{"id":200342,"date":"2020-04-25T06:55:55","date_gmt":"2020-04-24T22:55:55","guid":{"rendered":"\/\/m.iemloyee.com\/?p=200342"},"modified":"2020-04-24T21:56:20","modified_gmt":"2020-04-24T13:56:20","slug":"%e4%b8%8a%e4%ba%a4%e5%a4%a7acs-nano%ef%bc%9a%e9%9d%b6%e5%90%91%e6%80%a7%e7%ba%b3%e7%b1%b3%e9%80%92%e9%80%81%e7%b3%bb%e7%bb%9f%e6%94%bb%e5%85%8b%e7%b3%bb%e7%bb%9f%e6%80%a7%e7%ba%a2%e6%96%91%e7%8b%bc","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=200342","title":{"rendered":"\u4e0a\u4ea4\u5927ACS Nano\uff1a\u9776\u5411\u6027\u7eb3\u7c73\u9012\u9001\u7cfb\u7edf\u653b\u514b\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08Systematic Lupus Erythematosus\uff0cSLE\uff09\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u81f4\u6b7b\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u6548\u5e94\u5b50\/\u8c03\u8282\u6027T\u7ec6\u80de\u5931\u8861\u3002\u76ee\u524d\u5173\u4e8eSLE\u7684\u7597\u6cd5\u5927\u591a\u65e0\u6548\u6216\u5177\u6709\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002SLE\u75c5\u56e0\u590d\u6742\uff0c\u6548\u5e94\u6027\/\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u5931\u8861\u662fSLE \u53d1\u751f\u53d1\u5c55\u7684\u5173\u952e\u75c5\u56e0\u3002miRNA\u4f5c\u4e3a\u4e00\u79cd\u8d1f\u8c03\u63a7\u5206\u5b50\u53c2\u4e0e\u5305\u62ecT\u7ec6\u80de\u5728\u5185\u7684\u5927\u90e8\u5206\u514d\u75ab\u7ec6\u80de\u7684\u5206\u5316\u548c\u514d\u75ab\u5e94\u7b54\u7684\u5404\u4e2a\u73af\u8282\uff0c\u5176\u53ef\u8c03\u8282\u5927\u7ea690%\u7684\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0cmiRNA\u7684\u5931\u8c03\u4e0eSLE\u7684\u53d1\u75c5\u6709\u5173\u3002\u56e0\u6b64\uff0cmiRNA\u5728\u673a\u4f53\u4e2d\u5bf9\u514d\u75ab\u7ec6\u80de\u7684\u8c03\u8282\u4f5c\u7528\u662f SLE \u836f\u7269\u5f00\u53d1\u7684\u6781\u597d\u9776\u70b9\u3002\u4f46\u514d\u75ab\u539f\u6027\u548c\u9ad8\u5242\u91cf\u8981\u6c42\u963b\u788d\u4e86miRNA\u6cbb\u7597\u7684\u5e94\u7528\uff0c\u56e0\u6b64\uff0c\u5f00\u53d1\u5408\u9002\u7684\u8f7d\u4f53\u662f\u5728\u4f53\u5185\u5e94\u7528miRNA\u6cbb\u7597SLE\u7684\u524d\u63d0\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u6bb5\u53cb\u5bb9\u6559\u6388\u3001\u6c88\u5357\u6559\u6388\u548c\u5510\u5143\u5bb6\u526f\u6559\u6388<\/strong>\u8054\u5408\u5f00\u53d1\u4e86\u4e00\u79cd\u7eb3\u7c73\u9012\u9001\u7cfb\u7edf\uff08PEALmiR-125a<\/sub>\uff09\u9012\u9001miRNA\u81f3T\u7ec6\u80de\uff0c\u91cd\u5851\u6548\u5e94T\u7ec6\u80de\u548c\u8c03\u8282T\u7ec6\u80de\uff08Treg\uff09\u5e73\u8861\u6cbb\u7597\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3002\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0cPEALmiR-125a<\/sub> NPs\u53ef\u4ee5\u88ab\u4f18\u5148\u5bcc\u96c6\u5728\u813e\u810f\u4e2d\uff0c\u5e76\u6709\u6548\u5730\u5c06miR-125a\u8f6c\u67d3\u5230MRL\/lpr\u5c0f\u9f20\u7684T\u7ec6\u80de\u4e2d\u3002\u7136\u540e\uff0c\u4f5c\u8005\u7814\u7a76\u4e86PEALmiR-125a<\/sub> NPs\u6cbb\u7597SLE\u7684\u7597\u6548\uff0c\u53d1\u73b0\u6ce8\u5c04PEALmiR-125a<\/sub> NPs\u53ef\u4ee5\u901a\u8fc7\u6062\u590d\u6548\u5e94\/\u8c03\u8282\u6027T\u7ec6\u80de\u5e73\u8861\u6765\u51cf\u8f7bSLE\u7684\u53d1\u5c55\u3002\u6b64\u5916\uff0c\u4e0e\u975e\u7279\u5f02\u6027\u514d\u75ab\u514d\u75ab\u6291\u5236GC\u8bd5\u5242\u76f8\u6bd4\uff0cPEALmiR-125a<\/sub> NPs\u663e\u793a\u51fa\u6781\u597d\u7684\u5b89\u5168\u6027\u3002\u603b\u4f53\u800c\u8a00\uff0cPEALmiR-125a<\/sub> NPs\u4ee3\u8868\u4e86SLE\u6cbb\u7597\u7684\u4e00\u79cd\u6709\u524d\u9014\u7684\u7b56\u7565\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cMicroRNA-125a-Loaded Polymeric Nanoparticles Alleviate Systemic Lupus Erythematosus by Restoring Effector\/Regulatory T Cells Balance<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aACS Nano<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u7eb3\u7c73\u7c92\u5b50\u7684\u7a33\u5b9a\u6027\u4ee5\u53ca\u5bf9\u836f\u7269\u7684\u5305\u5c01\u53ca\u91ca\u653e<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09PEALmiNC<\/sub> NPs\u7684\u7c92\u5f84\u5206\u5e03\u548cTEM\u56fe\u50cf\u3002<\/p>\n

