{"id":198806,"date":"2020-03-29T06:12:33","date_gmt":"2020-03-28T22:12:33","guid":{"rendered":"\/\/m.iemloyee.com\/?p=198806"},"modified":"2020-03-28T20:13:04","modified_gmt":"2020-03-28T12:13:04","slug":"%e5%8d%97%e5%bc%80%e5%a4%a7%e5%ad%a6%e9%83%ad%e6%9c%af%e6%b6%9b%e5%92%8c%e5%9b%bd%e5%ae%b6%e7%ba%b3%e7%b1%b3%e4%b8%ad%e5%bf%83%e6%a2%81%e5%85%b4%e6%9d%b0nano-lett-%ef%bc%9a%e6%a8%a1%e5%9d%97%e5%8c%96","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=198806","title":{"rendered":"\u5357\u5f00\u5927\u5b66\u90ed\u672f\u6d9b\u548c\u56fd\u5bb6\u7eb3\u7c73\u4e2d\u5fc3\u6881\u5174\u6770Nano Lett.\uff1a\u6a21\u5757\u5316\u7684\u9178\u54cd\u5e94\u5730\u585e\u7c73\u677e\u7f29\u916e\u524d\u836f\u7eb3\u7c73\u836f\u7269\u63d0\u9ad8\u6297\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7597\u6548\u5e76\u51cf\u5c11\u526f\u4f5c\u7528"},"content":{"rendered":"<p>\u3010<strong>\u5f15\u8a00<\/strong>\u3011<\/p>\n<p>\u7eb3\u7c73\u7ed3\u6784\u4f5c\u4e3a\u5177\u6709\u72ec\u7279\u4f18\u52bf\u7684\u65b0\u578b\u836f\u7269\u8f93\u9001\u7cfb\u7edf\uff0c\u88ab\u5e7f\u6cdb\u7528\u4e8e\u6cbb\u7597\u4e0d\u540c\u75be\u75c5\u7684\u836f\u7269\u5f00\u53d1\u4e2d\u3002\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u4e2d\uff0c\u901a\u8fc7\u89e3\u51b3\u6eb6\u89e3\u6027\u95ee\u9898\u548c\u8c03\u8282\u836f\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u7eb3\u7c73\u836f\u7269\u53d6\u5f97\u4e86\u5de8\u5927\u7684\u6210\u529f\uff0c\u81f3\u4eca\u5df2\u6279\u51c6\u4e86\u7ea650\u79cd\u7eb3\u7c73\u836f\u7269\u7528\u4e8e\u4e34\u5e8a\u3002\u5c3d\u7ba1\u53d6\u5f97\u4e86\u8fd9\u4e9b\u8fdb\u5c55\uff0c\u5176\u4e2d\u4ec5\u670912\u79cd\u5c0f\u5206\u5b50\u7eb3\u7c73\u836f\u7269\u7528\u4e8e\u9759\u8109\u7ed9\u836f\u3002\u8fd9\u662f\u56e0\u4e3a\u4f20\u7edf\u7684\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u662f\u53d7\u914d\u65b9\u9a71\u52a8\u7684\uff0c\u836f\u7269\u7ed3\u6784\u7684\u591a\u6837\u6027\u548c\u8fe5\u5f02\u7684\u7406\u5316\u6027\u8d28\u660e\u663e\u963b\u788d\u4e86\u65b0\u578b\u7eb3\u7c73\u836f\u7269\u7684\u53d1\u5c55\u3002\u5728\u8fd912\u79cd\u7eb3\u7c73\u836f\u7269\u4e2d\uff0c\u670910\u79cd\u7eb3\u7c73\u836f\u7269\u662f\u8102\u8d28\u4f53\u5242\u578b\uff0c\u53ef\u7528\u4e8e\u5305\u88f9\u5177\u6709\u76f8\u4f3c\u7279\u6027\u7684\u8d1f\u8f7d\u836f\u7269\u3002\u4f46\u662f\uff0c\u7531\u4e8e\u836f\u7269\u548c\u7eb3\u7c73\u8f7d\u4f53\u4e4b\u95f4\u7684\u76f8\u5bb9\u6027\u5dee\uff0c\u56e0\u6b64\u7269\u7406\u5305\u8f7d\u7684\u7eb3\u7c73\u836f\u7269\uff0c\u4f8b\u5982\u805a\u5408\u7269\u80f6\u675f\u548c\u86cb\u767d\u8d28\u7eb3\u7c73\u9897\u7c92\uff08NPs\uff09\uff0c\u5f80\u5f80\u5b58\u5728\u836f\u7269\u7a81\u91ca\u548c