{"id":206580,"date":"2020-08-06T06:25:04","date_gmt":"2020-08-05T22:25:04","guid":{"rendered":"\/\/m.iemloyee.com\/?p=206580"},"modified":"2020-08-05T20:25:19","modified_gmt":"2020-08-05T12:25:19","slug":"%e9%99%88%e5%ad%a6%e6%80%9d%e8%82%96%e6%98%a5%e7%94%9fam%ef%bc%9a%e4%bb%bf%e5%ae%bf%e4%b8%bb%e9%98%b2%e5%be%a1%e8%82%bd%e7%bb%93%e6%9e%84%e7%9a%84%e5%90%88%e6%88%90%e8%81%9a%e5%a4%9a%e8%82%bd","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=206580","title":{"rendered":"\u9648\u5b66\u601d&\u8096\u6625\u751fAM\uff1a\u4eff\u5bbf\u4e3b\u9632\u5fa1\u80bd\u7ed3\u6784\u7684\u5408\u6210\u805a\u591a\u80bd\u5b9e\u73b0\u65e0\u836f\u7269\u6297\u764c\u7b56\u7565"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

\u5316\u7597\u662f\u6cbb\u7597\u6076\u6027\u80bf\u7624\u6700\u91cd\u8981\u548c\u4e0d\u53ef\u7f3a\u5c11\u7684\u65b9\u6cd5\u4e4b\u4e00\u3002\u7136\u800c\u76ee\u524d\u4f7f\u7528\u7684\u6297\u80bf\u7624\u836f\u7269\u5927\u591a\u5b58\u5728\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u548c\u6613\u4ea7\u751f\u8010\u836f\u6027\u7b49\u7f3a\u70b9\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u5c40\u9650\u6027\uff0c\u63d0\u9ad8\u6297\u80bf\u7624\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\uff0c\u57fa\u4e8e\u805a\u5408\u7269\u7684\u6297\u80bf\u7624\u6cbb\u7597\u7b56\u7565\u88ab\u5e7f\u6cdb\u5f00\u53d1\uff0c\u5982\u8bbe\u8ba1\u805a\u5408\u7269-\u836f\u7269\u5076\u8054\u7269\u548c\u836f\u7269\u8d1f\u8f7d\u7684\u805a\u5408\u7269\u836f\u7269\u9012\u9001\u7cfb\u7edf\u7b49\u3002\u5728\u8fd9\u4e9b\u5e94\u7528\u4e2d\uff0c\u4e00\u822c\u8981\u6c42\u805a\u5408\u7269\u5177\u6709\u201c\u751f\u7269\u60f0\u6027\u201d\uff0c\u5373\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u751f\u7269\u53ef\u964d\u89e3\u6027\u80fd\u3002\u6709\u522b\u4e8e\u8fd9\u4e9b\u201c\u751f\u7269\u60f0\u6027\u201d\u6750\u6599\uff0c\u6784\u5efa\u5177\u6709\u672c\u5f81\u5e7f\u8c31\u6297\u80bf\u7624\u6d3b\u6027\u7684\u805a\u5408\u7269\u7684\u901a\u7528\u7b56\u7565\u8fd8\u5c1a\u672a\u62a5\u9053\u3002\u5bbf\u4e3b\u9632\u5fa1\u80bd\uff08HDPs\uff09\u5e7f\u6cdb\u5b58\u5728\u4e8e\u6240\u6709\u591a\u7ec6\u80de\u751f\u7269\u4e2d\uff0c\u5728\u975e\u7279\u5f02\u6027\u9632\u5fa1\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u867d\u7136\u65e9\u671f\u7684\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728HDPs\u7684\u6297\u83cc\/\u771f\u83cc\u6d3b\u6027\u4e0a\uff0c\u4f46\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u4e5f\u63ed\u793a\u4e86HDPs\u6f5c\u5728\u7684\u6297\u764c\u6d3b\u6027\u3002\u8fd9\u662f\u7531\u4e8e\u764c\u7ec6\u80de\u5177\u6709\u72ec\u7279\u7684\u819c\u7ed3\u6784\u7279\u6027\uff0c\u4f7f\u5f97\u9633\u79bb\u5b50HDPs\u6709\u671b\u901a\u8fc7\u201c\u819c\u6eb6\u89e3\u201d\u673a\u5236\u9009\u62e9\u6027\u5730\u7ed3\u5408\u5e