{"id":200673,"date":"2020-07-18T06:26:58","date_gmt":"2020-07-17T22:26:58","guid":{"rendered":"\/\/m.iemloyee.com\/?p=200673"},"modified":"2020-07-17T23:27:09","modified_gmt":"2020-07-17T15:27:09","slug":"%e5%8f%8d%e6%96%af%e6%89%98%e5%85%8b%e6%96%af%e5%8f%91%e5%85%89%e5%93%aa%e5%ae%b6%e5%bc%ba%ef%bc%9f%e4%b8%8a%e8%bd%ac%e6%8d%a2%e5%8f%91%e5%85%89%e6%9d%90%e6%96%99%e6%9c%80%e6%96%b0%e6%88%90%e6%9e%9c","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=200673","title":{"rendered":"\u53cd\u65af\u6258\u514b\u65af\u53d1\u5149\u54ea\u5bb6\u5f3a\uff1f\u4e0a\u8f6c\u6362\u53d1\u5149\u6750\u6599\u6700\u65b0\u6210\u679c\u901f\u9012"},"content":{"rendered":"

\u7a00\u571f\u63ba\u6742\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u53d1\u5149\u6750\u6599\uff08UCNP\uff09\u53ef\u4ee5\u5c06\u4f4e\u9891\u5149\u5b50\u8f6c\u5316\u4e3a\u9ad8\u9891\u5149\u5b50\uff0c\u901a\u5e38\u662f\u8fd1\u7ea2\u5916\u5149\u6fc0\u53d1\u3001\u53ef\u89c1\u5149\u53d1\u5c04\uff0c\u8fd9\u79cd\u72ec\u7279\u7684\u5149\u5b66\u6027\u8d28\u4f7f\u5176\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u5b66\u3001\u533b\u5b66\u5e94\u7528\u524d\u666f\u3002\u8fd1\u5e74\u6765\uff0cUCNP\u5df2\u7ecf\u5728\u751f\u7269\u6210\u50cf\u3001\u764c\u75c7\u6cbb\u7597\u3001\u4f20\u611f\u7b49\u9886\u57df\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\u3002\u672c\u6587\u603b\u7ed3\u4e86\u79d1\u7814\u754c\u5b66\u672f\u5927\u725b\u5728\u4e0a\u8f6c\u6362\u53d1\u5149\u6750\u6599\u9886\u57df\u7684\u6700\u65b0\u6210\u679c\uff0c\u5e0c\u671b\u5bf9\u4ece\u4e8b\u4e0a\u8f6c\u6362\u53d1\u5149\u6750\u6599\u76f8\u5173\u9886\u57df\u7684\u4f60\u6709\u6240\u542f\u53d1\u3002<\/p>\n

\u9648\u5b66\u5143\uff08\u4e2d\u56fd\u79d1\u5b66\u9662\u798f\u5efa\u7269\u8d28\u7ed3\u6784\u7814\u7a76\u6240\uff09<\/b><\/strong><\/p>\n

1. Angew. Chem. Int. Ed.\u6c27\u5316\u77f3\u58a8\u70ef\u4fee\u9970\u7684\u9567\u7cfb\u5143\u7d20\u7eb3\u7c73\u63a2\u9488\u7528\u4e8e\u80bf\u7624\u9776\u5411\u7684\u53ef\u89c1\/ NIR-II\u53d1\u5149\u6210\u50cf<\/b><\/strong><\/p>\n

\u5408\u6210\u5bf9\u751f\u7269\u6210\u50cf\u5177\u6709\u5206\u5b50\u8bc6\u522b\u80fd\u529b\u7684\u4eb2\u6c34\u6027\u9567\u7cfb\u5143\u7d20\u63ba\u6742\u7eb3\u7c73\u6676\u4f53\uff08Ln3+<\/sup>\u00a0-NCs\uff09\u4ecd\u7136\u662f\u6025\u9700\u89e3\u51b3\u7684\u95ee\u9898\u4e4b\u4e00\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u798f\u5efa\u7269\u8d28\u7ed3\u6784\u7814\u7a76\u6240\u9648\u5b66\u5143\u8bfe\u9898\u7ec4\u63d0\u51fa\u4e86\u4e00\u79cd\u6709\u6548\u7684\u7b56\u7565\u89e3\u51b3\u8be5\u95ee\u9898\uff0c\u5373\u901a\u8fc7\u5c06Ln3+<\/sup>\u00a0-NCs\u5c01\u88c5\u5728\u6c27\u5316\u77f3\u58a8\u70ef\uff08GO\uff09\u4e2d\u3002\u901a\u8fc7\u4f18\u5316GO\u5c3a\u5bf8\u548cNaYF4<\/sub>\uff1aYb\uff0cEr @ NaYF4<\/sub>\u7684\u6838-\u58f3\u7ed3\u6784\u6765\u5236\u5907\u5355\u5206\u6563NCs @ GO\uff0c\u4ece\u800c\u7ed3\u5408\u4e86\u7eb3\u7c73\u6676\u5f3a\u70c8\u7684\u53ef\u89c1\/\u8fd1\u7ea2\u5916II\uff08NIR-II\uff09\u53d1\u5149\u4ee5\u53caGO\u72ec\u7279\u7684\u8868\u9762\u6027\u8d28\u548c\u751f\u7269\u533b\u5b66\u529f\u80fd\u3002\u8be5\u7eb3\u7c73\u7ed3\u6784\u4e0d\u4ec5\u5177\u6709\u5e7f\u6cdb\u7684\u6eb6\u5242\u5206\u6563\u6027\u3001\u6709\u6548\u7684\u7ec6\u80de\u5438\u6536\u80fd\u529b\u548c\u51fa\u8272\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u800c\u4e14\u8fd8\u53ef\u4ee5\u4f7f\u7528\u5404\u79cd\u8bd5\u5242\uff08\u4f8b\u5982DNA\u3001\u86cb\u767d\u8d28\u6216\u7eb3\u7c73\u9897\u7c92\uff09\u8fdb\u884c\u8fdb\u4e00\u6b65\u4fee\u9970\uff0c\u800c\u65e0\u9700\u7e41\u7410\u7684\u7a0b\u5e8f\u3002\u5728\u8be5\u5b9e\u9a8c\u4e2d\u8bc1\u660eNCs @ GO\u53ef\u4ee5\u5b9e\u73b0\u540c\u65f6\u7684\u7ec6\u80de\u5185\u8ddf\u8e2a\u548cmicroRNA-21\u53ef\u89c6\u5316\uff0c\u4ee5\u53ca\u57281525 nm\u5904\u5b9e\u73b0\u4f53\u5185\u9776\u5411\u80bf\u7624\u7684NIR-II\u6210\u50cf\u3002\u8be5\u65b9\u6cd5\u4e3a\u5408\u6210\u5177\u6709\u53ef\u5b9a\u5236\u7684\u8868\u9762\u5c5e\u6027\u548c\u751f\u7269\u533b\u5b66\u529f\u80fd\u7684\u7eb3\u7c73\u63a2\u9488\u63d0\u4f9b\u4e00\u79cd\u65b0\u7684\u89c1\u89e3\uff0c\u8fd9\u6210\u50cf\u548c\u6cbb\u7597\u5e94\u7528\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002[1]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cGraphene-Oxide-Modified Lanthanide Nanoprobes for Tumor-Targeted Visible\/NIR-II Luminescence Imaging\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728Angew. Chem. Int. Ed.\u3002<\/p>\n

