{"id":206402,"date":"2020-08-02T06:15:26","date_gmt":"2020-08-01T22:15:26","guid":{"rendered":"\/\/m.iemloyee.com\/?p=206402"},"modified":"2020-08-01T20:29:12","modified_gmt":"2020-08-01T12:29:12","slug":"%e3%80%90ns%e7%b2%be%e8%af%bb%e3%80%91%e8%bf%9c%e7%a6%bbbad-blood%e5%bc%8f%e9%aa%97%e5%b1%80-%e5%a6%82%e4%bd%95%e5%ae%9e%e7%8e%b0%e6%bb%b4%e8%a1%80%e9%aa%8c%e7%99%8c","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=206402","title":{"rendered":"\u3010NS\u7cbe\u8bfb\u3011\u8fdc\u79bbBad Blood\u5f0f\u9a97\u5c40\u2014\u2014\u5982\u4f55\u5b9e\u73b0\u201c\u6ef4\u8840\u9a8c\u764c\u201d\uff1f"},"content":{"rendered":"<p><strong><b>\u5f15\u8a00<\/b><\/strong><\/p>\n<p>\u8fd8\u8bb0\u5f97\u51e0\u5e74\u524d\u95f9\u5f97\u6cb8\u6cb8\u626c\u626c\u7684\u201cBad Blood\u201d\u9a97\u5c40\u5417\uff1f\u4e00\u5bb6\u540d\u4e3aTheranos\u5ba3\u79f0\u53ea\u9700\u4e00\u70b9\u70b9\u8840\u6db2\u6837\u672c\u5c31\u80fd\u68c0\u6d4b\u591a\u8fbe\u6570\u5341\u79cd\u75be\u75c5\uff0c\u672a\u6765\u751a\u81f3\u80fd\u6709\u671b\u9ad8\u6548\u68c0\u6d4b\u8840\u6db2\u4e2d\u7684\u764c\u75c7\u6807\u5fd7\u7269\u3002\u7136\u800c\uff0c\u968f\u7740\u6570\u636e\u7684\u4e0d\u65ad\u62ab\u9732\uff0c\u4eba\u4eec\u6e10\u6e10\u53d1\u73b0\u8fd9\u79cd\u68c0\u6d4b\u65b9\u5f0f\u975e\u5e38\u4e0d\u53ef\u9760\uff0c\u53d6\u8840\u91cf\u8fdc\u8fdc\u4e0d\u80fd\u6ee1\u8db3\u68c0\u6d4b\u9650\u9700\u6c42\uff0c\u968f\u540e\u539f\u672c\u524d\u666f\u65e0\u9650\u7684Theranos\u516c\u53f8\u906d\u9047\u8d44\u672c\u5371\u673a\uff0c\u5982\u4eca\u5df2\u9eef\u7136\u8fdc\u79bb\u4eba\u4eec\u7684\u89c6\u91ce\u3002\u7136\u800c\uff0c\u201c\u6ef4\u8840\u9a8c\u764c\u201d\u771f\u7684\u65e0\u6cd5\u5b9e\u73b0\u5417\uff1f\u8840\u7cd6\u4eea\u662f\u4e00\u6b3e\u975e\u5e38\u7ecf\u5178\u7684\u75be\u75c5\u68c0\u6d4b\u5668\u4ef6\uff0c\u53ea\u9700\u4e00\u70b9\u6307\u5c16\u8840\uff0c\u5c31\u80fd\u6d4b\u91cf\u4eba\u4f53\u8840\u7cd6\u6c34\u5e73\u3002\u4f46\u662f\u5bf9\u4e8e\u50cf\u764c\u75c7\u8fd9\u7c7b\u91cd\u5927\u75be\u75c5\u6765\u8bf4\uff0c\u5355\u4e00\u7684\u68c0\u6d4b\u6307\u6807\u5f88\u96be\u4f5c\u4e3a\u5224\u65ad\u4f9d\u636e\uff0c\u56e0\u6b64\u591a\u91cd\u9176\u68c0<a href=\"\/\/m.iemloyee.com\/?p=206402&amp;preview=true\">\u9884\u89c8 \uff08\u5728\u65b0\u7a97\u53e3\u4e2d\u6253\u5f00\uff09<\/a>\u6d4b\uff08multiplexed enzymatic detection\uff09\u5fc5\u4e0d\u53ef\u5c11\u3002<\/p>\n<p style=\"text-align: