{"id":201452,"date":"2020-06-27T06:18:25","date_gmt":"2020-06-26T22:18:25","guid":{"rendered":"\/\/m.iemloyee.com\/?p=201452"},"modified":"2020-06-26T22:18:35","modified_gmt":"2020-06-26T14:18:35","slug":"%e4%bb%8escience%e3%80%81nature%e7%b3%bb%e5%88%97%e7%9c%8b%e7%ba%b3%e7%b1%b3%e7%94%9f%e7%89%a9%e6%9d%90%e6%96%99%e7%9a%84%e5%85%b4%e8%b5%b7%ef%bc%81","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=201452","title":{"rendered":"\u4eceScience\u3001Nature\u7cfb\u5217\u770b\u7eb3\u7c73\u751f\u7269\u6750\u6599\u7684\u5174\u8d77\uff01"},"content":{"rendered":"

\u7eb3\u7c73\u751f\u7269\u6280\u672f\u662f\u6307\u7528\u4e8e\u7814\u7a76\u751f\u547d\u73b0\u8c61\u7684\u7eb3\u7c73\u6280\u672f\uff0c\u5b83\u662f\u7eb3\u7c73\u6280\u672f\u548c\u751f\u7269\u5b66\u7684\u7ed3\u5408\uff0c\u540c\u65f6\u4e5f\u662f\u4e00\u95e8\u6d89\u53ca\u7269\u7406\u5b66\u3001\u5316\u5b66\u3001\u91cf\u5b50\u5b66\u3001\u673a\u68b0\u5b66\u3001\u6750\u6599\u5b66\u3001\u7535\u5b50\u5b66\u3001\u8ba1\u7b97\u673a\u5b66\u3001\u751f\u7269\u5b66\u3001\u533b\u5b66\u7b49\u4f17\u591a\u9886\u57df\u7684\u7efc\u5408\u6027\u4ea4\u53c9\u5b66\u79d1\u3002\u662f\u56fd\u9645\u751f\u7269\u6280\u672f\u9886\u57df\u7684\u524d\u6cbf\u548c\u70ed\u70b9\u95ee\u9898\uff0c\u5728\u533b\u836f\u536b\u751f\u9886\u57df\u6709\u7740\u5e7f\u6cdb\u7684\u5e94\u7528\u548c\u660e\u786e\u7684\u4ea7\u4e1a\u5316\u524d\u666f\uff0c\u7279\u522b\u662f\u7eb3\u7c73\u836f\u7269\u8f7d\u4f53\u3001\u7eb3\u7c73\u751f\u7269\u4f20\u611f\u5668\u548c\u6210\u50cf\u6280\u672f\u4ee5\u53ca\u5fae\u578b\u667a\u80fd\u5316\u533b\u7597\u5668\u68b0\u7b49\uff0c\u4e3b\u8981\u5305\u542b\u4e24\u4e2a\u65b9\u9762\u5229\u7528\u65b0\u5174\u7684\u7eb3\u7c73\u6280\u672f\u89e3\u51b3\u548c\u751f\u7269\u5b66\u95ee\u9898\uff1b\u5229\u7528\u751f\u7269\u5927\u5206\u5b50\u5236\u9020\u5206\u5b50\u5668\u4ef6\uff0c\u6a21\u4eff\u548c\u5236\u9020\u7c7b\u4f3c\u751f\u7269\u5927\u5206\u5b50\u7684\u5206\u5b50\u673a\u5668\u3002<\/p>\n

\u4eca\u5929\u6211\u4eec\u4ece\u8fd1\u671fNature\u7cfb\u5217\u3001Science\u7b49\u9876\u520a\u770b\u4e00\u770b\u7814\u7a76\u8d8b\u52bf\uff1a<\/p>\n

Science\uff1a\u80ba\u6ce1\u6d3b\u6027\u7269\u8d28\u4eff\u751f\u7eb3\u7c73\u9897\u7c92\u589e\u5f3a\u62b5\u5fa1\u5f02\u578b\u6d41\u611f\u75c5\u6bd2\u611f\u67d3<\/b><\/strong><\/p>\n

