{"id":204226,"date":"2020-06-29T06:30:05","date_gmt":"2020-06-28T22:30:05","guid":{"rendered":"\/\/m.iemloyee.com\/?p=204226"},"modified":"2020-06-29T20:51:20","modified_gmt":"2020-06-29T12:51:20","slug":"%e4%b8%8a%e7%a7%91%e5%a4%a7vs%e5%8d%97%e7%a7%91%e5%a4%a7%ef%bc%8c%e8%b6%85%e5%b9%b4%e8%bd%bb%e7%9a%84%e9%bb%91%e9%a9%ac%e9%ab%98%e6%a0%a1%e5%8f%91science-nature%e5%88%b0%e6%89%8b%e8%bd%af","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=204226","title":{"rendered":"\u4e0a\u79d1\u5927VS\u5357\u79d1\u5927\uff0c\u8d85\u5e74\u8f7b\u7684\u9ed1\u9a6c\u9ad8\u6821\u53d1Science 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href=\"https:\/\/baike.baidu.com\/item\/%E7%89%B9%E8%81%98%E6%95%99%E6%8E%88\/7517413\">\u6388<\/a>282\u4f4d\uff0c\u5e38\u4efb\u6559\u6388\u5230\u4f4d211\u4f4d\uff09\uff0c\u5176\u4e2d\u5305\u62ec\u8bfa\u8d1d\u5c14\u5956\u83b7\u5f97\u80055\u4f4d\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb32\u4f4d\u3001\u4e2d\u56fd\u5de5\u7a0b\u9662\u9662\u58eb3\u4f4d\u3001\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb11\u4f4d\u3001\u7f8e\u56fd\u4eba\u6587\u4e0e\u79d1\u5b66\u9662\u9662\u58eb8\u4eba\u3001\u82f1\u56fd\u7687\u5bb6\u5b66\u4f1a\u9662\u58eb3\u4f4d\u3001\u56fd\u5bb6\u6770\u51fa\u9752\u5e74\u79d1\u5b66\u57fa\u91d1\u83b7\u5f97\u800599\u4f4d\u3002<\/p>\n<p>\u5357\u79d1\u5927\uff1a\u5357\u65b9\u79d1\u6280\u5927\u5b66\u662f\u56fd\u5bb6\u9ad8\u7b49\u6559\u80b2\u7efc\u5408\u6539\u9769\u8bd5\u9a8c\u6821\u3001\u6df1\u5733\u5e02\u521b\u529e\u7684\u4e00\u6240\u521b\u65b0\u578b\u5927\u5b66\uff0c\u76ee\u6807\u662f\u8fc5\u901f\u5efa\u6210\u56fd\u9645\u5316\u9ad8\u6c34\u5e73\u7814\u7a76\u578b\u5927\u5b66\u30022010\u5e7412\u6708\uff0c\u6559\u80b2\u90e8\u540c\u610f\u7b79\u5efa\u5357\u65b9\u79d1\u6280\u5927\u5b66\u30022012\u5e744\u6708\uff0c\u6559\u80b2\u90e8\u540c\u610f\u5efa\u7acb\u5357\u65b9\u79d1\u6280\u5927\u5b66\uff0c\u5e76\u8d4b\u4e88\u5b66\u6821\u63a2\u7d22\u5177\u6709\u4e2d\u56fd\u7279\u8272\u7684\u73b0\u4ee3\u5927\u5b66\u5236\u5ea6\u3001\u63a2\u7d22\u521b\u65b0\u4eba\u624d\u57f9\u517b\u6a21\u5f0f\u7684\u76ee\u68072018\u5e745\u6708\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u83b7\u6279\u535a\u58eb\u5b66\u4f4d\u6388\u4e88\u5355\u4f4d\uff0c\u6210\u4e3a\u56fd\u5185\u6700\u5feb\u83b7\u5f97\u535a\u58eb\u6388\u6743\u5355\u4f4d\u7684\u9ad8\u6821\u3002\u6cf0\u6664\u58eb\u4e9a\u6d32\u5927\u5b66\u6392\u540d\u4e2d\u5357\u65b9\u79d1\u6280\u5927\u5b66\u6392\u5728\u7b2c\u516b\u4f4d\uff0c\u4ec5\u6b21\u4e8e\u6e05\u534e\u5317\u5927\u548c\u534e\u4e1c\u4e94\u6821\uff0c \u622a\u81f32020\u5e745\u6708\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u5df2\u7b7e\u7ea6\u5f15\u8fdb\u6559\u5e08981\u4eba\uff0c\u5305\u62ec\u9662\u58eb45\u4eba\uff08\u7b7e\u7ea6\u5f15\u8fdb\u4e0e\u81ea\u4e3b\u57f9\u517b\u5168\u804c\u9662\u58eb20\u4eba\uff09\uff0c\u56fd\u9645\u4f1a\u58eb35\u4eba\uff0c \u6559\u80b2\u90e8\u7279\u8058\u4e13\u5bb628\u4eba\uff0c\u201c\u56fd\u5bb6\u7279\u652f\u8ba1\u5212\u201d\u4e13\u5bb611\u4eba\u3001\u201c\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u201d\u83b7\u5f97\u800529\u4eba\u3001\u201c\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u4f18\u79c0\u9752\u5e74\u57fa\u91d1\u201d\u83b7\u5f97\u800510\u4eba\u3002<\/p>\n<p>\u867d\u7136\u8fd9\u4e24\u6240\u9ad8\u6821\u4e00\u4e2a6\u5c81\uff0c\u4e00\u4e2a8\u5c81\uff0c\u4f46\u662f\u79d1\u7814\u5b9e\u529b\u4e0d\u5bb9\u5c0f\u89d1\uff0c\u77ed\u77ed\u7684\u51e0\u4e2a\u6708\u91cc\uff0c\u5728Nature \/Science\u91cc\u53d1\u6587\u5230\u624b\u8f6f\uff0c\u4e0b\u9762\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e0b\u5177\u4f53\u6210\u679c\uff0c\u4f9b\u5927\u5bb6\u5b66\u4e60\u3002<\/p>\n<p><strong><b>N<\/b><\/strong><strong><b>S<\/b><\/strong><strong><b>\u6210\u679c\u6c47\u603b<\/b><\/strong><\/p>\n<p><strong><b>\u5357\u79d1\u5927\uff1a<\/b><\/strong><\/p>\n<p><strong><b>N<\/b><\/strong><strong><b>ature<\/b><\/strong><strong><b>: <\/b><\/strong><strong><b>\u690d\u7269\u5185\u6e9022nt