{"id":199882,"date":"2020-04-21T06:59:20","date_gmt":"2020-04-20T22:59:20","guid":{"rendered":"\/\/m.iemloyee.com\/?p=199882"},"modified":"2020-04-20T19:59:30","modified_gmt":"2020-04-20T11:59:30","slug":"acc-chem-res-%e7%bb%bc%e8%bf%b0%ef%bc%9a%e8%b6%85%e5%88%86%e5%ad%90%e6%b0%b4%e5%87%9d%e8%83%b6%e7%9a%84%e6%89%8b%e6%80%a7%e8%b0%83%e6%8e%a7%e5%8f%8a%e5%85%b6%e7%94%9f%e7%89%a9%e5%ad%a6%e6%95%88","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=199882","title":{"rendered":"Acc. Chem. Res.\u7efc\u8ff0\uff1a\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u7684\u624b\u6027\u8c03\u63a7\u53ca\u5176\u751f\u7269\u5b66\u6548\u5e94\u7814\u7a76\u7814\u7a76"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u624b\u6027\u73b0\u8c61\u666e\u904d\u5b58\u5728\u4e8e\u751f\u7269\u548c\u81ea\u7136\u754c\u7684\u5206\u5b50(\u5982L-\u6c28\u57fa\u9178\u548cD-\u7cd6)\u3001\u8d85\u5206\u5b50\u3001\u5fae\u7eb3\u7c73(\u5982DNA\u3001RNA\u548c\u86cb\u767d\u8d28)\u6c34\u5e73\uff0c\u4ee5\u53ca\u5b8f\u89c2\u7cfb\u7edf\uff08\u5982\u6d77\u87ba\u548c\u690d\u7269\uff09\u3002\u4ece\u8fd1\u534a\u4e2a\u4e16\u7eaa\u4ee5\u6765\uff0c\u5206\u5b50\u624b\u6027\u5728\u836f\u7269\u8bbe\u8ba1\u4e2d\u7684\u91cd\u8981\u6027\u5df2\u7ecf\u88ab\u610f\u8bc6\u5230\uff1a\u4e00\u79cd\u5bf9\u6620\u4f53\u5bf9\u75be\u75c5\u6cbb\u7597\u662f\u6709\u6548\u548c\u5b89\u5168\u7684\uff0c\u53e6\u4e00\u79cd\u5bf9\u6620\u4f53\u5219\u6709\u53ef\u80fd\u662f\u65e0\u6548\uff0c\u751a\u81f3\u6709\u6bd2\u7684\u3002\u56e0\u4e3a\u624b\u6027\u5206\u5b50\u7684\u8fd9\u4e9b\u751f\u7269\u5b66\u6548\u5e94\uff0c\u5206\u5b50\u624b\u6027\u4e00\u76f4\u88ab\u8ba4\u4e3a\u662f\u751f\u7269\u6750\u6599\u53d1\u5c55\u7684\u5173\u952e\u56e0\u7d20\u3002<\/p>\n

