{"id":204824,"date":"2020-07-10T06:39:24","date_gmt":"2020-07-09T22:39:24","guid":{"rendered":"\/\/m.iemloyee.com\/?p=204824"},"modified":"2020-07-09T20:39:45","modified_gmt":"2020-07-09T12:39:45","slug":"%e9%95%bf%e6%98%a5%e5%ba%94%e5%8c%96%e6%89%80-chem-%e5%88%a9%e7%94%a8%e4%b8%ad%e6%80%a7%e7%b2%92%e7%bb%86%e8%83%9e%e8%86%9c%e5%ae%9a%e5%90%91%e7%94%9f%e7%89%a9%e6%ad%a3%e4%ba%a4%e5%90%88%e6%88%90","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=204824","title":{"rendered":"\u957f\u6625\u5e94\u5316\u6240 Chem: \u5229\u7528\u4e2d\u6027\u7c92\u7ec6\u80de\u819c\u5b9a\u5411\u751f\u7269\u6b63\u4ea4\u5408\u6210\u9776\u5411\u708e\u75c7\u7684\u624b\u6027\u836f\u7269"},"content":{"rendered":"

\u3010\u6587\u7ae0\u4eae\u70b9\u3011<\/strong><\/p>\n

1\u3001\u624b\u6027\u7684MSN-Pd\u50ac\u5316\u5242\u7528\u4e8e\u4f53\u5185ATH\u7684\u751f\u7269\u6b63\u4ea4\u53cd\u5e94\u3002<\/p>\n

2\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u819c\u4f7f\u5f97\u8be5\u7eb3\u7c73\u50ac\u5316\u5242\u5177\u6709\u9776\u5411\u708e\u75c7\u7684\u80fd\u529b\u3002<\/p>\n

3\u3001\u5229\u7528\u624b\u6027\u6a21\u578b\u836f\u7269-\u5e03\u6d1b\u82ac\uff0c\u901a\u8fc7\u9776\u5411\u6027ATH\u5408\u6210\u6765\u51cf\u8f7b\u708e\u75c7\u3002<\/p>\n