\u56fe\u4e00\uff1a\u7eb3\u7c73\u6676\u7684\u5408\u6210\u793a\u610f\u56fe\u53ca\u8868\u5f81\u56fe<\/b><\/strong><\/p>\n

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2. Adv. Sci. \u8fd1\u7ea2\u5916\u53cc\u6fc0\u53d1\u4e0a\u8f6c\u6362\u6750\u6599\u7528\u4e8e\u80de\u5185\u6bd4\u4f8b\u578b\u68c0\u6d4b<\/b><\/strong><\/p>\n

\u7ec6\u80de\u5185\u68c0\u6d4b\u5bf9\u4e8e\u751f\u7269\u5b66\u7814\u7a76\u548c\u4e34\u5e8a\u8bca\u65ad\u662f\u975e\u5e38\u9700\u8981\u7684\uff0c\u4f46\u662f\u53d1\u5c55\u5177\u6709\u975e\u4fb5\u5165\u6027\u3001\u654f\u611f\u6027\u548c\u51c6\u786e\u6027\u7684\u5b9a\u91cf\u5206\u6790\u4ecd\u7136\u662f\u9700\u89e3\u51b3\u7684\u95ee\u9898\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u798f\u5efa\u7269\u8d28\u7ed3\u6784\u7814\u7a76\u6240\u9648\u5b66\u5143\u8bfe\u9898\u7ec4\u63d0\u51fa\u4e86\u901a\u8fc7\u67d3\u6599\u654f\u5316\u4e0a\u8f6c\u6362\u63a2\u9488\u7684\u8bbe\u8ba1\u548c\u4f7f\u7528\u4e13\u7528\u7684\u8fd1\u7ea2\u5916\u53cc\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u8fdb\u884c\u6bd4\u7387\u5f0f\u7ec6\u80de\u5185\u68c0\u6d4b\u7684\u8fd1\u7ea2\u5916\uff08NIR\uff09\u53cc\u6fc0\u53d1\u7b56\u7565\u3002NIR\u67d3\u6599IR808\u662f\u7ec6\u80de\u5185\u5206\u6790\u7269\u6b21\u6c2f\u9178\u76d0\u7684\u8bc6\u522b\u5242\uff0c\u5e76\u88ab\u4f5c\u4e3a\u80fd\u91cf\u4f9b\u4f53\uff1bYb\uff0cEr\u63ba\u6742\u7684NaGdF4<\/sub>\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\u88ab\u7528\u4f5c\u7eb3\u7c73\u63a2\u9488\u4e2d\u7684\u80fd\u91cf\u53d7\u4f53\u3002\u6709\u6548\u7684\u4f9d\u8d56\u4e8e\u5206\u6790\u7269\u7684\u80fd\u91cf\u8f6c\u79fb\u548c\u4f4e\u80cc\u666f\u53d1\u5149\u4f7f\u7eb3\u7c73\u63a2\u9488\u5177\u6709\u8d85\u9ad8\u7684\u7075\u654f\u5ea6\u3002\u901a\u8fc7\u4ee5980 nm\u6fc0\u53d1\u7684\u975e\u5206\u6790\u7269\u4f9d\u8d56\u6027\u4e0a\u8f6c\u6362\u53d1\u5149\uff08UCL\uff09\u4f5c\u4e3a\u81ea\u6821\u51c6\u4fe1\u53f7\uff0c\u51cf\u8f7b\u6765\u81ea\u73af\u5883\u6ce2\u52a8\u7684\u5e72\u6270\u3002\u5b9e\u9a8c\u8bc1\u660e\u4e86\u53cc808\/980 nm\u6fc0\u53d1\u6bd4\u4f8bUCL\u53ef\u5b9a\u91cf\u6d4b\u5b9a\u7ec6\u80de\u5185\u6b21\u6c2f\u9178\u76d0\u7684\u6c34\u5e73\uff0c\u786e\u5b9a\u4e86\u5728\u6ca1\u6709\u5916\u6e90\u523a\u6fc0\u7684\u60c5\u51b5\u4e0b\u5728\u6d3b\u7684MCF-7\u7ec6\u80de\u4e2d\u4ec5\u5177\u6709\u7eb3\u6469\u5c14\u6d53\u5ea6\u7684\u6b21\u6c2f\u9178\u76d0\u3002\u8fd9\u79cd\u57fa\u4e8e\u67d3\u6599\u654f\u5316UCL\u63a2\u9488\u7684NIR\u53cc\u6fc0\u53d1\u6bd4\u7387\u6d4b\u91cf\u7b56\u7565\u53ef\u4ee5\u6269\u5c55\u5230\u5176\u4ed6\u68c0\u6d4b\u4e2d\uff0c\u901a\u8fc7\u5b9a\u5236\u53cd\u5e94\u6027NIR\u67d3\u6599\u6765\u68c0\u6d4b\u5404\u79cd\u7ec6\u80de\u5185\u5206\u6790\u7269\uff0c\u8fd9\u4e3a\u63a2\u6d4b\u6d3b\u7ec6\u80de\u4e2d\u7684\u751f\u5316\u8fc7\u7a0b\u548c\u8bca\u65ad\u75be\u75c5\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u5de5\u5177\u3002[2]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cA Strategy of NIR Dual-Excitation Upconversion\u00a0for Ratiometric Intracellular Detection\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728Adv. Sci.\u3002<\/p>\n

\u56fe\u4e8c\uff1aNIR\u67d3\u6599\u654f\u5316\u4e0a\u8f6c\u6362\u7eb3\u7c73\u63a2\u9488\u4e2d\u4f9d\u8d56\u5206\u6790\u7269\u7684\u80fd\u91cf\u8f6c\u79fb\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

3. Angew. Chem. Int. Ed. \u4f7f\u7528\u65f6\u95f4\u5206\u8fa8\u7684\u53d1\u5149\u9567\u7cfb\u5143\u7d20\u7eb3\u7c73\u63a2\u9488\u76f4\u63a5\u68c0\u6d4b\u5168\u8840\u4e2d\u7684\u5faa\u73af\u80bf\u7624\u7ec6\u80de<\/b><\/strong><\/p>\n