\u4e0e\u5206\u5b50\u624b\u6027\u76f8\u6bd4\uff0c\u8d85\u5206\u5b50\u624b\u6027\u7684\u91cd\u8981\u6027\u53ca\u5176\u6f5c\u5728\u7684\u751f\u7269\u529f\u80fd\u5c1a\u672a\u5f97\u5230\u5145\u5206\u63a2\u8ba8\u3002\u7136\u800c\uff0c\u7531\u5206\u5b50\u57fa\u5143\u4e0d\u5bf9\u79f0\u7a7a\u95f4\u6392\u5217\u800c\u4ea7\u751f\u7684\u8d85\u5206\u5b50\u624b\u6027(\u4f8b\u5982DNA\u4e2d\u7684\u53cc\u87ba\u65cb\u7ed3\u6784)\u5219\u5728\u751f\u7269\u4f53\u5185\u53c2\u4e0e\u4e86\u8bb8\u591a\u91cd\u8981\u751f\u7406\u8fc7\u7a0b\u3002\u53d7\u8fd9\u4e9b\u9ad8\u5ea6\u590d\u6742\u7684\u8d85\u5206\u5b50\u624b\u6027\u7ed3\u6784\u53ca\u5176\u76f8\u5e94\u7684\u751f\u7269\u5b66\u4e8b\u4ef6\u7684\u542f\u53d1\uff0c\u5316\u5b66\u3001\u6750\u6599\u79d1\u5b66\u548c\u751f\u7269\u5b66\u7684\u4e00\u4e2a\u6311\u6218\u548c\u6f5c\u5728\u7684\u7814\u7a76\u65b9\u5411\u662f\u6784\u5efa\u5177\u6709\u624b\u6027\u7ed3\u6784\u53ef\u8c03\u7684\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53\u3002\u7531\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53\u6784\u5efa\u7684\u6c34\u51dd\u80f6\u56e0\u5176\u7406\u5316\u6027\u80fd\u4e0e\u5929\u7136ECM\u5341\u5206\u7c7b\u4f3c\uff0c\u662f\u4e00\u7c7b\u5f88\u6709\u6f5c\u529b\u7684\u751f\u7269\u6750\u6599\u3002\u7279\u522b\u662f\uff0c\u4e0e\u4f20\u7edf\u805a\u5408\u7269\u6c34\u51dd\u80f6\u4e0d\u540c\uff0c\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u4e2d\u5206\u5b50\u57fa\u5143\u901a\u8fc7\u975e\u5171\u4ef7\u952e\uff08\u5982\u6c22\u952e\u3001\u03c0-\u03c0\u5806\u79ef\u3001\u8303\u5fb7\u534e\u529b\u6216\u758f\u6c34\u4f5c\u7528\uff09\u76f8\u4e92\u4f5c\u7528\uff0c\u7531\u4e8e\u975e\u5171\u4ef7\u7684\u5f62\u6210\u5177\u6709\u53ef\u9006\u6027\uff0c\u56e0\u6b64\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u5bf9\u5916\u573a\u523a\u6fc0(\u5982\u6e29\u5ea6\u3001\u6eb6\u5242\u3001pH\u3001\u9176\u548c\u5149)\u548c\u751f\u5316\u4fe1\u53f7\u6709\u5f88\u597d\u7684\u523a\u6fc0\u54cd\u5e94\uff0c\u5e76\u80fd\u4e3a\u7ec6\u80de\u751f\u957f\u63d0\u4f9b\u4e00\u4e2a\u52a8\u6001\u7684\u73af\u5883\u3002\u57fa\u4e8e\u6b64\uff0c\u7531\u624b\u6027\u7ec4\u88c5\u4f53\u6784\u7b51\u7684\u8d85\u5206\u5b50\u6c34\u51dd\u4e3a\u6a21\u62df\u751f\u7269\u7cfb\u7edf\u7684\u7ed3\u6784\u548c\u529f\u80fd\u63d0\u4f9b\u4e86\u4e00\u4e2a\u826f\u597d\u9009\u62e9\uff0c\u8fd9\u5bf9\u4e8e\u7406\u89e3\u8d85\u5206\u5b50\u624b\u6027\u5728\u751f\u7269\u5b66\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u5177\u6709\u5341\u5206\u91cd\u8981\u7684\u610f\u4e49\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u51af\u4f20\u826f\u6559\u6388\u8bfe\u9898\u7ec4<\/strong>\u5728Acc. Chem. Res<\/strong>\u671f\u520a\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cSupramolecular Hydrogels with Tunable Chirality for Promising Biomedical Applications<\/strong>\u201d\u7684\u81ea\u6211\u7efc\u8ff0\uff0c\u4ecb\u7ecd\u4e86\u8fd1\u5e74\u6765\u8bfe\u9898\u7ec4\u5728\u624b\u6027\u8d85\u5206\u5b50\u6c34\u51dd\u9886\u57df\u7684\u7814\u7a76\u8fdb\u5c55\u548c\u7ed3\u679c\uff0c\u5e76\u5bf9\u8be5\u9886\u57df\u53d1\u5c55\u505a\u51fa\u5c55\u671b\u3002\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u9996\u5148\u4ecb\u7ecd\u4e86\u4e0e\u8d85\u5206\u5b50\u624b\u6027\u6709\u5173\u7684\u57fa\u672c\u6982\u5ff5\u4ee5\u53ca\u8d85\u5206\u5b50\u624b\u6027\u5728\u751f\u7269\u7cfb\u7edf\u4e2d\u7684\u91cd\u8981\u6027\u3002\u63a5\u7740\u4ecb\u7ecd\u4e86\u5982\u4f55\u5229\u7528\u5916\u573a\u523a\u6fc0\uff08\u5982\u6eb6\u5242\uff0c\u6e29\u5ea6\uff0cpH\uff0c\u91d1\u5c5e\u79bb\u5b50\u7b49\uff09\u8c03\u63a7\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53\u624b\u6027\u7ed3\u6784\u3002\u7b2c\u4e09\u90e8\u5206\u4ecb\u7ecd\u4e86\u8d85\u5206\u5b50\u624b\u6027\u8bf1\u5bfc\u7684\u5404\u79cd\u751f\u7269\u5b66\u73b0\u8c61\uff0c\u4f8b\u5982\u7ec6\u80de\u7c98\u9644\uff0c\u589e\u6b96\uff0c\u5206\u5316\uff0c\u51cb\u4ea1\uff0c\u86cb\u767d\u8d28\u5438\u9644\uff0c\u836f\u7269\u9012\u9001\u548c\u6297\u83cc\u7c98\u9644\u7b49\u3002\u6700\u540e\u4ecb\u7ecd\u4e86\u8fd9\u4e2a\u5feb\u901f\u53d1\u5c55\u9886\u57df\u7684\u6311\u6218\u548c\u672a\u6765\u53d1\u5c55\u7684\u524d\u666f\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

