{"id":206602,"date":"2020-08-07T06:27:48","date_gmt":"2020-08-06T22:27:48","guid":{"rendered":"\/\/m.iemloyee.com\/?p=206602"},"modified":"2020-08-06T21:28:00","modified_gmt":"2020-08-06T13:28:00","slug":"%e6%b5%99%e5%a4%a7%e9%bb%84%e9%a3%9e%e9%b9%a4%e7%ad%89%e4%ba%ba-angew-%ef%bc%9a%e6%b0%a7%e6%b0%94%e5%93%8d%e5%ba%94%e7%9a%84%e5%8f%8c%e5%8a%9f%e8%83%bdptii%e9%87%91%e5%b1%9e%e7%ac%bc%e7%94%a8","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=206602","title":{"rendered":"\u6d59\u5927\u9ec4\u98de\u9e64\u7b49\u4eba Angew.\uff1a\u6c27\u6c14\u54cd\u5e94\u7684\u53cc\u529f\u80fdPt(II)\u91d1\u5c5e\u7b3c\u7528\u4e8e\u4e4f\u6c27\u6210\u50cf\u548c\u56fe\u50cf\u5f15\u5bfc\u5316\u5b66\u6cbb\u7597"},"content":{"rendered":"<p><strong>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n<p>\u4f17\u6240\u5468\u77e5\uff0c\u7ec6\u80de\u5185\u6c27\u6c14\uff08O<sub>2<\/sub>\uff09\u662f\u6709\u6c27\u547c\u5438\u6240\u5fc5\u9700\u7684\uff0c\u4e3a\u751f\u547d\u7cfb\u7edf\u63d0\u4f9b\u4ee3\u8c22\u80fd\u91cf\u3002\u901a\u5e38\uff0c\u5177\u6709\u5feb\u901f\u589e\u6b96\u548c\u65b0\u9648\u4ee3\u8c22\u7684\u7ec4\u7ec7\uff08\u5b9e\u4f53\u7624\u7b49\uff09\u53ef\u4ee5\u6444\u5165\u66f4\u591a\u7684O<sub>2<\/sub>\uff0c\u4ece\u800c\u5bfc\u81f4\u7f3a\u6c27\u3002\u56e0\u6b64\uff0c\u68c0\u6d4b\u548c\u6210\u50cf\u6d3b\u7ec6\u80de\u4e2d\u7684\u4e4f\u6c27\u4e0d\u4ec5\u5bf9\u4e8e\u51c6\u786e\u7684\u764c\u75c7\u8bca\u65ad\u5f88\u91cd\u8981\uff0c\u800c\u4e14\u5bf9\u8bc4\u4f30\u6cbb\u7597\u6548\u679c\u4e5f\u975e\u5e38\u6709\u7528\u3002\u7136\u800c\uff0c\u7531\u4e8e\u751f\u7269\u8fd8\u539f\uff0c\u68c0\u6d4b\u8fd8\u539f\u9176\u63a2\u9488\u7684\u53d1\u5c04\u662f\u4e0d\u53ef\u9006\u7684\uff0c\u9650\u5236\u4e86\u5176\u5728\u53ef\u9006\u76d1\u6d4b\u7ec6\u80de\u5185O<sub>2<\/sub>\u6c34\u5e73\u4e2d\u7684\u8fdb\u4e00\u6b65\u5e94\u7528\u3002\u540c\u65f6\uff0c\u5927\u591a\u6570\u78f7\u5149\u63a2\u9488\u57fa\u4e8e\u5355\u78f7\u5149\u67d3\u6599\uff0c\u5355\u53d1\u5c04\u5f3a\u5ea6\u6613\u88ab\u63a2\u9488\u7684\u6d53\u5ea6\u548c\u5176\u5b83\u751f\u7269\u6761\u4ef6\u6539\u53d8\uff0c\u800c\u76f8\u5bf9\u7f3a\u4e4f\u51c6\u786e\u6027\u548c\u53ef\u9760\u6027\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u5177\u6709\u591a\u91cd\u53d1\u5c04\u548c\u78f7\u5149\u7279\u6027\u7684\u65b0\u578b\u4f4e\u6c27\u63a2\u9488\u975e\u5e38\u91cd\u8981\u3002\u8d85\u5206\u5b50\u914d\u4f4d\u5316\u5408\u7269\uff08SCCs\uff09\u662f\u4e00\u79cd\u4f9d\u8d56\u4e8e\u91d1\u5c5e\u53d7\u4f53\u548c\u8def\u6613\u65af\u78b1\u6027\u6709\u673a\u914d\u4f53\u7684\u81ea\u53d1\u81ea\u7ec4\u88c5\u7684\u5316\u5408\u7269\uff0c\u5728\u6a21\u62df\u548c\u7814\u7a76\u5929\u7136\u8d85\u5206\u5b50\u7ec4\u88c5\u65b9\u9762\u88ab\u5e7f\u6cdb\u5173\u6ce8\u3002\u76ee\u524d\uff0c\u7cbe\u786e\u7ec4\u88c5\u7684\u5404\u79cdPt(II)\u91d1\u5c5e\u6742\u73af\u548c\u91d1\u5c5e\u8f7d\u7269\uff0c\u88ab\u5e7f\u6cdb\u7528\u4e8e\u7ec6\u80de\u6210\u50cf\u7b49\u9886\u57df\u3002\u56e0\u6b64\uff0c\u5728\u4f4e\u6c27\u6210\u50cf\u4e2d\u5e94\u7528Pt(II) SCCs\u662f\u6709\u5e0c\u671b\u7684\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u7f8e\u56fd\u72b9\u4ed6\u5927\u5b66\u7684Peter