{"id":205510,"date":"2020-07-19T06:59:36","date_gmt":"2020-07-18T22:59:36","guid":{"rendered":"\/\/m.iemloyee.com\/?p=205510"},"modified":"2020-07-18T19:59:50","modified_gmt":"2020-07-18T11:59:50","slug":"%e5%8c%97%e5%8c%96%e5%b7%a5%e8%bf%87%e7%a8%8b%e5%b7%a5%e7%a8%8b%e7%a0%94%e7%a9%b6%e6%89%80-am%ef%bc%9a%e9%a6%96%e6%ac%a1%e5%88%a9%e7%94%a8%e5%85%8d%e7%96%ab%e8%b0%83%e8%8a%82%e5%a2%9e%e5%bc%ba","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=205510","title":{"rendered":"\u5317\u5316\u5de5&\u8fc7\u7a0b\u5de5\u7a0b\u7814\u7a76\u6240 AM\uff1a\u9996\u6b21\u5229\u7528\u514d\u75ab\u8c03\u8282\u589e\u5f3a\u57fa\u4e8e\u7eb3\u7c73\u9176\u7684\u50ac\u5316\u6cbb\u7597\u80bf\u7624"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u7eb3\u7c73\u9176<\/strong>\u662f\u4e00\u7c7b\u65e2\u6709\u7eb3\u7c73\u6750\u6599\u7684\u72ec\u7279\u6027\u80fd\uff0c\u53c8\u6709\u50ac\u5316\u529f\u80fd\u7684\u6a21\u62df\u9176\u3002\u5176\u5177\u6709\u50ac\u5316\u6548\u7387\u9ad8\u3001\u7a33\u5b9a\u3001\u7ecf\u6d4e\u548c\u6613\u89c4\u6a21\u5316\u5236\u5907\u7b49\u4f18\u52bf\uff0c\u5728\u533b\u5b66\u3001\u5316\u5de5\u3001\u98df\u54c1\u3001\u519c\u4e1a\u548c\u73af\u5883\u7b49\u9886\u57df\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\u3002\u5f53\u524d\uff0c\u7814\u7a76\u4eba\u5458\u6b63\u5728\u5927\u529b\u5f00\u53d1\u57fa\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u54cd\u5e94\u6027\u7eb3\u7c73\u9176\u7684\u80bf\u7624\u50ac\u5316\u7597\u6cd5\u3002\u56e0\u4e3aTME\u5177\u6709\u8f7b\u5ea6\u7684\u9178\u6027\u3001\u4f4e\u6c27\u5fae\u73af\u5883\u4ee5\u53ca\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u548c\u8fc7\u6c27\u5316\u6c22\uff08H2<\/sub>O2<\/sub>\uff09\u8fc7\u8868\u8fbe\u7684\u7279\u5f02\u6027\uff0c\u4f7f\u5f97\u7eb3\u7c73\u9176\u5bf9\u80bf\u7624\u5177\u6709\u9ad8\u7279\u5f02\u6027\u800c\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u4f4e\u6bd2\u3002\u7136\u800c\uff0c\u80bf\u7624\u533a\u57df\u5185\u6e90\u6027H2<\/sub>O2<\/sub>\u6d53\u5ea6\uff0850-100\u00d710-6<\/sup> M\uff09\u89e6\u53d1\u7eb3\u7c73\u9176\u7684\u6d3b\u6027\u4f7f\u5f97\u4ea7\u751f\u6d3b\u6027\u6c27\uff08ROS\uff09\u7684\u6c34\u5e73\u8f83\u4f4e\uff0c\u5bfc\u81f4\u671f\u50ac\u5316\u6027\u80fd\u8f83\u5dee\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u4e00\u79cd\u66f4\u6709\u6548\u7684TME\u54cd\u5e94\u6cbb\u7597\u7b56\u7565\uff0c\u4ee5\u589e\u5f3a\u57fa\u4e8e\u7eb3\u7c73\u9176\u7684\u80bf\u7624\u50ac\u5316\u6cbb\u7597\u6548\u679c\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u5728TME\u4e2d\uff0c\u4e0e\u80bf\u7624\u76f8\u5173\u7684\u5de8\u566c\u7ec6\u80de\uff08TAMs\uff09\u662f\u6570\u91cf\u6700\u591a\u7684\u975e\u80bf\u7624\u6027\u514d\u75ab\u7ec6\u80de\u4e4b\u4e00\uff0c\u4e0e\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg<\/sub>\uff09\u4e00\u8d77\u5728\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb\u4e2d\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\u3002\u901a\u5e38TAMs\u8868\u8fbeM2\u578b\uff0c\u800cM2\u578b\u5177\u6709\u514d\u75ab\u6291\u5236\u548c\u4fc3\u8fdb\u80bf\u7624\u529f\u80fd\u3002\u4f46\u662f\uff0c\u5bf9M1\u578b\u7684\u6781\u5316\u53ef\u4ee5\u6539\u5584\u514d\u75ab\u6291\u5236\uff0c\u5e76\u589e\u52a0\u80bf\u7624\u5185H2<\/sub>O2<\/sub>\u7684\u6d53\u5ea6\u4ee5\u6f5c\u5728\u5730\u589e\u5f3a\u7eb3\u7c73\u9176\u7684\u50ac\u5316\u6d3b\u6027\u3002\u56e0\u6b64\uff0c\u5c06\u57fa\u4e8e\u7eb3\u7c73\u9176\u7684\u80bf\u7624\u50ac\u5316\u7597\u6cd5\u4e0eTME\u514d\u75ab\u8c03\u8282\u76f8\u7ed3\u5408\u975e\u5e38\u6709\u5e0c\u671b\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5317\u4eac\u5316\u5de5\u5927\u5b66\u7684