1<\/strong>\u3001\u5f15\u8a00<\/strong><\/p>\n

\u56fe\u4e00\u3001\u7531\u5206\u5b50\u57fa\u5143\u7ec4\u88c5\u6784\u7b51\u7684\u624b\u6027\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u539f\u7406\u56fe<\/strong><\/p>\n

\"\"2<\/strong>\u3001\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u4e2d\u7684\u624b\u6027\u8c03\u63a7<\/strong><\/p>\n

2.1<\/strong>\u3001\u6eb6\u5242<\/strong><\/p>\n

\u56fe\u4e8c\u3001\u901a\u8fc7\u4e0d\u540c\u5916\u5e38\u523a\u6fc0\u7684\u8c03\u63a7\u8d85\u5206\u5b50\u624b\u6027\u7ed3\u6784\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"\uff08a\uff09\u6eb6\u5242\u8bf1\u5bfc\u7684\u8d85\u5206\u5b50\u624b\u6027\u53cd\u8f6c\uff1b<\/p>\n

\uff08b\uff09\u5355\u4e2a\u624b\u6027\u5206\u5b50\u81ea\u7ec4\u88c5\u6210\u87ba\u65cb\u7eb3\u7c73\u7ea4\u7ef4\uff0c\u5728\u6e29\u5ea6\u4ece90\u2103\u964d\u81f320\u2103\u65f6\u5f62\u6210\u624b\u6027\u6c34\u51dd\u80f6\uff1b<\/p>\n

\uff08c\uff09\u53f3\u624b(P)\u87ba\u65cb\u7ea4\u7ef4\u5f62\u6210\u4e8epH7.0\u4ee5\u4e0b\u7684\u6eb6\u6db2\u4e2d\uff0c\u540c\u65f6\uff0c\u5de6\u624b(M)\u87ba\u65cb\u7ea4\u7ef4\u5f62\u6210\u4e8epH7.0\u4ee5\u4e0a\u7684\u6eb6\u6db2\u4e2d\uff1b<\/p>\n

\uff08d\uff09\u4e0e\u4e0d\u540c\u91d1\u5c5e\u79bb\u5b50\u5171\u7ec4\u88c5\u7684L-\u6c28\u57fa\u9178\u884d\u751f\u7269(LPF\u548cLPPG)\u663e\u793a\u51fa\u4e0d\u540c\u7684\u624b\u6027\u7eb3\u7c73\u7ed3\u6784\u3002<\/p>\n

2.2<\/strong>\u3001\u6e29\u5ea6<\/strong><\/p>\n

2.3<\/strong>\u3001<\/strong>pH<\/strong>\u503c<\/strong><\/p>\n

2.4<\/strong>\u3001\u91d1\u5c5e\u79bb\u5b50<\/strong><\/p>\n

2.5<\/strong>\u3001\u5176\u5b83\u56e0\u7d20<\/strong><\/p>\n

3<\/strong>\u3001\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u7684\u751f\u7269\u533b\u5b66\u5e94\u7528<\/strong><\/p>\n

