{"id":207155,"date":"2020-08-25T06:30:42","date_gmt":"2020-08-24T22:30:42","guid":{"rendered":"\/\/m.iemloyee.com\/?p=207155"},"modified":"2020-08-24T20:37:36","modified_gmt":"2020-08-24T12:37:36","slug":"%e6%be%b3%e5%a4%a7%e5%88%a9%e4%ba%9a%e6%98%86%e5%a3%ab%e5%85%b0%e5%a4%a7%e5%ad%a6%e4%bd%99%e6%89%bf%e5%bf%a0acc-chem-res-%ef%bc%9a%e7%94%a8%e4%ba%8e%e7%94%9f%e7%89%a9%e5%8c%bb%e5%ad%a6%e7%9a%84","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=207155","title":{"rendered":"\u6fb3\u5927\u5229\u4e9a\u6606\u58eb\u5170\u5927\u5b66\u4f59\u627f\u5fe0Acc. Chem. Res.\uff1a\u7528\u4e8e\u751f\u7269\u533b\u5b66\u7684\u4e8c\u6c27\u5316\u7845\u57fa\u7eb3\u7c73\u9897\u7c92\uff1a\u4ece\u7eb3\u7c73\u8f7d\u4f53\u5230\u751f\u7269\u529f\u80fd\u8c03\u8282\u5242"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