siRNA\u4ecb\u5bfc\u7ffb\u8bd1\u6291\u5236\u4e0e\u80c1\u8feb\u9002\u5e94\u6027<\/b><\/strong><\/p>\n<p>siRNAs\u5bf9\u771f\u6838\u7ec6\u80de\u7684\u6b63\u5e38\u53d1\u80b2\u548c\u514d\u75ab\u81f3\u5173\u91cd\u8981\u3002\u690d\u7269\u4f53\u5185\u53ef\u4ee5\u4ea7\u751f\u957f\u5ea6\u4e3a21\u300122\u621624\u4e2a\u6838\u82f7\u9178(nt)\u5355\u4f4d\u7684siRNAs\u300221nt\u548c24nt\u00a0siRNAs\u7684\u79cd\u7c7b\u4ecb\u5bfc\u4fe1\u4f7fRNA\u7684\u88c2\u89e3\u548cDNA\u7532\u57fa\u5316\uff0c\u4f46\u517622nt\u00a0siRNAs\u751f\u7269\u5b66\u529f\u80fd\u4ecd\u7136\u672a\u77e5\u3002\u5728\u6b64\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u90ed\u7ea2\u536b\u6559\u6388\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u690d\u7269\u4e2dDICER-LIKE 2 (DCL2)\u86cb\u767d\u4ea7\u751f\u7684\u4e00\u7ec4\u5185\u6e90\u602722nt siRNAs\u7684\u9274\u5b9a\u3002\u5f53\u7ec6\u80de\u8d28RNA\u8870\u53d8\u65f6DCL4\u662f\u654f\u611f\u7684\uff0c\u7531\u6b64\u4ea7\u751f\u768422nt siRNAs\u7684\u5927\u91cf\u79ef\u7d2f\u4f1a\u5bfc\u81f4\u591a\u5411\u6027\u751f\u957f\u969c\u788d\uff0c\u5305\u62ec\u4e25\u91cd\u7684\u77ee\u5316\u3001\u5206\u751f\u7ec4\u7ec7\u7f3a\u9677\u548c\u8272\u7d20\u6c89\u7740\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u53c2\u4e0e\u6c2e\u4ee3\u8c22\u7684\u785d\u9178\u8fd8\u539f\u9176\u57fa\u56e0\uff08NIA1\u548cNIA2\uff09\u4ea7\u751f\u768422nt siRNA\u7ea6\u5360\u603b22nt siRNA\u7684\u4e00\u534a\u300222nt\u00a0siRNAs\u7684\u4ea7\u751f\u53ef\u4ee5\u5728\u7279\u5b9a\u7684RNA\u964d\u89e3\u7f3a\u5931\u60c5\u51b5\u4e0b\u4ea7\u751f\u5e76\u5927\u91cf\u6269\u589e\uff0c\u5e76\u901a\u8fc7\u6291\u5236\u9776\u6807mRNA\u7684\u7ffb\u8bd1\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b22nt siRNAs\u5728\u73af\u5883\u80c1\u8feb\u4e0b\u4f1a\u4f18\u5148\u79ef\u7d2f\uff0c\u7279\u522b\u662f\u6765\u81eaNIA1\/2\u7684siRNAs\uff0c\u53ef\u4ee5\u6291\u5236\u7ffb\u8bd1\uff0c\u6291\u5236\u690d\u7269\u751f\u957f\uff0c\u589e\u5f3a\u80c1\u8feb\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u76f8\u5173\u7814\u7a76\u63ed\u793a\u4e8622nt siRNAs\u7684\u72ec\u7279\u7279\u6027\uff0c\u5e76\u63ed\u793a\u4e86\u5b83\u4eec\u5728\u690d\u7269\u9002\u5e94\u73af\u5883\u80c1\u8feb\u4e2d\u7684\u91cd\u8981\u6027\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cPlant 22-nt siRNAs mediate translational repression and stress adaptation\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Nature\u4e0a\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1aDOI: 10.1038\/s41586-020-2231-y<\/p>\n<p>\u56fe1\u00a0ein5 dcl4\u548cski2\u00a0dcl4\u53cc\u7a81\u53d8\u4f53\u4e2d\u4ea7\u751f\u5927\u91cf22nt siRNA\uff0c\u5e76\u4ecb\u5bfc\u7ffb\u8bd1\u6291\u5236<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-204228 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72471-28.png\" alt=\"\" width=\"700\" height=\"393\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72471-28.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72471-28-300x168.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p><strong><b>N<\/b><\/strong><strong><b>ature<\/b><\/strong><strong><b>: <\/b><\/strong><strong><b>\u9ad8\u6307\u6570\u6676\u9762\u3001A4\u7eb8\u5c3a\u5bf8\u5355\u6676\u94dc\u7b94\u5e93\u5236\u9020<\/b><\/strong><\/p>\n<p>\u7531\u4e8e\u5176\u5728\u6676\u4f53\u5916\u5ef6\u3001\u50ac\u5316\u3001\u70ed\u7535\u7b49\u9886\u57df\u7684\u6f5c\u5728\u5e94\u7528\uff0c\u5236\u5907\u5404\u79cd\u9762\u5f62\u6307\u6570\u7684\u5927\u578b\u5355\u6676\u91d1\u5c5e\u7b94\u4e00\u76f4\u662f\u6750\u6599\u79d1\u5b66\u7684\u7814\u7a76\u70ed\u70b9\u3002\u5bf9\u4e8e\u91d1\u5c5e\u6765\u8bf4\uff0c\u4f4e\u6307\u6570\u6676\u9762\u4ec5\u6709\u4e09\u79cd({100}, {110} and {111})\uff0c\u800c\u4e0e\u6b64\u76f8\u6bd4\uff0c\u9ad8\u6307\u6570\u6676\u9762\u5219\u6709\u65e0\u9650\u79cd\uff0c\u56e0\u6b64\u5177\u6709\u66f4\u52a0\u4e30\u5bcc\u7684\u8868\u9762\u548c\u6027\u80fd\u3002\u7136\u800c\uff0c\u4e0d\u7ba1\u662f\u70ed\u529b\u5b66\u8fd8\u662f\u52a8\u529b\u5b66\u89d2\u5ea6\u91d1\u5c5e\u90fd\u66f4\u503e\u5411\u4e8e\u5f62\u6210\u4f4e\u6307\u6570\u6676\u9762\uff0c\u56e0\u6b64\u53ef\u63a7\u5236\u5907\u9ad8\u6307\u6570\u6676\u9762\u7684\u5355\u6676\u91d1\u5c5e\u7b94\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\u3002\u5728\u6b64\uff0c\u97e9\u56fd\u851a\u5c71\u79d1\u5b66\u6280\u672f\u9662\u7684\u4e01\u5cf0\u3001\u5357\u65b9\u79d1\u6280\u5927\u5b66\u7684\u4fde\u5927\u9e4f\u9662\u58eb\u4ee5\u53ca\u5317\u4eac\u5927\u5b66\u7684\u738b\u6069\u54e5\u9662\u58eb\u3001\u5218\u5f00\u8f89\u7814\u7a76\u5458\