3.1<\/strong>\u3001\u7ec6\u80de\u7c98\u9644\u548c\u589e\u6b96<\/strong><\/p>\n

\u56fe\u4e09\u3001\u7528\u82ef\u4e19\u6c28\u9178\u57fa\u51dd\u80f6\u7684\u4e24\u4e2a\u5bf9\u6620\u4f53<\/strong>(LPFEG<\/strong>\u548c<\/strong>DPFEG)<\/strong>\u5236\u5907\u4e86\u7528\u4e8e\u4e09\u7ef4<\/strong>(3D)<\/strong>\u7ec6\u80de\u57f9\u517b\u7684\u624b\u6027\u6c34\u51dd\u80f6\u4f53\u7cfb<\/strong><\/p>\n

\"\"\uff08a\uff09\u624b\u6027\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u4e2d\u4e09\u7ef4\u7ec6\u80de\u57f9\u517b\u7684\u56fe\u89e3\uff1b<\/p>\n

\uff08b\uff09\u5de6\u67f1\uff1a\u57f9\u517b3\u5929\u540eL(D)PFEG\u6c34\u51dd\u80f6\u4e2dHUVECs\u7684\u8367\u5149\u663e\u5fae\u955c\u56fe\u50cf\u3002\u6d3b\u7ec6\u80de\u662f\u7eff\u8272\u7684\uff0c\u6b7b\u7ec6\u80de\u662f\u7ea2\u8272\u7684\u3002\u53f3\u67f1\uff1a\u624b\u6027\u6c34\u51dd\u80f6\u4e2d\u4e0d\u540c\u7ec6\u80de\u7c98\u9644\u548c\u589e\u6b96\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08c\uff09\u5728L(D)PFEG\u6c34\u51dd\u80f6\u4e2d\u57f9\u517bHUVECs\u7684\u7ec6\u80de\u589e\u6b96\u7edf\u8ba1\uff0c\u76f4\u5230\u7b2c9\u5929\uff1b<\/p>\n

\uff08d\uff09BA\u3001BE\u548cBP\u7684\u5206\u5b50\u7ed3\u6784\uff1b<\/p>\n

\uff08e\uff09\u5206\u5b50\u624b\u6027\u548c\u8d85\u5206\u5b50\u624b\u6027\u5bf9\u7ec6\u80de\u7c98\u9644\u7684\u534f\u540c\u5f71\u54cd\u4f5c\u7528\u3002<\/p>\n

3.2<\/strong>\u3001\u7ec6\u80de\u5206\u5316<\/strong><\/p>\n

\u56fe\u56db\u3001\u901a\u8fc7\u6df7\u5408\u7ec6\u80de\u60ac\u6db2\u548c<\/strong>L(D)PFEG<\/strong>\u51dd\u80f6\u57fa\u5143\u7684\u4e8c\u7532\u57fa\u4e9a\u781c<\/strong>(DMSO)<\/strong>\u6eb6\u6db2\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/strong>(MSCs)<\/strong>\u6ce8\u5165\u4e09\u7ef4\u6c34\u51dd\u80f6\u4e2d<\/strong><\/p>\n

\"\"\uff08a\uff09\u7eb3\u7c73\u7ea4\u7ef4\u624b\u6027\u7ed3\u6784\u8bf1\u5bfc\u5e72\u7ec6\u80de\u5206\u5316\u7684\u539f\u7406\u56fe\uff1b<\/p>\n

\uff08b\uff09RT-qPCR\u91cf\u5316\u8868\u660e\uff0c\u5728LPFEG\u6c34\u51dd\u80f6(\u7b80\u79f0L)\u4e2d\uff0c\u6210\u9aa8\u6807\u8bb0\u7269(RUNX2, OPN, \u548cBMP2)\u7684\u4e0a\u8c03\u6700\u5927\uff0c\u800c\u5728DPFEG\u6c34\u51dd\u80f6(\u7b80\u79f0D)\u4e2d\uff0c\uff08PPARG \u548cADN)\u4e0a\u8c03\u6700\u5927\uff1b<\/p>\n

