{"id":199630,"date":"2020-04-17T06:22:35","date_gmt":"2020-04-16T22:22:35","guid":{"rendered":"\/\/m.iemloyee.com\/?p=199630"},"modified":"2020-04-16T18:23:02","modified_gmt":"2020-04-16T10:23:02","slug":"%e4%b8%ad%e7%a7%91%e9%99%a2%e9%95%bf%e6%98%a5%e5%ba%94%e5%8c%96%e6%89%80adv-mater-%ef%bc%9a%e7%bb%8f%e8%bf%87%e5%b7%a5%e7%a8%8b%e6%94%b9%e9%80%a0%e7%9a%84%e8%bf%91%e7%ba%a2%e5%a4%96%e8%8d%a7%e5%85%89","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=199630","title":{"rendered":"\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u5316\u6240Adv. Mater.\uff1a\u7ecf\u8fc7\u5de5\u7a0b\u6539\u9020\u7684\u8fd1\u7ea2\u5916\u8367\u5149\u86cb\u767d\u7ec4\u4ef6\u7528\u4e8e\u751f\u7269\u6210\u50cf\u548c\u6cbb\u7597"},"content":{"rendered":"
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\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n \u4e2d\u79d1\u9662\u957f\u6625\u5e94\u5316\u6240<\/strong>\u5c55\u793a\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u660e\u786e\u5b9a\u4e49\u7684mIFP\u7eb3\u7c73\u7ec4\u88c5\uff0c\u5176\u7531\u5e26\u6b63\u7535\u7684mIFP\u5171\u8f6d\u7269\u548c\u9634\u79bb\u5b50\u7fa7\u57fa\u672b\u7aef\u5c01\u7aef\u7684\u805a\u4e59\u4e8c\u9187\uff08PEG-COO-\uff09\u94fe\u7684\u9759\u7535\u7edc\u5408\u9a71\u52a8\u3002\u6240\u5f97\u7684\u86cb\u767d\u8d28\u7eb3\u7c73\u9897\u7c92\u5177\u6709\u51fa\u8272\u7684\u8fd1\u7ea2\u5916\u53d1\u5c04\u548c\u5149\u7a33\u5b9a\u6027\uff0c\u9ad8\u7ec6\u80de\u6e17\u900f\u6027\uff0c\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u5e76\u663e\u7740\u6539\u5584\u4e86\u8840\u6db2\u5faa\u73af\u65f6\u95f4\u3002\u901a\u8fc7\u5355\u6b21\u9759\u8109\u5185\u6ce8\u5c04\u5373\u53ef\u5728\u80bf\u7624\u90e8\u4f4d\u83b7\u5f97\u7a33\u5b9a\u4e14\u957f\u671f\u7684\u6210\u50cf\u7279\u6027\uff0c\u8fd9\u8fdc\u8fdc\u4f18\u4e8e\u8fc4\u4eca\u4e3a\u6b62\u62a5\u9053\u7684\u5176\u4ed6FP\u3002\u6709\u8da3\u7684\u662f\uff0cmIFP\u7ec4\u4ef6\u6709\u6548\u5730\u79ef\u805a\u5728\u5c0f\u9f20\u809d\u810f\u7684\u8f6c\u79fb\u6027\u80bf\u7624\u7ed3\u8282\u4e2d\uff0c\u8bc1\u5b9e\u4e86\u5b83\u4eec\u7684\u88ab\u52a8\u7279\u5f02\u6027\u9776\u5411\u80fd\u529b\u3002\u6b64\u5916\uff0c\u53d1\u73b0\u5def\u57fa\u94fe\u9709\u83cc\u7d20\u7684\u758f\u6c34\u6297\u80bf\u7624\u6297\u751f\u7d20\u88ab\u6709\u6548\u5730\u5305\u5c01\u5728\u86cb\u767d\u8d28\u7eb3\u7c73\u805a\u96c6\u4f53\u4e2d\uff0c\u5e76\u4e14\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u5b9e\u73b0\u4e86\u6709\u6548\u7684\u80bf\u7624\u6cbb\u7597\u3002\u56e0\u6b64\uff0c\u57fa\u4e8emIFP\u7684\u7ec4\u4ef6\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u65b0\u7684\u673a\u4f1a\u6765\u63a2\u7d22\u751f\u7269\u6210\u50cf\u548c\u51c6\u5206\u6bb5\u6cbb\u7597\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u5e94\u7528\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201c<\/strong>Engineered Near-Infrared Fluorescent Protein Assemblies for Robust Bioimaging and Therapeutic Applications<\/strong>\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Mater.<\/strong>\u4e0a<\/strong>\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n \u56fe<\/strong>1.