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Sleiman\u56e2\u961f\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u8054\u5408<\/strong>\u62a5\u9053\u4e86\u5728\u4e09\u805a\u6c30\u80fa\uff08MA\uff09\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0c\u805a\uff08\u80f8\u817a\u5627\u5576\uff0cT\uff09\u4f1a\u81ea\u7f14\u5408\u6210\u53cd\u5e73\u884c\u7684\u53f3\u624b\u53cc\u94fe\u4f53\uff0c\u5176\u4e2d\uff0c\u4e09\u805a\u6c30\u80fa\u662f\u5448\u73b0\u817a\u560c\u5464\u6c22\u952e\u7ed3\u5408\u9762\u7684\u4e00\u4e2a\u4e09\u8054\u7684\u5c0f\u5206\u5b50\u3002\u5229\u7528X\u5c04\u7ebf\u6676\u4f53\u5b66\u5206\u6790\u53d1\u73b0\uff0c\u5728\u590d\u5408\u7269\u4e2d\uff0c\u4e24\u6761\u805a\uff08\u80f8\u817a\u5627\u5576\uff09\u94fe\u7f20\u7ed5\u5728\u4e09\u805a\u6c30\u80fa\u7684\u87ba\u65cb\u67f1\u4e0a\uff0c\u800c\u4e09\u805a\u6c30\u80fa\u7684\u6c22\u952e\u7ed3\u5408\u5728\u5176\u4e09\u4e2a\u9762\u4e0a\u7684\u4e24\u4e2a\u80f8\u817a\u5627\u5576\u6b8b\u57fa\u4e0a\u3002\u7531\u4e8e\u80f8\u817a\u5627\u5576-\u4e09\u805a\u6c30\u80fa-\u80f8\u817a\u5627\u5576\u4e09\u8054\u4f53\u7684\u673a\u68b0\u5f3a\u5ea6\u8d85\u8fc7\u817a\u560c\u5464-\u80f8\u817a\u5627\u5576\u78b1\u57fa\u5bf9\u7684\u673a\u68b0\u5f3a\u5ea6\uff0c\u56e0\u800c\u80fd\u591f\u7075\u654f\u7684\u68c0\u6d4b3 pM\u7684\u4e09\u805a\u6c30\u80fa\u3002\u540c\u65f6\uff0c\u805a\uff08\u80f8\u817a\u5627\u5576\uff09-\u4e09\u805a\u6c30\u80fa\u53cc\u94fe\u4f53\u53ef\u4e0e\u5929\u7136DNA\u78b1\u57fa\u914d\u5bf9\u6b63\u4ea4\uff0c\u5e76\u4e14\u53ef\u4ee5\u8fdb\u884c\u94fe\u7f6e\u6362\uff0c\u800c\u65e0\u9700\u7a81\u51fa\u7aef\u3002\u6b64\u5916\uff0c\u5c06\u5b83\u7ed3\u5408\u5230\u4e8c\u7ef4\uff082D\uff09\u7f51\u683c\u548c\u6742\u5316DNA\u5c0f\u5206\u5b50\u805a\u5408\u7269\u4e2d\uff0c\u7a81\u663e\u4e86\u805a\u80f8\u817a\u5627\u5576-\u4e09\u805a\u6c30\u80fa\u53cc\u94fe\u4f53\u53ef\u4ee5\u4f5c\u4e3aDNA\u7eb3\u7c73\u6280\u672f\u7684\u53e6\u4e00\u79cd\u5de5\u5177\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cA poly(thymine)-melamine duplex for the assembly of DNA nanomaterials\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aNat. Mater.