\uff08c\uff09\u5177\u6709\u4ee3\u8868\u6027\u7684\u03bcCT\u56fe\u50cf\uff1aMSC\/\u6c34\u51dd\u80f6\u690d\u5165\u540e\u5927\u9f20\u9885\u7f3a\u635f\u4e2d\u7684\u9aa8\u518d\u751f\uff1b<\/p>\n

\uff08d\uff09\u65b0\u5f62\u6210\u9aa8\u7ec4\u7ec7\u7684\u603b\u4f53\u9aa8\u4f53\u79ef\u8bc4\u4ef7\uff1b<\/p>\n

\uff08e\uff09\u65b0\u5f62\u6210\u9aa8\u7ec4\u7ec7\u7684\u9aa8\u5bc6\u5ea6(BMD)\u8bc4\u4ef7\uff1b<\/p>\n

\uff08f\uff09RT-qPCR\u7ed3\u679c\u63d0\u793aItg\u03b15\u03b21\u7c98\u9644\u6291\u5236\u5bfc\u81f4FAK\u3001ERK\u548cYAP\u7684\u4e0b\u8c03\uff1b<\/p>\n

\uff08g\uff09\u7eb3\u7c73\u7ea4\u7ef4\u624b\u6027\u8bf1\u5bfc\u7684\u7ec6\u80de\u5206\u5316\u548c\u57fa\u56e0\u8868\u8fbe\u3002<\/p>\n

3.3<\/strong>\u3001\u7ec6\u80de\u51cb\u4ea1<\/strong><\/p>\n

\u56fe\u4e94\u3001\u7531<\/strong>L-<\/strong>\u6216<\/strong>D-<\/strong>\u80bd\u884d\u751f\u7269\u81ea\u7ec4\u88c5\u7684\u9176\u4fc3\u624b\u6027\u7eb3\u7c73\u7ea4\u7ef4\uff0c\u5177\u6709\u8bf1\u5bfc\u764c\u7ec6\u80de\u51cb\u4ea1\u7684\u80fd\u529b<\/strong><\/p>\n

\"\"\uff08a\uff09\u7ec4\u88c5\u57fa\u5143\u524d\u9a71\u4f53(1P)\u548c\u7ec4\u88c5\u57fa\u5143\u5355\u4f53\uff081\uff09\u7684\u5206\u5b50\u7ed3\u6784\uff1b<\/p>\n

\uff08b\uff09\u9176\u8bf1\u5bfc\u6784\u5efa\u7684\u7eb3\u7c73\u7ea4\u7ef4\u9776\u5411\u4f5c\u7528\u4e8e\u7ebf\u7c92\u4f53\u5e76\u89e6\u53d1\u764c\u7ec6\u80de\u51cb\u4ea1\u7684\u539f\u7406\u56fe\u3002<\/p>\n

3.4<\/strong>\u3001\u86cb\u767d\u8d28\u5438<\/strong>\u6536<\/strong><\/p>\n

\u56fe\u516d\u3001\u4f7f\u7528\u7ea4\u7ef4\u8fde\u63a5\u86cb\u767d<\/strong>(FN)<\/strong>\u4f5c\u4e3a\u86cb\u767d\u8d28\u6a21\u578b\u8fdb\u884c\u5206\u5b50\u52a8\u6001<\/strong>(MD)<\/strong>\u6a21\u62df<\/strong><\/p>\n

\"\"\uff08a\uff09L(D)PFEG \u548cFnIII9-10\u86cb\u767d\u7ed3\u5408\u7684\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\uff1b<\/p>\n

\uff08b\uff09\u5e73\u8861\u72b6\u6001\u4e0bL(D)PFEG \u548cFnIII9-10\u7684\u7ed3\u5408\u7ed3\u6784\uff1b<\/p>\n

\uff08c\uff09LPFEG\u4e0eFnIII9-10\u4e4b\u95f4\u7684\u7ed3\u5408\u80fd\u4f4e\u4e8eDPFEG\u4e0eFNIII9-10\u4e4b\u95f4\u7684\u7ed3\u5408\u80fd\uff1b<\/p>\n

