{"id":206065,"date":"2020-08-08T06:39:50","date_gmt":"2020-08-07T22:39:50","guid":{"rendered":"\/\/m.iemloyee.com\/?p=206065"},"modified":"2020-08-07T22:25:27","modified_gmt":"2020-08-07T14:25:27","slug":"%e5%af%86%e8%8b%8f%e9%87%8c%e5%a4%a7%e5%ad%a6%e5%a0%aa%e8%90%a8%e6%96%af%e5%88%86%e6%a0%a1%e7%a8%8b%e5%9d%a4sci-adv-%ef%bc%9a%e6%9d%82%e5%90%88%e7%ba%b3%e7%b1%b3%e5%a4%8d%e5%90%88%e7%89%a9%e5%85%b1","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=206065","title":{"rendered":"\u5bc6\u82cf\u91cc\u5927\u5b66\u582a\u8428\u65af\u5206\u6821\u7a0b\u5764Sci. Adv\uff1a\u6742\u5408\u7eb3\u7c73\u590d\u5408\u7269\u5171\u540c\u9012\u9001IKBKE siRNA\u548c\u5361\u5df4\u4ed6\u8d5b\u53ef\u6291\u5236\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u4fb5\u88ad\u6027\u548c\u751f\u957f"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u88ab\u5b9a\u4e49\u4e3a\u7f3a\u4e4f\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08ER\uff09\uff0c\u5b55\u6fc0\u7d20\u53d7\u4f53\uff08PR\uff09\u548c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u7684\u8868\u8fbe\uff0c\u7ea6\u5360\u6240\u6709\u4e73\u817a\u764c\u768412\uff05\u81f317\uff05\u3002TNBC\u6bd4\u975eTNBC\u66f4\u5177\u4fb5\u7565\u6027\uff0c\u589e\u6b96\u6027\uff0c\u96be\u4ee5\u9884\u6d4b\u4e14\u751f\u5b58\u7387\u8f83\u5dee\u3002\u6838\u56e0\u5b50\u6d3b\u5316B\u7ec6\u80de\u03ba\u8f7b\u94fe\u589e\u5f3a\u5b50\uff08NF-\u03baB\uff09\u662fTNBC\u4e2d\u7684\u5173\u952e\u8c03\u8282\u5242\u3002\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\uff0cNF-\u03baB\u4f4d\u4e8e\u7ec6\u80de\u8d28\u4e2d\u4e14\u4e0e\u6291\u5236\u86cb\u767dI\u03baB\u7ed3\u5408\u5f62\u6210\u590d\u5408\u4f53\uff1b \u5728\u764c\u7ec6\u80de\u4e2d\uff0cI\u03baB\u6fc0\u9176\uff08IKKs\uff09\u88ab\u6fc0\u6d3b\u5e76\u8f6c\u800c\u78f7\u9178\u5316I\u03baBs\u5e76\u8bf1\u5bfc\u5176\u964d\u89e3\uff0c\u4ece\u800c\u5bfc\u81f4NF-\u03baB\u6613\u4f4d\u81f3\u7ec6\u80de\u6838\u5185\u3002\u6fc0\u6d3b\u7684NF-\u03baB\u4fe1\u53f7\u901a\u8def\u663e\u8457\u589e\u5f3a\u4e86\u4e73\u817a\u764c\uff0c\u5c24\u5176\u662fER\u9634\u6027\u4e73\u817a\u764c\uff08\u4f8b\u5982TNBC\uff09\u4e2d\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u4fb5\u88ad\u548c\u8f6c\u79fb\u5e76\u51cf\u5c11\u5176\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>IKBKE\u662f\u4e73\u817a\u764c\u4e2d\u7684\u81f4\u764c\u57fa\u56e0\uff0c\u6700\u8fd1\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0IKBKE\u5728\u4e73\u817a\u764c\