{"id":206214,"date":"2020-08-09T06:07:07","date_gmt":"2020-08-08T22:07:07","guid":{"rendered":"\/\/m.iemloyee.com\/?p=206214"},"modified":"2020-08-08T22:07:23","modified_gmt":"2020-08-08T14:07:23","slug":"%e7%be%8e%e5%9b%bd%e8%a5%bf%e5%8c%97%e5%a4%a7%e5%ad%a6chad-a-mirkin-j-am-chem-soc-%ef%bc%9a%e7%94%a8%e4%ba%8e%e6%b4%bb%e7%bb%86%e8%83%9e%e5%8c%96%e5%ad%a6%e5%88%86%e6%9e%90%e7%9a%84%e8%9b%8b","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=206214","title":{"rendered":"\u7f8e\u56fd\u897f\u5317\u5927\u5b66Chad A. Mirkin J. Am. Chem. Soc.\uff1a\u7528\u4e8e\u6d3b\u7ec6\u80de\u5316\u5b66\u5206\u6790\u7684\u86cb\u767d\u8d28\u7403\u5f62\u6838\u9178"},"content":{"rendered":"<p>\u3010<strong>\u5f15\u8a00<\/strong>\u3011<\/p>\n<p>\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5bf9\u6d3b\u7ec6\u80de\u8fdb\u884c\u5316\u5b66\u5206\u6790\u53ef\u63d0\u4f9b\u5bf9\u52a8\u6001\u7ec6\u80de\u8fc7\u7a0b\u7684\u57fa\u672c\u4e86\u89e3\uff0c\u4e86\u89e3\u7ec6\u80de\u5185\u5206\u6790\u7269\u5728\u75be\u75c5\u8fdb\u5c55\u4e2d\u7684\u4f5c\u7528\uff0c\u5e76\u6307\u5bfc\u4e86\u65b0\u7684\u533b\u5b66\u8bca\u65ad\u5de5\u5177\u7684\u5f00\u53d1\u3002\u5c3d\u7ba1\u57fa\u4e8e\u5206\u5b50\u8bc6\u522b\uff08\u57fa\u4e8e\u7ed3\u5408\u7684\u4f20\u611f\uff09\u548c\u5206\u5b50\u53cd\u5e94\u6027\uff08\u57fa\u4e8e\u6d3b\u6027\u7684\u4f20\u611f\uff09\u7684\u8367\u5149\u63a2\u9488\u5df2\u7ecf\u5e26\u6765\u4e86\u663e\u7740\u7684\u65b0\u529f\u80fd\uff0c\u4f46\u662f\u5927\u591a\u6570\u6280\u672f\u90fd\u9700\u8981\u56fa\u5b9a\u6216\u88c2\u89e3\u7ec6\u80de\uff0c\u4f7f\u7528\u7ec6\u80de\u6bd2\u6027\u8f6c\u67d3\u8bd5\u5242\uff0c\u6216\u7ec6\u80de\u7684\u9057\u4f20\u7f16\u7801\u3002\u5177\u4f53\u6765\u8bf4\uff0c\u901a\u5e38\u4f7f\u7528\u57fa\u4e8e\u86cb\u767d\u8d28\u548c\u6838\u9178\u7684\u65b9\u6cd5\uff08\u4f8b\u5982\u9176\u8054\u514d\u75ab\u5438\u9644\u6d4b\u5b9a\uff0c\u9057\u4f20\u7f16\u7801\u7684\u8367\u5149\u86cb\u767d\u548cRNA\u4f20\u611f\u5668\uff0c\u805a\u5408\u9176\u94fe\u53cd\u5e94\u548c\u8367\u5149\u539f\u4f4d\u6742\u4ea4\uff09\u6765\u68c0\u6d4b\u591a\u79cd\u751f\u7269\u5206\u6790\u7269\u3002\u7136\u800c\uff0c\u5916\u6e90\u86cb\u767d\u8d28\u548c\u6838\u9178\u6ca1\u6709\u88ab\u7ec6\u80de\u6709\u6548\u5730\u5185\u5728\u5316\u3002\u56e0\u6b64\uff0c\u5c06\u5b83\u4eec\u53d1\u5c55\u6210\u6d3b\u7ec6\u80de\u7ec6\u80de\u5185\u63a2\u9488\u662f\u5177\u6709\u6311\u6218\u6027\u7684\u3002<\/p>\n<p>\u3010<strong>\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n<p><strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong><strong>\u7f8e\u56fd\u897f\u5317\u5927\u5b66\u7684<\/strong><strong>Chad