\u5faa\u73af\u80bf\u7624\u7ec6\u80de\uff08CTC\uff09\u7684\u68c0\u6d4b\u5bf9\u4e8e\u65e9\u671f\u764c\u75c7\u8bca\u65ad\u548c\u764c\u75c7\u8f6c\u79fb\u8bc4\u4f30\u81f3\u5173\u91cd\u8981\u3002\u7136\u800c\uff0c\u7531\u4e8e\u8840\u6db2\u4e2dCTC\u7684\u6d53\u5ea6\u5f88\u4f4e\uff0c\u7075\u654f\u68c0\u6d4bCTC\u4ecd\u7136\u5177\u6709\u6311\u6218\u6027\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u798f\u5efa\u7269\u8d28\u7ed3\u6784\u7814\u7a76\u6240\u9648\u5b66\u5143\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4f7f\u7528\u53d1\u5149\u9567\u7cfb\u5143\u7d20\u7eb3\u7c73\u63a2\u9488\u6784\u5efa\u4e00\u79cd\u8d85\u7075\u654f\u5e73\u53f0\u7528\u4e8e\u76f4\u63a5\u68c0\u6d4bCTC\u3002\u8be5\u7eb3\u7c73\u63a2\u9488\u88ab\u8bbe\u8ba1\u7528\u6765\u8bc6\u522b\u764c\u7ec6\u80de\u4e0a\u76ae\u7ec6\u80de\u7684\u7c98\u9644\u5206\u5b50\uff0c\u4ece\u800c\u5141\u8bb8\u901a\u8fc7\u589e\u52a0\u6eb6\u89e3\u65f6\u95f4\u7684\u5206\u8fa8\u5149\u81f4\u53d1\u5149\uff08TRPL\uff09\u4fe1\u53f7\u653e\u5927\uff0c\u5e76\u6d88\u9664\u4e86\u77ed\u6682\u7684\u81ea\u53d1\u8367\u5149\u5e72\u6270\u3002\u8be5\u65b9\u6cd5\u53ef\u4ee5\u76f4\u63a5\u68c0\u6d4b\u8840\u6db2\u4e2d\u7684\u4e73\u817a\u764c\u7ec6\u80de\uff0c\u68c0\u6d4b\u9650\u4ec5\u4e3a96\u5b54\u677f\u76841\u4e2a\u7ec6\u80de\/\u5b54\u3002\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u53ef\u4ee5\u68c0\u6d4b\u5230\u8840\u6db2\u4e2d\u7684CTC\uff08\u226510 cell mL-1<\/sup>\uff09\uff0c\u68c0\u51fa\u7387\u4e3a93.9\uff05\uff0814\/15\u60a3\u8005\uff09\u3002\u8fd9\u79cd\u5177\u6709\u51fa\u8272\u5b9e\u7528\u6027\u7684\u8d85\u7075\u654f\u68c0\u6d4b\u5e73\u53f0\u53ef\u80fd\u4e3a\u65e9\u671f\u764c\u75c7\u8bca\u65ad\u548c\u9884\u540e\u8bc4\u4f30\u63d0\u4f9b\u6709\u6548\u7684\u7b56\u7565\u3002[3]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cDirect Detection of Circulating Tumor Cells in Whole Blood Using\u00a0Time-Resolved Luminescent Lanthanide Nanoprobes\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728Angew. Chem. Int. Ed.\u3002<\/p>\n

\u56fe\u4e09\uff1aNaEuF<\/b><\/strong>4<\/b><\/sub><\/strong>\u7eb3\u7c73\u7c92\u5b50\u529f\u80fd\u5316\u548cCTC\u6d4b\u5b9a\u8fc7\u7a0b\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u674e\u4e50\u4e50\uff08\u56fd\u5bb6\u7eb3\u7c73<\/b><\/strong>\u79d1\u5b66<\/b><\/strong>\u4e2d\u5fc3\uff09<\/b><\/strong><\/p>\n

4. J. Am. Chem. Soc. \u4e0a\u8f6c\u6362\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u7684\u8fd1\u7ea2\u5916\u5149\u89e6\u53d1\u7ec4\u5408\u4f4e\u6c27\u80bf\u7624\u5149\u52a8\u529b\u5b66\/\u5316\u5b66\/\u514d\u75ab\u6cbb\u7597\u5de5\u7a0b<\/b><\/strong><\/p>\n

\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\uff08MOF\uff09\u4f5c\u4e3a\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u7684\u7eb3\u7c73\u5149\u654f\u5242\u5177\u6709\u5de8\u5927\u7684\u6f5c\u529b\u3002\u4f46\u662f\uff0cPDT\u4e2d\u6b64\u7c7bMOF\u7684\u4f7f\u7528\u53d7\u5230\u77ed\u6ce2\u957f\u5149\u7684\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\u6d45\u548c\u6c27\u4f9d\u8d56\u6027\u673a\u5236\u7684\u9650\u5236\uff0c\u8be5\u673a\u5236\u4f7f\u5176\u4e0d\u8db3\u4ee5\u6cbb\u7597\u7f3a\u6c27\u6027\u80bf\u7624\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u5c40\u9650\u6027\uff0c\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u8d75\u5b87\u4eae\u548c\u674e\u4e50\u4e50\u8bfe\u9898\u7ec4\u5408\u7406\u8bbe\u8ba1\u4e86\u6838-\u58f3\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92@\u535f\u5549MOF\uff08UCS\uff09\u7528\u4e8e\u6297\u7f3a\u6c27\u80bf\u7624\u7684\u8054\u5408\u6cbb\u7597\u3002\u901a\u8fc7UCNPs\u8868\u9762\u5de5\u7a0b\u548c\u968f\u540e\u7684\u79cd\u5b50\u4ecb\u5bfc\u7684\u751f\u957f\u7b56\u7565\uff0c\u9ad8\u4ea7\u91cf\u5730\u5408\u6210\u4e86UCS\u3002\u5f02\u8d28\u7ed3\u6784\u5141\u8bb8\u4eceUCNP\u6838\u5fc3\u5230MOF\u5916\u58f3\u7684\u6709\u6548\u80fd\u91cf\u8f6c\u79fb\uff0c\u8fd9\u4f7f\u8fd1\u7ea2\u5916\uff08NIR\uff09\u5149\u89e6\u53d1\u7684\u7ec6\u80de\u6bd2\u6027\u6d3b\u6027\u6c27\u7269\u79cd\u4ea7\u751f\u3002\u5c06\u4f4e\u6c27\u6fc0\u6d3b\u7684\u66ff\u62c9\u624e\u660e\uff08TPZ\uff09\u5c01\u88c5\u5728\u5f02\u8d28\u7ed3\u6784\u7684MOF\u58f3\u7684\u7eb3\u7c73\u5b54\u4e2d\uff0c\u4ee5\u4ea7\u751f\u6700\u7ec8\u7684\u6784\u5efa\u4f53TPZ \/ UCS\u3002\u5b9e\u9a8c\u8bc1\u660e\u4e86TPZ \/ UCSs\u4ee3\u8868\u4e86\u4e00\u79cd\u6709\u524d\u9014\u7684\u7cfb\u7edf\uff0c\u53ef\u901a\u8fc7NIR\u5149\u8bf1\u5bfc\u7684PDT\u548c\u7f3a\u6c27\u6fc0\u6d3b\u7684\u5316\u5b66\u7597\u6cd5\u76f8\u7ed3\u5408\uff0c\u5728\u4f53\u5185\u5916\u5b9e\u73b0\u764c\u75c7\u6cbb\u7597\u3002\u8be5\u7eb3\u7c73\u5e73\u53f0\u4e0e\u6297\u7f16\u7a0b\u6b7b\u4ea1\u914d\u4f531\uff08a-PD-L1\uff09\u6cbb\u7597\u7684\u6574\u5408\u901a\u8fc7\u4ea7\u751f\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u7684\u7279\u5f02\u6027\u80bf\u7624\u6d78\u6da6\uff0c\u4fc3\u8fdb\u4e86\u653e\u7597\u8fdc\u7aef\u6548\u5e94\uff0c\u4ece\u800c\u5b8c\u5168\u6291\u5236\u4e86\u672a\u7ecf\u6cbb\u7597\u7684\u8fdc\u5904\u80bf\u7624\u7684\u751f\u957f\u3002\u8fd9\u9879\u5de5\u4f5c\u7a81\u51fa\u4e86\u5c06NIR\u5149\u89e6\u53d1\u7684PDT\u548c\u7f3a\u6c27\u6fc0\u6d3b\u7684\u5316\u5b66\u7597\u6cd5\u4e0e\u514d\u75ab\u7597\u6cd5\u76f8\u7ed3\u5408\u7684\u5f3a\u5927\u7eb3\u7c73\u5e73\u53f0\uff0c\u4ee5\u514b\u670d\u5f53\u524d\u80bf\u7624\u6cbb\u7597\u7684\u5c40\u9650\u6027\u3002[4]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cEngineering of Upconverted Metal\u2212Organic Frameworks for Near-Infrared Light-Triggered Combinational Photodynamic\/Chemo-\/Immunotherapy against Hypoxic Tumors\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728J. Am. Chem. Soc.\u3002<\/p>\n