center;\">\u00a0<\/p>\n<p>\u7136\u800c\uff0c\u7531\u4e8e\u9176\u7684\u6700\u4f18\u6d3b\u6027\u6761\u4ef6\u5404\u4e0d\u76f8\u540c\uff0c\u591a\u91cd\u68c0\u6d4b\u7684\u5b9e\u73b0\u4e00\u76f4\u662f\u4e00\u4e2a\u8270\u5de8\u7684\u79d1\u5b66\u4efb\u52a1\u3002\u867d\u7136\u8fd1\u5e74\u6765\uff0c\u57fa\u4e8e\u751f\u7269\u5927\u5206\u5b50\u4eb2\u548c\u80fd\u529b\u7684\u7535\u5316\u5b66\u751f\u7269\u4f20\u611f\u5668\u5728\u591a\u91cd\u9176\u68c0\u6d4b\u5df2\u53d6\u5f97\u8bb8\u591a\u7814\u7a76\u8fdb\u5c55\uff0c\u4f46\u662f\u5176\u5546\u4e1a\u5316\u524d\u666f\u4f9d\u7136\u4e0d\u660e\u3002\u6700\u4e3b\u8981\u7684\u539f\u56e0\u662f\u7535\u5316\u5b66\u751f\u7269\u4f20\u611f\u662f\u57fa\u4e8e\u7531\u7535\u6781\u3001\u6837\u54c1\u7b49\u7ec4\u6210\u7684\u95ed\u73af\u7535\u5b66\u7535\u8def\uff0c\u6837\u54c1\u4e2d\u7684\u751f\u7269\u6807\u8bb0\u7269\u7ec4\u5206\uff08\u5927\u591a\u4e3a\u975e\u68c0\u6d4b\u76f8\u5173\u86cb\u767d\u8d28\uff09\u4f1a\u4e0e\u7535\u6781\u8fdb\u884c\u975e\u7279\u5f02\u6027\u7ed3\u5408\u5e76\u6c61\u67d3\u7535\u6781\uff0c\u4ece\u800c\u51cf\u5f31\u7535\u6d41\u548c\u7075\u654f\u5ea6\u3002\u800c\u4f20\u7edf\u7684\u9632\u6c61\u6d82\u5c42\uff0c\u5982\u725b\u8840\u6e05\u767d\u86cb\u767d\uff08BSA\uff09\u548c\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u81ea\u7ec4\u88c5\u5355\u5c42\u867d\u7136\u53ef\u4ee5\u9632\u6b62\u7535\u6781\u6c61\u67d3\uff0c\u4f46\u4e5f\u4f1a\u963b\u788d\u7535\u5b50\u8f93\u8fd0\uff0c\u4f7f\u5f97\u9632\u6c61\u7b56\u7565\u9677\u5165\u4e24\u96be\u7684\u5883\u5730\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u53ef\u9760\u7684\u9632\u6c61\u7b56\u7565\u662f\u7535\u5316\u5b66\u751f\u7269\u4f20\u611f\u5668\u7ee7\u7eed\u53d1\u5c55\u6240\u4e9f\u9700\u89e3\u51b3\u7684\u6311\u6218\u3002\u8fd1\u671f\uff0c<strong><b>\u54c8\u4f5b\u5927\u5b66\u8457\u540d\u7684\u4eff\u751f\u5de5\u7a0b\u5b66\u5bb6<\/b><\/strong><strong><b>Donald E. Ingber<\/b><\/strong>\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u901a\u8fc7\u6539\u9020\u7535\u6781\u53ef\u4ee5\u6709\u6548\u9632\u6b62\u86cb\u767d\u8d28\u6c61\u67d3\uff0c\u5728\u957f\u8fbe\u4e00\u4e2a\u6708\u7684\u8840\u6db2\u68c0\u6d4b\u4e2d\u4ecd\u7136\u53ef\u4ee5\u7ef4\u6301\u4f20\u611f\u5668\u4f18\u5f02\u68c0\u6d4b\u6027\u80fd\u3002\u8be5\u7bc7\u7814\u7a76\u6587\u7ae0\u9898\u4e3a\u201cAn antifouling coating that enables affinity-based\u00a0electrochemical biosensing in complex biological\u00a0fluids\u201d\uff0c\u4e8e2019\u5e7411\u670811\u65e5\u53d1\u8868\u4e8e<strong><em><b><i>Nature Nanotechnology<\/i><\/b><\/em><\/strong>\u3002<\/p>\n<p><strong><b><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-206404 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/\u56fe\u72472-53.png\" alt=\"\" width=\"600\" height=\"231\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/\u56fe\u72472-53.