{"id":198797,"date":"2020-03-27T06:15:19","date_gmt":"2020-03-26T22:15:19","guid":{"rendered":"\/\/m.iemloyee.com\/?p=198797"},"modified":"2020-03-26T22:15:43","modified_gmt":"2020-03-26T14:15:43","slug":"%e6%b5%99%e5%a4%a7%e6%9c%b1%e8%94%9a%e7%92%9e%e8%af%be%e9%a2%98%e7%bb%84macromolecules%ef%bc%9a%e7%ab%af%e7%be%a7%e5%9f%ba%e9%85%af%e4%ba%a4%e6%8d%a2%e6%b3%95%e5%90%88%e6%88%90%e7%94%9f%e7%89%a9","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=198797","title":{"rendered":"\u6d59\u5927\u6731\u851a\u749e\u8bfe\u9898\u7ec4Macromolecules\uff1a\u7aef\u7fa7\u57fa\u916f\u4ea4\u6362\u6cd5\u5408\u6210\u751f\u7269\u53ef\u964d\u89e3\u7684\u9ad8\u5206\u5b50\u91cf\u805a\u4e59\u4e8c\u9187"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u7531\u4e8e\u5176\u65e0\u6bd2\uff0c\u6297\u86cb\u767d\u5438\u9644\u548c\u975e\u514d\u75ab\u539f\u6027\uff0c\u662f\u5236\u836f\u5de5\u4e1a\u4e2d\u4f7f\u7528\u6700\u5e7f\u6cdb\u7684\u751f\u7269\u805a\u5408\u7269\u4e4b\u4e00\u3002PEG\u94fe\u4e0e\u751f\u7269\u6d3b\u6027\u6cbb\u7597\u7269\u8d28\uff08\u4f8b\u5982\uff0c\u836f\u7269\u86cb\u767d\uff0c\u591a\u80bd\u548c\u5176\u4ed6\u836f\u7269\u5206\u5b50\uff09\u7684\u5171\u4ef7\u8fde\u63a5\uff08\u79f0\u4e3aPEG\u5316\uff09\u53ef\u4ee5\u589e\u52a0\u8fd9\u4e9b\u836f\u7269\u7684\u5316\u5b66\u7a33\u5b9a\u6027\u548c\u751f\u7269\u5faa\u73af\u65f6\u95f4\u3002\u6b64\u5916\uff0cPEG\u5177\u6709\u201c\u9690\u9041\u201d\u6548\u5e94\uff0c\u53ef\u907f\u514d\u7ec6\u80de\u541e\u566c\u4f5c\u7528\uff0c\u4ece\u800c\u964d\u4f4ePEG\u5316\u5076\u5408\u7269\u7684\u514d\u75ab\u539f\u6027\u3002\u76ee\u524d\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u5df2\u7ecf\u6279\u51c6\u4e86\u8bb8\u591a\u805a\u4e59\u4e8c\u9187\u5316\u836f\u7269\u3002\u5df2\u6709\u7684\u7814\u7a76\u53d1\u73b0\u805a\u4e59