A. Mirkin<\/strong>\u62a5\u9053\u4e86\u57fa\u4e8e\u86cb\u767d\u8d28\u7403\u5f62\u6838\u9178\uff08ProSNAs\uff09\u7684\u6d3b\u7ec6\u80de\u5316\u5b66\u5206\u6790\u65b0\u7b56\u7565\u7684\u53d1\u5c55\u3002ProSNA\u4f53\u7cfb\u7ed3\u6784\u53ef\u901a\u8fc7\u9ad8\u5ea6\u53ef\u7f16\u7a0b\u7684\u6838\u9178\u5916\u58f3\u6216\u529f\u80fd\u86cb\u767d\u6838\u5fc3\u5b9e\u73b0\u5206\u6790\u7269\u68c0\u6d4b\u3002\u4f5c\u4e3a\u6982\u5ff5\u9a8c\u8bc1\uff0c\u4f5c\u8005\u4f7f\u7528i-\u57fa\u5e8f\u4f5c\u4e3a\u6838\u9178\u8bc6\u522b\u5143\u4ef6\u6765\u63a2\u6d4b\u6d3b\u7ec6\u80de\u4e2d\u7684pH\u3002\u901a\u8fc7\u5c06i-\u57fa\u5e8f\u4e0e\u5f3a\u5236\u63d2\u5165\u8bfb\u6570\u63a5\u53e3\uff0c\u4f5c\u8005\u5f15\u5165\u4e86\u4e00\u79cd\u65e0\u731d\u706d\u5242\u7684\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u53ef\u62b5\u6297\u5047\u9633\u6027\u4fe1\u53f7\uff0c\u4ece\u800c\u514b\u670d\u4e86\u4e0e\u5e38\u89c4\u8367\u5149\u7d20\/\u731d\u706d\u5242\u57fa\u7684\u91d1\u7eb3\u7c73\u706b\u70ac\u76f8\u5173\u7684\u5c40\u9650\u6027\u3002\u4f7f\u7528\u8461\u8404\u7cd6\u6c27\u5316\u9176\u4f5c\u4e3a\u529f\u80fd\u6027\u86cb\u767d\u6838\u5fc3\uff0c\u663e\u793a\u4e86\u57fa\u4e8e\u6d3b\u6027\u7684\u8461\u8404\u7cd6\u653e\u5927\u4f20\u611f\u3002\u8fd9\u79cd\u9176\u4fc3\u7cfb\u7edf\u7684\u8367\u5149\u5f00\u542f\u7387\u5927\u4e8e100\u500d\uff0c\u5728\u5b58\u5728\u7c7b\u4f3c\u7269\u7684\u60c5\u51b5\u4e0b\u5bf9\u8461\u8404\u7cd6\u5177\u6709\u9009\u62e9\u6027\uff0c\u5e76\u4e14\u53ef\u4ee5\u68c0\u6d4b\u5230\u9ad8\u4e8e\u7ea65\u03bcM\u9608\u503c\u6d53\u5ea6\u7684\u8461\u8404\u7cd6\u3002\u7ec6\u80de\u5185\u8461\u8404\u7cd6\u6d53\u5ea6\u76f8\u5bf9\u53d8\u5316\u7684\u7814\u7a76\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201cProtein Spherical Nucleic Acids for Live-Cell Chemical Analysis\u201d<\/strong>\u53d1\u8868\u5728<strong>J. Am. Chem. Soc.<\/strong><strong>\u4e0a<\/strong>\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe<\/strong><strong>1.<\/strong><strong>\u63a2\u9488\u7684\u7ed3\u6784\u4ee5\u53ca\u5de5\u4f5c\u673a\u7406<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-206215\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r1-7.jpg\" alt=\"\" width=\"600\" height=\"776\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r1-7.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r1-7-232x300.jpg 232w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u5e26\u6709\u8d56\u6c28\u9178\u548c\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\u7684\u03b2-\u534a\u4e73\u7cd6\u82f7\u9176\u7684\u7ed3\u6784\u7a81\u51fa<\/p>\n<p>\uff08B\uff09\u5f3a\u5236\u63d2\u5165\u67d3\u6599\u567b\u5511\u6a59\u7684\u7ed3\u6784\uff0cTO\uff08\u7fa7\u7532\u57fa\u5316\u884d\u751f\u7269\uff09<\/p>\n<p>\uff08C\uff09\u7528TO\u53d6\u4ee3\u5355\u4e2a\u78b1\u57fa\u7684i-\u57fa\u5e8f\u5e8f\u5217<\/p>\n<p>\uff08D\uff09\u6298\u53e0\u7684i-\u57fa\u5e8f\uff0c\u5728\u57fa\u5bf9\u4e4b\u95f4\u63d2\u5165TO<\/p>\n<p>\uff08E\uff09\u5728pH 7.5\u548cpH 5.5\u7684ProTOn\u7684\u7ed3\u6784\u3002i-\u57fa\u5e8f\u7ed3\u6784\u7684\u5f62\u6210\u5bfc\u81f4TO\u7684\u8367\u5149\u5f00\u542f<\/p>\n<p><strong>\u56fe<\/strong><strong>2.