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/\u56fe\u72472-53-300x116.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/b><\/strong><\/p>\n<p style=\"text-align: center;\"><strong><b>\u54c8\u4f5b\u56e2\u961f\u5728Nature Nanotechnology\u53d1\u8868\u7684\u5173\u4e8e\u751f\u7269\u4f20\u611f\u5668\u7684\u6700\u65b0\u6587\u7ae0<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><\/p>\n<p><strong><b>\u9632\u6c61\u7535\u6781\u5236\u5907<\/b><\/strong><\/p>\n<p>\u9996\u5148\uff0c\u8ba9\u6211\u4eec\u6765\u770b\u770b\u5728\u8fd9\u9879\u5de5\u4f5c\u65b0\u578b\u9632\u6c61\u7535\u6781\u662f\u5982\u4f55\u5236\u5907\u7684\u3002\u5982\u56fe1a-1c\u6240\u793a\uff0c\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u4e86\u4e00\u79cd\u7531BSA\u548c\u5bfc\u7535\u7eb3\u7c73\u6750\u6599\uff08\u91d1\u7eb3\u7c73\u7ebf\u3001\u91d1\u7eb3\u7c73\u9897\u7c92\u6216\u8005\u78b3\u7eb3\u7c73\u7ba1\uff09\u4ea4\u9519\u800c\u6210\u7684\u4e09\u7ef4\u7eb3\u7c73\u590d\u5408\u6750\u6599\u3002\u901a\u8fc7\u6df7\u5408\u4ee5\u53ca\u8d85\u58f0-\u79bb\u5fc3\u4f5c\u7528\u6765\u5747\u5316\u7eb3\u7c73\u590d\u5408\u6750\u6599\uff0c\u518d\u5229\u7528\u6ef4\u6d82\u6cd5\uff08drop-casting\uff09\u5c06\u7eb3\u7c73\u590d\u5408\u6750\u6599\u6ef4\u6d82\u5230\u91d1\u7535\u6781\u82af\u7247\u8868\u9762\u5f62\u6210\u9632\u6c61\u6d82\u5c42\u3002\u7531\u6b64\u5236\u5f97\u7684\u7535\u6781\u5728\u7535\u5316\u5b66\u6d3b\u6027\u7684\u4e09\u94c1\u6c30\u5316\u94be\uff08potassium ferriferrocyanide\uff09\u6eb6\u6db2\u8fdb\u884c\u5faa\u73af\u4f0f\u5b89\u6cd5\u68c0\u6d4b\u3002\u5176\u4e2d\uff0c\u8fd8\u539f\u5cf0\u548c\u6c27\u5316\u5cf0\u4e4b\u95f4\u7684\u7535\u4f4d\u5dee\u503c\u0394Ep\u548c\u7535\u6d41\u5bc6\u5ea6\u53ef\u4ee5\u8bc4\u4ef7\u7535\u6781\u8868\u9762\u548c\u6eb6\u6db2\u4e4b\u95f4\u7684\u7535\u5b50\u8f93\u8fd0\u52a8\u529b\u5b66\uff0c\u4ece\u800c\u53cd\u6620\u4f20\u611f\u5668\u56fa\u6db2\u754c\u9762\u7684\u72b6\u6001\u548c\u8d28\u91cf\u3002\u5982\u56fe1d-1e\u6240\u793a\uff0c BSA\u548cBSA\/\u91d1\u7eb3\u7c73\u7ebf\u6d82\u5c42\u90fd\u4f1a\u949d\u5316\u7535\u6781\uff0c\u800cBSA\/\u91d1\u7eb3\u7c73\u9897\u7c92\u548cBSA\/\u78b3\u7eb3\u7c73\u7ba1\u6d82\u5c42\u5219\u80fd\u5206\u522b\u4fdd\u755925%\u548c75%\u7684\u7535\u6d41\u5bc6\u5ea6\uff0c\u8868\u660e\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u6709\u6548\u4ecb\u5bfc\u7535\u5b50\u8f93\u8fd0\u3002\u5f53\u7535\u6781\u4e0e\u542b1%\u7684BSA\u7f13\u51b2\u6db2\u4e00\u8d77\u5b75\u80b2\uff081-d\uff0c\u4e00\u5929\uff09\u4ee5\u6d4b\u8bd5\u7535\u6781\u9632\u6c61\u6027\u80fd\u65f6\uff0c\u9664\u4e86BSA\/\u78b3\u7eb3\u7c73\u7ba1\u6d82\u5c42\u7535\u6781\u5916\u6240\u6709\u7535\u6781\u7684\u7535\u5316\u5b66\u6027\u80fd\u90fd\u7ecf\u5386\u4e86\u8870\u9000\uff1b\u5176\u4e2d\uff0cBSA\/\u91d1\u7eb3\u7c73\u9897\u7c92\u6d82\u5c42\u7535\u6781\u8868\u73b0\u51fa\u5bbd\u8fbe0.4V\u7684\u7535\u4f4d\u5dee\u503c\uff0c\u8bf4\u660e\u7531\u4e8e\u751f\u7269\u6c61\u67d3\u9020\u6210\u6eb6\u6db2\u4e2d\u94c1\u6c30\u6839\u79bb\u5b50\u81f3\u7535\u6781\u8868\u9762\u7684\u6269\u6563\u53d7\u5230\u9650\u5236\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e00\u6269\u6563\u9650\u5236\u95ee\u9898\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u620a\u4e8c\u919b\u6dfb\u52a0\u5230\u7eb3\u7c73\u590d\u5408\u6750\u6599\u4e2d\u7528\u4ee5\u4ea4\u8054BSA\u5206\u5b50\uff0c\u4ece\u800c\u5f62\u6210\u5e03\u6ee1\u5bfc\u7535\u7eb3\u7c73\u6750\u6599\u7684\u591a\u5b54\u4e09\u7ef4\u86cb\u767d\u8d28\u57fa\u8d28\u3002\u5728BSA\/\u91d1\u7eb3\u7c73\u9897\u7c92\/\u620a\u4e8c\u919b\u6d82\u5c42\u4e2d\u4f9d\u7136\u51fa\u73b0\u660e\u663e\u7684\u7535\u6781\u949d\u5316\uff0c\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u91d1\u7eb3\u7c73\u9897\u7c92\u80fd\u591f\u5835\u585e\u57fa\u8d28\u5b54\u3002\u7136\u800c\uff0c\u5728\u5176\u4ed6\u7535\u6781\u4e2d\uff0c\u4ea4\u8054\u4e86\u620a\u4e8c\u919b\u4e4b\u540e\u7684\u7535\u5316\u5b66\u6027\u80fd\u90fd\u80fd\u5f97\u5230\u660e\u663e\u7684\u63d0\u5347\u3002\u7279\u522b\u662f\uff0cBSA\/\u91d1\u7eb3\u7c73\u7ebf\/\u620a\u4e8c\u919b\u6d82\u5c42\u7535\u6781\u80fd\u591f\u89c2\u5bdf\u5230\u5177\u6709\u4e0e\u88f8\u91d1\u7535\u6781\u76f8\u4f3c\u7684\u7535\u5316\u5b66\u884c\u4e3a\uff08\u56fe1f-1g\uff09\u3002<\/p>\n<p><strong><b><img 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Nanotech. 2019, 1089-1090.\uff09<\/p>\n<p><strong><b>\u7ed3\u8bba<\/b><\/strong><\/p>\n<p>\u867d\u7136\u8fd1\u5e74\u6765\u7535\u6781\u7684\u9632\u6c61\u7814\u7a76\u8fdb\u5c55\u4e0d\u5c11\uff0c\u4f46\u662f\u8fd9\u7bc7\u6587\u7ae0\u63d0\u51fa\u7684\u7535\u6781\u5236\u5907\u65b9\u6cd5\u5374\u5f02\u5e38\u7b80\u5355\uff0c\u53ea\u9700\u5c06\u590d\u5408\u6df7\u5408\u7269\u8fdb\u884c\u6ef4\u6d82\u5373\u53ef\u3002\u6d82\u5c42\u57fa\u8d28\u4e2d\u7684BSA\u9aa8\u67b6\u80fd\u591f\u963b\u6b62\u975e\u7279\u5f02\u6027\u86cb\u767d\u5438\u9644\uff0c\u540c\u65f6\u5141\u8bb8\u53ef\u6eb6\u6027\u7684\u7535\u6d3b\u6027\u7269\u79cd\u80fd\u591f\u6700\u5927\u9650\u5ea6\u5730\u6269\u6563\u5230\u7535\u6781\u5468\u56f4\u3002\u6700\u7ec