<\/strong>mIFP-K72-PEG\u7eb3\u7c73\u7ec4\u4ef6\u7684\u5408\u6210\u4e0e\u8868\u5f81<\/p>\n A\uff09\u5236\u9020mIFP-K72-PEG\u7ec4\u4ef6\u7684\u793a\u610f\u56fe<\/p>\n B\uff09mIFP-K72-PEG\u7684TEM\u56fe\u50cf\u548c\u5c3a\u5bf8\u5206\u5e03<\/p>\n C\uff09mIFP-K72\u548cmIFP-K72-PEG\u7684\u53d1\u5c04\u5149\u8c31\uff08\u03bbex= 680 nm\uff09<\/p>\n D,E\uff09\u8840\u6db2\u548cPBS\u7f13\u51b2\u6db2\u4e2d\u7684\u8367\u5149mIFP-K72-PEG\u590d\u5408\u7269\u7684\u56fe\u50cf<\/p>\n \u56fe<\/strong>2.<\/strong>\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7684\u4f53\u5185\u548c\u4f53\u5916\u6210\u50cf<\/strong><\/p>\n A,B\uff09\u65bd\u7528GFP-K72-PEG\u6216mIFP-K72-PEG\u540e\uff0c\u53f3\u540e\u817f\u6709\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7269\u7684\u5c0f\u9f20\u4f53\u5185NIR\u8367\u5149\u6210\u50cf<\/p>\n C\uff09\u4f53\u5185NIR\u8367\u5149\u6210\u50cf\u7528\u4e8e\u5728\u6ce8\u5c04mIFP-K72-PEG\u540e\u66f4\u65e9\u5730\u68c0\u6d4b\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7269<\/p>\n D,E\uff09\u5207\u9664\u7684\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7269\u7684\u660e\u573a\u548cNIR\u8367\u5149\u6210\u50cf<\/p>\n \u56fe<\/strong>3.<\/strong>\u4f53\u5185\u548c\u4f53\u5916\u6210\u50cf\u7684\u8f6c\u79fb\u6027\u80bf\u7624\u7ed3\u8282<\/strong><\/p>\n A\uff09\u5bf9\u5c0f\u9f20\u8f6c\u79fb\u6027\u80bf\u7624\u7ed3\u8282\u6210\u50cf\u7684\u793a\u610f\u56fe<\/p>\n B\uff09\u6ce8\u5c04mIFP-K72-PEG\u540e\uff0c\u809d\u810f\u4e2d\u6709\u8f6c\u79fb\u6027\u80bf\u7624\u7ed3\u8282\u7684\u5c0f\u9f20\u4f53\u5185NIR\u8367\u5149\u6210\u50cf<\/p>\n C\uff09\u6765\u81ea\u4e0d\u540c\u7ec4\u7684\u5c0f\u9f20\u7ec4\u7ec7\u7684\u4f53\u5916\u6210\u50cf<\/p>\n \u56fe<\/strong>4.TSR<\/strong>\u5305\u88f9\u7684<\/strong>mIFP-K72-PEG<\/strong>\u7eb3\u7c73\u9897\u7c92\u7684\u6297\u80bf\u7624\u4f5c\u7528\u7814\u7a76<\/strong><\/p>\n A\uff09\u5728mIFP-K72-PEG\u7eb3\u7c73\u9897\u7c92\u4e2d\u7684TSR\u5c01\u88c5\u793a\u610f\u56fe<\/p>\n B\uff09TSR\u5c01\u88c5\u7684mIFP-K72-PEG\u7eb3\u7c73\u7c92\u5b50\u7684TEM\u56fe\u50cf\u548c\u5c3a\u5bf8\u5206\u5e03<\/p>\n C\uff09mIFP-K72-PEG\u7eb3\u7c73\u9897\u7c92\u4e2dTSR\u7684\u91ca\u653e\u901f\u7387<\/p>\n D\uff09\u7528TSR\u5c01\u88c5\u7684mIFP-K72-PEG\uff0c\u539f\u59cbTSR\uff0cPEG-TSR\u548cPBS\u6cbb\u7597\u540e\u53f3\u540e\u817f\u6709\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7269\u7684\u5c0f\u9f20\u7684\u7167\u7247<\/p>\n E\uff09\u6bcf\u7ec4\u6cbb\u7597\u7684\u80bf\u7624\u4f53\u79ef\u7684\u8c03\u67e5<\/p>\n F\uff09\u6cbb\u759721\u5929\u540e\u5904\u6b7b\u5c0f\u9f20\uff0c\u5206\u79bb\u6240\u6709\u80bf\u7624\u5e76\u6355\u83b7\u5176\u5927\u5c0f\u548c\u5f62\u6001<\/p>\n \u3010\u603b\u7ed3\u3011<\/strong><\/p>\n \u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u901a\u8fc7\u7ec4\u88c5\u5e26\u6b63\u7535\u7684mIFP\u5171\u8f6d\u7269\u548c\u5e26\u8d1f\u7535\u7684PEG-COO-\u94fe\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684NIR FPs\u7eb3\u7c73\u9897\u7c92\u3002\u5f3a\u5927\u7684\u86cb\u767d\u8d28\u7ec4\u4ef6\u63d0\u4f9b\u4e86\u8bf1\u4eba\u7684\u529f\u80fd\uff1a1\uff09\u5728\u5149\u7597\u7a97\u5185\u7684\u8fd1\u7ea2\u5916\u6fc0\u53d1\u548c\u53d1\u5c04\uff1b 2\uff09\u9ad8\u7ec6\u80de\u6e17\u900f\u6027\uff1b 3\uff09\u7ec6\u80de\u6bd2\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\u53ef\u5ffd\u7565\u4e0d\u8ba1\uff1b 