\u4e8c\u6c27\u5316\u7845\u57fa\u7eb3\u7c73\u7c92\u5b50\uff08SNP\uff09\u662f\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u4e00\u7c7b\u7ecf\u5178\u6750\u6599\uff0c\u5177\u6709\u51fa\u8272\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u53ef\u5b9a\u5236\u7684\u7406\u5316\u7279\u6027\u3002SNP\u901a\u5e38\u88ab\u8bbe\u8ba1\u4e3a\u7eb3\u7c73\u8f7d\u4f53\uff0c\u7528\u4e8e\u9012\u9001\u4e0d\u540c\u836f\u7269\u5206\u5b50\u3002\u4e3a\u4e86\u63d0\u9ad8\u9012\u9001\u6548\u7387\u548c\u7597\u6548\uff0c\u7814\u7a76\u8005\u7cbe\u5fc3\u8bbe\u8ba1\u4e86\u4e0d\u540c\u7684SNP\uff0c\u5305\u62ec\u8c03\u63a7\u5176\u7c92\u5f84\uff0c\u5f62\u8c8c\u548c\u4ecb\u89c2\u7ed3\u6784\uff0c\u4fee\u9970\u9776\u5411\u914d\u4f53\u548c\u201c\u5b88\u95e8\u4eba\u201d\u4ee5\u63d0\u9ad8\u7ec6\u80de\u9009\u62e9\u6027\u53ca\u836f\u7269\u7684\u6309\u9700\u91ca\u653e\u3002\u503c\u5f97\u6307\u51fa\u7684\u662f\uff0c\u7eaf\u4e8c\u6c27\u5316\u7845\u9aa8\u67b6\u7684\u751f\u7269\u5b66\u60f0\u6027\u8f83\u5927\u5730\u9650\u5236\u4e86SNP\u7684\u529f\u80fd\uff0c\u4f7f\u5f97\u5e38\u89c4SNP\u4e3b\u8981\u4f5c\u4e3a\u7eb3\u7c73\u8f7d\u4f53\u7528\u4e8e\u9776\u5411\u548c\u63a7\u91ca\u3002\u65b0\u4e00\u4ee3\u7eb3\u7c73\u836f\u7269\u9700\u8981\u66f4\u9ad8\u7684\u529f\u6548\u548c\u7cbe\u5ea6\uff0c\u56e0\u800c\u6df1\u5165\u8ba4\u8bc6SNP\u7684\u7406\u5316\u6027\u8d28\u4e0e\u5176\u751f\u7269\u5b66\u529f\u80fd\u4e4b\u95f4\u7684\u6784\u6548\u5173\u7cfb\uff0c\u5b9e\u73b0\u4ece\u7b80\u5355\u7684\u65f6\u7a7a\u63a7\u5236\u673a\u5236\u5411\u66f4\u590d\u6742\u7684\u751f\u7269\u5316\u5b66\u529f\u80fd\u548c\u4fe1\u53f7\u4f20\u5bfc\u901a\u8def\u7684\u8c03\u8282\u5177\u6709\u91cd\u8981\u7684\u79d1\u5b66\u4ef7\u503c\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u8fd9\u7bc7\u7efc\u8ff0\u91cd\u70b9\u4ecb\u7ecd\u4e86\u7528\u4e8e\u751f\u7269\u533b\u5b66\u5e94\u7528\u7684SNP\u7814\u7a76\u7684\u6700\u65b0\u8fdb\u5c55\u3002\u4f5c\u8005\u9996\u5148\u8ba8\u8bba\u4e86\u5982\u4f55\u901a\u8fc7\u5bf9\u8868\u9762\u62d3\u6251\uff0c\u7ed3\u6784\u5bf9\u79f0\u6027\u548c\u5b54\u7ed3\u6784\u7684\u7cbe\u7ec6\u8c03\u63a7\u6765\u8bbe\u8ba1\u7528\u4f5c\u8f7d\u4f53\u7684\u65b0\u578b\u7eb3\u7c73\u7ed3\u6784\u3002\u4f5c\u8005\u8be6\u7ec6\u8ba8\u8bba\u4e86\u7eb3\u7c73\u7c92\u5b50\u3001\u836f\u7269\u5206\u5b50\u53ca\u751f\u7269\u7cfb\u7edf\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u53ca\u7ed3\u6784-\u6027\u8d28\u5173\u7cfb\u3002\u968f\u540e\uff0c\u4f5c\u8005\u91cd\u70b9\u8ba8\u8bba\u4e86SNP\u4ece\u7eb3\u7c73\u836f\u7269\u8f7d\u4f53\u5230\u751f\u7269\u529f\u80fd\u8c03\u8282\u5242\u7684\u6982\u5ff5\u8f6c\u53d8\u3002\u901a\u8fc7\u5c06\u751f\u7269\u6d3b\u6027\u57fa\u56e2\u6574\u5408\u5230SNP\u4e2d\u4ee5\u8c03\u8282\u751f\u7269\u4fe1\u53f7\u4f20\u5bfc\uff0c\u8fd9\u7c7b\u65b0\u578b\u751f\u7269\u529f\u80fd\u8c03\u8282\u5242\u5728\u63a7\u5236\u764c\u7ec6\u80de\u7684\u6b7b\u4ea1\u6a21\u5f0f\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\u719f\u5316\uff0c\u5de8\u566c\u7ec6\u80de\u8868\u578b\u8c03\u63a7\u548c\u80bf\u7624\u5fae\u73af\u5883\u8c03\u8282\u7b49\u5e94\u7528\u4e2d\u5177\u6709\u4f18\u8d8a\u6027\u80fd\u3002\u8be5\u6210\u679c\u4ee5 \u201cSilica-Based Nanoparticles for Biomedical Applications: From Nanocarriers to Biomodulators\u201d<\/strong> \u4e3a\u9898\u53d1\u8868\u5728Acc. Chem. Res.<\/strong>\u4e0a<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1.<\/strong>\u7ec4\u6210\u548c\u7ed3\u6784\u53ef\u63a7\u7684\u4e8c\u6c27\u5316\u7845\u57fa\u7eb3\u7c73\u9897\u7c92\u7528\u4f5c\u7eb3\u7c73\u836f\u7269\u8f7d\u4f53\u548c\u751f\u7269\u529f\u80fd\u8c03\u8282\u5242<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>2.<\/strong>\u6a21\u62df\u75c5\u6bd2\u5f62\u8c8c\u7684SNP<\/p>\n

\"\"<\/p>\n

\uff08A\uff0cB\uff09\u8868\u9762\u5149\u6ed1SNP\u548c\u6a21\u62df\u75c5\u6bd2SNP\u7684\u5408\u6210\u4ee5\u53ca\u7ec6\u80de\u9012\u9001\u6027\u80fd\u7684\u6bd4\u8f83<\/p>\n