J. Stang\u6559\u6388\u3001\u6d59\u6c5f\u5927\u5b66\u7684\u9ec4\u98de\u9e64\u6559\u6388\u548c\u55bb\u56fd\u707f\u3001\u5929\u6d25\u5927\u5b66\u7684\u738b\u751f\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba<\/strong>\u62a5\u9053\u4e86\u4e00\u79cd\u5177\u6709\u53cc\u91cd\u53d1\u5c04\u548c\u78f7\u5149\u6027\u8d28\u7684Pt(II)-\u91d1\u5c5e\u7b3c\uff08<strong>1<\/strong>\uff09\uff0c\u53ca\u5176\u5728\u4e4f\u6c27\u73af\u5883\u4e0b\u7684\u6210\u50cf\u5e94\u7528\u3002\u4f5c\u8005\u9009\u62e9Pt(II)-\u5bf9-\u56db\uff084-\u7fa7\u57fa\u82ef\u57fa\uff09\u535f\u5549\u94a0\u76d0\uff08<strong>2<\/strong>\uff09\u4f5c\u4e3a\u78f7\u5149\u914d\u4f53\uff0c\u56e0\u4e3a\u5176\u5728\u771f\u7a7a\u6c14\u6c1b\u4e2d\u5177\u6709\u957f\u5bff\u547d\u4e09\u91cd\u6001\u7684\u5f3a\u7ea2\u8272\u78f7\u5149\uff0c\u5176\u5f3a\u5ea6\u9ad8\u5ea6\u4f9d\u8d56\u4e8eO<sub>2<\/sub>\u6d53\u5ea6\uff0c\u662f\u4e00\u79cd\u654f\u611f\u7684O<sub>2<\/sub>\u63a2\u9488\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u5229\u7528\u84bd\uff08<strong>3<\/strong>\uff09\u4f5c\u4e3a\u84dd\u8272\u8367\u5149\u56e2\u3002\u4e24\u4e2a\u914d\u4f53\u7684\u7ec4\u5408\u8d4b\u4e88<strong>1<\/strong>\u654f\u611f\u7684O<sub>2<\/sub>\u54cd\u5e94\u7ea2\u8272\u78f7\u5149\u548c\u7a33\u5b9a\u7684\u84dd\u8272\u8367\u5149\u3002\u8be5\u91d1\u5c5e\u7b3c\u8fd8\u7528\u4e8e\u4f53\u5916\u548c\u4f53\u5185\u7684\u4f4e\u6c27\u6210\u50cf\u3002\u5bf9\u6bd4\u4f20\u7edf\u7684\u5355\u53d1\u5c04\u5f0f\u4e4f\u6c27\u63a2\u9488\uff0c\u8be5\u91d1\u5c5e\u7b3c\u4e0d\u4ec5\u663e\u793a\u51fa\u53ef\u9006\u548c\u654f\u611f\u7684O<sub>2<\/sub>\u54cd\u5e94\u78f7\u5149\uff0c\u800c\u4e14\u8fd8\u901a\u8fc7\u8ba1\u7b97\u7ea2\u8272\u548c\u84dd\u8272\u53d1\u5c04\u4e4b\u95f4\u7684\u6bd4\u7387\u4e3a\u4e4f\u6c27\u6210\u50cf\u548c\u68c0\u6d4b\u63d0\u4f9b\u4e86\u66f4\u53ef\u9760\u7684\u6807\u51c6\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u5229\u7528\u4e24\u4eb2\u6027\u4e8c\u5d4c\u6bb5\u5171\u805a\u7269\u5305\u5c01\u8be5\u91d1\u5c5e\u7b3c\uff0c\u4ee5\u5236\u5907\u51fa\u7a33\u5b9a\u7684\u7eb3\u7c73\u9897\u7c92\u5236\u5242\u3002\u8be5\u7eb3\u7c73\u5236\u5242\u7684\u5faa\u73af\u65f6\u95f4\u548c\u80bf\u7624\u79ef\u7d2f\u5f97\u5230\u663e\u7740\u6539\u5584\uff0c\u6709\u5229\u4e8e\u6210\u50cf\u548c\u6cbb\u7597\u3002\u4f53\u5185\u5b9e\u9a8c\u8868\u660e\uff0c\u8be5\u6750\u6599\u53ef\u4f5c\u4e3a\u4f18\u5f02\u7684\u80bf\u7624\u6cbb\u7597\u5242\uff0c\u7528\u4e8e\u80bf\u7624\u4f4e\u