\u56fe\u56db\uff1aTPZ \/ UCSs\u7684\u7ed3\u6784\u53ca\u5176\u8fd1\u7ea2\u5916\u5149\u89e6\u53d1\u7684PDT\u548c\u7f3a\u6c27\u6fc0\u6d3b\u7684\u5316\u5b66\u7597\u6cd5\u4e0e\u514d\u75ab\u7597\u6cd5\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

5. Angew. Chem. Int. Ed. Nd<\/b><\/strong>3+<\/b><\/sup><\/strong>\u654f\u5316\u7684\u4e0a\u8f6c\u6362\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u7528\u4e8e\u7ebf\u7c92\u4f53\u9776\u5411\u7684\u653e\u5927\u5149\u52a8\u529b\u7597\u6cd5<\/b><\/strong><\/p>\n

\u9567\u7cfb\u5143\u7d20\u63ba\u6742\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u5728NIR\u5149\u6fc0\u53d1\u4e0b\u53ef\u4ee5\u53d1\u51fa\u9ad8\u80fdUV\u6216\u53ef\u89c1\u5149\uff0c\u8fd9\u5bf9\u4e8eNIR\u4ecb\u5bfc\u7684\u5149\u8c03\u8282\u7684\u751f\u7269\u4f20\u611f\u3001\u795e\u7ecf\u6d3b\u52a8\u548c\u751f\u7269\u533b\u5b66\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u674e\u4e50\u4e50\u548c\u8d75\u5b87\u4eae\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u57fa\u4e8e\u91d1\u5c5e\u6709\u673a\u6846\u67b6\uff08MOF\uff09\u548c\u4e0a\u8f6c\u6362\u5149\u5316\u5b66\u4e0e\u7ec6\u80de\u5668\u9776\u5411\u7b56\u7565\u76f8\u7ed3\u5408\u7684\u7ebf\u7c92\u4f53\u7279\u5f02\u6027808 nm NIR\u5149\u6fc0\u6d3b\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u7cfb\u7edf\u7684\u8bbe\u8ba1\u548c\u5408\u6210\u3002\u8be5\u7cfb\u7edf\u662f\u901a\u8fc7\u5728Nd3+<\/sup>\u654f\u5316\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\u4e0a\u751f\u957f\u535f\u5549MOF\u4ece\u800c\u83b7\u5f97\u5177\u6709\u8fdb\u4e00\u6b65\u4e0d\u5bf9\u79f0\u529f\u80fd\u5316MOF\u57df\u8868\u9762\u7684Janus\u7eb3\u7c73\u7ed3\u6784\u3002PDT\u7eb3\u7c73\u5e73\u53f0\u5141\u8bb8\u4f7f\u7528808 nm NIR\u5149\u8fdb\u884c\u5149\u654f\u5316\uff0c\u53ef\u4ee5\u6709\u6548\u907f\u514d\u6fc0\u5149\u8f90\u7167\u5f15\u8d77\u7684\u8fc7\u70ed\u6548\u5e94\u3002\u7ebf\u7c92\u4f53\u9776\u5411\u53ef\u901a\u8fc7\u7ebf\u7c92\u4f53\u819c\u53bb\u6781\u5316\u548c\u5185\u5728\u51cb\u4ea1\u9014\u5f84\u7684\u542f\u52a8\u6765\u6269\u5927PDT\u7684\u529f\u6548\u3002\u8fd9\u9879\u5de5\u4f5c\u9610\u660e\u4e86MOF\u7684\u6df7\u5408\u5de5\u7a0b\u6280\u672f\u4ee5\u514b\u670d\u5176\u5f53\u524d\u5bf9PDT\u7684\u9650\u5236\u3002[5]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cNd3+<\/sup>-Sensitized Upconversion Metal-Organic Frameworks for\u00a0Mitochondria-Targeted Amplified Photodynamic Therapy\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728Angew. Chem. Int. Ed.\u3002<\/p>\n

\u56fe\u4e94\uff1aNIR\u5149\u6fc0\u6d3b\u7684\u3001\u7ebf\u7c92\u4f53\u9776\u5411\u7684\u4e0a\u8f6c\u6362MOF\u7528\u4e8e\u653e\u5927PDT\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

6. Chem. Sci.\u5149\u81f4\u53d8\u8272\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7ed3\u6784\uff1a\u53ef\u6fc0\u6d3b\u7684\u751f\u7269\u6210\u50cf\u548c\u53cc\u8fd1\u7ea2\u5916\u5149\u7f16\u7a0b\u5355\u7ebf\u6001\u6c27\u751f\u6210<\/b><\/strong><\/p>\n

\u751f\u7269\u5b66\u7814\u7a76\u548c\u7cbe\u5bc6\u533b\u5b66\u5bf9\u5355\u7ebf\u6001\u6c27\uff081<\/sup>O2<\/sub>\uff09\u751f\u6210\u7684\u7cbe\u786e\u63a7\u5236\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u674e\u4e50\u4e50\u548c\u8d75\u5b87\u4eae\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u5e76\u5408\u6210\u4e86\u4e00\u79cd\u7eb3\u7c73\u7ed3\u6784\u4ee5\u53ccNIR\u5149\u53ef\u7f16\u7a0b\u65b9\u5f0f\u751f\u62101<\/sup>O2<\/sub>\uff0c\u540c\u65f6\u8f6c\u79fb\u5230\u6cbb\u7597\u7a97\u53e3\u3002\u7eb3\u7c73\u7ed3\u6784\u662f\u901a\u8fc7\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u5305\u8986\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\uff08UCNPs\uff09\u800c\u6784\u5efa\u7684\uff0c\u5176\u4e2d\u535f\u5549\u5149\u654f\u5242\u5171\u4ef7\u5d4c\u5165\u4e8c\u6c27\u5316\u7845\u58c1\u5185\uff0c\u800cNIR\uff08808 nm\uff09\u54cd\u5e94\u7684\u4e8c\u82b3\u57fa\u4e59\u70ef\uff08DAE\uff09\u5149\u81f4\u53d8\u8272\u5f00\u5173\u88ab\u5c01\u88c5\u5230\u7845\u7eb3\u7c73\u7ba1\u7684\u7eb3\u7c73\u5b54\u4e2d\u3002\u7528980 nm NIR\u5149\u7167\u5c04\u65f6\uff0cUCNP\u6838\u5fc3\u5438\u6536\u4f4e\u80fd\u5149\u5b50\uff0c\u5e76\u5c06\u80fd\u91cf\u8f6c\u79fb\u5230\u4e8c\u6c27\u5316\u7845\u58c1\u4e2d\u7684PS\uff0c\u4ece\u800c\u6709\u6548\u5730\u4ea7\u751f1<\/sup>O2<\/sub>\u3002\u901a\u8fc7\u7528\u4e0d\u540c\u7684NIR\u6ce2\u957f\uff08808 nm\uff09\u8fdb\u884c\u8f90\u5c04\u6765\u8fdc\u7a0b\u63a7\u5236980 nm NIR\u5149\u7684\u5149\u654f\u6d3b\u6027\u3002\u5f53\u5c01\u88c5\u5728\u7eb3\u7c73\u5b54\u4e2d\u7684DAE\u5904\u4e8e\u5c01\u95ed\u5f62\u5f0f\u65f6\uff0c\u6291\u5236\u4e861<\/sup>O2<\/sub>\u7684\u4ea7\u751f\uff0c\u800c\u7528808nm NIR\u5149\u7167\u5c04\u7eb3\u7c73\u7ed3\u6784\u4f1a\u5bfc\u81f4DAE\u8f6c\u53d8\u4e3a\u5f00\u653e\u5f62\u5f0f\uff0c\u4ece\u800c\u80fd\u591f\u5b8c\u5168\u6062\u590d\u88ab\u6fc0\u53d1\u7684980 nm NIR\u51491<\/sup>O2<\/sub>\u4ea7\u751f\u80fd\u529b\u3002NIR\u5149\u4ecb\u5bfc\u7684\u7eb3\u7c73\u7ed3\u6784\u6309\u9700\u201c\u6fc0\u6d3b\u201d\u7528\u4e8e\u751f\u7269\u6210\u50cf\u548c\u53ef\u63a7\u5149\u52a8\u529b\u7597\u6cd5\u5df2\u5728\u4f53\u5916\u548c\u4f53\u5185\u5f97\u5230\u8bc1\u5b9e\u3002[6]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cA photochromic upconversion nanoarchitecture:\u00a0towards activatable bioimaging and dual NIR lightprogrammed\u00a0singlet oxygen generation\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728Chem. Sci.\u3002<\/p>\n

