{"id":198010,"date":"2020-03-24T06:17:44","date_gmt":"2020-03-23T22:17:44","guid":{"rendered":"\/\/m.iemloyee.com\/?p=198010"},"modified":"2020-03-23T20:18:29","modified_gmt":"2020-03-23T12:18:29","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-%e6%b4%bb%e4%bd%93nir%e5%93%8d%e5%ba%94aza-bodipy%e7%ba%b3%e7%b1%b3%e8%81%9a%e9%9b%86%e4%bd%93%ef%bc%9a%e5%8e%9f%e4%bd%8d%e4%ba%8c%e6%80%81%e8%bd%ac%e5%8c%96","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=198010","title":{"rendered":"ACS Nano:\u6d3b\u4f53NIR\u54cd\u5e94Aza-BODIPY\u7eb3\u7c73\u805a\u96c6\u4f53\uff1a\u539f\u4f4d\u4e8c\u6001\u8f6c\u5316\u589e\u5f3a\u5b9e\u4f53\u7624\u7684\u7a7f\u900f\u6027"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u4f17\u6240\u5468\u77e5\uff0c\u7eb3\u7c73\u836f\u7269\u7684\u7ed9\u836f\u8fc7\u7a0b\u5305\u62ec\u5faa\u73af\u3001\u79ef\u7d2f\u3001\u6e17\u900f\u3001\u5185\u541e\u3001\u836f\u7269\u91ca\u653e\u7b49\u51e0\u4e2a\u6b65\u9aa4\uff0c\u6bcf\u4e00\u6b65\u7684\u4f4e\u6548\u76f4\u63a5\u9650\u5236\u4e86\u6cbb\u7597\u6548\u679c\u3002\u540c\u65f6\uff0c\u7eb3\u7c73\u836f\u7269\u7684\u957f\u6548\u8840\u6db2\u5faa\u73af\u548c\u6df1\u5c42\u6e17\u900f\u4ecd\u7136\u662f\u9700\u8981\u89e3\u51b3\u7684\u5173\u952e\u95ee\u9898\uff0c\u5b83\u4eec\u901a\u5e38\u53d7\u7eb3\u7c73\u836f\u7269\u5c3a\u5bf8\u548c\u5f62\u6001\u7684\u5f71\u54cd\u3002\u867d\u7136\u8815\u866b\u72b6\u7eb3\u7c73\u836f\u7269\u6bd4\u7403\u5f62\u7eb3\u7c73\u836f\u7269\u6709\u957f\u5faa\u73af\u4f18\u52bf\uff0c\u7531\u4e8e\u7ec4\u7ec7\u6db2\u538b\u9ad8\u548c\u80bf\u7624\u90e8\u4f4d\u8840\u7ba1\u7684\u7f3a\u4e4f\uff0c\u8815\u866b\u72b6\u7eb3\u7c73\u836f\u7269\u96be\u4ee5\u5b9e\u73b0\u6df1\u5c42\u6e17\u900f\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u7eb3\u7c73\u836f\u7269\u539f\u4f4d\u5f62\u6001\u8f6c\u5316\u7b56\u7565\u4ee5\u6539\u5584\u8840\u6db2\u5faa\u73af\u5e76\u540c\u65f6\u5b9e\u73b0\u6df1\u5c42\u6e17\u900f\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0cBODIPY\u7c7b\u67d3\u6599\u56e0\u5176\u4f18\u5f02\u7684\u5149\u5b66\u6027\u80fd\u548c\u826f\u597d\u7684\u751f\u7406\u7a33\u5b9a\u6027\uff0c\u5728\u5149\u70ed\u7597\u6cd5\u548c\u5149\u52a8\u529b\u7597\u6cd5\u4e2d\u5f97\u5230\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u5728\u6211\u4eec\u4e4b\u524d\u7684\u7814\u7a76\u4e2d\uff0c\u867d\u7136\u53d1\u73b0\u4e86\u4e00\u7c7b\u4e24\u4eb2\u6027\u7684aza-BODIPY\u4f53\u7cfb\u5728\u53d7\u70ed\u6761\u4ef6\u4e0b\u53ef\u4ee5\u7531\u70ed\u529b\u5b66\u7a33\u5b9a\u7684\u7ea4\u7ef4\u72b6\u805a\u96c6\u4f53\u8f6c\u53d8\u4e3a\u4e9a\u7a33\u6001\u7684\u7403\u5f62\u7eb3\u7c73\u9897\u7c92\uff0c\u4f46\u662f\u6b64\u79cd\u72ec\u7279\u7684\u6750\u6599\u6027\u8d28\u5c1a\u672a\u5728\u751f\u7269\u533b\u5b66\u65b9\u9762\u5f97\u5230\u5e94\u7528\u3002\u672c\u7814\u7a76\u4e2d\u5145\u5206\u5229\u7528\u4e86\u4e24\u4eb2\u6027aza-BODIPY\u4f53\u7cfb\u7684\u4e0a\u8ff0\u7279\u6027\u5f00\u5c55\u7814\u7a76\uff0c\u5e76\u901a\u8fc7PA\u6210\u50cf\u76d1\u6d4b\u5176\u5f62\u6001\u8f6c\u53d8\u5e76\u68c0\u6d4b\u4e86\u7eb3\u7c73\u805a\u96c6\u4f53\u5728\u4f53\u5185\u7684\u539f\u4f4d\u5149\u70ed\u81f4\u53cc\u6001\u8f6c\u5316\u8fc7\u7a0b\