<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n \u56fe\u4e00\u3001MA\u548cT\u4e4b\u95f4\u6f5c\u5728\u7684\u6c22\u952e\u7edc\u5408\u7269<\/strong> \uff08b\uff09\u4e00\u4e2aT3<\/sub>-MA\u6742\u56db\u8054\u4f53\u5bfc\u81f4\u4e00\u4e2a\u805a\uff08T\uff09\u540c\u53cc\u94fe\u4f53\u548c\u540c\u4e09\u8054\u4f53\u3002<\/p>\n \u56fe\u4e8c\u3001\u5929\u7136PAGE\u4e0e\u805a\uff08T\uff09-MA\u76f8\u4e92\u4f5c\u7528\u7684\u5206\u6790<\/strong> \uff08d-e\uff09\u76d1\u6d4b\u7531MA\u4ecb\u5bfcDNA\u53d1\u5939\u7684DNA\u6298\u53e0\uff1a\u572825o<\/sup>C\u30010 mM MA\u548c\u572825o<\/sup>C\u300110 mM MA\u3002<\/p>\n \u56fe\u4e09\u3001T6<\/sub>-MA\u590d\u5408\u7269\u7684\u6676\u4f53\u5b66\u7814\u7a76<\/strong> \uff08b\uff09T6<\/sub>-MA\u6676\u4f53\u7684\u5149\u5b66\u56fe\u50cf\uff1b<\/p>\n \uff08c\uff09T6<\/sub>-MA\u53cc\u94fe\u4f53\u7684\u7ed3\u6784\u6a21\u578b\uff1b<\/p>\n \uff08d\uff09MA\u4ecb\u5bfc\u7684T-T bp\u7684\u7ec6\u8282\uff1b<\/p>\n \uff08e\uff09\u805a\uff08T\uff09-MA\u53cc\u94fe\u4f53\u9002\u5408\u6676\u4f53\u4e2d\u5f7c\u6b64\u7684\u4e3b\u8981\u51f9\u69fd\u7684\u7acb\u4f53\u56fe\u50cf\uff1b<\/p>\n \uff08f-g\uff09\u6cbf\u4e09\u6298\u548c\u56db\u6298\u87ba\u65cb\u8f74\u7ebf\u89c2\u5bdfT6<\/sub>-MA\u6676\u4f53\u4e2d\u7684\u6676\u4f53\u5806\u79ef\uff0cMA\u4e3a\u84dd\u8272\u3002<\/p>\n \u56fe\u56db\u3001\u805a\uff08T\uff09-MA\u53cc\u94fe\u4f53\u7684\u673a\u68b0\u6027\u80fd<\/strong> \uff08b\uff09\u5728\u53d1\u5939\u4e2d\u542b\u670920\u4e2aA-T bp\u7684\u5bf9\u7167DNA\u6784\u5efa\u4f53\u7684\u793a\u610f\u56fe\uff1b<\/p>\n \uff08c\uff09\u6709\u65e0MA\uff08100 \u00b5M\uff09\u768420 T-T\u548c20 A-T DNA\u7684\u4ee3\u8868\u6027F-X\u66f2\u7ebf\uff1b<\/p>\n \uff08d\uff0920 T-T\u7ed3\u6784\u5728100 \u00b5M MA\u5b58\u5728\u4e0b\u548c20 A-T\u7ed3\u6784\u5728MA\u4e0d\u5b58\u5728\u4e0b\u7684RF\u548c\u2206L\u76f4\u65b9\u56fe\uff1b<\/p>\n \uff08e\uff09\u4e0d\u4f7f\u7528MA\u6216\u4f7f\u7528MA\u7684\u4e0d\u540c\u6784\u9020\u4e2d\u6298\u53e0\u7269\u79cd\u7684\u767e\u5206\u6bd4\u3002<\/p>\n \u56fe\u4e94\u3001\u5229\u7528\u805a\uff08T\uff09\u6a21\u677f\u5bf9MA\u8fdb\u884c\u673a\u68b0\u5316\u5b66\u68c0\u6d4b<\/strong> \uff08b-c\uff09\u572810 mM Tris\u548c100 mM KCl\uff08pH=7.4\uff09\u7f13\u51b2\u6db2\u4e2d\uff0cMA\u572810 pM\u548c1 pM\u4e0b\u7684\u5c55\u5f00F-X\u66f2\u7ebf\u3002<\/p>\n \u56fe\u516d\u3001\u5e94\u7528\u805a\uff08T\uff09-MA\u7f16\u7a0bDNA\u7eb3\u7c73\u7ed3\u6784\u7684\u81ea\u7ec4\u88c5<\/strong> \uff08d-f\uff09DNA 3PS\u74f7\u7816\u7ec4\u88c5\u6210\u516d\u8fb9\u5f622D\u9635\u5217\uff1b<\/p>\n \uff08g-i\uff09DNA 4PS\u74f7\u7816\u7ec4\u88c5\u6210\u56db\u8fb9\u5f622D\u9635\u5217\u3002<\/p>\n \u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n \u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u7814\u7a76\u53d1\u73b0MA\u53ef\u4ee5\u4ecb\u5bfc\u805a\uff08T\uff09\u5728\u6c34\u4e2d\u5f62\u6210\u53cd\u5e73\u884c\u7684\u805a\uff08T\uff09-MA\u53cc\u94fe\u4f53\u3002\u8fd9\u79cd\u7ed3\u6784\u5728\u5806\u53e0\u7684T-MA-T\u5bf9\u89e3\u538b\u7f29\u8fc7\u7a0b\u4e2d\u5177\u6709\u5f88\u5f3a\u7684\u673a\u68b0\u7a33\u5b9a\u6027\u548c\u53ef\u8c03\u7684\u70ed\u7a33\u5b9a\u6027\uff0c\u4f7f\u5f97\u5176\u53ef\u4ee5\u8c03\u8282DNA\u7eb3\u7c73\u7ed3\u6784\u7684\u81ea\u7ec4\u88c5\u3002\u867d\u7136\u4e4b\u524d\u5df2\u89c2\u5bdf\u5230\u805a\uff08T\uff09\u4e0e\u5e26\u6b63\u7535\u8377\u7684\u805a\uff08\u4e09\u805a\u6c30\u80fa\uff09\u76f8\u4e92\u4f5c\u7528\uff0c\u4f46\u662f\u6b64\u7ec4\u88c5\u4f9d\u8d56\u4e8e\u591a\u4ef7\u6001\u548c\u9759\u7535\u5438\u5f15\u3002\u5728\u672c\u6587\u4e2d\uff0c\u5355\u4e2a\u7684MA\u5206\u5b50\u4ee3\u66ff\u805a\uff08\u4e09\u805a\u6c30\u80fa\uff09\uff0c\u5e76\u514b\u670d\u4e86\u6dfb\u52a0\u7684\u71b5\u5792\uff0c\u4ece\u800c\u751f\u6210\u4e86\u805a\uff08T\uff09-MA\u53cc\u94fe\u4f53\u3002\u6b64\u5916\uff0c\u5229\u7528\u5c0f\u5206\u5b50\u8c03\u8282DNA\u7279\u6027\u7684\u80fd\u529b\u6269\u5c55\u4e86\u5bf9DNA\u5316\u5b66\u7684\u8ba4\u8bc6\uff0c\u8d85\u8d8a\u4e86Watson-Crick\u78b1\u57fa\u914d\u5bf9\uff0c\u5e76\u63d0\u4f9b\u4e86\u4e00\u79cd\u66ff\u4ee3\u7684\u5ec9\u4ef7\u65b9\u6cd5\u6765\u751f\u6210\u57fa\u4e8eDNA\u7684\u4f53\u7cfb\u7ed3\u6784\u3002<\/p>\n
\n \uff08a\uff09\u4e00\u4e2aT2<\/sub>-MA\u6742\u4e09\u8054\u4f53\u5bfc\u81f4\u4e00\u4e2a\u805a\uff08T\uff09\u540c\u53cc\u94fe\u4f53\u548c\u540c\u4e09\u8054\u4f53\uff1b<\/p>\n
\n \uff08a-c\uff09\u6539\u53d8MA\u7684\u6d53\u5ea6\u6216\u6e29\u5ea6\u7684\u5f71\u54cd\uff1a\u572825o<\/sup>C\u30010 mM MA\u65f6\uff0c\u572825o<\/sup>C\u300110 mM MA\u65f6\u548c\u572837o<\/sup>C\u300110 mM MA\u65f6\uff1b<\/p>\n
\n \uff08a\uff09T6<\/sub>-MA\u53cc\u5de5\u793a\u610f\u56fe\uff1b<\/p>\n
\n \uff08a\uff09\u5305\u542b20\u4e2aT-T\u4e0d\u914d\u5bf9\u7684T-MA-T\u5f62\u6210\u7684DNA\u6784\u9020\u793a\u610f\u56fe\uff1b<\/p>\n
\n \uff08a\uff09\u7531RCA\u5236\u5907\u7684\u805a\uff08T\uff09\u68c0\u6d4b\u51fa\u6784\u5efa\u4f53\u7684\u793a\u610f\u56fe\uff1b<\/p>\n
\n \uff08a-c\uff09DNA DX\u7ec4\u88c5\u6210\u4e00\u7ef4\uff081D\uff09\u94fe\uff1b<\/p>\n