\u56fe\u516d\uff1a980 nm NIR\u5149\u654f\u5316\u7684UC @ PS \/ C-DAE\u7eb3\u7c73\u7ed3\u6784\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

7. Nat. Commun. NIR\u5149\u4ecb\u5bfc\u9009\u62e9\u6027\u89e6\u53d1\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u514d\u75ab\u88c5\u7f6e\u7684\u6297\u80bf\u7624\u514d\u75ab<\/b><\/strong><\/p>\n

\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u6b63\u5728\u6210\u4e3a\u764c\u75c7\u7684\u8303\u5f0f\u8f6c\u53d8\u7597\u6cd5\uff0c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u4ecd\u4f34\u6709\u80bf\u7624\u5916\u6bd2\u6027\u548c\u81ea\u8eab\u514d\u75ab\u4e0d\u826f\u53cd\u5e94\uff0c\u56e0\u6b64\u8feb\u5207\u9700\u8981\u5f00\u53d1\u9ad8\u65f6\u7a7a\u7cbe\u5ea6\u548c\u5b89\u5168\u6027\u667a\u80fd\u7cfb\u7edf\u6765\u8c03\u8282\u514d\u75ab\u53cd\u5e94\u3002\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u674e\u4e50\u4e50\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u53ef\u6fc0\u6d3b\u7684\u5de5\u7a0b\u514d\u75ab\u8bbe\u5907\uff0c\u8be5\u8bbe\u5907\u53ef\u901a\u8fc7\u8fd1\u7ea2\u5916\uff08NIR\uff09\u5149\u5728\u4f53\u5916\u548c\u4f53\u5185\u8fdc\u7a0b\u63a7\u5236\u6297\u80bf\u7624\u514d\u75ab\u529b\u3002\u514d\u75ab\u88c5\u7f6e\u7531\u53ef\u7d2b\u5916\u5149\u6fc0\u6d3b\u7684\u514d\u75ab\u523a\u6fc0\u5242\u548c\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u7ec4\u6210\uff0c\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\u7528\u4f5c\u6362\u80fd\u5668\u5c06\u88c5\u7f6e\u7684\u5149\u654f\u6027\u8f6c\u79fb\u5230NIR\u7a97\u53e3\u3002\u53d7\u63a7\u7684\u514d\u75ab\u8c03\u8282\u5141\u8bb8\u5728\u80bf\u7624\u5185\u4ea7\u751f\u6709\u6548\u7684\u514d\u75ab\u53cd\u5e94\u800c\u4e0d\u4f1a\u5e72\u6270\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\u7684\u514d\u75ab\uff0c\u4ece\u800c\u5728\u964d\u4f4e\u5168\u8eab\u6bd2\u6027\uff0c\u540c\u65f6\u4fdd\u6301\u6297\u80bf\u7624\u529f\u6548\u3002\u514d\u75ab\u88c5\u7f6e\u63d0\u4f9b\u4e86\u4e00\u79cd\u975e\u4fb5\u5165\u6027\u7b56\u7565\uff0c\u4ee5\u8f83\u9ad8\u7684\u65f6\u7a7a\u7cbe\u5ea6\u6765\u8fdc\u7a0b\u63a7\u5236\u514d\u75ab\u8c03\u8282\u6d3b\u6027\uff0c\u53ef\u4ee5\u964d\u4f4e\u7cfb\u7edf\u6bd2\u6027\u6765\u4e2a\u6027\u5316\u6297\u80bf\u7624\u529f\u80fd\u3002\u8be5\u65b9\u6cd5\u5c06\u4e3a\u4e0b\u4e00\u4ee3\u514d\u75ab\u6cbb\u7597\u7cfb\u7edf\u7684\u672a\u6765\u53d1\u5c55\u589e\u52a0\u4e00\u79cd\u65b0\u7684\u89c1\u89e3\u3002[7]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cNIR-light-mediated spatially selective triggering\u00a0of anti-tumor immunity via upconversion\u00a0nanoparticle-based immunodevices\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728Nat. Commun.\u3002<\/p>\n

\u56fe\u4e03\uff1a\u5149\u6fc0\u6d3b\u514d\u75ab\u88c5\u7f6e\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u5218\u5fd7\u6d2a\uff08\u6b66\u6c49\u5927\u5b66\/\u6e56\u5317\u5927\u5b66\uff09<\/b><\/strong><\/p>\n

8. Anal. Chem. HOCl\u6fc0\u6d3b\u548c\u8840\u8111\u5c4f\u969c\u6e17\u900f\u6027\u4e0a\u8f6c\u6362\u7eb3\u7c73\u63a2\u9488\u76d1\u6d4b\u795e\u7ecf\u708e\u75c7<\/p>\n