\u5218\u60e0\u7389\u6559\u6388\u548c\u4e2d\u79d1\u9662\u8fc7\u7a0b\u5de5\u7a0b\u7814\u7a76\u6240\u7684\u9b4f\u709c\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba<\/strong>\u9996\u6b21\u62a5\u9053\u4e86\u4e00\u79cd\u5229\u7528\u514d\u75ab\u8c03\u8282\u589e\u5f3a\u57fa\u4e8e\u7eb3\u7c73\u9176\u7684\u80bf\u7624\u50ac\u5316\u6cbb\u7597\u7684\u65b9\u6cd5\u6cd5\uff0c\u4ee5\u5b9e\u73b0\u7eb3\u7c73\u9176\u4e0eTME\u8c03\u63a7\u4e4b\u95f4\u7684\u534f\u540c\u4f5c\u7528\u3002\u4f5c\u8005\u9996\u5148\u5236\u5907\u4e86H2<\/sub>O2<\/sub>\u54cd\u5e94\u6027\u7684\u7845\u9178\u9530\u94c1\u7eb3\u7c73\u9897\u7c92\uff08IMSN\uff09\u7eb3\u7c73\u9176\uff0c\u968f\u540e\u5c06TGF-\u03b2\u6291\u5236\u5242\uff08TI\uff09\u52a0\u8f7d\u5230\u88ab\u805a\u4e59\u4e8c\u9187\u5316\u7684IMSN\u4e2d\u5f62\u6210IMSN-PEG-TI\uff0c\u4ece\u800c\u5b9e\u73b0\u534f\u540c\u6cbb\u7597\u3002\u8be5\u7b56\u7565\u5177\u6709\u4ee5\u4e0b\u7279\u5f81\uff1a\uff081\uff09IMSN\u8868\u73b0\u51fa\u7c7b\u8fc7\u6c27\u5316\u7269\u9176\u7684\u6d3b\u6027\uff0c\u5c06H2<\/sub>O2<\/sub>\u5206\u89e3\u4e3a\u7f9f\u57fa\u81ea\u7531\u57fa\uff08\u2022OH\uff09\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\uff0c\u540c\u65f6\u5177\u6709\u7c7b\u8fc7\u6c27\u5316\u6c22\u9176\u6d3b\u6027\uff0c\u5c06H2<\/sub>O2<\/sub>\u5206\u89e3\u4e3aO2<\/sub>\uff0c\u4ee5\u514b\u670d\u80bf\u7624\u7684\u7f3a\u6c27\u5fae\u73af\u5883\uff1b\uff082\uff09\u901a\u8fc7\u91cd\u65b0\u7f16\u7a0b\u7684TAMs\u589e\u52a0M1\u5de8\u566c\u7ec6\u80de\u7684\u6570\u91cf\u4ee5\u4ea7\u751f\u66f4\u591a\u7684H2O2\uff0c\u8fdb\u800c\u589e\u5f3aIMSN\u7684\u50ac\u5316\u6027\u80fd<\/strong>\u3002\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0cIMSN\u7eb3\u7c73\u9176\u5728\u9178\u6027TME\u4e0b\u786e\u5b9e\u5177\u6709\u7c7b\u8fc7\u6c27\u5316\u7269\u9176\u548c\u7c7b\u8fc7\u6c27\u5316\u6c22\u9176\u6d3b\u6027\uff0c\u53ef\u4ee5\u5c06H2<\/sub>O2<\/sub>\u5206\u89e3\u4e3a\u7f9f\u57fa\uff08\u2022OH\uff09\u548c\u6c27\uff08O2<\/sub>\uff09\u3002\u540c\u65f6\uff0c\u8fd8\u8bc1\u660eIMSN\u548cTI\u5747\u53ef\u8c03\u8282\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\uff0c\u5bfc\u81f4\u5de8\u566c\u7ec6\u80de\u4eceM2\u6781\u5316\u5230M1\uff0c\u4ee5\u4ea7\u751f\u66f4\u591a\u7684H2<\/sub>O2<\/sub>\uff0c\u4ece\u800c\u4fc3\u8fdbIMSN\u7eb3\u7c73\u9176\u7684\u50ac\u5316\u6d3b\u6027\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u4f53\u5916\u591a\u7ec6\u80de\u80bf\u7624\u7403\u4f53\uff08MCTS\uff09\u548c\u4f53\u5185CT26\u8377\u7624\u5c0f\u9f20\u6a21\u578b\u5b9e\u9a8c\u8bc1\u660e\uff0cIMSN-PEG-TI\u786e\u5b9e\u5177\u6709\u9ad8\u6548\u7684\u6297\u80bf\u7624\u6548\u679c\uff0c\u5176\u4e2d\u5728CT26\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u5c0f\u9f20\u6a21\u578b\u4e2d\u4ee587.5\uff05\u7684\u80bf\u7624\u6291\u5236\u7387\u5b9e\u73b0\u4e86\u9ad8\u80bf\u7624\u6cbb\u7597\u6548\u679c\u3002\u603b\u4e4b\uff0c\u5229\u7528\u514d\u75ab\u8c03\u8282\u589e\u5f3a\u57fa\u4e8e\u7eb3\u7c73\u9176\u7684\u80bf\u7624\u6cbb\u7597\u7b56\u7565\u662f\u4e00\u79cd\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u6709\u524d\u9014\u7684\u7b56\u7565\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cImmunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Mater.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001IMSN-PEG-TI\u7684\u5408\u6210\u548c\u80bf\u7624\u6cbb\u7597\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe\u4e8c\u3001IMSN\u7eb3\u7c73\u9176\u7684\u7ed3\u6784\u548c\u7ec4\u6210\u8868\u5f81<\/strong>
\n \"\"\uff08a-b\uff09mSiO2<\/sub>\u548cIMSN\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09IMSN\u7684SEM\u56fe\u50cf\uff1b<\/p>\n

