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\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

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\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001<\/strong>CaBPs<\/strong>\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09CaBPs\u7684\u5408\u6210\u793a\u610f\u56fe\u3002<\/p>\n

\uff08b-d\uff09BPs\u7684TEM\uff0cAFM\u4ee5\u53caHR-TEM\u56fe\u50cf\u3002<\/p>\n

\uff08e-g\uff09CaBPs\u7684TEM\uff0cAFM\u4ee5\u53caHR-TEM\u56fe\u50cf\u3002<\/p>\n

\uff08h\uff09CaBPs\u7684\u6697\u573a\u56fe\u50cf\u548c\u5143\u7d20\u56femapping\u3002<\/p>\n

\uff08i\uff09BPs\u548cCaBPs\u7684\u62c9\u66fc\u6563\u5c04\u5149\u8c31\u3002<\/p>\n

\uff08j\uff09CaBPs\u5728\u4e0d\u540cpH\u503c\u4e0b\u7684\u964d\u89e3\u901f\u7387\u3002<\/p>\n

\u56fe\u4e8c\u3001<\/strong>CaBPs<\/strong>\u7684\u5bf9\u8367\u5149\u7d20\u8d1f\u8f7d\u548c\u7ec6\u80de\u5185\u9012\u9001\u80fd\u529b<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09CaBPs\u5305\u5c01FITC\u8fc7\u7a0b\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08b\uff09FITC\/CaBPs\u91ca\u653eFITC\u7684\u8367\u5149\u53d1\u5c04\u5149\u8c31\uff08\u03bbex <\/sub>= 480nm\uff09\uff08FITC\/CaBPs\u6295\u6599\u6bd4\u5206\u522b\u4e3a0.4, 1, 2.5 ,5, 7.5, 10\uff09\u3002<\/p>\n

\uff08c\uff09\u4e0d\u540cFITC\/CaBPs\u6295\u6599\u6bd4\u4e0bCaBPs\u7684FITC\u8d1f\u8f7d\u91cf\uff08w\/w%\uff09\u3002<\/p>\n

\uff08d\uff09\u5728PBS\u6eb6\u6db2\u4e2d\uff0cFITC\/CaBPs\u6216FITC\/BPs\u91ca\u653e\u7684FITC\u8367\u5149\u5149\u8c31\uff08FITC\/CaBPs\u6295\u6599\u6bd4\u4e3a7.5\uff09\u3002<\/p>\n

\uff08e-f\uff09\u75284\u00b5g mL\u22121<\/sup> FITC\/CaBPs\u6216FITC\/BPs\u5904\u740612\u5c0f\u65f6\u540eMCF-7\u7ec6\u80de\u7684CLSM\u548c\u6d41\u5f0f\u7ec6\u80de\u56fe\u50cf\u5bf9\u6bd4\u3002<\/p>\n

\u56fe\u4e09\u3001<\/strong>CaBPs<\/strong>\u7684\u7279\u5f02\u6027\u6297\u764c\u6d3b\u6027<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09CaBPs\u4e0e\u6b63\u5e38\u7ec6\u80dehBMSCs\u548c\u764c\u7ec6\u80deMCF-7\u5171\u5b75\u80b224\u5c0f\u65f6\u548c48\u5c0f\u65f6\u7684\u5242\u91cf\u4f9d\u8d56\u6bd2\u6027\u3002<\/p>\n

\uff08b\uff09\u4e0d\u540c\u5242\u91cf\u4e0b\u5bf9\u5e94\u7684\u7ec6\u80de\u5468\u671f\u5206\u5e03\u3002<\/p>\n

\uff08c\uff09\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790CaBPs\u6cbb\u7597\u540ehBMSCs\u548cMCF-7\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n

\u56fe\u56db\u3001<\/strong>CaBPs<\/strong>\u8bf1\u5bfc<\/strong>MCF-7<\/strong>\u7ec6\u80de\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u53ca\u7ebf\u7c92\u4f53\u4ecb\u5bfc\u7684\u51cb\u4ea1<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u7528JC-1\u67d3\u8272\u8bc4\u4f30BPs\u6216CaBPs\u6cbb\u7597\u540eMMP\u7684\u53d8\u5316\u3002<\/p>\n

\uff08b\uff09\u901a\u8fc7\u8367\u5149ATP\u68c0\u6d4b\u5206\u6790\u7ec6\u80de\u5185ATP\u6c34\u5e73\u3002<\/p>\n

\uff08c\uff09\u7528WB\u68c0\u6d4b\u4e0d\u540c\u6d53\u5ea6CaBPs\u5bf9MCF-7\u7ec6\u80deBcl-2\u548cBax\u8868\u8fbe\u7684\u5f71\u54cd\u3002<\/p>\n

\uff08d\uff09\u7528WB\u5206\u6790\u4e0d\u540c\u5242\u91cfCaBPs\u5904\u7406\u7684MCF-7\u7ec6\u80de\u91ca\u653e\u7ec6\u80de\u8272\u7d20C\uff08Cyto C\uff09\u7684\u5f71\u54cd\u3002<\/p>\n

\uff08e\uff09\u4e0d\u540c\u6d53\u5ea6CaBPs\u5904\u7406MCF-7\u7ec6\u80de48h\u540eCaspase 3\/7\u6d3b\u6027\u3002<\/p>\n