\u5bf9\u4e8e\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u89e3\u91ca\u548c\u6cbb\u7597\u8feb\u5207\u9700\u8981\u4e00\u79cd\u53ef\u9760\u7684\u5b9e\u65f6\u8ddf\u8e2a\u795e\u7ecf\u708e\u75c7\u8fdb\u5c55\u7684\u5de5\u5177\u3002\u6b66\u6c49\u5927\u5b66\/\u6e56\u5317\u5927\u5b66\u5218\u5fd7\u6d2a\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5177\u6709NIR\u53d1\u5c04\u7684\u8840\u8111\u5c4f\u969c\u6e17\u900f\u6027\u548cHOCl\u6fc0\u6d3b\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u63a2\u9488\u7528\u4e8e\u4f53\u5185\u795e\u7ecf\u708e\u75c7\u7684\u53ef\u89c6\u5316\u7814\u7a76\u3002\u8be5\u4e0a\u8f6c\u6362\u7eb3\u7c73\u63a2\u9488\u7531\u4e09\u90e8\u5206\u7ec4\u6210\uff1a\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\uff08UCNPs\uff09\u4f5c\u4e3a\u4fe1\u53f7\u5355\u5143\uff0cCy-HOCl\u67d3\u6599\u5145\u5f53UCNPs\u7684\u80fd\u91cf\u53d7\u4f53\u548cHOCl\u7684\u8bc6\u522b\u5355\u5143\uff0c\u4ee5\u53ca\u4f7f\u63a2\u9488\u5177\u6709\u751f\u7269\u76f8\u5bb9\u6027\u548c\u8840\u8111\u5c4f\u969c\u6e17\u900f\u6027\u7684\u4e24\u4eb2\u805a\u5408\u7269\u3002\u9759\u8109\u5185\u6ce8\u5c04\u7ed9\u5c0f\u9f20\u540e\uff0c\u8be5\u63a2\u9488\u901a\u8fc7\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\u76f8\u5173\u86cb\u767d\u4ecb\u5bfc\u7684\u80de\u541e\u4f5c\u7528\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u7136\u540e\u5728\u795e\u7ecf\u708e\u75c7\u8fc7\u7a0b\u4e2d\u88ab\u8fc7\u91cf\u4ea7\u751f\u7684HOCl\u523a\u6fc0\u6062\u590d\u8367\u5149\u3002\u8be5\u63a2\u9488\u80fd\u591f\u533a\u5206\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\u76f8\u5173\u86cb\u767d\u8bf1\u5bfc\u7684\u795e\u7ecf\u4e2d\u7684\u708e\u75c7\u548c\u5927\u8111\u7684\u6b63\u5e38\u72b6\u6001\uff0c\u5e76\u76d1\u6d4b\u8111\u5352\u4e2d\u5c0f\u9f20\u4e2d\u795e\u7ecf\u708e\u75c7\u7684\u8fdb\u5c55\uff0c\u4ece\u800c\u4e3a\u795e\u7ecf\u708e\u75c7\u7684\u65e0\u521b\u548c\u53ef\u89c6\u5316\u8bc4\u4f30\u63d0\u4f9b\u4e86\u5b9e\u7528\u5de5\u5177\u3002[8]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cMonitoring Neuroinflammation with an HOCl-Activatable and\u00a0Blood-Brain Barrier Permeable Upconversion Nanoprobe\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728Anal. Chem.\u3002<\/p>\n

\u56fe\u516b\uff1a\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\u76f8\u5173\u86cb\u767d\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\u4ee5\u53ca\u795e\u7ecf\u708e\u75c7\u533a\u57df\u5bf9HOCl\u63a2\u9488\u54cd\u5e94\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

9. Adv. Funct. Mater. \u6d88\u9664\u67d3\u6599\u654f\u5316\u7684\u4e0a\u8f6c\u6362<\/b><\/strong>\u6750\u6599<\/b><\/strong>\u5728\u6c34\u76f8\u4e2d\u7684\u969c\u788d\u5b9e\u73b0\u4f53\u5185\u9ad8\u5bf9\u6bd4\u5ea6\u7684\u6df1\u5c42\u6210\u50cf<\/b><\/strong><\/p>\n

\u5c3d\u7ba1\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\uff08UCNPs\uff09\u56e0\u5176\u72ec\u7279\u7684\u5149\u7269\u7406\u7279\u6027\u800c\u53d7\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\uff0c\u4f46\u7531\u4e8eLn3+<\/sup>\u7684\u5438\u6536\u7cfb\u6570\u4f4e\uff0c\u5b83\u4eec\u5177\u6709\u53d1\u5149\u6548\u7387\u4f4e\u7684\u74f6\u9888\u3002\u7531\u4e8e\u663e\u7740\u63d0\u9ad8\u7684\u5149\u5438\u6536\u80fd\u529b\uff0c\u67d3\u6599\u654f\u5316\u4f5c\u7528\u5728\u6709\u673a\u6eb6\u5242\u4e2d\u63d0\u4f9b\u4e86\u4e0a\u5343\u500d\u7684\u4e0a\u8f6c\u6362\u53d1\u5149\uff08UCL\uff09\u589e\u5f3a\uff0c\u4f46\u662f\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5728\u672a\u77e5\u7684\u9650\u5236\u56e0\u7d20\u4e0b\uff0c\u6c34\u76f8\u4e2d\u7684UCL\u654f\u5316\u4f5c\u7528\u4e0d\u523020\u500d\u3002\u6b66\u6c49\u5927\u5b66\/\u6e56\u5317\u5927\u5b66\u5218\u5fd7\u6d2a\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u901a\u8fc7\u7cbe\u7ec6\u8c03\u8282\u67d3\u6599\u6027\u8d28\u53ca\u5176\u4e0eUCNPs\u7684\u7ec4\u88c5\u65b9\u5f0f\u53ef\u4ee5\u6539\u53d8\u654f\u5316\u6548\u7387\u3002UCNPs\u8868\u9762\u4e0a\u7684\u67d3\u6599\u805a\u96c6\u51fa\u73b0\u805a\u96c6\u731d\u706d\u6548\u5e94\uff0c\u4ece\u800c\u9650\u5236\u5728\u6c34\u76f8\u4e2dUCL\u7684\u654f\u5316\u6548\u7387\u3002\u901a\u8fc7\u5229\u7528\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u6765\u5236\u5907\u67d3\u6599\u654f\u5316\u7684UCNPs\uff0c\u67d3\u6599\u5206\u5b50\u53ef\u5728\u758f\u6c34\u5c42\u4e2d\u81ea\u7531\u6269\u6563\uff0c\u5e76\u4e14\u80fd\u6709\u6548\u7684\u907f\u514d\u67d3\u6599\u5206\u5b50\u7684\u805a\u96c6\u3002\u901a\u8fc7\u7cbe\u7ec6\u8c03\u6574\u67d3\u6599\u7684\u7ed3\u6784\u5c06\u5176\u5438\u6536\u5e26\u4e0eUCNPs\u7684\u53d1\u5c04\u5e26\u5206\u5f00\uff0c\u4ece\u800c\u51cf\u8f7b\u4eceLn3+<\/sup>\u5230\u67d3\u6599\u7684\u80fd\u91cf\u53cd\u5411\u8f6c\u79fb\uff0c\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u4e86UCL\u7684\u654f\u5316\u4f5c\u7528\uff0c\u5e76\u5728\u6c34\u76f8\u4e2d\u5b9e\u73b0\u4e86UCL\u589e\u5f3a\u8d85\u8fc7600\u500d\u4ee5\u4e0a\u3002\u5229\u7528\u4f53\u5185\u751f\u7269\u6210\u50cf\u6280\u672f\uff0c\u7814\u7a76\u4e86\u8fd9\u79cdUCNPs\u7684\u6027\u80fd\uff0c\u5176\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u8f83\u9ad8\u7684\u4fe1\u53f7\u5bf9\u6bd4\u5ea6\u3002[9]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cRemoving the Obstacle of Dye-Sensitized Upconversion\u00a0Luminescence in Aqueous Phase to Achieve High-Contrast\u00a0Deep Imaging In Vivo\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728Adv. Funct. Mater.\u3002<\/p>\n