\u3010\u80cc\u666f\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u836f\u7269\u7684\u5168\u8eab\u6027\u7ed9\u836f\u7ecf\u5e38\u53d7\u5230\u9776\u6807\u7684\u9009\u62e9\u6027\u6709\u9650\u548c\u6f5c\u5728\u7684\u8131\u9776\u5bfc\u81f4\u6bd2\u6027\u7684\u56f0\u6270\u3002\u56e0\u6b64\uff0c\u836f\u7269\u7684\u968f\u673a\u5206\u5e03\u3001\u5feb\u901f\u5931\u6d3b\u3001\u4e0d\u826f\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u8fc7\u65e9\u7684\u6e05\u9664\u7b49\u90fd\u4f1a\u964d\u4f4e\u6cbb\u7597\u6548\u679c\u3002\u76ee\u524d\uff0c\u5c06\u60f0\u6027\u524d\u836f\u5728\u6240\u9700\u90e8\u4f4d\u539f\u4f4d\u8f6c\u5316\u4e3a\u751f\u7269\u6d3b\u6027\u7269\u8d28\u662f\u4e00\u79cd\u589e\u5f3a\u6cbb\u7597\u6548\u679c\u548c\u51cf\u8f7b\u4e0d\u826f\u53cd\u5e94\u7684\u6709\u6548\u65b9\u6cd5\u3002\u5982\u4eca\uff0c\u751f\u7269\u6b63\u4ea4\u5316\u5b66\u662f\u4e00\u79cd\u5f88\u6709\u524d\u666f\u7684\u524d\u836f\u6d3b\u5316\u7b56\u7565\uff0c\u5e76\u4e14\u5df2\u8bc1\u660e\u51e0\u79cd\u7c7b\u578b\u7684\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u53cd\u5e94\u5728\u590d\u6742\u751f\u7269\u73af\u5883\u4e2d\u662f\u53ef\u884c\u548c\u6709\u6548\u7684\u3002\u5176\u4e2d\uff0c\u901a\u8fc7\u78c1\u6027\u9776\u5411\u3001EPR\u6548\u5e94\u3001\u7cbe\u786e\u6ce8\u5c04\u7b49\u65b9\u6cd5\uff0c\u5728\u7279\u5b9a\u7ec6\u80de\u5668\u3001\u7ec6\u80de\u548c\u5668\u5b98\u4e2d\u5b9e\u73b0\u4e86\u524d\u836f\u6d3b\u5316\u7684\u9776\u5411\u751f\u7269\u6b63\u4ea4\u50ac\u5316\u3002\u4f17\u6240\u5468\u77e5\uff0c\u624b\u6027\u662f\u751f\u547d\u7684\u57fa\u672c\u7279\u5f81\u3002\u624b\u6027\u836f\u7269\u7684\u5bf9\u6620\u4f53\u4f5c\u7528\u5f71\u54cd\u6240\u6709\u76f8\u5173\u7684\u836f\u7406\u548c\u6bd2\u7406\u5b66\u8fc7\u7a0b\uff08\u9176\u7ed3\u5408\u3001\u4ee3\u8c22\u7b49\uff09\u3002\u56e0\u6b64\uff0c\u540c\u4e00\u836f\u7269\u7684\u4e24\u79cd\u5bf9\u6620\u5f02\u6784\u4f53\u5728\u53d1\u75c5\u673a\u7406\u3001\u6cbb\u7597\u548c\u526f\u4f5c\u7528\u65b9\u9762\u53ef\u80fd\u6709\u6240\u4e0d\u540c\u3002\u7136\u800c\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u51e0\u4e4e\u6ca1\u6709\u62a5\u9053\u901a\u8fc7\u751f\u7269\u6b63\u4ea4\u53cd\u5e94\u5728\u751f\u7269\u4f53\u5185\u76f4\u63a5\u5408\u6210\u624b\u6027\u7684\u836f\u7269\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u57fa\u4e8e\u6b64\uff0c\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u7528\u5316\u5b66\u7814\u7a76\u6240\u7684\u66f2\u6653\u521a\u7814\u7a76\u5458\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba<\/strong>\u62a5\u9053\u4e86\u4ed6\u4eec\u5229\u7528\u7532\u9178\u94a0\u4f5c\u4e3a\u751f\u7269\u76f8\u5bb9\u6027\u7684\u8fd8\u539f\u5242\uff0c\u6784\u5efa\u4e86\u7528\u4e8e\u4e0d\u5bf9\u79f0\u8f6c\u79fb\u6c22\u5316\uff08ATH\uff09\u53cd\u5e94\u7684\u624b\u6027\u6539\u6027Pd\u50ac\u5316\u5242\uff08MSN-Pd\uff09\u3002\u901a\u8fc7\u7ed3\u5408ATH\u53cd\u5e94\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u819c\u7684\u8d8b\u5316\u6027\uff0c\u5bf9\u624b\u6027Pd\u50ac\u5316\u5242\u8fdb\u884c\u6539\u826f\u5f62\u6210\u4e86\u7528\u4e2d\u6027\u7ec6\u80de\u819c\u5305\u88f9\u7684MSN-Pd\/CD@Neu\u50ac\u5316\u5242\uff0c\u5229\u7528\u8be5\u50ac\u5316\u5242\u5b9e\u73b0\u4e86\u6d3b\u7ec6\u80de\u4e2d\u708e\u75c7\u90e8\u4f4d\u539f\u4f4d\u9009\u62e9\u6027\u5408\u6210\u624b\u6027\u836f\u7269\u3002\u4f5c\u4e3a\u6982\u5ff5\u7684\u9a8c\u8bc1\uff0c\u4f5c\u8005\u901a\u8fc7\u9776\u5411ATH\u53cd\u5e94\u539f\u4f4d\u5408\u6210\u4e86\u624b\u6027\u6a21\u578b\u836f\u7269-\u5e03\u6d1b\u82ac\uff0c\u4ee5\u51cf\u8f7b\u4f5c\u4e3a\u4f53\u5185\u6a21\u578b\u7684\u5c0f\u9f20\u811a\u722a\u4e2d\u7684\u708e\u75c7\u53cd\u5e94\u3002\u4e0e\u5bf9\u7167\u76f8\u6bd4\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u819c\u5305\u88f9\u7684\u624b\u6027Pd\u50ac\u5316\u5242\u5728\u6297\u708e\u4f5c\u7528\u4e2d\u540c\u65f6\u5177\u6709\u9776\u5411\u708e\u75c7\u7684\u80fd\u529b\u548c\u5bf9\u6620\u9009\u62e9\u6027\u3002\u603b\u4e4b\uff0c\u8be5\u7814\u7a76\u53ef\u4ee5\u4e3a\u9776\u5411\u6027\u524d\u836f\u6d3b\u5316\u4e2d\u7684\u751f\u7269\u6b63\u4ea4\u50ac\u5316\u63d0\u4f9b\u65b0\u601d\u8def\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cNeutrophil-Membrane-Directed Bioorthogonal Synthesis of Inflammation-Targeting Chiral Drugs\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aChem<\/strong>\u4e0a\u3002<\/p>\n