\uff08C\uff0cD\uff09\u626b\u63cf\u7535\u5b50\u663e\u5fae\u955c\uff08SEM\uff09\u56fe\u50cf\u663e\u793a\u75c5\u6bd2\u6a21\u4eff\u7c97\u7cd9\u8868\u9762<\/p>\n

\uff08E\uff09\u503e\u659c\u7cfb\u5217\u7684\u96f6\u503e\u659c\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\uff08TEM\uff09\u6295\u5f71<\/p>\n

\uff08F\uff09\u91cd\u5efa\u5355\u4e2a\u7c92\u5b50\u7684\u8868\u9762\u6e32\u67d3<\/p>\n

\uff08G\uff0cH\uff09\uff08\u5de6\uff091-NH2\uff08\u5149\u6ed1\u7684SNP\uff09\u548c\uff08\u53f3\uff093-NH2\uff08\u6a21\u4eff\u75c5\u6bd2\u7684SNP\uff09\u9012\u9001\u7684Cy3-oligoDNA\uff08\u7ea2\u8272\uff09\u7684\u5171\u805a\u7126\u663e\u5fae\u955c\u56fe\u50cf<\/p>\n

\uff08I\uff09\u901a\u8fc7\u51dd\u80f6\u963b\u6ede\u5206\u6790\u8ba1\u7b97\u7684\u751f\u7269\u5206\u5b50\u4fdd\u6301\u80fd\u529b\u7684\u7814\u7a76<\/p>\n

\uff08J\uff09Cy3-oligoDNA \/\u7eb3\u7c73\u9897\u7c92\u590d\u5408\u7269\u7684\u7ec6\u80de\u5438\u6536\u6548\u7387\u6bd4\u8f83<\/p>\n

\uff08K\uff09\u901a\u8fc7\u57fa\u4e8e\u5e73\u6ed1SNP\u6216\u6a21\u4eff\u75c5\u6bd2SNP\u7684siRNA\u5236\u5242\u5904\u7406\u7684\u764c\u7ec6\u80de\u7684\u7ec6\u80de\u751f\u5b58\u529b<\/p>\n

\u56fe<\/strong>3.<\/strong>\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u82b1\u7c89\u5bf9\u7ec6\u83cc\u8868\u73b0\u51fa\u589e\u5f3a\u7684\u7c98\u9644\u529b\u548c\u6eb6\u83cc\u9176\u9012\u9001\u7279\u6027<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u901a\u8fc7\u7c98\u6027\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u82b1\u7c89\u6709\u6548\u6eb6\u83cc\u9176\u7684\u793a\u610f\u56fe<\/p>\n

\uff08B\uff09\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u82b1\u7c89\u7684TEM\u56fe\u50cf<\/p>\n

\uff08C\uff09\u7c98\u9644\u5728\u5927\u80a0\u6746\u83cc\u8868\u9762\u7684\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u82b1\u7c89\u7684SEM\u56fe\u50cf<\/p>\n

\uff08D\uff09\u6e38\u79bb\u6eb6\u83cc\u9176\u548c\u8f7d\u6709\u6eb6\u83cc\u9176\u7684\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u82b1\u7c89\uff08R-MSHSs\uff09\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u6297\u83cc\u6d3b\u6027<\/p>\n

\uff08E\uff09\u8f7d\u6709\u6eb6\u83cc\u9176\u7684\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u82b1\u7c89\u5904\u740624\u5c0f\u65f6\u7684\u5927\u80a0\u6746\u83cc\u7684SEM\u56fe\u50cf<\/p>\n

\uff08F\uff09\u743c\u8102\u5e73\u677f\u5728\u4e0d\u540c\u5904\u7406\u540e\u663e\u793a\u5c0f\u80a0\u7ec6\u83cc\u83cc\u843d<\/p>\n