\u56fe\u4e5d\uff1a\u63a2\u7a76\u9650\u5236\u6c34\u76f8\u4e2d\u67d3\u6599\u654f\u5316UCL\u7684\u5173\u952e\u56e0\u7d20<\/b><\/strong><\/p>\n

\"\"<\/p>\n

10. Chem. Commun. NIR\u53d1\u5c04\u91cf\u5b50\u70b9\u5bf9\u4e0a\u8f6c\u6362\u53d1\u5149\u7684\u9776\u6807\u8c03\u5236\u654f\u5316\uff1a\u6784\u5efa\u4e0a\u8f6c\u6362\u751f\u7269\u4f20\u611f\u5668\u7684\u65b0\u7b56\u7565<\/b><\/strong><\/p>\n

\u67d3\u6599\u654f\u5316\u4ee5\u589e\u5f3a\u4e0a\u8f6c\u6362\u53d1\u5149\uff08UCL\uff09\u662f\u56e0\u4e3a\u67d3\u6599\u7684\u5438\u5149\u5ea6\u9ad8\u4e8e\u9567\u7cfb\u5143\u7d20\u79bb\u5b50\uff0c\u67d3\u6599\u53ef\u4ee5\u5438\u6536\u5149\u5b50\u7684\u80fd\u91cf\uff0c\u5e76\u901a\u8fc7\u975e\u8f90\u5c04\u80fd\u91cf\u8f6c\u79fb\u8fc7\u7a0b\u5c06\u5176\u6fc0\u53d1\u6001\u80fd\u91cf\u8f6c\u79fb\u5230UCNPs\u3002\u7531\u4e8e\u5927\u591a\u6570NIR\u67d3\u6599\u7684\u91cf\u5b50\u4ea7\u7387\u4f4e\u4e14\u65af\u6258\u514b\u65af\u4f4d\u79fb\u5c0f\uff0c\u56e0\u6b64\u4f7f\u7528\u5408\u9002\u7684NIR\u67d3\u6599\u4f5c\u4e3a\u654f\u5316\u5242\u662f\u6025\u9700\u89e3\u51b3\u7684\u95ee\u9898\u4e4b\u4e00\u3002\u6b66\u6c49\u5927\u5b66\/\u6e56\u5317\u5927\u5b66\u5218\u5fd7\u6d2a\u8bfe\u9898\u7ec4\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u7684\u7b56\u7565\uff1a\u57fa\u4e8e\u91cf\u5b50\u70b9\u76f4\u63a5\u589e\u5f3aUCL\u6784\u5efa\u4e0a\u8f6c\u6362\u751f\u7269\u4f20\u611f\u5668\u7528\u4e8e\u68c0\u6d4b\u51dd\u8840\u9176\u3002\u9009\u62e9\u5728980 nm\u9644\u8fd1\u5177\u6709\u5f3a\u53d1\u5c04\u7684Ag2<\/sub>Se\u91cf\u5b50\u70b9\u4f5c\u4e3a\u80fd\u91cf\u4f9b\u4f53\u548c\u654f\u5316\u5242\uff0c\u4ee5\u5339\u914dYb3+<\/sup>\u7684\u5438\u6536\u3002\u5047\u8bbe\u76ee\u6807\u51dd\u8840\u9176\u4f7f\u5b83\u4eec\u7d27\u5bc6\u63a5\u8fd1\uff0cAg2<\/sub>Se\u91cf\u5b50\u70b9\u80fd\u591f\u4ece\u6fc0\u53d1\u5149\u4e2d\u6536\u96c6\u80fd\u91cf\u5e76\u5c06\u5176\u6fc0\u53d1\u6001\u80fd\u91cf\u901a\u8fc7\u975e\u8f90\u5c04\u80fd\u91cf\u8f6c\u79fb\u8fc7\u7a0b\u8f6c\u79fb\u5230Yb3+<\/sup>\u3002\u4e3a\u4e86\u907f\u514d\u8fd9\u4e24\u79cd\u7eb3\u7c73\u9897\u7c92\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5e76\u4fc3\u8fdb\u968f\u540e\u7684\u751f\u7269\u5b66\u4fee\u9970\uff0c\u5c06\u5b83\u4eec\u90fd\u7528\u7fa7\u57fa\u5b98\u80fd\u5316\uff0c\u4e24\u79cd\u51dd\u8840\u9176\u9002\u4f53\u5206\u522b\u901a\u8fc7DNA\u672b\u7aef\u4fee\u9970\u7684\u6c28\u57fa\u5171\u4ef7\u8fde\u63a5\u5230UCNPs\u548cAg2<\/sub>Se \u91cf\u5b50\u70b9\u7684\u8868\u9762\u3002\u5f15\u5165\u7684\u51dd\u8840\u9176\u5c06\u540c\u65f6\u4e0e\u8fd9\u4e24\u4e2a\u9002\u4f53\u7ed3\u5408\u5e76\u5f62\u6210\u51dd\u8840\u9176-\u9002\u4f53\u590d\u5408\u7269\uff0c\u4ece\u800c\u7f29\u77ed\u4e86Ag2<\/sub>Se\u91cf\u5b50\u70b9\u548cUCNP\u4e4b\u95f4\u7684\u8ddd\u79bb\u5e76\u89e6\u53d1\u4e86\u80fd\u91cf\u8f6c\u79fb\uff0cUCNPs\u7684UCL\u589e\u5f3a\u53d6\u51b3\u4e8e\u51dd\u8840\u9176\u7684\u6d53\u5ea6\u3002\u8be5\u7b56\u7565\u91c7\u7528\u5176\u4ed6\u8bc6\u522b\u6a21\u5f0f\u53ef\u6269\u5c55\u5230\u5176\u4ed6\u5206\u6790\u7269\uff0c\u8fd9\u4e3a\u751f\u7269\u533b\u5b66\u7814\u7a76\u548c\u4e34\u5e8a\u4e2d\u63d0\u4f9b\u4e00\u79cd\u65b0\u7684\u8bca\u65ad\u65b9\u5f0f\u3002[10]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cTarget-modulated sensitization of upconversion\u00a0luminescence by NIR-emissive quantum dots:\u00a0a new strategy to construct upconversion\u00a0biosensors\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728Chem. Commun.\u3002<\/p>\n

\u56fe\u5341\uff1a\u57fa\u4e8eAg<\/b><\/strong>2<\/b><\/sub><\/strong>Se\u91cf\u5b50\u70b9\u5bf9UCL\u7684\u589e\u5f3a\u8c03\u8282\u7528\u4e8e\u51dd\u8840\u9176\u68c0\u6d4b\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

11. ACS Appl. Mater. Interfaces<\/b><\/strong>\u4ee5\u91cf\u5b50\u70b9\u4e3a\u654f\u5316\u5242\u7684\u4e0a\u8f6c\u6362\u7cfb\u7edf\uff1a\u6539\u8fdb\u7684\u5149\u81f4\u53d1\u5149\u548cPDT\u6548\u7387<\/b><\/strong><\/p>\n