u7b49\u4eba\u62a5\u9053\u4e86\u4e00\u79cd\u5236\u5907\u591a\u79cd\u5355\u6676\u94dc\u7b94\u7684\u6676\u79cd\u751f\u957f\u6280\u672f\u3002\uff0c\u4ee5\u6b64\u5236\u5907\u7684\u5355\u6676\u94dc\u7b94\u5927\u5c0f\u7ea630\u00d720\u5e73\u65b9\u5398\u7c73\uff0c\u6676\u9762\u8fbe30\u591a\u79cd\u3002\u5bf9\u591a\u6676\u94dc\u7b94\u8fdb\u884c\u6e29\u548c\u7684\u9884\u6c27\u5316\uff0c\u7136\u540e\u5728\u8fd8\u539f\u6c14\u6c1b\u4e2d\u9000\u706b\uff0c\u5bfc\u81f4\u9ad8\u6307\u6570\u94dc\u5207\u9762\u7684\u751f\u957f\uff0c\u51e0\u4e4e\u8986\u76d6\u4e86\u6574\u4e2a\u7b94\uff0c\u5e76\u6709\u53ef\u80fd\u751f\u957f\u5230\u6570\u7c73\u957f\u7684\u957f\u5ea6\u3002\u5728\u7b94\u7247\u4e0a\u6c27\u5316\u5c42\u7684\u4ea7\u751f\u610f\u5473\u7740\u8868\u9762\u80fd\u91cf\u7684\u6700\u5c0f\u5316\u5e76\u4e0d\u662f\u6676\u9762\u751f\u957f\u9009\u62e9\u7684\u5173\u952e\u51b3\u5b9a\u56e0\u7d20\u3002\u76f8\u53cd\uff0c\u6676\u9762\u9009\u62e9\u662f\u7531\u6700\u5927\u6676\u7c92\u7684\u6676\u9762\u968f\u673a\u51b3\u5b9a\u7684(\u4e0e\u5b83\u7684\u8868\u9762\u80fd\u91cf\u65e0\u5173)\uff0c\u8fd9\u5c06\u6d88\u8017\u66f4\u5c0f\u7684\u6676\u7c92\u5e76\u6d88\u9664\u6676\u754c\u3002\u8fd9\u9879\u751f\u957f\u6280\u672f\u4e0d\u4ec5\u53ef\u4ee5\u5236\u5907\u94dc\u7b94\uff0c\u8fd8\u80fd\u5236\u5907\u9ad8\u6307\u6570\u5355\u6676\u954d\u7b94\uff0c\u662f\u4e00\u79cd\u901a\u7528\u7684\u6750\u6599\u5236\u5907\u624b\u6bb5\u3002\u7814\u7a76\u8ba4\u4e3a\u8fd9\u4e00\u591a\u6676\u9762\u91d1\u5c5e\u7b94\u5728\u4e8c\u7ef4\u6750\u6599\u5236\u5907\u3001\u9009\u62e9\u6027\u50ac\u5316\u7b49\u65b9\u9762\u5747\u6709\u6f5c\u5728\u7684\u5e94\u7528\u4ef7\u503c\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201c Seeded growth of large single-crystal copper foils with high-index facets\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728 Nature\u4e0a\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1aDOI: 10.1038\/ s41586-020-2298-5<\/p>\n<p>\u56fe2\u00a0A4\u7eb8\u5c3a\u5bf8\u7684\u591a\u6676\u9762\u5355\u6676\u94dc\u7b94<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-204227 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe2.png\" alt=\"\" width=\"700\" height=\"432\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe2.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe2-300x185.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p><strong><b>S<\/b><\/strong><strong><b>cie<\/b><\/strong><strong><b>nce:<\/b><\/strong><strong><b>\u00a0\u5316\u5b66\u53cd\u5e94\u4e2d\u7684\u91cf\u5b50\u51e0\u4f55\u76f8\u4f4d\u6548\u5e94<\/b><\/strong><\/p>\n<p>\u7406\u89e3\u91cf\u5b50\u5e72\u6d89\u5bf9\u5316\u5b66\u53cd\u5e94\u52a8\u529b\u5b66\u7684\u7814\u7a76\u81f3\u5173\u91cd\u8981\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u5927\u8fde\u5316\u5b66\u7269\u7406\u7814\u7a76\u6240\u3001\u5357\u65b9\u79d1\u6280\u5927\u5b66\u6768\u5b66\u660e\u9662\u58eb\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5927\u8fde\u5316\u5b66\u7269\u7406\u7814\u7a76\u6240\u5f20\u4e1c\u8f89\u9662\u58eb\uff0c\u5b59\u5fd7\u521a\u7814\u7a76\u5458\u548c\u8096\u6625\u96f7\u7814\u7a76\u5458\u7814\u7a76\u56e2\u961f\u5728\u6c22\u539f\u5b50\u4e0e\u6c22\u5206\u5b50\u7684\u540c\u4f4d\u7d20\uff08H+HD\u2192H<sub>2<\/sub>+D\uff09\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u53d1\u73b0\u4e86\u65b0\u7684\u91cf\u5b50\u5e72\u6d89\u73b0\u8c61\uff0c\u5e76\u63ed\u793a\u4e86\u8be5\u53cd\u5e94\u4e2d\u7684\u91cf\u5b50\u51e0\u4f55\u76f8\u4f4d\u6548\u5e94\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u540e\u5411\u6563\u5c04\u89d2\u5ea6\u4e0a\uff0c\u4ea7\u7269H<sub>2<\/sub>\u4f1a\u968f\u78b0\u649e\u80fd\u53d8\u5316\u800c\u5448\u73b0\u51fa\u6709\u89c4\u5f8b\u7684\u632f\u8361\u3002\u62d3\u6251\u5b66\u5206\u6790\u8868\u660e\uff0c\u8fd9\u4e9b\u540e\u5411\u6563\u5c04\u7684\u632f\u8361\u5b9e\u9645\u4e0a\u662f\u7531\u4e24\u6761\u53cd\u5e94\u9014\u5f84\u7684\u5e72\u6d89\u9020\u6210\u7684\u3002\u5b83\u4eec\u5404\u81ea\u7684\u5e45\u5ea6\u968f\u7740\u78b0\u649e\u80fd\u53d8\u5316\u5e76\u672a\u663e\u8457\u53d8\u5316\uff0c\u4f46\u5b83\u4eec\u7684\u76f8\u4f4d\u5374\u968f\u7740\u78b0\u649e\u80fd\u53d8\u5316\uff0c\u4e00\u4e2a\u5448\u7ebf\u6027\u589e\u52a0\uff0c\u53e6\u4e00\u4e2a\u5448\u7ebf\u6027\u51cf\u5c11\u3002\u7531\u4