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u4e2d\u4e5f\u626e\u6f14\u91cd\u8981\u89d2\u8272\u3002\u901a\u8fc7\u5c0f\u5e72\u6270RNA\uff08siRNA\uff09\u6765\u6291\u5236IKBKE\u56e0\u800c\u6210\u4e3a\u4e00\u4e2a\u6f5c\u5728\u7684TNBC\u6cbb\u7597\u65b9\u6848\u3002\u5c3d\u7ba1\u9488\u5bf9\u809d\u810f\u7684siRNA\u6cbb\u7597\u836f\u7269\u6700\u8fd1\u53d6\u5f97\u4e86\u6210\u529f\uff0c\u4f46\u5982\u4f55\u5c06siRNA\u9012\u9001\u81f3\u5b9e\u4f53\u7624\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u6311\u6218\u3002\u5bc6\u82cf\u91cc\u5927\u5b66\u582a\u8428\u65af\u5206\u6821\u7684\u7a0b\u5764\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u62a5\u9053\u4e86\u4e00\u79cd\u6df7\u5408\u7eb3\u7c73\u590d\u5408\u7269\uff0c\u53ef\u5c06IKBKE siRNA\u548c\u5361\u5df4\u4ed6\u8d5b\u5171\u540c\u9012\u9001\u81f3TNBC\u4ee5\u5b9e\u73b0\u6700\u4f73\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002\u8be5\u56e2\u961f\u901a\u8fc7\u4f7f\u7528\u900f\u660e\u8d28\u9178\uff08HA\uff09\u4fee\u9970\u7eb3\u7c73\u590d\u5408\u7269\u7528\u4e8e\u9776\u5411TNBC\u7ec6\u80de\u4e0a\u7684CD44\uff0c\u5e76\u663e\u793a\u51fa\u8f83\u9ad8\u7684\u7ec6\u80de\u6444\u53d6\u548c\u66f4\u597d\u7684\u80bf\u7624\u6e17\u900f\u6548\u679c\u3002\u5728\u5c0f\u9f20\u539f\u4f4dTNBC\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u7eb3\u7c73\u590d\u5408\u7269\u8fd8\u663e\u793a\u51fa\u9ad8\u80bf\u7624\u84c4\u79ef\u6027\u548c\u6297\u80bf\u7624\u6d3b\u6027\u3002\u6b64\u5916\uff0c\u8be5\u7eb3\u7c73\u590d\u5408\u7269\u4e2d\u5305\u88f9\u7684\u5361\u5df4\u4ed6\u8d5b\u80fd\u591f\u8fdb\u4e00\u6b65\u589e\u5f3aIKBKE siRNA\u5bf9\u4e8eTNBC\u7684\u6cbb\u7597\u6548\u679c\u3002\u8be5\u6742\u5408\u7eb3\u7c73\u590d\u5408\u7269\u4e3a\u4f7f\u7528siRNA\u548c\u5316\u5b66\u7597\u6cd5\u7684\u8054\u5408\u7528\u836f\u65b9\u6848\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u9896\u4e14\u901a\u7528\u7684\u5e73\u53f0\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201cCo-delivery of IKBKE siRNA and cabazitaxel by hybrid nanocomplex inhibits invasiveness and growth of triple-negative breast cancer\u201d<\/strong>\u53d1\u8868\u5728Science Advances<\/strong>\u4e0a<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1.IKBKE siRNA<\/strong>\u5728<\/strong>MDA-MB-231<\/strong>\u7ec6\u80de\u4e2d\u7684\u751f\u7269\u5b66\u6d3b\u6027<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09IKBKE siRNA\u5728mRNA\u6c34\u5e73\u4e0a\u7684\u57fa\u56e0\u6c89\u9ed8\u4f5c\u7528<\/p>\n