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u57fa\u4e8e\u6b64\uff0c\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u7684\u738b\u6d69\u7814\u7a76\u5458\u3001\u4e54\u589e\u83b9\u7279\u8058\u7814\u7a76\u5458\u56e2\u961f\u548c\u5929\u6d25\u5927\u5b66\u7684\u9648\u5fd7\u575a\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8054\u5408\u62a5\u9053\u4e86\u4e00\u7c7b\u57fa\u4e8e\u4e24\u4eb2\u6027BF2<\/sub>-\u6c2e\u6742\u6c1f\u787c\u4e8c\u5421\u54af\uff08aza-BODIPY\uff09\u7684\u7eb3\u7c73\u805a\u96c6\u4f53\uff0c\u8be5\u805a\u96c6\u4f53\u53ef\u901a\u8fc7\u8fd1\u7ea2\u5916\uff08NIR\uff09\u6fc0\u5149\u8c03\u63a7\u5f62\u6001\u7684\u8f6c\u5316\uff0c\u4ece\u800c\u5728\u4f53\u5185\u540c\u65f6\u5b9e\u73b0\u4e86\u957f\u65f6\u95f4\u8840\u6db2\u5faa\u73af\u548c\u80bf\u7624\u7684\u6df1\u5c42\u6e17\u900f\u3002\u9996\u5148\uff0c\u5f53\u6e29\u5ea6\u5347\u9ad8\u65f6\uff0c\u5177\u6709\u8f83\u957f\u8840\u6db2\u5faa\u73af\u65f6\u95f4\u7684aza-BODIPY-1\u5206\u5b50\u7684\u8815\u866b\u72b6\u7eb3\u7c73\u7ea4\u7ef4\u72b6\uff081-NFs\uff09\u805a\u96c6\u4f53\u53ef\u4ee5\u8f6c\u53d8\u4e3a\u7403\u5f62\u7eb3\u7c73\u9897\u7c92\uff081-NPs\uff09\uff0c\u6709\u5229\u4e8e\u589e\u52a0\u5728\u5b9e\u4f53\u7624\u4e2d\u7684\u6e17\u900f\u3002\u5176\u6b21\uff0c\u7eb3\u7c73\u7ea4\u7ef4J-\u805a\u96c6\u4f53\u5728NIR\u5149\u8c31\u8303\u56f4\u5185\u5177\u6709\u975e\u5e38\u7a84\u7684\u5438\u6536\u5e26\uff0c\u56e0\u6b64\u5b83\u4eec\u5177\u6709\u7406\u60f3\u7684\u5149\u70ed\u6027\u80fd\u3002\u901a\u8fc7655 nm\u6fc0\u5149\u7167\u5c04\uff0c\u5149\u70ed\u6548\u5e94\u53ef\u5bfc\u81f4\u5c40\u90e8\u6e29\u5ea6\u5347\u9ad8\u5230\u7ea648 o<\/sup>C\uff0c\u4ece\u800c\u5b9e\u73b01-NFs\u54111-NPs\u7684\u76f8\u53d8\u3002\u7b2c\u4e09\uff0c\u901a\u8fc7\u5149\u58f0\uff08PA\uff09\u6210\u50cf\u53ef\u4ee5\u5b9e\u65f6\u76d1\u6d4b\u805a\u96c6\u7684\u5f62\u6001\u8f6c\u53d8\u3002\u901a\u8fc7\u76d1\u6d4b\u7279\u5b9a\u6ce2\u957f\u4e0bPA\u4fe1\u53f7\u7684\u53d8\u5316\uff0c\u53ef\u4ee5\u8ffd\u8e2a\u7eb3\u7c73\u6750\u6599\u7684\u4f53\u5185\u76f8\u53d8\u8fc7\u7a0b\u3002\u7814\u7a76\u8868\u660e\uff0c\u57fa\u4e8e\u4e24\u4eb2\u6027aza-BODIPY\u5206\u5b50\u7684\u7eb3\u7c73\u805a\u96c6\u4f53\u901a\u8fc7\u539f\u4f4d\u5f62\u6001\u8f6c\u53d8\u540c\u65f6\u5b9e\u73b0\u4e86\u4f53\u5185\u957f\u8840\u6db2\u5faa\u73af\u548c\u80bf\u7624\u6df1\u5c42\u6e17\u900f\uff0c\u4ece\u800c\u589e\u5f3a\u4e86\u6297\u80bf\u7624\u6548\u679c\u3002\u8be5\u7814\u7a76\u6210\u679c\u4ee5\u201cNear-Infrared Laser-Triggered In Situ Dimorphic Transformation of BF2<\/sub>-Azadipyrromethene Nanoaggregates for Enhanced Solid Tumor Penetration\u201d<\/strong>\u4e3a\u9898\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aACS Nano<\/strong>\u4e0a\u3002
\n \"\"<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u6e29\u5ea6\u89e6\u53d1\u7684aza-BODIPY\u7eb3\u7c73\u805a\u96c6\u4f53\u5f62\u6001\u8f6c\u53d8<\/strong>
\n \"\"\uff08a\uff09aza-BODIPY\u603b\u6d53\u5ea6\u4e3a150 \u03bcM \u76841-NFs\u5728PBS\u4e2d\u52a0\u70ed\u81f3\u4e0d\u540c\u6e29\u5ea6\u4e0b\uff0837\u300146\u300148\u548c50\u00a0o<\/sup>C\uff09\u7684UV\/Vis\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