\u4e8c\u9187\u5316\u836f\u7269\u7684\u529f\u6548\u9ad8\u5ea6\u4f9d\u8d56\u4e8e\u805a\u4e59\u4e8c\u9187\u7684\u5206\u5b50\u91cf\u3002\u4f46\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cPEG\u5728\u4f53\u5185\u65e0\u6cd5\u964d\u89e3\uff0c\u5176\u4ee3\u8c22\u673a\u7406\u53d6\u51b3\u4e8e\u5176\u5206\u5b50\u91cf\u3002\u4f4e\u4e8e10 kDa\u5206\u5b50\u91cf\u7684PEG\u53ef\u901a\u8fc7\u80be\u810f\u6ee4\u8fc7\u4f5c\u7528\u6392\u51fa\uff0c\u800c\u8f83\u5927\u5206\u5b50\u91cf\u7684PEG\u5219\u4e0d\u80fd\u88ab\u809d\u810f\u6709\u6548\u964d\u89e3\uff0c\u518d\u901a\u8fc7\u80be\u810f\u8fdb\u884c\u6e05\u9664\uff0c\u8fd9\u4f1a\u5bfc\u81f4PEG\u5728\u8fd9\u4e9b\u5668\u5b98\u4e2d\u84c4\u79ef\u5e76\u589e\u52a0\u4e2d\u6bd2\u7684\u98ce\u9669\u3002\u56e0\u6b64\uff0c\u7528\u4e8e\u6cbb\u7597\u7528\u9014\u7684PEG\u7684\u5206\u5b50\u91cf\u901a\u5e38\u4e0d\u8d85\u8fc710kDa\uff0c\u4ee5\u786e\u4fdd\u80fd\u591f\u5b8c\u5168\u88ab\u80be\u5c0f\u7403\u6ee4\u9664\u3002\u514b\u670d\u6b64\u7f3a\u70b9\u7684\u6709\u6548\u89e3\u51b3\u65b9\u6848\u662f\u5c06\u53ef\u751f\u7269\u964d\u89e3\u7684\u5b98\u80fd\u56e2\u5f15\u5165PEG\u4e3b\u94fe\u7ed3\u6784\u6765\u5408\u6210\u53ef\u751f\u7269\u964d\u89e3\u7684PEG\uff0c\u5176\u4e2d\u542b\u6709\u8d85\u8fc795\uff05\u7684PEG\u6210\u5206\uff0c\u56e0\u6b64\u53ef\u4fdd\u6301PEG\u672c\u8eab\u7684\u4f18\u826f\u6027\u8d28\u3002\u6839\u636e\u8be5\u7b56\u7565\uff0c\u4ee5\u5f80\u7684\u7814\u7a76\u8005\u5c06\u916f\u952e\u3001\u9170\u80fa\u952e\u3001\u4e8c\u786b\u952e\u548c\u4e59\u70ef\u57fa\u919a\u7b49\u53ef\u964d\u89e3\u57fa\u56e2\u5f15\u5165\u5230PEG\u4e3b\u94fe\u4e2d\u3002\u4f46\u8fd9\u4e9b\u7b56\u7565\u5927\u591a\u6570\u90fd\u9700\u8981\u7279\u5b9a\u529f\u80fd\u5316\u7684PEG\u5355\u4f53\u548c\u7e41\u7410\u7684\u591a\u6b65\u5408\u6210\u3002<\/p>\n