\"\"
\n \u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001MSN-Pd\/CD@Neu\u7684\u5236\u5907\u53ca\u7ec6\u80de\u5185\u50ac\u5316\u7684\u793a\u610f\u56fe<\/strong>
\n \"\"\uff08A\uff09\u624b\u6027\u50ac\u5316\u5242MSN-Pd\/CD@Neu\u7684\u5236\u5907\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09\u5728\u6d3b\u6027\u751f\u7269\u4f53\u4e2d\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u819c\u4e3a\u5bfc\u5411\u7684ATH\u7528\u4e8e\u624b\u6027IBU\u7684\u539f\u4f4d\u5408\u6210\u4ee5\u51cf\u8f7b\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n

\u56fe\u4e8c\u3001MSN-Pd\/CD@Neu\u7684\u8868\u5f81<\/strong>
\n \"\"\uff08A-C\uff09MSN\u3001MSN-Pd\u548cMSN-Pd\/CD@Neu\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08D\uff09MSN-Pd\/CD@Neu\u7684\u6697\u573aTEM\u56fe\u4ee5\u53caSi\u3001Pd\u548cP\u7684\u5143\u7d20\u6620\u5c04\uff1b<\/p>\n

\uff08E\uff09MSN-Pd\u3001MSN-Pd\/CD\u548cMSN-Pd\/CD@Neu\u7684\u7c92\u5f84\u5c3a\u5bf8 \uff1b<\/p>\n

\uff08F\uff09MSN-Pd\u3001MSN-Pd CD\u548cMSN-Pd\/CD@Neu\u7684Zeta\u7535\u4f4d\u3002<\/p>\n

\u56fe\u4e09\u3001\u624b\u6027\u4fee\u9970\u7684MSN-Pd\u50ac\u5316\u5242\u4fc3\u8fdbATH\u53cd\u5e94<\/strong>
\n \"\"\uff08A\uff09\u5229\u7528\u7532\u9178\u94a0\uff08HCOONa\uff09\u4f5c\u4e3a\u6c22\u4f9b\u4f53\uff0c\u5408\u6210\u624b\u6027HAA\uff1b<\/p>\n

\uff08B\uff09\u901a\u8fc7MSN-Pd\/CD\u50ac\u5316\u7684\u53cd\u5e94\u7269AA\u548c\u4ea7\u7269HAA\u76841H NMR\u8c31\u56fe\uff1b<\/p>\n

\uff08C\uff09\u6807\u51c6\u6d88\u65cb\u4f53HAA\u3001R-\u4ea7\u7269\u548cS-\u4ea7\u7269\u7684\u7532\u916f\u7684HPLC\u8272\u8c31\u56fe\uff0c\u540e\u4e24\u4e2a\u5206\u522b\u7531MSN-Pd\/CN\u548cMSN-Pd\/CD\u50ac\u5316\u3002<\/p>\n

\u56fe\u56db\u3001\u7532\u9178\u94a0\u4f5c\u4e3a\u6c22\u4f9b\u4f53\u80de\u5185\u5408\u6210\u624b\u6027IBU\u4ee5\u7f13\u89e3LPS\u8bf1\u5bfc\u7684\u708e\u75c7<\/strong>
\n \"\"\uff08A\uff09\u624b\u6027\u4fee\u9970\u7684MSN-Pd\u50ac\u5316\u5728RAW264.7\u7ec6\u80de\u4e2d\u5408\u6210IBU\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09\u901a\u8fc7\u9176\u8054\u514d\u75ab\u5438\u9644\u6d4b\u5b9a\uff08ELISA\uff09\u8bd5\u5242\u76d2\u5b9a\u91cfPGE2\u6c34\u5e73\uff1b<\/p>\n

\uff08C\uff09\u708e\u75c7\u6a21\u62df\u7ec6\u80de\u4e2d\u7684\u7ec6\u80de\u5185ROS\u6210\u50cf\uff1b<\/p>\n

\uff08D\uff09\u4ece\u6d41\u5f0f\u7ec6\u80de\u4eea\u5b9a\u91cfDCFH-DA\u7684\u5f52\u4e00\u5316\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

\uff08E\uff09MTT\u5206\u6790\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n

\u56fe\u4e94\u3001MSN-Pd\/CD@Neu\u5728\u708e\u75c7\u7ec6\u80de\u805a\u96c6\u5e76\u50ac\u5316ATH\u53cd\u5e94\u51cf\u8f7b\u708e\u75c7<\/strong>
\n \"\"\uff08A\uff09\u4e0eFITC\u6807\u8bb0\u7684Ly-6G\/Ly-6C\u548cPE\u6807\u8bb0\u7684CD11b\u6297\u4f53\u5171\u67d3\u8272\u7684LPS\u6fc0\u6d3b\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u7eaf\u5ea6\u7684\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\uff1b<\/p>\n

\uff08B\uff09\u672a\u6d3b\u5316\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u3001\u6d3b\u5316\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u7528PE\u6807\u8bb0\u7684CD11b\u6297\u4f53\u67d3\u8272\u7684MSN-Pd\/CD@Neu\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