\uff08b\uff09\u5728799 nm\u5904\u76d1\u6d4b\u7684J-\u805a\u96c6\u6001\uff081-NFs\uff09\u6469\u5c14\u5206\u6570\u968f\u6e29\u5ea6\u53d8\u5316\uff1b<\/p>\n

\uff08c\uff09\u5ba4\u6e29\u4e0b\uff0caza-BODIPY\u6d53\u5ea6\u4e3a50 \u03bcM \u76841-NFs\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08d\uff09\u901a\u8fc7\u5c061-NFs\uff08aza-BODIPY\u6d53\u5ea6\u4e3a50 \u03bcM\uff09\u52a0\u70ed\u523050 o<\/sup>C\u83b7\u5f97\u7684\u83b7\u5f97\u76841-NPs\u7684TEM\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e8c\u3001PA\u6210\u50cf\u76d1\u6d4b\u7eb3\u7c73\u805a\u96c6\u4f53\u7684\u5f62\u6001\u8f6c\u53d8\u8fc7\u7a0b<\/strong>
\n \"\"\uff08a\uff09aza-BODIPY\u6d53\u5ea6\u4e3a150 \u03bcM \u7684PBS\u6eb6\u6db2\u4e2d\uff0c\u5728680-850 nm\u8303\u56f4\u51851-NFs\u548c1-NPs\u7684PA\u4fe1\u53f7\u66f2\u7ebf\u56fe\uff1b<\/p>\n

\uff08b\uff09100 \u03bcM\u76841-NFs\u5728800 nm\u548c745 nm\u5904\u6e29\u5ea6\u4f9d\u8d56\u7684PA\u4fe1\u53f7\uff1b<\/p>\n

\uff08c\uff09\u572840\u300144\u300146\u300148\u548c50 o<\/sup>C\u7684\u6761\u4ef6\u4e0b\uff0c1-NFs\u5728800 nm\u548c745 nm\u6fc0\u53d1\u6ce2\u957f\u4e0b\u7684PA\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e09\u3001NIR\u6fc0\u5149\u5f15\u53d1\u7eb3\u7c73\u805a\u96c6\u4f53\u7684\u5f62\u6001\u8f6c\u53d8<\/strong>
\n \"\"\uff08a\uff09\u5728\u4e0d\u540c\u529f\u7387\u5bc6\u5ea6\u4e0b\uff0c655 nm\u6fc0\u5149\u8f90\u7167\u4e0b3 min\uff0c\u4e0d\u540c\u6d53\u5ea61-NFs\u7684PBS\u6eb6\u6db2\u4e2d\u7684\u5347\u6e29\u67f1\u72b6\u56fe\uff1b<\/p>\n