\uff08d\uff09IMSN\u7684STEM\u56fe\u50cf\u548c\u76f8\u5e94\u7684\u5143\u7d20\u6620\u5c04\uff1b<\/p>\n

\uff08e\uff09\u901a\u8fc7DLS\u6d4b\u91cf\u7684IMSN\u7684\u5927\u5c0f\u5206\u5e03\uff1b<\/p>\n

\uff08f-g\uff09IMSN\u7684\u9ad8\u5206\u8fa8\u7387Fe 2p\u548cMn 2p XPS\u5149\u8c31\u3002<\/p>\n

\u56fe\u4e09\u3001IMSN\u7eb3\u7c73\u9176\u7684\u7c7b\u9176\u6d3b\u6027\u8868\u5f81<\/strong>
\n \"\"\uff08a\uff09IMSN\u7684\u7c7b\u8fc7\u6c27\u5316\u7269\u9176\u6d3b\u6027\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09\u5728\u4e0d\u540cpH\u7684PBS\u7f13\u51b2\u6db2\u4e2d\u6dfb\u52a0IMSN\u548cH2<\/sub>O2<\/sub>\u540e\uff0c\u5c06MB\uff08A\/A0<\/sub>\uff09\u7684\u5438\u5149\u5ea6\u6807\u51c6\u5316\uff1b<\/p>\n

\uff08c\uff09\u4e0d\u540c\u7ec4\u4e2doxTMB\u7684\u7d2b\u5916\u53ef\u89c1\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

\uff08d\uff09\u52a0\u5165IMSN\u548c\u4e0d\u540c\u6469\u5c14\u6d53\u5ea6H2O2\u540e\uff0coxTMB\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u5438\u6536\uff1b<\/p>\n

\uff08e-f\uff09\u7a33\u6001\u52a8\u529b\u5b66\u5206\u6790\uff0c\u4ee5\u53caIMSN\u7684Lineweaver-Burk\u56fe\uff1b<\/p>\n

\uff08g\uff09IMSN\u7684\u7c7b\u8fc7\u6c27\u5316\u6c22\u9176\u6d3b\u6027\u7684\u793a\u610f\u56fe\u3002<\/p>\n

\uff08h\uff09\u5728\u4e0d\u540cpH\u7684PBS\u7f13\u51b2\u6db2\u4e2d\u6dfb\u52a0IMSN\u548cH2<\/sub>O2<\/sub>\u540e\u751f\u6210\u7684O2<\/sub>\uff1b<\/p>\n