\uff08d\uff09\u77f3\u82f1\u6676\u4f53\u5fae\u5929\u5e73(QCM)\u5b9e\u9a8c\u8868\u5f81\u4e86\u4eba\u8840\u6e05\u767d\u86cb\u767d(HSA)\u4e0eDPLG\u548cLPLG\u7ec4\u88c5\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff1b<\/p>\n

\uff08e\uff09HSA\u5728\u4e0d\u540c\u624b\u6027\u7684\u51dd\u80f6\u8868\u9762\u4e0a\u663e\u793a\u51fa\u4e0d\u540c\u7684\u86cb\u767d\u8d28\u7c98\u9644\u3002<\/p>\n

3.5<\/strong>\u3001\u6297\u83cc\u7c98\u9644<\/strong><\/p>\n

3.6<\/strong>\u3001\u836f\u7269\u91ca\u653e<\/strong><\/p>\n

\u56fe\u4e03\u3001\u5728\u4f53\u5185\u8868\u73b0\u51fa\u836f\u7269\u7684\u63a7\u5236\u91ca\u653e<\/strong><\/p>\n

\"\"\uff08a\uff09\u7531d-\u6c28\u57fa\u9178\uff08\u84dd\u8272\uff09\u548c\u7532\u6c27\u8418\u4e19\u9178(NPX\uff0c\u7ea2\u8272)\u7ec4\u6210\u7684\u51dd\u80f6\u57fa\u5143\u5316\u5b66\u7ed3\u6784\uff1b<\/p>\n

\uff08b\uff09(1) Npx-ff,(2) Npx-ffy, (3) Npx-ffk, (4) Npx-ffky, (5) ffk(Npx), and (6) ffk(Npx)y\u6c34\u51dd\u80f6\u5185\u90e8\u7684TEM\u56fe\u50cf\u3002<\/p>\n

3.7<\/strong>\u3001\u8d85\u5206\u5b50\u624b\u6027\u5f15\u8d77\u7684\u5706\u6781\u5316\u53d1\u5149\uff08<\/strong>CPL<\/strong>\uff09<\/strong><\/p>\n

\u56fe\u516b\u3001\u901a\u8fc7\u5171\u7ec4\u88c5\u6765\u8c03\u8282<\/strong>CPL<\/strong>\u7684\u624b\u6027<\/strong><\/p>\n

\"\"\uff08a\uff09\u57fa\u4e8eLPF\u548c\u9999\u8c46\u7d20\u884d\u751f\u7269(G)\u5171\u7ec4\u88c5\u7684\u5177\u6709CPL\u7279\u6027\u7684\u624b\u6027\u7ed3\u6784\uff0c\u53ef\u901a\u8fc7\u6539\u53d8\u9999\u8c46\u7d20\u884d\u751f\u7269\u6216\u5c06\u91d1\u5c5e\u79bb\u5b50\u52a0\u5165\u5171\u7ec4\u88c5\u6765\u8c03\u8282CPL\uff1b<\/p>\n

\uff08b\uff09LPF\/G1\u7684CPL\u5149\u8c31(\u6fc0\u53d1\u6ce2\u957f\uff1a320nm)\uff1b<\/p>\n