\u76ee\u524d\u7684\u6d41\u611f\u75ab\u82d7\u5fc5\u987b\u6bcf\u5e74\u66f4\u65b0\uff0c\u4ee5\u5e94\u5bf9\u75c5\u6bd2\u8840\u51dd\u7d20(HA)\u548c\u795e\u7ecf\u6c28\u9178\u9176(NA)\u57fa\u56e0\u7684\u4e0d\u65ad\u7a81\u53d8\uff0c\u56e0\u4e3a\u75ab\u82d7\u4e3b\u8981\u8bf1\u5bfc\u9488\u5bf9\u8fd9\u4e9b\u8868\u9762\u6297\u539f\u7684\u4e2d\u548c\u6297\u4f53\u3002\u76f8\u6bd4\u75c5\u6bd2\u7684\u81ea\u7136\u611f\u67d3\u4ee5\u53ca\u51cf\u6bd2\u6d3b\u75ab\u82d7\u7b49\u590d\u5236\u6027\u75ab\u82d7\uff0c\u975e\u590d\u5236\u578b\u75ab\u82d7\u5f15\u8d77\u7684\u7c98\u819cT\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u8f83\u5dee\uff0c\u65e0\u6cd5\u8bf1\u5bfc\u8f83\u5f3a\u7684\u4fdd\u62a4\u6027\u514d\u75ab\u53cd\u5e94\u3002\u56e0\u6b64\u8feb\u5207\u9700\u8981\u5b89\u5168\u3001\u9ad8\u6548\u7684\u7c98\u819c\u4f50\u5242\u6765\u4fc3\u8fdb\u673a\u4f53\u4ea7\u751f\u4fdd\u62a4\u6027\u514d\u75ab\uff0c\u4ee5\u5e94\u5bf9\u4e0d\u540c\u7684\u6d41\u611f\u75c5\u6bd2\u611f\u67d3\u5e26\u6765\u7684\u5a01\u80c1\u3002\u5728\u6b64\uff0c\u590d\u65e6\u5927\u5b66\u9646\u8def\u3001\u59dc\u4e16\u52c3\u56e2\u961f\u8054\u5408\u54c8\u4f5b\u533b\u5b66\u9662\u9ebb\u7701\u603b\u533b\u9662Mei X. Wu\u526f\u6559\u6388\u5408\u6210\u4e86\u57fa\u4e8ecGAMP\u8bbe\u8ba1\u5236\u5907\u4e86\u4e00\u79cd\u80ba\u90e8\u4eff\u751f\u7eb3\u7c73\u9897\u7c92\uff08PS-GAMP\uff09\uff0ccGAMP\u662f\u5e72\u6270\u7d20\u57fa\u56e0\u8bf1\u5bfc\u5242STING(\u5e72\u6270\u7d20\u57fa\u56e0\u523a\u6fc0\u5242)\u7684\u6fc0\u52a8\u5242\u3002\u8be5\u4f50\u5242(PS-GAMP)\u901a\u8fc7\u6a21\u62df\u75c5\u6bd2\u611f\u67d3\u7684\u65e9\u671f\u9636\u6bb5\uff0c\u5728\u4e0d\u4f34\u6709\u8fc7\u5ea6\u708e\u75c7\u7684\u60c5\u51b5\u4e0b\uff0c\u6fc0\u6d3bAMs\u548cAECs\uff0c\u4fc3\u8fdb\u75ab\u82d7\u4ea7\u751f\u9ad8\u6548\u7684\u4f53\u6db2\u548cCD8+\u00a0T\u7ec6\u80de\u4fdd\u62a4\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u4ee5\u62b5\u6297\u591a\u79cd\u5f02\u578b\u6d41\u611f\u75c5\u6bd2\u7684\u653b\u51fb\u3002\u7814\u7a76\u7ed3\u679c\u63d0\u793aAECs\u5728\u4ea7\u751f\u5e7f\u6cdb\u7684\u4ea4\u53c9\u4fdd\u62a4\u4ee5\u62b5\u5fa1\u5404\u79cd\u6d41\u611f\u75c5\u6bd2\u65b9\u9762\u5177\u6709\u5341\u5206\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u8868\u660ePS-GAMP\u53ef\u80fd\u662f\u4e00\u79cd\u201c\u901a\u7528\u201d\u6d41\u611f\u75ab\u82d7\u7684\u6f5c\u5728\u7c98\u819c\u4f50\u5242\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cPulmonary surfactant\u2013biomimetic nanoparticles potentiate heterosubtypic influenza immunity\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Science\u4e0a\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/p>\n