\u8f7d\u836f\u91cf\u4f4e\u7b49\u95ee\u9898\u3002\u4e3a\u4e86\u7a81\u7834\u8fd9\u4e9b\u9650\u5236\uff0c\u5b9e\u65bd\u521b\u65b0\u578b\u7684\u524d\u836f\u7b56\u7565\u5bf9\u4e8e\u4f18\u5316\u6a21\u5757\u5316\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u548c\u4fc3\u8fdb\u5176\u4e34\u5e8a\u5e94\u7528\u90fd\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<p>\u3010<strong>\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n<p><strong>\u5357\u5f00\u5927\u5b66\u7684\u90ed\u672f\u6d9b\u6559\u6388\u548c\u56fd\u5bb6\u7eb3\u7c73\u4e2d\u5fc3\u7684\u6881\u5174\u6770\u6559\u6388<\/strong>\u8bbe\u8ba1\u4e86\u6a21\u5757\u5316\u7684pH\u654f\u611f\u5730\u585e\u7c73\u677e\u7f29\u916e\u524d\u836f\uff08AKP-dexs\uff09\uff0c\u5168\u9762\u7814\u7a76\u4e86AKP-dexs\u5206\u5b50\u7ed3\u6784\u4e0e\u7269\u5316\u6027\u8d28\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u5e76\u5c06\u5176\u5236\u6210\u7eb3\u7c73\u9897\u7c92\u3002\u4e4b\u540e\u6839\u636e\u7eb3\u7c73\u9897\u7c92\u5c3a\u5bf8\u3001\u8f7d\u836f\u91cf\u3001\u80f6\u4f53\u7a33\u5b9a\u6027\u3001\u6c34\u89e3\u901f\u5ea6\u7b49\u53c2\u6570\u7b5b\u9009\u51fa\u4e24\u79cd\u7c7b\u578b\u7684AKP-dexs\u7eb3\u7c73\u9897\u7c92\u8fdb\u884c\u4f53\u5185\u7814\u7a76\u3002\u5728\u80f6\u539f\u86cb\u767d\u8bf1\u53d1\u7684\u5173\u8282\u708e\u5927\u9f20\u6a21\u578b\u4e2d\uff0c\u4e0e\u6e38\u79bb\u5730\u585e\u7c73\u677e\u78f7\u9178\u94a0\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u8d1f\u8f7dAKP-dexs\u7684\u7eb3\u7c73\u7c92\u5728\u53d1\u708e\u5173\u8282\u4e2d\u8868\u73b0\u51fa\u66f4\u9ad8\u7684\u79ef\u805a\u548c\u66f4\u597d\u7684\u6cbb\u7597\u6548\u679c\uff0c\u4e14\u526f\u4f5c\u7528\u5c11\u3002\u8d1f\u8f7dAKP-dexs\u7684\u7eb3\u7c73\u9897\u7c92\u4e5f\u53ef\u7528\u4e8e\u6cbb\u7597\u5176\u4ed6\u708e\u75c7\u75be\u75c5\uff0c\u56e0\u6b64\u5177\u6709\u5de8\u5927\u7684\u4e34\u5e8a\u6f5c\u529b\u3002\u8fd9\u4e2a\u5de5\u4f5c\u8fc8\u51fa\u4e86\u9178\u654f\u611f\u7f29\u916e\u524d\u836f\u5b9e\u9645\u5e94\u7528\u7684\u91cd\u8981\u4e00\u6b65\uff0c\u5e76\u4e14\u6709\u5229\u4e8e\u6a21\u5757\u5316\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201c<\/strong><strong>Modular Acid-Activatable Acetone-Based Ketal-Linked Nanomedicine by Dexamethasone Prodrugs for Enhanced Anti-Rheumatoid Arthritis with Low Side E\ufb00ects<\/strong><strong>\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<strong>Nano Lett.<\/strong><strong>\u4e0a<\/strong>\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe<\/strong><strong>1. AKP-dexs<\/strong><strong>\u53ca\u5176\u7eb3\u7c73\u9897\u7c92\u7684\u5236\u5907\u4e0e\u8bc4\u4ef7<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-198808\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r1-3.jpg\" alt=\"\" width=\"600\" height=\"679\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r1-3.