{"id":200624,"date":"2020-05-02T06:39:28","date_gmt":"2020-05-01T22:39:28","guid":{"rendered":"\/\/m.iemloyee.com\/?p=200624"},"modified":"2020-05-01T21:39:52","modified_gmt":"2020-05-01T13:39:52","slug":"sci-adv-%ef%bc%9a%e5%ae%89%e5%85%a8%e3%80%81%e7%a8%b3%e5%ae%9a%e5%85%89%e7%83%adtese%e7%ba%b3%e7%b1%b3%e5%bc%82%e8%b4%a8%e5%bd%bb%e5%ba%95%e6%a0%b9%e9%99%a4%e5%b0%8f%e9%bc%a0%e8%82%bf%e7%98%a4","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=200624","title":{"rendered":"Sci. Adv.\uff1a\u5b89\u5168\u3001\u7a33\u5b9a\u5149\u70edTeSe\u7eb3\u7c73\u5f02\u8d28\u5f7b\u5e95\u6839\u9664\u5c0f\u9f20\u80bf\u7624"},"content":{"rendered":"
\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n \u5177\u6709\u6539\u5584\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u66f4\u9ad8\u7684\u5149\u70ed\u6548\u5e94\u4ee5\u53ca\u9644\u52a0\u7684\u540c\u65f6\u529f\u80fd\u7684\u65b0\u51742D\u7eb3\u7c73\u6750\u6599\u4e3a\u751f\u7269\u533b\u5b66\u5e94\u7528\u63cf\u7ed8\u4e86\u5e7f\u9614\u7684\u524d\u666f\u3002\u4f46\u662f\uff0c\u5728\u60a3\u8005\u4e34\u5e8a\u4f7f\u7528\u4e4b\u524d\uff0c\u8be5\u9886\u57df\u4e2d\u7684\u4e00\u4e9b\u6311\u6218\u6027\u95ee\u9898\u4ecd\u4e9f\u5f85\u89e3\u51b3\u3002\u4e3b\u8981\u5305\u542b\u751f\u7269\u5b89\u5168\u6027\uff08\u77ed\u671f\u548c\u957f\u671f\u7684\u5b89\u5168\u95ee\u9898\uff09\u3001\u5b9e\u73b0\u5bf9\u73b0\u6709\u65b9\u6cd5\u7684\u9ad8\u7597\u6548\u6216\u4e0e\u5e38\u89c4\u7597\u6cd5\u76f8\u7ed3\u5408\u7684\u534f\u540c\u529f\u6548\u3001\u4e34\u5e8a\u6cbb\u7597\u7684\u7eb3\u7c73\u6750\u6599\u7684\u975e\u5747\u8d28\u6027\u4ee5\u53ca\u7a33\u5b9a\u6027\u548c\u751f\u7269\u53ef\u964d\u89e3\u6027\u80fd\u7b49\u3002\u4e8c\u7ef4\u7eb3\u7c73\u6750\u6599\u5728\u80bf\u7624\u6cbb\u7597\u9886\u57df\u6709\u7740\u72ec\u7279\u7684\u4f18\u52bf\uff0c\u53ef\u4ee5\u5f88\u597d\u7684\u89e3\u51b3\u4e0a\u8ff0\u96be\u9898\uff0c\u4f46\u662f\u5927\u591a\u6570\u6db2\u76f8\u5265\u79bb\u7684\u4e8c\u7ef4\u7eb3\u7c73\u6750\u6599\u5f62\u72b6\u4e0d\u5747\u5300\uff0c\u8fd9\u662f\u4e8c\u7ef4\u6750\u6599\u5728\u5e94\u7528\u4e2d\u7684\u5171\u540c\u96be\u9898\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n \u8fd1\u65e5\uff0c\u6df1\u5733\u5927\u5b66\u5f20\u6657\u6559\u6388\u3001\u745e\u5178\u5361\u7f57\u6797\u65af\u5361\u533b\u5b66\u9662\u66f9\u4e49\u6d77\u9662\u58eb\u548c\u6df1\u5733\u5e02\u4eba\u6c11\u533b\u9662\u5218\u5229\u5e73\u526f\u6559\u6388<\/strong>\u8054\u5408\u5236\u5907\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u4e8c\u7ef4\u6a2a\u5411\u5f02\u8d28\u7ed3\uff0c\u5373\u7852