\uff08B\uff09PEALmiNC<\/sub> NPs\u7684\u8868\u9762\u7535\u52bf\u4e3a0.01 mV\u3002<\/p>\n

\uff08C-D\uff09\u57284 o<\/sup>C\u548c37 o<\/sup>C\u6761\u4ef6\u4e0b\u653e\u7f6e\u4e00\u5468PEALmiNC<\/sub> NPs\u7684\u7c92\u5f84\u548cPDI\u5206\u5e03\u3002<\/p>\n

\uff08E\uff09\u6e38\u79bbmiNC\u548cPEALmiNC<\/sub> NPs\u7684\u4f53\u5916\u91ca\u653e\u66f2\u7ebf\u3002<\/p>\n

\uff08F\uff09\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7528RNA\u9176\u5b75\u80b2\u7684\u6e38\u79bbmiRNA\u6216PEALmiNC<\/sub> NPs\uff0c\u7136\u540e\u901a\u8fc7\u743c\u8102\u7cd6\u51dd\u80f6\u7535\u6cf3\u68c0\u67e5miRNA\u6c34\u5e73\u3002<\/p>\n

\u56fe\u4e8c\u3001<\/strong>PEAL NPs<\/strong>\u5728\u6d3b\u5316<\/strong>T<\/strong>\u7ec6\u80de\u4e2d\u7684\u5438\u6536<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5206\u522b\u4e0ePBS\u3001\u6e38\u79bbcy5-miNC\u3001PEG-PLGAcy5-miNC<\/sub>\u548cPEALcy5-miNC<\/sub>\u5b75\u80b26\u5c0f\u65f6\u7684\u813e\u810fT\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\u3002<\/p>\n

\uff08B\uff09\uff08A\uff09\u4e2dcy5+<\/sup>\u7ec6\u80de\u7684\u542b\u91cf\u5bf9\u6bd4\u3002<\/p>\n

