{"id":200924,"date":"2020-05-05T06:25:49","date_gmt":"2020-05-04T22:25:49","guid":{"rendered":"\/\/m.iemloyee.com\/?p=200924"},"modified":"2020-05-04T22:26:30","modified_gmt":"2020-05-04T14:26:30","slug":"%e6%9c%80%e6%96%b0chem-rev-%e9%a1%b6%e5%88%8a%e7%bb%bc%e8%bf%b0%ef%bc%9a%e5%85%89%e8%81%9a%e5%90%88%e7%94%9f%e7%89%a9%e6%9d%90%e6%96%99%e5%92%8c%e5%9f%ba%e4%ba%8e%e5%85%89%e7%9a%843d%e6%89%93","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=200924","title":{"rendered":"\u6700\u65b0Chem. Rev.\u9876\u520a\u7efc\u8ff0\uff1a\u5149\u805a\u5408\u751f\u7269\u6750\u6599\u548c\u57fa\u4e8e\u5149\u76843D\u6253\u5370\u7b56\u7565\u5728\u751f\u7269\u533b\u5b66\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"

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\uff08B\uff090.5 mg\/mL CNT\/GelMA\u9884\u805a\u7269\u6eb6\u6db2\u7684\u9ad8\u5206\u8fa8\u7387TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08C\uff09\u9884\u805a\u7269\u6eb6\u6db2\u7684UV\u2212vis\u5438\u9644\u5149\u8c31\uff1b<\/p>\n

\uff08D\uff09CNT\/GelMA\u6c34\u51dd\u80f6\u7684\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\u56fe<\/b><\/strong>\u5341<\/b><\/strong>\u4e03<\/b><\/strong>\u3001<\/b><\/strong>\u5fae\u5f62\u9c7c\u56fe\u50cf\u76843D\u6253\u5370<\/b><\/strong>\"\"\uff08A\uff09\u5b9a\u4f4d\u4e8e\u5934\u90e8\u3001\u5c3e\u90e8\u548c\u8eab\u4f53\u76843D\u5fae\u9c7c\u7684\u4e0d\u540c\u7eb3\u7c73\u7c92\u5b50\u7684\u80fd\u91cf\u8272\u6563X\u5c04\u7ebf\uff1b<\/p>\n

\uff08B\uff093D\u6253\u5370\u7684\u8702\u80f6\u6eb6\u6db2\u5fae\u9c7c\u7684\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08C\uff09\u5fae\u9c7c\u5728\u78c1\u529b\u5f15\u5bfc\u4e0b\u4e0d\u540c\u65f6\u95f4\u7684\u56fe\u50cf\u3002<\/p>\n

\u56fe<\/b><\/strong>\u5341<\/b><\/strong>\u516b<\/b><\/strong>\u3001<\/b><\/strong>\u7f9f\u78f7\u7070\u77f3\uff08HA\uff09\u76843D\u6253\u5370<\/b><\/strong>\"\"\uff08A\uff09GelMA\u7f51\u7edc\u4e2d\u7f9f\u78f7\u7070\u77f3\uff08HA\uff09\u5f62\u6210\u673a\u7406\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09\u6253\u5370\u88c5\u7f6e\u539f\u7406\u56fe\uff1b<\/p>\n

\uff08C\uff093D\u6253\u5370\u6837\u54c1\u7684\u8868\u5f81\uff1b<\/p>\n

\uff08D\uff09\u7ed3\u6784\u4e2d\u7ec6\u80de\u7684\u5171\u7126\u56fe\u50cf\uff1b<\/p>\n

\uff08E\uff09\u82e5\u4e39\u660e\uff08\u7ea2\u8272\uff09\u704c\u6ce8\u7ba1\u7684\u8367\u5149\u56fe\u50cf<\/p>\n

\uff08F\uff093D\u6253\u5370\u76ae\u8d28\u9aa8\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe<\/b><\/strong>\u5341<\/b><\/strong>\u4e5d\u30013D\u6253\u5370\u809d\u810f\u89e3\u6bd2\u88c5\u7f6e<\/b><\/strong>\"\"\uff08A\uff09 \u805a\u4e8c\u4e59\u7094\u7eb3\u7c73\u7c92\u5b50\u5305\u88f9\u5728PEGDA\u4e2d\u76843D\u809d\u810f\u9a71\u52a8\u89e3\u6bd2\u88c5\u7f6e\u7684\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08B\uff09\u8fd9\u79cd\u89e3\u6bd2\u88c5\u7f6e\u7684SEM\u56fe\u50cf\uff1b<\/p>\n