DOI:\u00a010.1126\/science.aau0810<\/p>\n

\u56fe1\u00a0PS-GAMP\u4ecb\u5bfc\u7684\u4f50\u5242\u4f5c\u7528<\/p>\n

\"\"<\/p>\n

N<\/b><\/strong>at<\/b><\/strong>. Chem<\/b><\/strong>.\uff1a<\/b><\/strong>\u53ef\u7f16\u7a0b\u7684\u805a\u5408\u7269\u5e93\uff0c\u7528\u4e8e\u6784\u5efa\u5305\u542b\u903b\u8f91\u95e8\u7684<\/b><\/strong>\u523a\u6fc0<\/b><\/strong>\u54cd\u5e94\u7eb3\u7c73\u8f7d\u4f53<\/b><\/strong><\/p>\n

\u4f5c\u4e3a\u4e34\u5e8a\u6cbb\u7597\u7684\u4e00\u90e8\u5206\uff0c\u5305\u542b\u903b\u8f91\u95e8\u7684\u523a\u6fc0\u54cd\u5e94\u751f\u7269\u6750\u6599\u5728\u68c0\u6d4b\u548c\u54cd\u5e94\u75c5\u7406\u6807\u8bb0\u65b9\u9762\u5177\u6709\u5de8\u5927\u7684\u6f5c\u529b\u3002\u7136\u800c\uff0c\u4e00\u4e2a\u4e3b\u8981\u7684\u969c\u788d\u662f\u7f3a\u4e4f\u4e00\u4e2a\u901a\u7528\u7684\u7cfb\u7edf\uff0c\u53ef\u4ee5\u7528\u6765\u65b9\u4fbf\u5730\u7ec4\u88c5\u4e0d\u540c\u7684\u914d\u4f53\u54cd\u5e94\u5355\u5143\uff0c\u5f62\u6210\u53ef\u7f16\u7a0b\u7684\u7eb3\u7c73\u5668\u4ef6\uff0c\u7528\u4e8e\u5148\u8fdb\u7684\u751f\u7269\u8ba1\u7b97\u3002\u5728\u8fd9\u91cc\uff0c\u5357\u4eac\u5927\u5b66\u6731\u4fca\u6770\u6559\u6388\u3001\u897f\u5b89\u4ea4\u901a\u5927\u5b66\u5f90\u950b\u6559\u6388\u3001\u6e56\u5357\u5927\u5b66\u8c2d\u851a\u6cd3\u9662\u58eb\u8054\u5408\u5f00\u53d1\u4e86\u4e00\u4e2a\u53ef\u7f16\u7a0b\u7684\u805a\u5408\u7269\u5e93\uff0c\u901a\u8fc7\u5728\u5177\u6709\u76f8\u4f3c\u7ed3\u6784\u548c\u53cd\u5e94\u6d3b\u6027\u7684\u5efa\u7b51\u6a21\u5757\u4e2d\u5305\u542b\u54cd\u5e94\u5355\u5143\u3002\u5229\u7528\u8fd9\u4e9b\u805a\u5408\u7269\uff0c\u5f00\u53d1\u4e86\u4e00\u7cfb\u5217\u667a\u80fd\u7eb3\u7c73\u8f7d\u4f53\uff0c\u8fd9\u4e9b\u7eb3\u7c73\u8f7d\u4f53\u5177\u6709\u5c42\u6b21\u7ed3\u6784\uff0c\u5176\u4e2d\u5305\u542b\u4e0e\u81ea\u6211\u727a\u7272\u57fa\u5e8f\u76f8\u8fde\u7684\u903b\u8f91\u95e8\u3002\u4ee5\u75be\u75c5\u751f\u7269\u6807\u5fd7\u7269\u4e3a\u8f93\u5165\uff0c\u903b\u8f91\u88c5\u7f6e\u663e\u793a\u4e86\u591a\u79cd\u6cbb\u7597\u836f\u7269(\u5305\u62ec\u6fc0\u9176\u6291\u5236\u5242\u3001\u836f\u7269\u548c\u77ed\u5e72\u6270RNA)\u5728\u4f53\u5185\u548c\u4f53\u5916\u7684\u4f4d\u70b9\u7279\u5f02\u6027\u91ca\u653e\u3002\u8fd9\u79cd\u201c\u5373\u63d2\u5373\u7528\u201d\u7684\u5e73\u53f0\u53ef\u4ee5\u6269\u5c55\u5230\u667a\u80fd\u751f\u7269\u6750\u6599\u5de5\u7a0b\uff0c\u7528\u4e8e\u6cbb\u7597\u4f20\u9012\u3001\u7cbe\u51c6\u533b\u7597\u3001\u7ec4\u7ec7\u5de5\u7a0b\u548c\u5e72\u7ec6\u80de\u6cbb\u7597\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cA programmable polymer library that enables the construction of\u00a0stimuli-responsive nanocarriers containing logic gates\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Nat. Chem.\u4e0a\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/p>\n