\uff08B\uff09IKBKE siRNA\u5728\u86cb\u767d\u8d28\u6c34\u5e73\u7684\u57fa\u56e0\u6c89\u9ed8\u6d3b\u6027<\/p>\n

\uff08C-G\uff09IKBKE siRNA\u5bf9MDA-MB-231\u7ec6\u80de\u8fc1\u79fb\uff0c\u4fb5\u88ad\u548c\u589e\u6b96\u7684\u6291\u5236\u4f5c\u7528<\/p>\n

\uff08H\uff09IKBKE siRNA\u5bf9MDA-MB-231\u7ec6\u80de\u51cb\u4ea1\u548c\u574f\u6b7b\u7684\u5f71\u54cd<\/p>\n

\uff08I,J\uff09IKBKE siRNA\u5728\u76ae\u4e0b\u5f02\u79cd\u79fb\u690dTNBC\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u4f53\u5185\u6297\u80bf\u7624\u529f\u6548<\/p>\n

\u56fe<\/strong>2.HA<\/strong>\u4fee\u9970\u7684<\/strong>siRNA<\/strong>\u7eb3\u7c73\u590d\u5408\u7269\u7684\u793a\u610f\u56fe\uff0c\u8868\u5f81\u53ca\u4f53\u5916\u57fa\u56e0\u6c89\u9ed8<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u80c6\u56fa\u9187\u4fee\u9970\u591a\u80bd\uff08CP\uff09\u81ea\u7ec4\u88c5\u6210\u80f6\u675f\u72b6\u7ed3\u6784\uff0c\u7528\u4e8e\u5305\u5c01\u5361\u5df4\u4ed6\u8d5b\uff0c\u5e76\u8fdb\u4e00\u6b65\u4e0eIKBKE siRNA\u7ed3\u5408\uff0c\u5e76\u6577\u4e0a\u80c6\u56fa\u9187\u4fee\u9970HA\uff08CHA\uff09\u4ee5\u5f62\u6210\u6742\u5316siRNA\u7eb3\u7c73\u590d\u5408\u7269<\/p>\n

\uff08B\uff09\u4e0d\u540cN\/P\u6bd4\u503c\u4e0bsiRNA\u7eb3\u7c73\u590d\u5408\u7269\u7684\u51dd\u80f6\u963b\u6ede\u6d4b\u5b9a\u7ed3\u679c<\/p>\n

\uff08C-F\uff09\u4e0d\u540cN\/P\u6bd4\u503c\u4e0bsiRNA\u7eb3\u7c73\u590d\u5408\u7269\u7684Zeta\u7535\u4f4d\uff0c\u7c92\u5f84\u7ed3\u679c\uff0c\u4ee5\u53ca\u5728mRNA\u53ca\u86cb\u767d\u6c34\u5e73\u7684\u57fa\u56e0\u6c89\u9ed8\u6d3b\u6027<\/p>\n

\uff08G-H\uff09\u6577\u8f7d\u4e0d\u540c\u767e\u5206\u6bd4\u7684CHA\u65f6\uff0c siRNA\u7eb3\u7c73\u590d\u5408\u7269\u7684\u51dd\u80f6\u963b\u6ede\u6d4b\u5b9a\u548czeta\u7535\u4f4d\u7ed3\u679c<\/p>\n

\u56fe<\/strong>3.HA<\/strong>\u4fee\u9970\u7684<\/strong>siRNA<\/strong>\u7eb3\u7c73\u590d\u5408\u7269\u7684\u7ec6\u80de\u6444\u53d6<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A-C\uff09\u8f6c\u67d32\u30014\u548c6\u5c0f\u65f6\u540e\uff0c\u7ec6\u80de\u6444\u53d6\u6e38\u79bbsiRNA\uff0cCP\/siRNA\u7eb3\u7c73\u590d\u5408\u7269\u548cCHA\/CP\/siRNA\u7eb3\u7c73\u590d\u5408\u7269\u6d41\u5f0f\u7ec6\u80de\u4eea\u56fe\u50cf\u53ca\u5206\u6790\u7ed3\u679c<\/p>\n

\uff08D-E\uff09siRNA\u7eb3\u7c73\u590d\u5408\u7269\u8f6c\u67d32\u5c0f\u65f6\u548c6\u5c0f\u65f6\u540e\u7ec6\u80de\u5171\u805a\u7126\u56fe\u50cf<\/p>\n

\u56fe<\/strong>4.<\/strong>\u88c5\u8f7d\u5361\u5df4\u4ed6\u8d5b\u7684<\/strong>siRNA<\/strong>\u7eb3\u7c73\u590d\u5408\u7269\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09CP\uff0cCP\/siRNA\u7eb3\u7c73\u590d\u5408\u7269\u548cCHA\/CP\/siRNA\u7eb3\u7c73\u590d\u5408\u7269\u7684\u4e34\u754c\u80f6\u675f\u6d53\u5ea6<\/p>\n