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r1-3-265x300.jpg 265w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u7531\u5730\u585e\u7c73\u677e\u548c\u5f02\u4e19\u70ef\u57fa\u919a\u5408\u6210AKP-dexs\uff0c\u7136\u540e\u901a\u8fc7\u7eb3\u7c73\u6c89\u6dc0\u6cd5\u4e0eDSPE-mPEG2000\u5171\u7ec4\u88c5\uff0c\u5f62\u6210\u8d1f\u8f7dAKP-dexs\u7684\u7eb3\u7c73\u7c92<\/p>\n<p>\uff08b\uff09\u76f8\u5e94\u7684AKP-dexs\u7684\u524d\u836f\u8f7d\u4f53\u7ed3\u6784\u548c\u540d\u79f0\u3002\u6839\u636e\u7c92\u5f84\u3001\u80f6\u4f53\u7a33\u5b9a\u6027\u548c\u9178\u654f\u611f\u6027\uff0c\u7b5b\u9009\u51fa\u4e24\u79cd\u7406\u60f3\u7684AKP-dex\u7eb3\u7c73\u7c92\u3002<\/p>\n<p>\uff08c\uff09\u5730\u585e\u7c73\u677e\u548c\u90e8\u5206AKP-dexs\u7684\u6a21\u62dfLogP\u503c<\/p>\n<p>\uff08d\uff09\u90e8\u5206AKP-dexs\u5728\u4e8c\u6c2f\u7532\u70f7\uff08DCM\uff09\u548c\u4e19\u916e\u4e2d\u7684\u6eb6\u89e3\u5ea6<\/p>\n<p>\uff08e\uff09\u90e8\u5206AKP-dexs\u5728pH 5.0\u7f13\u51b2\u6db2\u4e2d\u7684\u6c34\u89e3\u534a\u8870\u671f<\/p>\n<p>\uff08f\uff09\u4e03\u4e2aAKP-dexs\u4e0d\u540c\u914d\u6599\u6bd4\u6240\u5f97\u7eb3\u7c73\u7c92\u60c5\u51b5\u7b80\u56fe<\/p>\n<p><strong>\u56fe<\/strong><strong>2. <\/strong><strong>\u8d1f\u8f7d<\/strong><strong>AKP-dexs<\/strong><strong>\u7684\u7eb3\u7c73\u7c92\u7684\u4f53\u5916\u8868\u5f81<\/strong><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-198809\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r2-3.jpg\" alt=\"\" width=\"600\" height=\"501\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r2-3.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r2-3-300x251.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09\u8d1f\u8f7dSKD\u7684\u7eb3\u7c73\u7c92\u548c\u8d1f\u8f7d2&#8217;NKD\u7684\u7eb3\u7c73\u7c92\u7684\u4ee3\u8868\u6027\u900f\u5c04\u7535\u955c\u56fe\u50cf<\/p>\n<p>\uff08b\uff09\u5927\u9f20\u8840\u6e05\u4e2d\u8d1f\u8f7dSKD\u7684\u7eb3\u7c73\u7c92\u548c\u8d1f\u8f7d2&#8217;NKD\u7684\u7eb3\u7c73\u7c92\u7684\u524d\u836f\u6c34\u89e3\u5ea6\uff08\uff05\uff09<\/p>\n<p>\uff08c\uff09\u8d1f\u8f7d2&#8217;NKD\u7684\u7eb3\u7c73\u7c92\u548c\u8d1f\u8f7dSKD\u7684\u7eb3\u7c73\u7c92\u5bf9Raw 264.7\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027<\/p>\n<p>\uff08d\uff09\u5b75\u80b224\u5c0f\u65f6\u540e\uff0c\u6b63\u5e38\u548cLPS\u523a\u6fc0\u7684Raw 264.7\u5de8\u566c\u7ec6\u80de\u6444\u53d6\u6e38\u79bbDID\u548c\u8d1f\u8f7dAKP-dexs\u7684\u7eb3\u7c73\u7c92\uff08\u5171\u8f7dDID\uff09\u7684\u5171\u805a\u7126\u663e\u5fae\u955c\u56fe\u50cf\u3002<\/p>\n<p><strong>\u56fe<\/strong><strong>3. ELVIS<\/strong><strong>\u6548\u5e94\u7684\u7814\u7a76<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-198810\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r3-3.jpg\" alt=\"\" width=\"600\" height=\"637\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r3-3.