e8e\u8fd9\u4e2a\u539f\u56e0\uff0c\u5b83\u4eec\u76f8\u4e92\u5e72\u6d89\u7684\u7ed3\u679c\u4fbf\u5448\u73b0\u51fa\u4e86\u6709\u89c4\u5f8b\u7684\u632f\u8361\u73b0\u8c61\u3002\u8fdb\u4e00\u6b65\u91c7\u7528\u7ecf\u5178\u8f68\u7ebf\u7406\u8bba\u5206\u6790\u8868\u660e\uff0c\u5176\u4e2d\u4e00\u6761\u53cd\u5e94\u9014\u5f84\u5bf9\u5e94\u4e8e\u901a\u5e38\u6240\u719f\u77e5\u7684\u76f4\u63a5\u53cd\u5e94\u8fc7\u7a0b\uff1b\u800c\u53e6\u4e00\u6761\u53cd\u5e94\u9014\u5f84\u5bf9\u5e94\u4e8e\u7c7b\u4f3c\u4e8e\u6f2b\u6e38(roaming)\u673a\u7406\u7684\u53cd\u5e94\u8fc7\u7a0b\u3002\u4e24\u6761\u53cd\u5e94\u9014\u5f84\u4ee5\u76f8\u53cd\u7684\u65b9\u5411\u56f4\u7ed5\u4e8eH+HD\u53cd\u5e94\u52bf\u80fd\u9762\u4e0a\u7684\u9525\u5f62\u4ea4\u53c9\uff0c\u5e72\u6d89\u56fe\u6837\u901a\u8fc7\u51e0\u4f55\u76f8\u4f4d\u6548\u5e94\u5f97\u4ee5\u53d1\u73b0\u3002\u66f4\u6709\u8da3\u7684\u662f\uff0c\u5728\u6240\u7814\u7a76\u7684\u78b0\u649e\u80fd\u8303\u56f4\u5185\uff0c\u901a\u8fc7\u6f2b\u6e38\u673a\u7406\u6240\u53d1\u751f\u7684\u53cd\u5e94\u53ea\u5360\u5168\u90e8\u53cd\u5e94\u6027\u76840.3%\u5de6\u53f3\u3002\u4f46\u5982\u6b64\u5fae\u5f31\u7684\u5c0f\u90e8\u5206\u53cd\u5e94\u6027\uff0c\u5374\u80fd\u591f\u6e05\u6670\u5730\u88ab\u7406\u8bba\u548c\u5b9e\u9a8c\u6240\u63ed\u793a\u51fa\u6765\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cQuantum interference in H + HD \u2192 H<sub>2<\/sub>\u00a0+ D between direct abstraction and roaming insertion pathways\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Science\u4e0a\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1aDOI: 10.1126\/science.abb1564 \u00a0<\/p>\n<p>\u56fe3\u00a0H + HD\u2192H<sub>2<\/sub>\u00a0+ D\u53cd\u5e94D\u539f\u5b50\u4ea7\u7269\u7684TOF\u8c31<strong><b><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-204229 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72473-26.png\" alt=\"\" width=\"700\" height=\"984\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72473-26.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72473-26-213x300.png 213w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/b><\/strong><\/p>\n<p><strong><b>Science\uff1a<\/b><\/strong><strong><b>\u79bb\u5b50\u660e\u80f6\u5728\u5ba4\u6e29\u4e0b\u5177\u6709\u5de8\u5927\u7684\u70ed\u7535\u52bf<\/b><\/strong><\/p>\n<p>\u4ece\u73af\u5883\u4e2d\u6536\u96c6\u80fd\u91cf\u5e76\u8f6c\u5316\u4e3a\u7535\u80fd\u4e3a\u7269\u8054\u7f51\u4f20\u611f\u5668\u63d0\u4f9b\u7535\u80fd\u7684\u53d1\u5c55\u4e2d\u6709\u91cd\u8981\u610f\u4e49\uff0c\u901a\u8fc7\u8fd9\u79cd\u4f9b\u7535\u4f5c\u7528\u80fd\u591f\u4f7f\u5176\u514d\u4e8e\u7535\u7f06\/\u7535\u6c60\u4f9b\u7535\uff0c\u652f\u6301\u4e86\u53ef\u7a7f\u6234\u8bbe\u5907\u7684\u53d1\u5c55\u3002\u70ed\u7535\u6750\u6599\u5668\u4ef6\u4e2d\uff0c\u901a\u8fc7\u79bb\u5b50\u4f5c\u4e3a\u8f7d\u6d41\u5b50\uff0c\u901a\u5e38\u9700\u8981\u5728\u4e0d\u540c\u6e29\u5ea6\u4e2d\u5728\u4e24\u4e2a\u7535\u6781\u4e4b\u95f4\u8fdb\u884c\u70ed\u6269\u6563\u6216\u8fd8\u539f\u53cd\u5e94\u3002\u5357\u65b9\u79d1\u6280\u5927\u5b66\u5218\u73ae\u4e66\u3001\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u9648\u521a\u6559\u6388\u7b49\u53d1\u5c55\u4e86\u4e00\u79cd\u57fa\u4e8e\u660e\u80f6\uff08gelatin\uff09\u7684\u5668\u4ef6\uff0c\u901a\u8fc7\u78b1\u91d1\u5c5e\u76d0\u548c\u94c1\u57fa\u8fd8\u539f\u5bf9\u914d\u5408\uff0c\u4ea7\u751f\u4e86\u4e00\u4e2a\u975e\u5e38\u5927\u7684\u70ed\u7535\u8f6c\u5316\u6548\u679c\u3002\u5e76\u4e14\u8be5\u88c5\u7f6e\u901a\u8fc7\u8eab\u4f53\u4e0a\u53d1\u70ed\u5c31\u80fd\u591f\u5f97\u5230\u8db3\u591f\u7684\u80fd\u91cf\u3002\u5236\u6210\u7684\u5668\u4ef6\u4e2d\u6700\u9ad8\u7684\u70ed\u7535\u80fd\u8fbe\u523017.0 mV\/K\uff0c\u660e\u80f6\u4e2d\u7684\u79bb\u5b50\u4f20\u8f93\u901a\u8fc7KCl\uff0cNaCl\uff0cKNO<sub>3<\/sub>\u8fdb\u884c\u70ed\u6269\u6563\u4f5c\u7528\uff0c\u5e76\u901a\u8fc7[Fe(CN)<sub>6<\/sub><sup>4-<\/sup>\/Fe(CN)<sub>6<\/sub><sup>3-<\/sup>]\u63d0\u5347\u70ed\u7535\u6548\u5e94\u3002\u5f53\u901a\u8fc7\u8eab\u4f53\u70ed\u80fd\u4f5c\u4e3a\u70ed\u6e90\u7684\u53ef\u7a7f\u6234\u5668\u4ef6\u4e2d\u5c31\u53ef\u4ee5\u8fbe\u52302 V\u7684\u70ed\u7535\u6548\u5e94\u548c\u6700\u9ad85mW\u7684\u529f\u7387\u3002\u8fd9\u79cd\u79bb\u5b50\u578b\u660e\u80f6\u5c55\u73b0\u51fa\u79bb\u5b50\u80fd\u91cf\u8f7d\u4f53\u5728\u70ed\u7535\u8f6c\u6362\u4e2d\u7684\u91cd\u8981\u5e94\u7528\u524d\u666f\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cGiant