DOI: 10.1038\/s41557-020-0426-3<\/p>\n

\u56fe2\u00a0\u5229\u7528\u9ad8\u5206\u5b50\u5e93\u8fdb\u884c\u903b\u8f91\u8ba1\u7b97\u548c\u5e8f\u8d2f\u91ca\u836f\u7684SNCs\u8bbe\u8ba1<\/p>\n

\"\"<\/p>\n

Nat. Mater.\uff1a<\/b><\/strong>\u7eb3\u7c73\u9897\u7c92\u8fdb\u5165\u5b9e\u4f53\u80bf\u7624<\/b><\/strong><\/p>\n

\u7eb3\u7c73\u9897\u7c92\u901a\u8fc7\u80bf\u7624\u8840\u7ba1\u5185\u7684\u5185\u76ae\u7ec6\u80de\u95f4\u9699(\u5185\u76ae\u7ec6\u80de\u95f4\u95f4\u9699)\u8fd0\u8f93\u7684\u6982\u5ff5\u662f\u764c\u75c7\u7eb3\u7c73\u533b\u5b66\u7684\u4e00\u4e2a\u4e2d\u5fc3\u8303\u5f0f\u3002\u53d1\u73b0\u8fd9\u4e9b\u95f4\u9699\u7684\u5927\u5c0f\u53ef\u8fbe2000\u7eb3\u7c73\u3002\u8fd9\u8bc1\u660e\u4e86\u7eb3\u7c73\u9897\u7c92\u7684\u53d1\u5c55\u53ef\u4ee5\u6cbb\u7597\u5b9e\u4f53\u80bf\u7624\uff0c\u56e0\u4e3a\u5b83\u4eec\u7684\u5927\u5c0f\u8db3\u591f\u5c0f\uff0c\u53ef\u4ee5\u6e17\u51fa\u5e76\u8fdb\u5165\u80bf\u7624\u5fae\u73af\u5883\u3002\u5728\u6b64\uff0c\u591a\u4f26\u591a\u5927\u5b66Warren C. W. Chan\u6559\u6388\u7b49\u4eba\u8bc1\u660e\u4e86\u8fd9\u4e9b\u5185\u76ae\u95f4\u9699\u5e76\u4e0d\u8d1f\u8d23\u7eb3\u7c73\u9897\u7c92\u8fdb\u5165\u5b9e\u4f53\u80bf\u7624\u7684\u8fd0\u8f93\u3002\u76f8\u53cd\uff0c\u7814\u7a76\u53d1\u73b0\u591a\u8fbe97%\u7684\u7eb3\u7c73\u9897\u7c92\u662f\u901a\u8fc7\u5185\u76ae\u7ec6\u80de\u7684\u6d3b\u6027\u8fc7\u7a0b\u8fdb\u5165\u80bf\u7624\u7684\u3002\u8fd9\u4e00\u7ed3\u679c\u6765\u81ea\u4e8e\u5bf9\u56db\u79cd\u4e0d\u540c\u7684\u5c0f\u9f20\u6a21\u578b\u3001\u4e09\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u4eba\u7c7b\u80bf\u7624\u3001\u6570\u5b66\u6a21\u62df\u548c\u5efa\u6a21\u4ee5\u53ca\u4e24\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u6210\u50cf\u6280\u672f\u7684\u5206\u6790\u3002\u8fd9\u4e9b\u7ed3\u679c\u6311\u6218\u4e86\u76ee\u524d\u5f00\u53d1\u764c\u75c7\u7eb3\u7c73\u836f\u7269\u7684\u57fa\u672c\u539f\u7406\uff0c\u5e76\u8868\u660e\u4e86\u89e3\u8fd9\u4e9b\u6d3b\u8dc3\u7684\u9014\u5f84\u5c06\u5f00\u542f\u589e\u5f3a\u80bf\u7624\u79ef\u7d2f\u7684\u7b56\u7565\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cThe entry of nanoparticles into solid tumours\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Nat. Mater.\u4e0a \u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/p>\n