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r3-3-283x300.jpg 283w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u6b63\u5e38\u5927\u9f20\u548cCIA\u5927\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04\u6e38\u79bbDID\u6216\u8d1f\u8f7dAKP-dex\u7684\u7eb3\u7c73\u7c92\uff08\u5171\u8f7dDID\uff09\u540e\uff0c\u7b2c4\u5c0f\u65f6\u548c\u7b2c24\u5c0f\u65f6\u7684\u8367\u5149\u6210\u50cf<\/p>\n<p>\uff08b\uff09\u5355\u6b21\u5c3e\u9759\u8109\u6ce8\u5c04\u8d1f\u8f7dSKD\u7684\u7eb3\u7c73\u7c92\uff08\u5171\u8f7dDID\uff09\u548c\u8d1f\u8f7d2&#8217;NKD\u7684\u7eb3\u7c73\u7c92\uff08\u5171\u8f7dDID\uff09\u540e\u7b2c24\u5c0f\u65f6\uff0c\u6b63\u5e38\u5927\u9f20\u548cCIA\u5927\u9f20\u7684\u5173\u8282\u90e8\u4f4d\u8367\u5149\u4fe1\u53f7\u5f3a\u5ea6\u6bd4\u8f83<\/p>\n<p>\uff08c\uff09\u5355\u6b21\u5c3e\u9759\u8109\u6ce8\u5c04\u6e38\u79bbDID\uff0c\u8d1f\u8f7dSKD\u7684\u7eb3\u7c73\u7c92\uff08\u5171\u8f7dDID\uff09\u548c\u8d1f\u8f7d2&#8217;NKD\u7684\u7eb3\u7c73\u7c92\uff08\u5171\u8f7dDID\uff09\u540e\u7684\u7b2c4\u548c24\u5c0f\u65f6\uff0cCIA\u5927\u9f20\u7684\u5173\u8282\u90e8\u4f4d\u8367\u5149\u4fe1\u53f7\u6bd4\u8f83<\/p>\n<p><strong>\u56fe<\/strong><strong>4. AKP-dexs <\/strong><strong>\u7eb3\u7c73\u7c92\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u751f\u7269\u5206\u5e03<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-198811\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r4-3.jpg\" alt=\"\" width=\"600\" height=\"535\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r4-3.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r4-3-300x268.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a,b\uff09\u4e0d\u540c\u65f6\u95f4\u70b9\u6e38\u79bb\u5730\u585e\u7c73\u677e\u548c\u603b\u5730\u585e\u7c73\u677e\u7684\u8840\u6d46\u6d53\u5ea6<\/p>\n<p>\uff08c\uff09\u4e0d\u540c\u5236\u5242\u7684\u6e38\u79bb\u5730\u585e\u7c73\u677e\u548c\u603b\u5730\u585e\u7c73\u677e\u7684AUC<\/p>\n<p>\uff08d,e\uff09\u57284 h\u65f6\u6e38\u79bb\u5730\u585e\u7c73\u677e\u548c\u603b\u5730\u585e\u7c73\u677e\u7684\u6bcf\u514b\u7ec4\u7ec7\u767e\u5206\u6ce8\u5c04\u5242\u91cf\u7387<\/p>\n<p>\uff08f\uff09\u572824 h\u5404\u4e2a\u5668\u5b98\u548c\u5173\u8282\u4e2d\u6e38\u79bb\u5730\u585e\u7c73\u677e\u5360\u603b\u5730\u585e\u7c73\u677e\u7684\u6bd4\u4f8b<\/p>\n<p>\uff08g,h\uff09\u57284 