\uff08b\uff091-NFs\uff08aza-BODIPY\u6d53\u5ea6\u4e3a50 \u03bcM\uff09\u7684AFM\u56fe\u50cf\uff08\u5e95\u90e8\uff1a\u6cbf\u865a\u7ebf\u7684\u6a2a\u622a\u9762\u5206\u6790\uff09\uff1b<\/p>\n

\uff08c\uff09\u5728\u529f\u7387\u5bc6\u5ea6\u4e3a1.0 W\u00b7cm-2<\/sup>\u7684NIR\u7167\u5c043 min\u540e\uff0c1-NFs\u7684AFM\u56fe\uff08\u5e95\u90e8\uff1a\u6cbf\u865a\u7ebf\u7684\u6a2a\u622a\u9762\u5206\u6790\uff09\u3002<\/p>\n

\u56fe\u56db\u3001\u5728MCS\u6c34\u5e73\u7684\u7eb3\u7c73\u805a\u96c6\u4f53\u7684\u6e17\u900f\u80fd\u529b\u7814\u7a76<\/strong>
\n \"\"\uff08a\uff09\u8fd1\u7ea2\u5916\u6fc0\u5149\u5f15\u53d1\u76841-NFs\u54111-NPs\u8f6c\u53d8\u53caMCS\u6df1\u5ea6\u6e17\u900f\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09CLSM\u663e\u5fae\u955c\u89c2\u5bdf\uff0c\u6d53\u5ea6\u4e3a25 \u03bcM\u7684\u8d1f\u8f7d\u5c3c\u7f57\u7ea2\u76841-NFs\u548c1-NPs\u5b75\u80b22 h\u7684MCF-7 MCS\u3002<\/p>\n

\u56fe\u4e94\u3001\u8bc4\u4f30\u7eb3\u7c73\u805a\u96c6\u4f53\u5728MCS\u6c34\u5e73\u7684\u6297\u80bf\u7624\u6d3b\u6027<\/strong>
\n \"\"\uff08a\uff09\u7528aza-BODIPY\u6d53\u5ea6\u4e3a25 \u03bcM\u76841-NFs+\u6fc0\u5149\u30011-NPs+\u6fc0\u5149\u30012-NFs+\u6fc0\u5149\uff08\u53c2\u7167\u7269\uff0c\u8be6\u89c1\u8bba\u6587\uff09\u548cPBS\u5904\u7406\u7684MCF-7 MCS\u7684\u4ee3\u8868\u56fe\u50cf\uff1b<\/p>\n

\uff08b\uff09\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684MCS\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

\uff08c\uff09\u7528aza-BODIPY\u6d53\u5ea6\u4e3a25 \u03bcM\u76841-NFs+\u6fc0\u5149\u30011-NPs+\u6fc0\u5149\u30012-NFs+\u6fc0\u5149\u548cPBS\u5904\u7406\u7684MCF-7\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u3002<\/p>\n

\u56fe\u516d\u3001\u7eb3\u7c73\u805a\u96c6\u4f53\u7684\u80bf\u7624\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b<\/strong>
\n \"\"\uff08a\uff09McF-7\u8377\u7624\u5c0f\u9f20\u5c3e\u9759\u8109\u6ce8\u5c041-NFs\u548c1-NPs\u540e\uff0c\u4e0d\u540c\u65f6\u95f4\u91c7\u96c6\u7684\u8840\u6db2\u7684\u5f52\u4e00\u5316\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

\uff08b\uff09\u4ece\u5c0f\u9f20\u8eab\u4e0a\u89e3\u5256\u51fa\u6765\u7684\u80bf\u7624\u5728\u6d78\u6ca1\u57281-NFs\u4e2d2\u5c0f\u65f6\u540e\u7684\u79bb\u4f53PA\u6210\u50cf\uff1b<\/p>\n