\uff08c\uff09LPF\u548c1NA\/2\/NA\u5171\u7ec4\u88c5\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08d\uff09LPF-1NA\/2NA\u7684CPL\u5149\u8c31(\u6fc0\u53d1\u6ce2\u957f\uff1a325nm)\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u5c3d\u7ba1\u624b\u6027\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\uff0c\u4f46\u4ecd\u6709\u4e00\u4e9b\u6311\u6218\u6709\u5f85\u89e3\u51b3\u3002\u9996\u5148\uff0c\u8d85\u5206\u5b50\u51dd\u80f6\u57fa\u5143\u7684\u5206\u5b50\u8bbe\u8ba1\u8fd8\u5904\u4e8e\u65e9\u671f\u9636\u6bb5\uff0c\u56e0\u4e3a\u624b\u6027\u7ec4\u88c5\u7684\u673a\u7406\u5c1a\u672a\u6e05\u695a\u5730\u63ed\u793a\uff0c\u5f88\u96be\u51c6\u786e\u9884\u6d4b\u5206\u5b50\u7684\u7ec4\u88c5\u6a21\u5f0f\u548c\u8d85\u5206\u5b50\u7ed3\u6784\u7684\u624b\u6027\u3002\u7279\u522b\u662f\uff0c\u5728\u539f\u59cb\u51dd\u80f6\u4e0a\u4fee\u9970\u751f\u7269\u6d3b\u6027\u57fa\u56e2\uff0c\u5f80\u5f80\u6270\u4e71\u539f\u6709\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u5e73\u8861\uff0c\u5bfc\u81f4\u8d85\u5206\u5b50\u7ec4\u88c5\u7ed3\u6784\u7684\u89e3\u4f53\u3002\u4e3a\u4e86\u66f4\u597d\u5730\u63a2\u7d22\u624b\u6027\u6c34\u51dd\u80f6\uff0c\u5229\u7528\u5206\u5b50\u52a8\u529b\u5b66(MD)\u6a21\u62df\u548c\u65f6\u95f4\u4f9d\u8d56\u5bc6\u5ea6\u6cdb\u51fd\u7406\u8bba(TDDFT)\u8ba1\u7b97\u9884\u6d4b\u7ec4\u88c5\u4f53\u7684\u8d85\u5206\u5b50\u624b\u6027\u662f\u4e00\u4e2a\u5f88\u6709\u524d\u9014\u7684\u65b9\u5411\u3002\u5176\u4e2d\uff0c\u5bf9\u8d85\u87ba\u65cb\u7ed3\u6784\u7684\u9884\u6d4b\u66f4\u5177\u6311\u6218\u6027\uff0c\u56e0\u4e3a\u8d85\u87ba\u65cb\u7684\u5f62\u6210\u662f\u66f4\u4e3a\u590d\u6742\uff0c\u5305\u62ec\u4e00\u7ef4(1D)\u624b\u6027\u7ea4\u7ef4\u7684\u7ec4\u88c5\u548c\u4ece\u4f4e\u7ea7\u7ed3\u6784\u5230\u9ad8\u9636\u87ba\u65cb\u7ed3\u6784\u7684\u8f6c\u53d8\u3002\u5176\u6b21\uff0c\u8f83\u5f31\u7684\u529b\u5b66\u6027\u80fd\u662f\u624b\u6027\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u9700\u8981\u89e3\u51b3\u7684\u53e6\u4e00\u4e2a\u5173\u952e\u95ee\u9898\uff0c\u8fd9\u9650\u5236\u4e86\u5b83\u4eec\u7684\u8fdb\u4e00\u6b65\u5b9e\u9645\u5e94\u7528\uff08\u4f8b\u5982\u6ce8\u5c04\u7ec4\u7ec7\u518d\u751f\u3001\u6a21\u62df\u8f6f\u7ec4\u7ec7\u548c\u4f53\u5916\u957f\u671f\u7ec6\u80de\u57f9\u517b\uff09\u3002\u6839\u636e\u9700\u8981\u8c03\u6574\u8fd9\u4e9b\u624b\u6027\u6c34\u51dd\u80f6\u7684\u529b\u5b66\u6027\u80fd\u548c\u964d\u89e3\u65f6\u95f4\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002\u6b64\u5916\uff0c\u5c06\u7ec6\u80de\u5c01\u88c5\u5230\u4e09\u7ef4\u624b\u6027\u6c34\u51dd\u80f6\u4e2d\u8fdb\u884c\u4e09\u7ef4\u7ec6\u80de\u57f9\u517b\u4ecd\u7136\u662f\u4e00\u4e2a\u6311\u6218\u3002\u867d\u7136\u4e00\u4e9b\u5206\u5b50\u53ef\u4ee5\u5728\u8d85\u5206\u5b50\u5c3a\u5ea6\u4e0a\u81ea\u7ec4\u88c5\u6210\u624b\u6027\u7ea4\u7ef4\uff0c\u4f46\u8981\u5f62\u6210\u7531\u624b\u6027\u7ea4\u7ef4\u652f\u67b6\u7ec4\u6210\u7684\u5b8f\u89c2\u624b\u6027\u6c34\u51dd\u80f6\u4ecd\u8f83\u4e3a\u56f0\u96be\u3002<\/p>\n