\uff08i\uff09\u52a0\u5165IMSN\u548c\u4e0d\u540c\u6469\u5c14\u6d53\u5ea6\u7684H2<\/sub>O2<\/sub>\u540e\u751f\u6210\u7684O2<\/sub>\u3002<\/p>\n

\u56fe\u56db\u3001\u5728\u6eb6\u6db2\u548c\u7ec6\u80de\u4e2d\u6d4b\u8bd5IMSN-PEG-TI<\/strong>
\n \"\"\uff08a-c\uff09\u9530\u79bb\u5b50\u3001\u94c1\u79bb\u5b50\u548cTI\u91ca\u653e\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u4e0e\u4e0d\u540cpH\u7684\u7f13\u51b2\u6db2\u5171\u5b75\u80b2\u540eIMSN-PEG-TI\u7684\u91ca\u653e\uff1b<\/p>\n

\uff08d-e\uff09IMSN-PEG-TI\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684T1\u548cT2\u52a0\u6743MR\u56fe\u50cf\uff1b<\/p>\n

\uff08f\uff09\u7528\u4e0d\u540c\u6d53\u5ea6\u7684TI\u3001IMSN-PEG\u548cIMSN-PEG-TI\u5904\u7406\u540e\uff0cHUVEC\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08g-h\uff09\u5bf9\u7167\u7ec4\u3001TI\u3001IMSN-PEG\u548cIMSN-PEG-TI\u5404\u4e2a\u7ec4\u5728\u4e0d\u540c\u5929\u6570\u7684MCTS\u7684\u7167\u7247\u548c\u4f53\u79ef\uff1b<\/p>\n

\uff08i\uff09\u4e0d\u540c\u7ec4\u7684MCTS\u4e2d\u751f\u6210\u7684\u8fc7\u6c27\u5316\u6c22\uff1b<\/p>\n

\uff08j\uff09MCTS\u4e2d\u5de8\u566c\u7ec6\u80de\u5206\u5e03\u7684\u514d\u75ab\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08k\uff09MCTS\u4e2dHIF-1\u03b1\u7684\u514d\u75ab\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08l\uff09MCTS\u4e2dGPX4\u8868\u8fbe\u7684\u514d\u75ab\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e94\u3001IMSN-PEG-TI\u5bf9CT26\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7269\u7684\u4f53\u5185\u514d\u75ab\u8c03\u8282\u589e\u5f3a\u57fa\u4e8e\u7eb3\u7c73\u9176\u7684\u80bf\u7624\u6cbb\u7597<\/strong>
\n \"\"\uff08a\uff09CT26\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7269\u5efa\u7acb\u548c\u6cbb\u7597\u7ed3\u679c\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b-c\uff09\u572815\u5929\u4e0d\u540c\u6cbb\u7597\u540e\uff0c\u643a\u5e26CT26\u7684\u8377\u7624\u5c0f\u9f20\u7684\u4f53\u91cd\u53d8\u5316\u548c\u80bf\u7624\u4f53\u79ef\uff1b<\/p>\n

\uff08d\uff09\u4e0d\u540c\u6cbb\u7597\u540e\u643a\u5e26CT26\u80bf\u7624\u7684\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08e\uff09\u5404\u79cd\u6cbb\u7597\u540e\u80bf\u7624\u5207\u7247\u7684H\uff06E\u67d3\u8272\u3002<\/p>\n

\u56fe\u516d\u3001\u4f53\u5185IMSN-PEG-TI\u8bf1\u5bfc\u80bf\u7624\u5fae\u73af\u5883\u53d8\u5316<\/strong>
\n \"\"\uff08a\uff09\u80bf\u7624\u7ec4\u7ec7\u4e2dM1\u548cM2\u5de8\u566c\u7ec6\u80de\u7684\u514d\u75ab\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\uff08b-d\uff09\u4e0d\u540c\u7ec4\u7684M1\u81f3M2\u5de8\u566c\u7ec6\u80de\u3001CD4+<\/sup> T\u81f3Treg<\/sub>\u7ec6\u80de\u548cCD8+<\/sup> T\u81f3Treg<\/sub>\u7ec6\u80de\uff1b<\/p>\n

\uff08e\uff09\u80bf\u7624\u7ec4\u7ec7\u4e2dHIF-1\u03b1\u7684\u514d\u75ab\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08f\uff09\u80bf\u7624\u7ec4\u7ec7\u4e2dGPX4\u8868\u8fbe\u7684\u514d\u75ab\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aImmunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy<\/a><\/strong>\uff08Adv. Mater.<\/em>, 2020<\/strong>, DOI: 10.1002\/adma.202003563\uff09<\/p>\n

\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n

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