76\u88c2\u89e3\u80bf\u7624\u7ec6\u80de\u3002\u8fd1\u51e0\u5341\u5e74\u6765\uff0c\u4eba\u4eec\u4e00\u76f4\u81f4\u529b\u4e8e\u5f00\u53d1\u7528\u4e8e\u6297\u83cc\u9886\u57df\u7684\u4effHDPs\u7ed3\u6784\u7684\u805a\u5408\u7269\uff0c\u800c\u7528\u4e8e\u6297\u80bf\u7624\u7684\u4effHDPs\u7ed3\u6784\u7684\u805a\u5408\u7269\u5f00\u53d1\u5374\u76f8\u5bf9\u6ede\u540e\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u957f\u6625\u5e94\u5316\u6240\u9648\u5b66\u601d\u9662\u58eb\u548c\u8096\u6625\u751f\u526f\u7814\u7a76\u5458\u56e2\u961f<\/strong>\u62a5\u9053\u4e00\u79cd\u7531\u4effHDPs\u7ed3\u6784\u7684\u5408\u6210\u805a\u591a\u80bd\u5b9e\u73b0\u7684\u65e0\u836f\u7269\u6297\u764c\u7b56\u7565\u3002\u8fd9\u79cd\u805a\u591a\u80bd\u572812\u79cd\u80bf\u7624\u7ec6\u80de\u7cfb\u4e2d\u8868\u73b0\u51fa\u5e7f\u8c31\u7684\u6297\u764c\u6d3b\u6027\uff0c\u5176\u4e2d\u5305\u62ec\u8010\u836f\u548c\u9ad8\u8f6c\u79fb\u6027\u80bf\u7624\u7ec6\u80de\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u79cd\u9633\u79bb\u5b50\u6297\u764c\u591a\u80bd\uff08ACPP\uff09\u53ef\u4ee5\u901a\u8fc7\u819c\u6eb6\u89e3\u673a\u5236\u5728\u51e0\u5206\u949f\u5185\u76f4\u63a5\u8bf1\u5bfc\u764c\u7ec6\u80de\u5feb\u901f\u574f\u6b7b\u3002\u6b64\u5916\uff0c\u4e3a\u4e86\u5b9e\u73b0ACPP\u7684\u4f53\u5185\u5e94\u7528\uff0c\u8fd8\u5236\u5907\u4e86\u4e00\u79cdpH\u654f\u611f\u7684\u4e24\u6027\u79bb\u5b50ACPP\u884d\u751f\u7269\uff08DA-ACPP\uff09\u3002DA-ACPP\u5728\u4e2d\u6027\u751f\u7406\u6761\u4ef6\u4e0b\u8868\u73b0\u51fa\u53ef\u5ffd\u7565\u7684\u6eb6\u8840\u4f5c\u7528\uff0c\u5728\u5f31\u9178\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u53ef\u54cd\u5e94\u6027\u8131\u53bb\u9634\u79bb\u5b50\u4fee\u9970\u57fa\u56e2\u8fd8\u539f\u6210\u9633\u79bb\u5b50ACPP\uff0c\u4ece\u800c\u9009\u62e9\u6027\u6740\u4f24\u764c\u7ec6\u80de\u3002\u6700\u7ec8\uff0cDA-ACPP\u57284T1\u539f\u4f4d\u4e73\u817a\u80bf\u7624\u6a21\u578b\u548cB16-F10\u9ed1\u8272\u7d20\u7624\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2d\u5747\u663e\u793a\u51fa\u6709\u6548\u7684\u80bf\u7624\u751f\u957f\u6291\u5236\u4f5c\u7528\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cAntineoplastic Drug-Free Anticancer Strategy Enabled by Host Defense Peptides- Mimicking Synthetic Polypeptides<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aAdv. Mater.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u6d41\u7a0b\u56fe\u3001<\/strong>ACPP<\/strong>\u8bf1\u5bfc\u764c\u7ec6\u80de\u574f\u6b7b\u7684\u201c\u56db\u6b65\u6cd5\u201d\u819c\u6eb6\u89e3\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe\u4e00\u3001<\/strong>DA-ACPPs<\/strong>\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5728PBS7.4\u6761\u4ef6\u4e0b\uff0cACPP\u548cDA-ACPP\u5728\u4e0d\u540c\u6d53\u5ea6\u4e0b\u7684\u6eb6\u8840\u6027\u3002<\/p>\n