\uff08B-C\uff09CHA\/CP\/siRNA\u548cCHA\/CP\/siRNA\/CTX\u7eb3\u7c73\u590d\u5408\u7269\u7684\u7c92\u5f84\u548cTEM\u56fe\u50cf<\/p>\n

\uff08D\uff09\u7eb3\u7c73\u590d\u5408\u7269\u5728\u86cb\u767d\u8d28\u6c34\u5e73\u7684\u57fa\u56e0\u6c89\u9ed8\u6d3b\u6027<\/p>\n

\uff08E-F\uff09CHA\/CP\/siRNA\/CTX\u7eb3\u7c73\u590d\u5408\u7269\u572850\uff05\u4eba\u8840\u6e05\u548c\u5c0f\u9f20\u8840\u6e05\u4e2d\u7684\u8840\u6e05\u7a33\u5b9a\u6027<\/p>\n

\u56fe<\/strong>5.HA<\/strong>\u4fee\u9970\u7684<\/strong>siRNA<\/strong>\u7eb3\u7c73\u590d\u5408\u7269\u7684<\/strong>3D<\/strong>\u80bf\u7624\u7403\u4f53\u6e17\u900f\u3001\u4fb5\u88ad\u548c\u51cb\u4ea1\u7814\u7a76<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A-F\uff09\u5b75\u80b21\u5c0f\u65f6\u548c2\u5c0f\u65f6\u540e\uff0cCP\/Cy5-siRNA\/Coumarin 6\u548cCHA\/CP\/Cy5-siRNA\/Coumarin 6\u7eb3\u7c73\u590d\u5408\u7269\u57283D\u7c7b\u7403\u4f53\u4e0a\u7684z-stack\u5171\u805a\u7126\u56fe\uff0c\u4ee5\u53caCy5-siRNA\u4ee5\u53caCoumarin 6\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\u91cf\u5316\u5206\u6790\u56fe\u50cf<\/p>\n

\uff08G-H\uff09MDA-MB-231\u7ec6\u80de\u57283D\u7c7b\u7403\u4f53\u4e2d\u4fb5\u88ad\u4f5c\u7528\u56fe\u50cf\u53ca\u91cf\u5316\u5904\u7406\u7ed3\u679c<\/p>\n

\uff08I-J\uff09\u5728\u4e0d\u540c\u7ed9\u836f\u6761\u4ef6\u4e0b\uff0c\u4f7f\u7528\u6d41\u5f0f\u7ec6\u80de\u4eea\u5bf9\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u8fc7\u7a0b\u7814\u7a76\u56fe\u50cf\u53ca\u767e\u5206\u6bd4\u5206\u6790\u7ed3\u679c<\/p>\n

\u56fe<\/strong>6.HA<\/strong>\u4fee\u9970\u7684<\/strong>siRNA<\/strong>\u7eb3\u7c73\u590d\u5408\u7269\u5728\u5c0f\u9f20\u539f\u4f4d<\/strong>TNBC<\/strong>\u80bf\u7624\u6a21\u578b\u4e2d\u7684\u751f\u7269\u5206\u5e03\u548c\u6297\u80bf\u7624\u6d3b\u6027<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u7528Cy5\u6807\u8bb0IKBKE siRNA\u540e\uff0c\u4e0d\u540c\u65f6\u95f4\u95f4\u9694\u7684\u5c0f\u9f20\u6d3b\u4f53\u6210\u50cf\u7ed3\u679c<\/p>\n

\uff08B\uff09\u6ce8\u5c04\u540e48\u5c0f\u65f6\uff0c\u5c0f\u9f20\u4e0d\u540c\u7ec4\u7ec7\u7684\u8367\u5149\u56fe\u50cf\uff08\u809d\u810f\uff0c\u813e\u810f\uff0c\u80bf\u7624\uff0c\u80ba\uff0c\u80be\uff0c\u5fc3\u810f\u548c\u808c\u8089\uff09<\/p>\n