\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0c\u53ef\u751f\u7269\u964d\u89e3\u7684PEG\u53ef\u4ee5\u901a\u8fc7\u5546\u54c1\u5316\u7684PEG\u4e8c\u9187\uff08\u5e02\u552ePEG\u7684\u7aef\u57fa\u591a\u4e3a\u7f9f\u57fa\uff09\u548c\u4e8c\u5143\u7fa7\u9178\u4e4b\u95f4\u8fdb\u884c\u805a\u916f\u5316\u53cd\u5e94\u76f4\u63a5\u5236\u5907\u3002\u7136\u800c\uff0c\u7531\u4e8ePEG\u805a\u916f\u5316\u7684\u56f0\u96be\uff0c\u5f88\u96be\u901a\u8fc7\u8fd9\u79cd\u9014\u5f84\u83b7\u5f97\u9ad8\u5206\u5b50\u91cf\uff08HMW\uff09\u4ea7\u7269\u3002\u5176\u7b2c\u4e00\u4e2a\u6311\u6218\u662f\u805a\u916f\u5316\u7684\u53cd\u5e94\u7a0b\u5ea6\u53d7\u5236\u4e8e\u5176\u8f83\u5c0f\u7684\u916f\u5316\u5e73\u8861\u5e38\u6570\uff08~4\uff09\u3002\u5176\u6b21\uff0c\u7531\u4e8e\u5176\u9010\u6b65\u751f\u957f\u7684\u673a\u7406\uff0c\u6839\u636eCarothers\u7684\u7406\u8bba\uff0c\u8be5\u805a\u916f\u5316\u53cd\u5e94\u9700\u8981\u4f7f\u7528\u9ad8\u7eaf\u5ea6\u5355\u4f53\u548c\u7cbe\u786e\u7684\u7b49\u57fa\u56e2\u6bd4\u3002\u6b64\u5916\uff0cPEG\u4e8c\u9187\u7684\u591a\u5206\u6563\u6027\u4f7f\u5176\u96be\u4ee5\u5b9a\u91cf\uff0c\u4e14\u5927\u591a\u6570\u4e8c\u5143\u7fa7\u9178\u7531\u4e8e\u5347\u534e\u6216\u526f\u53cd\u5e94\u800c\u4f1a\u5728\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u635f\u5931\u6389\u3002\u8fd9\u4e9b\u56e0\u7d20\u5bfc\u81f4\u7fa7\u57fa\u548c\u7f9f\u57fa\u96be\u4ee5\u8fbe\u5230\u7cbe\u786e\u7684\u7b49\u914d\u6bd4\uff0c\u5bfc\u81f4\u4e86\u4ea7\u7269\u7684\u4f4e\u5206\u5b50\u91cf\uff08\u901a\u5e38<20 kDa\uff09\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u6d59\u6c5f\u5927\u5b66\u6731\u851a\u749e\u526f\u6559\u6388<\/strong>\u56e2\u961f\u5408\u4f5c\u5229\u7528\u7aef\u7fa7\u57fa\u916f\u4ea4\u6362\u6cd5\u5408\u6210\u4e86\u751f\u7269\u53ef\u964d\u89e3\u7684\u9ad8\u5206\u5b50\u91cf\u805a\u4e59\u4e8c\u9187\u3002\u4f5c\u8005\u901a\u8fc7PEG\u4e8c\u9187\u548c\u8fc7\u91cf\u7684\u4e8c\u5143\u7fa7\u9178\u8fdb\u884c\u7194\u878d\u7f29\u805a\u65b9\u5f0f\u5408\u6210\u4e86\u53ef\u751f\u7269\u964d\u89e3\u7684PEG\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8fd8\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u7aef\u7fa7\u57fa\u916f\u4ea4\u6362\u673a\u5236\uff0c\u5176\u514b\u670d\u4e86\u4f20\u7edf\u916f\u5316\u7b56\u7565\u5408\u6210\u9ad8\u5206\u5b50\u91cf\u4ea7\u7269\u7684\u56f0\u96be\uff0c\u5236\u5907\u51fa\u5206\u5b50\u91cf\u9ad8\u8fbe112.6 kDa\u7684\u53ef\u751f\u7269\u964d\u89e3PEG\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u8fd9\u4e9b\u53ef\u751f\u7269\u964d\u89e3PEG\u7684\u6027\u8d28\u53ef\u6bd4\u62df\u4e8e\u540c\u7b49\u5206\u5b50\u91cf\u7684\u4e0d\u53ef\u964d\u89e3\u7684\u666e\u901aPEG\uff0c\u5e76\u4e14\u5b83\u4eec\u7684\u916f\u952e\u88c2\u89e3\u540e\u53ef\u4ee5\u5728\u4f53\u5185\u88ab\u4ee3\u8c22\u6389\u3002\u76f8\u5173\u6210\u679c\u4ee5\u201cHigh Molecular Weight Biodegradable Poly(ethylene glycol) via Carboxyl-Ester Transesterification<\/strong>\u201d\u53d1\u8868\u4e8eMacromolecules<\/strong>\u671f\u520a\u4e0a\u3002\u8bba\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u4e3a\u6d59\u6c5f\u5927\u5b66\u9ad8\u5206\u5b50\u7cfb\u535a\u58eb\u7814\u7a76\u751f\u8521\u79cb\u6cc9\uff0c\u901a\u8baf\u4f5c\u8005\u4e3a\u6d59\u6c5f\u5927\u5b66\u9ad8\u5206\u5b50\u7cfb\u6731\u851a\u749e\u526f\u6559\u6388\uff0c\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u53e3\u8154\u533b\u9662\u674e\u6653\u4e1c\u7814\u7a76\u5458\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/p>\n