thermopower of ionic gelatin near room temperature\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Science\u4e0a\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1aDOI: 10.1126\/science.aaz5045<\/p>\n<p>\u56fe4\u00a0i-TE\u6750\u6599\u7684\u5de8\u5927\u70ed\u7535\u6027\u8d28<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-204230 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72474-25.png\" alt=\"\" width=\"700\" height=\"820\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72474-25.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72474-25-256x300.png 256w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p><strong><b>\u4e0a\u79d1\u5927\uff1a<\/b><\/strong><\/p>\n<p><strong><b>Nature\uff1a<\/b><\/strong><strong><b>\u4e8c\u7ef4\u5364\u5316\u7269\u9499\u949b\u77ff<\/b><\/strong><strong><b>\u6a2a<\/b><\/strong><strong><b>\u5411\u5916\u5ef6\u5f02\u8d28\u7ed3<\/b><\/strong><\/p>\n<p>\u4e8c\u7ef4\u5364\u5316\u7269\u9499\u949b\u77ff\u7531\u4e8e\u5176\u7ed3\u6784\u548c\u7ec4\u6210\u7684\u7075\u6d3b\u6027\uff0c\u4f7f\u5f97\u5176\u5177\u6709\u8f83\u9ad8\u7684\u5149\u81f4\u53d1\u5149\u91cf\u5b50\u6548\u7387\u3001\u8f83\u957f\u7684\u8f7d\u6d41\u5b50\u5bff\u547d\u548c\u6269\u6563\u957f\u5ea6\uff0c\u4ee5\u53ca\u663e\u8457\u7684\u5149\u7535\u53ef\u8c03\u8c10\u6027\u3002\u540c\u65f6\u8fd9\u4e9b2D\u9499\u949b\u77ff\u5728\u6cbf\u9762\u5916\u65b9\u5411\u5468\u671f\u6027\u5f62\u6210\u4e86\u7531\u6709\u673a\u548c\u65e0\u673a\u5c42\u6784\u6210\u7684\u91cf\u5b50\u9631\u7ed3\u6784\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u4e86\u7ed3\u6784\u548c\u6027\u80fd\u7684\u53ef\u8c03\u8c10\u6027\uff0c\u4f7f\u5176\u5728\u592a\u9633\u80fd\u7535\u6c60\u3001\u53d1\u5149\u5668\u4ef6\u3001\u63a2\u6d4b\u5668\u7b49\u5e94\u7528\u65b9\u9762\u5177\u6709\u6781\u5927\u7684\u5438\u5f15\u529b\uff0c\u4f46\u5364\u5316\u7269\u9499\u949b\u77ff\u7684\u539f\u5b50\u7ea7\u7684\u5f02\u8d28\u7ed3\u6784\u5916\u5ef6\u751f\u957f\u5c1a\u672a\u5b9e\u73b0\uff0c\u539f\u56e0\u5728\u4e8e\u5176\u56fa\u6709\u7684\u79bb\u5b50\u8fc1\u79fb\u7387\uff0c\u5bfc\u81f4\u76f8\u4e92\u6269\u6563\uff1b\u540c\u65f6\u5316\u5b66\u7a33\u5b9a\u6027\u5dee\uff0c\u4f7f\u5f97\u5728\u540e\u7eed\u5236\u9020\u4e2d\u5bb9\u6613\u7834\u574f\u4e4b\u524d\u5df2\u5236\u5907\u7684\u6750\u6599\u3002\u56e0\u6b64\uff0c\u4e86\u89e3\u8fd9\u79cd\u4e0d\u7a33\u5b9a\u6027\u7684\u4ea7\u751f\u7684\u6839\u6e90\uff0c\u5e76\u5236\u5b9a\u6709\u6548\u7684\u65b9\u6cd5\u6765\u6291\u5236\u79bb\u5b50\u6269\u6563\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002\u5728\u8fd9\u91cc\uff0c\u7f8e\u56fd\u666e\u6e21\u5927\u5b66\u7aa6\u4e50\u6dfb\u6559\u6388\u548cBrett M. Savoie\u6559\u6388\u8054\u5408\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u4e8e\u5955\u6559\u6388\u62a5\u544a\u4e86\u4e00\u79cd\u6709\u6548\u7684\u7b56\u7565\uff0c\u901a\u8fc7\u52a0\u5165\u521a\u6027\u03c0-\u5171\u8f6d\u6709\u673a\u914d\u4f53\uff0c\u6291\u5236\u4e86\u4e8c\u7ef4\u5364\u5316\u7269\u9499\u949b\u77ff\u7684\u5e73\u9762\u5185\u79bb\u5b50\u6eb6\u89e3\u3002\u7814\u7a76\u5c55\u793a\u4e86\u9ad8\u5ea6\u7a33\u5b9a\u548c\u53ef\u8c03\u8c10\u7684\u6a2a\u5411\u5916\u5ef6\u5f02\u8d28\u7ed3\u6784\u3001\u591a\u5f02\u8d28\u7ed3\u6784\u548c\u8d85\u6676\u683c\u3002\u901a\u8fc7\u4f4e\u5242\u91cf\u50cf\u5dee\u6821\u6b63\u7684\u9ad8\u5206\u8fa8\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u5c55\u73b0\u4e86\u8fd1\u539f\u5b50\u7ea7\u754c\u9762\u7684\u89c2\u5bdf\u548c\u5916\u5ef6\u751f\u957f\u7684\u673a\u7406\u5206\u6790\u3002\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u7814\u7a76\u4e86\u5171\u8f6d\u914d\u4f53\u5b58\u5728\u65f6\uff0c\u4e8c\u7ef4\u9499\u949b\u77ff\u5f02\u8d28\u7ed3\u6784\u65e0\u5e8f\u6027\u7684\u964d\u4f4e\u548c\u7a7a\u4f4d\u5f62\u6210\u80fd\u7684\u589e\u5927\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u5364\u5316\u7269\u9499\u949b\u77ff\u534a\u5bfc\u4f53\u7684\u7a33\u5b9a\u63d0\u4f9b\u4e86\u89c1\u89e3\uff0c\u5e76\u4e3a\u590d\u6742\u548c\u5206\u5b50\u8584\u8d85\u6676\u683c\u3001\u5668\u4ef6\u548c\u96c6\u6210\u7535\u8def\u6f14\u793a\u4e86\u6750\u6599\u5e73\u53f0\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cTwo-dimensional