\uff08C\uff09\u809d\u810f\u9a71\u52a8\u7684\u89e3\u6bd2\u88c5\u7f6e\u663e\u793a\u66f4\u9ad8\u7684\u4e2d\u548c\u6548\u7387\u3002<\/p>\n

\u56fe\u4e8c\u5341<\/b><\/strong>\u3001<\/b><\/strong>\u57fa\u4e8e\u5149\u76843D\u6253\u5370\u6a21\u5f0f\u7684\u5206\u7c7b<\/b><\/strong>\"\"\uff08A\uff09\u4ee5\u9010\u70b9\u6216\u9010\u884c\u65b9\u5f0f\u8fde\u7eed\u6c89\u79ef\u7684\u751f\u7269\u6750\u6599\uff1b<\/p>\n

\uff08B\uff09\u57fa\u4e8e\u6570\u5b57\u5149\u5904\u7406(DLP)\u7684\u5e73\u9762\u6784\u5efa\u6a21\u5f0f\u6295\u5f71\u5230\u751f\u7269\u6750\u6599\uff1b<\/p>\n

\uff08C\uff09\u57fa\u4e8eDLP\u7684\u6a21\u5f0f\u6295\u5f71\u7684\u4f53\u79ef\u6784\u5efa\u6295\u5f71\u5230\u751f\u7269\u6750\u6599\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/b><\/strong><\/p>\n

\u603b\u4e4b\uff0c\u591a\u5e74\u67653D\u6253\u5370\u6280\u672f\u5df2\u8fc5\u901f\u53d1\u5c55\u6210\u4e3a\u5728\u5236\u9020\u751f\u7269\u533b\u5b66\u5e94\u7528\u7684\u9ad8\u5ea6\u590d\u6742\u7ed3\u6784\u7684\u5148\u8fdb\u7cfb\u7edf\u3002\u8fd9\u79cd\u65b0\u578b\u7684\u5236\u9020\u65b9\u6cd5\u5df2\u7ecf\u7528\u4e8e\u5f00\u53d1\u65b0\u578b\u9aa8\u67b6\u3001\u7ec4\u7ec7\u548c\u5668\u5b98\u66ff\u4ee3\u54c1\u4ee5\u53ca\u533b\u5b66\u690d\u5165\u7269\uff0c\u4ece\u800c\u5b9e\u73b0\u5728\u4f20\u7edf\u751f\u7269\u5236\u9020\u4e2d\u65e0\u6cd5\u5b9e\u73b0\u7684\u7814\u7a76\u65b9\u6cd5\u3002\u540c\u65f6\u672c\u6587\u4e2d\u8fd8\u5f3a\u8c03\u4e86\u5149\u57fa3D\u6253\u5370\u673a\u6280\u672f\u5728\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u5373\u57fa\u4e8e\u5149\u76843D\u6253\u5370\u6280\u672f\u53ef\u4ee5\u5206\u4e3a\u4ece\u4e32\u884c\u5230\u5e73\u9762\u5230\u4f53\u79ef\u6784\u5efa\u7684\u5206\u5c42\u6253\u5370\u6a21\u5f0f\uff0c\u540c\u65f6\u5c06\u91cd\u70b9\u653e\u7f6e\u4e8e\u540e\u4e24\u79cd\u6a21\u5f0f\u4e0a\uff0c\u5176\u901a\u8fc7DLP\u7684\u6280\u672f\u5b9e\u73b0\uff0c\u8fd9\u4e3b\u8981\u662f\u7531\u4e8e\u5176\u4f18\u8d8a\u7684\u5fae\u7c73\u7ea7\u5206\u8fa8\u7387\u3001 \u4ee5\u79d2\u5230\u5206\u949f\u7684\u987a\u5e8f\u5feb\u901f\u5236\u9020\u901f\u5ea6\u548c\u53ef\u6269\u5c55\u6027\u3002\u6b64\u5916\uff0c\u8bc6\u522b\u548c\u7406\u89e3\u6bcf\u4e2a\u53c2\u6570\u7684\u5f71\u54cd\u5bf9\u4e8e\u6539\u8fdb\u7684\u4e0b\u4e00\u4ee33D\u6253\u5370\u6280\u672f\u7684\u8bbe\u8ba1\u548c\u5de5\u7a0b\u662f\u975e\u5e38\u6709\u4ef7\u503c\u7684\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a\u201c<\/b><\/strong>Photopolymerizable Biomaterials and Light-Based 3D Printing Strategies for Biomedical Applications<\/b><\/u><\/strong><\/a>\u201d(Chem. Rev.\uff0c2020\uff0cDOI: 10.1021\/acs.chemrev.9b00810)<\/b><\/strong><\/p>\n