\u00a0<\/strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

Scheme 1.<\/strong>\u901a\u8fc7\u5c06\u916f\u952e\u5f15\u5165\u5230<\/strong>PEG<\/strong>\u4e3b\u94fe\u4e0a\u5236\u5907\u53ef\u751f\u7269\u964d\u89e3<\/strong>PEG<\/strong><\/p>\n

\"\"<\/p>\n

Scheme 2.<\/strong>\u4e24\u79cd\u916f\u4ea4\u6362\u8fc7\u7a0b\u7684\u6bd4\u8f83<\/strong><\/p>\n

\"\"\uff08a\uff09\u4f7f\u7528\u8fc7\u91cf\u7684\u4e8c\u5143\u7fa7\u9178\u8fdb\u884c\u7aef\u7fa7\u57fa\u916f\u4ea4\u6362\u53cd\u5e94\uff0c\u4ee5\u5408\u6210\u53ef\u751f\u7269\u964d\u89e3\u7684HMWPEG\uff1b<\/p>\n

\uff08b\uff09\u5229\u7528\u5206\u5b50\u94fe\u7684\u672b\u7aef\u7fa7\u57fa-\u916f\u952e\u4e4b\u95f4\u7684\u4ea4\u6362\u53cd\u5e94\u6765\u8131\u9664\u8fc7\u91cf\u7684\u5c0f\u5206\u5b50\u4e8c\u9178\uff0c\u4ece\u800c\u903c\u8fd1\u7f9f\u57fa\u548c\u7fa7\u57fa\u7684\u7b49\u914d\u6bd4\uff0c\u5728\u7194\u878d\u7f29\u805a\u65b9\u5f0f\u4e0b\u5408\u6210\u4e86\u53ef\u751f\u7269\u964d\u89e3\u7684HMWPEG\uff1b<\/p>\n

\uff08c\uff09PEG\u8fc7\u91cf\u65f6\uff0c\u7531\u4e8e\u542bPEG\u7684\u94fe\u6bb5\u5206\u5b50\u91cf\u8f83\u5927\uff0c\u4e0d\u5177\u6709\u53ef\u6325\u53d1\u6027\u800c\u65e0\u6cd5\u88ab\u6392\u51fa\u4f53\u7cfb\uff0c\u672b\u7aef\u7f9f\u57fa-\u916f\u952e\u4e4b\u95f4\u53ef\u53d1\u751f\u4ea4\u6362\uff08\u7aef\u7f9f\u57fa\u916f\u4ea4\u6362\uff09\uff0c\u4f46\u4ea7\u7269\u5206\u5b50\u91cf\u6ca1\u6709\u53d8\u5316\u3002<\/p>\n

\u56fe\u4e00\u3001\u916f\u4ea4\u6362\u524d\u9884\u805a\u7269<\/strong>SA<\/strong>\u548c<\/strong>PEG600<\/sub><\/strong>\u7684\u8d28\u8c31\u5206\u6790<\/strong><\/p>\n

\"\"\u9884\u805a\u4f53\u7684\u94fe\u7aef\u662f\u7fa7\u57fa\u5c01\u7aef\uff0c\u56e0\u6b64\u4e0d\u80fd\u901a\u8fc7\u4f20\u7edf\u7684\u916f\u5316\u53cd\u5e94\u8fdb\u884c\u94fe\u589e\u957f\u3002<\/p>\n

\u56fe\u4e8c\u3001<\/strong>SA<\/strong>\u548c<\/strong>PEG600<\/sub><\/strong>\u7684\u7f29\u805a\u52a8\u529b\u5b66<\/strong><\/p>\n

\"\"\uff08a\uff09\u5728180\u2103\u4e0b\uff0cSA\/PEG600<\/sub>\u5728\u805a\u5408\u7269\u4e2d\u7684\u6bd4\u4f8b\uff0c\u6570\u5747\u5206\u5b50\u91cf\uff08Mn\uff09\u548c\u5206\u5b50\u91cf\u5206\u5e03\uff08D\u0335\uff09\u968f\u65f6\u95f4\u7684\u53d8\u5316\uff1b<\/p>\n

\uff08b\uff09\u5728160\u2103(\u5de6)\u548c180\u2103(\u53f3)\u4e24\u79cd\u6e29\u5ea6\u4e0b\uff0cln{[COOH]0<\/sub>\/[COOH]}\u4e0e\u916f\u4ea4\u6362\u53cd\u5e94\u65f6\u95f4\u7684\u51fd\u6570\u5173\u7cfb\u3002<\/p>\n