halide perovskite lateral epitaxial heterostructures\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Nature\u4e0a\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1aDOI:\u00a010.1038\/s41586-020-2219-7<\/p>\n<p>\u56fe5\u00a0\u5171\u8f6d\u914d\u4f53\u7a33\u5b9a\u7684\u4e8c\u7ef4\u5364\u5316\u7269\u9499\u949b\u77ff\u6a2a\u5411\u5f02\u8d28\u7ed3\u6784<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-204231 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72475-24.png\" alt=\"\" width=\"700\" height=\"587\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72475-24.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72475-24-300x252.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p><strong><b>Nature\uff1a\u53d7\u884c\u4e3a\u5f71\u54cd\u7684\u8111\u6d3b\u52a8\u8c03\u63a7\u4f53\u6db2\u514d\u75ab\u5e94\u7b54<\/b><\/strong><\/p>\n<p>\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u80e1\u9701\u8bfe\u9898\u7ec4\u548c\u6e05\u534e\u5927\u5b66\u7941\u6d77\u8bfe\u9898\u7ec4\u3001\u9ea6\u6208\u6587\u8111\u79d1\u5b66\u7814\u7a76\u6240\u949f\u6bc5\u8bfe\u9898\u7ec4\u5408\u4f5c\uff0c\u5c0f\u9f20\u6a21\u578b\u901a\u8fc7\u8bc6\u522b\u4e00\u79cd\u7279\u6b8a\u7684\u8111\u813e\u795e\u7ecf\u8fde\u63a5\uff0c\u8fd9\u79cd\u795e\u7ecf\u8fde\u63a5\u53ef\u4ee5\u81ea\u4e3b\u5730\u589e\u5f3a\u4f53\u6db2\u53cd\u5e94\uff0c\u5e76\u901a\u8fc7\u8eab\u4f53\u884c\u4e3a\u8bc1\u660e\u514d\u75ab\u523a\u6fc0\uff0c\u7814\u7a76\u63ed\u793a\u4e86\u5927\u8111\u5bf9\u9002\u5e94\u6027\u514d\u75ab\u7684\u63a7\u5236\uff0c\u5e76\u63d0\u51fa\u4e86\u901a\u8fc7\u884c\u4e3a\u5e72\u9884\u6765\u589e\u5f3a\u514d\u75ab\u80fd\u529b\u7684\u53ef\u80fd\u6027\u3002\uff0c\u8be5\u7814\u7a76\u53d1\u73b0\u4e86\u4e00\u6761\u4ece\u5927\u8111\u674f\u4ec1\u6838\u548c\u5ba4\u65c1\u6838CRH\u795e\u7ecf\u5143\u5230\u813e\u5185\u7684\u795e\u7ecf\u901a\u8def\u3002\u8fd9\u6761\u901a\u8def\u4fc3\u8fdb\u75ab\u82d7\u63a5\u79cd\u5f15\u8d77\u7684\u6297\u4f53\u514d\u75ab\u5e94\u7b54\uff0c\u5e76\u53ef\u901a\u8fc7\u54cd\u5e94\u8eaf\u4f53\u884c\u4e3a\u523a\u6fc0\u5bf9\u514d\u75ab\u5e94\u7b54\u8fdb\u884c\u4e0d\u540c\u8c03\u63a7\u3002\u8fd9\u662f\u8fc4\u4eca\u53d1\u73b0\u7684\u7b2c\u4e00\u6761\u89e3\u5256\u5b66\u660e\u786e\u3001\u7531\u795e\u7ecf\u4fe1\u53f7\u4f20\u9012\u800c\u975e\u5185\u5206\u6ccc\u6fc0\u7d20\u4ecb\u5bfc\u7684\u3001\u4e2d\u67a2\u795e\u7ecf\u5bf9\u9002\u5e94\u6027\u514d\u75ab\u5e94\u7b54\u8fdb\u884c\u8c03\u63a7\u7684\u901a\u8def\uff0c\u5b83\u7684\u53d1\u73b0\u4e3a\u795e\u7ecf\u514d\u75ab\u5b66\u7814\u7a76\u62d3\u5c55\u51fa\u4e86\u4e00\u4e2a\u65b0\u65b9\u5411\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cBrain control of humoral immune responses amenable to behavioural modulation\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Nature\u4e0a\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1aDOI:\u00a010.1038\/s41586-020-2235-7<\/p>\n<p>\u56fe6\u523a\u6fc0\u4e0e\u7535\u751f\u7406\u8bb0\u5f55\u8bc1\u5b9e\u813e\u795e\u7ecf\u6d3b\u52a8\u54cd\u5e94<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-204232 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72476-23.png\" alt=\"\" width=\"700\" height=\"666\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72476-23.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72476-23-300x285.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p><strong><b>Science<\/b><\/strong><strong><b>\uff1a<\/b><\/strong><strong><b>\u963f\u62c9\u4f2f\u7cd6\u57fa\u8f6c\u79fb\u9176\u4e0e\u6297\u7ed3\u6838\u836f\u7269\u4e59\u80fa\u4e01\u9187\u7684\u7ed3\u6784<\/b><\/strong><\/p>\n<p>\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u9976\u5b50\u548c\u9662\u58eb\u7814\u7a76\u56e2\u961f\u7b49\u9996\u6b21\u6210\u529f\u89e3\u6790\u4e86\u5206\u679d\u6746\u83cc\u5173\u952e\u7684\u963f\u62c9\u4f2f\u7cd6\u57fa\u8f6c\u79fb\u9176\u590d\u5408\u4f53EmbA-EmbB\u548cEmbC-EmbC\u7684\u201c\u836f\u9776-\u836f\u7269\u201d\u4e09\u7ef4\u7ed3\u6784\uff0c\u9996\u6b21\u63ed\u793a\u4e86\u4e00\u7ebf\u6297\u7ed3\u6838\u836f\u7269\u4e59\u80fa\u4e01\u9187\u4f5c\u7528\u4e8e\u8be5\u9776\u70b9\u7684\u7cbe\u786e\u5206\u5b50\u673a\u5236\u3002\u963f\u62c9\u4f2f\u7cd6\u57fa\u8f6c\u79fb\u9176EmbA\u3001