\u8fdb\u4e00\u6b65\u7684\u53d1\u5c55\u4e0d\u4ec5\u9700\u8981\u7740\u773c\u4e0e\u624b\u6027\u6c34\u51dd\u80f6\u7684\u6784\u7b51\uff0c\u8fd8\u9700\u8981\u5173\u6ce8\u624b\u6027\u7ed3\u6784\u7684\u539f\u4f4d\u8c03\u63a7\uff0c\u8fd9\u4e3a\u52a8\u6001\u7814\u7a76\u7ec6\u80de\u5916\u624b\u6027\u5fae\u73af\u5883\u7684\u751f\u7269\u5b66\u6548\u5e94\u63d0\u4f9b\u4e86\u4e00\u79cd\u53ef\u80fd\u7684\u9014\u5f84\u3002\u5b83\u53ef\u4ee5\u63ed\u793a\u8d85\u5206\u5b50\u87ba\u65cb\u7ed3\u6784(\u4f8b\u5982\uff0c\u53cc\u87ba\u65cbDNA\u548c\u03b1-\u87ba\u65cb)\u5728\u751f\u547d\u7cfb\u7edf\u4e2d\u7684\u751f\u7406\u529f\u80fd\u3002\u624b\u6027\u6548\u5e94\u662f\u751f\u7269\u7cfb\u7edf\u7684\u57fa\u7840\uff0c\u56e0\u6b64\u8d85\u5206\u5b50\u624b\u6027\u6c34\u51dd\u80f6\u53d1\u5c55\u5c06\u4e3a\u624b\u6027\u751f\u7269\u6750\u6599\u5728\u7ec6\u80de\u57f9\u517b\u3001\u7ec4\u7ec7\u5de5\u7a0b\u548c\u518d\u751f\u533b\u5b66\uff08\u5982\u5e72\u7ec6\u80de\u5b9a\u5411\u5206\u5316\uff09\u4e2d\u7684\u5e94\u7528\u5f00\u8f9f\u65b0\u7684\u673a\u4f1a\u3002<\/p>\n

\u8be5\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005\u4e3a\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u52a9\u7406\u6559\u6388\u7aa6\u6653\u79cb<\/strong>\uff0c\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u4e3a\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u535a\u58eb\u751fNabila Mehwish<\/strong>\u3002\u51af\u4f20\u826f\u6559\u6388<\/strong>\u4e3a\u901a\u8baf\u4f5c\u8005\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66<\/strong>\u4e3a\u8bba\u6587\u552f\u4e00\u5355\u4f4d\u3002\uff08\u51af\u4f20\u826f\u6559\u6388\u8bfe\u9898\u7ec4\u957f\u671f\u4ece\u4e8b\u624b\u6027\u6c34\u51dd\u80f6\u7684\u6784\u7b51\u3001\u8c03\u63a7\u53ca\u751f\u7269\u5b66\u6548\u5e94\u7814\u7a76\uff0c\u53d1\u8868\u7684\u76f8\u5173\u8bba\u6587\u6709\uff1aAngew. Chem. Int. Ed.<\/em> 2014<\/strong>, 53, 7789.; ACS Nano<\/em> 2015<\/strong>, 9, 10664,; Angew. Chem. Int.<\/em> 2016<\/strong>, 55, 2411.;Chem. Sci.<\/em> 2017<\/strong>, 8, 1769.; Adv. Mater.<\/em> 2017<\/strong>, 29, 1604062.; Angew. Chem. Int. Ed.<\/em> 2018<\/strong>, 57, 5655.; Angew. Chem. Int. Ed.<\/em> 2018<\/strong>, 57, 6475.;Chem. Eur. J.<\/em> 2018<\/strong>, 24, 1509.; Adv. Mater.<\/em> 2019<\/strong>, 31, 1900582.;ACS Nano<\/em> 2019<\/strong>, 13, 7281.;ACS Appl. Mater. Interfaces<\/em> 2019<\/strong>, 11, 38568. Nanoscale<\/em> 2019<\/strong>, 11, 14210.\u7b49\uff09\u00a0<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aSupramolecular Hydrogels with Tunable Chirality for Promising Biomedical Applications<\/a>\uff08Acc. Chem. Res.<\/em> 2020<\/strong>, DOI:https:\/\/doi.org\/10.1021\/acs.accounts.0c00012\uff09<\/p>\n

\u672c\u6587\u7531\u6211\u4ea6\u662f\u884c\u4eba\u7f16\u8bd1\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/a><\/p>\n

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