\uff08C\uff09\u6ce8\u5c04\u540e48\u5c0f\u65f6\uff0c\u5c0f\u9f20\u4e0d\u540c\u5668\u5b98\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff08\u5bf9\u6bd4\u5fc3\u810f\uff09<\/p>\n

\uff08D\uff09\u9759\u8109\u6ce8\u5c04\u4e0d\u540c\u5236\u5242\u540e\uff0c\u8bb0\u5f55MDA-MB-231\u539f\u4f4d\u79fb\u690d\u8377\u7624\u5c0f\u9f20\u80bf\u7624\u4f53\u79ef\u751f\u957f\u66f2\u7ebf \uff08\u6bcf\u7ec4n=7\uff09<\/p>\n

\uff08E-F\uff09\u6536\u83b7\u4e0d\u540c\u5236\u5242\u7ed9\u836f\u540e\u80bf\u7624\u7684\u56fe\u50cf\u4ee5\u53ca\u80bf\u7624\u91cd\u91cf\u5206\u6790\u7ed3\u679c<\/p>\n

\uff08G\uff09\u9759\u8109\u6ce8\u5c04\u4e0d\u540c\u5236\u5242\u540e\uff0cIKBKE\u86cb\u767d\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u5206\u6790\u7ed3\u679c<\/p>\n

\uff08H-I\uff09TUNEL\u5206\u6790\u4e0d\u540c\u5236\u5242\u7ed9\u836f\u540e\u80bf\u7624\u6807\u672c\u4e2d\u51cb\u4ea1\u7ec6\u80de\u7684\u8367\u5149\u56fe\u50cf\u4ee5\u53ca\u5b9a\u91cf\u5206\u6790\u7ed3\u679c<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5<\/strong>\uff1aCo-delivery of IKBKE siRNA and cabazitaxel by hybrid nanocomplex inhibits invasiveness and growth of triple-negative breast cancer. Sci. Adv., <\/em>2020<\/strong>, DOI: 10.1126\/sciadv.abb0616<\/p>\n

\u672c\u6587\u7531tt\u4f9b\u7a3f\u3002\u00a0<\/p>\n

\u4f5c\u8005\u56e2\u961f\u4ecb\u7ecd\uff1a<\/p>\n

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\u76f8\u5173\u9886\u57df\u7684\u5176\u4ed6\u8bba\u6587\u8fd8\u6709\uff1a<\/p>\n

    \n
  1. Ashutosh Barve, Akshay Jain, Hao Liu, Zhen Zhao, Kun Cheng. (2020) Enzyme-Responsive Polymeric Micelles of Cabazitaxel for Prostate Cancer Targeted Therapy. Acta Biomaterialia.<\/li>\n
  2. Yuanke Li, Zhen Zhao, Hao Liu, John Peter Fetse, Akshay Jain, Chien-Yu Lin, Kun Cheng. (2019) Development of a Tumor-Responsive Nanopolyplex Targeting Pancreatic Cancer Cells and Stroma. ACS Applied Materials & Interfaces. 11(49):45390-45403<\/li>\n
  3. Hao Liu, Zhen Zhao, Li Zhang, Yuanke Li, Akshay Jain, Ashutosh Barve, Wei Jin, Yanli Liu, John Fetse, Kun Cheng (2019) Discovery of Low-Molecular Weight Anti-PD-L1 Peptides for Cancer Immunotherapy. Journal for ImmunoTherapy of Cancer 7(1):270<\/li>\n
  4. Zhen Zhao, Yuanke Li, Ravi Shukla, Hao Liu, Akshay Jain, Ashutosh Barve, Kun Cheng (2019) Development of a Copolymer Nanocomplex to Deliver VEGF siRNA for Triple Negative Breast Cancer. Theranostics. 9(15):4508-4524<\/li>\n
  5. Zhen Zhao, Yuanke Li, Akshay Jain, Zhijin Chen, Hao Liu, Wei Jin, Kun Cheng (2018) Development of a Peptide-Modified siRNA Nanocomplex for Hepatic Stellate cells. Nanomedicine: Nanotechnology, Biology, and Medicine. 14(1):51-61<\/li>\n<\/ol>\n

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