DOI:\u00a010.1038\/s41563-019-0566-2<\/p>\n

\u56fe3\u00a0\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u901a\u8fc7\u6d3b\u6027\u7684\u8de8\u5185\u76ae\u9014\u5f84\u6e17\u51fa<\/p>\n

\"\"<\/p>\n

Nat<\/b><\/strong>.<\/b><\/strong>\u00a0Biomed<\/b><\/strong>.<\/b><\/strong>\u00a0En<\/b><\/strong>g.<\/b><\/strong>\uff1a<\/b><\/strong>\u53ef\u89c1\u5149\u548c\u8fd1\u7ea2\u5916I \/II\u7a97\u53e3\u7684\u591a\u5149\u8c31\u8367\u5149\u6210\u50cf<\/b><\/strong>\u7528\u4e8e<\/b><\/strong>\u809d\u810f\u80bf\u7624\u624b\u672f<\/b><\/strong><\/p>\n

\u7b2c\u4e8c\u8fd1\u7ea2\u5916\u6ce2\u957f\u7a97\u53e3(NIR-II, 1000-1700 nm)\u4f7f\u7ec4\u7ec7\u7684\u8367\u5149\u6210\u50cf\u5728\u6beb\u7c73\u6df1\u5ea6\u548c\u5fae\u7c73\u7ea7\u5206\u8fa8\u7387\u4e0b\u5177\u6709\u589e\u5f3a\u7684\u5bf9\u6bd4\u5ea6\u3002\u7136\u800c\uff0c\u4e34\u5e8a\u4e0a\u7f3a\u4e4f\u53ef\u884c\u7684NIR-II\u8bbe\u5907\uff0c\u963b\u788d\u4e86NIR-II\u6210\u50cf\u7684\u4e34\u5e8a\u8f6c\u8bd1\u3002\u5728\u8fd9\u91cc\uff0c\u4e2d\u79d1\u9662\u81ea\u52a8\u5316\u7814\u7a76\u6240\u7530\u6377\u7814\u7a76\u5458\u548c\u65af\u5766\u798f\u5927\u5b66Sanjiv Sam Gambhir,\u3001Zhen Cheng\u6559\u6388\u63cf\u8ff0\u4e86\u4e00\u79cd\u5149\u5b66\u6210\u50cf\u4eea\u5668\uff0c\u5b83\u96c6\u6210\u4e86\u4e00\u4e2a\u53ef\u89c1\u7684\u591a\u5149\u8c31\u6210\u50cf\u7cfb\u7edf\uff0c\u53ef\u4ee5\u68c0\u6d4bNIR-II\u548cNIR-I(700-900 nm)\u8367\u5149(\u4f7f\u7528\u5432\u54da\u83c1\u7eff\u67d3\u6599)\uff0c\u4ee5\u5e2e\u52a9\u5728\u8367\u5149\u5f15\u5bfc\u4e0b\u624b\u672f\u5207\u9664\u809d\u810f\u539f\u53d1\u548c\u8f6c\u79fb\u6027\u80bf\u7624\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u4e0eNIR-I\u6210\u50cf\u76f8\u6bd4\uff0c\u672f\u4e2dNIR-II\u6210\u50cf\u5177\u6709\u66f4\u9ad8\u7684\u80bf\u7624\u68c0\u6d4b\u7075\u654f\u5ea6\uff0c\u80bf\u7624\u4e0e\u6b63\u5e38\u809d\u7ec4\u7ec7\u4fe1\u53f7\u6bd4(5.33:1.45)\u66f4\u9ad8\uff0c\u80bf\u7624\u68c0\u51fa\u7387(56.41%:46.15%)\u589e\u5f3a\u3002\u7814\u7a76\u8fdb\u4e00\u6b65\u63a8\u6d4b\uff0c\u5c06NIR-I \/II\u5149\u8c31\u7a97\u4e0e\u5408\u9002\u7684\u8367\u5149\u63a2\u9488\u76f8\u7ed3\u5408\uff0c\u53ef\u80fd\u4f1a\u6539\u5584\u4e34\u5e8a\u4e0a\u7684\u5f71\u50cf\u5f15\u5bfc\u624b\u672f\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cFirst-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I\/II windows\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Nat. Biomed.\u00a0Eng.\u4e0a\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/p>\n