\uff08C\uff09\u4e0e\u672a\u6fc0\u6d3b\u6216LPS\u6fc0\u6d3b\u7684RAW264.7\u7ec6\u80de\u5b75\u80b2\u7684MSN-Pd\/CD\u3001MSN-Pd\/CD@Neu\u548cMSN-Pd\/CD@RBC\u7684\u7ec6\u80de\u5185Pd\u6c34\u5e73\uff1b<\/p>\n

\uff08D\uff09PGE2\u7b49\u7ea7\u3002<\/p>\n

\u56fe\u516d\u3001MSN-Pd\/CD@Neu\u4e0e\u7532\u9178\u94a0\u7684\u4f53\u5185\u6297\u708e\u75c7\u6548\u679c<\/strong>
\n \"\"\uff08A\uff09LPS\u5f15\u8d77\u7684\u5c0f\u9f20\u53d1\u708e\u722a\u5b50\u7684ROS\u6210\u50cf\uff1b<\/p>\n

\uff08B\uff09ROS\u63a2\u9488DCFH-DA\u7684\u76f8\u5e94\u8367\u5149\u5f3a\u5ea6\u7684\u6807\u51c6\u5316\uff1b<\/p>\n

\uff08C\uff09PGE2\u7b49\u7ea7\uff1b<\/p>\n

\uff08D\uff09\u5c0f\u9f20\u53d1\u708e\u722a\u5b50\u7684H\uff06E\u67d3\u8272\u56fe\u50cf\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u5229\u7528\u751f\u7269\u6b63\u4ea4\u5316\u5b66\u5bf9\u4e2d\u6027\u7c92\u7ec6\u80de\u5b9a\u5411ATH\u53cd\u5e94\u8fdb\u884c\u9776\u5411\u4f4d\u70b9\u539f\u4f4d\u9009\u62e9\u6027\u5408\u6210\u624b\u6027\u836f\u7269\u7684\u65b0\u7b56\u7565\u3002\u9996\u5148\uff0c\u4f5c\u8005\u8bbe\u8ba1\u548c\u6784\u5efa\u4e86\u624b\u6027\u6539\u6027\u7684MSN-Pd\u50ac\u5316\u5242\uff0c\u8be5\u50ac\u5316\u5242\u80fd\u591f\u4ee5\u9ad8\u8f6c\u5316\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u50ac\u5316\u7ec6\u80de\u5185ATH\u53cd\u5e94\u3002\u63a5\u7740\uff0c\u4f5c\u8005\u5728\u53d1\u708e\u7684\u7ec6\u80de\u4e2d\u5408\u6210\u4e86\u624b\u6027\u836f\u7269IBU\uff0c\u963b\u6b62\u8fc7\u5ea6\u4ea7\u751f\u708e\u75c7\u56e0\u5b50PGE2\uff0c\u4ece\u800c\u7ef4\u6301\u6c27\u5316\u8fd8\u539f\u7a33\u6001\uff0c\u5e76\u6539\u5584\u7ec6\u80de\u5b58\u6d3b\u7387\u3002\u624b\u6027MSN-Pd\u50ac\u5316\u5242\u5728\u6297\u708e\u4f5c\u7528\u4e2d\u8868\u73b0\u51fa\u5bf9\u6620\u9009\u62e9\u6027\u3002\u4e3a\u4e86\u9009\u62e9\u6027\u5730\u589e\u52a0\u76ee\u6807\u90e8\u4f4d\u7684\u836f\u7269\u6d53\u5ea6\u5e76\u51cf\u5c11\u8131\u9776\u6548\u5e94\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u5229\u7528\u4e2d\u6027\u7c92\u7ec6\u80de\u819c\u5305\u88f9\u4e86MSN-Pd\u50ac\u5316\u5242\uff0c\u4ece\u800c\u901a\u8fc7\u9776\u5411\u7684ATH\u53cd\u5e94\uff0c\u539f\u4f4d\u5408\u6210S-IBU\u80fd\u591f\u51cf\u8f7b\u5c0f\u9f20\u722a\u5b50\u7684\u708e\u75c7\u53cd\u5e94\u3002\u603b\u4e4b\uff0c\u8be5\u5de5\u4f5c\u53ef\u80fd\u4f1a\u63d0\u4f9b\u9488\u5bf9\u6027\u7684\u751f\u7269\u6b63\u4ea4\u5316\u5b66\u4e0e\u624b\u6027\u836f\u7269\u5408\u6210\u7684\u65b0\u601d\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aNeutrophil-Membrane-Directed Bioorthogonal Synthesis of Inflammation-Targeting Chiral Drugs<\/a>.<\/strong> (Chem<\/em>, 2020<\/strong>, DOI: https:\/\/doi.org\/10.1016\/j.chempr.2020.06.002)
\n <\/strong><\/p>\n

\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n

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