\uff08c\uff09\u4ece\u80bf\u7624\u8fb9\u7f18\u5230\u4e2d\u5fc3\u7684\u5e73\u5747PA\u4fe1\u53f7\u5f3a\u5ea6\u7684\u91cf\u5316\uff1b<\/p>\n

\uff08d\uff09\u5728655 nm\u7684NIR\u7167\u5c043 min\u540e\uff0c\u957f\u8fbe2 h\u7684\u80bf\u7624\u6a2a\u65ad\u9762\u76841-NFs\u548c2-NFs\u7684PA\u56fe\u50cf\uff1b<\/p>\n

\uff08e\uff09\u7167\u5c04\u540e\u957f\u8fbe2 h\u7684\u80bf\u7624\u90e8\u4f4dPA\u4fe1\u53f7\u5f3a\u5ea6\u7684\u539f\u4f4d\u5b9a\u91cf\u3002<\/p>\n

\u56fe\u4e03\u3001\u7eb3\u7c73\u805a\u96c6\u4f53\u7684\u4f53\u5185\u6297\u80bf\u7624\u6d3b\u6027<\/strong>
\n \"\"\uff08a\uff09\u7528PBS\u3001PBS+\u6fc0\u5149\u30012-NFs+\u6fc0\u5149\u30011-NFs+\u6fc0\u5149\u548c1-NPs+\u6fc0\u5149\u5904\u7406\u540e\uff0c\u5bf9MCF-7\u8377\u7624\u88f8\u9f20\u7684\u80bf\u7624\u751f\u957f\u6291\u5236\u4f5c\u7528\uff1b<\/p>\n

\uff08b\uff09\u572821 d\u7684\u6cbb\u7597\u671f\u95f4\uff0c\u5c0f\u9f20\u7684\u4f53\u91cd\u53d8\u5316\uff1b<\/p>\n

\uff08c\uff09\u6cbb\u759721 d\u540e\uff0c\u8377\u7624\u5c0f\u9f20\u7684\u5fc3\u810f\u3001\u809d\u810f\u3001\u813e\u810f\u3001\u80ba\u548c\u80be\u810f\u5207\u7247\u7684\u4ee3\u8868\u6027\u663e\u5fae\u7167\u7247\uff08H\uff06E\u67d3\u8272\uff09\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u5229\u7528\u7ea4\u7ef4\u7684aza-BODIPY\u805a\u96c6\u4f53\uff081-NFs\uff09\u53ca\u5176\u539f\u4f4dNIR\u89e6\u53d1\u76841-NFs\u5411\u7403\u5f62\u7eb3\u7c73\u9897\u7c921-NPs\u7684\u8f6c\u5316\uff0c\u540c\u65f6\u5b9e\u73b0\u4e86\u957f\u8840\u6db2\u5faa\u73af\u548c\u80bf\u7624\u7a7f\u900f\u80fd\u529b\u589e\u5f3a\u30021-NFs\u5728\u4f53\u5185\u7684\u8840\u6db2\u5faa\u73af\u65f6\u95f4\u8f83\u957f\uff0c\u662f\u7403\u5f621-NPs\u76847.6\u500d\u3002\u5728\u80bf\u7624\u90e8\u4f4d\u79ef\u7d2f\u540e\uff0c1-NFs\u5728NIR\u6fc0\u5149\u7167\u5c04\u4e0b\u8f6c\u5316\u4e3a1-NPs\u3002\u7531\u4e8e\u5176\u56fa\u6709\u7684\u5149\u70ed\u7279\u6027\uff0c\u751f\u6210\u76841-NPs\u6df1\u5165\u5b9e\u4f53\u80bf\u7624\u540e\uff0c\u901a\u8fc7\u5149\u70ed\u6548\u5e94\u53ef\u4ee5\u6709\u6548\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u901a\u8fc7PA\u6210\u50cf\u5b9e\u65f6\u76d1\u6d4bPA\u4fe1\u53f7\u5728\u7279\u5b9a\u6ce2\u957f\u7684\u53d8\u5316\uff0c\u6210\u529f\u76d1\u6d4b\u4e861-NFs\u52301-NPs\u7684\u4f53\u5185\u5f62\u6001\u8f6c\u5316\u8fc7\u7a0b\u3002\u56e0\u6b64\uff0c\u4ee5\u53cc\u805a\u96c6\u4e3a\u7279\u5f81\u7684aza-BODIPY-1\u805a\u96c6\u4f53\u5728NIR\u6fc0\u5149\u8f90\u5c04\u4e0b\u7684\u539f\u4f4d\u5f62\u6001\u8f6c\u5316\uff0c\u4e3a\u957f\u6548\u8840\u5faa\u73af\u548c\u80bf\u7624\u6df1\u5c42\u6e17\u900f\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u6cbb\u7597\u5e94\u7528\u524d\u666f\u7684\u7b56\u7565\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aNear-Infrared Laser-Triggered In Situ Dimorphic Transformation of BF2<\/sub>-Azadipyrromethene Nanoaggregates for Enhanced Solid Tumor Penetration<\/a><\/strong>\uff08ACS Nano<\/em>, 2020<\/strong>, DOI: 10.1021\/acsnano.0c00118\uff09<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