4\uff09\u901a\u8fc7\u76f4\u63a5\u5916\u6e90\u6ce8\u5c04\u8fdb\u884c\u957f\u671f\u7a33\u5b9a\u7684\u4f53\u5185\u6210\u50cf\u3002\u8fd9\u4e9b\u7279\u6027\u4e0e\u4f20\u7edf\u7684\u6210\u50cf\u8bd5\u5242\u5b8c\u5168\u4e0d\u540c\uff0c\u5e76\u4e14\u514b\u670d\u4e86\u4f9d\u9760\u57fa\u56e0\u8f6c\u67d3\u548c\u5feb\u901f\u8367\u5149\u8870\u51cf\u7684FP\u751f\u7269\u6210\u50cf\u7684\u5c40\u9650\u6027\u3002\u8fd9\u4e2a\u7b56\u7565\u5df2\u6210\u529f\u7528\u4e8e\u4f53\u5185\u8ffd\u8e2a\u76ae\u4e0b\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u548c\u5b9a\u4f4d\u6df1\u5904\u7684\u8f6c\u79fb\u6027\u80bf\u7624\u7ed3\u8282\u3002\u53e6\u5916\uff0c\u8fd9\u4e9b\u7c7b\u578b\u7684\u86cb\u767d\u8d28\u7ec4\u88c5\u4f53\u88ab\u7528\u4f5c\u6cbb\u7597\u8bca\u65ad\u7eb3\u7c73\u8f7d\u4f53\u4ee5\u6709\u6548\u5730\u5305\u5c01\u548c\u9012\u9001\u758f\u6c34\u6027\u6297\u80bf\u7624\u836f\u7269\u3002\u7531\u4e8e\u8fd9\u7c7b\u86cb\u767d\u8d28\u7eb3\u7c73\u6750\u6599\u7684\u6df1\u5c42\u6e17\u900f\u6027\uff0c\u5149\u7a33\u5b9a\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u5b83\u4eec\u4e3a\u751f\u7269\u533b\u5b66\u8bca\u65ad\u548c\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u673a\u4f1a\u3002\u6b64\u5916\uff0c\u5728\u8fd9\u79cd\u7b56\u7565\u7684\u542f\u53d1\u4e0b\uff0c\u53ef\u4ee5\u901a\u8fc7\u9057\u4f20\u878d\u5408\u5176\u4ed6\u529f\u80fd\u86cb\u767d\u4ee5\u7528\u4e8e\u533b\u5b66\u5e94\u7528\uff0c\u8f7b\u677e\u5236\u9020\u5404\u79cd\u57fa\u4e8e\u86cb\u767d\u8d28\u7684\u7eb3\u7c73\u6750\u6599\u3002<\/p>\n \u6587\u732e\u94fe\u63a5<\/strong>\uff1aEngineered Near-Infrared Fluorescent Protein Assemblies for Robust Bioimaging and Therapeutic Applications<\/strong>. Adv. Mater., <\/em>2020<\/strong>, DOI: 10.1002\/adma.202000964.<\/p>\n \u672c\u6587\u7531tt\u4f9b\u7a3f\u3002\u00a0<\/p>\n \u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n \u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenvip\u3002\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":" \u3010\u5f15\u8a00\u3011 \u8fd1\u7ea2\u5916\uff08NIR\uff09\u8367\u5149\u6210\u50cf\u662f\u4e00\u4e2a\u4e0d\u65ad\u53d1\u5c55\u7684\u9886\u57df\uff0c\u53ef\u5b9e\u73b0\u751f\u7269\u533b\u5b66\u4e2d\u7684\u9ad8\u5206\u8fa8\u7387\u6210\u50cf\u548c\u8bca\u65ad\u3002\u7531\u4e8e\u51cf\u5c11\u4e86\u5149\u5b50\u6563\u5c04\u548c\u6700\u5c0f\u7684\u7ec4\u7ec7\u5438\u6536\uff0cNIR\u7a97\u53e3\uff08700-1700 …<\/p>\n","protected":false},"author":7336,"featured_media":199631,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[33],"class_list":["post-199630","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-nano"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/199630"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=199630"}],"version-history":[{"count":2,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/199630\/revisions"}],"predecessor-version":[{"id":200071,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/199630\/revisions\/200071"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/199631"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=199630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=199630"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=199630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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