\u672c\u6587\u7531CYM\u7f16\u8bd1\u4f9b\u7a3f\u3002<\/p>\n

\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

Shaochen Chen, PhD<\/b><\/strong><\/p>\n

Professor and Chair of NanoEngineering\u00a0Department<\/p>\n

University of California, San Diego<\/p>\n

Research:<\/b><\/strong>\u00a0Dr. Chen is a pioneer in 3D printing and bioprinting with over 200 peer-reviewed publications. He first initiated a scanningless 3D printing technique termed “micro-stereolithography (\u00b5SL)” for projection printing of biomaterials in 2006. \u00a0Building upon his \u00b5SL technique, he invented a dynamic optical stereolithography method (DOPsL) in 2012 (Advanced Materials, <\/i><\/em>2012). Compared to traditional nozzle-based 3D printing, DOPsL enables 3D printing that is 3,000 times faster in printing speed and 100 times finer in printing resolution (Nature Communications<\/i><\/em>, 2014). He has continued to advance this field by developing a microscale continuous optical bioprinting (\u00b5COB) method for the rapid 3D bioprinting of functional tissues models in mere seconds. Using human induced pluripotent stem cells, he successfully bioprinted functional liver tissues that enable disease modeling and drug screening (PNAS<\/i><\/em>, 2016). Furthermore, by integrating neuron stem cells within a 3D printed biomimetic scaffold, his team has succeeded in the repair of a severely damaged spinal cord in rats to result in significant functional recovery (Nature Medicine<\/i><\/em>, 2019). His ground-breaking work has been reported by The Washington Post<\/i><\/em>, The Wall Street Journal<\/i><\/em>, Forbes<\/i><\/em>, and Yahoo New<\/i><\/em>s.<\/p>\n

His pioneering work in micro and nanoscale 3D printing and bioprinting established the foundation for the emerging field of biofabrication for tissue engineering and regenerative medicine applications. He founded a startup company, Allegro 3D to commercialize his bioprinting techniques. It is providing transformative solutions to organ\/tissue repair and regeneration, accelerating drug toxicity and efficacy testing, and advancing human diseases modeling.<\/p>\n

Dr. Chen has received numerous awards, including the NSF CAREER award,<\/i><\/em>\u00a0ONR Young Investigator award, and NIH Edward Nagy New Investigator Award. In 2017, he received the Milton C. Shaw Manufacturing Research Medal from ASME for his seminal work in 3D printing, bioprinting, and nanomanufacturing. This is the highest award given by ASME to recognize original manufacturing research in the field. Dr. Chen is a Fellow of major societies, including the American Association for the Advancement of Science (AAAS), American Institute for Medical and Biological Engineering\u00a0(AIMBE), American Society of Mechanical Engineers (ASME), International Society for Optics and Photonics\u00a0(SPIE), and International Society for Nanomanufacturing (ISNM).<\/p>\n

Representative Publications \u00a0(out of 203 peer-reviewed papers)<\/p>\n

    \n
  1. <\/b>Lu and S. C. Chen*<\/b><\/strong>, \u201cMicro and Nano-fabrication of Biodegradable Polymers for Drug Delivery\u201d, Advanced Drug Delivery Reviews<\/i><\/em>, Vol. 56, pp. 1621-1633, 2004.<\/li>\n
  2. Lu, G. Mapili, G. Suhali, S. C. Chen*<\/b><\/strong>, K. Roy*, \u201cA Digital Micro-mirror Device-based System for the Microfabrication of Complex, Spatially Patterned Tissue Engineering Scaffolds\u201d, Journal of Biomedical Materials Research A, <\/i><\/em>Vol. 77A (2), pp 396-405, 2006.<\/li>\n
  3. P. \u00a0Zhang,X. Qu,\u00a0<\/sup>P. Soman,\u00a0<\/sup>K. C. Hribar,\u00a0<\/sup>J. W. Lee,\u00a0<\/sup>S. C. Chen<\/b><\/strong>*, and S. He, \u201cRapid Fabrication of Complex 3D Extracellular Microenvironments\u00a0by Dynamic Optical Projection Stereolithography\u201d, Advanced Materials<\/i><\/em>, Vol. 24 (no. 31), pp. 4266-4270, 2012.<\/li>\n
  4. Zhu, J. Li, Y. Leong,\u00a0I. Rozen, X. Qu, R. Dong, Z. Wu, W. Gao, P. H. Chung, J. Wang*,\u00a0and S. C. Chen<\/b><\/strong>*,<\/i>\u201c3D Printed Artificial Micro-Fish\u201d, Advanced Materials<\/i><\/em>, 27, pp. 4411\u20134417, 2015.<\/li>\n
  5. Ma, X. Qu, W. Zhu, Y.-S. Li, S. Yuan, H. Zhang, J. Liu, P. Wang, C. S. Lai, F. Zanella, G.-S. Feng, F. Sheikh, S. Chien*, S. C. Chen<\/b><\/strong>*, \u201cDeterministically Patterned Biomimetic Human iPSC-derived Hepatic Model via Rapid 3D Bioprinting\u201d, Proceedings of the National Academy of Sciences (PNAS)<\/i><\/em>, Vol. 113 (no. 8), pp. 2206-2211, 2016.<\/li>\n<\/ol>\n