\u738b\u6d69, \u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u5fb7\u56fd\u6d2a\u5821\u5b66\u8005\uff0c\u4e2d\u79d1\u9662\u767e\u4eba\u8ba1\u5212\u7814\u7a76\u5458\uff0c\u56fd\u5bb6\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u83b7\u5f97\u8005\u3002<\/strong>2000\u5e74\u6bd5\u4e1a\u4e8e\u5357\u5f00\u5927\u5b66\u5316\u5b66\u7cfb\uff0c\u5e76\u88ab\u4fdd\u9001\u5357\u5f00\u5927\u5b66\u5316\u5b66\u7cfb\u76f4\u63a5\u653b\u8bfb\u535a\u58eb\u5b66\u4f4d\uff0c\u4ece\u4e8b\u8d85\u5206\u5b50\u81ea\u7ec4\u88c5\u4f53\u7cfb\u7684\u6784\u7b51\u53ca\u5176\u529f\u80fd\u7684\u7814\u7a76\uff0c2005\u5e74\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\u3002\u540c\u5e74\u83b7\u5f97\u5fb7\u56fd\u6d2a\u5821\u5956\u5b66\u91d1\uff0c\u5728\u5fb7\u56fd\u7ef4\u5c14\u8328\u5821\u5927\u5b66\uff08University of Wurzburg\uff09\u8fdb\u884c\u53ef\u63a7\u7ec4\u88c5\u5149\u5b66\u6d3b\u6027\u5206\u5b50\u7814\u7a76\u30022007\u5e74\u5728\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff08UCLA\uff09\u533b\u5b66\u9662\u548c\u52a0\u5dde\u7eb3\u7c73\u7cfb\u7edf\u7814\u7a76\u9662\uff08CNSI\uff09\u8fdb\u884c\u535a\u58eb\u540e\u7814\u7a76\uff0c\u4e3b\u8981\u4ece\u4e8b\u7eb3\u7c73\u6750\u6599\u7684\u5236\u5907\u4e0e\u8868\u5f81\u53ca\u5176\u5728\u764c\u75c7\u8bca\u65ad\u4e0e\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u30022011\u5e74\u53d7\u8058\u4e8e\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\uff0c\u4e2d\u79d1\u9662\u7eb3\u7c73\u751f\u7269\u6548\u5e94\u4e0e\u5b89\u5168\u6027\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u3002\u4e3b\u8981\u4ece\u4e8b\u4f53\u5185\u81ea\u7ec4\u88c5\u9ad8\u5206\u5b50\u751f\u7269\u533b\u7528\u6750\u6599\u3001\u7eb3\u7c73\u751f\u7269\u6750\u6599\u3001\u836f\u7269\u8f7d\u4f53\u53ca\u5176\u5728\u75be\u75c5\u8bca\u7597\u4e2d\u7684\u5e94\u7528\u7814\u7a76\u3002\u53d1\u8868Nature Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater.\u7b49\u8bba\u6587100\u4f59\u7bc7\uff0c\u51fa\u7248\u4e13\u8457\u201cIn vivo self-assembly nanotechnology for biomedical applications\u201d(Springer publisher)’ \uff0c\u53c2\u7f165\u90e8\u4e13\u8457\u7ae0\u8282\uff0c\u7533\u8bf7\u7f8e\u56fd\u4e13\u52293\u9879\uff0c\u56fd\u5185\u4e13\u522915\u9879\u3002\u76ee\u524d\u4f5c\u4e3a\u9879\u76ee\u548c\u8bfe\u9898\u8d1f\u8d23\u4eba\u627f\u62c5\u4e86\u56fd\u5bb6\u91cd\u70b9\u57fa\u7840\u7814\u7a76\u53d1\u5c55\u8ba1\u5212\uff08973\uff09\uff0c\u4e2d\u79d1\u9662\u6d77\u5916\u5f15\u8fdb\u6770\u51fa\u4eba\u624d\u8ba1\u5212\uff0c \u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u9879\u76ee\u548c\u5317\u4eac\u5e02\u79d1\u59d4\u9879\u76ee\u7b49\u3002<\/p>\n