h\u65f6\u6e38\u79bb\u5730\u585e\u7c73\u677e\u548c\u603b\u5730\u585e\u7c73\u677e\u7684\u6bcf\u514b\u7ec4\u7ec7\u767e\u5206\u6ce8\u5c04\u5242\u91cf\u7387<\/p>\n<p>\uff08i\uff09\u572824 h\u5404\u4e2a\u5668\u5b98\u548c\u5173\u8282\u4e2d\u6e38\u79bb\u5730\u585e\u7c73\u677e\u5360\u603b\u5730\u585e\u7c73\u677e\u7684\u6bd4\u4f8b<\/p>\n<p><strong>\u56fe<\/strong><strong>5. <\/strong><strong>\u4e0d\u540c\u5236\u5242\u5bf9<\/strong><strong>CIA<\/strong><strong>\u5927\u9f20\u6a21\u578b\u7684\u4f53\u5185\u6cbb\u7597\u4f5c\u7528<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-198812\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r5-2.jpg\" alt=\"\" width=\"600\" height=\"785\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r5-2.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r5-2-229x300.jpg 229w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09CIA\u6a21\u578b\u793a\u610f\u56fe\u548c\u6cbb\u7597\u65b9\u6848\u65f6\u95f4\u8868<\/p>\n<p>\uff08b-i\uff09\u5173\u8282\u708e\u8bc4\u5206<\/p>\n<p>\uff08b-ii\uff09\u8db3\u8dd6\u539a\u5ea6\u8bc4\u4ef7<\/p>\n<p>\uff08c,d\uff09\u5728\u7b2c28\u5929\u901a\u8fc7ELISA\u6d4b\u91cf\u8840\u6e05TNF-\u03b1\u548cIL-1\u03b2\u6c34\u5e73<\/p>\n<p>\uff08e\uff09\u4e0d\u540c\u6cbb\u7597\u65b9\u5f0f\u7684\u6b63\u5e38\u5927\u9f20\u548cCIA\u5927\u9f20\u5173\u8282\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u5206\u6790<\/p>\n<p><strong>\u56fe<\/strong><strong>6. <\/strong><strong>\u5fae\u578b<\/strong><strong>CT<\/strong><strong>\u5206\u6790\u4e0d\u540c\u5242\u578b\u5bf9\u6b63\u5e38\u5927\u9f20\u548c<\/strong><strong>CIA<\/strong><strong>\u5927\u9f20\u540e\u722a\u7684\u6cbb\u7597\u4f5c\u7528<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-198813\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r6-2.jpg\" alt=\"\" width=\"600\" height=\"772\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r6-2.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/03\/r6-2-233x300.jpg 233w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u7b2c28\u5929\u65f6\u8e1d\u5173\u8282\u7684\u4ee3\u8868\u6027\u5fae\u578bCT\u56fe\u50cf<\/p>\n<p>\uff08b\uff09\u9aa8\u5c0f\u6881\u7684\u4ee3\u8868\u6027\u56fe\u50cf<\/p>\n<p>\uff08c\uff09ROI\u7684\u4e09\u7ef4\u5c0f\u6881\u7ed3\u6784<\/p>\n<p>\uff08d-i\uff09\u4ece\u5fae\u578bCT\u6570\u636e\u5206\u6790\u83b7\u5f97\u7684\u7ec4\u7ec7\u5f62\u6001\u8ba1\u91cf\u5b66\u53c2\u6570<\/p>\n<p><strong>\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n<p>\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u4f7f\u7528\u5730\u585e\u7c73\u677e\u4f5c\u4e3a\u6a21\u578b\u836f\u7269\u8fdb\u884c\u6a21\u5757\u5316\u53ef\u8c03\u8282\u7684pH\u654f\u611f