\uff08C\uff09\u5c06\u813e\u810f\u7ec6\u80de\u4e0ePBS\u3001\u6e38\u79bbcy5-miNC\u3001PEG-PLGAcy5-miNC<\/sub>\u548cPEALcy5-miNC<\/sub>\u5171\u5b75\u80b26\u5c0f\u65f6\u3002\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\u539f\u59cbT\u7ec6\u80de\u548c\u6548\u5e94T\u7ec6\u80de\u5185\u7684cy5+<\/sup>\u7ec6\u80de\u542b\u91cf\u3002<\/p>\n

\uff08D\uff09\uff08C\uff09\u4e2dcy5+<\/sup>\u7ec6\u80de\u7684\u542b\u91cf\u5bf9\u6bd4\u3002<\/p>\n

\uff08E\uff09\u5c06T\u7ec6\u80de\u9759\u606f\u6216\u6d3b\u531624\u5c0f\u65f6\uff0c\u7136\u540e\u4e0ePBS\u3001\u6e38\u79bbcy5-miNC\u3001PEG-PLGAcy5-miNC<\/sub>\u548cPEALcy5-miNC<\/sub>\u5171\u5b75\u80b26\u5c0f\u65f6\u3002\u5bf9\u9759\u606f\u6216\u6fc0\u6d3b\u7684T\u7ec6\u80de\u4e2dcy5+<\/sup>\u7ec6\u80de\u7fa4\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\u3002<\/p>\n

\uff08F\uff09\uff08E\uff09\u4e2dcy5+<\/sup>\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u3002<\/p>\n

\u56fe\u4e09\u3001<\/strong>PEALmiNC<\/sub> NPs<\/strong>\u5bf9<\/strong>Treg<\/strong>\u7684\u4f5c\u7528\u548c\u6291\u5236\u529f\u80fd<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5728\u57f9\u517b\u8fc7\u7a0b\u4e2d\uff0c\u7528\u6d82\u6709\u6297CD3\/CD28\u6297\u4f53\u7684\u5e73\u677f\u523a\u6fc0\u813e\u810fT\u7ec6\u80de\uff0c\u813e\u810fT\u7ec6\u80de\u4e0ePBS\u3001PEALmiR-125a<\/sub>\u6216\u6e38\u79bbMiR-125a\u5171\u5b75\u80b224\u5c0f\u65f6\u7684MiR-125a\u6c34\u5e73\u3002<\/p>\n

\uff08B\uff0cC\uff09\u7528PBS\u3001\u6e38\u79bbmiR-125a\u6216PEALmiR-125a<\/sub>\u5904\u74063\u5929\u7684T\u7ec6\u80de\uff0c\u5728CD3\/CD28\u6297\u4f53\u523a\u6fc0\u4e0bIFN-\u03b3\u548cSTAT3 mRNA\u7684\u8868\u8fbe\u6c34\u5e73\u3002<\/p>\n

\uff08D\uff09\u5c06\u813e\u810fT\u7ec6\u80de\u4e0eDex\u6216\u4e0d\u540c\u6d53\u5ea6PEAL\u6216PEALmiR-125a<\/sub>\u5171\u5b75\u80b224\u5c0f\u65f6\uff0c\u7528\u6d41\u5f0f\u7ec6\u80de\u4eea\u68c0\u6d4bT\u7ec6\u80de\u51cb\u4ea1\u7387\u3002<\/p>\n

\uff08E\uff09\u7528PBS\u3001\u6e38\u79bbmiR-125a\u3001PEALmiR-125a<\/sub>\u6216Dex\u5e73\u677f\u5305\u88ab\u6297CD3\/CD28\u6297\u4f53\u5b75\u80b23\u5929\u7684\u5206\u88c2\u7ec6\u80de\u767e\u5206\u6bd4\u3002<\/p>\n

\uff08F\uff09CD4+<\/sup> T\u7ec6\u80de\u4e0ePBS\u3001\u6e38\u79bbmiR-125a\u3001PEALmiR-125a<\/sub>\u6216Dex+TGF-\u03b2\u5171\u5b75\u80b2\u4e0d\u540c\u65f6\u95f4\u540e\uff0c\u7ec6\u80de\u5185\u7684Foxp3+<\/sup> Treg\u3002<\/p>\n