6c27\u6210\u50cf\u548c\u5316\u7597\uff0c\u53ef\u6709\u6548\u7684\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u800c\u526f\u4f5c\u7528\u53ef\u5ffd\u7565\u4e0d\u8ba1\u3002\u603b\u4e4b\uff0c\u672c\u6587\u4e2d\u7684\u6cbb\u7597\u6027\u91d1\u5c5e\u7597\u6cd5\u53ef\u4ee5\u4e3a\u589e\u5f3a\u5206\u5b50\u8bca\u65ad\u548c\u56fe\u50cf\u6307\u5bfc\u7684\u6cbb\u7597\u5e94\u7528\u63d0\u4f9b\u524d\u666f\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201cDual-Emissive Pt(II) Metallacage with Sensitive Oxygen Response for Imaging of Hypoxia and Imaging-Guided Chemotherapy\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<strong>Angew. Chem. Int. Ed.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u89e3\u6790\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u91d1\u5c5e\u7b3c\u548c\u7eb3\u7c73\u5236\u5242\u7684\u5236\u5907\u793a\u610f\u56fe<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-206603\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/1-18.png\" alt=\"\" width=\"600\" height=\"277\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/1-18.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/1-18-300x139.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202009442\" target=\"_blank\" rel=\"noopener\">Dual-Emissive Pt(II) Metallacage with Sensitive Oxygen Response for Imaging of Hypoxia and Imaging-Guided Chemotherapy<\/a><\/strong>\uff08<em>Angew. Chem. Int. Ed.<\/em>, <strong>2020<\/strong>, DOI: 10.1002\/anie.202009442\uff09<\/p>\n<p>\n \u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u4f17\u6240\u5468\u77e5\uff0c\u7ec6\u80de\u5185\u6c27\u6c14\uff08O2\uff09\u662f\u6709\u6c27\u547c\u5438\u6240\u5fc5\u9700\u7684\uff0c\u4e3a\u751f\u547d\u7cfb\u7edf\u63d0\u4f9b\u4ee3\u8c22\u80fd\u91cf\u3002\u901a\u5e38\uff0c\u5177\u6709\u5feb\u901f\u589e\u6b96\u548c\u65b0\u9648\u4ee3\u8c22\u7684\u7ec4\u7ec7\uff08\u5b9e\u4f53\u7624\u7b49\uff09\u53ef\u4ee5\u6444\u5165\u66f4\u591a\u7684O2\uff0c\u4ece\u800c\u5bfc\u81f4&#8230;<\/p>\n","protected":false},"author":7770,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[4433],"class_list":["post-206602","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-mnps"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/206602"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7770"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=206602"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/206602\/revisions"}],"predecessor-version":[{"id":206936,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/206602\/revisions\/206936"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=206602"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=206602"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=206602"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}