\u56fe<\/strong>4.<\/strong>\u4e0d\u5bf9\u79f0\u5934\u5c3e<\/strong>SNP<\/strong>\u663e\u793a\u589e\u5f3a\u7684\u514d\u75ab\u523a\u6fc0\u6d3b\u6027\u548c\u8840\u6db2\u76f8\u5bb9\u6027<\/strong><\/p>\n

\"\"<\/p>\n

(A,C)\u5728\u4e0d\u540cTEOS\u4f53\u79ef\u4e0b\u5236\u5907\u7684HTMSN\u7684TEM\u548cSEM\u56fe\u50cf<\/p>\n

(D)\u4e0e\u4e0d\u540c\u7684\u7eb3\u7c73\u9897\u7c92\u4ee5240\u03bcg\/ mL\u5b75\u80b2\u540e\u7684\u5c0f\u9f20RBC\u7684\u6eb6\u8840\u767e\u5206\u6bd4<\/p>\n

(E)\u5728\u5ba4\u6e29\u4e0b\u5b75\u80b22\u5c0f\u65f6\u7684RBC\u7684SEM\u56fe\u50cf<\/p>\n

(F,G)\u5de8\u566c\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u4e0aCD 86\u7684\u8868\u8fbe\u6c34\u5e73<\/p>\n

\u56fe<\/strong>5.<\/strong>\u5177\u6709\u9525\u72b6\u5b54\u7ed3\u6784\u7684<\/strong>SNP<\/strong>\u7684\u8868\u5f81\uff0c\u5f62\u6210\u673a\u7406\u548c\u86cb\u767d\u4f20\u9012<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09C. Xu\u5728\u5854\u65af\u9a6c\u5c3c\u4e9a\u5dde\u62cd\u6444\u7684\u5927\u4e3d\u82b1\u7167\u7247<\/p>\n

\uff08B-D\uff09\u4f4e\u500d\uff0c\u9ad8\u500d\u548cMSNs-CC\u7684ET\u5207\u7247\u7684TEM\u56fe\u50cf<\/p>\n

\uff08E\uff09\u5efa\u8bae\u7684MSNs-CC\u5f62\u6210\u673a\u5236<\/p>\n

\uff08F\uff09\u7528MSNs-CC-RITC\u5904\u7406\u7684N2a\u7ec6\u80de\u7684\u5171\u805a\u7126\u663e\u5fae\u955c\u56fe\u50cf<\/p>\n

\uff08G-H\uff09\u8f7d\u6709\u03b2-Gal\u7684MSNs-CC\u548c\u6e38\u79bb\u03b2-Gal\u5904\u7406\u540e\u7684N2a\u7ec6\u80de\u7684\u663e\u5fae\u56fe\u50cf<\/p>\n

\u56fe<\/strong>6.<\/strong>\u63ba\u5165\u4e8c\u786b\u952e\u7684<\/strong>DMONs-PEI<\/strong>\u5728\u4f53\u5185\u548c\u4f53\u5916\u4e0a\u8c03\u96be\u4ee5\u8f6c\u67d3\u7ec6\u80de\u4e2d\u7684<\/strong>mRNA<\/strong>\u8f6c\u67d3<\/strong><\/p>\n

\"\"<\/p>\n

A\uff09\u7eb3\u7c73\u5316\u5b66\u4e0a\u8c03mRNA\u7ffb\u8bd1\u7684\u793a\u610f\u56fe<\/p>\n

B\uff09\u4e0eDMONs-PEI\/mRNA\u590d\u5408\u7269\u5b75\u80b248\u5c0f\u65f6\u7684RAW264.7\u7ec6\u80de\u7684\u5171\u805a\u7126\u56fe\u50cf<\/p>\n

C\uff09\u4e0eNPs-PEI-mRNA\u590d\u5408\u7269\u5b75\u80b248\u5c0f\u65f6\u7684RAW 264.7\u7ec6\u80de\u7684EGFP\u9633\u6027\u7ec6\u80de\u767e\u5206\u6bd4\u7684\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790<\/p>\n