\u4e0a\u8f6c\u6362\u7eb3\u7c73\u7c92\u5b50\uff08UCNPs\uff09\u662f\u751f\u7269\u6210\u50cf\u548c\u5149\u7597\u7684\u6f5c\u5728\u5e73\u53f0\uff0c\u4f46\u662f\u7531\u4e8e\u9567\u7cfb\u5143\u7d20\u79bb\u5b50\u7684\u5fae\u5f31\u5438\u6536\u6027\u548c\u4f4e\u91cf\u5b50\u4ea7\u7387\u800c\u5bfc\u81f4\u4eae\u5ea6\u53d7\u9650\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u6b66\u6c49\u5927\u5b66\/\u6e56\u5317\u5927\u5b66\u5218\u5fd7\u6d2a\u8bfe\u9898\u7ec4\u63d0\u51fa\u4f7f\u7528\u534a\u5bfc\u4f53\u91cf\u5b50\u70b9\u4f5c\u4e3aNd3+<\/sup>\u00a0\/ Yb3+<\/sup>\u5171\u63ba\u6742UCNPs\u7684\u5149\u654f\u5242\u6784\u5efaUCNPs\u7684\u80fd\u91cf\u7ea7\u8054\u7684\u7b56\u7565\u3002Ag2<\/sub>Se\u91cf\u5b50\u70b9\u5728808 nm\u5904\u5177\u6709\u5f88\u5f3a\u7684\u5438\u6536\u4f5c\u7528\uff0c\u5145\u5f53\u6709\u6548\u7684\u5929\u7ebf\uff0c\u5e76\u901a\u8fc7\u5171\u632f\u80fd\u91cf\u8f6c\u79fb\u8fc7\u7a0b\u5c06\u5176\u80fd\u91cf\u8f6c\u79fb\u5230Yb3+<\/sup>\uff0c\u4ece\u800c\u5927\u5927\u589e\u5f3a\u4e86UCNP\u7684\u53d1\u5149\u3002\u5c06\u8be5\u7eb3\u7c73\u590d\u5408\u6750\u6599\u4e0e\u73ab\u7470\u7ea2\u7ed3\u5408\uff0c\u5e76\u7528\u4e8e\u5149\u52a8\u529b\u7597\u6cd5\u3002\u4f53\u5916\u548c\u4f53\u5185\u7814\u7a76\u5747\u8868\u660e\uff0c\u5f15\u5165\u91cf\u5b50\u70b9\u663e\u7740\u6539\u5584\u4e86\u6cbb\u7597\u6027\u80fd\u3002\u8be5\u7814\u7a76\u8868\u660e\uff0c\u5177\u6709\u4f18\u5f02\u5149\u7269\u7406\u6027\u8d28\u7684Ag2<\/sub>Se\u91cf\u5b50\u70b9\u53ef\u4ee5\u6210\u4e3a\u514b\u670dUCNPs\u7f3a\u70b9\u5e76\u8fdb\u4e00\u6b65\u6269\u5c55\u5176\u5e94\u7528\u524d\u666f\u3002[11]<\/sup>\u76f8\u5173\u6210\u679c\u4ee5\u201cUpconversion System with Quantum Dots as Sensitizer: Improved\u00a0Photoluminescence and PDT Efficiency\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728ACS Appl. Mater. Interfaces\u3002<\/p>\n

\u56fe\u5341\u4e00\uff1a\u91cf\u5b50\u70b9\u654f\u611f\u7684Nd<\/b><\/strong>3+<\/b><\/sup><\/strong>\u00a0\/ Yb<\/b><\/strong>3+<\/b><\/sup><\/strong>\u5171\u63ba\u6742\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u6750\u6599\u4e2d\u80fd\u91cf\u8f6c\u79fb\u8fc7\u7a0b\u53caUCNPs-\u91cf\u5b50\u70b9\u4e0e\u5149\u654f\u5242\u7ed3\u5408\u7528\u4e8ePDT\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n

    \n
  1. Song X., Li S., Guo H., You W., Shang X., Li R., Tu D.,Zheng W., Chen Z., Yang H.,Chen X., Graphene-Oxide-Modified Lanthanide Nanoprobes for Tumor-Targeted Visible\/NIR-II Luminescence Imaging. [J] Angew. Chem. Int. Ed. 2019, 58, 18981-18986.<\/li>\n
  2. Ke J., Lu S., Shang X., Liu Y., Guo H., You W., Li X.,Xu J., Li R., Chen Z., Chen X.,A Strategy of NIR Dual-Excitation Upconversion\u00a0for Ratiometric Intracellular Detection. [J] Adv. Sci. 2019, 6, 1901874.<\/li>\n
  3. Guo H., Song X., Lei W., He C., You W., Lin Q.,Zhou S., Chen X.,Chen Z.,\u00a0Direct Detection of Circulating Tumor Cells in Whole Blood Using\u00a0Time-Resolved Luminescent Lanthanide Nanoprobes. [J] Angew. Chem. Int. Ed. 2019, 58, 12195-12199.<\/li>\n
  4. Shao Y., Liu B., Di Z., Zhang G., Sun L., Li L.,Yan C., Engineering of Upconverted Metal-Organic Frameworks for Near-Infrared Light-Triggered Combinational Photodynamic\/Chemo-\/Immunotherapy against Hypoxic Tumors. [J] J. Am. Chem. Soc. 2020, 142, 3939-3946.<\/li>\n
  5. Liu C., Liu B., Zhao J., Di Z., Chen D., Gu Z., Li L., Zhao Y., Nd3+<\/sup>-Sensitized Upconversion Metal-Organic Frameworks forMitochondria-Targeted Amplified Photodynamic Therapy. [J] Angew. Chem. Int. Ed. 2020, 59, 2634-2638.<\/li>\n
  6. Mi Y.,Cheng H.,Chu H.,\u00a0Zhao J.,\u00a0Yu M., Gu Z.,\u00a0Zhao Y.,\u00a0Li L., A photochromic upconversion nanoarchitecture:\u00a0towards activatable bioimaging and dual NIR lightprogrammed\u00a0singlet oxygen generation. [J] Chem. Sci., 2019, 10, 10231-10239.<\/li>\n
  7. Chu H., Zhao J., Mi Y., Di Z.,Li L., NIR-light-mediated spatially selective triggeringof anti-tumor immunity via upconversion\u00a0nanoparticle-based immunodevices. [J] Nat. Commun.\u00a02019, 10, 2839.<\/li>\n
  8. Zhang M., Zuo M., Wang C., Li Z., Cheng Q., Huang J., Wang Z.,Liu Z., Monitoring Neuroinflammation with an HOCl-Activatable andBlood-Brain Barrier Permeable Upconversion Nanoprobe. [J] Anal. Chem. 2020, 92, 5569-5576.<\/li>\n
  9. Liang T., Wang Q., Li Z.,Wang P., Wu J., Zuo M., Liu Z., Removing the Obstacle of Dye-Sensitized UpconversionLuminescence in Aqueous Phase to Achieve High-Contrast\u00a0Deep Imaging In Vivo. [J] Adv. Funct. Mater. 2020, 1910765.<\/li>\n
  10. Yu T.,Wei D.,Li Z., Pan L., Zhang Z.,\u00a0Tian Z.,\u00a0Liu Z., Target-modulated sensitization of upconversion\u00a0luminescence by NIR-emissive quantum dots:\u00a0a new strategy to construct upconversion\u00a0biosensors. [J] Chem. Commun., 2020, 56, 1976-1979.<\/li>\n
  11. Song D.,Chi S., Li X.,Wang C.,\u00a0Li Z.,\u00a0Liu Z., Upconversion System with Quantum Dots as Sensitizer: Improved\u00a0Photoluminescence and PDT Efficiency. [J] ACS Appl. Mater. Interfaces 2019, 11, 41100-41108.<\/li>\n<\/ol>\n

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