DOI:\u00a010.1038\/s41551-019-0494-0<\/p>\n

\u56fe4\u00a0\u53ef\u89c1\u5149\u548cNIR-\u0399\/ II\u4e34\u5e8a\u5e94\u7528\u591a\u5149\u8c31\u6210\u50cf\u4eea\u5668\u539f\u7406<\/p>\n

\"\"<\/p>\n

Nat. Nanotechnol.\uff1a<\/b><\/strong>\u53ef\u8f6c\u5316\u7684\u7eb3\u7c73\u80bd\u5728\u4f53\u5185\u6291\u5236HER2\u4fe1\u53f7\u5e76\u5bfc\u81f4\u764c\u7ec6\u80de\u6b7b\u4ea1<\/b><\/strong><\/p>\n

\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532 (HER2)\u572820%\u7684\u4e73\u817a\u764c\u4e2d\u8fc7\u8868\u8fbe\u3002HER2\u53d7\u4f53\u7684\u4e8c\u805a\u5bfc\u81f4\u4e0b\u6e38\u4fe1\u53f7\u7684\u6fc0\u6d3b\uff0c\u4f7f\u6076\u6027\u8868\u578b\u5f97\u4ee5\u589e\u6b96\u548c\u5b58\u6d3b\u3002\u7531\u4e8eHER2\u7684\u9ad8\u8868\u8fbe\u6c34\u5e73\uff0c\u76ee\u524dHER2+<\/sup>\u4e73\u817a\u764c\u7684\u6cbb\u7597\u9700\u8981\u8054\u5408\u6cbb\u7597\u3002\u5728\u8fd9\u91cc\uff0c\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821 Kit S. Lam\u6559\u6388\u56e2\u961f\u8054\u5408\u4e2d\u79d1\u9662\u738b\u78ca\u7814\u7a76\u5458\u8bbe\u8ba1\u4e86\u4e00\u79cd\u65e0\u6bd2\u7684\u53ef\u8f6c\u6362\u7684\u80bd\uff0c\u5b83\u53ef\u4ee5\u5728\u6c34\u73af\u5883\u4e0b\u81ea\u7ec4\u88c5\u6210\u80f6\u675f\uff0c\u4f46\u662f\uff0c\u5f53\u5b83\u4e0e\u764c\u7ec6\u80de\u4e0a\u7684HER2\u7ed3\u5408\u65f6\uff0c\u5c31\u4f1a\u8f6c\u5316\u6210\u7eb3\u7c73\u7ea4\u7ef4\uff0c\u7834\u574fHER2\u7684\u4e8c\u805a\u4f5c\u7528\uff0c\u5e76\u968f\u540e\u53d1\u751f\u4e0b\u6e38\u4fe1\u53f7\u4e8b\u4ef6\uff0c\u5bfc\u81f4\u764c\u7ec6\u80de\u51cb\u4ea1\u3002\u80bd\u6bb5\u7684\u76f8\u53d8\u4f7fHER2\u7279\u5f02\u6027\u9776\u5411\uff0c\u6291\u5236HER2\u4e8c\u805a\u6291\u5236\u7ec6\u80de\u6838\u5185\u589e\u6b96\u548c\u5b58\u6d3b\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u901a\u8fc7\u4f53\u5916\u53ca\u4f53\u5185\u5b9e\u9a8c\u9a8c\u8bc1\u4e86\u7eb3\u7c73\u9897\u7c92\u7684\u7ea4\u7ef4\u5316\u8f6c\u5316\u548c\u6700\u7ec8\u826f\u597d\u7684\u80bf\u7624\u6cbb\u7597\u6548\u679c\u3002\u8fd9\u79cd\u7ea4\u7ef4\u7ed3\u6784\u8f6c\u5316\u7684\u8d85\u5206\u5b50\u80bd\u4ee3\u8868\u4e86\u4e00\u7c7b\u53d7\u4f53\u4ecb\u5bfc\u9776\u5411\u764c\u75c7\u7eb3\u7c73\u65b0\u578b\u7597\u6cd5\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201c<\/b><\/strong>Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Nat. Nanotechnol.\u4e0a\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/p>\n

DOI:\u00a010.1038\/s41565-019-0626-4<\/p>\n

\u56fe5\u00a0\u53ef\u8f6c\u5316\u7684\u7eb3\u7c73\u80bd\u963b\u6b62HER2\u4fe1\u53f7\u4f20\u9012<\/p>\n