D-E\uff09\u5728BALB\/c\u5c0f\u9f20\u4e2dmCherry mRNA\u4f20\u9012\u7684\u4f53\u5185\u8367\u5149\u56fe\u50cf\uff0c\u8367\u5149\u7684\u5b9a\u91cf\u7ed3\u679c<\/p>\n

\u56fe<\/strong>7.<\/strong>\u57fa\u4e8e\u6742\u5316\u6709\u673a\u7845\u7684\u7eb3\u7c73\u53cd\u5e94\u5668\u540c\u65f6\u8c03\u8282\u764c\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de\u529f\u80fd<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u7eb3\u7c73\u53cd\u5e94\u5668\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u534f\u540c\u6539\u5584\u764c\u75c7\u5316\u5b66\u514d\u75ab\u7597\u6cd5\u7684\u793a\u610f\u56fe<\/p>\n

\uff08B-E\uff09\u7eb3\u7c73\u53cd\u5e94\u5668\u7684SEM\uff0cTEM\uff0c\u6697\u573a\u626b\u63cfTEM\u548c\u80fd\u91cf\u8272\u6563X\u5c04\u7ebf\u5149\u8c31\u5143\u7d20\u6620\u5c04\u56fe<\/p>\n

\uff08F\uff09\u7eb3\u7c73\u53cd\u5e94\u5668\u8bf1\u5bfc\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u6210\u719f<\/p>\n

\uff08G\uff0cH\uff09\u7eb3\u7c73\u53cd\u5e94\u5668\u5bf9ICD\u7684\u8c03\u8282\uff0c\u5176\u7279\u5f81\u4e3a\u9499\u7f51\u86cb\u767d\u7684\u8868\u9762\u66b4\u9732<\/p>\n

\uff08I\uff0cJ\uff09\u7eb3\u7c73\u53cd\u5e94\u5668\u4e0e\u963f\u9709\u7d20\u548cPD-L1\u6297\u4f53\u8054\u5408\u5f15\u8d77\u7684\u5168\u8eab\u6297\u80bf\u7624\u514d\u75ab<\/p>\n

\u56fe<\/strong>8.<\/strong>\u7eb3\u7c73\u87af\u5408\u5242\u540c\u65f6\u8bf1\u5bfc\u6297\u8840\u7ba1\u751f\u6210\u548c\u80bf\u7624\u8840\u7ba1\u963b\u585e\u4ee5\u6291\u5236\u80bf\u7624<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u7eb3\u7c73\u87af\u5408\u5242\u8bf1\u5bfc\u540c\u65f6\u6297\u8840\u7ba1\u751f\u6210\u548c\u80bf\u7624\u8840\u7ba1\u963b\u585e\u7684\u793a\u610f\u56fe<\/p>\n

\uff08B\uff09\u7eb3\u7c73\u87af\u5408\u5242\u7684TEM\u56fe\u50cf<\/p>\n

\uff08C\uff09\u7eb3\u7c73\u87af\u5408\u5242\u5bf9\u94dc\u548c\u78f7\u9178\u76d0\u79bb\u5b50\u7684\u805a\u96c6<\/p>\n

\uff08D\uff09\u80bf\u7624\u8840\u7ba1\u963b\u585e\u7684\u5b9e\u65f6\u6210\u50cf<\/p>\n

\uff08E\uff09\u901a\u8fc7CD31\u6297\u4f53\u67d3\u8272\u663e\u793a\u7684\u7eb3\u7c73\u87af\u5408\u5242\u7684\u6297\u8840\u7ba1\u751f\u6210\u6d3b\u6027<\/p>\n

\uff08F-G\uff09\u7eb3\u7c73\u87af\u5408\u5242\u57284T1\u548cCT26\u5f02\u79cd\u79fb\u690d\u80bf\u7624\u6a21\u578b\u4e2d\u7684\u6297\u80bf\u7624\u6d3b\u6027<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5<\/strong>\uff1aSilica-Based Nanoparticles for Biomedical Applications: From Nanocarriers to Biomodulators. Acc. Chem. Res., <\/em>2020<\/strong>, DOI: 10.1021\/acs.accounts.0c00280<\/p>\n

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