EmbB\u548cEmbC\u53c2\u4e0e\u7ed3\u6838\u5206\u679d\u6746\u83cc\u7ec6\u80de\u58c1\u7684\u5408\u6210\uff0c\u88ab\u8ba4\u4e3a\u662f\u6297\u7ed3\u6838\u836f\u7269\u4e59\u80fa\u4e01\u9187\u7684\u9776\u70b9\u3002\u5229\u7528X\u5c04\u7ebf\u6676\u4f53\u5b66\u6280\u672f\u548c\u51b7\u51bb\u7535\u955c\u4e09\u7ef4\u91cd\u6784\u6280\u672f\u89e3\u6790\u4e86EmbA-EmbB\uff0cEmbC-EmbC\u5206\u522b\u4e0e\u5e95\u7269\uff08Ara2\uff0cDPA\uff09\u548c\u836f\u7269\u4e59\u80fa\u4e01\u9187\uff08EMB\uff09\u590d\u5408\u7269\u7684\u7ed3\u6784\u3002\u8fd9\u4e9b\u7ed3\u6784\u663e\u793a\u4e86\u4f9b\u4f53\u548c\u53d7\u4f53\u5e95\u7269\u5982\u4f55\u7ed3\u5408\u5728\u6d3b\u6027\u4f4d\u70b9\uff0c\u4ee5\u53ca\u4e59\u80fa\u4e01\u9187\u5982\u4f55\u901a\u8fc7\u4e0eEmbB\u548cEmbC\u5e95\u7269\u7ed3\u5408\u5728\u540c\u4e00\u4f4d\u70b9\u8fdb\u884c\u6291\u5236\u3002\u7814\u7a76\u5de5\u4f5c\u4e3a\u7406\u89e3\u963f\u62c9\u4f2f\u7cd6\u57fa\u8f6c\u79fb\u9176\u7684\u751f\u5316\u529f\u80fd\u548c\u6291\u5236\u4f5c\u7528\u4ee5\u53ca\u5f00\u53d1\u65b0\u7684\u6297\u7ed3\u6838\u836f\u7269\u63d0\u4f9b\u4e86\u7ed3\u6784\u57fa\u7840\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cStructures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Science\u4e0a\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5:\u00a010.1126\/science.aba9102<\/p>\n<p>\u56fe7\u00a0EmbA-EmbB-AcpM<sub>2<\/sub>\u548cEmbC<sub>2<\/sub>-AcpM<sub>2<\/sub>\u590d\u5408\u7269\u7684\u6d3b\u6027\u548c\u603b\u4f53\u7ed3\u6784<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-204233 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72477-18.png\" alt=\"\" width=\"700\" height=\"1023\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72477-18.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72477-18-205x300.png 205w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p><strong><b>Science\uff1a<\/b><\/strong><strong><b>Ca<\/b><\/strong><strong><sup><b>2+<\/b><\/sup><\/strong><strong><b>\u4f5c\u4e3a\u914d\u4f53\u7ed3\u5408\u7684\u8f85\u52a9\u56e0\u5b50<\/b><\/strong><strong><b>\u786e\u5b9a<\/b><\/strong><strong><b>\u9ed1\u7d20\u76ae\u8d28\u6fc0\u7d20\u53d7\u4f53<\/b><\/strong><strong><b>4<\/b><\/strong><strong><b>\u7ed3\u6784<\/b><\/strong><\/p>\n<p>\u4e0a\u6d77\u79d1\u6280\u5927\u5b66Raymond C. Stevens\u6559\u6388\u548c\u5bc6\u6b47\u6839\u5927\u5b66Roger D. Cone\u6559\u6388\u5728\u80a5\u80d6\u75c7\u836f\u7269\u9776\u70b9\u7814\u7a76\u4e0a\u53d6\u5f97\u91cd\u8981\u7a81\u7834\uff0c\u9996\u6b21\u89e3\u6790\u4eba\u6e90\u9ed1\u76ae\u8d28\u7d20\u53d7\u4f534\uff08Melanocortin-4 Receptor\uff0cMC4R\uff09\u4e0e\u73af\u5f62\u591a\u80bd\u914d\u4f53SHU9119\u590d\u5408\u72692.8\u57c3\u5206\u8fa8\u7387\u7684\u6676\u4f53\u7ed3\u6784\u3002MC4R\u7684\u7ed3\u6784\u6781\u5927\u5730\u4fc3\u8fdb\u4e86\u6211\u4eec\u5bf9\u9ed1\u76ae\u8d28\u7d20\u4fe1\u53f7\u673a\u5236\u7684\u7406\u89e3\uff0c\u6709\u52a9\u4e8e\u9488\u5bf9\u8fd9\u4e00\u53d7\u4f53\u8bbe\u8ba1\u6297\u80a5\u80d6\u75c7\u836f\u7269\uff0c\u5bf9\u4e8e\u6709\u80a5\u80d6\u75c7\u9057\u4f20\u503e\u5411\u7684\u4eba\u800c\u8a00\u8fd9\u4e9b\u4fe1\u606f\u5c24\u5176\u91cd\u8981\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cDetermination of the Melanocortin-4 Receptor Structure Identifies Ca2+ as a Cofactor for Ligand Binding\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Science\u4e0a\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1aDOI: 10.1126\/science.aaz8995<\/p>\n<p>\u56fe8\u00a0SHU9119-bound MC4R\u7684\u7ed3\u6784<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-204234 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72478-15.png\" alt=\"\" width=\"700\" height=\"468\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72478-15.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/06\/\u56fe\u72478-15-300x201.