\uff08f\uff09\u56db\u4e2a\u72ec\u7acb\u5b9e\u9a8c\u4e2d\u4e0d\u540c\u6d53\u5ea6CaBPs\u5904\u740648h\u540e\u7ec6\u80de\u5185GSH\u6c34\u5e73\u7684\u53d8\u5316\u3002<\/p>\n

\u56fe\u4e94\u3001<\/strong>CaBPs<\/strong>\u9776\u5411\u7ebf\u7c92\u4f53\u5e76\u5f15\u8d77\u7ebf\u7c92\u4f53\u7ed3\u6784\u635f\u4f24<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09CLSM\u663e\u793a\u7528CaBPs \uff082\u00b5g mL\u22121<\/sup>\uff09\u5904\u74066\u5c0f\u65f6\u548c24\u5c0f\u65f6\u7684MCF-7\u7ec6\u80de\uff0cDAPI\u67d3\u8272\u7684\u7ec6\u80de\u6838\u663e\u793a\u4e3a\u84dd\u8272\uff0cMito-Tracker\u67d3\u8272\u7684\u7ebf\u7c92\u4f53\u663e\u793a\u4e3a\u7ea2\u8272\uff0c\u7eff\u70b9\u4ee3\u8868FITC\u6807\u8bb0\u7684CABP\u3002<\/p>\n

\uff08b\uff09CaBP\u5904\u7406\u7684MCF-7\u7ec6\u80de\u7684\u900f\u5c04\u7535\u955c\u56fe\u50cf\uff0c\u5176\u4e2dN\u4ee3\u8868\u7ec6\u80de\u6838\uff0cM\u4ee3\u8868\u5065\u5eb7\u7ebf\u7c92\u4f53\uff0cDM\u8868\u793a\u7ebf\u7c92\u4f53\u53d7\u635f\u3002<\/p>\n

\u56fe\u516d\u3001<\/strong>MCF-7<\/strong>\u8377\u7624\u5c0f\u9f20\u7684\u4f53\u5185\u6297\u80bf\u7624\u4f5c\u7528\u7814\u7a76<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u6cbb\u7597\u8fc7\u7a0b\u793a\u610f\u56fe\u3002<\/p>\n

\uff08b\uff09\u5c0f\u9f20\u6cbb\u7597\u7ed3\u675f\u540e\u80bf\u7624\u7684\u7167\u7247\u3002<\/p>\n

\uff08c\uff09\u4e0d\u540c\u5904\u7406\u540e\u8377\u7624\u5c0f\u9f20\u7684\u5e73\u5747\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

\uff08d\uff09\u4ece\u5c0f\u9f20\u8eab\u4e0a\u5207\u9664\u7684\u80bf\u7624\u91cd\u91cf\u5bf9\u6bd4\u3002<\/p>\n

\uff08e\uff09\u6cbb\u7597\u671f\u95f4\u88f8\u9f20\u7684\u4f53\u91cd\u53d8\u5316\u3002<\/p>\n

\uff08f\uff09\u5c0f\u9f20\u6cbb\u7597\u540e\u4ee3\u8868\u6027\u80bf\u7624\u7ec4\u7ec7\u7684\u7ec4\u7ec7\u5b66\u663e\u5fae\u955c\u548cTUNEL\u5206\u6790\u56fe\u50cf\u3002<\/p>\n

\uff08g\uff09\u5c0f\u9f20\u6cbb\u7597\u540e\u4e3b\u8981\u5668\u5b98\u7684\u4ee3\u8868\u6027\u7ec4\u7ec7\u5b66\u663e\u5fae\u955c\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e03\u3001<\/strong>CaBPs<\/strong>\u9759\u8109\u7ed9\u836f\u5bf9\u539f\u4f4d\u4e73\u817a\u764c\u6a21\u578b\u7684\u4f53\u5185\u6297\u80bf\u7624\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09Cy5.5\/CaBPs@PPF\u6ce8\u5c04\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u5c0f\u9f20\u7684\u6d3b\u4f53\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\uff08b\uff09Cy5.5\/CaBPs@PPF\u6ce8\u5c04\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u5c0f\u9f20\u4e0d\u540c\u5668\u5b98\u7684\u79bb\u4f53\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\uff08c\uff09\uff08b\uff09\u4e2d\u8367\u5149\u5f3a\u5ea6\u7684\u91cf\u5316\u5bf9\u6bd4\u3002<\/p>\n

\uff08d\uff09\u6cbb\u7597\u8fc7\u7a0b\u793a\u610f\u56fe\u3002<\/p>\n

\uff08e\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4\u8377\u7624\u5c0f\u9f20\u7684\u5e73\u5747\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

\uff08f\uff09\u4ece\u5177\u6709\u4ee3\u8868\u6027\u7684\u5c0f\u9f20\u8eab\u4e0a\u5207\u9664\u7684\u80bf\u7624\u91cd\u91cf\u3002<\/p>\n

\uff08g\uff09\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u3002<\/p>\n

\uff08h\uff09\u5c0f\u9f20\u6cbb\u7597\u7ed3\u675f\u540e\u80bf\u7624\u7684\u7167\u7247\u3002<\/p>\n

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\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aCalcium Phosphate Mineralized Black Phosphorous with Enhanced Functionality and Anticancer Bioactivity<\/a> (Adv. Funct. Mater.<\/em> 2020<\/strong>, 2003069)<\/p>\n

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