\uff08G\uff09Tregs\u7531PBS\u3001\u6e38\u79bbmiR-125a\u3001PEALmiR-125a<\/sub>\u6216Dex+TGF-\u03b2\u8bf1\u5bfc72\u5c0f\u65f6\u540e\uff0c\u5728\u677f\u5305\u88ab\u7684\u6297CD3\/CD28\u6297\u4f53\u4e0b\uff0c\u5c06Tag-it\u7d2b\u7f57\u5170\u6807\u8bb0\u7684\u5e38\u89c4T\u7ec6\u80de\u4e0e\u8bf1\u5bfc\u7684Treg\u4ee52\uff1a1\u7684\u6bd4\u7387\u5b75\u80b2\u4e0d\u540c\u7684\u65f6\u95f4\u70b9\u3002\u6d4b\u91cf\u4e86\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u5e38\u89c4T\u7ec6\u80de\u589e\u6b96\u3002<\/p>\n

\u56fe\u56db\u3001<\/strong>PEALmiNC<\/sub> NPs<\/strong>\u5728<\/strong>SLE<\/strong>\u6a21\u578b\u4e2d\u5bf9<\/strong>miR-125a<\/strong>\u7684\u6709\u6548\u9012\u9001<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5c06T\u7ec6\u80de\u4e0ePBS\uff0c\u6e38\u79bbcy5-miNC\u6216PEALcy5-miNC<\/sub>\u5171\u5b75\u80b26\u5c0f\u65f6\u540e\u7ec6\u80de\u4e2dcy5+<\/sup>\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\u3002<\/p>\n

\uff08B\uff09\uff08A\uff09\u4e2dcy5+<\/sup>\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u3002<\/p>\n

\uff08C\uff09\u6765\u81ea\u7528PEALcy7-miNC<\/sub> NPs\u6216\u6e38\u79bbcy7-miNC\u9759\u8109\u6ce8\u5c044\u5c0f\u65f6\u548c24\u5c0f\u65f6\u7684MRL\/MpJ\u5c0f\u9f20\u548cMRL\/lpr\u5c0f\u9f20\u7684\u5668\u5b98\u7684\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\uff08D\uff09\uff08C\uff09\u4e2d\u7684\u813e\u548c\u809dcy7\u7684MFI\u3002<\/p>\n

\uff08E\uff09\u7528PEALcy7-miNC<\/sub> NPs\u6216\u6e38\u79bbcy7-miNC\u9759\u8109\u6ce8\u5c0424\u5c0f\u65f6\u7684MRL\/MpJ\u548cMRL\/lpr\u5c0f\u9f20\u7684\u813e\u810fT\u7ec6\u80de\u4e2d\u7684cy5+<\/sup>T\u7ec6\u80de\u3002<\/p>\n

\uff08F\uff09\uff08E\uff09\u4e2dcy5+<\/sup>T\u7ec6\u80de\u7684\u7edf\u8ba1\u5206\u6790\u3002<\/p>\n

\u56fe\u4e94\u3001<\/strong>PEALmiR-125a<\/sub><\/strong>\u5bf9\u813e\u810f\u7ec6\u80de\u7a33\u6001\u7684\u5f71\u54cd<\/strong><\/p>\n

\"\"<\/p>\n

\u5728\u7b2c10\u300111\u300112\u5468\u65f6\uff0c\u5411MRL\/MpJ\u5c0f\u9f20\u9759\u8109\u6ce8\u5c04PBS\u3001PEALmiR-125a<\/sub> NPs\uff081.5 mg\/kg\uff09\u3001\u76f8\u540c\u5242\u91cf\u7684PEAL NPs\u3001Dex\uff081 mg\/kg\uff09\u6d4b\u91cf\u813e\u7ec6\u80de\u3002\uff08A-B\uff09\u813e\u810fCD4+<\/sup>\u548cCD8+<\/sup>T\u7ec6\u80de\u6570\u3002<\/p>\n

\uff08C\uff09CD4+<\/sup>T\u7ec6\u80de\u4e2dTreg\u7ec6\u80de\u7fa4\u7684\u6bd4\u4f8b\u3002<\/p>\n