<\/strong><strong>\u63a2\u9488\u7684<\/strong><strong>pH<\/strong><strong>\u54cd\u5e94<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-206216\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r2-7.jpg\" alt=\"\" width=\"600\" height=\"204\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r2-7.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r2-7-300x102.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09ProTOn\u548c\u5bf9\u7167\u63a2\u9488\u7684\u4f53\u5916\u8367\u5149\u54cd\u5e94\u968fpH\u7684\u53d8\u5316<\/p>\n<p>\uff08B\uff09\u7528ProTOn\u548c\u5bf9\u7167\u63a2\u9488\u5904\u7406\u7684MDA-MB-231\u7ec6\u80de\u7684TO\u901a\u9053\u8367\u5149\u54cd\u5e94<\/p>\n<p><strong>\u56fe<\/strong><strong>3.<\/strong><strong>\u7ed3\u6784\u4e0e\u5de5\u4f5c\u673a\u7406<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-206217\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r3-6.jpg\" alt=\"\" width=\"600\" height=\"413\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r3-6.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r3-6-300x207.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u8461\u8404\u7cd6\u6c27\u5316\u9176SNA\uff08GOx-SNA\uff09\u7684\u7ed3\u6784<\/p>\n<p>\uff08B\uff09\u8367\u5149\u7d20\u53cc\uff08\u82c4\u57fa\u787c\u9178\u916f\uff09\uff0cFBBBE\u7684\u7ed3\u6784<\/p>\n<p>\uff08C\uff09\u4e3a\u8461\u8404\u7cd6\u68c0\u6d4b\u5f00\u53d1\u7684\u4e24\u6b65\u6d4b\u5b9a\u6cd5\u3002\uff08i\uff09\u9996\u5148\uff0cGOx-SNAs\u50ac\u5316\u03b2-D-\u8461\u8404\u7cd6\u5411D-\u8461\u8404\u7cd6\u57fa1,5-\u5185\u916f\u7684\u8f6c\u5316\uff0c\u5e76\u5f62\u6210H2O2\uff1b\uff08ii\uff09\u751f\u6210\u7684H2O2\u4e0e\u975e\u8367\u5149FBBBE\u53cd\u5e94\uff0c\u5e76\u4ea7\u751f\u9ad8\u5ea6\u8367\u5149\u7684\u8367\u5149\u7d20<\/p>\n<p><strong>\u56fe<\/strong><strong>4.<\/strong><strong>\u4f53\u5916\u5b9e\u9a8c<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-206218\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r4-6.jpg\" alt=\"\" width=\"600\" height=\"539\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r4-6.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/07\/r4-6-300x270.