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p><strong><b>\u53e6\u5916\u8fd8\u67093\u7bc7\u751f\u7269\u533b\u5b66\u65b9\u9762\u7684<\/b><\/strong><strong><b>N<\/b><\/strong><strong><b>ature\u6587\u7ae0\uff0c\u4e0d\u518d\u505a\u5177\u4f53\u5206\u6790\u3002<\/b><\/strong><\/p>\n<p><strong><b>Structure of\u00a0M<\/b><\/strong><strong><sup><b>pro<\/b><\/sup><\/strong><strong><b>\u00a0from COVID-19 virus and discovery of its inhibitors<\/b><\/strong>\uff1a\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u9976\u5b50\u548c\u3001\u6768\u6d77\u6d9b\u56e2\u961f\u4e0e\u5408\u4f5c\u8005\u6210\u529f\u89e3\u6790\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u5173\u952e\u836f\u7269\u9776\u70b9\u2014\u2014\u4e3b\u86cb\u767d\u9176\uff08Mpro\uff09\u7684\u9ad8\u5206\u8fa8\u7387\u4e09\u7ef4\u7a7a\u95f4\u7ed3\u6784\u3002(DOI:\u00a010.1038\/s41586-020-2223-y)<\/p>\n<p><strong><b>Structure of the RNA-dependent RNA polymerase from COVID-19 Virus<\/b><\/strong>\uff1a\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u9976\u5b50\u548c\u9662\u58eb\u3001\u5a04\u667a\u52c7\u6559\u6388\u3001\u738b\u6743\u6559\u6388\u7b49\u6210\u529f\u89e3\u6790\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u201cRdRp\uff08RNA\u4f9d\u8d56\u7684RNA\u805a\u5408\u9176\uff09-nsp7-nsp8\u590d\u5408\u7269\u201d\u8fd1\u539f\u5b50\u5206\u8fa8\u7387\u4e09\u7ef4\u7a7a\u95f4\u7ed3\u6784\u7684\u7814\u7a76\u6210\u679c\u3002\u63ed\u793a\u4e86\u8be5\u75c5\u6bd2\u9057\u4f20\u7269\u8d28\u8f6c\u5f55\u590d\u5236\u673a\u5668\u6838\u5fc3\u201c\u5f15\u64ce\u201d\u7684\u7ed3\u6784\u7279\u5f81\uff0c\u4e3a\u5f00\u53d1\u9488\u5bf9\u65b0\u51a0\u80ba\u708e\u7684\u836f\u7269\u5960\u5b9a\u4e86\u91cd\u8981\u57fa\u7840\u3002\uff08DOI:\u00a010.1126\/science.abb7498\uff09<\/p>\n<p><strong><b>Structural basis of ligand recognition and self-activation of orphan GPR52<\/b><\/strong>\uff1a\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u5f90\u83f2\u8bfe\u9898\u7ec4\u4e0e\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u96f7\u9e23\u8bfe\u9898\u7ec4\u5408\u4f5c\u5728\u4eba\u4f53\u7ec6\u80de\u4fe1\u53f7\u8f6c\u5bfc\u7814\u7a76\u9886\u57df\u83b7\u91cd\u5927\u7a81\u7834\uff0c\u6210\u529f\u89e3\u6790\u4e86\u9996\u4e2a\u4eba\u6e90\u5b64\u513f\u53d7\u4f53\uff08GPR52\uff09\u4e09\u7ef4\u7cbe\u7ec6\u7ed3\u6784\u3002\u63ed\u793a\u4e86\u5b64\u513f\u53d7\u4f53\u5728\u65e0\u914d\u4f53\u3001\u6709\u914d\u4f53\u4ee5\u53ca\u4e0e\u4e0b\u6e38\u4fe1\u53f7\u8f6c\u5bfc\u5206\u5b50G\u86cb\u767d\u590d\u5408\u7269\u7ed3\u5408\u7684\u5404\u529f\u80fd\u72b6\u6001\u7684\u7ed3\u6784\u7279\u5f81\u3002\uff08DOI:\u00a010.1038\/s41586-020-2019-0\uff09<\/p>\n<p>\u6587\u4e2d\u6240\u8ff0\u72b9\u5982\u4e0d\u59a5\u4e4b\u5904\uff0c\u6b22\u8fce\u8bc4\u8bba\u533a\u7559\u8a00~<\/p>\n<p>\u672c\u6587\u7531Junas\u4f9b\u7a3f\u3002<\/p>\n<p>\u672c\u5185\u5bb9\u4e3a\u4f5c\u8005\u72ec\u7acb\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u6750\u6599\u4eba\u7f51\u7acb\u573a\u3002<\/p>\n<p>\u672a\u7ecf\u5141\u8bb8\u4e0d\u5f97\u8f6c\u8f7d\uff0c\u6388\u6743\u4e8b\u5b9c\u8bf7\u8054\u7cfbkefu@cailiaoren.com\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1: tougao@cailiaoren.com.<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenVIP\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u79d1\u5927\uff1a\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u662f\u4e00\u6240\u7531\u4e0a\u6d77\u5e02\u4eba\u6c11\u653f\u5e9c\u4e0e\u4e2d\u56fd\u79d1\u5b66\u9662\u5171\u540c\u4e3e\u529e\u3001\u5171\u540c\u5efa\u8bbe\uff0c\u7531\u4e0a\u6d77\u5e02\u4eba\u6c11\u653f\u5e9c\u4e3b\u7ba1\u7684\u5168\u65e5\u5236\u666e\u901a\u9ad8\u7b49\u5b66\u6821\uff1b\u662f\u6559\u80b2\u90e8\u548c\u4e0a\u6d77\u5e02\u5171\u5efa\u201c\u56fd\u5bb6\u6559\u80b2\u7efc\u5408\u6539\u9769\u8bd5\u9a8c\u533a&#8230;<\/p>\n","protected":false},"author":11454,"featured_media":204235,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1187],"tags":[],"class_list":["post-204226","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zhuanlan"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/204226"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/11454"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=204226"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/204226\/revisions"}],"predecessor-version":[{"id":204398,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/204226\/revisions\/204398"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/204235"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=204226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=204226"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=204226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}