\uff08D\uff09\u813e\u810f\u4e2dB\u7ec6\u80de\u6570\u76ee\u3002<\/p>\n

\uff08E-G\uff09\u663e\u793a\u813e\u810f\u5de8\u566c\u7ec6\u80de\u3001DC\u7ec6\u80de\u548c\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u7edd\u5bf9\u6570\u91cf\u3002<\/p>\n

\u56fe\u516d\u3001<\/strong>PEALmiR-125a<\/sub><\/strong>\u6539\u5584<\/strong>SLE<\/strong>\u5c0f\u9f20\u7684\u81ea\u8eab\u514d\u75ab\u6027<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u52a8\u7269\u5b9e\u9a8c\u65b9\u6848\uff1a\u5c0f\u9f20\u6bcf\u5468\u4e24\u6b21\uff08\u5206\u522b\u5728\u7b2c10\u300111\u300112\u548c13\u5468\uff09\u9759\u8109\u6ce8\u5c04PBS\uff0c\u6e38\u79bbmiR-125a\u3001PEALmiR-125a<\/sub>\u6216Dex\u3002<\/p>\n

\uff08B\uff09\u7528PBS\uff0c\u6e38\u79bbmiR-125a\u3001PEALmiR-125a<\/sub>\u6216Dex\u5904\u7406\u7684SLE\u5c0f\u9f20\u7684\u813e\u810f\u7684\u5bf9\u6bd4\u56fe\u50cf\u3002<\/p>\n

\uff08C\uff09\u4e0d\u540c\u5904\u7406\u5c0f\u9f20\u7684\u813e\u810f\u91cd\u91cf\u3002<\/p>\n

\uff08D\uff09\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u6d4b\u91cf\u5c3f\u86cb\u767d\u542b\u91cf\u3002<\/p>\n

\uff08E\uff09\u901a\u8fc7ELISA\u6d4b\u91cf\u7684\u8840\u6e05\u808c\u9150\u6c34\u5e73\u3002<\/p>\n

\uff08F\uff09SLE\u5c0f\u9f20\u7684\u76ae\u80a4\u635f\u4f24\u5bf9\u6bd4\u3002<\/p>\n

\u56fe\u4e03\u3001<\/strong>PEALmiR-125a<\/sub><\/strong>\u6cbb\u7597\u51cf\u5c11\u72fc\u75ae\u6027\u80be\u708e<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u80be\u810f\u5207\u7247\u7684H\uff06E\u67d3\u8272\u56fe\u50cf\u3002<\/p>\n

\uff08B-D\uff09\u80be\u5207\u7247\u7684IHC\u56fe\u50cf\u663e\u793a\u6297CD3\u3001\u6297IgG\u548c\u6297C3\u7684\u80be\u6c89\u79ef\u3002<\/p>\n

\uff08E\uff09\uff08A\uff09\u80be\u5c0f\u7403\u6027\u80be\u708e\u8bc4\u4f30\u3002<\/p>\n

\uff08F\uff09\uff08B\uff09\u4e2d\u6d78\u6da6\u6027CD3+<\/sup>T\u7ec6\u80de\u7684\u6570\u91cf\u3002<\/p>\n

\uff08G\uff09\uff08C\uff09\u4e2d\u80be\u810fIgG\u67d3\u8272\u7684\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n

\uff08H\uff09\uff08D\uff09\u4e2d\u80be\u810fC3\u67d3\u8272\u7684\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n

\u56fe\u516b\u3001<\/strong>PEALmiR-125a<\/sub><\/strong>\u9006\u8f6c<\/strong>SLE<\/strong>\u4e2d\u6548\u5e94<\/strong>\/<\/strong>\u8c03\u8282<\/strong>T<\/strong>\u7ec6\u80de\u7684\u5931\u8861<\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u6cbb\u75974\u5468\u540e\uff0c\u5404\u7ec4\u813e\u810fT\u7ec6\u80de\u7684\u6570\u91cf\u3002<\/p>\n