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09GOx-SNA\u5bf9\u8461\u8404\u7cd6\u6d53\u5ea6\u589e\u52a0\u7684\u4f53\u5916\u8367\u5149\u53cd\u5e94<\/p>\n<p>\uff08B\uff09GOx-SNA\u5bf9\u5176\u4ed6\u7cd6\u7c7b\u7684\u4f53\u5916\u9009\u62e9\u6027<\/p>\n<p>\uff08C\uff09\u4e0d\u540c\u5904\u7406\u6761\u4ef6\u4e0bEL4\u7ec6\u80de\u7684\u8367\u5149<\/p>\n<p>\uff08D\uff09\u5bf9\u5e94\u4e8e\uff08C\uff09\u4e2d\u6570\u636e\u7684\u4ee3\u8868\u6027\u8367\u5149\u76f4\u65b9\u56fe<\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n<p>\u603b\u4e4b\uff0c\u4f5c\u8005\u57fa\u4e8eProSNAs\u5f00\u53d1\u4e86\u529f\u80fd\u5f3a\u5927\u7684\u65b0\u578b\u7ec6\u80de\u5185\u63a2\u9488\u3002 \u5b83\u4eec\u7684\u6a21\u5757\u5316\u7ed3\u6784\u5141\u8bb8\u4eba\u4eec\u72ec\u7acb\u5730\u6539\u53d8\u86cb\u767d\u8d28\u6838\u5fc3\u548c\u6838\u9178\u5916\u58f3\uff0c\u5e76\u901a\u8fc7\u57fa\u4e8e\u7ed3\u5408\u6216\u57fa\u4e8e\u6d3b\u6027\u7684\u4f20\u611f\uff0c\u4f7f\u7528\u4efb\u4e00\u7ec4\u5206\u4f5c\u4e3a\u4f20\u611f\u90e8\u5206\u6765\u68c0\u6d4b\u5206\u6790\u7269\u3002\u6838\u9178\u7684\u53ef\u7f16\u7a0b\u6027\u8d28\u539f\u5219\u4e0a\u5c06\u5141\u8bb8\u4f7f\u7528\u9002\u4f53\uff0cDNA\u9176\u6216\u57fa\u4e8e\u6742\u4ea4\u7684\u63a2\u9488\u68c0\u6d4b\u9776\u6807\u3002\u86cb\u767d\u8d28\u65e0\u4e0e\u4f26\u6bd4\u7684\u7279\u5f02\u6027\u5c06\u4ea7\u751f\u5bf9\u76ee\u6807\u5177\u6709\u9ad8\u5ea6\u9009\u62e9\u6027\u7684\u63a2\u9488\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5<\/strong>\uff1aProtein Spherical Nucleic Acids for Live-Cell Chemical Analysis. <em>J. Am. Chem. Soc., <\/em><strong>2020<\/strong>, DOI: 10.1021\/jacs.0c06866<\/p>\n<p>\u672c\u6587\u7531tt\u4f9b\u7a3f\u3002\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5bf9\u6d3b\u7ec6\u80de\u8fdb\u884c\u5316\u5b66\u5206\u6790\u53ef\u63d0\u4f9b\u5bf9\u52a8\u6001\u7ec6\u80de\u8fc7\u7a0b\u7684\u57fa\u672c\u4e86\u89e3\uff0c\u4e86\u89e3\u7ec6\u80de\u5185\u5206\u6790\u7269\u5728\u75be\u75c5\u8fdb\u5c55\u4e2d\u7684\u4f5c\u7528\uff0c\u5e76\u6307\u5bfc\u4e86\u65b0\u7684\u533b\u5b66\u8bca\u65ad\u5de5\u5177\u7684\u5f00\u53d1\u3002\u5c3d\u7ba1\u57fa\u4e8e\u5206\u5b50\u8bc6\u522b\uff08&#8230;<\/p>\n","protected":false},"author":7336,"featured_media":206215,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[4344],"class_list":["post-206214","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-4344"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/206214"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=206214"}],"version-history":[{"count":2,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/206214\/revisions"}],"predecessor-version":[{"id":207120,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/206214\/revisions\/207120"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/206215"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=206214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=206214"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=206214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}