\u4e54\u589e\u83b9\u7b80\u4ecb\uff1a\u7406\u5b66\u535a\u58eb\uff0c\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\uff0c\u7279\u8058\u7814\u7a76\u5458\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u9752\u4fc3\u4f1a\u4f1a\u5458\uff0c\u5317\u4eac\u5e02\u79d1\u6280\u65b0\u661f\u3002<\/strong>2007\u5e74\u6bd5\u4e1a\u4e8e\u5c71\u4e1c\u5927\u5b66\u5316\u5b66\u4e13\u4e1a\uff0c\u83b7\u5f97\u5b66\u58eb\u5b66\u4f4d\u30022012\u5e74\u5728\u5317\u4eac\u5927\u5b66\u9ad8\u5206\u5b50\u5316\u5b66\u4e0e\u7269\u7406\u4e13\u4e1a\u83b7\u5f97\u7406\u5b66\u535a\u58eb\u5b66\u4f4d\u30022012\u81f3\u4eca\u5728\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u4efb\u52a9\u7406\u7814\u7a76\u5458\u3001\u526f\u7814\u7a76\u5458\u53ca\u7279\u8058\u7814\u7a76\u5458\u30022018\u5e74-2019\u5e74\u5728\u7f8e\u56fd\u5e03\u5170\u8fea\u65af\u5927\u5b66\u8fdb\u884c\u8bbf\u5b66\u3002\u76ee\u524d\u4e3b\u8981\u4ece\u4e8b\u65b0\u578b\u591a\u80bd\u805a\u5408\u7269\u53ca\u5176\u4f53\u5185\u81ea\u7ec4\u88c5\u65b9\u9762\u7684\u7814\u7a76\u3002\u5171\u53d1\u8868SCI\u8bba\u658750\u4f59\u7bc7\uff0c\u5176\u4e2d\u4ee5\u7b2c\u4e00\/\u901a\u8baf\u4f5c\u8005\u8eab\u4efd\u5728Adv. Mater., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nano Lett.\u7b49\u671f\u520a\u4e0a\u53d1\u8868\u6587\u7ae020\u4f59\u7bc7\u3002<\/p>\n

\u9648\u5fd7\u575a\u7b80\u4ecb\uff1a\u5929\u6d25\u5927\u5b66\u5316\u5de5\u5b66\u9662\u6559\u6388\uff0c\u535a\u58eb\u751f\u5bfc\u5e08<\/strong>\uff0c 1996\u5e74\u5b66\u58eb\u6bd5\u4e1a\u4e8e\u5317\u4eac\u5927\u5b66\u5316\u5b66\u7cfb\uff0c1999\u5e74\u7855\u58eb\u6bd5\u4e1a\u4e8e\u4e2d\u56fd\u79d1\u5b66\u9662\u611f\u5149\u5316\u5b66\u7814\u7a76\u6240\uff0c 2006\u5e74\u535a\u58eb\u6bd5\u4e1a\u4e8e\u5fb7\u56fd\u7ef4\u5c14\u8328\u5821\u5927\u5b66(Universit\u00e4t W\u00fcrzburg)\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\uff0c 2006-2008\u5e74\u4e8e\u7f8e\u56fd\u7f57\u5207\u65af\u7279\u5927\u5b66(University of Rochester)\u5316\u5b66\u5de5\u7a0b\u7cfb\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\u5de5\u4f5c\uff0c2009\u5e74\u4efb\u6559\u4e8e\u5929\u6d25\u5927\u5b66\u5316\u5de5\u5b66\u9662\uff0c\u76ee\u524d\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u5305\u62ec\u6709\u673a\u529f\u80fd\u5206\u5b50\u7684\u5408\u6210\u4e0e\u81ea\u7ec4\u88c5\u3001\u5206\u5b50\u805a\u96c6\u4f53\u3001\u7eb3\u7c73\u6750\u6599\u3001\u8d85\u5206\u5b50\u805a\u5408\u7269\u7b49\u3002<\/p>\n

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