\u5305\u8986\u7684\u78b2\u7eb3\u7c73\u5f02\u8d28\u7ed3\u3002\u65b0\u5408\u6210\u7684TeSe\u5177\u6709\u8f83\u9ad8\u7684\u7a33\u5b9a\u6027\uff0c\u751f\u7269\u76f8\u5bb9\u826f\u597d\u4e14\u5c3a\u5bf8\u9ad8\u5ea6\u5747\u5300\u3002\u76f8\u5bf9\u4e8e\u5176\u4ed6\u5065\u5eb7\u7ec4\u7ec7\uff0cTeSe\u7eb3\u7c73\u7c92\u5b50\u5728\u5c0f\u9f20\u4e2d\u7684\u7cfb\u7edf\u6027\u9012\u9001\u5728\u80bf\u7624\u4e2d\u663e\u793a\u51fa\u9ad8\u5ea6\u7279\u5f02\u6027\u7684\u79ef\u7d2f\u3002\u5149\u7167\u65f6\uff0cTeSe\u7eb3\u7c73\u9897\u7c92\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u51e0\u4e4e\u53ef\u4ee5\u5b8c\u5168\u6839\u9664\u80ba\u764c\u548c\u809d\u7ec6\u80de\u764c\u3002\u4e0e\u80bf\u7624\u6291\u5236\u4e00\u81f4\uff0cPTT\u6539\u53d8\u4e86\u80bf\u7624\u7684\u5fae\u200b\u200b\u73af\u5883\u5e76\u8bf1\u5bfc\u4e86\u764c\u7ec6\u80de\u51cb\u4ea1\u3002\u4f5c\u8005\u5c55\u793a\u4e86TeSe\u7eb3\u7c73\u6750\u6599\u7684\u6297\u764c\u529f\u6548\u3001\u673a\u5236\u53ca\u5176\u5bf9\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u6539\u53d8\u7684\u5f71\u54cd\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cEradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aSci. Adv.<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n \u56fe\u4e00\u3001<\/strong>TeSe<\/strong>\u7eb3\u7c73\u6750\u6599\u7684\u5f62\u8c8c\u8868\u5f81<\/strong><\/p>\n TeSe\u7684\u7eb3\u7c73\u7ed3\u6784\u7684TEM\u56fe\u50cf\uff08A-H\uff09\uff0cAFM\u56fe\u50cf\uff08I-L\uff09\u4ee5\u53ca\u76f8\u5e94\u7684\u9ad8\u5ea6\u7ebf\u8f6e\u5ed3\uff08M\uff09\u548c\u539a\u5ea6\u7edf\u8ba1\u5206\u6790\uff08N\uff09\u3002\u56db\u79cd\u7eb3\u7c73\u6750\u6599\u5206\u522b\u4e3aTeSe(1:0.25), TeSe(1:0.5), TeSe(1:0.75), TeSe(1:1)\u3002<\/p>\n \u56fe\u4e8c\u3001<\/strong>TeSe<\/strong>\u7eb3\u7c73\u6750\u6599\u7684\u7406\u5316\u6027\u8d28\u8868\u5f81<\/strong><\/p>\n \uff08A\uff09TEM\u56fe\u50cf\u663e\u793a\u4e09\u4e2a\u7eb3\u7c73\u9897\u7c92\u53ca\u5176\u4e4b\u95f4\u7684\u7a7a\u95f4\u3002<\/p>\n \uff08B\uff09\u5bf9\u5e94\u7684Te\u5143\u7d20mapping\u56fe\u50cf\u3002<\/p>\n \uff08C\uff09\u5bf9\u5e94\u7684Se\u5143\u7d20mapping\u56fe\u50cf\u3002<\/p>\n \uff08D\uff09\u96c6\u6210Te\u548cSe\u5143\u7d20mapping\u56fe\u50cf\u3002<\/p>\n \uff08E\uff09\u5bf9\u5e94\u7684O\u5143\u7d20mapping\u56fe\u50cf\u3002<\/p>\n \uff08F\uff09\u96c6\u6210\u7684Te\uff0cSe\u548cO\u5143\u7d20mapping\u56fe\u50cf\u3002<\/p>\n \uff08G\uff09\u5bf9\u5e94\u7684C\u5143\u7d20mapping\u56fe\u50cf\u3002<\/p>\n \uff08H-I\uff09HRTEM\u56fe\u50cf\u663e\u793a\u6676\u4f53\u8fb9\u7f18\u975e\u6676\u533a\u548c\u8868\u9762\u539f\u5b50\u6392\u5217\u3002<\/p>\n \uff08J\uff09\u63d0\u51fa\u4e86\u5728PVP\u94fe\u548c\u7eb3\u7c73\u7ebf\u5b58\u5728\u4e0bTe\u548cSe\u539f\u5b50\u6392\u5217\u7684\u793a\u610f\u56fe\u548c\u692d\u5706\u5f62\u72b6\uff0c\u5206\u522b\u89e3\u91ca\u4e86Te\u548cSe\u5728\u4e00\u7ef4\u548c\u4e8c\u7ef4\u51e0\u4f55\u4e2d\u7684\u5173\u7cfb\u3002<\/p>\n \uff08K-L\uff09Te111<\/sub>O3<\/sub>\u548cSe54<\/sub>Te57<\/sub>O3<\/sub>\u7684\u6a21\u62df\u6c27\u5316\u539f\u5b50\u7ed3\u6784\u3002<\/p>\n \uff08M-N\uff09Te 3d\u548cSe 3d\u7684XPS\u56fe\u50cf\u3002<\/p>\n \uff08O\uff09200\u81f31200 nm\u8303\u56f4\u5185\u7684\u7d2b\u5916\u7ebf-\u53ef\u89c1\u5438\u6536\u5149\u8c31\u3002<\/p>\n \uff08P\uff09TeSe\uff081\uff1a1\uff09\u6837\u54c1\u7684\u5149\u70ed\u8f6c\u5316\u6548\u7387\uff08\u03b7\uff09\uff0c808 nm\uff0c1.0 W\/cm2<\/sup>\u3002<\/p>\n \uff08R\uff09\u5149\u70ed\u7684\u7a33\u5b9a\u6027\uff0c808 nm\uff0c1.0 W\/cm2<\/sup>\u3002<\/p>\n \u56fe\u4e09\u3001<\/strong>TeSe<\/strong>\u7eb3\u7c73\u6750\u6599\u7684\u751f\u7269\u5b89\u5168\u6027\u8bc4\u4f30<\/strong><\/p>\n \uff08A\uff09\u8bc4\u4f30SMMC-7721\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u529b\u3002<\/p>\n \uff08B\uff09\u5728\u5404\u79cd\u5b58\u50a8\u65f6\u95f4\uff080\u30013\u548c6\u5929\uff09\u4e0b\uff0c\u5728\u76d0\u6c34\uff081000 ppm\uff09\u4e2d\u7684\u7eafTe\u7eb3\u7c73\u6750\u6599\u7684\u7167\u7247\u3002<\/p>\n \uff08C\uff09\u4e0d\u540c\u65f6\u95f4\u540eTe\u5206\u6563\u4f53\u7684\u5438\u5149\u5ea6\u66f2\u7ebf\u3002<\/p>\n \uff08D\uff09\u5728\u76d0\u6c34\u4e2d\u50a8\u5b586\u5929\u540e\u7684TeSe\u6837\u54c1\u7684\u7167\u7247\u3002<\/p>\n \uff08E\uff09\u5728\u76d0\u6c34\u4e2d\u4e0d\u540c\u5b58\u50a8\u65f6\u95f4\uff081\u30017\u300115\u548c30\u5929\uff09\u7684TeSe\uff081\uff1a1\uff09\uff08250 ppm\uff09\u7684\u7167\u7247\u3002<\/p>\n \uff08F\uff09\u5728\u6307\u5b9a\u5929\u6570\u540eTeSe\uff081\uff1a1\uff09\u5206\u6563\u4f53\u7684\u5438\u6536\u66f2\u7ebf\u3002<\/p>\n \uff08G\uff09\u6ce8\u5c04\u4e0d\u540c\u5242\u91cf\uff081.0\u30011.5\u548c3.0 mg\/kg\uff09\u4e0d\u540c\u5206\u6563\u65f6\u95f4\uff080\u30013\u548c6\u5929\uff09\u7684\u7eafTe\u7eb3\u7c73\u6750\u6599\u540e\uff0c\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n \uff08H\uff09\u4ee5\u4e0d\u540c\u7684\u6ce8\u5c04\u5242\u91cf\uff081.0\u30011.5\u30013.0\u548c6.0mg\/kg\uff09\u5b58\u50a8\u7684\u5404\u79cd\u6301\u7eed\u65f6\u95f4\uff080\u30013\u548c6\u5929\uff09\u548c\u6ce8\u5c04TeSe\uff081\uff1a1\uff09\u540e\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n \uff08I\uff09\u6ce8\u5c04\u76d0\u6c34\uff0c\u5a92\u4ecb\u7269\uff08PVP\uff09\u548cTeSe\uff081\uff1a1\uff09\u540e\u7684\u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u3002<\/p>\n \u56fe\u56db\u3001<\/strong>TeSe<\/strong>\u7eb3\u7c73\u6750\u6599\u7684\u80bf\u7624\u9776\u5411\u6548\u7387\u7814\u7a76<\/strong><\/p>\n \u7ed9A549\u8377\u7624\u5c0f\u9f20\u9759\u8109\u6ce8\u5c04TeSe\u7eb3\u7c73\u6750\u6599\uff082 mg\/kg\uff09\uff0c\u5e76\u8d1f\u8f7d\u76f8\u540c\u91cf\u7684Cy7\u67d3\u6599\u3002\uff08A-B\uff09\u5728\u6240\u793a\u7684\u65f6\u95f4\u70b9\uff0c\u6d4b\u91cf\u80bf\u7624\u90e8\u4f4d\u7684\u8367\u5149\u5f3a\u5ea6\uff0c\u5e76\u8ba1\u7b97\u65f6\u95f4\u4f9d\u8d56\u6027\u5f3a\u5ea6\u3002<\/p>\n \uff08C\uff09\u6ce8\u5c04\u540e24\u5c0f\u65f6\uff0c\u5206\u79bb\u51fa\u80bf\u7624\u548c\u4e3b\u8981\u5668\u5b98\u7684\u8367\u5149\u5f3a\u5ea6\u3002<\/p>\n \uff08D\uff09\u5728\uff08C\uff09\u4e2d\u7684\u5668\u5b98\u548c\u80bf\u7624\u7684\u76f8\u5bf9\u4f4d\u7f6e\u7684\u56fe\u793a\u3002<\/p>\n \uff08E-F\uff09\u4e0d\u540c\u6750\u6599\uff0c\u4e0d\u540c\u5668\u5b98\u7684\u76f8\u5bf9\u8367\u5149\u5f3a\u5ea6\u3002<\/p>\n \u56fe\u4e94\u3001\u4f53\u5185\u5916\u5149\u70ed\uff08<\/strong>PTT<\/strong>\uff09\u6297\u80bf\u7624<\/strong><\/p>\n \uff08A\uff09\u4e0d\u540c\u6d53\u5ea6\u4e0d\u540c\u6750\u6599\u5bf9SMMC-7721\u7ec6\u80de\u5b58\u6d3b\u7387\u7684\u5f71\u54cd\uff08808 nm\uff0c1.0 W\/cm-2<\/sup>\uff0c10 min\uff09\u3002<\/p>\n \uff08B\uff09TeSe\uff081:1\uff09\u4e0e\u4e0d\u540c\u7ec6\u80de\u5b75\u80b2\u5149\u7167\u4e0d\u540c\u65f6\u95f4\u540e\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\uff08100 ppm\uff0c808 nm\uff0c1.0 W\/cm-2<\/sup>\uff09\u3002<\/p>\n \uff08C\uff09\u4e0d\u540c\u5149\u7167\u5f3a\u5ea6\u4e0b\uff0cTeSe\uff081:1\uff09\u4e0e\u4e0d\u540c\u7ec6\u80de\u5b75\u80b2\u540e\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\uff08100 ppm\uff0c808 nm\uff0c10 min\uff09\u3002<\/p>\n \uff08D\uff09\u5728\u6fc0\u5149\u7167\u5c04\u671f\u95f4\u4e0d\u540c\u5904\u7406\u7ec4\u80bf\u7624\u90e8\u4f4d\u5904\u7684\u6e29\u5ea6\u53d8\u5316\u3002<\/p>\n \uff08E\uff09\u5b9e\u65f6\u76d1\u63a7\uff08D\uff09\u7684\u6e29\u5ea6\u53d8\u5316\u3002<\/p>\n \uff08F\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4\u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u3002<\/p>\n \uff08G-I\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4\u5c0f\u9f20\u80bf\u7624\u4f53\u79ef\u53d8\u5316\uff0c\u6cbb\u7597\u7ed3\u675f\u65f6\u5c0f\u9f20\u79bb\u4f53\u80bf\u7624\u7167\u7247\u4ee5\u53ca\u80bf\u7624\u8d28\u91cf\u3002<\/p>\n \u56fe\u516d\u3001\u5149\u70ed\u6cbb\u7597\u540e\u5c0f\u9f20\u80bf\u7624\u5fae\u73af\u5883\u53d8\u5316<\/strong><\/p>\n PTT\u540e3\u5929\u5206\u79bb\u80bf\u7624\uff0c\u77f3\u8721\u5207\u7247\u8fdb\u884cDNA\u65ad\u88c2\uff08TUNEL\uff09\u3001Ki67\u3001CA9\u3001Iba1\u548cCD31\u7684\u514d\u75ab\u8367\u5149\u67d3\u8272\u3002<\/p>\n \uff08A\uff09\u80bf\u7624\u73af\u5883\u53d8\u5316\u7684\u5178\u578b\u5f71\u50cf\u5b66\u8868\u73b0\u3002<\/p>\n \uff08B-F\uff09\u4f5c\u4e3a\u53c2\u6570\u7c7b\u578b\u51fd\u6570\u7684\u7edf\u8ba1\u5206\u6790\u3002\uff08B\uff09TUNEL\u7684DNA\u65ad\u88c2\uff0c\uff08C\uff09Ki67\uff0c\uff08D\uff09CA9\uff0c\uff08E\uff09Iba1\u548c\uff08F\uff09CD31\u3002<\/p>\n \u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n \u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u65e8\u5728\u89e3\u51b3\u5f71\u54cd\u4e8c\u7ef4\u7eb3\u7c73\u6750\u6599\u4e34\u5e8a\u5e94\u7528\u7684\u5173\u952e\u95ee\u9898\uff0c\u5236\u9020\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u4e8c\u7ef4TeSe\u6a2a\u5411\u5f02\u8d28\u7ed3\u7eb3\u7c73\u6750\u6599\uff0c\u8be5\u6750\u6599\u5177\u6709\u51e0\u4e2a\u72ec\u7279\u7684\u7279\u5f81\uff1a\uff08i\uff09\u751f\u7269\u76f8\u5bb9\u6027\u597d\uff0c\uff08ii\uff09\u5f62\u6001\u5747\u5300\uff0c\uff08iii\uff09\u80bf\u7624\u4e2d\u76f8\u5bf9\u8f83\u9ad8\u7684\u84c4\u79ef\u91cf\uff0c\uff08iv\uff09\u9ad8\u5ea6\u7a33\u5b9a\uff0c\uff08v\uff09\u9ad8\u7684\u5149\u70ed\u8f6c\u6362\u6548\u7387\u3002\u8fd9\u79cd\u65e0\u6bd2\u7684TeSe\u7eb3\u7c73\u6750\u6599\u5728\u8377\u7624\u5c0f\u9f20\u4e2d\u7684\u5168\u8eab\u9012\u9001\u4ea7\u751f\u4e86\u60ca\u4eba\u7684\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u66b4\u9732\u4e8e\u5149\u7ebf\u4e0b\uff0cTeSe\u7eb3\u7c73\u9897\u7c92\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u51e0\u4e4e\u53ef\u4ee5\u5b8c\u5168\u6839\u9664\u80ba\u764c\u548c\u809d\u7ec6\u80de\u764c\u3002\u4e0e\u80bf\u7624\u6291\u5236\u4e00\u81f4\uff0cPTT\u6539\u53d8\u4e86\u80bf\u7624\u7684\u5fae\u200b\u200b\u73af\u5883\u5e76\u8bf1\u5bfc\u4e86\u5de8\u5927\u7684\u764c\u7ec6\u80de\u51cb\u4ea1\u3002\u603b\u4e4b\uff0c\u7ecf\u8fc7\u7814\u7a76\uff0c\u4f5c\u8005\u8ba4\u4e3a\u8be5\u7814\u7a76\u4e3a\u6297\u764c\u7eb3\u7c73\u6750\u6599\u7684\u4e34\u5e8a\u5e94\u7528\u63d0\u4f9b\u4e86\u5de8\u5927\u7684\u524d\u666f\u3002<\/p>\n \u6587\u732e\u94fe\u63a5\uff1aEradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions <\/a>(Sci Adv<\/em>, 2020<\/strong>, DOI: 10.1126\/sciadv.aay6825)<\/p>\n \u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n