\u7f29\u916e\u524d\u836f\u5408\u6210\uff0c\u5e76\u5c55\u793a\u4e86\u5408\u7406\u7684AKP-dexs\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u3002\u8fd9\u4e9b\u524d\u836f\u4e0eDSPE-mPEG2000\u5171\u7ec4\u88c5\u4ee5\u5236\u5907\u7528\u4e8e\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u6cbb\u7597\u7684\u7eb3\u7c73\u836f\u7269\u3002\u4f7f\u7528\u957f\u78b3\u94fe\u9187\u4f5c\u4e3a\u524d\u836f\u8f7d\u4f53\uff0c\u53ef\u4ee5\u4f7f\u5730\u585e\u7c73\u677e\u4e0eDSPE-mPEG2000\u4e4b\u95f4\u5177\u6709\u66f4\u597d\u7684\u76f8\u5bb9\u6027\uff0c\u5e76\u53ef\u4ee5\u5236\u5907\u5177\u6709\u9ad8AKP-dexs\u8f7d\u836f\u91cf\u548c\u5305\u5c01\u7387\u7684\u7a33\u5b9a\u7eb3\u7c73\u7c92\u3002\u5728\u4f53\u5185\u5b9e\u9a8c\u4e2d\uff0c\u8d1f\u8f7dAKP-dexs\u7684\u7eb3\u7c73\u7c92\u5728\u53d1\u708e\u5173\u8282\u4e2d\u663e\u793a\u51fa\u66f4\u9ad8\u7684\u79ef\u7d2f\u91cf\uff0c\u5e76\u4e14\u7eb3\u7c73\u7c92\u5728\u5173\u8282\u7684\u9178\u6027\u5fae\u73af\u5883\u4e2d\u6709\u6548\u5730\u91ca\u653e\u4e86\u5730\u585e\u7c73\u677e\uff0c\u63d0\u9ad8\u4e86\u5bf9\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u6cbb\u7597\u6548\u679c\u5e76\u51cf\u5c11\u4e86\u7cfb\u7edf\u6027\u526f\u4f5c\u7528\u3002\u8fd9\u9879\u7814\u7a76\u662f\u4f7f\u7528\u7f29\u916e\u524d\u836f\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u9996\u6b21\u62a5\u9053\uff0c\u8fd9\u4e2a\u53d1\u73b0\u53ef\u80fd\u4f1a\u4fc3\u8fdb\u5404\u79cd\u57fa\u4e8e\u7f29\u916e\u524d\u836f\u7684\u6297\u708e\u5236\u5242\u7684\u53d1\u5c55\uff0c\u4f8b\u5982\u957f\u6548\u5fae\u7403\u548c\u7eb3\u7c73\u6676\u3002\u9274\u4e8eAKP-dexs\u7684\u6240\u6709\u6c34\u89e3\u526f\u4ea7\u7269\u90fd\u662f\u751f\u7269\u76f8\u5bb9\u6027\u597d\u7684\u65e0\u6bd2\u6750\u6599\uff0cAKP-dexs\u53ef\u80fd\u4f1a\u4fc3\u8fdb\u6297\u708e\u75c7\u7eb3\u7c73\u836f\u7269\u7684\u4e34\u5e8a\u8f6c\u5316\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u9879\u7814\u7a76\u8bc1\u660e\u4e86\u7f29\u916e\u524d\u836f\u662f\u4e00\u79cd\u53ef\u4ee5\u5728\u4f53\u5185\u6709\u6548\u8f6c\u5316\u4e3a\u539f\u836f\u7684pH\u654f\u611f\u524d\u836f\u8bbe\u8ba1\u7b56\u7565\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5<\/strong>\uff1a<strong>Modular Acid-Activatable Acetone-Based Ketal-Linked Nanomedicine by Dexamethasone Prodrugs for Enhanced Anti-Rheumatoid Arthritis with Low Side E\ufb00ects<\/strong>. <em>Nano Lett., <\/em><strong>2020<\/strong>, DOI: 10.1021\/acs.nanolett.9b05340.<\/p>\n<p>\u672c\u6587\u7531tt\u4f9b\u7a3f\u3002\u00a0<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenvip\u3002\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 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