\"\"<\/p>\n

Nat. Nanotechnol<\/b><\/strong>.<\/b><\/strong>\uff1a<\/b><\/strong>\u53cc\u9776\u5411\u7eb3\u7c73\u75ab\u82d7\u5bf9\u6162\u6027\u4e59\u578b\u809d\u708e\u6709\u6cbb\u7597\u6027\u6297\u4f53\u5e94\u7b54<\/b><\/strong><\/p>\n

\u6162\u6027\u4e59\u578b\u809d\u708e\u662f\u7531\u957f\u671f\u611f\u67d3\u4e59\u578b\u809d\u708e\u75c5\u6bd2(HBV)\u5f15\u8d77\u7684\uff0c\u5b83\u4f1a\u5927\u5927\u589e\u52a0\u60a3\u809d\u75c5\u7684\u98ce\u9669\u3002\u5c3d\u7ba1\u5f00\u53d1\u4e86\u9884\u9632\u4e59\u809d\u75c5\u6bd2\u7684\u75ab\u82d7\uff0c\u4f46\u8bf1\u5bfc\u6709\u6548\u6297\u4f53\u53cd\u5e94\u7684\u6cbb\u7597\u6027\u75ab\u82d7\u4ecd\u7136\u96be\u4ee5\u627e\u5230\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u6731\u660e\u662d\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86\u57fa\u4e8e\u94c1\u86cb\u767d\u7eb3\u7c73\u9897\u7c92\u7684\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09preS1\u7eb3\u7c73\u75ab\u82d7\uff0c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u8bf1\u5bfc\u4ea7\u751f\u4e86\u9ad8\u6c34\u5e73\u3001\u9ad8\u4eb2\u548c\u529b\u3001\u6301\u4e45\u7684\u6297\u4f53\u5e94\u7b54\u548c\u514d\u75ab\u8bb0\u5fc6\uff0c\u4e0d\u4f46\u5177\u6709\u51fa\u8272\u7684\u9884\u9632\u4f5c\u7528\uff0c\u800c\u4e14\u5728\u6cbb\u7597\u6a21\u578b\u4e2d\u83b7\u5f97\u529f\u80fd\u6027\u6cbb\u6108\u548cHBsAg\u8840\u6e05\u5b66\u8f6c\u6362\uff0c\u5e76\u663e\u8457\u964d\u4f4eHBVcccDNA\u3002\u8be5\u7814\u7a76\u8fd8\u8fdb\u4e00\u6b65\u63ed\u793a\u4e86\u94c1\u86cb\u767d\u7eb3\u7c73\u9897\u7c92\u6297\u539f\u88ab\u6dcb\u5df4\u7ed3SIGNR1+<\/sup>\u6297\u539f\u5448\u9012\u7ec6\u80de\u4e3b\u52a8\u9776\u5411\u8bc6\u522b\u3001\u8f6c\u8fd0\u3001\u8bf1\u5bfcTfh\u548cB\u7ec6\u80de\u6d3b\u5316\u5e94\u7b54\u7684\u514d\u75ab\u5b66\u65b0\u673a\u5236\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cDual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Nat. Nanotechnol.\u4e0a\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/p>\n

DOI: 10.1038\/s41565-020-0648-y<\/p>\n

\u56fe6\u00a0\u94c1\u86cb\u767dNP\u75ab\u82d7\u7684\u5206\u5b50\u8bbe\u8ba1\u4e0e\u8868\u5f81<\/p>\n

\"\"<\/p>\n

Nat. Nanotechnol<\/b><\/strong>.<\/b><\/strong>\uff1a<\/b><\/strong>\u91d1\u7eb3\u7c73\u56e2\u7c07\u7528\u4e8e\u4f53\u5185\u75be\u75c5\u76d1\u6d4b<\/b><\/strong><\/p>\n