\uff08B\uff09\u5404\u7ec4CD4+<\/sup>T\u7ec6\u80de\u5185Treg\u7ec6\u80de\u7684\u9891\u7387\u3002<\/p>\n

\uff08C\uff09foxp3\u5728CD4+<\/sup>T\u7ec6\u80defoxp3+\u7fa4\u4e2d\u7684MFI\u3002<\/p>\n

\uff08D\uff09\u4e0d\u540c\u7ec4T\u7ec6\u80de\u5185Tfh<\/sub>\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u3002<\/p>\n

\uff08E\uff09\u8840\u6e05IL-21\u6c34\u5e73\u3002<\/p>\n

\uff08F\uff09\u8840\u6e05IL-17a\u6c34\u5e73\u3002<\/p>\n

\uff08G\uff09\u5c06MRL\/MpJ\u5c0f\u9f20\u7ecfTGF-\u03b2\u8bf1\u5bfc\u5206\u5316\u4e3aTregs\u7684\u5e7c\u7a1aT\u7ec6\u80de\u57f9\u517b72h\u540e\uff0c\u5728\u6709\u6216\u65e0IL-6\u7684\u6297CD3\/CD28\u6297\u4f53\u523a\u6fc0\u4e0b\uff0c\u4e0e\u6807\u8bb0\u4e3a\u7d2b\u7f57\u5170\u6807\u8bb0\u7684\u5e38\u89c4T\u7ec6\u80de\u5171\u57f9\u517b\uff0c\u5e76\u4e0ePBS\u3001\u6e38\u79bbmiR-125a\u6216PEALmiR-125a<\/sub>NPs\u5171\u57f9\u517b\u3002\u6807\u8bb0\u7d2b\u7f57\u5170\u67d3\u6599+\u7ec6\u80de\u8fdb\u884c\u95e8\u63a7\u548c\u589e\u6b96\u5206\u6790\u3002<\/p>\n

\uff08H\uff09\u813e\u810fB\u7ec6\u80de\u7684\u7edd\u5bf9\u6570\u76ee\u3002<\/p>\n

\uff08I\uff09\u5404\u7ec4\u813e\u810f\u5185\u6d46\u7ec6\u80de\u7edd\u5bf9\u6570\u3002<\/p>\n

\uff08J-K\uff09\u7eaf\u5316\u7684B\u7ec6\u80de\u88ab\u7d2b\u7f57\u5170\u6807\u8bb0\uff0c\u7136\u540e\u4e0ePBS\u3001\u6e38\u79bbmiR-125a\u6216PEALmiR-125a<\/sub>NPs\u5171\u5b75\u80b23\u5929\u3002B\u7ec6\u80de\u5206\u88c2\u767e\u5206\u7387\u548c\u4e0a\u6e05\u6db2IgG\u6c34\u5e73\u3002<\/p>\n