\uff08b\uff09\u5728\u9178\u6027\u80bf\u7624\u73af\u5883\u4e2d\uff0c\u901a\u8fc7\u9178\u8bf1\u5bfc2,3-\u4e8c\u7532\u57fa\u9a6c\u6765\u9170\u80fa\uff08MAA\uff09\u952e\u65ad\u88c2\uff0cDA-ACPP\u5411ACPP\u8f6c\u5316\u7684\u53cd\u5e94\u8fc7\u7a0b\u793a\u610f\u56fe\u3002<\/p>\n

\uff08c\uff09pH 6.8\u6216pH 7.4\u65f6DA-ACPP\uff080.1 mg mL-1<\/sup>\uff09\u7684Zeta\u7535\u4f4d\u53d8\u5316\u3002<\/p>\n

\uff08d-e\uff094T1\u7ec6\u80de\u548cB16-F10\u7ec6\u80de\u5728pH 6.8\u6216pH 7.4\u4e2d\u4e0e\u4e0d\u540c\u6d53\u5ea6DA-ACPP\u57f9\u517b24\u5c0f\u65f6\u540e\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n

\uff08f\uff09\u572837\u00b0C\u4e0b\uff0c\u7528250\u00b5g mL\u22121<\/sup> DA-ACPP\u5904\u740612\u5c0f\u65f6\u621624\u5c0f\u65f6\u540e\uff0c\u5728pH 6.8\u6216pH 7.4\u4e0b\u5904\u7406B16-F10\u7ec6\u80de\u7684\u626b\u63cf\u7535\u5b50\u663e\u5fae\u955c\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e8c\u3001\u539f\u4f4d\u7624\u6a21\u578b\u4e2d\u8bc4\u4f30<\/strong>DA-ACPPs<\/strong>\u7684\u4f53\u5185\u6297\u80bf\u7624\u6d3b\u6027<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u57280\u30012\u30014\u30018\u548c12\u5929\u5206\u522b\u7624\u5185\u6ce8\u5c04PBS\u3001SA-ACPP\uff0830 mg kg-1<\/sup>\uff09\u548cDA-ACPP\uff085\u300115\u621630 mg kg-1<\/sup>\uff09\u540e4T1\u8377\u7624BALB\/c\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

\uff08b\uff09\u8ddd\u7b2c\u4e00\u6b21\u6cbb\u7597\u7b2c17\u5929\u540e\u8bb0\u5f55\u80bf\u7624\u56fe\u50cf\u3002<\/p>\n

\uff08c\uff0917\u5929\u540e\u5404\u6cbb\u7597\u7ec4\u5e73\u5747\u80bf\u7624\u8d28\u91cf\u3002<\/p>\n

\uff08d\uff09BALB\/c\u5c0f\u9f20\u6cbb\u7597\u671f\u95f4\u4f53\u91cd\u7684\u53d8\u5316\u3002<\/p>\n

\uff08e\uff09\u5404\u7ec4\u5c0f\u9f20\u80bf\u7624\u5207\u7247\u5207\u9664\u540eH&E\u67d3\u8272\u3002<\/p>\n

\u56fe\u4e09\u3001\u9ed1\u8272\u7d20\u7624\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2d\u8bc4\u4f30<\/strong>DA-ACPPs<\/strong>\u7684\u4f53\u5185\u6297\u80bf\u7624\u6d3b\u6027<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5b9e\u9a8c\u8fc7\u7a0b\u793a\u610f\u56fe\u3002<\/p>\n

\uff08b\uff09\u6cbb\u7597\u7ed3\u675f\u65f6\u80ba\u90e8\u56fe\u50cf\u3002<\/p>\n

\uff08c\uff09\u6cbb\u7597\u7ed3\u675f\u65f6\u5404\u7ec4\u80ba\u7684\u8d28\u91cf\u3002<\/p>\n

\uff08d\uff09\u5728\u4f4e\uff08200\u00d7\uff0c\u6bd4\u4f8b\u5c3a\uff1a100\u00b5m\uff09\u548c\u9ad8\uff08400\u00d7\uff0c\u6bd4\u4f8b\u5c3a\uff1a50\u00b5m\uff09\u653e\u5927\u500d\u6570\u4e0b\u89c2\u5bdf\u4e0d\u540c\u5b9e\u9a8c\u7ec4\u5c0f\u9f20\u80ba\u7ec4\u7ec7\u7684H&E\u53ca\u589e\u6b96\u7ec6\u80de\u6838\u6297\u539f\u67d3\u8272\u3002<\/p>\n