\u8d85\u5c0f\u91d1\u7eb3\u7c73\u56e2\u7c07(AuNCs)\u5df2\u6210\u4e3a\u4f53\u5185\u6210\u50cf\u7684\u7075\u654f\u63a2\u9488\uff0c\u56e0\u4e3a\u5b83\u4eec\u663e\u793a\u51fa\u5f02\u5e38\u7684\u80bf\u7624\u5806\u79ef\u548c\u9ad8\u6548\u7684\u80be\u810f\u6e05\u9664\u7279\u6027\u3002\u7136\u800c\uff0c\u5176\u5185\u5728\u7684\u50ac\u5316\u6d3b\u6027\uff0c\u53ef\u4ee5\u63d0\u9ad8\u68c0\u6d4b\u7075\u654f\u5ea6\uff0c\u8fd8\u6709\u5f85\u4e8e\u5728\u4f53\u5185\u68c0\u6d4b\u3002\u9ebb\u7701\u7406\u5de5\u5b66\u9662Sangeeta N. Bhatia\u6559\u6388\u548c\u4f26\u6566\u5e1d\u56fd\u7406\u5de5\u5b66\u9662Molly M. Stevens\u6559\u6388\u5408\u4f5c\u901a\u8fc7\u5229\u7528\u8fc7\u6c27\u5316\u7269\u9176\u6a21\u62df\u6d3b\u6027\u7684AuNCs\u548c\u7cbe\u786e\u7684\u7eb3\u7c73\u7ea7\u80be\u810f\u8fc7\u6ee4\uff0c\u8bbe\u8ba1\u4e86\u591a\u529f\u80fd\u86cb\u767d\u9176\u7eb3\u7c73\u4f20\u611f\u5668\uff0c\u53ef\u4ee5\u5bf9\u75be\u75c5\u5fae\u73af\u5883\u505a\u51fa\u53cd\u5e94\uff0c\u5728\u4e0d\u52301h\u7684\u65f6\u95f4\u5185\u4ea7\u751f\u75be\u75c5\u72b6\u6001\u7684\u76f4\u63a5\u6bd4\u8272\u6cd5\u5c3f\u6db2\u8bfb\u6570\u3002\u7814\u7a76\u76d1\u6d4b\u4e86\u6536\u96c6\u7684\u5927\u80a0\u764c\u5c0f\u9f20\u6a21\u578b\u5c3f\u4e2dAuNCs\u7684\u50ac\u5316\u6d3b\u6027\uff0c\u5728\u8be5\u6a21\u578b\u4e2d\uff0c\u80bf\u7624\u5c0f\u9f20\u5c0f\u9f20\u4e0e\u5065\u5eb7\u5c0f\u9f20\u76f8\u6bd4\uff0c\u6bd4\u8272\u4fe1\u53f7\u589e\u52a0\u4e8613\u500d\u3002\u5e76\u4e14\u6ce8\u5c04\u540e4\u5468\u5185\u901a\u8fc7\u809d\u3001\u80be\u6392\u6cc4\u5b8c\u5168\u6d88\u9664\u4e86\u7eb3\u7c73\u611f\u53d7\u5668\uff0c\u6ca1\u6709\u53d1\u73b0\u4efb\u4f55\u6bd2\u6027\u3002\u8fd9\u79cd\u6a21\u5757\u5316\u7684\u65b9\u6cd5\u5c06\u80fd\u591f\u901a\u8fc7\u5229\u7528\u5404\u79cd\u75be\u75c5\u7684\u7279\u5b9a\u9176\u4fe1\u53f7\u6765\u5b9e\u73b0\u5bf9\u5404\u79cd\u75be\u75c5\u7684\u5feb\u901f\u68c0\u6d4b\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u201cRenal clearablecatalytic gold nanoclusters for in vivo disease monitoring\u201d\u4e3a\u9898\u76ee\uff0c\u53d1\u8868\u5728Nat.\u00a0Nanotechnol. \u4e0a\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/p>\n

DOI: 10.1038\/s41565-019-0527-6<\/p>\n

\u56fe7\u00a0\u7eb3\u7c73\u50ac\u5316\u5242\u4fe1\u53f7\u653e\u5927\u4f20\u611f\u7cfb\u7edf\u7684\u8bbe\u8ba1<\/p>\n

\"\"<\/p>\n

\u6587\u4e2d\u5982\u6709\u4e0d\u59a5\u4e4b\u5904\uff0c\u6b22\u8fce\u8bc4\u8bba\u533a\u7559\u8a00~<\/p>\n

\u672c\u6587\u7531Junas\u4f9b\u7a3f\u3002<\/p>\n

\u672c\u5185\u5bb9\u4e3a\u4f5c\u8005\u72ec\u7acb\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u6750\u6599\u4eba\u7f51\u7acb\u573a\u3002<\/p>\n

\u672a\u7ecf\u5141\u8bb8\u4e0d\u5f97\u8f6c\u8f7d\uff0c\u6388\u6743\u4e8b\u5b9c\u8bf7\u8054\u7cfbkefu@cailiaoren.com\u3002<\/p>\n

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