\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n

\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u6210\u529f\u5730\u6784\u5efa\u4e86PEALmiR-125a<\/sub>\u7eb3\u7c73\u7ed9\u836f\u7cfb\u7edf\uff0c\u5b9e\u9a8c\u8bc1\u660e\u8be5\u7eb3\u7c73\u7ed9\u836f\u7cfb\u7edf\u5177\u6709\u5f88\u9ad8\u7684\u751f\u7269\u5b89\u5168\u6027\u3002\u5b9e\u9a8c\u8868\u660e\uff0cPEALmiR-125a<\/sub> NPs\u53ef\u4f18\u5148\u5bcc\u96c6\u4e8e\u75c5\u7406\u6027\u813e\u810f\uff0c\u5e76\u5728SLE\u6a21\u578b\u4e2d\u6709\u6548\u5730\u5c06miR-125a\u5bfc\u5165\u81f4\u75c5\u6027\u813e\u810fT\u7ec6\u80de\u3002\u5728\u5168\u8eab\u7ed9\u836f4\u5468\u540e\uff0cPEALmiR-125a<\/sub> NPs\u7eb3\u7c73\u7c92\u663e\u8457\u51cf\u8f7bSLE\u5c0f\u9f20\u7684\u75c5\u75c7\u3002\u76f8\u53cd\uff0c\u76f8\u540c\u5242\u91cf\u7684\u6e38\u79bbmiR-125a\u5bf9SLE\u51e0\u4e4e\u6ca1\u6709\u6cbb\u7597\u4f5c\u7528\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660ePEAL\u7eb3\u7c73\u7ed9\u836f\u7cfb\u7edf\u5927\u5927\u63d0\u9ad8\u4e86miR-125a\u7684\u4f53\u5185\u6cbb\u7597\u6548\u7387\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8868\u660ePEALmiR-125a<\/sub> NPs\u53ef\u4ee5\u901a\u8fc7\u9006\u8f6c\u6548\u5e94\/\u8c03\u8282T\u7ec6\u80de\u7684\u5931\u8861\u6765\u6062\u590dSLE\u5c0f\u9f20\u7684\u514d\u75ab\u7a33\u6001\u3002\u6240\u4ee5\u7ed3\u679c\u663e\u793a\uff0cPEALmiR-125a<\/sub> NPs\u4e3aSLE\u7684\u57fa\u56e0\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u7b56\u7565\u3002\u6b64\u5916\uff0c\u8be5\u5236\u5242\u5728\u5176\u4ed6\u4ee5T\u7ec6\u80de\u4e3a\u4e3b\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aMicroRNA-125a-Loaded Polymeric Nanoparticles Alleviate Systemic Lupus Erythematosus by Restoring Effector\/Regulatory T Cells Balance <\/a>(ACS Nano<\/em>, 2020<\/strong>, DOI: 10.1021\/acsnano.9b09998)<\/p>\n

\u8bfe\u9898\u7ec4\u7b80\u4ecb\uff1a<\/strong><\/p>\n

\u6bb5\u53cb\u5bb9\u6559\u6388\u8bfe\u9898\u7ec4\u8fd1\u5e74\u6765\u4e3b\u8981\u81f4\u529b\u4e8e\u836f\u7269\u9012\u9001\u7cfb\u7edf\u4e0e\u8f6c\u5316\u533b\u5b66\u9886\u57df\u7684\u7814\u7a76\uff0c\u63a2\u7d22\u4e86\u591a\u79cd\u57fa\u4e8e\u7eb3\u7c73\u6280\u672f\u548c\u751f\u7269\u6750\u6599\u7684\u80bf\u7624\u6cbb\u7597\u65b0\u7b56\u7565\u3002\u5c06\u6784\u5efa\u7684\u7eb3\u7c73\u9012\u9001\u7cfb\u7edf\u5e94\u7528\u4e8e\u8111\u80f6\u8d28\u7624\u3001\u524d\u5217\u817a\u764c\u3001\u80f0\u817a\u764c\u3001\u809d\u764c\u3001\u80ba\u764c\u3001\u4e73\u817a\u764c\u4ee5\u53ca\u5375\u5de2\u764c\u7b49\u591a\u79cd\u8010\u836f\u6027\u80bf\u7624\u7684\u9776\u5411\u6cbb\u7597\u7814\u7a76\uff0c\u6709\u4e00\u7cfb\u5217\u539f\u521b\u6027\u7814\u7a76\u6210\u679c\u53d1\u8868\uff08ACS Nano 2016, 10, 11548; Advanced Functional Materials 2018, 28, 1706; Autophagy 2017, 13, 1176; Chemical Engineering Journal 2020, 383, 123230; Biomaterials 2019\uff0c222, 119442; Biomaterials 2014, 35, 760; Theranostics 2017, 7, 4424; Theranostics 2019, 9, 1047\uff09\u3002<\/p>\n

\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com<\/a><\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenvip\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011 \u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08Systematic Lupus Erythematosus\uff0cSLE\uff09\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u81f4\u6b7b\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u6548\u5e94\u5b50\/\u8c03\u8282\u6027T\u7ec6…<\/p>\n","protected":false},"author":1004,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[4362],"class_list":["post-200342","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-4362"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/200342"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1004"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=200342"}],"version-history":[{"count":3,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/200342\/revisions"}],"predecessor-version":[{"id":200578,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/200342\/revisions\/200578"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=200342"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=200342"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=200342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}