\u00a0<\/strong>\u56fe\u4e09\u3001\u53ef\u751f\u7269\u964d\u89e3<\/strong>PEG<\/strong>\u7684\u6d41\u4f53\u529b\u5b66\u76f4\u5f84\uff0c\u6297\u86cb\u767d\u8d28\u5438\u9644\u548c\u7ec6\u80de\u76f8\u5bb9\u6027<\/strong><\/p>\n

\"\"\uff08a\uff09\u53ef\u751f\u7269\u964d\u89e3PEG\uff08PEG600<\/sub>–alt<\/em>-SA\uff0cPEG1k<\/sub>–alt<\/em>-SA\uff0cPEG2k<\/sub>–alt<\/em>-SA\uff0cPEG4k<\/sub>–alt<\/em>-SA\u548cPEG10k<\/sub>–alt<\/em>-SA\uff09\u548c\u666e\u901aPEG\uff08PEG35k<\/sub>\uff09\u7684\u6d41\u4f53\u529b\u5b66\u76f4\u5f84\uff1b<\/p>\n

\uff08b\uff09\u5355\u4f4d\u91cd\u91cf\u4eba\u7ea4\u7ef4\u86cb\u767d\u539f\u5438\u9644\u7684\u53ef\u751f\u7269\u964d\u89e3PEG\u548cPEG35k<\/sub>\u7684\u91cf\uff1b<\/p>\n

\uff08c\uff09\u53ef\u751f\u7269\u964d\u89e3PEG\u548cPEG35k<\/sub>\u5bf9\u4eba\u8840\u7ea2\u7ec6\u80de\u7684\u6eb6\u8840\u4f5c\u7528;<\/p>\n

\uff08d\uff09\u53ef\u964d\u89e3PEG\u548cPEG35k<\/sub>\u5b58\u5728\u4e0b\u7684MC3T3-E1\u7ec6\u80de\u5b58\u6d3b\u7387\u3002<\/p>\n

\u56fe\u56db\u3001\u53ef\u751f\u7269\u964d\u89e3<\/strong>PEG<\/strong>\u53ca\u5176\u5076\u5408\u7269\u7684\u514d\u75ab\u539f\u6027<\/strong><\/p>\n

\"\"\uff08a\uff09\u53ef\u751f\u7269\u964d\u89e3PEG\u5076\u5408\u7684\u725b\u8840\u6e05\u86cb\u767d\uff08BSA\uff09\u964d\u4f4e\u4e86\u5176\u514d\u75ab\u539f\u6027\uff1a<\/p>\n

\uff08b\uff09\u91c7\u7528Balb\/c\u5c0f\u9f20\u4f5c\u4e3a\u52a8\u7269\u6a21\u578b\u6ce8\u5c04\u805a\u5408\u7269\u548c\u805a\u5408\u7269-BSA\u5076\u5408\u7269\uff0c\u5e76\u5206\u522b\u572810\u5929\u548c20\u5929\u540e\u4f7f\u7528\u95f4\u63a5ELISA\u68c0\u6d4b\u5176\u8840\u6e05\u4e2d\u4ea7\u751f\u7684\u6297\u4f53\uff08IgG\u548cIgM\uff09\u542b\u91cf\u3002<\/p>\n

\u56fe\u4e94\u3001\u53ef\u751f\u7269\u964d\u89e3\u7684<\/strong>PEG<\/strong>\u5076\u5408\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u53ca\u5176\u751f\u7269\u5206\u5e03<\/strong><\/p>\n

\"\"\uff08a\uff09\u901a\u8fc7\u5411\u96cc\u6027SD\u5927\u9f20\u9759\u8109\u6ce8\u5c04\u805a\u5408\u7269-Cy5.5\u5076\u5408\u7269\uff08Cy5.5\u4f5c\u4e3a\u8367\u5149\u6807\u8bb0\u7269\u8d28\uff09\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u66f2\u7ebf\uff1b<\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aHigh Molecular Weight Biodegradable Poly(ethylene glycol) via Carboxyl-Ester Transesterification<\/a>\uff08Macromolecules<\/em>. 2020<\/strong>, DOI: https:\/\/dx.doi.org\/10.1021\/acs.macromol.9b02177.\uff09<\/p>\n

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