8\uff0c\u91d1\u7535\u6781\u5728\u6d82\u8986BSA\/\u91d1\u7eb3\u7c73\u7ebf\/\u620a\u4e8c\u919b\u7eb3\u7c73\u590d\u5408\u6d82\u5c42\u540e\u7535\u6d41\u5bc6\u5ea6\u53ef\u4ee5\u4fdd\u755988%\u4ee5\u4e0a\uff0c\u5728\u50a8\u5b58\u671f\u957f\u8fbe\u4e00\u4e2a\u6708\u5de6\u53f3\u7684\u6761\u4ef6\u4e0b\u4fe1\u53f7\u635f\u5931\u503c\u53ea\u670910%\u5de6\u53f3\uff0c\u8bc1\u660e\u8fd9\u4e00\u9632\u6c61\u7b56\u7565\u662f\u5207\u5b9e\u9ad8\u6548\u7684\u3002<\/p>\n<p><strong><b>\u53c2\u8003\u6587\u732e\uff1a<\/b><\/strong>An antifouling coating that enables affinity-based\u00a0electrochemical biosensing in complex biological\u00a0fluids<\/p>\n<p><strong><b>\u6587\u732e\u94fe\u63a5\uff1a<\/b><\/strong>https:\/\/www.nature.com\/articles\/s41565-019-0566-z<\/p>\n<p>\u672c\u6587\u7531nanoCJ\u4f9b\u7a3f\u3002<\/p>\n<p>\u672c\u5185\u5bb9\u4e3a\u4f5c\u8005\u72ec\u7acb\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u6750\u6599\u4eba\u7f51\u7acb\u573a\u3002<\/p>\n<p>\u672a\u7ecf\u5141\u8bb8\u4e0d\u5f97\u8f6c\u8f7d\uff0c\u6388\u6743\u4e8b\u5b9c\u8bf7\u8054\u7cfbkefu@cailiaoren.com\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1: tougao@cailiaoren.com.<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenVIP\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5f15\u8a00 \u8fd8\u8bb0\u5f97\u51e0\u5e74\u524d\u95f9\u5f97\u6cb8\u6cb8\u626c\u626c\u7684\u201cBad Blood\u201d\u9a97\u5c40\u5417\uff1f\u4e00\u5bb6\u540d\u4e3aTheranos\u5ba3\u79f0\u53ea\u9700\u4e00\u70b9\u70b9\u8840\u6db2\u6837\u672c\u5c31\u80fd\u68c0\u6d4b\u591a\u8fbe\u6570\u5341\u79cd\u75be\u75c5\uff0c\u672a\u6765\u751a\u81f3\u80fd\u6709\u671b\u9ad8\u6548\u68c0\u6d4b\u8840\u6db2\u4e2d&#8230;<\/p>\n","protected":false},"author":11454,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1187],"tags":[],"class_list":["post-206402","post","type-post","status-publish","format-standard","hentry","category-zhuanlan"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/206402"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/11454"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=206402"}],"version-history":[{"count":2,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/206402\/revisions"}],"predecessor-version":[{"id":206672,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/206402\/revisions\/206672"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=206402"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=206402"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=206402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}