7\u56fd\u9a6c\u666e\u9ad8\u5206\u5b50\u6240\u535a\u58eb\u5b66\u4f4d\u3002\u4e4b\u540e\u5728\u5965\u5730\u5229\u56fd\u5bb6\u6280\u672f\u7814\u7a76\u9662\u3001\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u4ece\u4e8b\u79d1\u7814\u5de5\u4f5c\u3002\u8fd1\u5e74\u6765\uff0c\u56e2\u961f\u4e3b\u8981\u5728SPR\u548c\u62c9\u66fc\u4f20\u611f\u5668\u7684\u5f00\u53d1\u3001\u751f\u7269\u548c\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7b49\u751f\u7269\u5316\u5b66\u4f20\u611f\u5668\u65b9\u9762\u5f00\u5c55\u7814\u7a76\u5de5\u4f5c\uff0c\u5e94\u7528\u4e8e\u4e34\u5e8a\u80bf\u7624\u8bca\u65ad\u3001\u795e\u7ecf\u7ec4\u7ec7\u6210\u50cf\u7b49\u3002\u73b0\u4e3b\u6301\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u9879\u76ee\uff08\u8bfe\u9898\uff09\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u6d59\u6c5f\u7701\u6770\u51fa\u9752\u5e74\u79d1\u5b66\u57fa\u91d1\u7b49\u9879\u76ee\u3002\u622a\u6b62\u76ee\u524d\u5728Advanced Materials, Chemical Science, Analytical Chemistry, Biosensors and Bioelectronics\u7b49\u671f\u520a\u53d1\u8868SCI\u8bba\u658750<\/strong>\u4f59\u7bc7\uff0cH\u6307\u657026<\/strong>\uff0c\u82f1\u6587\u8457\u4f5c3\u90e8\uff0c\u7533\u8bf7\u53d1\u660e\u4e13\u522915<\/strong>\u9879\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u738b\u6bc5\u56e2\u961f\u4e0e\u5176\u5408\u4f5c\u8005\u5229\u7528\u591a\u80bd–<\/span>\u91d1\u7eb3\u7c73\u9897\u7c92\u6df7\u5408\u6750\u6599\u5728\u751f\u7269\u4f20\u611f\u9886\u57df\u8fdb\u884c\u4e86\u7cfb\u5217\u7684\u7814\u7a76\uff0c\u5305\u62ec\uff1a\u901a\u8fc7\u81ea\u884c\u8bbe\u8ba1\u7684\u591a\u80bd\u5e95\u7269\u7ed3\u5408\u91d1\u7eb3\u7c73\u9897\u7c92\u8fdb\u884c\u795e\u7ecf\u6bd2\u7d20\u7684\u6bd4\u8272\u6cd5\u548c\u8367\u5149\u6dec\u706d\u6cd5\u68c0\u6d4b\uff08Analytical Chemistry<\/em>, 2014<\/strong>, 86,\u00a02345-2352<\/span>\uff1bChem Sci<\/em>, 2014<\/strong>, 5,\u00a02651-2656.<\/span>\uff09\uff0c\u603b\u7ed3\u4e86\u7531\u4e0d\u540c\u5f62\u72b6\u3001\u5927\u5c0f\u7b49\u91d1\u7eb3\u7c73\u9897\u7c92\u8fdb\u884c\u8089\u773c\u53ef\u8bc6\u522b\u6bd4\u8272\u6cd5\u7684\u89c4\u5f8b\uff08Analytical Chemistry<\/em>, 2018<\/strong>, 90: 4916\u20134924.<\/span>\uff09\uff0c\u5229\u7528\u7b5b\u9009\u51fa\u7684\u591a\u80bd\u7ed3\u5408\u5206\u5b50\u4fee\u9970\u7684\u91d1\u7eb3\u7c73\u9897\u7c92\u8fdb\u884c\u5fc3\u808c\u808c\u9499\u86cb\u767d\u7684\u6bd4\u8272\u6cd5\u548c\u7535\u5316\u5b66\u68c0\u6d4b\uff0c\u5e76\u7ec6\u81f4\u5206\u6790\u4e86\u7eb3\u7c73\u9897\u7c92\u7684\u5927\u5c0f\u548c\u6d53\u5ea6\uff0c\u4ee5\u53ca\u5916\u52a0\u7535\u538b\u5bf9\u68c0\u6d4b\u9650\u7684\u5f71\u54cd\uff08Analytical Chemistry<\/em>, 2016<\/strong>, 88,\u00a011924-11930; ACS Sensors<\/em>, 2016<\/strong>, 1,\u00a01416-1422<\/span>\uff1bNanoscale<\/em> 2015<\/strong>, 7,\u00a017244-17248.<\/span>\uff09\uff0c\u540c\u65f6\u5229\u7528\u4e86\u667a\u80fd\u624b\u673a\u4f5c\u4e3a\u5149\u8c31\u68c0\u6d4b\u5e73\u53f0\u8fdb\u884c\u4fbf\u643a\u68c0\u6d4b\uff08Biosensors and Bioelectronics<\/em> 2018<\/strong>, 99, 312-317<\/span>\uff1bAnalyst<\/em>, 2016<\/strong>, 11,\u00a03233-3238.<\/span>\uff09\u3002<\/p>\n

 <\/p>\n

\u672c\u6587\u7531\u6211\u4ea6\u662f\u884c\u4eba\u7f16\u8bd1\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/a><\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u301131 \u91d1\u7eb3\u7c73\u7c92\u5b50\uff08AuNPs\uff09\u7531\u4e8e\u5176\u4f18\u5f02\u7684\u5149\u5b66\u6027\u8d28\uff0c\u5728\u751f\u7269\u4f20\u611f\u76f8\u5173\u7684\u53d1\u5c55\u4e2d\u5f97\u5230\u4e86\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u80bd\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u529f\u80fd\u6027\u751f\u7269\u5206\u5b50\uff0c\u6709\u671b\u53d6\u4ee3\u6297\u4f53\u3001\u53d7\u4f53\u548c\u5e95\u7269…<\/p>\n","protected":false},"author":11455,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[533],"tags":[4460],"class_list":["post-208390","post","type-post","status-publish","format-standard","hentry","category-zongshu","tag-4460"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/208390"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/11455"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=208390"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/208390\/revisions"}],"predecessor-version":[{"id":208439,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/208390\/revisions\/208439"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=208390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=208390"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=208390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}