\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u901a\u8fc7NCA\u5355\u4f53\u7684\u5f00\u73af\u805a\u5408\u548c\u805a\u5408\u540e\u201c\u786b\u9187-\u70ef\u201d\u70b9\u51fb\u53cd\u5e94\u6539\u6027\uff0c\u53ef\u4ee5\u7b80\u4fbf\u5730\u5236\u5907\u4effHDPs\u7ed3\u6784\u7684\u9633\u79bb\u5b50\u5408\u6210\u805a\u591a\u80bd\u3002\u8fd9\u79cd\u9633\u79bb\u5b50\u805a\u591a\u80bd\u53ef\u79f0\u4e3aACPP\uff0c\u5728\u591a\u79cd\u80bf\u7624\u7ec6\u80de\uff08\u5305\u62ec\u8010\u836f\u6027\u548c\u9ad8\u8f6c\u79fb\u6027\u764c\u7ec6\u80de\uff09\u4e2d\u663e\u793a\u51fa\u5e7f\u8c31\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0e\u5929\u7136HDPs\u76f8\u6bd4\uff0cACPP\u5177\u6709\u66f4\u597d\u7684\u80bf\u7624\u9009\u62e9\u6027\u548c\u86cb\u767d\u9176\u7a33\u5b9a\u6027\u3002\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u9633\u79bb\u5b50ACPP\u4e3b\u8981\u901a\u8fc7\u819c\u6eb6\u89e3\u5728\u51e0\u5206\u949f\u5185\u5f15\u8d77\u764c\u7ec6\u80de\u8fc5\u901f\u574f\u6b7b\u3002\u8fd9\u79cd\u673a\u5236\u7c7b\u4f3c\u4e8eHDPs\u4ecb\u5bfc\u7684\u5fae\u751f\u7269\u6740\u706d\u8fc7\u7a0b\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63d0\u9ad8\u80bf\u7624\u9776\u5411\u6027\uff0c\u4f7f\u9633\u79bb\u5b50ACPP\u5728\u4f53\u5185\u9002\u7528\uff0c\u75282,3-\u4e8c\u7532\u57fa\u9a6c\u6765\u9178\u9150\u5bf9\u6c28\u57fa\u8fdb\u884c\u4e86\u90e8\u5206\u4fee\u9970\uff0c\u5408\u6210\u4e86ACPP\u7684\u4e24\u6027\u79bb\u5b50\u884d\u751f\u7269\uff08DA-ACPP\uff09\u3002\u7531\u4e8e\u9633\u79bb\u5b50\u7535\u8377\u964d\u4f4e\u548c\u4e24\u6027\u79bb\u5b50\u7ed3\u6784\u7684\u5f62\u6210\uff0c\u6240\u5f97DA-ACPP\u5177\u6709\u663e\u8457\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u751f\u7269\u5b89\u5168\u6027\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4e24\u6027\u79bb\u5b50DA-ACPP\u5bf9pH\u654f\u611f\uff0c\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u5728\u5f31\u9178\u6027\u80bf\u7624\u7ec4\u7ec7\u4e2d\u91cd\u65b0\u6fc0\u6d3b\u6210\u4e3a\u9633\u79bb\u5b50ACPP\uff0c\u8fc5\u901f\u6062\u590d\u6297\u764c\u6d3b\u6027\u3002\u6700\u540e\uff0c\u8fd9\u79cd\u80bf\u7624\u5fae\u73af\u5883\u53ef\u6fc0\u6d3b\u7684\u805a\u591a\u80bdDA-ACPP\u80fd\u6709\u6548\u6291\u52364T1\u539f\u4f4d\u4e73\u817a\u80bf\u7624\u548cB16-F10\u9ed1\u8272\u7d20\u7624\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u751f\u957f\uff0c\u4e14\u65e0\u660e\u663e\u526f\u4f5c\u7528\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\u8be5\u5408\u6210\u7684\u805a\u591a\u80bd\u662f\u4e00\u79cd\u6709\u6548\u7684\u6297\u764c\u6750\u6599\uff0c\u8fd9\u53ef\u80fd\u4e3a\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\u9ad8\u5206\u5b50\u6750\u6599\u7684\u5f00\u53d1\u548c\u5728\u672a\u6765\u4e34\u5e8a\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aAntineoplastic Drug\u2010Free Anticancer Strategy Enabled by Host-Defense-Peptides-Mimicking Synthetic Polypeptides<\/a> (Adv. Mater.<\/em> 2020<\/strong>, 2001108)<\/p>\n

\u8bfe\u9898\u7ec4\u7b80\u4ecb\uff1a<\/strong><\/p>\n

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