    \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Highlighted in Nature Reviews Gastroenterology & Hepatology<\/i><\/em>, Feb 24, 2016.<\/strong><\/p>\n

      \n
    1. Zhu, X. Qu, J. Zhu, X. Ma, S. Patel, J. Liu, P. Wang, C. S. Lai, M. Gou, Y. Xu, K. Zhang, S. C. Chen*<\/b><\/strong>, \u201cDirect 3D bioprinting of prevascularized tissue constructs with complex microarchitecture\u201d, Biomaterials<\/i><\/em>, Vol. 124, pp. 106-115, 2017.<\/li>\n
    2. Zhu+<\/sup>, K. R. Tringale+<\/sup>, S. A. Woller, S. You, S. Johnson, H. Shen, J. Schimelman, M. Whitney, J. Steinauer, W. Xu, T. L. Yaksh, Q. T. Nguyen*, S. C. Chen*<\/b><\/strong>, \u201cRapid Continuous 3D Printing of Customizable Peripheral Nerve Guidance Conduits\u201d, Materials Today<\/i><\/em>, Vol. 21 (9), pp. 951-959, 2018.<\/li>\n
    3. Ma, C. Yu, P. Wang, W. Xu, X. Wan, C. S. E. Lai, J. Liu, A. Koroleva-Maharajh, S. C. Chen*<\/b><\/strong>, \u201cRapid 3D bioprinting of decellularized extracellular matrix with regionally varied mechanical properties and biomimetic microarchitecture\u201d, Biomaterials,<\/i><\/em>Vol. 185, pp. 310-321, 2018, DOI: 10.1016\/j.biomaterials.2018.09.026<\/li>\n
    4. Koffler+<\/sup>, W. Zhu+<\/sup>, X. Qu, O. Platoshyn, J. Dulin, J. Brock, L. Graham, P. Lu, J. Sakamoto, M. Marsala, S.C. Chen*<\/b><\/strong>, M. H. Tuszynski*, \u201cBiomimetic 3D-Printed Scaffolds for Spinal Cord Injury\u201d, Nature Medicine<\/i><\/em>, Vol. 25, pp. 263-269, 2019.<\/li>\n<\/ol>\n

      \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Highlighted in Nature Reviews Neuroscience<\/i><\/em>, Jan. 29, 2019, reported by NIH Director\u2019s Blog<\/i><\/em>\u00a0on\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 June 6, 2019.<\/h4>\n
        \n
      1. Tang, Q. Xie*, R. C. Gimple, Z. Zhong, T. Tam, J. Tian, R. L. Kidwell, \u00a0Q. Wu, B. C. Prager, Z. Qiu, A. Yu, Z. Zhu, P. Mesci, H. Jing, J. Schimelman, P. Wang, D. Lee, M. H. Lorenzini, \u00a0D. \u00a0Dixit, L. Zhao, S. Bhargava, T. E. Miller, X. Wan, J. Tang, B. Sun, B. F. Cravatt, A. R. Muotri, S.C. Chen<\/b><\/strong>*, J. N. Rich*, \u201cThree-dimensional bioprinting enables creation of tissue-informed glioblastoma microenvironments for modeling complex cellular interactions\u201d, Cell Research<\/i><\/em>, in press, 2020<\/li>\n
      2. Wangpraseurt*, S. You, F. Azam, G. Jacucci, O. Gaidarenko, M. Hildebrand, M. K\u00fchl, A. G. Smith, M.P. Davey, A. Smith, D. D. Deheyn, S. C. Chen<\/b><\/strong>*, S. Vignolini*,\u201c3D Printed Bionic Corals\u201d, Nature Communications<\/i><\/em>, Vol. 11, 1748 (1-8), 2020.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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